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href=\"https:\/\/www.hjtdsm.cn\/ar\/stem-cells\/stem-cell-therapy\/19059.html\/#%E7%BB%93%E8%AF%AD%EF%BC%9A%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E8%84%8A%E9%AB%93%E6%8D%9F%E4%BC%A4%E4%B8%AD%E7%9A%84%E5%8E%9F%E7%90%86%E3%80%81%E9%80%82%E7%94%A8%E4%BA%BA%E7%BE%A4%E5%8F%8A%E6%B2%BB%E7%96%97%E6%B5%81%E7%A8%8B\" >\u7ed3\u8bed\uff1a\u5e72\u7ec6\u80de\u6cbb\u7597\u810a\u9ad3\u635f\u4f24\u4e2d\u7684\u539f\u7406\u3001\u9002\u7528\u4eba\u7fa4\u53ca\u6cbb\u7597\u6d41\u7a0b<\/a><\/li><\/ul><\/li><\/ul><\/nav><\/div>\n<h1><span class=\"ez-toc-section\" id=\"%E7%98%AB%E7%97%AA%E6%9C%89%E6%9C%9B%E6%81%A2%E5%A4%8D%EF%BC%9F%E8%AF%A6%E8%A7%A3%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E8%84%8A%E9%AB%93%E6%8D%9F%E4%BC%A4%E7%9A%84%E5%8E%9F%E7%90%86%E3%80%81%E9%80%82%E7%94%A8%E4%BA%BA%E7%BE%A4%E5%8F%8A%E6%B2%BB%E7%96%97%E6%B5%81%E7%A8%8B\"><\/span>\u0647\u0644 \u0645\u0646 \u0627\u0644\u0645\u062a\u0648\u0642\u0639 \u0623\u0646 \u064a\u062a\u0639\u0627\u0641\u0649 \u0627\u0644\u0634\u0644\u0644\u061f \u0634\u0631\u062d \u062a\u0641\u0635\u064a\u0644\u064a \u0644\u0645\u0628\u062f\u0623 \u0627\u0644\u0639\u0644\u0627\u062c \u0628\u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062c\u0630\u0639\u064a\u0629 \u0644\u0625\u0635\u0627\u0628\u0627\u062a \u0627\u0644\u062d\u0628\u0644 \u0627\u0644\u0634\u0648\u0643\u064a \u0648\u0625\u0645\u0643\u0627\u0646\u064a\u0629 \u062a\u0637\u0628\u064a\u0642\u0647 \u0648\u0639\u0645\u0644\u064a\u0629 \u0627\u0644\u0639\u0644\u0627\u062c<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<h2><span class=\"ez-toc-section\" id=\"%E4%B8%80%E3%80%81%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E8%84%8A%E9%AB%93%E6%8D%9F%E4%BC%A4%E7%9A%84%E5%8E%9F%E7%90%86%EF%BC%9A%E5%B9%B2%E7%BB%86%E8%83%9E%E5%A6%82%E4%BD%95%E5%AF%B9%E6%8A%97%E8%84%8A%E9%AB%93%E6%8D%9F%E4%BC%A4\"><\/span>\u4e00\u3001\u5e72\u7ec6\u80de\u6cbb\u7597\u810a\u9ad3\u635f\u4f24\u7684\u539f\u7406\uff1a\u5e72\u7ec6\u80de\u5982\u4f55\u5bf9\u6297\u810a\u9ad3\u635f\u4f24<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>\u5e72\u7ec6\u80de\u4e4b\u6240\u4ee5\u88ab\u5bc4\u4e88\u539a\u671b\uff0c\u662f\u56e0\u4e3a\u5b83\u4eec\u62e5\u6709\u201c\u5206\u5316\u201d\u548c\u201c\u4fee\u590d\u73af\u5883\u8c03\u