{"id":19746,"date":"2025-10-17T16:19:58","date_gmt":"2025-10-17T08:19:58","guid":{"rendered":"https:\/\/www.hjtdsm.cn\/?p=19746"},"modified":"2025-10-17T16:20:34","modified_gmt":"2025-10-17T08:20:34","slug":"%e5%b8%95%e9%87%91%e6%a3%ae%e7%97%85%e7%9a%84%e5%8f%91%e7%97%85%e6%9c%ba%e5%88%b6%ef%bc%9a%e6%8f%ad%e5%bc%80%e7%a5%9e%e7%bb%8f%e9%80%80%e8%a1%8c%e6%80%a7%e7%96%be%e7%97%85%e7%9a%84%e9%bb%91","status":"publish","type":"post","link":"https:\/\/www.hjtdsm.cn\/ar\/research\/ns\/pd\/19746.html","title":{"rendered":"\u0627\u0644\u062a\u0633\u0628\u0628 \u0641\u064a \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0645\u0631\u0636 \u0628\u0627\u0631\u0643\u0646\u0633\u0648\u0646: \u0643\u0634\u0641 \"\u0627\u0644\u0635\u0646\u062f\u0648\u0642 \u0627\u0644\u0623\u0633\u0648\u062f\" \u0644\u0644\u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0639\u0635\u0628\u064a\u0629 \u0627\u0644\u062a\u0646\u0643\u0633\u064a\u0629 \u0627\u0644\u0639\u0635\u0628\u064a\u0629"},"content":{"rendered":"<p data-start=\"136\" data-end=\"239\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5e15\u91d1\u68ee<\/span><\/span><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u75c5\uff08Parkinson&#8217;s Disease\uff0cPD\uff09\u662f\u4e00\u79cd\u5e38\u89c1\u7684<\/span><\/span><strong data-start=\"170\" data-end=\"181\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff0c\u5728\u5168\u7403\u7ea6\u6709\u8d85\u8fc71000\u4e07\u4eba\u53d7\u5230\u5b83\u7684\u5f71\u54cd\u3002\u5b83\u4e0d\u4ec5\u4ec5\u662f\u201c\u624b\u6296\u201d\u7684\u75be\u75c5\uff0c\u66f4\u662f\u4e00\u573a\u6084\u7136\u53d1\u751f\u5728\u5927\u8111\u6df1\u5904\u7684\u201c\u591a\u5df4\u80fa\u5371\u673a\u201d <\/span><\/span><a href=\"https:\/\/www.frontiersin.org\/journals\/neuroscience\/articles\/10.3389\/fnins.2024.1210447\/full\" target=\"_blank\" rel=\"noopener nofollow\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">[1]<\/span><\/span><\/a><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u3002<\/span><\/span><\/p>\n<p data-start=\"241\" data-end=\"313\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u90a3\u4e48\uff0c<\/span><\/span><strong data-start=\"244\" data-end=\"257\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5e15\u91d1\u68ee\u75c5\u7684\u53d1\u75c5\u673a\u5236<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7a76\u7adf\u662f\u4ec0\u4e48\uff1f\u4e3a\u4ec0\u4e48\u4f1a\u5bfc\u81f4\u8eab\u4f53\u50f5\u786c\u3001\u52a8\u4f5c\u8fdf\u7f13\u751a\u81f3\u8ba4\u77e5\u969c\u788d\uff1f\u4eca\u5929\uff0c\u6211\u4eec\u7528\u901a\u4fd7\u6613\u61c2\u7684\u65b9\u5f0f\uff0c\u5e26\u4f60\u6df1\u5165\u4e86\u89e3\u8fd9\u4e00\u75be\u75c5\u7684\u672c\u8d28\u3002<\/span><\/span><\/p>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_79_2 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewbox=\"0 0 24 