{"id":19709,"date":"2025-10-16T15:41:58","date_gmt":"2025-10-16T07:41:58","guid":{"rendered":"https:\/\/www.hjtdsm.cn\/?p=19709"},"modified":"2025-10-16T15:41:58","modified_gmt":"2025-10-16T07:41:58","slug":"%e5%b9%b2%e7%bb%86%e8%83%9e%e6%b2%bb%e7%96%97%e8%83%bd%e6%94%b9%e5%96%84%e5%b8%95%e9%87%91%e6%a3%ae%e6%82%a3%e8%80%85%e7%9a%84%e8%82%be%e5%8a%9f%e8%83%bd%e5%90%97%ef%bc%9f%e7%a0%94%e7%a9%b6%e6%98%be","status":"publish","type":"post","link":"https:\/\/www.hjtdsm.cn\/ar\/stem-cells\/stem-cell-therapy\/19709.html","title":{"rendered":"\u0647\u0644 \u064a\u0645\u0643\u0646 \u0644\u0644\u0639\u0644\u0627\u062c \u0628\u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062c\u0630\u0639\u064a\u0629 \u062a\u062d\u0633\u064a\u0646 \u0648\u0638\u0627\u0626\u0641 \u0627\u0644\u0643\u0644\u0649 \u0644\u062f\u0649 \u0645\u0631\u0636\u0649 \u0628\u0627\u0631\u0643\u0646\u0633\u0648\u0646\u061f \u062f\u0631\u0627\u0633\u0629 \u062a\u064f\u0638\u0647\u0631 \u0623\u0646 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062c\u0630\u0639\u064a\u0629 \u0627\u0644\u0635\u0644\u0628\u0629 \u0627\u0644\u0643\u0627\u0641\u064a\u0629 \u062a\u064f\u062d\u0633\u0651\u0646 \u0645\u0639\u062f\u0644 \u0625\u0641\u0631\u0627\u0632 \u0627\u0644\u0643\u0644\u0649 \u0641\u064a \u0627\u0644\u062f\u0645 \u0648\u062a\u0642\u0644\u0644 \u0645\u0646 \u0627\u0644\u0643\u0631\u064a\u0627\u062a\u064a\u0646\u064a\u0646\u064a\u0646 \u0641\u064a \u0627\u0644\u062f\u0645"},"content":{"rendered":"<section data-role=\"list\">\n<section>\n<section>\u9488\u5bf9\u201c<strong>\u5e72\u7ec6\u80de\u6cbb\u7597\u80fd\u6539\u5584\u5e15\u91d1\u68ee\u60a3\u8005\u7684\u80be\u529f\u80fd\u5417<\/strong>\u201d\u8fd9\u4e00\u5173\u952e\u95ee\u9898\uff0c\u4e00\u9879\u6700\u65b0\u7684\u4e34\u5e8a\u7814\u7a76\u7ed9\u51fa\u4e86\u4ee4\u4eba\u632f\u594b\u7684\u7ebf\u7d22\u3002\u4f20\u7edf\u4e0a\uff0c\u5e15\u91d1\u68ee\u75c5\u4e0e\u80be\u529f\u80fd\u8870\u9000\u5e38\u88ab\u89c6\u4e3a\u4e24\u79cd\u72ec\u7acb\u7684\u5e74\u9f84\u76f8\u5173\u75be\u75c5\uff0c\u4f46\u8fd1\u5e74\u7814\u7a76\u53d1\u73b0\uff0c\u5b83\u4eec\u901a\u8fc7\u201c\u80be-\u8111\u8f74\u201d\u76f8\u4e92\u52a0\u5267\uff0c\u5f62\u6210\u6076\u6027\u5faa\u73af\u3002<\/section>\n<section><\/section>\n<section>\u5728\u8fd9\u4e00\u80cc\u666f\u4e0b\uff0c\u518d\u751f\u533b\u5b66\u9886\u57df\u4f20\u6765\u4e86\u7a81\u7834\u6027\u6d88\u606f\uff1a\u4e00\u9879\u53d1\u8868\u4e8e\u300aStem Cell Research &amp; Therapy\u300b\u7684\u4e8c\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5728\u8bc4\u4f30\u5e72\u7ec6\u80de\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\u5b89\u5168\u6027\u7684\u8fc7\u7a0b\u4e2d\uff0c\u610f\u5916\u53d1\u73b0\u5176\u5bf9\u60a3\u8005\u7684\u80be\u529f\u80fd\u4ea7\u751f\u4e86<strong>\u663e\u8457\u4e14\u5448\u5242\u91cf\u4f9d\u8d56\u6027\u7684\u6539\u5584<\/strong>\u3002\u8fd9\u4e00\u53d1\u73b0\u4e0d\u4ec5\u4e3a\u9884\u9632\u548c\u7ba1\u7406<a href=\"https:\/\/www.hjtdsm.cn\/ar\/research\/ns\/19641.html\/\" target=\"_blank\" 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srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/istockphoto-1026273002-612x612-1.jpg 612w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/istockphoto-1026273002-612x612-1-300x169.jpg 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/istockphoto-1026273002-612x612-1-18x10.jpg 18w\" sizes=\"(max-width: 612px) 100vw, 612px\" \/> \u00a0 \u00a0\u00a0<\/section>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_79_2 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: 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id=\"%E4%B8%80%E3%80%81_%E4%B8%8D%E5%8F%AF%E5%BF%BD%E8%A7%86%E7%9A%84%E5%85%B3%E8%81%94%EF%BC%9A%E8%A1%B0%E8%80%81%E3%80%81%E5%B8%95%E9%87%91%E6%A3%AE%E4%B8%8E%E8%82%BE%E5%8A%9F%E8%83%BD%E8%A1%B0%E9%80%80%E7%9A%84%E6%81%B6%E6%80%A7%E5%BE%AA%E7%8E%AF\"><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e00\u3001 \u4e0d\u53ef\u5ffd\u89c6\u7684\u5173\u8054\uff1a\u8870\u8001\u3001\u5e15\u91d1\u68ee\u4e0e\u80be\u529f\u80fd\u8870\u9000\u7684\u6076\u6027\u5faa\u73af<\/span><\/span><\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<\/section>\n<\/section>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4eba\u53e3\u8001\u9f84\u5316\u6b63\u5bfc\u81f4\u5e15\u91d1\u68ee\u75c5\uff08PD\uff09\u4e0e\u6162\u6027\u80be\u75c5\uff08<\/span><\/span><span