8282\u201d\u7684\u80fd\u529b\u3002\u5176\u4e3b\u8981\u673a\u5236\u53ef\u6982\u62ec\u4e3a\u4ee5\u4e0b\u4e94\u5927\u65b9\u9762\uff1a<sup>[1]<\/sup><\/p>\n<p><strong>1. \u514d\u75ab\u8c03\u8282\u4e0e\u6297\u708e<\/strong>\uff1a\u810a\u9ad3\u635f\u4f24\u540e\uff0c\u5c40\u90e8\u4f1a\u51fa\u73b0\u5f3a\u70c8\u708e\u75c7\uff0c\u5927\u91cf\u708e\u6027\u56e0\u5b50\uff08\u5982TNF-\u03b1\u3001IL-1\u03b2\uff09\u4f1a\u7834\u574f\u5065\u5eb7\u795e\u7ecf\u3002\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09\u53ef\u5206\u6ccc\u6297\u708e\u56e0\u5b50\uff08\u5982IL-10\u3001TGF-\u03b2\uff09\uff0c\u6291\u5236\u8fc7\u5ea6\u708e\u75c7\uff0c\u5c06\u7834\u574f\u6027\u7684M1\u578b\u5c0f\u80f6\u8d28\u7ec6\u80de\u8f6c\u4e3a\u4fdd\u62a4\u6027\u7684M2\u578b\uff0c\u50cf\u201c\u706d\u706b\u201d\u4e00\u6837\uff0c\u4e3a\u4fee\u590d\u521b\u9020\u7a33\u5b9a\u73af\u5883\u3002<\/p>\n<p><strong>2. \u795e\u7ecf\u8425\u517b\u4e0e\u4fdd\u62a4<\/strong>\uff1a\u5e72\u7ec6\u80de\u80fd\u5206\u6ccc\u591a\u79cd\u795e\u7ecf\u8425\u517b\u56e0\u5b50\uff08\u5982BDNF\u3001NGF\u3001GDNF\uff09\uff0c\u4e3a\u6fd2\u6b7b\u795e\u7ecf\u5143\u63d0\u4f9b\u201c\u517b\u6599\u201d\uff0c\u589e\u5f3a\u5b58\u6d3b\u80fd\u529b\uff0c\u540c\u65f6\u523a\u6fc0\u53d7\u635f\u795e\u7ecf\u7ea4\u7ef4\u751f\u957f\u65b0\u4fa7\u679d\uff0c\u5c1d\u8bd5\u7ed5\u8fc7\u635f\u4f24\u533a\u57df\uff0c\u91cd\u65b0\u5efa\u7acb\u8fde\u63a5\u3002<\/p>\n<p><strong>3. \u4fc3\u8fdb\u8840\u7ba1\u518d\u751f<\/strong>\uff1a\u635f\u4f24\u4f1a\u7834\u574f\u5c40\u90e8\u8840\u7ba1\uff0c\u5bfc\u81f4\u795e\u7ecf\u7f3a\u6c27\u7f3a\u517b\u3002\u5e72\u7ec6\u80de\u53ef\u5206\u6cccVEGF\u7b49\u56e0\u5b50\uff0c\u4fc3\u8fdb\u65b0\u8840\u7ba1\u751f\u6210\uff0c\u4e3a\u53d7\u635f\u533a\u57df\u8f93\u9001\u6c27\u6c14\u548c\u8425\u517b\uff0c\u4e3a\u957f\u671f\u4fee\u590d\u6253\u4e0b\u57fa\u7840\u3002<\/p>\n<p><strong>4. \u8c03\u8282\u80f6\u8d28\u7622\u75d5<\/strong>\uff1a\u635f\u4f24\u540e\u5f62\u6210\u7684\u80f6\u8d28\u7622\u75d5\u5728\u65e9\u671f\u53ef\u4fdd\u62a4\u7ec4\u7ec7\uff0c\u4f46\u540e\u671f\u4f1a\u963b\u788d\u8f74\u7a81\u518d\u751f\u3002\u5e72\u7ec6\u80de\u80fd\u8c03\u8282\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\uff0c\u51cf\u5c11\u7622\u75d5\u7684\u963b\u788d\u4f5c\u7528\uff0c\u5e76\u5206\u6ccc\u9176\u7c7b\u964d\u89e3\u6291\u5236\u6027\u5206\u5b