{"id":19131,"date":"2025-09-25T04:00:57","date_gmt":"2025-09-24T12:00:57","guid":{"rendered":"https:\/\/www.hjtdsm.cn\/stem-cells\/stem-cell-therapy\/19131.html"},"modified":"2025-10-11T17:01:07","modified_gmt":"2025-10-11T09:01:07","slug":"https-www-hjtdsm-cn-stem-cells-stem-cell-therapy-19131-html","status":"publish","type":"post","link":"https:\/\/www.hjtdsm.cn\/ar\/stem-cells\/stem-cell-therapy\/19131.html","title":{"rendered":"\u0627\u0644\u0645\u0631\u0627\u062c\u0639\u0629 \u0627\u0644\u062d\u062f\u064a\u062b\u0629: \u0645\u0642\u0627\u0631\u0646\u0629 \u0627\u0644\u0641\u0639\u0627\u0644\u064a\u0629 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0644\u0644\u0639\u0644\u0627\u062c \u0628\u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062c\u0630\u0639\u064a\u0629 \u0641\u064a \u0639\u0644\u0627\u062c \u0627\u0644\u0635\u062f\u0645\u0627\u062a \u0627\u0644\u0639\u0635\u0628\u064a\u0629 \u0648\u0627\u0644\u0623\u0645\u0631\u0627\u0636 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ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-18\" href=\"https:\/\/www.hjtdsm.cn\/ar\/stem-cells\/stem-cell-therapy\/19131.html\/#%E8%AE%A8%E8%AE%BA%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E7%A5%9E%E7%BB%8F%E5%88%9B%E4%BC%A4%E5%92%8C%E7%A5%9E%E7%BB%8F%E9%80%80%E8%A1%8C%E6%80%A7%E7%96%BE%E7%97%85%E7%9A%84%E4%B8%B4%E5%BA%8A%E7%96%97%E6%95%88\" >\u8ba8\u8bba\u5e72\u7ec6\u80de\u6cbb\u7597\u795e\u7ecf\u521b\u4f24\u548c\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u7684\u4e34\u5e8a\u7597\u6548<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-19\" href=\"https:\/\/www.hjtdsm.cn\/ar\/stem-cells\/stem-cell-therapy\/19131.html\/#%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E7%A5%9E%E7%BB%8F%E9%80%80%E8%A1%8C%E6%80%A7%E7%96%BE%E7%97%85%E7%9A%84%E7%96%97%E6%95%88%E6%9C%BA%E5%88%B6%E4%B8%8E%E7%BB%BC%E5%90%88%E6%BD%9C%E5%8A%9B\" 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>\u672a\u6765\u6211\u4eec\u5e94\u8be5\u600e\u4e48\u505a\uff1f<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-23\" href=\"https:\/\/www.hjtdsm.cn\/ar\/stem-cells\/stem-cell-therapy\/19131.html\/#%E7%BB%93%E8%AE%BA\" >\u7ed3\u8bba<\/a><\/li><\/ul><\/li><\/ul><\/nav><\/div>\n<h1 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E6%9C%80%E6%96%B0%E7%BB%BC%E8%BF%B0%EF%BC%9A%E6%AF%94%E8%BE%83%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E7%A5%9E%E7%BB%8F%E5%88%9B%E4%BC%A4%E5%92%8C%E7%A5%9E%E7%BB%8F%E9%80%80%E8%A1%8C%E6%80%A7%E7%96%BE%E7%97%85%E7%9A%84%E4%B8%B4%E5%BA%8A%E7%96%97%E6%95%88%E6%8A%A5%E9%81%93\"><\/span>\u6700\u65b0\u7efc\u8ff0\uff1a\u6bd4\u8f83<span class=\"xintheme_tag_link\">\u0627\u0644\u0639\u0644\u0627\u062c \u0628\u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062c\u0630\u0639\u064a\u0629<\/span>\u795e\u7ecf\u521b\u4f24\u548c\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u7684\u4e34\u5e8a\u7597\u6548\u62a5\u9053<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<p>\u8fd1\u65e5\uff0c\u77e5\u540d\u671f\u520a\u6742\u5fd7\u300a<a href=\"https:\/\/link.springer.com\/article\/10.1007\/s13770-025-00757-2\" target=\"_blank\" rel=\"nofollow noopener\">Tissue Engineering and Regenerative Medicine<\/a>\u300b\u53d1\u8868\u4e86\u4e00\u7bc7\u6709\u5173\u201c\u5e72\u7ec6\u80de\u6cbb\u7597\u795e\u7ecf\u521b\u4f24\u548c\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u7684\u4e34\u5e8a\u7597\u6548\uff1a\u6bd4\u8f83\u7efc\u8ff0\u201d\u7684\u6587\u732e\u7efc\u8ff0[1]\u3002<\/p>\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/09\/20250924200054-68d3dd7681a01.png\" alt=\"\" title=\"\"><figcaption><\/figcaption><\/figure>\n<p>\u8be5\u7efc\u8ff0\u63a2\u8ba8\u4e86PubMed\u6570\u636e\u5e93\u4e2d\u5173\u4e8e\u7ec6\u80de\u7597\u6cd5\u6cbb\u7597\u795e\u7ecf\u521b\u4f24\u548c\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u7684\u73b0\u6709\u6587\u732e\uff0c\u65e8\u5728\u9610\u660e\u54ea\u4e9b\u7ec6\u80de\u7c7b\u578b\u5bf9\u810a\u9ad3\u635f\u4f24\u3001\u521b\u4f24\u6027\u8111\u635f\u4f24\u548c\u808c\u840e\u7f29\u4fa7\u7d22\u786c\u5316\u75c7\u7684\u6cbb\u7597\u6709\u6548\u3002<\/p>\n<p>\u6700\u7ec8\u7ed3\u5408\u8fd1\u5341\u5e74\u7684\u7814\u7a76\u8868\u660e\uff0c\u9aa8\u9ad3\u5e72\u7ec6\u80de\u548c\u795e\u7ecf\u5e72\u7ec6\u80de\u53ef\u6709\u6548\u6cbb\u7597\u795e\u7ecf\u521b\u4f24\u6027\u75be\u75c5\uff0c\u800c<span class=\"xintheme_tag_link\">\u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062c\u0630\u0639\u064a\u0629 \u0627\u0644\u0648\u0633\u064a\u0637\u0629 \u0627\u0644\u0648\u0633\u064a\u0637\u0629 MSC (\u0641\u064a \u0628\u064a\u0648\u0644\u0648\u062c\u064a\u0627 \u0627\u0644\u062e\u0644\u064a\u0629)<\/span>\u548c\u795e\u7ecf\u5e72\u7ec6\u80de\u53ef\u6709\u6548\u6cbb\u7597\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\uff08\u4f8b\u5982\u808c\u840e\u7f29\u4fa7\u7d22\u786c\u5316\u75c7\uff09\u3002<\/p>\n<p><strong>\u65b9\u6cd5\uff1a<\/strong>\u6211\u4eec\u4ecePubMed\u6570\u636e\u5e93\u4e2d\u68c0\u7d22\u4e862014\u5e74\u81f32024\u5e74\u53d1\u8868\u7684\u7814\u7a76\uff0c\u68c0\u7d22\u8bcd\u5305\u62ec\u4f46\u4e0d\u9650\u4e8e\u201c\u810a\u9ad3\u635f\u4f24\u201d\u3001\u201c\u8111\u635f\u4f24\u201d\u3001\u201c\u808c\u840e\u7f29\u4fa7\u7d22\u786c\u5316\u75c7\u201d\u3001\u201c\u518d\u751f\u533b\u5b66\u201d\u3001\u201c\u7ec6\u80de\u7597\u6cd5\u201d\u548c\u201c\u5e72\u7ec6\u80de\u201d\u3002\u6839\u636ePRISMA 2020\u58f0\u660e\uff0c\u5bf9\u7814\u7a76\u8fdb\u884c\u4e86\u7b5b\u9009\u3001\u7eb3\u5165\u548c\u6392\u9664\u3002\u6700\u7ec8\u786e\u5b9a\u5e76\u9009\u5b9a\u4e8633\u9879\u7814\u7a76\u7528\u4e8e\u672c\u7efc\u8ff0\uff08\u56fe1\uff09\u3002<\/p>\n<figure class=\"wp-block-image size-full\">\n<p><div style=\"width: 