class=\"\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">CKD<\/span><\/span><\/span><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff09\u8fd9\u4e24\u79cd\u4e0e\u5e74\u9f84\u5bc6\u5207\u76f8\u5173\u75be\u75c5\u60a3\u75c5\u7387\u7684\u663e\u7740\u4e0a\u5347\u3002\u66f4\u4e3a\u68d8\u624b\u7684\u662f\uff0c\u7814\u7a76\u8868\u660e\u4e8c\u8005\u5e76\u975e\u5b64\u7acb\u5b58\u5728\uff0c\u800c\u662f\u901a\u8fc7\u201c\u80be-\u8111\u8f74\u201d\u9677\u5165\u6076\u6027\u5faa\u73af\uff1a\u4e00\u65b9\u9762\uff0c\u80be\u810f\u529f\u80fd\u53d7\u635f\u540e\u6e05\u9664\u4f53\u5185\u6709\u5bb3\u86cb\u767d\u8d28\uff08\u5982\u03b1-\u7a81\u89e6\u6838\u86cb\u767d\uff09\u7684\u80fd\u529b\u4e0b\u964d\uff0c\u53ef\u80fd\u52a0\u5267\u5e15\u91d1\u68ee\u75c5\u7684\u75c5\u7406\u8fdb\u7a0b\uff1b\u53e6\u4e00\u65b9\u9762\uff0c\u5e15\u91d1\u68ee\u75c5\u5f15\u53d1\u7684\u81ea\u4e3b\u795e\u7ecf\u529f\u80fd\u969c\u788d\uff08\u5982\u76f4\u7acb\u6027\u4f4e\u8840\u538b\uff09\u4f1a\u635f\u5bb3\u80be\u810f\u8840\u6d41\u704c\u6ce8\uff0c\u4ece\u800c\u52a0\u901f\u80be\u635f\u4f24\u3002<\/span><\/span><\/p>\n<section><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-19710\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/istockphoto-1477427988-612x612-1.jpg\" alt=\"\" width=\"612\" height=\"344\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/istockphoto-1477427988-612x612-1.jpg 612w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/istockphoto-1477427988-612x612-1-300x169.jpg 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/istockphoto-1477427988-612x612-1-18x10.jpg 18w\" sizes=\"(max-width: 612px) 100vw, 612px\" \/><\/section>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u9664\u6b64\u4e4b\u5916\uff0c\u8870\u8001\u8fc7\u7a0b\u672c\u8eab\u5373\u662f\u80be\u529f\u80fd\u4e0b\u964d\u7684\u6838\u5fc3\u9a71\u52a8\u56e0\u7d20\u3002\u968f\u7740\u5e74\u9f84\u589e\u957f\uff0c\u80be\u810f\u4f1a\u7ecf\u5386\u7ec6\u80de\u8870\u8001\u3001\u6162\u6027\u708e\u75c7\u7b49\u4e00\u7cfb\u5217\u590d\u6742\u7684\u9000\u884c\u6027\u53d8\u5316\uff0c\u5bfc\u81f4\u8bb8\u591a\u8001\u5e74\u4eba\u5373\u4f7f\u6ca1\u6709\u4f20\u7edf\u80be\u75c5\uff0c\u5176\u80be\u529f\u80fd\u4e5f\u4f1a\u81ea\u7136\u8870\u9000\u81f3CKD\u8bca\u65ad\u6807\u51c6\u3002\u9762\u5bf9\u8fd9\u4e00\u4e25\u5cfb\u6311\u6218\uff0c\u73b0\u6709\u7684\u6cbb\u7597\u65b9\u6cd5\u96be\u4ee5\u6709\u6548\u963b\u6b62\u6216\u9006\u8f6c\u4e0e\u5e74\u9f84\u76f8\u5173\u7684\u80be\u529f\u80fd\u8870\u9000\uff0c\u5de8\u5927\u7684\u4e34\u5e8a\u9700\u6c42\u4e9f\u5f85\u6ee1\u8db3\u3002<\/span><\/span><\/p>\n<p>\u5728\u8fd9\u4e00\u80cc\u666f\u4e0b\uff0c\u518d\u751f\u533b\u5b66\u7684\u4ee3\u8868\u2014\u2014\u5e72\u7ec6\u80de\u7597\u6cd5\uff0c\u88ab\u89c6\u4e3a\u4e00\u4e2a\u6709\u6f5c\u529b\u7684\u65b0\u65b9\u5411\u3002\u8fd1\u65e5\uff0c\u53d1\u8868\u4e8e\u56fd\u9645\u671f\u520a\u300aStem Cell Research&amp;Therapy\u300b\u7684\u4e00\u9879\u4e8c\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08NCT04506073\uff09\u5e26\u6765\u4e86\u4ee4\u4eba\u632f\u594b\u7684\u65b0\u8bc1\u636e<a href=\"https:\/\/stemcellres.biomedcentral.com\/articles\/10.1186\/s13287-025-04577-y\" target=\"_blank\" rel=\"noopener nofollow\">[1]<\/a>\u3002<\/p>\n<section><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-19716 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/wechat_2025-10-13_141036_569-1.png\" alt=\"\u540c\u79cd\u5f02\u4f53\u9aa8\u9ad3\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u5728\u8001\u5316\u80be\u810f\u4e2d\u7684\u5e94\u7528\uff1a\u5e15\u91d1\u68ee\u75c5\u4e34\u5e8a\u8bd5\u9a8c\u7684\u6b21\u8981\u7ed3\u679c\" width=\"767\" height=\"452\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/wechat_2025-10-13_141036_569-1.png 767w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/wechat_2025-10-13_141036_569-1-300x177.