50\uff0c\u4e3a\u8f74\u7a81\u751f\u957f\u201c\u6e05\u7406\u8def\u969c\u201d\u3002<\/p>\n<p><strong>5. \u7ec6\u80de\u66ff\u4ee3\u4e0e\u6865\u63a5<\/strong>\uff1a\u90e8\u5206\u5e72\u7ec6\u80de\uff08\u5982\u795e\u7ecf\u5e72\u7ec6\u80de\u3001\u5c11\u7a81\u80f6\u8d28\u524d\u4f53\u7ec6\u80de\uff09\u53ef\u5206\u5316\u4e3a\u65b0\u7684\u795e\u7ecf\u5143\u6216\u80f6\u8d28\u7ec6\u80de\u3002\u5c11\u7a81\u80f6\u8d28\u7ec6\u80de\u5f62\u6210\u65b0\u7684\u9ad3\u9798\uff0c\u6062\u590d\u795e\u7ecf\u4fe1\u53f7\u4f20\u5bfc\uff1b\u65b0\u751f\u7ec6\u80de\u8fd8\u80fd\u5728\u635f\u4f24\u533a\u57df\u4e24\u7aef\u642d\u5efa\u201c\u751f\u7269\u6865\u201d\uff0c\u5f15\u5bfc\u8f74\u7a81\u91cd\u65b0\u8fde\u63a5\u3002<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%E4%BA%8C%E3%80%81%E5%B9%B2%E7%BB%86%E8%83%9E%E6%9D%A5%E6%BA%90%EF%BC%9A%E5%A4%9A%E7%A7%8D%E7%B1%BB%E5%9E%8B%E7%9A%84%E6%B2%BB%E7%96%97%E9%80%89%E6%8B%A9\"><\/span>\u4e8c\u3001\u5e72\u7ec6\u80de\u6765\u6e90\uff1a\u591a\u79cd\u7c7b\u578b\u7684\u6cbb\u7597\u9009\u62e9<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>\u5728\u810a\u9ad3\u635f\u4f24\u7684\u5e72\u7ec6\u80de\u7814\u7a76\u4e2d\uff0c\u79d1\u5b66\u5bb6\u4eec\u63a2\u7d22\u4e86\u591a\u79cd\u5e72\u7ec6\u80de\u6765\u6e90\uff1a<a href=\"https:\/\/journals.sagepub.com\/doi\/10.1177\/0963689721989266\" rel=\"nofollow noopener\" target=\"_blank\"><sup>[2]<\/sup><\/a><\/p>\n<p><strong>\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09<\/strong>\uff1a\u5e38\u89c1\u4e8e\u8110\u5e26\u3001\u80ce\u76d8\u3001\u8102\u80aa\u7ec4\u7ec7\u4e2d\u3002\u5b83\u4eec\u4e3b\u8981\u4e0d\u662f\u76f4\u63a5\u53d8\u6210\u795e\u7ecf\u7ec6\u80de\uff0c\u800c\u662f\u901a\u8fc7\u5206\u6ccc\u591a\u79cd\u8425\u517b\u56e0\u5b50\u548c\u8c03\u8282\u514d\u75ab\u53cd\u5e94\uff0c\u6765\u6539\u5584\u635f\u4f24\u90e8\u4f4d\u7684\u5fae\u73af\u5883\uff0c\u6291\u5236\u708e\u75c7\uff0c\u4fdd\u62a4\u6b8b\u5b58\u7684\u795e\u7ecf\u5143\uff0c\u5e76\u4fc3\u8fdb\u5185\u6e90\u6027\u4fee\u590d\u3002<\/p>\n<p><strong>\u795e\u7ecf\u5e72\u7ec6\u80de\uff08NSCs\uff09<\/strong>\uff1aNSCs\u5177\u6709\u5411\u795e\u7ecf\u5143\u3001\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u548c\u5c11\u7a81\u80f6\u8d28\u7ec6\u80de\u5206\u5316\u7684\u6f5c\u529b\uff0c\u53ef\u76f4\u63a5\u66ff\u4ee3\u635f\u4f24\u90e8\u4f4d\u7684\u7ec6