24\" version=\"1.2\" baseprofile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.hjtdsm.cn\/ar\/research\/ns\/pd\/19746.html\/#%E4%B8%80%E3%80%81%E5%B8%95%E9%87%91%E6%A3%AE%E7%97%85%EF%BC%9A%E4%BB%8E%E2%80%9C%E6%89%8B%E6%8A%96%E2%80%9D%E5%BC%80%E5%A7%8B%E7%9A%84%E5%A4%A7%E8%84%91%E5%8D%B1%E6%9C%BA\" >\u4e00\u3001\u5e15\u91d1\u68ee\u75c5\uff1a\u4ece\u201c\u624b\u6296\u201d\u5f00\u59cb\u7684\u5927\u8111\u5371\u673a<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.hjtdsm.cn\/ar\/research\/ns\/pd\/19746.html\/#%E4%BA%8C%E3%80%81%E6%A0%B8%E5%BF%83%E7%97%85%E7%90%86%E6%94%B9%E5%8F%98%EF%BC%9A%E5%A4%9A%E5%B7%B4%E8%83%BA%E8%83%BD%E7%A5%9E%E7%BB%8F%E5%85%83%E6%8D%9F%E4%BC%A4\" >\u4e8c\u3001\u6838\u5fc3\u75c5\u7406\u6539\u53d8\uff1a\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u635f\u4f24<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.hjtdsm.cn\/ar\/research\/ns\/pd\/19746.html\/#%E5%B8%95%E9%87%91%E6%A3%AE%E7%97%85%E7%9A%84%E5%8F%91%E7%97%85%E6%9C%BA%E5%88%B6\" >\u5e15\u91d1\u68ee\u75c5\u7684\u53d1\u75c5\u673a\u5236<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/www.hjtdsm.cn\/ar\/research\/ns\/pd\/19746.html\/#1%E5%A7%8B%E5%8A%A8%E7%8E%AF%E8%8A%82%EF%BC%9A%E5%B8%95%E9%87%91%E6%A3%AE%E7%97%85%E7%9A%84%E5%8F%91%E7%97%85%E6%9C%BA%E5%88%B6%E4%B9%8B%E4%B8%80%CE%B1-%E7%AA%81%E8%A7%A6%E6%A0%B8%E8%9B%8B%E7%99%BD%E5%BC%82%E5%B8%B8%E8%81%9A%E9%9B%86\" >1.\u59cb\u52a8\u73af\u8282\uff1a\u5e15\u91d1\u68ee\u75c5\u7684\u53d1\u75c5\u673a\u5236\u4e4b\u4e00\u03b1-\u7a81\u89e6\u6838\u86cb\u767d\u5f02\u5e38\u805a\u96c6<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/www.hjtdsm.cn\/ar\/research\/ns\/pd\/19746.html\/#2_%E5%8A%A0%E9%80%9F%E5%99%A8%EF%BC%9A%E7%A5%9E%E7%BB%8F%E7%82%8E%E7%97%87%E7%9A%84%E6%81%B6%E6%80%A7%E5%BE%AA%E7%8E%AF\" >2. \u52a0\u901f\u5668\uff1a\u795e\u7ecf\u708e\u75c7\u7684\u6076\u6027\u5faa\u73af<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/www.hjtdsm.cn\/ar\/research\/ns\/pd\/19746.html\/#3_%E8%83%BD%E9%87%8F%E5%8D%B1%E6%9C%BA%E4%B8%8E%E6%AF%92%E6%80%A7%E7%8E%AF%E5%A2%83%EF%BC%9A%E7%BA%BF%E7%B2%92%E4%BD%93%E5%8A%9F%E8%83%BD%E9%9A%9C%E7%A2%8D%E4%B8%8E%E6%B0%A7%E5%8C%96%E5%BA%94%E6%BF%80\" >3. \u80fd\u91cf\u5371\u673a\u4e0e\u6bd2\u6027\u73af\u5883\uff1a\u7ebf\u7c92\u4f53\u529f\u80fd\u969c\u788d\u4e0e\u6c27\u5316\u5e94\u6fc0<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/www.hjtdsm.cn\/ar\/research\/ns\/pd\/19746.html\/#%E6%B0%A7%E5%8C%96%E5%BA%94%E6%BF%80\" >\u6c27\u5316\u5e94\u6fc0<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/www.hjtdsm.cn\/ar\/research\/ns\/pd\/19746.html\/#%E7%BA%BF%E7%B2%92%E4%BD%93%E5%8A%9F%E8%83%BD%E9%9A%9C%E7%A2%8D\" >\u7ebf\u7c92\u4f53\u529f\u80fd\u969c\u788d<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/www.hjtdsm.cn\/ar\/research\/ns\/pd\/19746.html\/#4_%E9%81%97%E4%BC%A0%E4%B8%8E%E7%8E%AF%E5%A2%83%E5%9B%A0%E7%B4%A0%E7%9A%84%E4%BA%A4%E4%BA%92\" >4. \u9057\u4f20\u4e0e\u73af\u5883\u56e0\u7d20\u7684\u4ea4\u4e92<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/www.hjtdsm.cn\/ar\/research\/ns\/pd\/19746.html\/#%E5%B8%95%E9%87%91%E6%A3%AE%E7%97%85%E7%9A%84%E5%8F%91%E7%97%85%E6%9C%BA%E5%88%B6%E5%91%8A%E8%AF%89%E6%88%91%E4%BB%AC%E4%BB%80%E4%B9%88%EF%BC%9F\" >\u5e15\u91d1\u68ee\u75c5\u7684\u53d1\u75c5\u673a\u5236\u544a\u8bc9\u6211\u4eec\u4ec0\u4e48\uff1f<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/www.hjtdsm.cn\/ar\/research\/ns\/pd\/19746.html\/#%E6%80%BB%E7%BB%93\" >\u603b\u7ed3<\/a><\/li><\/ul><\/nav><\/div>\n<h2 