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/wechat_2025-10-13_141036_569-1-18x12.png 18w\" sizes=\"(max-width: 767px) 100vw, 767px\" \/><\/section>\n<p>\u8be5\u7814\u7a76\u672c\u65e8\u5728\u8bc4\u4f30\u540c\u79cd\u5f02\u4f53\u9aa8\u9ad3\u6e90\u6027\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08allo-hMSCs\uff09\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\u7684\u5b89\u5168\u6027\uff0c\u5374\u5728\u6b21\u8981\u7ec8\u70b9\u2014\u2014\u8001\u5e74\u60a3\u8005\u80be\u529f\u80fd\u6307\u6807\u4e0a\uff0c\u53d1\u73b0\u4e86\u663e\u8457\u4e14\u5177\u6709\u5242\u91cf\u4f9d\u8d56\u6027\u7684\u6539\u5584\u3002\u8fd9\u63d0\u793a\u6211\u4eec\uff0c\u5e72\u7ec6\u80de\u6cbb\u7597\u6216\u8bb8\u80fd\u540c\u65f6\u9776\u5411&#8221;\u80be-\u8111\u8f74&#8221;\u7684\u4e24\u7aef\uff0c\u4e3a\u6253\u7834\u8fd9\u4e00\u6076\u6027\u5faa\u73af\u63d0\u4f9b\u4e86\u5168\u65b0\u7684\u89e3\u51b3\u65b9\u6848\u3002<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%E4%BA%8C%E3%80%81_%E4%B8%A5%E8%B0%A8%E8%AE%BE%E8%AE%A1%EF%BC%9A%E4%B8%80%E9%A1%B9%E9%92%88%E5%AF%B9%E8%80%81%E5%B9%B4%E5%B8%95%E9%87%91%E6%A3%AE%E6%82%A3%E8%80%85%E7%9A%84%E9%9A%8F%E6%9C%BA%E5%8F%8C%E7%9B%B2%E8%AF%95%E9%AA%8C\"><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e8c\u3001 \u4e25\u8c28\u8bbe\u8ba1\uff1a\u4e00\u9879\u9488\u5bf9\u8001\u5e74\u5e15\u91d1\u68ee\u60a3\u8005\u7684\u968f\u673a\u53cc\u76f2\u8bd5\u9a8c<\/span><\/span><\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u672c\u7814\u7a76\u4e8e2020\u5e7411\u6708\u81f32023\u5e747\u6708\u5728\u7f8e\u56fd\u5fb7\u514b\u8428\u65af\u5927\u5b66\u4f11\u65af\u987f\u5065\u5eb7\u79d1\u5b66\u4e2d\u5fc3\u8fdb\u884c\uff0c\u662f\u4e00\u9879\u5355\u4e2d\u5fc3\u3001II\u671f\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u4e34\u5e8a\u8bd5\u9a8c\u3002\u7814\u7a76\u65e8\u5728\u5206\u6790\u5e15\u91d1\u68ee\u75c5\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u540c\u79cd\u5f02\u4f53\u9aa8\u9ad3\u6e90\u6027\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u5bf9\u53c2\u4e0e\u8005\u80be\u810f\u7684\u6f5c\u5728\u5f71\u54cd(NCT04506073)\u3002<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7814\u7a76\u5bf9\u8c61\uff1a\u5171\u62db\u52df\u4e8645\u540d50\u81f379\u5c81\u7684\u8f7b\u5ea6\u81f3\u4e2d\u5ea6\u5e15\u91d1\u68ee\u75c5\u60a3\u8005\u3002\u4e3a\u786e\u4fdd\u6e05\u6670\u89c2\u5bdf\u5e72\u7ec6\u80de\u5bf9\u8870\u8001\u80be\u810f\u672c\u8eab\u7684\u5f71\u54cd\uff0c\u7814\u7a76\u8bbe\u5b9a\u4e86\u4e00\u4e2a\u5173\u952e\u6392\u9664\u6807\u51c6\uff1a\u57fa\u7ebf\u4f30\u7b97\u80be\u5c0f\u7403\u6ee4\u8fc7\u7387\uff08eGFR\uff09\u4f4e\u4e8e45mL\/min\/1.73m\u00b2\u3002\u6700\u7ec8\uff0c\u670940\u540d\u60a3\u8005\u5b8c\u6210\u4e86\u957f\u8fbe88\u5468\u7684\u5168\u7a0b\u968f\u8bbf\uff0c\u663e\u793a\u4e86\u6781\u9ad8\u7684\u7814\u7a76\u5b8c\u6210\u7387\u3002<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u57fa\u7ebf\u7279\u5f81\uff1a\u7814\u7a76\u961f\u5217\u5e73\u5747\u5e74\u9f8466.5\u5c81\uff0c\u57fa\u7ebf\u5e73\u5747eGFR\u4e3a81.12mL\/min\/1.73m\u00b2\uff0c\u5904\u4e8e\u5e74\u9f84\u76f8\u5173\u7684\u6b63\u5e38\u8303\u56f4\uff0c\u4e14\u5404\u7ec4\u95f4\u53ef\u80fd\u5f71\u54cd\u80be\u529f\u80fd\u7684\u836f\u7269\u4f7f\u7528\u60c5\u51b5\u5747\u8861\uff0c\u4e3a\u7ed3\u679c\u7684\u53ef\u6bd4\u6027\u5960\u5b9a\u4e86\u53ef\u9760\u57fa\u7840\uff08\u88681\uff09\u3002<\/span><\/span><\/p>\n<section><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-19715\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/wechat_2025-10-13_141152_297.png\" alt=\"\" width=\"1254\" height=\"843\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/wechat_2025-10-13_141152_297.png 1254w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/wechat_2025-10-13_141152_297-300x202.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/wechat_2025-10-13_141152_297-1024x688.png 1024w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/wechat_2025-10-13_141152_297-768x516.png 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/wechat_2025-10-13_141152_297-18x12.png 18w\" sizes=\"(max-width: 1254px) 100vw, 1254px\" \/><\/section>\n<p><b data-test=\"table-caption\" data-pm-slice=\"0 0 []\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u88681\uff1a\u53c2\u4e0e\u8005\u7684\u57fa\u7ebf\u7279\u5f81<\/span><\/span><\/span><\/b><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6cbb\u7597\u65b9\u6cd5\uff1a\u60a3\u8005\u88ab\u968f\u673a\u5206\u4e3a\u4e09\u7ec4\uff0c\u5206\u522b\u63a5\u53d7\u4e09\u79cd\u4e0d\u540c\u7684\u8f93\u6ce8\u65b9\u6848\uff1aa) \u4e09\u6b21\u5e72\u7ec6\u80de\u8f93\u6ce8\uff1bb) \u4e24\u6b21\u5e72\u7ec6\u80de\u8f93\u6ce8+\u4e00\u6b21\u5b89\u6170\u5242\uff1bc) \u4e09\u6b21\u5b89\u6170\u5242\u3002\u5e72\u7ec6\u80de\u6765\u6e90\u4e8e\u5355\u4e00\u5065\u5eb7\u4f9b\u4f53\uff0c\u5e76\u5728\u4e25\u683c\u7684\u8d28\u91cf\u63a7\u5236\u4e0b\u5236\u5907\uff0c\u786e\u4fdd\u4e86\u6cbb\u7597\u7684\u4e00\u81f4\u6027\u4e0e\u5b89\u5168\u6027\u3002<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8bc4\u4f30\u6307\u6807\uff1a\u4e3a\u4e86\u8bc4\u4f30\u5bf9\u80be\u810f\u7684\u5f71\u54cd\uff0c\u901a\u8fc7\u57fa\u7ebf\u3001\u524d\u4e24\u6b21\u8f93\u6ce8\u540e9\u5468\u4ee5\u53ca\u7b2c40\u5468\u548c\u7b2c88\u5468\u7684eGFR\u3001\u8840\u6e05\u808c\u9150( <\/span><\/span><span