\u80de\u3002\u5b83\u4eec\u8fd8\u80fd\u5206\u6ccc\u795e\u7ecf\u8425\u517b\u56e0\u5b50\u3001\u8c03\u8282\u5c40\u90e8\u708e\u75c7\uff0c\u5e76\u5728\u635f\u4f24\u533a\u57df\u5f62\u6210\u201c\u751f\u7269\u6865\u201d\uff0c\u4e3a\u8f74\u7a81\u751f\u957f\u63d0\u4f9b\u5bfc\u5411\u3002<\/p>\n<p><strong>\u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de\uff08iPSCs\uff09<\/strong>\uff1aiPSCs\u6765\u6e90\u4e8e\u6210\u4eba\u4f53\u7ec6\u80de\uff08\u5982\u76ae\u80a4\u6216\u8840\u6db2\uff09\uff0c\u901a\u8fc7\u91cd\u7f16\u7a0b\u83b7\u5f97\u591a\u80fd\u6027\u3002\u5b83\u4eec\u53ef\u5206\u5316\u4e3a\u795e\u7ecf\u5143\u6216\u80f6\u8d28\u7ec6\u80de\uff0c\u7406\u8bba\u4e0a\u80fd\u66ff\u4ee3\u53d7\u635f\u7ec6\u80de\uff0c\u5e76\u5728\u4f53\u5916\u901a\u8fc7\u57fa\u56e0\u7f16\u8f91\u6216\u9884\u5206\u5316\u6280\u672f\u589e\u5f3a\u5b89\u5168\u6027\u548c\u529f\u80fd\u6027\u3002iPSCs\u7684\u4f18\u52bf\u5728\u4e8e\u53ef\u5927\u91cf\u5236\u5907\uff0c\u4e14\u53ef\u5b9e\u73b0\u4e2a\u4f53\u5316\u6cbb\u7597\uff0c\u4f46\u6280\u672f\u590d\u6742\u3001\u6210\u672c\u9ad8\uff0c\u4e14\u6f5c\u5728\u80bf\u7624\u98ce\u9669\u4ecd\u9700\u76d1\u63a7\u3002<\/p>\n<p><strong>\u80da\u80ce\u5e72\u7ec6\u80de (ESC)\uff1a<\/strong>ESCs\u53d6\u81ea\u65e9\u671f\u80da\u80ce\uff0c\u5177\u6709\u9ad8\u5ea6\u591a\u80fd\u6027\uff0c\u53ef\u5206\u5316\u4e3a\u4efb\u4f55\u7c7b\u578b\u7684\u795e\u7ecf\u548c\u80f6\u8d28\u7ec6\u80de\u3002\u5b83\u4eec\u5728\u52a8\u7269\u5b9e\u9a8c\u4e2d\u663e\u793a\u51fa\u8f83\u5f3a\u7684\u518d\u751f\u6f5c\u529b\uff0c\u4f46\u4f26\u7406\u4e89\u8bae\u3001\u514d\u75ab\u6392\u65a5\u53ca\u80bf\u7624\u98ce\u9669\u662f\u4e34\u5e8a\u5e94\u7528\u7684\u91cd\u8981\u9650\u5236\u56e0\u7d20\u3002<\/p>\n<p><strong>\u7ec6\u80de\u5916\u56ca\u6ce1 (EV)\u00a0\uff1a<\/strong>EVs\u662f\u7531\u5e72\u7ec6\u80de\u5206\u6ccc\u7684\u5fae\u5c0f\u56ca\u6ce1\uff0c\u5185\u542b\u86cb\u767d\u8d28\u3001RNA\u7b49\u4fe1\u53f7\u5206\u5b50\u3002\u5b83\u4eec\u53ef\u4ee5\u4f20\u9012\u795e\u7ecf\u8425\u517b\u548c\u514d\u75ab\u8c03\u8282\u4fe1\u53f7\uff0c\u6539\u5584\u635f\u4f24\u5fae\u73af\u5883\uff0c\u800c\u4e0d\u9700\u8981\u79fb\u690d\u6d3b\u7ec6\u80de\uff0c\u4ece\u800c\u964d\u4f4e\u79fb\u690d\u76f8\u5173\u98ce\u9669\u3002EVs\u6b63\u5728\u6210\u4e3a\u201c\u65e0\u7ec6\u80de\u7597\u6cd5\u201d\u7684\u7814\u7a76\u70ed\u70b9\uff0c