data-start=\"320\" data-end=\"342\"><span class=\"ez-toc-section\" id=\"%E4%B8%80%E3%80%81%E5%B8%95%E9%87%91%E6%A3%AE%E7%97%85%EF%BC%9A%E4%BB%8E%E2%80%9C%E6%89%8B%E6%8A%96%E2%80%9D%E5%BC%80%E5%A7%8B%E7%9A%84%E5%A4%A7%E8%84%91%E5%8D%B1%E6%9C%BA\"><\/span><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e00\u3001\u5e15\u91d1\u68ee\u75c5\uff1a\u4ece\u201c\u624b\u6296\u201d\u5f00\u59cb\u7684\u5927\u8111\u5371\u673a<\/span><\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<div class=\"no-scrollbar flex min-h-36 flex-nowrap gap-0.5 overflow-auto sm:gap-1 sm:overflow-hidden xl:min-h-44 mt-1 mb-5 [&amp;:not(:first-child)]:mt-4\">\n<div class=\"border-token-border-default relative w-32 shrink-0 overflow-hidden rounded-xl border-[0.5px] md:shrink max-h-64 sm:w-[calc((100%-0.5rem)\/3)] rounded-e-xl\">\n<div><img loading=\"lazy\" decoding=\"async\" class=\"bg-token-main-surface-tertiary m-0 h-full w-full object-cover aligncenter\" src=\"https:\/\/4g.lsznk.com\/wzuploads\/allimg\/240102\/20240412a1.jpg\" alt=\"\u5e15\u91d1\u68ee\u75c5\u7684\u53d1\u75c5\u673a\u5236\uff1a\u63ed\u5f00\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u7684\u201c\u9ed1\u5323\u5b50\u201d\" width=\"700\" height=\"421\" title=\"\"><\/div>\n<\/div>\n<\/div>\n<p data-start=\"386\" data-end=\"428\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><a href=\"https:\/\/www.hjtdsm.cn\/ar\/research\/ns\/19641.html\/\" target=\"_blank\" rel=\"noopener\">\u0645\u0631\u0636 \u0628\u0627\u0631\u0643\u0646\u0633\u0648\u0646<\/a>\u662f\u4e00\u79cd<\/span><\/span><strong data-start=\"393\" data-end=\"402\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8fdb\u884c\u6027\u53d1\u5c55<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7684\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\uff0c\u591a\u53d1\u4e8e\u4e2d\u8001\u5e74\u4eba\u3002\u5176\u5178\u578b\u75c7\u72b6\u5305\u62ec\uff1a<\/span><\/span><\/p>\n<ul data-start=\"429\" data-end=\"469\">\n<li data-start=\"429\" data-end=\"442\">\n<p data-start=\"431\" data-end=\"442\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u9759\u6b62\u6027\u9707\u98a4\uff08\u624b\u6296\uff09<\/span><\/span><\/p>\n<\/li>\n<li data-start=\"443\" data-end=\"451\">\n<p data-start=\"445\" data-end=\"451\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u52a8\u4f5c\u8fdf\u7f13<\/span><\/span><\/p>\n<\/li>\n<li data-start=\"452\" data-end=\"460\">\n<p data-start=\"454\" data-end=\"460\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u808c\u8089\u50f5\u786c<\/span><\/span><\/p>\n<\/li>\n<li data-start=\"461\" data-end=\"469\">\n<p data-start=\"463\" data-end=\"469\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5e73\u8861\u969c\u788d<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<p data-start=\"471\" data-end=\"504\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8fd9\u80cc\u540e\u7684\u6839\u672c\u539f\u56e0\uff0c\u662f\u5927\u8111\u4e2d\u4e00\u4e2a\u540d\u4e3a\u201c<\/span><\/span><strong