class=\"\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">SCr<\/span><\/span><\/span><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> ) \u548c\u8840\u5c3f\u7d20\u6c2e(BUN) \u8bc4\u4f30\u80be\u529f\u80fd\u3002<\/span><\/span><\/p>\n<h2><span class=\"ez-toc-section\" id=\"%E4%B8%89%E3%80%81%E6%8E%A2%E8%AE%A8%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E8%83%BD%E6%94%B9%E5%96%84%E5%B8%95%E9%87%91%E6%A3%AE%E6%82%A3%E8%80%85%E7%9A%84%E8%82%BE%E5%8A%9F%E8%83%BD%E5%90%97%E7%9A%84%E4%B8%89%E5%A4%A7%E7%BB%93%E6%9E%9C\"><\/span><strong>\u4e09\u3001\u63a2\u8ba8\u5e72\u7ec6\u80de\u6cbb\u7597\u80fd\u6539\u5584\u5e15\u91d1\u68ee\u60a3\u8005\u7684\u80be\u529f\u80fd\u5417\u7684\u4e09\u5927\u7ed3\u679c<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<h3><span class=\"ez-toc-section\" id=\"%E6%94%B9%E5%96%84%E8%82%BE%E5%8A%9F%E8%83%BD%E7%9A%84%E7%BB%93%E6%9E%9C%E4%B9%8B%E4%B8%80%E8%A1%80%E6%B8%85%E8%82%8C%E9%85%90\"><\/span><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6539\u5584\u80be\u529f\u80fd\u7684\u7ed3\u679c\u4e4b\u4e00\u8840\u6e05\u808c\u9150<\/span><\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5728\u8840\u6e05\u808c\u9150\uff08SCr\uff09\u65b9\u9762\uff0c\u7814\u7a76\u7ed3\u679c\u663e\u793a\u51fa\u663e\u7740\u7684\u5242\u91cf\u4f9d\u8d56\u6027\u6539\u5584\u3002\u63a5\u53d7\u4e09\u6b21\u5e72\u7ec6\u80de\u8f93\u6ce8\u7684\u6cbb\u7597\u7ec4\u6548\u679c\u6700\u4e3a\u660e\u786e\uff0c\u5176\u4f30\u7b97\u7684\u5e73\u5747SCr\u6c34\u5e73\u5728\u7b2c40\u5468\u548c\u7b2c88\u5468\u5747\u6301\u7eed\u4f4e\u4e8e\u5b89\u6170\u5242\u7ec4\uff08\u88682\uff09\u3002\u66f4\u91cd\u8981\u7684\u662f\uff0c\u591a\u6c34\u5e73\u6a21\u578b\u5206\u6790\u663e\u793a\uff0c\u8be5\u7ec4SCr\u7684\u6bcf\u65e5\u53d8\u5316\u7387\u4e0e\u5b89\u6170\u5242\u7ec4\u5b58\u5728\u6781\u663e\u7740\u5dee\u5f02\uff08PP&gt;99.9%\uff09\u3002<\/span><\/span><\/p>\n<section><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-19714\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/wechat_2025-10-13_141327_538.png\" alt=\"\" width=\"1255\" height=\"370\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/wechat_2025-10-13_141327_538.png 1255w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/wechat_2025-10-13_141327_538-300x88.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/wechat_2025-10-13_141327_538-1024x302.png 1024w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/wechat_2025-10-13_141327_538-768x226.png 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/wechat_2025-10-13_141327_538-18x5.png 18w\" sizes=\"(max-width: 1255px) 100vw, 1255px\" \/><\/section>\n<p><b data-test=\"table-caption\" data-pm-slice=\"0 0 []\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u88682\uff1a40\u5468\u548c88\u5468\u968f\u8bbf\u65f6\u80be\u529f\u80fd\u7684\u6a2a\u65ad\u9762\u63cf\u8ff0<\/span><\/span><\/span><\/b><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5f53\u5916\u63a8\u81f3\u5e74\u5ea6\u53d8\u5316\u65f6\uff0c\u4e09\u6b21\u8f93\u6ce8\u7ec4\u7684SCr-0.033mg\/dL\/\u5e74\u7684\u901f\u5ea6\u4e0b\u964d\uff0c\u800c\u5b89\u6170\u5242\u7ec4\u5219\u4ee5+0.055mg\/dL\/\u5e74\u7684\u901f\u5ea6\u4e0a\u5347\uff0c\u8fd9\u4e00\u964d\u4e00\u5347\u5f62\u6210\u4e86\u9c9c\u660e\u5bf9\u6bd4\uff0c\u8868\u660e\u8db3\u91cf\u5e72\u7ec6\u80de\u8f93\u6ce8\u53ef\u80fd\u9006\u8f6c\u4e86\u4e0e\u5e74\u9f84\u76f8\u5173\u7684\u80be\u529f\u80fd\u51cf\u9000\u8d8b\u52bf\uff08\u56fe1\uff09\u3002<\/span><\/span><\/p>\n<section><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-19713\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/\u5fae\u4fe1\u56fe\u7247_2025-10-13_141358_585.png\" alt=\"\" width=\"1921\" height=\"763\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/\u5fae\u4fe1\u56fe\u7247_2025-10-13_141358_585.png 1921w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/\u5fae\u4fe1\u56fe\u7247_2025-10-13_141358_585-300x119.