695px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/09\/20250924200054-68d3dd76a1c0b.png\" alt=\"\u56fe1:\u7814\u7a76\u6d41\u7a0b\" width=\"685\" height=\"546\" title=\"\"><p class=\"wp-caption-text\">\u56fe1:\u7814\u7a76\u6d41\u7a0b<\/p><\/div><figcaption><\/figcaption><\/figure>\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E7%A5%9E%E7%BB%8F%E5%88%9B%E4%BC%A4%E5%92%8C%E7%A5%9E%E7%BB%8F%E9%80%80%E8%A1%8C%E6%80%A7%E7%96%BE%E7%97%85%E7%9A%84%E4%B8%B4%E5%BA%8A%E7%96%97%E6%95%88%E7%9A%84%E7%BB%93%E6%9E%9C\"><\/span><strong>\u5e72\u7ec6\u80de\u6cbb\u7597\u795e\u7ecf\u521b\u4f24\u548c\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u7684\u4e34\u5e8a\u7597\u6548\u7684\u7ed3\u679c<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E8%84%8A%E9%AB%93%E6%8D%9F%E4%BC%A4\"><\/span><strong><span class=\"xintheme_tag_link\">\u5e72\u7ec6\u80de\u6cbb\u7597\u810a\u9ad3\u635f\u4f24<\/span><\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u76ee\u524d\u5229\u7528\u7ec6\u80de\u7597\u6cd5\u6cbb\u7597\u96be\u6cbb\u6027\u810a\u9ad3\u635f\u4f24\u7684\u7814\u7a76\u5df2\u6709\u6570\u5341\u7bc7\uff08\u88681\uff09\uff0c\u5728\u9888\u690e\u3001\u80f8\u690e\u3001\u8170\u690e\u810a\u9ad3\u635f\u4f24\u7684\u75c5\u4f8b\u4e2d\uff0c\u5e94\u7528<strong>\u81ea\u4f53\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08\u9aa8\u9ad3\u6765\u6e90\u7ec6\u80de\u3001\u8102\u80aa\u6765\u6e90\u7ec6\u80de\uff09\u3001\u540c\u79cd\u5f02\u4f53\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u3001\u795e\u7ecf\u5e72\u7ec6\u80de\u3001\u534e\u901a\u80f6\u6765\u6e90\u7ec6\u80de\u3001\u5c11\u7a81\u80f6\u8d28\u7ec6\u80de\u7956\u7ec6\u80de<\/strong>\u7b49\u3002<\/p>\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/09\/20250924200054-68d3dd76b303e.png\" alt=\"\" title=\"\"><figcaption><\/figcaption><\/figure>\n<figure class=\"wp-block-image size-full\">\n<p><div style=\"width: 1259px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/09\/20250924200055-68d3dd770daaa.png\" alt=\"\u88681\uff1a\u5e72\u7ec6\u80de\u7c7b\u578b\u53ca\u5176\u5728\u810a\u9ad3\u635f\u4f24\u6cbb\u7597\u4e2d\u7684\u4e0d\u540c\u7597\u6548\" width=\"1249\" height=\"914\" title=\"\"><p class=\"wp-caption-text\">\u88681\uff1a\u5e72\u7ec6\u80de\u7c7b\u578b\u53ca\u5176\u5728\u810a\u9ad3\u635f\u4f24\u6cbb\u7597\u4e2d\u7684\u4e0d\u540c\u7597\u6548<\/p><\/div><figcaption><\/figcaption><\/figure>\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E8%87%AA%E4%BD%93%E9%97%B4%E5%85%85%E8%B4%A8%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E8%84%8A%E9%AB%93%E6%8D%9F%E4%BC%A4\"><\/span><strong>\u81ea\u4f53\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6cbb\u7597\u810a\u9ad3\u635f\u4f24<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u81ea\u4f53\u9aa8\u9ad3\u6765\u6e90\u7ec6\u80de\u5728\u80f8\u8170\u6bb5\u810a\u9ad3\u635f\u4f24\uff08SCI\uff09\u60a3\u8005\u4e2d\u7684\u6cbb\u7597\u6f5c\u529b\u5df2\u5f97\u5230\u521d\u6b65\u8bc1\u5b9e\u3002<\/p>\n<p><strong>\u65e9\u671f\u75c5\u4f8b\u4e0e\u5c0f\u89c4\u6a21\u7814\u7a76\u7684\u7ed3\u679c\uff1a<\/strong>\u6700\u65e9\u57282015\u5e74\uff0cJarocha\u7b49\u4eba\u901a\u8fc7\u81ea\u4f53\u9aa8\u9ad3\u6709\u6838\u7ec6\u80de\uff08BMNCs\uff09\u6cbb\u7597\u80f8\u6bb5SCI\u60a3\u8005\uff0c<strong>\u7ed3\u679c\u663e\u793aAIS\u5206\u7ea7\u4eceA\u63d0\u5347\u81f3C\/D\uff0c\u5e76\u4f34\u968f\u611f\u89c9\u6c34\u5e73\u53ca\u8180\u80f1\u3001\u809b\u95e8\u529f\u80fd\u7684\u6062\u590d<\/strong>\u3002\u968f\u540eBansal\u7b49\u4eba\u572810\u4f8b\u8170\u6bb5SCI\u60a3\u8005\u4e2d\u5e94\u7528\u81ea\u4f53\u9aa8\u9ad3\u5e72\u7ec6\u80de\uff0c\u5176\u4e2d\u591a\u6570\u60a3\u8005\u5728\u8fd0\u52a8\u3001\u6392\u5c3f\u53ca\u6027\u529f\u80fd\u65b9\u9762\u5747\u6709\u4e0d\u540c\u7a0b\u5ea6\u6539\u5584\uff0c\u4e14\u672a\u51fa\u73b0\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\u3002<\/p>\n<p><strong>\u4e2d\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e0e\u8102\u80aa\u6765\u6e90MSC\u7684\u5e94\u7528\uff1a<\/strong>2024\u5e74Awidi\u7b49\u4eba\u5f00\u5c55\u7684\u968f\u673a\u4e34\u5e8a\u8bd5\u9a8c\u8fdb\u4e00\u6b65\u9a8c\u8bc1\u4e86\u9aa8\u9ad3\u6765\u6e90MSC\u7684\u7597\u6548\uff0c\u7ed3\u679c\u663e\u793a\u9888\u6bb5\u548c\u80f8\u6bb5SCI\u60a3\u8005\u666e\u904d\u51fa\u73b0AIS\u5206\u7ea7\u63d0\u5347\uff0c\u4e14\u5b89\u5168\u6027\u826f\u597d\u3002\u4e0e\u6b64\u540c\u65f6\uff0cHur\u7b49\u4eba\u4f7f\u7528\u81ea\u4f53\u8102\u80aa\u6765\u6e90MSC\u6cbb\u7597\u4e0d\u540c\u6c34\u5e73\u7684SCI\uff0c<strong>\u968f\u8bbf8\u4e2a\u6708\u65f6\u7ea6\u4e09\u5206\u4e4b\u4e00\u60a3\u8005AIS\u5206\u7ea7\u6539\u5584\uff0c\u90e8\u5206\u60a3\u8005\u809b\u95e8\u6536\u7f29\u53ca\u611f\u89c9\u529f\u80fd\u4e5f\u5f97\u5230\u6062\u590d\uff0c\u4f46\u62a5\u544a\u4e86\u8f7b\u5ea6\u4e0d\u826f\u53cd\u5e94<\/strong>\u3002<\/p>\n<p><strong>\u6700\u65b0\u7814\u7a76\u4e0e\u603b\u4f53\u7ed3\u8bba\uff1a<\/strong>Honmou\u7b49\u4eba\u9488\u5bf9\u9888\u6bb5SCI\u60a3\u8005\u7684\u7814\u7a76\u663e\u793a\uff0c\u7edd\u5927\u591a\u6570\u60a3\u8005\u57286\u4e2a\u6708\u5185AIS\u5206\u7ea7\u6539\u5584\uff0c\u751a\u81f3\u6709\u90e8\u5206\u60a3\u8005\u63d0\u53472\u4e2a\u5206\u7ea7\u3002\u7efc\u5408\u4e0d\u540c\u7814\u7a76\u7ed3\u679c\uff0c<strong>\u81ea\u4f53\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08\u5305\u62ec\u9aa8\u9ad3\u4e0e\u8102\u80aa\u6765\u6e90\uff09\u5728\u9798\u5185\u3001\u9759\u8109\u53ca\u810a\u9ad3\u5185\u591a\u79cd\u7ed9\u836f\u9014\u5f84\u4e0b\u5747\u5c55\u73b0\u51fa\u4e00\u5b9a\u7597\u6548\uff0c\u5c24\u5176\u662f\u5728\u8fd0\u52a8\u3001\u611f\u89c9\u53ca\u90e8\u5206\u81ea\u4e3b\u529f\u80fd\u6062\u590d\u65b9\u9762<\/strong>\uff0c\u4e3aSCI\u60a3\u8005\u63d0\u4f9b\u4e86\u65b0\u7684\u6cbb\u7597\u5e0c\u671b\u3002<\/p>\