data-start=\"489\" data-end=\"495\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u9ed1\u8d28<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u201d\u7684\u533a\u57df\u51fa\u4e86\u95ee\u9898\u3002<\/span><\/span><\/p>\n<p data-start=\"506\" data-end=\"611\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u53ef\u4ee5\u8fd9\u6837\u7406\u89e3\uff1a<\/span><\/span><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5065\u5eb7\u4eba\u8111\u4e2d\u7684\u201c\u9ed1\u8d28\u2014\u7eb9\u72b6\u4f53\u901a\u8def\u201d\u5c31\u50cf\u4e00\u6761\u795e\u7ecf\u4fe1\u53f7\u7684\u201c\u9ad8\u901f\u516c\u8def\u201d\uff0c\u8d1f\u8d23\u534f\u8c03\u8eab\u4f53\u7684\u8fd0\u52a8\u3002\u5f53\u9ed1\u8d28\u91cc\u7684\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u53d7\u635f\u540e\uff0c\u8fd9\u6761\u201c\u9ad8\u901f\u8def\u201d\u5f00\u59cb\u5835\u585e\uff0c\u4fe1\u53f7\u4f20\u9012\u4e0d\u7545\uff0c\u8eab\u4f53\u52a8\u4f5c\u4e5f\u968f\u4e4b\u53d8\u5f97\u8fdf\u7f13\u548c\u50f5\u786c\u3002<\/span><\/span><\/p>\n<h2 data-start=\"618\" data-end=\"639\"><span class=\"ez-toc-section\" id=\"%E4%BA%8C%E3%80%81%E6%A0%B8%E5%BF%83%E7%97%85%E7%90%86%E6%94%B9%E5%8F%98%EF%BC%9A%E5%A4%9A%E5%B7%B4%E8%83%BA%E8%83%BD%E7%A5%9E%E7%BB%8F%E5%85%83%E6%8D%9F%E4%BC%A4\"><\/span><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e8c\u3001\u6838\u5fc3\u75c5\u7406\u6539\u53d8\uff1a\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u635f\u4f24<\/span><\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<div class=\"no-scrollbar flex min-h-36 flex-nowrap gap-0.5 overflow-auto sm:gap-1 sm:overflow-hidden xl:min-h-44 mt-1 mb-5 [&amp;:not(:first-child)]:mt-4\">\n<div class=\"border-token-border-default relative w-32 shrink-0 overflow-hidden rounded-xl border-[0.5px] md:shrink max-h-64 sm:w-[calc((100%-0.5rem)\/3)] rounded-e-xl\">\n<div><img decoding=\"async\" class=\"bg-token-main-surface-tertiary m-0 h-full w-full object-cover aligncenter\" src=\"https:\/\/p3-sdbk2-media.byteimg.com\/tos-cn-i-xv4ileqgde\/fe85ef4427a44807833284928faf2802~tplv-xv4ileqgde-resize-w%3A750.image\" alt=\"https:\/\/p3-sdbk2-media.byteimg.com\/tos-cn-i-xv4ileqgde\/fe85ef4427a44807833284928faf2802~tplv-xv4ileqgde-resize-w%3A750.image\" title=\"\"><\/div>\n<\/div>\n<\/div>\n<p data-start=\"683\" data-end=\"699\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5e15\u91d1\u68ee\u75c5\u6700\u6838\u5fc3\u7684\u75c5\u7406\u53d8\u5316\u662f\uff1a<\/span><\/span><strong data-start=\"702\" data-end=\"744\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u9ed1\u8d28\u81f4\u5bc6\u90e8\uff08SNc\uff09\u7684\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u9010\u6e10\u53d8\u6027\u548c\u6b7b\u4ea1\uff0c\u5bfc\u81f4\u591a\u5df4\u80fa\u6c34\u5e73\u663e\u7740\u4e0b\u964d\u3002<\/span><\/span><\/strong><\/p>\n<p