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/\u5fae\u4fe1\u56fe\u7247_2025-10-13_141358_585-1024x407.png 1024w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/\u5fae\u4fe1\u56fe\u7247_2025-10-13_141358_585-768x305.png 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/\u5fae\u4fe1\u56fe\u7247_2025-10-13_141358_585-1536x610.png 1536w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/\u5fae\u4fe1\u56fe\u7247_2025-10-13_141358_585-18x7.png 18w\" sizes=\"(max-width: 1921px) 100vw, 1921px\" \/><\/section>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u56fe1\uff1a<\/span><\/span><span data-pm-slice=\"0 0 []\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4f7f\u7528\u8d1d\u53f6\u65af\u6a21\u578b\u5206\u6790\u4f30\u8ba1\u8001\u9f84\u5316\u4eba\u7fa4\u63a5\u53d7\u9aa8\u9ad3\u95f4\u5145\u8d28\u5e72\u7ec6\u80de(allo-hMSC) \u6cbb\u7597\u540e\u8840\u6e05\u808c\u9150\u6c34\u5e73\u7684\u6bcf\u65e5\u53d8\u5316\u7387\u3002\u56feA\u663e\u793a\u4e86\u4e09\u4e2a\u6cbb\u7597\u7ec4\u8840\u6e05\u808c\u9150\u6c34\u5e73\u968f\u65f6\u95f4\u7684\u53d8\u5316\u3002\u56feB\u3001C\u548cD\u5206\u522b\u663e\u793a\u4e86\u63a5\u53d7\u4e09\u6b21\u5f02\u57fa\u56e0hMSC\u8f93\u6ce8\u3001\u4e00\u6b21\u5b89\u6170\u5242\u8f93\u6ce8\u540e\u4e24\u6b21\u5f02\u57fa\u56e0hMSC\u8f93\u6ce8\u4ee5\u53ca\u4e09\u6b21\u5b89\u6170\u5242\u8f93\u6ce8\u7684\u60a3\u8005\u8840\u6e05\u808c\u9150\u6c34\u5e73\u6bcf\u65e5\u53d8\u5316\u7387\u7684\u540e\u9a8c\u5206\u5e03\u3002<\/span><\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u4e24\u6b21\u5e72\u7ec6\u80de\u8f93\u6ce8\u5bf9\u8840\u6e05\u808c\u9150\u7684\u6539\u5584\u6548\u679c\u5219\u975e\u5e38\u6709\u9650\u4e14\u4e0d\u660e\u786e\u3002\u8be5\u7ec4\u5728\u7b2c40\u5468\u548c\u7b2c88\u5468\u4e0e\u5b89\u6170\u5242\u7ec4\u5747\u65e0\u663e\u7740\u5dee\u5f02\u3002\u5176\u5e74\u5ea6\u53d8\u5316\u7387\u4e3a+0.029mg\/dL\/\u5e74\uff0c\u867d\u7136\u4f4e\u4e8e\u5b89\u6170\u5242\u7ec4\uff0c\u4f46\u8d8b\u52bf\u65b9\u5411\u4e00\u81f4\uff08\u4ecd\u5728\u4e0a\u5347\uff09\uff0c\u8868\u660e\u4e24\u6b21\u8f93\u6ce8\u7684\u65b9\u6848\u4e0d\u8db3\u4ee5\u4ea7\u751f\u5177\u6709\u4e34\u5e8a\u610f\u4e49\u7684\u80be\u810f\u4fdd\u62a4\u4f5c\u7528\u3002<\/span><\/span><\/p>\n<h3><span class=\"ez-toc-section\" id=\"%E6%94%B9%E5%96%84%E8%82%BE%E5%8A%9F%E8%83%BD%E7%9A%84%E7%BB%93%E6%9E%9C%E4%B9%8B%E4%B8%80%E8%A1%80%E6%B8%85%E5%B0%BF%E7%B4%A0%E6%B0%AE\"><\/span><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" 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style=\"vertical-align: inherit;\">\u7efc\u5408\u6765\u770b\uff0c\u672c\u7814\u7a76\u8868\u660e\uff0c\u540c\u79cd\u5f02\u4f53\u9aa8\u9ad3\u6e90\u6027\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6cbb\u7597\u5bf9\u80be\u529f\u80fd\u7684\u5f71\u54cd\u5177\u6709\u6307\u6807\u7279\u5f02\u6027\u548c\u5242\u91cf\u4f9d\u8d56\u6027\u3002\u4e09\u6b21\u8f93\u6ce8\u7684\u8db3\u91cf\u65b9\u6848\u663e\u793a\u51fa\u660e\u786e\u7684\u6f5c\u529b\uff0c\u80fd\u663e\u7740\u6539\u5584\u8840\u6e05\u808c\u9150\u6c34\u5e73\u53ca\u5176\u957f\u671f\u53d8\u5316\u8d8b\u52bf\uff0c\u8fd9\u53ef\u80fd\u610f\u5473\u7740\u5b83\u5ef6\u7f13\u4e86\u4e0e\u5e74\u9f84\u76f8\u5173\u7684\u80be\u529f\u80fd\u8870\u9000\u3002\u7136\u800c\uff0c\u8be5\u76ca\u5904\u5e76\u672a\u5728\u8840\u6e05<\/span><\/span><span class=\"\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5c3f\u7d20\u6c2e\u6307\u6807<\/span><\/span><\/span><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e0a\u540c\u6b65\u4f53\u73b0\uff0c\u4e14\u4e24\u6b21\u8f93\u6ce8\u7684\u65b9\u6848\u6548\u679c\u4e0d\u4f73\uff0c\u8fd9\u4e3a\u672a\u6765\u4f18\u5316\u6cbb\u7597\u7b56\u7565\u4ee5\u5168\u9762\u4fdd\u62a4\u80be\u810f\u529f\u80fd\u63d0\u4f9b\u4e86\u5173\u952e\u65b9\u5411\u3002<\/span><\/span><\/p>\n<h3><span