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E5%BC%82%E4%BD%93%E9%97%B4%E5%85%85%E8%B4%A8%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E8%84%8A%E9%AB%93%E6%8D%9F%E4%BC%A4\"><\/span><strong>\u5f02\u4f53\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6cbb\u7597\u810a\u9ad3\u635f\u4f24<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u5f02\u4f53\u6c83\u987f\u80f6\u6765\u6e90MSCs\uff08WJ-MSCs\uff09\u4e3a\u7ec6\u80de\u6765\u6e90\u63d0\u4f9b\u4e86\u65b0\u601d\u8def\u3002\u75c5\u4f8b\u62a5\u544a\u663e\u793a\uff0c<strong>\u901a\u8fc7\u8170\u690e\u7a7f\u523a\u6216\u9798\u5185\u6ce8\u5c04\u5f02\u4f53WJ-MSCs\uff0c\u80f8\u6bb5SCI\u60a3\u8005\u5728\u611f\u89c9\u3001\u8180\u80f1\u3001\u809b\u95e8\u529f\u80fd\u53ca\u4e0b\u80a2\u808c\u529b\u65b9\u9762\u5747\u83b7\u5f97\u663e\u8457\u6539\u5584\uff0c\u4e14\u7597\u6548\u5728\u957f\u8fbe18-25\u4e2a\u6708\u7684\u968f\u8bbf\u4e2d\u4fdd\u6301\u7a33\u5b9a\uff0c\u672a\u51fa\u73b0\u4e25\u91cd\u5e76\u53d1\u75c7<\/strong>\uff0c\u63d0\u793a\u4e86\u5176\u4f5c\u4e3a\u201c\u73b0\u8d27\u578b\u201d\u5f02\u4f53\u5e72\u7ec6\u80de\u4ea7\u54c1\u7684\u5b89\u5168\u6027\u4e0e\u4ef7\u503c\u3002<\/p>\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E7%A5%9E%E7%BB%8F%E5%B9%B2%E7%BB%86%E8%83%9E%EF%BC%88NSCs%EF%BC%89%E6%B2%BB%E7%96%97%E8%84%8A%E9%AB%93%E6%8D%9F%E4%BC%A4\"><\/span><strong>\u795e\u7ecf\u5e72\u7ec6\u80de\uff08NSCs\uff09\u6cbb\u7597\u810a\u9ad3\u635f\u4f24<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u795e\u7ecf\u5e72\u7ec6\u80de\uff08NSCs\uff09\u5728\u6cbb\u7597\u9888\u690e\u3001\u80f8\u690e\u548c\u8170\u690e\u5404\u4e3b\u8981\u6c34\u5e73\u7684\u6162\u6027\u810a\u9ad3\u635f\u4f24\uff08SCI\uff09\u4e2d\u5747\u663e\u793a\u51fa\u4e00\u5b9a\u7597\u6548\uff0c\u8fd1\u5341\u5e74\u5df2\u6709\u56db\u9879\u4e34\u5e8a\u8bd5\u9a8c\u8bc1\u5b9e\u8fd9\u4e00\u70b9\u3002<\/p>\n<p><strong>\u9888\u9ad3\u635f\u4f24\u6cbb\u7597\u6848\u4f8b\uff1a<\/strong>Shin\u56e2\u961f\u9488\u5bf919\u4f8b\u6162\u6027\u9888\u9ad3\u635f\u4f24\u60a3\u8005\uff08\u591a\u4e3a\u5b8c\u5168\u6027\u635f\u4f24\uff09\uff0c\u91c7\u7528\u80ce\u8111\u6765\u6e90\u795e\u7ecf\u5e72\/\u7956\u7ec6\u80de\uff08hNSPCs\uff09\u8fdb\u884c\u9ad3\u5185\u6ce8\u5c04\u3002<strong>\u6cbb\u7597\u540e26.3%\u7684\u60a3\u8005\u51fa\u73b0AIS\u5206\u7ea7\u663e\u8457\u6539\u5584\uff08\u5982\u4eceA\u7ea7\u5347\u81f3C\u7ea7\uff09\uff0c\u4e14\u4e00\u5e74\u968f\u8bbf\u672a\u53d1\u73b0\u80bf\u7624\u5f62\u6210\u3001\u795e\u7ecf\u529f\u80fd\u6076\u5316\u6216\u75bc\u75db\u52a0\u91cd\u7b49\u4e25\u91cd\u4e0d\u826f\u53cd\u5e94<\/strong>\uff0c\u8bc1\u660e\u4e86\u9888\u6bb5\u6cbb\u7597\u7684\u5b89\u5168\u6027\u53ca\u529f\u80fd\u6062\u590d\u6f5c\u529b\u3002<\/p>\n<p><strong>\u80f8\u9ad3\u635f\u4f24\u6cbb\u7597\u6848\u4f8b\uff1a<\/strong>2018\u5e74\uff0cCurtis\u7b49\u4eba\u5bf94\u4f8b\u80f8\u6bb5\u810a\u9ad3\u635f\u4f24\u60a3\u8005\uff08T2-T8\u8282\u6bb5\uff09\u6ce8\u5c04\u810a\u9ad3\u6765\u6e90\u7684NSI-566\u7ec6\u80de\u3002\u5c3d\u7ba1\u56fd\u9645\u795e\u7ecf\u529f\u80fd\u6807\u51c6\u8bc4\u5206\uff08ISNCSCI\uff09\u672a\u5168\u90e8\u6539\u5584\uff0c\u4f46\u808c\u7535\u56fe\u68c0\u6d4b\u5230T7\u60a3\u8005\u8179\u76f4\u808c\u4e0e\u80f8\u690e\u65c1\u808c\u51fa\u73b0\u65b0\u81ea\u4e3b\u6d3b\u52a8\uff0c<strong>T5\u548cT8\u60a3\u8005\u51fa\u73b0\u611f\u89c9\u8fd0\u52a8\u8282\u6bb5\u6027\u6062\u590d\uff0c\u4e14\u65e0\u6ce8\u5c04\u76f8\u5173\u5e76\u53d1\u75c7\uff0c\u8868\u660e\u80f8\u6bb5\u6cbb\u7597\u53ef\u4fc3\u8fdb\u795e\u7ecf\u518d\u652f\u914d<\/strong>\u3002<\/p>\n<p><strong>\u9888\u9ad3\u635f\u4f24\u591a\u7ef4\u5ea6\u8bc4\u4f30\u6848\u4f8b\uff1a<\/strong>Levi\u56e2\u961f\u901a\u8fc7\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\uff0c\u5bf96\u4f8b\u56db\u80a2\u762b\u60a3\u8005\u79fb\u690d\u80ce\u8111\u6765\u6e90HuCNS-SC\u7ec6\u80de\u3002<strong>\u91c7\u7528\u7279\u5f02\u6027\u4e0a\u80a2\u529f\u80fd\u8bc4\u5206\uff08UEMS\/GRASSP\uff09\u53d1\u73b0\u60a3\u8005\u6293\u63e1\u529b\u548c\u8fd0\u52a8\u529f\u80fd\u663e\u8457\u63d0\u5347\uff08\u5982UEMS\u8bc4\u5206\u4ece1.25\u5347\u81f32.83\uff09<\/strong>\uff0c\u4f46\u7814\u7a76\u4e5f\u62a5\u544a\u4e86\u5207\u53e3\u611f\u67d3\u4e0e\u8840\u80bf\u7b49\u624b\u672f\u76f8\u5173\u98ce\u9669\uff0c\u63d0\u793a\u9700\u5e73\u8861\u7597\u6548\u4e0e\u4fb5\u5165\u6027\u64cd\u4f5c\u5e26\u6765\u7684\u6f5c\u5728\u5e76\u53d1\u75c7\u3002<\/p>\n<p>\u5c3d\u7ba1\u591a\u9879\u7814\u7a76\u7ed3\u679c\u4ee4\u4eba\u9f13\u821e\uff0c\u8868\u660eNSCs\u5728\u4e0d\u540c\u6c34\u5e73SCI\u7684\u6cbb\u7597\u4e2d\u5177\u6709\u6f5c\u5728\u4ef7\u503c\uff0c\u4f46\u7406\u60f3\u7684\u5242\u91cf\u4e0e\u7ed9\u836f\u65b9\u5f0f\u4ecd\u672a\u7edf\u4e00\u3002\u6b64\u5916\uff0c\u867d\u7136\u591a\u6570\u7814\u7a76\u91c7\u7528AIS\u5206\u7ea7\u4f5c\u4e3a\u7597\u6548\u8bc4\u4f30\u6307\u6807\uff0c\u4f46\u90e8\u5206\u7814\u7a76\u4f7f\u7528ISNCSCI\u3001UEMS\u6216GRASSP\u7b49\u5176\u4ed6\u91cf\u8868\uff0c\u5bfc\u81f4\u4e0d\u540c\u7814\u7a76\u4e4b\u95f4\u7684\u7597\u6548\u96be\u4ee5\u76f4\u63a5\u6bd4\u8f83\u3002<\/p>\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E5%B0%91%E7%AA%81%E8%83%B6%E8%B4%A8%E7%BB%86%E8%83%9E%E5%89%8D%E4%BD%93%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E8%84%8A%E9%AB%93%E6%8D%9F%E4%BC%A4\"><\/span><strong>\u5c11\u7a81\u80f6\u8d28\u7ec6\u80de\u524d\u4f53\u7ec6\u80de\u6cbb\u7597\u810a\u9ad3\u635f\u4f24<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u7531\u4eba\u80da\u80ce\u5e72\u7ec6\u80de\u884d\u751f\u7684OPCs\uff08\u5982LCTOPC1\uff09\u4e3a\u6cbb\u7597\u63d0\u4f9b\u4e86\u65b0\u65b9\u5411\u3002\u4e00\u9879\u5f00\u653e\u6807\u7b7e\u3001\u5242\u91cf\u9012\u589e\u7684\u4e34\u5e8a\u8bd5\u9a8c\u663e\u793a\uff0c\u5728\u63a5\u53d7\u9798\u5185\u6ce8\u5c04\u768425\u4f8b\u9888\u9ad3\u635f\u4f