\u5c24\u5176\u9002\u5408\u5e0c\u671b\u51cf\u5c11\u514d\u75ab\u6216\u80bf\u7624\u98ce\u9669\u7684\u60a3\u8005\u3002<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%E4%B8%89%E3%80%81%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E8%84%8A%E9%AB%93%E6%8D%9F%E4%BC%A4%E7%9A%84%E9%80%82%E7%94%A8%E4%BA%BA%E7%BE%A4%EF%BC%9A%E5%93%AA%E4%BA%9B%E6%82%A3%E8%80%85%E9%80%82%E5%90%88%E5%B0%9D%E8%AF%95\"><\/span>\u4e09\u3001\u5e72\u7ec6\u80de\u6cbb\u7597\u810a\u9ad3\u635f\u4f24\u7684\u9002\u7528\u4eba\u7fa4\uff1a\u54ea\u4e9b\u60a3\u8005\u9002\u5408\u5c1d\u8bd5<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>\u5e72\u7ec6\u80de\u6cbb\u7597\u5e76\u975e\u5bf9\u6240\u6709\u810a\u9ad3\u635f\u4f24\u60a3\u8005\u90fd\u9002\u7528\u3002\u4e00\u822c\u4e34\u5e8a\u548c\u7814\u7a76\u7ecf\u9a8c\u63d0\u793a\uff1a<\/p>\n<p>\u6309\u635f\u4f24\u65f6\u671f\u5206\uff1a<\/p>\n<ul class=\"wp-block-list\">\n<li><strong>\u4e9a\u6025\u6027\u671f\uff08\u635f\u4f24\u540e2\u5468\u20136\u4e2a\u6708\uff09<\/strong>\uff1a\u901a\u5e38\u88ab\u8ba4\u4e3a\u662f\u201c\u7a97\u53e3\u671f\u201d\uff0c\u5c40\u90e8\u708e\u75c7\u9010\u6b65\u53d7\u63a7\uff0c\u5185\u6e90\u6027\u4fee\u590d\u5c1a\u6709\u4f59\u5730\uff0c\u90e8\u5206\u7814\u7a76\u663e\u793a\u8be5\u671f\u53d7\u76ca\u53ef\u80fd\u8f83\u5927\u3002<\/li>\n<li><strong>\u6162\u6027\u671f\uff08&gt;6\u4e2a\u6708\uff09<\/strong>\uff1a\u7622\u75d5\u5f62\u6210\u548c\u7ec4\u7ec7\u7ed3\u6784\u91cd\u5851\u8f83\u660e\u663e\uff0c\u7406\u8bba\u4e0a\u66f4\u96be\u5b9e\u73b0\u663e\u8457\u7ed3\u6784\u6027\u4fee\u590d\uff0c\u4f46\u4ecd\u6709\u7814\u7a76\u62a5\u9053\u529f\u80fd\u6539\u5584\u3002<\/li>\n<\/ul>\n<p>\u6309\u635f\u4f24\u7a0b\u5ea6\u5206\uff1a<\/p>\n<ul class=\"wp-block-list\">\n<li><strong>\u4e0d\u5b8c\u5168\u6027\u635f\u4f24\uff08\u5982ASIA 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id=\"%E5%9B%9B%E3%80%81%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E8%84%8A%E9%AB%93%E6%8D%9F%E4%BC%A4%E7%9C%9F%E5%AE%9E%E4%B8%B4%E5%BA%8A%E6%A1%88%E4%BE%8B\"><\/span>\u56db\u3001\u5e72\u7ec6\u80de\u6cbb\u7597\u810a\u9ad3\u635f\u4f24\u771f\u5b9e\u4e34\u5e8a\u6848\u4f8b<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>2025\u5e742\u670811\u65e5\uff0c\u65e5\u672c\u518d\u751f\u533b\u5b66\u7814\u7a76\u4e2d\u5fc3\u5728\u56fd\u9645\u6743\u5a01\u671f\u520a\u300aNature