class=\"ez-toc-section\" id=\"%E6%94%B9%E5%96%84%E8%82%BE%E5%8A%9F%E8%83%BD%E7%9A%84%E7%BB%93%E6%9E%9C%E4%B9%8B%E4%B8%80%E4%BC%B0%E8%AE%A1%E8%82%BE%E5%B0%8F%E7%90%83%E6%BB%A4%E8%BF%87%E7%8E%87\"><\/span><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6539\u5584\u80be\u529f\u80fd\u7684\u7ed3\u679c\u4e4b\u4e00\u4f30\u8ba1\u80be\u5c0f\u7403\u6ee4\u8fc7\u7387<\/span><\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u9996\u5148\uff0c\u63a5\u53d7\u4e09\u6b21\u5e72\u7ec6\u80de\u8f93\u6ce8\u7684\u6cbb\u7597\u7ec4\u5728\u4f30\u7b97\u80be\u5c0f\u7403\u6ee4\u8fc7\u7387\u4e0a\u8868\u73b0\u51fa\u663e\u7740\u4e14\u6301\u7eed\u7684\u6539\u5584\u3002\u4e0e\u5b89\u6170\u5242\u7ec4\u76f8\u6bd4\uff0c\u8be5\u7ec4\u7684eGFR\u5728\u7b2c40\u5468\u65f6\u5e73\u5747\u9ad8\u51fa13.2mL\/min\/1.73m\u00b2\uff0c\u4e14\u8fd9\u4e00\u5dee\u5f02\u5177\u6709\u6781\u9ad8\u7684\u7edf\u8ba1\u5b66\u53ef\u4fe1\u5ea6\uff08\u540e\u9a8c\u6982\u7387PP=99.1%\uff09\uff1b\u5230\u7b2c88\u5468\u968f\u8bbf\u7ed3\u675f\u65f6\uff0c\u5176eGFR\u4f9d\u7136\u4fdd\u6301\u4f18\u52bf\uff0c\u5e73\u5747\u9ad8\u51fa9.4mL\/min\/1.73m\u00b2\uff08PP=93.6%\uff09\uff08\u56fe2\uff09\u3002<\/span><\/span><\/p>\n<section><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-19712\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/\u5fae\u4fe1\u56fe\u7247_2025-10-13_141416_354.png\" alt=\"\" width=\"1961\" height=\"794\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/\u5fae\u4fe1\u56fe\u7247_2025-10-13_141416_354.png 1961w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/\u5fae\u4fe1\u56fe\u7247_2025-10-13_141416_354-300x121.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/\u5fae\u4fe1\u56fe\u7247_2025-10-13_141416_354-1024x415.png 1024w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/\u5fae\u4fe1\u56fe\u7247_2025-10-13_141416_354-768x311.png 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/\u5fae\u4fe1\u56fe\u7247_2025-10-13_141416_354-1536x622.png 1536w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/\u5fae\u4fe1\u56fe\u7247_2025-10-13_141416_354-18x7.png 18w\" sizes=\"(max-width: 1961px) 100vw, 1961px\" \/><\/section>\n<p><span data-pm-slice=\"0 0 []\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u56fe2\uff1a\u4f7f\u7528\u8d1d\u53f6\u65af\u6a21\u578b\u5206\u6790\u4f30\u8ba1\u8001\u9f84\u5316\u4eba\u7fa4\u63a5\u53d7\u9aa8\u9ad3\u95f4\u5145\u8d28\u5e72\u7ec6\u80de(allo-hMSC) \u6cbb\u7597\u540e\u80be\u5c0f\u7403\u6ee4\u8fc7\u7387(eGRF) \u7684\u6bcf\u65e5\u53d8\u5316\u7387\u3002\u56feA\u663e\u793a\u4e86\u4e09\u4e2a\u6cbb\u7597\u7ec4eGFR\u968f\u65f6\u95f4\u7684\u53d8\u5316\u3002\u56feB\u3001C\u548cD\u5206\u522b\u663e\u793a\u4e86\u63a5\u53d7\u4e09\u6b21allo-hMSC\u8f93\u6ce8\u3001\u4e00\u6b21\u5b89\u6170\u5242\u540e\u4e24\u6b21allo-hMSC\u8f93\u6ce8\u4ee5\u53ca\u4e09\u6b21\u5b89\u6170\u5242\u8f93\u6ce8\u7684\u60a3\u8005\u7684eGFR\u6bcf\u65e5\u53d8\u5316\u7387\u7684\u540e\u9a8c\u5206\u5e03\u3002<\/span><\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6700\u6709\u529b\u7684\u8bc1\u636e\u6765\u81ea\u4e8e\u5bf9eGFR\u53d8\u5316\u8d8b\u52bf\u7684\u5206\u6790\uff1a\u8be5\u7ec4\u7684eGFR\u4ee5+3.29 mL\/min\/1.73m\u00b2\/\u5e74\u7684\u901f\u5ea6\u663e\u7740\u63d0\u5347\uff0c\u8fd9\u4e0e\u5b89\u6170\u5242\u7ec4eGFR\u4ee5-2.92 mL\/min\/1.73m\u00b2\/\u5e74\u7684\u901f\u5ea6\u81ea\u7136\u8870\u9000\u5f62\u6210\u4e86\u9c9c\u660e\u5bf9\u6bd4\uff0c\u8868\u660e\u8db3\u91cf\u7684\u5e72\u7ec6\u80de\u6cbb\u7597\u4e0d\u4ec5\u5ef6\u7f13\u4e86\u4e0e\u5e74\u9f84\u76f8\u5173\u7684\u80be\u529f\u80fd\u4e0b\u964d\uff0c\u751a\u81f3\u53ef\u80fd\u5728\u4e00\u5b9a\u7a0b\u5ea6\u4e0a\u9006\u8f6c\u4e86\u8fd9\u4e00\u8d8b\u52bf\u3002<\/span><\/span><\/p>\n<p><span data-pm-slice=\"0 0 []\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7136\u800c\uff0c\u6cbb\u7597\u6548\u679c\u5448\u73b0\u51fa\u4e25\u683c\u7684<\/span><\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5242\u91cf\u4f9d\u8d56\u6027<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u3002<\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e24\u6b21\u8f93\u6ce8\u7ec4<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5728eGFR\u548c\u8840\u6e05\u808c\u9150\u4e0a\u7684\u6539\u5584\u5747\u975e\u5e38\u6709\u9650\uff0c\u5176eGFR\u5e74\u4e0b\u964d\u7387\u4e3a-1.46mL\/min\/1.73m\u00b2\/\u5e74\uff0c\u867d\u6162\u4e8e\u5b89\u6170\u5242\u7ec4\uff0c\u4f46\u8d8b\u52bf\u4ecd\u672a\u626d\u8f6c\u3002\u8fd9\u6e05\u6670\u8868\u660e\uff0c<\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8db3\u7597\u7a0b\u7684\u6cbb\u7597\u662f\u4ea7\u751f\u80be\u810f\u4fdd\u62a4\u6548\u5e94\u7684\u5173\u952e<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u3002<\/span><\/span><\/p>\n<h3><span