24\u60a3\u8005\u4e2d\uff0c\u7edd\u5927\u591a\u6570\uff0821\/22\uff09\u5728\u8eab\u4f53\u81f3\u5c11\u4e00\u4fa7\u6062\u590d\u4e86\u4e00\u4e2a\u6216\u66f4\u591a\u6c34\u5e73\u7684\u795e\u7ecf\u529f\u80fd\uff0c\u5c55\u73b0\u4e86\u5176\u4fc3\u8fdb\u795e\u7ecf\u4fee\u590d\u7684\u6f5c\u529b\uff0c\u4f46\u9700\u5173\u6ce8\u8111\u810a\u6db2\u6f0f\u548c\u611f\u67d3\u7b49\u624b\u672f\u76f8\u5173\u98ce\u9669\u3002<\/p>\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E5%88%9B%E4%BC%A4%E6%80%A7%E8%84%91%E6%8D%9F%E4%BC%A4\"><\/span><strong>\u5e72\u7ec6\u80de\u6cbb\u7597\u521b\u4f24\u6027\u8111\u635f\u4f24<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>\u6709\u7814\u7a76\u8868\u660e\uff0c\u521b\u4f24\u6027\u8111\u635f\u4f24\u4e5f\u53ef\u4ee5\u901a\u8fc7\u7ec6\u80de\u7597\u6cd5\u6cbb\u7597\uff0c\u4f7f\u7528<strong>WJ-MSC\u3001\u9aa8\u9ad3\u5355\u6838\u7ec6\u80de\u548c\u57fa\u56e0\u6539\u9020\u7684MSC<\/strong>\uff08\u88682\uff09\u3002<\/p>\n<figure class=\"wp-block-image size-full\">\n<p><div style=\"width: 1259px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/09\/20250924200055-68d3dd775f51d.png\" alt=\"\u88682\uff1a\u521b\u4f24\u6027\u8111\u635f\u4f24\u6cbb\u7597\u4e2d\u7684\u4e0d\u540c\u7ec6\u80de\u7c7b\u578b\" width=\"1249\" height=\"836\" title=\"\"><p class=\"wp-caption-text\">\u88682\uff1a\u521b\u4f24\u6027\u8111\u635f\u4f24\u6cbb\u7597\u4e2d\u7684\u4e0d\u540c\u7ec6\u80de\u7c7b\u578b<\/p><\/div><figcaption><\/figcaption><\/figure>\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E8%84%90%E5%B8%A6%E6%B2%83%E9%A1%BF%E8%83%B6%E6%9D%A5%E6%BA%90%E9%97%B4%E5%85%85%E8%B4%A8%E5%B9%B2%E7%BB%86%E8%83%9E%EF%BC%88WJ-MSCs%EF%BC%89%E6%B2%BB%E7%96%97%E5%88%9B%E4%BC%A4%E6%80%A7%E8%84%91%E6%8D%9F%E4%BC%A4\"><\/span><strong>\u8110\u5e26\u6c83\u987f\u80f6\u6765\u6e90\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08WJ-MSCs\uff09\u6cbb\u7597\u521b\u4f24\u6027\u8111\u635f\u4f24<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u5728\u810a\u9ad3\u635f\u4f24\u6cbb\u7597\u4e2d\u5df2\u663e\u793a\u51fa\u7597\u6548\u7684<strong>WJ-MSCs<\/strong>\uff0c\u81ea2020\u5e74\u8d77\u4e5f\u5f00\u59cb\u88ab\u63a2\u7d22\u7528\u4e8e\u521b\u4f24\u6027\u8111\u635f\u4f24\uff08TBI\uff09\u7684\u6cbb\u7597\u3002Kabatas\u7b49\u4eba\u9996\u6b21\u62a5\u9053\u4e86\u4e00\u4f8b TBI\u60a3\u8005\uff0c\u8be5\u60a3\u8005\u8868\u73b0\u4e3a\u56db\u80a2\u762b\u75ea\u3001\u4e25\u91cd\u808c\u75c9\u631b\u3001\u4e0d\u80fd\u8bf4\u8bdd\u53ca\u62ec\u7ea6\u808c\u5931\u63a7\u3002\u7814\u7a76\u4e2d\uff0c\u60a3\u8005\u5171\u63a5\u53d7<strong>6\u6b21\u7ed9\u836f<\/strong>\uff0c\u9014\u5f84\u5305\u62ec\u9798\u5185\u3001\u808c\u8089\u5185\u53ca\u9759\u8109\u6ce8\u5c04\uff0c\u6bcf\u6b21\u6ce8\u5c04\u5242\u91cf\u4e3a<strong>1\u00d710\u2076WJ-MSCs<\/strong>\u3002<\/p>\n<p>\u572812\u4e2a\u6708\u968f\u8bbf\u65f6\uff0c<strong>\u60a3\u8005\u7684<\/strong><strong>\u529f\u80fd\u72ec\u7acb\u6027\u8bc4\u4f30\uff08FIM\uff09\u8bc4\u5206<\/strong><strong>\u4ece22\/126\u63d0\u5347\u81f376\/126\uff0c<\/strong><strong>\u6539\u826fAshworth\u75c9\u631b\u91cf\u8868\uff08MAS\uff09<\/strong><strong>\u4ece44\u964d\u81f316<\/strong>\u3002\u672a\u62a5\u544a\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\u3002<\/p>\n<p>\u56db\u5e74\u540e\uff0c\u7814\u7a76\u56e2\u961f\u5f00\u5c55\u4e86\u4e00\u9879\u5305\u542b6\u540d\u60a3\u8005\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u91c7\u7528\u4e86\u7c7b\u4f3c\u7684\u6cbb\u7597\u65b9\u6848\uff0c\u5373\u901a\u8fc7\u9798\u5185\u3001\u808c\u8089\u5185\u53ca\u9759\u8109\u6ce8\u5c04<strong>1\u00d710\u2076WJ-MSCs<\/strong>\u3002<strong>\u6240\u6709\u53c2\u4e0e\u8005\u5728\u968f\u8bbf\u4e2d\u5747\u663e\u793a\u51fa<\/strong><strong>\u8ba4\u77e5\u80fd\u529b\u3001\u8fd0\u52a8\u6280\u80fd\uff08FIM\u8bc4\u5206\uff09\u3001\u808c\u75c9\u631b\u7a0b\u5ea6\uff08MAS\uff09\u3001\u808c\u529b\u53caKarnofsky\u8bc4\u5206<\/strong><strong>\u7684\u6539\u5584<\/strong>\u3002\u90e8\u5206\u60a3\u8005\u51fa\u73b0\u65e9\u671f\u77ed\u6682\u7684\u4e0d\u826f\u53cd\u5e94\uff0c\u5982\u4f4e\u70ed\u3001\u8f7b\u5ea6\u5934\u75db\u4ee5\u53ca\u56e0\u808c\u5185\u6ce8\u5c04\u5f15\u8d77\u7684\u808c\u8089\u75bc\u75db\u3002<\/p>\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E9%AA%A8%E9%AB%93%E5%8D%95%E4%B8%AA%E6%A0%B8%E7%BB%86%E8%83%9E%EF%BC%88BMMNCs%EF%BC%89%E6%B2%BB%E7%96%97%E5%88%9B%E4%BC%A4%E6%80%A7%E8%84%91%E6%8D%9F%E4%BC%A4\"><\/span><strong>\u9aa8\u9ad3\u5355\u4e2a\u6838\u7ec6\u80de\uff08BMMNCs\uff09\u6cbb\u7597\u521b\u4f24\u6027\u8111\u635f\u4f24<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>BMMNCs\u7684\u6cbb\u7597\u6f5c\u529b\u4e3b\u8981\u4f53\u73b0\u5728\u795e\u7ecf\u4fdd\u62a4\u548c\u6297\u708e\u673a\u5236\u4e0a\u3002\u57282017\u5e74\u7684I\/IIa\u671f\u4e34\u5e8a\u8bd5\u9a8c\u53d1\u73b0\uff0c\u9759\u8109\u8f93\u6ce8BMMNCs\u540e\uff0c\u6cbb\u7597\u7ec4\u60a3\u8005\u7684\u5e55\u4e0a\u8111\u4f53\u79ef\u5f97\u4ee5\u4fdd\u6301\uff0c\u5e76\u89c2\u5bdf\u5230\u5242\u91cf\u4f9d\u8d56\u6027\u7684\u708e\u6027\u56e0\u5b50\uff08\u5982TNF-\u03b1\uff09\u6291\u5236\uff0c\u63d0\u793a\u5176\u901a\u8fc7\u8c03\u8282\u708e\u75c7\u5fae\u73af\u5883\u53d1\u6325\u7597\u6548\u3002<\/p>\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E5%9F%BA%E5%9B%A0%E4%BF%AE%E9%A5%B0%E7%9A%84%E5%BC%82%E4%BD%93%E9%AA%A8%E9%AB%93%E9%97%B4%E5%85%85%E8%B4%A8%E5%B9%B2%E7%BB%86%E8%83%9E%EF%BC%88BM-MSCs%EF%BC%89%E6%B2%BB%E7%96%97%E5%88%9B%E4%BC%A4%E6%80%A7%E8%84%91%E6%8D%9F%E4%BC%A4\"><\/span><strong>\u57fa\u56e0\u4fee\u9970\u7684\u5f02\u4f53\u9aa8\u9ad3\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08BM-MSCs\uff09\u6cbb\u7597\u521b\u4f24\u6027\u8111\u635f\u4f24<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u57fa\u56e0\u5de5\u7a0b\u6539\u9