{"id":19207,"date":"2025-09-25T04:01:39","date_gmt":"2025-09-24T12:01:39","guid":{"rendered":"https:\/\/www.hjtdsm.cn\/stem-cells\/stem-cell-therapy\/19207.html"},"modified":"2025-10-13T15:51:23","modified_gmt":"2025-10-13T07:51:23","slug":"https-www-hjtdsm-cn-stem-cells-stem-cell-therapy-19207-html","status":"publish","type":"post","link":"https:\/\/www.hjtdsm.cn\/ar\/stem-cells\/stem-cell-therapy\/19207.html","title":{"rendered":"\u0627\u0644\u0639\u0644\u0627\u062c \u0628\u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062c\u0630\u0639\u064a\u0629 \u0644\u0646\u0642\u0635 \u062a\u0631\u0648\u064a\u0629 \u0627\u0644\u0623\u0637\u0631\u0627\u0641 \u0627\u0644\u062d\u0627\u062f: \u0627\u0644\u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u0623\u0648\u0644\u0649 \u0645\u0646 \u0627\u0644\u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u062a\u064f\u0638\u0647\u0631 \u0633\u0644\u0627\u0645\u0629 \u0648\u062c\u062f\u0648\u0649 \u0627\u0644\u0639\u0644\u0627\u062c | \u0623\u0645\u0644 \u0627\u0644\u0645\u0631\u0636\u0649"},"content":{"rendered":"

\u8fd1\u671f\uff0c\u56fd\u9645\u671f\u520a\u300aStem Cell Research & Therapy<\/a>\u300b\u520a\u767b\u4e86\u4e00\u9879\u7531Zeinab Shirbaghaee\u56e2\u961f\u4e3b\u5bfc\u76841\u671f\u4e34\u5e8a\u7814\u7a76\uff0c\u8be5\u8bd5\u9a8c\u63a2\u7d22\u4e86\u91c7\u7528\u80ce\u76d8\u6765\u6e90\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09\u6cbb\u7597\u4e25\u91cd\u80a2\u4f53\u7f3a\u8840\uff08CLI\uff09\u60a3\u8005\u7684\u53ef\u884c\u6027\u4e0e\u521d\u6b65\u7597\u6548\uff08\u8bd5\u9a8c\u6ce8\u518c\u53f7\uff1aIRCT20210221050446N1\uff09[1]<\/sup>\u3002<\/p>\n

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\u0627\u0644\u0639\u0644\u0627\u062c \u0628\u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062c\u0630\u0639\u064a\u0629<\/span>\u4e25\u91cd\u80a2\u4f53\u7f3a\u8840\uff1aI\u671f\u4e34\u5e8a\u8bd5\u9a8c\u62a5\u544a\u5b89\u5168\u6027\u4e0e\u53ef\u884c\u6027 | \u60a3\u8005\u5e0c\u671b<\/strong><\/h1>\n

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\"\u5e72\u7ec6\u80de\u6cbb\u7597\u4e25\u91cd\u80a2\u4f53\u7f3a\u8840\uff1aI\u671f\u4e34\u5e8a\u8bd5\u9a8c\u62a5\u544a\u5b89\u5168\u6027\u4e0e\u53ef\u884c\u6027<\/figure>\n

\u65b9 \u6cd5\uff1a<\/strong>\u6839\u636e\u8bd5\u9a8c\u987a\u5e8f\uff0c\u7814\u7a76\u4eba\u5458\u5c06\u7b26\u5408\u6761\u4ef6\u7684\u60a3\u8005\u968f\u673a\u5206\u5165\u4e24\u4e2aMSCs\u7ec4\uff0c\u91c7\u75283 + 3\u5242\u91cf\u9012\u589e\u65b9\u6cd5\uff0c\u6bcf\u4e2aMSCs\u5242\u91cf\u961f\u5217\u67093-6\u540d\u60a3\u8005\uff1a20 \u00d7 106\u4e2a\u7ec6\u80de\uff08\u4f4e\u5242\u91cf\uff09\u548c60 \u00d7 106\u4e2a\u7ec6\u80de\uff08\u9ad8\u5242\u91cf\uff09\u3002<\/p>\n

\u5728\u810a\u9ad3\u9ebb\u9189\uff083\u540d\u60a3\u8005\uff09\u548c\u9759\u8109\u9547\u9759\u4e0b\uff086\u540d\u60a3\u8005\uff09\u6ce8\u5c04MSCs\uff0c\u6cbb\u7597\u52062\u4e2a\u65f6\u95f4\u70b9\u8fdb\u884c\uff0c\u95f4\u96948\u5468\u3002\u4f7f\u752830G\u9488\u5934\u5c06MSCs\u60ac\u6db2\u808c\u8089\u6ce8\u5c04\u81f3\u6df1\u5ea61-1.5 cm\u3001\u9762\u79ef10 \u00d7 6 cm\uff0830-40\u4e2a\u90e8\u4f4d\uff0c\u6bcf\u4e2a\u90e8\u4f4d0.5-1.0 ml MSCs\uff09\u3002<\/p>\n