class=\"ez-toc-section\" id=\"%E6%94%B9%E5%96%84%E8%82%BE%E5%8A%9F%E8%83%BD%E7%9A%84%E7%BB%93%E6%9E%9C%E4%B9%8B%E4%B8%80%E8%9B%8B%E7%99%BD%E5%B0%BF\"><\/span><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6539\u5584\u80be\u529f\u80fd\u7684\u7ed3\u679c\u4e4b\u4e00\u86cb\u767d\u5c3f<\/span><\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u57fa\u7ebf\u65f6\uff0c\u63a5\u53d7\u4e24\u4efd\u5f02\u57fa\u56e0hMSC\u6cbb\u7597\u7684\u53d7\u8bd5\u8005\u4e2d\u6240\u6709\u53d7\u8bd5\u8005\u5747\u672a\u51fa\u73b0\u86cb\u767d\u5c3f\uff0c\u800c\u5b89\u6170\u5242\u7ec414\u4eba\u4e2d13\u4eba\uff0892.9%\uff09\u548c\u4e09\u4efd\u5f02\u57fa\u56e0hMSC\u6cbb\u7597\u768416\u4eba\u4e2d14\u4eba\uff0887.5%\uff09\u5747\u672a\u51fa\u73b0\u86cb\u767d\u5c3f\uff08\u88681)\u3002\u9664\u4e09\u4f8b\u5f02\u57fa\u56e0hMSC\u7ec41\u4f8b\u60a3\u8005\u51fa\u73b030\u6beb\u514b(+)\u86cb\u767d\u5c3f\u5916\uff0c\u6240\u6709\u9633\u6027\u75c5\u4f8b\u5747\u88ab\u5f52\u7c7b\u4e3a\u5fae\u91cf\u3002\u5230\u7b2c88\u5468\uff0c\u6240\u6709\u57fa\u7ebf\u86cb\u767d\u5c3f\u75c5\u4f8b\u5747\u5df2\u6d88\u9000\u3002<\/span><\/span><\/p>\n<h2><span class=\"ez-toc-section\" id=\"%E5%9B%9B%E3%80%81%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E5%91%88%E5%89%82%E9%87%8F%E4%BE%9D%E8%B5%96%E6%80%A7%E6%94%B9%E5%96%84%E8%80%81%E5%B9%B4%E5%B8%95%E9%87%91%E6%A3%AE%E6%82%A3%E8%80%85%E8%82%BE%E5%8A%9F%E8%83%BD\"><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u56db\u3001\u5e72\u7ec6\u80de\u6cbb\u7597\u5448\u5242\u91cf\u4f9d\u8d56\u6027\u6539\u5584\u8001\u5e74\u5e15\u91d1\u68ee\u60a3\u8005\u80be\u529f\u80fd<\/span><\/span><\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8fd9\u9879\u7814\u7a76\u7684\u7ed3\u679c\u8868\u660e\uff0c\u540c\u79cd\u5f02\u4f53\u4eba\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6cbb\u7597\u5bf9\u8001\u5e74\u5e15\u91d1\u68ee\u75c5\u60a3\u8005\u7684\u80be\u529f\u80fd\uff0c\u7279\u522b\u662f\u4f30\u7b97\u80be\u5c0f\u7403\u6ee4\u8fc7\u7387\uff0c\u4ea7\u751f\u4e86\u5177\u6709\u5242\u91cf\u4f9d\u8d56\u6027\u7684\u79ef\u6781\u5f71\u54cd\u3002<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e0e\u5b89\u6170\u5242\u7ec4eGFR\u4ee5\u6bcf\u5e74-2.92mL\/min\/1.73m\u00b2\u7684\u901f\u5ea6\u663e\u7740\u6076\u5316\u76f8\u6bd4\uff0c\u63a5\u53d7\u4e09\u6b21\u5e72\u7ec6\u80de\u8f93\u6ce8\u7684\u6cbb\u7597\u7ec4\u663e\u793a\u51fa\u4ee4\u4eba\u9f13\u821e\u7684\u6539\u5584\uff0c\u5176eGFR\u4ee5\u6bcf\u5e74+3.29mL\/min\/1.73m\u00b2\u7684\u901f\u5ea6\u63d0\u5347\u3002\u8fd9\u4e00\u6b63\u4e00\u8d1f\u7684\u9c9c\u660e\u5bf9\u6bd4\uff0c\u5f3a\u70c8\u63d0\u793a\u8db3\u91cf\u7684\u5e72\u7ec6\u80de\u6cbb\u7597\u4e0d\u4ec5\u53ef\u80fd\u7a33\u5b9a\uff0c\u751a\u81f3\u6709\u671b\u9006\u8f6c\u4e0e\u5e74\u9f84\u76f8\u5173\u7684\u80be\u529f\u80fd\u81ea\u7136\u8870\u9000\u8d8b\u52bf\u3002<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8fd9\u4e9beGFR\u7684\u79ef\u6781\u53d8\u5316\u5f97\u5230\u4e86\u8840\u6e05\u808c\u9150\u6307\u6807\u7684\u6709\u529b\u652f\u6301\uff1a\u4e09\u6b21\u8f93\u6ce8\u7ec4\u7684\u808c\u9150\u6c34\u5e73\u5e74\u53d8\u5316\u7387\u4ec5\u4e3a\u8f7b\u5fae\u4e0b\u964d\uff0c\u8fdc\u4f18\u4e8e\u5b89\u6170\u5242\u7ec4\u7684\u5927\u5e45\u4e0a\u5347\u3002\u540c\u65f6\uff0c\u6240\u6709\u7ec4\u522b\u7684\u8840\u6e05\u5c3f\u7d20\u6c2e\u6c34\u5e73\u4fdd\u6301\u7a33\u5b9a\uff0c\u6392\u9664\u4e86\u6c34\u5408\u72b6\u6001\u7b49\u56e0\u7d20\u7684\u5e72\u6270\uff0c\u8fdb\u4e00\u6b65\u589e\u5f3a\u4e86eGFR\u548c<\/span><\/span><span class=\"\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u808c\u9150\u7ed3\u679c<\/span><\/span><\/span><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7684\u53ef\u4fe1\u5ea6\u3002<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5c3d\u7ba1\u672c\u7814\u7a76\u5b58\u5728\u672a\u68c0\u6d4b\u80f1\u6291\u7d20C\u7b49\u5c40\u9650\u6027\uff0c\u4f46\u73b0\u6709\u8bc1\u636e\u5df2\u4e3a\u5e72\u7ec6\u80de\u5728\u5ef6\u7f13\u80be\u810f\u8870\u8001\u65b9\u9762\u7684\u6f5c\u5728\u4e34\u5e8a\u5e94\u7528\u63d0\u4f9b\u4e86\u6709\u4ef7\u503c\u7684\u524d\u77bb\u6027\u7ebf\u7d22\u3002<\/span><\/span><\/p>\n<h2><span