020\u4e3a\u589e\u5f3a\u5e72\u7ec6\u80de\u7597\u6548\u63d0\u4f9b\u4e86\u7b56\u7565\u3002\u4e00\u9879II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u91c7\u7528\u7ecfNotch-1\u8f6c\u67d3\u7684\u5f02\u4f53BM-MSCs\uff08SB-623\uff09\uff0c\u901a\u8fc7\u7acb\u4f53\u5b9a\u5411\u624b\u672f\u8fdb\u884c\u9885\u5185\u6ce8\u5c04\u3002\u7ed3\u679c\u663e\u793a\uff0c<strong>\u6cbb\u7597\u7ec4\u60a3\u8005\u5728\u8fd0\u52a8\u529f\u80fd\uff08FMMS\u8bc4\u5206\uff09\u548c\u65e5\u5e38\u751f\u6d3b\u80fd\u529b\u65b9\u9762\u83b7\u5f97\u6301\u7eed\u6539\u5584\uff0c\u4e14\u6cbb\u7597\u5b89\u5168\u6027\u826f\u597d<\/strong>\uff0c\u4ee3\u8868\u4e86\u7ec6\u80de\u7597\u6cd5\u7cbe\u51c6\u5316\u3001\u9ad8\u6548\u5316\u7684\u53d1\u5c55\u65b9\u5411\u3002<\/p>\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E8%82%8C%E8%90%8E%E7%BC%A9%E4%BE%A7%E7%B4%A2%E7%A1%AC%E5%8C%96%E7%97%87\"><\/span><strong>\u5e72\u7ec6\u80de\u6cbb\u7597\u808c\u840e\u7f29\u4fa7\u7d22\u786c\u5316\u75c7<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>\u808c\u840e\u7f29\u4fa7\u7d22\u786c\u5316\u75c7 (ALS) \u7684\u5e38\u89c4\u6cbb\u7597\u53ef\u4ee5\u8f85\u4ee5\u7ec6\u80de\u7597\u6cd5\uff08\u88683\uff09\u3002<strong>\u80ce\u513f\u810a\u9ad3\u6765\u6e90\u7684\u795e\u7ecf\u5e72\u7ec6\u80de\u3001\u795e\u7ecf\u5e72\u7ec6\u80de\u6765\u6e90\u7684\u8fd0\u52a8\u795e\u7ecf\u5143\u3001\u80ce\u513f\u4eba\u7c7b\u795e\u7ecf\u5e72\u7ec6\u80de\u3001BM-MSC\u3001WJ-MSC\u4ee5\u53ca\u8fc7\u8868\u8fbeGDNF\u7684\u4eba\u7c7b\u80ce\u513f\u795e\u7ecf\u7956\u7ec6\u80de<\/strong>\u5728\u6cbb\u7597ALS\u65b9\u9762\u5df2\u663e\u793a\u51fa\u4e50\u89c2\u7684\u6548\u679c\u3002<\/p>\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/09\/20250924200055-68d3dd775f51d.png\" alt=\"\u88683\uff1a\u4e0d\u540c\u7ec6\u80de\u7c7b\u578b\u5728\u808c\u840e\u7f29\u4fa7\u7d22\u786c\u5316\u75c7\u4e2d\u7684\u6cbb\u7597\u6548\u679c\" width=\"1249\" height=\"836\" title=\"\"><figcaption><\/figcaption><\/figure>\n<figure class=\"wp-block-image size-full\">\n<p><div style=\"width: 1258px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/09\/20250924200055-68d3dd77ab3b9.png\" alt=\"\u88683\uff1a\u4e0d\u540c\u7ec6\u80de\u7c7b\u578b\u5728\u808c\u840e\u7f29\u4fa7\u7d22\u786c\u5316\u75c7\u4e2d\u7684\u6cbb\u7597\u6548\u679c\" width=\"1248\" height=\"541\" title=\"\"><p class=\"wp-caption-text\">\u88683\uff1a\u4e0d\u540c\u7ec6\u80de\u7c7b\u578b\u5728\u808c\u840e\u7f29\u4fa7\u7d22\u786c\u5316\u75c7\u4e2d\u7684\u6cbb\u7597\u6548\u679c<\/p><\/div><figcaption><\/figcaption><\/figure>\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E8%83%8E%E5%84%BF%E8%84%8A%E9%AB%93%E6%9D%A5%E6%BA%90%E7%9A%84%E7%A5%9E%E7%BB%8F%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E8%82%8C%E8%90%8E%E7%BC%A9%E4%BE%A7%E7%B4%A2%E7%A1%AC%E5%8C%96%E7%97%87\"><\/span><strong>\u80ce\u513f\u810a\u9ad3\u6765\u6e90\u7684\u795e\u7ecf\u5e72\u7ec6\u80de\u6cbb\u7597\u808c\u840e\u7f29\u4fa7\u7d22\u786c\u5316\u75c7<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u4e24\u9879\u57282014\u5e74\u548c2016\u5e74\u8fdb\u884c\u7684\u4e34\u5e8a\u8bd5\u9a8c\u63d0\u793a\uff0c\u5f02\u4f53\u80ce\u513f\u810a\u9ad3\u6765\u6e90\u7684\u795e\u7ecf\u5e72\u7ec6\u80de\u53ef\u7528\u4e8e\u9888\u9ad3\u8154\u5185\u79fb\u690d\u3002Feldman\u7b49\u4eba\u5f00\u5c55\u4e86\u4e00\u9879I\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5171\u7eb3\u51656\u540d\u60a3\u8005\uff0c\u6bcf\u6b21\u6ce8\u5c041.0\u00d710\u2075\u4e2a\u7ec6\u80de\u3002\u672f\u540e\u8bc4\u4f30\u91c7\u7528ALSFRS-R\u3001HHD\u548cEIM\u7b49\u6307\u6807\uff0c<strong>\u7ed3\u679c\u663e\u793a\u75be\u75c5\u8fdb\u5c55\u5e76\u672a\u52a0\u901f\uff0c\u5176\u4e2d\u63a5\u53d7\u9888\u9ad3\u6ce8\u5c04\u7684\u60a3\u8005\u75c5\u7a0b\u8fdb\u5c55\u751a\u81f3\u6709\u6240\u51cf\u7f13<\/strong>\u3002\u672a\u89c2\u5bdf\u5230\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\uff0c\u4ec5\u51fa\u73b0\u8f7b\u5fae\u7684\u56f4\u624b\u672f\u671f\u548c\u672f\u540e\u5e76\u53d1\u75c7\u3002<\/p>\n<p>\u540c\u6837\u5730\uff0cGlass\u7b49\u4eba\u5f00\u5c55\u4e86\u4e00\u9879I\/II\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u7eb3\u516515\u540d\u60a3\u8005\uff0c\u4f7f\u7528\u76f8\u540c\u7684\u7ec6\u80de\u7cfb\uff0c\u6ce8\u5c04\u6d53\u5ea6\u4e3a1.0\u20138.0\u00d710\u2075\u4e2a\u7ec6\u80de\/\u6b21\u3002\u6240\u6709\u60a3\u8005\u5747\u5728\u9888\u9ad3\u4e24\u4fa7\u63a5\u53d7\u6ce8\u5c04\uff0c\u5176\u4e2d\u4e00\u7ec4\u989d\u5916\u5728\u8170\u9ad3\uff08L2\u2013L4\uff09\u6c34\u5e73\u6ce8\u5c04\u3002\u7814\u7a76\u672a\u8bbe\u7acb\u81ea\u8eab\u5bf9\u7167\u7ec4\uff0c\u800c\u662f\u4e0e\u4e09\u7ec4\u5386\u53f2\u5bf9\u7167\u7ec4\u8fdb\u884c\u6bd4\u8f83\uff0c\u7ed3\u679c\u663e\u793a\u5b9e\u9a8c\u7ec4\u4e0e\u5bf9\u7167\u7ec4\u5728\u75be\u75c5\u8fdb\u5c55\u5e73\u5747\u901f\u7387\u4e0a\u65e0\u663e\u8457\u5dee\u5f02\u3002\u62a5\u544a\u7684\u4e0d\u826f\u4e8b\u4ef6\u5305\u62ec\u4e0e\u624b\u672f\u76f8\u5173\u7684\u77ed\u6682\u75bc\u75db\u4ee5\u53ca\u514d\u75ab\u6291\u5236\u5242\u5f15\u8d77\u7684\u526f\u4f5c\u7528\u3002<\/p>\n<h3 