Medicine\u300b\u4e0a\u53d1\u8868\u9898\u4e3a\u300a\u4eba\u7c7b\u810a\u9ad3\u635f\u4f24\u7684\u5e72\u7ec6\u80de\u7597\u6cd5\uff1a\u8fd1\u671f\u4e34\u5e8a\u7814\u7a76\u8fdb\u5c55\u4e0e\u8f6c\u5316\u8def\u5f84\u5206\u6790\u300b\u7684\u7cfb\u7edf\u6027\u7efc\u8ff0\u3002<sup>[3]<\/sup><\/p>\n<p>\u8be5\u7814\u7a76\u5168\u9762\u68b3\u7406\u4e86<strong>\u4ece2024\u5e745\u6708\u523012\u6708\u5185\u5168\u740317\u9879\u5e72\u7ec6\u80de\u6cbb\u7597\u810a\u9ad3\u635f\u4f24\uff08SCI\uff09\u7684\u4e34\u5e8a\u8bd5\u9a8c\u6570\u636e<\/strong>\uff0c\u9996\u6b21\u63d0\u51fa\u201c\u7ec6\u80de\u79fb\u690d\u8054\u5408\u5eb7\u590d\u5e72\u9884\u201d\u53ef\u663e\u8457\u63d0\u5347\u795e\u7ecf\u529f\u80fd\u6062\u590d\u7387\uff0c\u5e76\u5f3a\u8c03\u5e72\u7ec6\u80de\u7597\u6cd5\u5df2\u5b9e\u73b0\u4e9a\u6025\u6027SCI\u60a3\u8005<strong>\u8fd0\u52a8\u529f\u80fd\u6539\u5584\u8fbe40%\u7684\u7a81\u7834\u6027\u7597\u6548<\/strong>\u3002<\/p>\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/09\/20250924194720-68d3da486aa33.png\" alt=\"\" title=\"\"><\/figure>\n<p>\u7814\u7a76\u5f3a\u8c03\uff0c\u810a\u9ad3\u635f\u4f24\uff08SCI\uff09\u4e34\u5e8a\u7814\u7a76\u5728\u8fc7\u53bb\u5341\u5e74\u53d6\u5f97\u663e\u8457\u8fdb\u5c55\uff0c\u7814\u7a76\u5bf9\u8c61\u6db5\u76d6\u80ce\u513f\u6e90\u6027NS\/PC\u53ca\u591a\u80fd\u5e72\u7ec6\u80de\uff08ES\/iPSC\uff09\u884d\u751fNS\/PC\u3001\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSC\uff09\u3001\u55c5\u9798\u7ec6\u80de\u4e0e\u65bd\u4e07\u7ec6\u80de\u7b49\u3002<strong>\u4e9a\u6025\u6027SCI\u60a3\u8005\u7684\u4e34\u5e8a\u6570\u636e\u5df2\u663e\u793a\u8fd0\u52a8\u529f\u80fd\u6539\u5584\u7684\u79ef\u6781\u4fe1\u53f7<\/strong>\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u540c\u79cd\u5f02\u4f53NS\/PC\u76f8\u8f83\u81ea\u4f53MSC\u5177\u6709\u66f4\u5f3a\u7684\u810a\u9ad3\u6574\u5408\u80fd\u529b\u4e14\u53ef\u6807\u51c6\u5316\u751f\u4ea7\uff0c\u9002\u7528\u4e8e\u8d85\u6025\u6027\u671f\u5e72\u9884\u3002\u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de\uff08iPSC\uff09\u7684\u57fa\u56e0\u7f16\u8f91\u6280\u672f\u7a81\u7834\u4f7f\u5176\u6210\u4e3a\u672a\u6765\u7cbe\u51c6\u6cbb\u7597\u7684\u5173\u952e\u65b9\u5411\uff0c\u6709\u671b\u901a\u8fc7\u5b9a\u5236\u5316\u7ec6\u80de\u65b9\u6848\u89e3\u51b3\u4f9b\u4f53\u5339\u914d\u4e0e\u514d\u75ab\u6392\u65a5\u95ee\u9898\u3002<\/p>\n<p>\u76f8\u5173\u9605\u8bfb\uff1a2025\u5e741-8\u6708\u5e72\u7ec6\u80de\u6cbb\u7597\u810a\u9ad3\u635f\u4f24\u6700\u65b0\u8fdb\u5c55\uff1a\u5173\u952e\u4e34\u5e8a\u6570\u636e\u76d8\u70b9<\/p>\n<h2><span 