class=\"ez-toc-section\" id=\"%E4%BA%94%E3%80%81%E7%BB%93%E8%AE%BA%E4%B8%8E%E5%B1%95%E6%9C%9B%EF%BC%9A%E8%BF%88%E5%90%91%E8%82%BE%E8%84%91%E5%85%B1%E6%B2%BB%E7%9A%84%E6%96%B0%E8%B5%B7%E7%82%B9\"><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e94\u3001\u7ed3\u8bba\u4e0e\u5c55\u671b\uff1a\u8fc8\u5411\u80be\u8111\u5171\u6cbb\u7684\u65b0\u8d77\u70b9<\/span><\/span><\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8fd9\u9879\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0c\u5bf9\u4e8e\u80be\u529f\u80fd\u5c1a\u5b58\u7684\u8001\u5e74\u5e15\u91d1\u68ee\u75c5\u60a3\u8005\uff0c\u4ee5\u8db3\u91cf\uff0810\u00d710\u2076\u7ec6\u80de\/kg\uff09\u3001\u8db3\u7597\u7a0b\uff08\u4e09\u6b21\uff09\u7684\u65b9\u6848\u91cd\u590d\u9759\u8109\u8f93\u6ce8\u540c\u79cd\u5f02\u4f53\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff0c\u53ef\u4ee5\u5b89\u5168\u4e14\u6709\u6548\u5730\u6539\u5584\u5176\u80be\u529f\u80fd\uff0c\u5c24\u5176\u4f53\u73b0\u5728eGFR\u7684\u63d0\u5347\u548c\u8840\u6e05\u808c\u9150\u7684\u4e0b\u964d\u4e0a\u3002<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8fd9\u6807\u5fd7\u7740\u6211\u4eec\u8fc8\u51fa\u4e86\u91cd\u8981\u7684\u7b2c\u4e00\u6b65\uff0c\u9996\u6b21\u5728\u4e25\u8c28\u7684\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u9a8c\u8bc1\u4e86\u5e72\u7ec6\u80de\u4f5c\u4e3a\u6f5c\u5728\u7597\u6cd5\uff0c\u5bf9\u4e8e\u7a33\u5b9a\u751a\u81f3\u6539\u5584\u8001\u5e74\u5e15\u91d1\u68ee\u60a3\u8005\u80be\u529f\u80fd\u7684\u6982\u5ff5\u6709\u6548\u6027\u3002\u5b83\u4e0d\u4ec5\u4e3a\u9884\u9632\u548c\u7ba1\u7406\u5e15\u91d1\u68ee\u75c5\u60a3\u8005\u7684\u80be\u635f\u4f24\u63d0\u4f9b\u4e86\u65b0\u7b56\u7565\uff0c\u66f4\u91cd\u8981\u7684\u662f\uff0c\u5b83\u7a81\u7834\u4e86\u201c\u80be-\u8111\u8f74\u201d\u5173\u8054\u7684\u4e34\u5e8a\u56f0\u5883\uff0c\u4e3a\u5f00\u53d1\u80fd\u540c\u65f6\u9488\u5bf9\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u548c\u5176\u5168\u8eab\u6027\u5171\u75c5\u7684\u201c\u4e00\u4f53\u5316\u201d\u7597\u6cd5\u70b9\u71c3\u4e86\u5e0c\u671b\u3002<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u672a\u6765\u7684\u7814\u7a76\u5e94\u7eb3\u5165\u66f4\u5e7f\u6cdb\u7684\u4eba\u7fa4\uff0c\u5e76\u6df1\u5165\u5f00\u5c55\u673a\u5236\u63a2\u7d22\uff0c\u4ee5\u66f4\u597d\u5730\u8868\u5f81\u5e72\u7ec6\u80de\u7684\u6d3b\u6027\u6210\u5206\uff0c\u63ed\u793a\u5176\u9a71\u52a8\u80be\u810f\u76ca\u5904\u7684\u751f\u7269\u5b66\u901a\u8def\uff0c\u6700\u7ec8\u5c06\u8fd9\u4e00\u524d\u6cbf\u79d1\u5b66\u8f6c\u5316\u4e3a\u60e0\u53ca\u5e7f\u5927\u60a3\u8005\u7684\u4e34\u5e8a\u73b0\u5b9e\u3002<\/span><\/span><\/p>\n<section>\n<section>\n<section>\n<blockquote><p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u53c2\u8003\u8d44\u6599\uff1a<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">[1]: <\/span><\/span><span data-pm-slice=\"0 0 []\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">Martinez-Lemus, JD, Molony, DA, Suescun, J.\u00a0<\/span><\/span><\/span><i><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7b49\u3002<\/span><\/span><\/i><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u00a0\u540c\u79cd\u5f02\u4f53\u9aa8\u9ad3\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u5728\u8870\u8001\u80be\u810f\u4e2d\u7684\u5e94\u7528\uff1a\u5e15\u91d1\u68ee\u75c5\u4e34\u5e8a\u8bd5\u9a8c\u7684\u6b21\u8981\u7ed3\u679c\u3002\u300a\u00a0<\/span><\/span><i><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5e72\u7ec6\u80de\u7814\u7a76\u4e0e\u6cbb\u7597\u300b<\/span><\/span><\/i>\u00a0<b><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">16<\/span><\/span><\/b><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> , 493 (2025)\u3002https:\/\/doi.org\/10.1186\/s13287-025-04577-y<\/span><\/span><\/p><\/blockquote>\n<section>\n<blockquote><p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u514d\u8d23\u8bf4\u660e\uff1a\u672c\u6587\u4ec5\u7528\u4e8e\u4f20\u64ad\u79d1\u666e\u77e5\u8bc6\uff0c\u5206\u4eab\u884c\u4e1a\u89c2\u70b9\uff0c\u4e0d\u6784\u6210\u4efb\u4f55\u4e34\u5e8a\u8bca\u65ad\u5efa\u8bae\uff01\u676d\u5409\u5e72\u7ec6\u80de\u6240\u53d1\u5e03\u7684\u4fe1\u606f\u4e0d\u80fd\u66ff\u4ee3\u533b\u751f\u6216\u836f\u5242\u5e08\u7684\u4e13\u4e1a\u5efa\u8bae\u3002\u5982\u6709\u7248\u6743\u7b49\u7591\u95ee\uff0c\u8bf7\u968f\u65f6\u8054\u7cfb\u6211\u3002<\/span><\/span><\/p><\/blockquote>\n<style id=\"wpforms-css-vars-18859\">\n\t\t\t\t#wpforms-18859 {\n\t\t\t\t--wpforms-field-size-input-height: 43px;\n--wpforms-field-size-input-spacing: 15px;\n--wpforms-field-size-font-size: 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