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class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Mazzini\u7b49\u4eba\u4e8e2015\u5e74\u548c2019\u5e74\u5206\u522b\u901a\u8fc7\u5bf96\u540d\u548c18\u540d\u60a3\u8005\u7684\u4e34\u5e8a\u8bd5\u9a8c\u63d0\u51fa\uff0c\u91c7\u7528\u80ce\u513f\u4eba\u7c7b\u795e\u7ecf\u5e72\u7ec6\u80de\u9776\u5411\u8170\u690e\u810a\u9ad3\u6cbb\u7597\u808c\u840e\u7f29\u4fa7\u7d22\u786c\u5316\uff08ALS\uff09\u3002\u5728\u521d\u6b65\u7814\u7a76\u4e2d\uff0c\u4ee57.5\u00d710\u2075\u7ec6\u80de\u6d53\u5ea6\u8fdb\u884c\u810a\u9ad3\u5185\u6ce8\u5c04\uff0c\u672f\u540e18\u4e2a\u6708\u968f\u8bbf\u672a\u89c2\u5bdf\u5230\u75be\u75c5\u8fdb\u5c55\u52a0\u901f\u7684\u8bc1\u636e\u3002<strong>6\u540d\u53c2\u4e0e\u8005\u4e2d\u67092\u4f8b\u8868\u73b0\u51faALS\u529f\u80fd\u8bc4\u5206\u91cf\u8868-\u4fee\u8ba2\u7248\uff08ALS-FRS-R\uff09\u884c\u8d70\u4e9a\u8bc4\u5206\u7684\u6682\u65f6\u6027\u6539\u5584<\/strong>\u3002<\/p>\n<p>\u8be5\u7814\u7a76\u4e2d\u67093\u540d\u62d2\u7edd\u63a5\u53d7\u7ecf\u76ae\u5185\u955c\u4e0b\u80c3\u9020\u53e3\u672f\u548c\u6709\u521b\u901a\u6c14\u6cbb\u7597\u7684\u60a3\u8005\u4e8e\u672f\u540e8\u4e2a\u6708\u6b7b\u4ea1\uff0c\u88ab\u8ba4\u4e3a\u4e0e\u75be\u75c5\u81ea\u7136\u8fdb\u5c55\u76f8\u5173\u3002\u5728\u7b2c\u4e8c\u9879\u8bd5\u9a8c\u4e2d\uff0c\u63a5\u53d74.5\u00d710\u2076\u7ec6\u80de\u810a\u9ad3\u5185\u6ce8\u5c04\u7684\u60a3\u8005\u968f\u8bbf\u65f6\u95f4\u957f\u8fbe60\u4e2a\u6708\uff0c<strong>\u672a\u53d1\u73b0\u4e0e\u6cbb\u7597\u76f8\u5173\u7684\u4e0d\u826f\u4e8b\u4ef6\u8bc1\u636e\u3002\u5728\u7ec6\u80de\u79fb\u690d\u540e\u7684\u7b2c\u4e00\u4e2a\u6708\u5185\u89c2\u5bdf\u5230ALS-FRS-R\u8bc4\u5206\u8fdb\u5c55\u51fa\u73b0\u663e\u8457\u6682\u65f6\u6027\u51cf\u7f13<\/strong>\uff0c\u8be5\u6548\u5e94\u6301\u7eed\u81f34\u4e2a\u6708\u3002<\/p>\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E8%87%AA%E4%BD%93%E9%97%B4%E5%85%85%E8%B4%A8%E5%B9%B2%E7%BB%86%E8%83%9E%EF%BC%88MSCs%EF%BC%89%E6%B2%BB%E7%96%97%E8%82%8C%E8%90%8E%E7%BC%A9%E4%BE%A7%E7%B4%A2%E7%A1%AC%E5%8C%96%E7%97%87\"><\/span><strong>\u81ea\u4f53\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09\u6cbb\u7597\u808c\u840e\u7f29\u4fa7\u7d22\u786c\u5316\u75c7<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><strong>Rushkevich\u56e2\u961f\u5f00\u5c55\u81ea\u4f53BM-MSCs\u6cbb\u7597\u808c\u840e\u7f29\u4fa7\u7d22\u786c\u5316\u75c7\u7684\u521d\u6b65\u63a2\u7d22\uff082015\u5e74\uff09\uff1a<\/strong>\u901a\u8fc7\u8170\u690e\u7a7f\u523a\u9014\u5f84\u5bf925\u4f8bALS\u60a3\u8005\u8fdb\u884c\u81ea\u4f53BM-MSCs\u8f93\u6ce8\u3002<strong>12\u4e2a\u6708\u968f\u8bbf\u663e\u793a\uff0c\u6cbb\u7597\u7ec410\u4f8b\u60a3\u8005\u75be\u75c5\u8fdb\u5c55\u901f\u5ea6\u663e\u8457\u51cf\u7f13<\/strong>\uff0c\u4e14\u672a\u51fa\u73b0\u660e\u663e\u4e0d\u826f\u53cd\u5e94\uff0c\u521d\u6b65\u8bc1\u5b9e\u4e86\u8be5\u7597\u6cd5\u7684\u5b89\u5168\u6027\u53ca\u6f5c\u5728\u5ef6\u7f13\u75be\u75c5\u8fdb\u5c55\u7684\u6548\u679c\u3002<\/p>\n<p><strong>Petrou\u56e2\u961f\u5f00\u5c55\u9798\u5185\u6ce8\u5c04\u5242\u91cf\u4f18\u5316\u7814\u7a76\uff082021\u5e74\uff09\uff1a<\/strong>\u91c7\u75281.0\u00d710\u2076\u7ec6\u80de\/\u516c\u65a4\u4f53\u91cd\u7684\u5242\u91cf\u5bf920\u4f8b\u60a3\u8005\u8fdb\u884c\u9798\u5185\u6ce8\u5c04\u3002<strong>\u7814\u7a76\u53d1\u73b0\u591a\u6b21\u6ce8\u5c04\u540e\u60a3\u8005ALSFRS-R\u8bc4\u5206\u6539\u5584\u7387\u6301\u7eed\u63d0\u5347\uff08\u9996\u6b21\u6ce8\u5c04\u540e73.7%\u7684\u60a3\u8005\u8fdb\u5c55\u7387\u6539\u5584\uff1e25%\uff09<\/strong>\uff0c\u4e14\u65e0\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\u62a5\u544a\uff0c\u63d0\u793a\u91cd\u590d\u7ed9\u836f\u53ef\u80fd\u589e\u5f3a\u7597\u6548\u3002<\/p>\n<p><strong>Berry\u56e2\u961fNurOwn\u00ae\u7ec6\u80de\u591a\u91cd\u7ed9\u836f\u9014\u5f84\u8bd5\u9a8c\uff082019\u5e74\uff09\uff1a<\/strong>\u901a\u8fc7\u9798\u5185\u4e0e\u808c\u8089\u6ce8\u5c04\u8054\u5408\u65b9\u5f0f\u7ed9\u836f\uff0c\u53d1\u73b0\u6cbb\u7597\u7ec4ALSFRS-R\u8bc4\u5206\u659c\u7387\u5728\u77ed\u671f\uff082\u5468\uff09\u5185\u663e\u8457\u6539\u5584\uff08+1.7\u5206\/\u6708\uff09\uff0c\u4f4611\u4f8b\u60a3\u8005\u51fa\u73b0\u5934\u75db\u3001\u80cc\u75db\u7b49\u4e0d\u826f\u53cd\u5e94\uff0c\u8868\u660e\u5c3d\u7ba1\u795e\u7ecf\u8425\u517b\u56e0\u5b50\u5206\u6ccc\u578b\u7ec6\u80de\u5177\u6709\u77ed\u671f\u7597\u6548\uff0c\u4f46\u9700\u5173\u6ce8\u75bc\u75db\u7c7b\u526f\u4f5c\u7528\u3002<\/p>\n<p><strong>Cudkowicz\u56e2\u961f\u5927\u89c4\u6a21\u2162\u671f\u9a8c\u8bc1\u7814\u7a76NurOwn\u00ae\u7ec6\u80de\u6cbb\u7597ALS\u7684\u7597\u6548\uff082022\u5e74\uff09\uff1a<\/strong>\u5bf9196\u4f8b\u60a3\u8005\u8fdb\u884c\u9ad8\u6d53\u5ea6\u9798\u5185\u6ce8\u5c04\uff08125\u00d710\u2076\u7ec6\u80de\uff09\u3002\u867d\u7136\u6cbb\u7597\u7ec4\u5728\u795e\u7ecf\u708e\u75c7\u6807\u5fd7\u7269\u548c\u795e\u7ecf\u8425\u517b\u56e0\u5b50\u6c34\u5e73\u663e\u8457\u6539\u5584\uff0c\u4f46\u672a\u8fbe\u5230\u4e3b\u8981\u4e34\u5e8a\u7ec8\u70b9\uff0c\u4e14\u75bc\u75db\u6210\u4e3a\u666e\u904d\u4e0d\u826f\u53cd\u5e94\uff0c\u63d0\u793a\u751f\u7269\u6807\u5fd7\u7269\u6539\u5584\u672a\u5fc5\u8f6c\u5316\u4e3a\u4e34\u5e8a\u7ec8\u70b9\u83b7\u76ca\uff0c\u4e9f\u9700\u4f18\u5316\u6cbb\u7597\u7b56\u7565\u3002<\/p>\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E6%B2%83%E9%A1%BF%E8%83%B6%E6%BA%90%E9%97%B4%E5%85%85%E8%B4%A8%E5%B9%B2%E7%BB%86%E8%83%9E%EF%BC%88WJ-MSCs%EF%BC%89%E6%B2%BB%E7%96%97%E8%82%8C%E8%90%8E%E7%BC%A9%E4%BE%A7%E7%B4%A2%E7%A1%AC%E5%8C%96%E7%97%87\"><\/span><strong>\u6c83\u987f\u80f6\u6e90\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08WJ-MSCs\uff09\u6cbb\u7597\u808c\u840e\u7f29\u4fa7\u7d22\u786c\u5316\u75c7<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Barczewska\u7b49\u4eba\u901a\u8fc7\u4e00\u9879\u75c5\u4f8b\u5bf9\u7167\u7814\u7a76\u8bc1\u5b9e\uff0c\u9798\u5185\u6ce8\u5c04WJ-MSCs\u5bf9\u6cbb\u7597\u808c\u840e\u7f29\u4fa7\u7d22\u786c\u5316\uff08ALS\uff09\u60a3\u8005\u5177\u6709\u6cbb\u7597\u6f5c\u529b\u3002\u8be5\u7814\u7a76\u5171\u7eb3\u516567\u4f8b\u60a3\u8005\uff0c\u6cbb\u7597\u7ec4\u6309\u6bcf\u6b21\u6ce8\u5c0430\u00d710\u2076\u7ec6\u80de\u7684\u5242\u91cf\u7ed9\u836f\u3002\u6240\u6709\u7ec4\u7684\u4e2d\u4f4d\u751f\u5b58\u65f6\u95f4\u5747\u5b9e\u73b0\u7ffb\u500d\uff0c\u5176\u4e2d67\u4f8b\u60a3\u8005\u4e2d21\u4f8b\u75be\u75c5\u8fdb\u5c55\u901f\u5ea6\u51cf\u7f13\uff0c33\u4f8b\u8fdb\u5c55\u901f\u5ea6\u65e0\u53d8\u5316\uff0c13\u4f8b\u51fa\u73b0\u8fdb\u5c55\u