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class=\"ez-toc-section\" id=\"%E7%BB%93%E8%AF%AD%EF%BC%9A%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E8%84%8A%E9%AB%93%E6%8D%9F%E4%BC%A4%E4%B8%AD%E7%9A%84%E5%8E%9F%E7%90%86%E3%80%81%E9%80%82%E7%94%A8%E4%BA%BA%E7%BE%A4%E5%8F%8A%E6%B2%BB%E7%96%97%E6%B5%81%E7%A8%8B\"><\/span>\u7ed3\u8bed\uff1a\u5e72\u7ec6\u80de\u6cbb\u7597\u810a\u9ad3\u635f\u4f24\u4e2d\u7684\u539f\u7406\u3001\u9002\u7528\u4eba\u7fa4\u53ca\u6cbb\u7597\u6d41\u7a0b<span 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dir=\"auto\" style=\"vertical-align: inherit;\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\">[1]Shinozaki, M.\uff1bNagoshi, N.\uff1bNakamura, M. \uff1b<\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"> Okano, H. \u5e72\u7ec6\u80de\u6cbb\u7597\u810a\u9ad3\u635f\u4f24\u7684\u673a\u5236\u3002Cells\u00a0 <\/span><\/span><em><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">2021<\/span><\/span><\/em>\u00a0<span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> ,\u00a0 <\/span><em><span dir=\"auto\" style=\"vertical-align: inherit;\">10<\/span><\/em><span dir=\"auto\" style=\"vertical-align: inherit;\"> , 2676. https:\/\/doi.org\/10.3390\/cells10102676<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">[2]Huang L, Fu C, Xiong F, He C, Wei Q. \u810a\u9ad3\u635f\u4f24\u7684\u5e72\u7ec6\u80de\u6cbb\u7597\u3002\u00a0 <\/span><\/span><em><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u300a\u7ec6\u80de\u79fb\u690d\u300b<\/span><\/span><\/em><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u30022021;30\u3002doi:10.1177\/0963689721989266<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">[3]Sugai K, Nakamura M, Okano H, Nagoshi N. \u4eba\u7c7b\u810a\u9ad3\u635f\u4f24\u7684\u5e72\u7ec6\u80de\u7597\u6cd5\uff1a\u8fd1\u671f\u4e34\u5e8a\u7814\u7a76\u7efc\u8ff0\u3002\u300a\u8111\u810a\u67f1\u300b\u30022025\u5e742\u67087\u65e5;5:104207\u3002doi: 10.1016\/j.bas.2025.104207\u3002PMID: 40027291\uff1bPMCID: 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