data-start=\"746\" data-end=\"828\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u591a\u5df4\u80fa\u662f\u4e00\u79cd\u975e\u5e38\u91cd\u8981\u7684\u795e\u7ecf\u9012\u8d28\uff0c\u5b83\u76f8\u5f53\u4e8e\u201c\u53d1\u52a8\u673a\u7684\u6da6\u6ed1\u6cb9\u201d\uff0c\u5e2e\u52a9\u6211\u4eec\u7684\u8eab\u4f53\u5b8c\u6210\u6d41\u7545\u7684\u8fd0\u52a8\u3002\u5f53\u591a\u5df4\u80fa\u4e0d\u8db3\u65f6\uff0c\u8fd0\u52a8\u7cfb\u7edf\u51fa\u73b0\u969c\u788d\uff0c\u5c31\u8868\u73b0\u4e3a\u624b\u6296\u3001\u50f5\u786c\u3001\u884c\u52a8\u8fdf\u7f13\u7b49\u5178\u578b\u75c7\u72b6\u3002<\/span><\/span><\/p>\n<p data-start=\"830\" data-end=\"911\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6b64\u5916\uff0c\u5728\u75c5\u7406\u5207\u7247\u4e2d\u8fd8\u5e38\u5e38\u53ef\u4ee5\u770b\u5230\u88ab\u79f0\u4e3a\u201c<\/span><\/span><strong data-start=\"850\" data-end=\"871\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8def\u6613\u5c0f\u4f53\uff08Lewy bodies\uff09<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u201d\u7684\u7ed3\u6784\uff0c\u8fd9\u662f\u795e\u7ecf\u7ec6\u80de\u5185\u4e00\u79cd\u5f02\u5e38\u86cb\u767d\u805a\u96c6\u7684\u6807\u5fd7\uff0c\u4e5f\u662f\u5e15\u91d1\u68ee\u75c5\u7684\u91cd\u8981\u75c5\u7406\u7279\u5f81\u4e4b\u4e00\u3002<\/span><\/span><\/p>\n<h2><span class=\"ez-toc-section\" id=\"%E5%B8%95%E9%87%91%E6%A3%AE%E7%97%85%E7%9A%84%E5%8F%91%E7%97%85%E6%9C%BA%E5%88%B6\"><\/span><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5e15\u91d1\u68ee\u75c5\u7684\u53d1\u75c5\u673a\u5236<\/span><\/span><\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p class=\"mb0\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">PD\u7684\u75c5\u56e0\u548c\u53d1\u75c5\u673a\u5236\u6d89\u53ca\u03b1-\u7a81\u89e6\u6838\u86cb\u767d(\u03b1-syn) \u7684\u5f02\u5e38\u805a\u96c6\u3001\u7ebf\u7c92\u4f53\u529f\u80fd\u969c\u788d\u3001\u6c27\u5316\u5e94\u6fc0\u548c\u795e\u7ecf\u708e\u75c7\uff08<\/span><\/span><\/span><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u56fe1 <\/span><\/span><\/span><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff09\u3002<\/span><\/span><\/span><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-19751 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/fnins-18-1210447-g001-scaled.jpg\" alt=\"\u56fe1.\u5e15\u91d1\u68ee\u75c5\u7684\u590d\u6742\u53d1\u75c5\u673a\u5236\u3002\" width=\"2560\" height=\"1171\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/fnins-18-1210447-g001-scaled.jpg 2560w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/fnins-18-1210447-g001-300x137.jpg 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/fnins-18-1210447-g001-1024x468.jpg 1024w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/fnins-18-1210447-g001-768x351.jpg 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/fnins-18-1210447-g001-1536x702.jpg 1536w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/fnins-18-1210447-g001-2048x936.jpg 2048w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/fnins-18-1210447-g001-18x8.jpg 18w\" sizes=\"(max-width: 2560px) 100vw, 2560px\" \/><\/p>\n<h3><span class=\"ez-toc-section\" id=\"1%E5%A7%8B%E5%8A%A8%E7%8E%AF%E8%8A%82%EF%BC%9A%E5%B8%95%E9%87%91%E6%A3%AE%E7%97%85%E7%9A%84%E5%8F%91%E7%97%85%E6%9C%BA%E5%88%B6%E4%B9%8B%E4%B8%80%CE%B1-%E7%AA%81%E8%A7%A6%E6%A0%B8%E8%9B%8B%E7%99%BD%E5%BC%82%E5%B8%B8%E8%81%9A%E9%9B%86\"><\/span><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">1.