52a0\u901f\u3002\u7814\u7a76\u4e2d\u672a\u62a5\u544a\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\u3002<\/p>\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E8%BF%87%E8%A1%A8%E8%BE%BEGDNF%E7%9A%84%E8%83%8E%E5%84%BF%E7%A5%9E%E7%BB%8F%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E8%82%8C%E8%90%8E%E7%BC%A9%E4%BE%A7%E7%B4%A2%E7%A1%AC%E5%8C%96%E7%97%87\"><\/span><strong>\u8fc7\u8868\u8fbeGDNF\u7684\u80ce\u513f\u795e\u7ecf\u5e72\u7ec6\u80de\u6cbb\u7597\u808c\u840e\u7f29\u4fa7\u7d22\u786c\u5316\u75c7<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Baloh\u7b49\u4eba\u4e8e2022\u5e74\u62a5\u544a\u4e86\u4e00\u98791\/2a\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u4f7f\u7528\u7ecf\u80f6\u8d28\u7ec6\u80de\u6e90\u6027\u795e\u7ecf\u8425\u517b\u56e0\u5b50\uff08GDNF\uff09\u57fa\u56e0\u8f6c\u5bfc\u7684\u80ce\u513f\u795e\u7ecf\u5e72\u7ec6\u80de\uff08CNS10-NPC-GDNF\uff09\u8fdb\u884c\u6cbb\u7597\u300218\u540d\u53c2\u4e0e\u8005\u88ab\u5206\u4e3a\u4e24\u7ec4\uff1aA\u7ec4\u63a5\u53d70.2\u00d710\u2076\u4e2aCNS10-NPC-GDNF\u7ec6\u80de\u6cbb\u7597\uff1bB\u7ec4\u63a5\u53d70.5\u00d710\u2076\u4e2a\u7ec6\u80de\u6cbb\u7597\u3002\u7ec6\u80de\u88ab\u6ce8\u5c04\u5230\u8170\u690e\u810a\u9ad3\u80cc\u89d2\u4e0e\u8179\u89d2\u4e4b\u95f4\u7684\u8fc7\u6e21\u533a\u3002<\/p>\n<p>\u5c3d\u7ba1\u6cbb\u7597\u7ec4\u5728\u80eb\u9aa8\u524d\u808c\u590d\u5408\u808c\u8089\u52a8\u4f5c\u7535\u4f4d\uff08CMAP\uff09\u548c\u7535\u963b\u6297\u808c\u52a8\u56fe\uff08EIM\uff09\u65b9\u9762\u672a\u89c2\u5bdf\u5230\u663e\u8457\u53d8\u5316\uff0c\u4f46\u63a5\u53d7\u6cbb\u7597\u7684\u817f\u90e8\u529b\u91cf\u4e27\u5931\u901f\u5ea6\u5e73\u5747\u6162\u4e8e\u672a\u6cbb\u7597\u7684\u817f\u90e8\u3002\u672a\u62a5\u544a\u4e0e\u6ce8\u5c04\u7ec6\u80de\u76f8\u5173\u7684\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\u3002<\/p>\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E8%AE%A8%E8%AE%BA%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E7%A5%9E%E7%BB%8F%E5%88%9B%E4%BC%A4%E5%92%8C%E7%A5%9E%E7%BB%8F%E9%80%80%E8%A1%8C%E6%80%A7%E7%96%BE%E7%97%85%E7%9A%84%E4%B8%B4%E5%BA%8A%E7%96%97%E6%95%88\"><\/span><strong>\u8ba8\u8bba\u5e72\u7ec6\u80de\u6cbb\u7597\u795e\u7ecf\u521b\u4f24\u548c\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u7684\u4e34\u5e8a\u7597\u6548<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>\u672c\u7814\u7a76\u662f\u7b2c\u4e00\u4efd\u5168\u9762\u3001\u6bd4\u8f83\u5730\u6982\u8ff0\u7ec6\u80de\u7597\u6cd5\u5728\u6cbb\u7597\u810a\u9ad3\u635f\u4f24\u3001\u8111\u5916\u4f24\u548c\u808c\u840e\u7f29\u4fa7\u7d22\u786c\u5316\u75c7\u7b49\u5404\u79cd\u795e\u7ecf\u5eb7\u590d\u75be\u75c5\u7684\u89c4\u683c\u548c\u7597\u6548\u7684\u6700\u65b0\u53d1\u5c55\u7684\u7efc\u8ff0\uff0c\u4e3b\u8981\u5173\u6ce8\u8fc7\u53bb\u5341\u5e74\uff082014\u5e74\u81f32024\u5e74\uff09\u53d1\u8868\u7684\u7814\u7a76\u3002<\/p>\n<p><strong>\u7ec6\u80de\u7597\u6cd5\u5728\u795e\u7ecf\u521b\u4f24\u6027\u75be\u75c5\u4e2d\u7684\u7597\u6548\uff1a<\/strong>\u5bf9\u4e8e\u810a\u9ad3\u635f\u4f24\u7684\u6cbb\u7597\uff0c\u9aa8\u9ad3\u6765\u6e90\u7ec6\u80de\u548c\u795e\u7ecf\uff08\u7956\uff09\u5e72\u7ec6\u80de\u662f\u4e24\u79cd\u8868\u73b0\u51fa\u663e\u8457\u6f5c\u529b\u7684\u7ec6\u80de\u7c7b\u578b\u3002\u5176\u7597\u6548\u4e3b\u8981\u4f53\u73b0\u5728\u7f8e\u56fd\u810a\u9ad3\u635f\u4f24\u534f\u4f1a\uff08AIS\uff09\u5206\u7ea7\u6539\u5584\u3001\u611f\u89c9\u4e0e\u8fd0\u52a8\u529f\u80fd\u6062\u590d\u4ee5\u53ca\u8180\u80f1\u548c\u809b\u95e8\u63a7\u5236\u80fd\u529b\u63d0\u5347\u7b49\u65b9\u9762\uff08\u56fe2\uff09\u3002<\/p>\n<figure class=\"wp-block-image size-full\">\n<p><div style=\"width: 2040px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/09\/20250924200055-68d3dd77e02ca.png\" alt=\"\u56fe2\uff1a\u9aa8\u9ad3\u6709\u6838\u7ec6\u80de\u548c\u9aa8\u9ad3\u95f4\u5145\u8d28\u7ec6\u80de\u5728\u795e\u7ecf\u521b\u4f24\u548c\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u4e2d\u7684\u6f5c\u5728\u6cbb\u7597\u6548\u679c\" width=\"2030\" height=\"912\" title=\"\"><p class=\"wp-caption-text\">\u56fe2\uff1a\u9aa8\u9ad3\u6709\u6838\u7ec6\u80de\u548c\u9aa8\u9ad3\u95f4\u5145\u8d28\u7ec6\u80de\u5728\u795e\u7ecf\u521b\u4f24\u548c\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u4e2d\u7684\u6f5c\u5728\u6cbb\u7597\u6548\u679c<\/p><\/div><figcaption><\/figcaption><\/figure>\n<p>\u7814\u7a76\u8868\u660e\uff0c\u81ea\u4f53\u9aa8\u9ad3\u6765\u6e90\u7ec6\u80de\u5bf9\u9888\u690e\u3001\u80f8\u690e\u548c\u8170\u690e\u7b49\u51e0\u4e4e\u6240\u6709\u8282\u6bb5\u7684\u810a\u9ad3\u635f\u4f24\u5747\u5177\u6709\u6cbb\u7597\u6548\u679c\uff0c\u591a\u9879\u4e34\u5e8a\u8bd5\u9a8c\u5747\u89c2\u5bdf\u5230\u60a3\u8005AIS\u5206\u7ea7\u83b7\u5f97\u81f3\u5c11\u4e00\u7ea7\u6216\u591a\u7ea7\u7684\u6539\u5584\u3002<\/p>\n<p>\u8fd9\u4e24\u79cd\u7ec6\u80de\u5747\u901a\u8fc7\u9798\u5185\u6ce8\u5c04\u9014\u5f84\u7ed9\u836f\uff0c\u4f46\u9488\u5bf9\u7684\u635f\u4f24\u8282\u6bb5\u5b58\u5728\u5dee\u5f02\u3002\u9aa8\u9ad3\u6765\u6e90\u7ec6\u80de\u5e7f\u6cdb\u9002\u7528\u4e8e\u5404\u8282\u6bb5\u635f\u4f24\uff0c\u800c\u540c\u79cd\u5f02\u4f53\u795e\u7ecf\u5e72\u7ec6\u80de\u5219\u4e3b\u8981\u5e94\u7528\u4e8e\u8f83\u9ad8\u8282\u6bb5\u7684\u9888\u80f8\u6bb5\u810a\u9ad3\u635f\u4f24\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u5c3d\u7ba1\u7ed9\u836f\u65b9\u5f0f\u4e00\u81f4\uff0c\u4f46\u4e0d\u540c\u7ec6\u80de\u7c7b\u578b\u7684\u4f5c\u7528\u673a\u5236\u548c\u957f\u671f\u6548\u679c\u5404\u6709\u7279\u70b9\u3002<\/p>\n<p><strong>\u7ec6\u80de\u6cbb\u7597\u5728\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u4e2d\u7684\u7597\u6548\uff1a<\/strong>\u5728\u808c\u840e\u7f29\u4fa7\u7d22\u786c\u5316\u75c7\uff08ALS\uff09\u7684\u6cbb\u7597\u4e2d\uff0c\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u548c\u795e\u7ecf\u5e72\u7ec6\u80de\u5df2\u88ab\u8bc1\u660e\u53ef\u6709\u6548\u4fc3\u8fdb\u60a3\u8005\u5eb7\u590d\u3002ALS\u75be\u75c5\u8fdb\u5c55\u51cf\u7f13\uff0c\u4ee5\u53ca\u6839\u636e\u4fee\u8ba2\u7248 