\"\"<\/figure>\n

\u7ed3\u679c\uff1a\u2460\u514d\u75ab\u5b66\u7279\u5f81\u53d8\u5316\uff1a<\/strong>\u6cbb\u7597\u540e6\u4e2a\u6708\u7684\u968f\u8bbf\u671f\u5185\uff0cIL-1\u548cIFN-\u03b3\u8840\u6e05\u6c34\u5e73\u663e\u8457\u964d\u4f4e\uff08P \u02c2 0.05\uff0c\u56fe3\uff09\u3002\u5728MSCs\u6cbb\u7597\u524d\u540e\uff0c\u4f7f\u7528\u6d41\u5f0f\u7ec6\u80de\u672f\u5206\u6790\u60a3\u8005\u8840\u6db2\u6837\u672c\u4e2d\u7684CD4\u3001CD8\u548cCD25\u6807\u8bb0\u7269\uff08\u56fe4\uff09\uff0c\u6ca1\u6709\u89c2\u5bdf\u5230\u660e\u663e\u7684\u53d8\u5316\u3002\u8fd9\u9879\u7ed3\u679c\u8868\u660e\uff0cCLI\u60a3\u8005\u7684\u514d\u75ab\u7279\u5f81\u6ca1\u6709\u53d7\u5230\u540c\u79cd\u5f02\u4f53MSCs\u6cbb\u7597\u7684\u4e0d\u5229\u5f71\u54cd\u3002<\/p>\n

\"\"<\/figure>\n

\u2461\u8840\u7ba1\u751f\u6210\uff1a<\/strong>\u7ec6\u80de\u8f93\u6ce86\u4e2a\u6708\u540e\uff0c\u4fa7\u652f\u8840\u7ba1\u5f62\u6210\u8bc4\u5206\u5347\u81f30.98\u00b10.3\uff08\u56fe5\uff0c+0\uff08\u65e0\u4fa7\u652f\u5faa\u73af\uff09\u3001+1\uff08\u8f7b\u5fae\uff09\u4fa7\u652f\u5faa\u73af\uff09\u3001+ 2\uff08\u4e2d\u5ea6\u4fa7\u652f\u5faa\u73af\uff09\u548c + 3\uff08\u9ad8\u4fa7\u652f\u5faa\u73af\uff09\uff09\u3002<\/p>\n

\"\"<\/figure>\n

\u2462\u75bc\u75db\u7f13\u89e3\uff1a<\/strong>\u4f7f\u7528VAS\u8bc4\u4f30\u9759\u606f\u75bc\u75db\uff0c\u5728\u5b8c\u6210\u968f\u8bbf\u671f\u7684\u60a3\u8005\u4e2d\uff0c\u75bc\u75db\u5747\u663e\u793a\u51fa\u663e\u7740\u6539\u5584\uff08\u56fe6A\uff09\u3002\u5e73\u5747VAS\u57fa\u7ebf\u8bc4\u5206\u4e3a8\uff08\u00b10.75\uff09\uff0c3\u4e2a\u6708\u540e\u6539\u5584\u81f33.87\uff08\u00b11.24\uff09\uff0c6\u4e2a\u6708\u540e\u6539\u5584\u81f31.125\uff080.83\uff09\u3002<\/p>\n

\"\"<\/figure>\n

\u2463VascuQoL-6\u53d8\u5316\uff1a<\/strong>\u6cbb\u7597\u540e\u5065\u5eb7\u76f8\u5173\u7684\u751f\u6d3b\u8d28\u91cf\u6709\u663e\u8457\u6539\u5584\uff08P\u02c20.0001\uff0c\u56fe6D\uff09\uff0c\u7279\u522b\u662f\u8fde\u7eed\u6b65\u884c\u4ee5\u53ca\u9547\u75db\u836f\u7684\u4f7f\u7528\u91cf\u663e\u8457\u51cf\u5c11\u3002<\/p>\n

\"\"<\/figure>\n

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\n

\u53c2\u8003\u6587\u732e\uff1a<\/b><\/b><\/p>\n

[1]:Shirbaghaee, Z., Heidari Keshel, S., Rasouli, M.\u00a0et al.<\/em>\u00a0Report of a phase 1 clinical trial for safety assessment of human placental mesenchymal stem cells therapy in patients with critical limb ischemia (CLI).\u00a0Stem Cell Res Ther<\/em>\u00a014<\/strong>, 174 (2023). https:\/\/doi.org\/10.1186\/s13287-023-03390-9<\/p>\n

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