<\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u59cb\u52a8\u73af\u8282\uff1a<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5e15\u91d1\u68ee\u75c5\u7684\u53d1\u75c5\u673a\u5236\u4e4b\u4e00\u03b1-\u7a81\u89e6\u6838\u86cb\u767d\u5f02\u5e38\u805a\u96c6<\/span><\/span><\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p class=\"ds-markdown-paragraph\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u9996\u5148\uff0c\u03b1-\u7a81\u89e6\u6838\u86cb\u767d\u7684\u5f02\u5e38\u805a\u96c6\u662f\u5e15\u91d1\u68ee\u75c5\u6700\u6838\u5fc3\u7684\u75c5\u7406\u6807\u5fd7\uff0c\u5b83\u76f4\u63a5\u6784\u6210\u4e86\u795e\u7ecf\u6bd2\u6027\u7684\u57fa\u7840\u3002\u5728\u73af\u5883\u6bd2\u7d20\u3001\u611f\u67d3\u7b49\u56e0\u7d20\u89e6\u53d1\u4e0b\uff0c\u539f\u672c\u6b63\u5e38\u7684\u03b1-\u7a81\u89e6\u6838\u86cb\u767d\u53d1\u751f\u9519\u8bef\u6298\u53e0\uff0c\u4ece\u53ef\u6eb6\u6027\u5355\u4f53\u8f6c\u53d8\u4e3a\u4e0d\u6eb6\u6027\u7684\u6709\u6bd2\u5be1\u805a\u4f53\u5e76\u8fdb\u4e00\u6b65\u805a\u96c6\u6210\u7ea4\u7ef4\uff0c\u6700\u7ec8\u6210\u4e3a\u8def\u6613\u4f53\u7684\u4e3b\u8981\u6210\u5206\u3002\u8fd9\u4e9b\u5f02\u5e38\u805a\u96c6\u7684\u86cb\u767d\u5bf9\u795e\u7ecf\u5143\u5177\u6709\u76f4\u63a5\u6bd2\u6027\uff0c\u5b9e\u9a8c\u8bc1\u660e\uff0c\u4eba\u4e3a\u4fc3\u8fdb\u5176\u805a\u96c6\u4f1a\u5bfc\u81f4\u8fd0\u52a8\u529f\u80fd\u969c\u788d\u548c\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u7684\u4e22\u5931\uff0c\u4ece\u800c\u5f15\u53d1\u5e15\u91d1\u68ee\u75c5\u3002<\/span><\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5176\u6b21\uff0c\u7ec6\u80de\u6e05\u9664\u673a\u5236\u7684\u5931\u6548\u662f\u5bfc\u81f4\u03b1-\u7a81\u89e6\u6838\u86cb\u767d\u5806\u79ef\u7684\u5173\u952e\u73af\u8282\u3002\u4e00\u65b9\u9762\uff0c\u795e\u7ecf\u5143\u81ea\u8eab\u7684\u86cb\u767d\u964d\u89e3\u7cfb\u7edf\u529f\u80fd\u4e0d\u826f\uff1b\u53e6\u4e00\u65b9\u9762\uff0c\u8d1f\u8d23\u201c\u5927\u8111\u6e05\u6d01\u201d\u7684\u795e\u7ecf\u80f6\u8d28\u7ec6\u80de\u529f\u80fd\u4e5f\u4e25\u91cd\u53d7\u635f\u3002\u7814\u7a76\u8868\u660e\uff0c\u5c0f\u80f6\u8d28\u7ec6\u80de\u4e2d\u7684\u6c27\u5316\u5e94\u6fc0\u4f20\u611f\u5668DJ-1\u529f\u80fd\u53d7\u635f\u4f1a\u5f15\u53d1\u708e\u75c7\u53cd\u5e94\u5e76\u524a\u5f31\u5176\u6e05\u9664\u80fd\u529b\uff0c\u800c\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u867d\u7136\u80fd\u6355\u83b7\u03b1-\u7a81\u89e6\u6838\u86cb\u767d\uff0c\u4f46\u82e5\u5176\u964d\u89e3\u80fd\u529b\u957f\u671f\u843d\u540e\u4e8e\u6355\u83b7\u80fd\u529b\uff0c\u53cd\u800c\u4f1a\u6210\u4e3a\u86cb\u767d\u84c4\u79ef\u7684\u201c\u5e2e\u51f6\u201d\uff0c\u5171\u540c\u52a0\u5267\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u7684\u9000\u5316\u3002<\/span><\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6700\u540e\uff0c\u5f02\u5e38\u805a\u96c6\u7684\u03b1-\u7a81\u89e6\u6838\u86cb\u767d\u8868\u73b0\u51fa\u7c7b\u4f3c\u670a\u75c5\u6bd2\u7684\u4f20\u64ad\u7279\u6027\uff0c\u8fd9\u4f7f\u5f97\u75c5\u7406\u53d8\u5316