ALS\u529f\u80fd\u8bc4\u5b9a\u91cf\u8868 (RERS) \u8bc4\u4f30\u7684\u75be\u75c5\u8fdb\u5c55\u52a0\u901f\u6539\u5584\u6216\u6d88\u5931\uff0c\u8bc1\u660e\u4e86\u8be5\u7597\u6cd5\u7684\u6709\u6548\u6027\u3002<\/p>\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E7%A5%9E%E7%BB%8F%E9%80%80%E8%A1%8C%E6%80%A7%E7%96%BE%E7%97%85%E7%9A%84%E7%96%97%E6%95%88%E6%9C%BA%E5%88%B6%E4%B8%8E%E7%BB%BC%E5%90%88%E6%BD%9C%E5%8A%9B\"><\/span><strong><span class=\"xintheme_tag_link\">\u5e72\u7ec6\u80de\u6cbb\u7597\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5<\/span>\u7684\u7597\u6548\u673a\u5236\u4e0e\u7efc\u5408\u6f5c\u529b<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u5e72\u7ec6\u80de\u6cbb\u7597\u795e\u7ecf\u75be\u75c5\u7684\u7597\u6548\u53ef\u80fd\u4e3b\u8981\u5f52\u56e0\u4e8e\u5176\u5f3a\u5927\u7684\u514d\u75ab\u8c03\u8282\u4e0e\u795e\u7ecf\u8425\u517b\u4f5c\u7528\uff0c\u800c\u975e\u7b80\u5355\u7684\u7ec6\u80de\u66ff\u4ee3\u3002\u5b83\u4eec\u901a\u8fc7\u91ca\u653e\u6297\u708e\u7ec6\u80de\u56e0\u5b50\uff08\u5982IL-10\uff09\uff0c\u8bf1\u5bfcM2\u578b\u5de8\u566c\u7ec6\u80de\/\u5c0f\u80f6\u8d28\u7ec6\u80de\u6d3b\u5316\uff0c\u5e76\u6291\u5236TNF-\u03b1\u3001IL-1\u03b2\u7b49\u4fc3\u708e\u56e0\u5b50\uff0c\u4ece\u800c\u51cf\u8f7b\u7ee7\u53d1\u6027\u795e\u7ecf\u635f\u4f24\u3001\u521b\u9020\u518d\u751f\u5fae\u73af\u5883\u3002<\/p>\n<p>\u540c\u65f6\uff0c\u5206\u6ccc\u7684\u591a\u79cd\u795e\u7ecf\u8425\u517b\u56e0\u5b50\u652f\u6301\u4e86\u73b0\u5b58\u795e\u7ecf\u5143\u7684\u5b58\u6d3b\u548c\u8f74\u7a81\u4fee\u590d\u3002MSCs\u7684\u65c1\u5206\u6ccc\u6548\u5e94\u548cNSCs\u7684\u5206\u5316\u6f5c\u80fd\u76f8\u7ed3\u5408\uff0c\u53ef\u80fd\u662f\u672a\u6765\u4f18\u5316\u6cbb\u7597\u7b56\u7565\u7684\u65b9\u5411\u3002<\/p>\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E7%A0%94%E7%A9%B6%E7%9A%84%E5%B1%80%E9%99%90%E6%80%A7%E4%B8%8E%E6%8C%91%E6%88%98\"><\/span><strong>\u7814\u7a76\u7684\u5c40\u9650\u6027\u4e0e\u6311\u6218<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u5c3d\u7ba1\u7ed3\u679c\u9f13\u821e\u4eba\u5fc3\uff0c\u4f46\u8be5\u9886\u57df\u4ecd\u9762\u4e34\u663e\u8457\u6311\u6218\uff0c\u9650\u5236\u4e86\u7814\u7a76\u7ed3\u8bba\u7684\u666e\u9002\u6027\u3002<\/p>\n<ul class=\"wp-block-list\">\n<li><strong>\u5f02\u8d28\u6027\u9ad8\uff1a<\/strong>\u5404\u7814\u7a76\u5728\u7ed9\u836f\u9014\u5f84\u3001\u7ec6\u80de\u5242\u91cf\u3001\u6d53\u5ea6\u3001\u6765\u6e90\uff08\u81ea\u4f53\/\u5f02\u4f53\uff09\u3001\u5236\u5907\u6d41\u7a0b\u548c\u4ea7\u54c1\u72b6\u6001\uff08\u65b0\u9c9c\/\u51bb\u5b58\uff09\u4e0a\u5b58\u5728\u5de8\u5927\u5dee\u5f02\u3002<\/li>\n<li><strong>\u6837\u672c\u91cf\u5c0f\uff1a<\/strong>\u5927\u591a\u6570\u7814\u7a76\u6837\u672c\u91cf\u6709\u9650\uff08n&lt;25\uff09\uff0c\u7edf\u8ba1\u6548\u80fd\u4e0d\u8db3\u3002<\/li>\n<li><strong>\u8bc4\u4f30\u6807\u51c6\u4e0d\u4e00\uff1a<\/strong>\u9664AIS\u5206\u7ea7\u5916\uff0c\u90e8\u5206\u7814\u7a76\u4f7f\u7528ISNCSCI\u3001FIM\u3001ALSFRS-R\u3001GRASSP\u7b49\u591a\u79cd\u8bc4\u4f30\u5de5\u5177\uff0c\u5bfc\u81f4\u7ed3\u679c\u96be\u4ee5\u76f4\u63a5\u6bd4\u8f83\u3002<\/li>\n<li><strong>\u7f3a\u4e4f\u6807\u51c6\u5316\uff1a<\/strong>\u5728\u7ec6\u80de\u5236\u5907\u3001\u5206\u5316\u65b9\u6cd5\u548c\u751f\u4ea7\u6807\u51c6\u4e0a\u7f3a\u4e4f\u56fd\u9645\u5171\u8bc6\uff0c\u662f\u5bfc\u81f4\u7ed3\u679c\u4e0d\u4e00\u81f4\u7684\u4e3b\u8981\u539f\u56e0\u3002<\/li>\n<\/ul>\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E5%AE%89%E5%85%A8%E9%97%AE%E9%A2%98\"><\/span><strong>\u5b89\u5168\u95ee\u9898<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u603b\u4f53\u800c\u8a00\uff0c\u591a\u6570\u7ec6\u80de\u7597\u6cd5\u8010\u53d7\u6027\u826f\u597d\u3002\u7136\u800c\uff0c\u4ecd\u9700\u8b66\u60d5\u53ef\u80fd\u7684\u4e0d\u826f\u4e8b\u4ef6\u3002\u5728SCI\u6cbb\u7597\u4e2d\uff0c\u5305\u62ec\u810a\u9ad3\u51fa\u8840\u6027\u574f\u6b7b\u3001\u8111\u810a\u6db2\u6f0f\u3001\u5047\u6027\u8111\u819c\u81a8\u51fa\u7b49\u4e25\u91cd\u624b\u672f\u76f8\u5173\u98ce\u9669\uff0c\u4ee5\u53ca\u611f\u67d3\u3001\u8840\u80bf\u3001\u5934\u75db\u548c\u6076\u5fc3\u7b49\u8f7b\u5ea6\u4e0d\u826f\u53cd\u5e94\u3002<\/p>\n<p>\u5728ALS\u6cbb\u7597\u4e2d\uff0c\u5934\u75db\u3001\u80cc\u75db\u7b49\u75bc\u75db\u53cd\u5e94\u8f83\u4e3a\u5e38\u89c1\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u75be\u75c5\u81ea\u7136\u8fdb\u5c55\u76f8\u5173\u7684\u4e25\u91cd\u4e8b\u4ef6\uff08\u5982\u6b7b\u4ea1\uff09\u9700\u4e0e\u6cbb\u7597\u76f8\u5173\u526f\u4f5c\u7528\u4ed4\u7ec6\u533a\u5206\u3002\u5728\u4e25\u683c\u76d1\u63a7\u4e0b\uff0c\u5f53\u524d\u8bc1\u636e\u8868\u660e\u7ec6\u80de\u7597\u6cd5\u7684\u6f5c\u5728\u6536\u76ca\u53ef\u80fd\u8d85\u8d8a\u5176\u98ce\u9669\u3002<\/p>\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E6%9C%AA%E6%9D%A5%E6%88%91%E4%BB%AC%E5%BA%94%E8%AF%A5%E6%80%8E%E4%B9%88%E5%81%9A%EF%BC%9F\"><\/span><strong>\u672a\u6765\u6211\u4eec\u5e94\u8be5\u600e\u4e48\u505a\uff1f<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u672a\u6765\u7814\u7a76\u5e94\u4ece\u4ee5\u4e0b\u65b9\u5411\u91cd\u70b9\u7a81\u7834\uff1a<\/p>\n<ul 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class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\"><p>\u53c2\u8003\u8d44\u6599\uff1a[1]:Ku, J.B., Pak, R.J., Ku, S.S.\u00a0<em>et al.<\/em>\u00a0Clinical Efficacy of Stem Cell Therapy in Neurotraumatic and Neurodegenerative Conditions: A Comparative Review.\u00a0<em>Tissue Eng Regen Med<\/em>\u00a0(2025). 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