\u80fd\u5728\u8111\u5185\u4e0d\u65ad\u6269\u6563\u3002\u9519\u8bef\u6298\u53e0\u7684\u86cb\u767d\u805a\u96c6\u4f53\u53ef\u4ee5\u4ece\u75c5\u53d8\u795e\u7ecf\u5143\u4e2d\u91ca\u653e\uff0c\u5728LAG3\u7b49\u7279\u5b9a\u53d7\u4f53\u7684\u4ecb\u5bfc\u4e0b\uff0c\u88ab\u76f8\u90bb\u7684\u5065\u5eb7\u795e\u7ecf\u5143\u5438\u6536\u3002\u8fdb\u5165\u65b0\u7ec6\u80de\u540e\uff0c\u5b83\u4eec\u4f1a\u4f5c\u4e3a\u201c\u6a21\u677f\u201d\u8bf1\u5bfc\u6b63\u5e38\u7684\u03b1-\u7a81\u89e6\u6838\u86cb\u767d\u53d1\u751f\u540c\u6837\u7684\u9519\u8bef\u6298\u53e0\uff0c\u4ece\u800c\u5b9e\u73b0\u8de8\u7a81\u89e6\u4f20\u64ad\uff0c\u5c06\u75c5\u7406\u5f71\u54cd\u4ece\u4e2d\u8111\u9ed1\u8d28\u9010\u6b65\u6269\u6563\u5230\u5176\u4ed6\u8111\u533a\u3002\u8fd9\u4e00\u6076\u6027\u5faa\u73af\u4e0d\u4ec5\u76f4\u63a5\u5bfc\u81f4\u795e\u7ecf\u5143\u6b7b\u4ea1\uff0c\u8fd8\u4f1a\u5f15\u53d1\u6c27\u5316\u5e94\u6fc0\u3001\u7ebf\u7c92\u4f53\u529f\u80fd\u969c\u788d\u7b49\u4e0b\u6e38\u4e8b\u4ef6\uff0c\u5171\u540c\u63a8\u52a8\u5e15\u91d1\u68ee\u75c5\u7684\u53d1\u751f\u4e0e\u8fdb\u5c55\u3002<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7136\u800c\uff0c\u86cb\u767d\u8d28\u7684\u5806\u79ef\u5e76\u975e\u5b64\u7acb\u4e8b\u4ef6\uff0c\u5b83\u4e0e\u7ec6\u80de\u5185\u90e8\u7684\u201c\u6e05\u6d01\u7cfb\u7edf\u201d\u5931\u6548\u5bc6\u5207\u76f8\u5173\u3002\u5176\u4e2d\uff0c<\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u86cb\u767d\u8d28\u964d\u89e3\u7cfb\u7edf\u5931\u8c03<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff08\u5305\u62ec\u6cdb\u7d20-\u86cb\u767d\u9176\u4f53\u7cfb\u7edf\u548c\u81ea\u566c-\u6eb6\u9176\u4f53\u9014\u5f84\u7684\u529f\u80fd\u969c\u788d\uff09\u662f\u5bfc\u81f4\u03b1-\u7a81\u89e6\u6838\u86cb\u767d\u7b49\u6bd2\u6027\u86cb\u767d\u65e0\u6cd5\u88ab\u6709\u6548\u6e05\u9664\u7684\u6839\u672c\u539f\u56e0\u4e4b\u4e00\u3002\u4e0e\u6b64\u540c\u65f6\uff0c\u8fd9\u4e9b\u5f02\u5e38\u86cb\u767d\u7684\u79ef\u7d2f\uff0c\u4e0d\u4ec5\u76f4\u63a5\u6bd2\u5bb3\u795e\u7ecf\u5143\uff0c\u66f4\u5411\u5468\u56f4\u7684\u514d\u75ab\u7ec6\u80de\u53d1\u51fa\u4e86\u201c\u5371\u9669\u4fe1\u53f7\u201d\uff0c\u4ece\u800c\u70b9\u71c3\u4e86<\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u795e\u7ecf\u708e\u75c7<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7684\u718a\u718a\u70c8\u706b\u3002<\/span><\/span><\/p>\n<h3><span class=\"ez-toc-section\" id=\"2_%E5%8A%A0%E9%80%9F%E5%99%A8%EF%BC%9A%E7%A5%9E%E7%BB%8F%E7%82%8E%E7%97%87%E7%9A%84%E6%81%B6%E6%80%A7%E5%BE%AA%E7%8E%AF\"><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">2. \u52a0\u901f\u5668\uff1a\u795e\u7ecf\u708e\u75c7\u7684\u6076\u6027\u5faa\u73af<\/span><\/span><\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p class=\"ds-markdown-paragraph\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u9996\u5148\uff0c\u795e\u7ecf\u708e\u75c7\u662f\u5e15\u91d1\u68ee\u75c5\u7684\u4e00\u4e2a\u6838\u5fc3\u81f4\u75c5\u56e0\u7d20\uff0c\u4e3b\u8981\u7531\u5927\u8111\u4e2d\u7684\u514d\u75ab\u7ec6\u80de\u2014\u2014\u5c0f\u80f6\u8d28\u7ec6\u80de\u548c\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u7684\u8fc7\u5ea6\u6d3b\u5316\u6240\u9a71\u52a8\u3002\u5f53\u8fd9\u4e9b\u7ec6\u80de\u88ab\u5f02\u5e38\u6fc0\u6d3b\u540e\uff0c\u4f1a\u91ca\u653e\u5927\u91cf\u7684\u4fc3\u708e\u7ec6\u80de\u56e0\u5b50\uff0c\u5982IL-1\u03b2\u3001IL-6\u548cTNF-\u03b1\u3002\u7814\u7a76\u8868\u660e\uff0c\u50cf\u80f6\u8d28\u7ec6\u80de\u6210\u719f\u56e0\u5b50\uff08GMF\uff09\u8fd9\u6837\u7684\u4fc3\u708e\u86cb\u767d\u7684\u8fc7\u5ea6\u8868\u8fbe\uff0c\u4f1a\u52a0\u5267\u8fd9\u4e00\u8fc7\u7a0b\uff1b\u53cd\u4e4b\uff0c\u6291\u5236\u5176\u8868\u8fbe\u5219\u80fd\u51cf\u8f7b\u708e\u75c7\u3001\u4fdd\u62a4\u795e\u7ecf\u5143\u5e76\u6539\u5584\u8fd0\u52a8\u529f\u80fd\uff0c\u8fd9\u76f4\u63a5\u8bc1\u660e\u4e86\u5c0f\u80f6\u8d28\u7ec6\u80de\u4ecb\u5bfc\u7684\u708e\u75c7\u5bf9\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u5177\u6709\u76f4\u63a5\u7684\u6bd2\u6027\u4f5c\u7528\u3002<\/span><\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5176\u6b21\uff0c\u795e\u7ecf\u708e\u75c7\u4e0e\u5e15\u91d1\u68ee\u75c5\u7684\u5176\u4ed6\u6838\u5fc3\u75c5\u7406\u8fc7\u7a0b\uff0c\u7279\u522b\u662f\u03b1-\u7a81\u89e6\u6838\u86cb\u767d\u7684\u5f02\u5e38\u805a\u96c6\uff0c\u5f62\u6210\u4e86\u6076\u6027\u5faa\u73af\u3002\u4e00\u65b9\u9762\uff0c\u03b1-\u7a81\u89e6\u6838\u86cb\u767d\u7684\u805a\u96c6\u53ef\u4ee5\u6fc0\u6d3b\u5c0f\u80f6\u8d28\u7ec6\u80de\uff0c\u5f15\u53d1\u708e\u75c7\u53cd\u5e94\uff1b\u53e6\u4e00\u65b9\u9762\uff0c\u6301\u7eed\u5b58\u5728\u7684\u708e\u75c7\u73af\u5883\u53c8\u4f1a\u8fdb\u4e00\u6b65\u4fc3\u8fdb\u03b1-\u7a81\u89e6\u6838\u86cb\u767d\u7684\u9519\u8bef\u6298\u53e0\u548c\u805a\u96c6\uff0c\u5e76\u635f\u5bb3\u795e\u7ecf\u5143\u7684\u529f\u80fd\u3002\u8fd9\u79cd\u4e92\u4e3a\u56e0\u679c\u7684\u5173\u7cfb\u6781\u5927\u5730\u52a0\u5267\u4e86\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u7684\u9000\u5316\uff0c\u52a0\u901f\u4e86\u75be\u75c5\u7684\u8fdb\u5c55\u3002<\/span><\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6700\u540e\uff0c\u5e15\u91d1\u68ee\u75c5\u4e2d\u7684\u795e\u7ecf\u708e\u75c7\u5e76\u4e0d\u4ec5\u9650\u4e8e\u5927\u8111\u5185\u90e8\uff0c\u8fd8\u6d89\u53ca\u5916\u5468\u514d\u75ab\u7cfb\u7edf\u7684\u53c2\u4e0e\u3002\u5728\u60a3\u8005\u548c\u52a8\u7269\u6a21\u578b\u4e2d\uff0c\u53ef\u4ee5\u53d1\u73b0\u88ab\u6fc0\u6d3b\u7684\u5916\u5468\u514d\u75ab\u7ec6\u80de\u6d78\u6da6\u5230\u9ed1\u8d28\u548c\u7eb9\u72b6\u4f53\u7b49\u5173\u952e\u8111\u533a\u3002\u8fd9\u8868\u660e\uff0c\u5e15\u91d1\u68ee\u75c5\u7684\u708e\u75c7\u53cd\u5e94\u662f\u4e00\u4e2a\u6d89\u53ca\u4e2d\u67a2\u4e0e\u5916\u5468\u514d\u75ab\u7cfb\u7edf\u7684\u5168\u5c40\u6027\u8fc7\u7a0b\u3002\u5c3d\u7ba1\u5176\u5177\u4f53\u673a\u5236\u5c1a\u672a\u5b8c\u5168\u9610\u660e\uff0c\u4f46\u6240\u6709\u8bc1\u636e\u90fd\u660e\u786e\u6307\u51fa\uff0c\u9776\u5411\u8c03\u63a7\u80f6\u8d28\u7ec6\u80de\u4ecb\u5bfc\u7684\u795e\u7ecf\u708e\u75c7\uff0c\u6709\u671b\u6210\u4e3a\u672a\u6765\u5e15\u91d1\u68ee\u75c5\u6cbb\u7597\u7684\u65b0\u7b56\u7565\u3002<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6301\u7eed\u7684\u795e\u7ecf\u708e\u75c7\u4f1a\u5927\u91cf\u4ea7\u751f\u6d3b\u6027\u6c27\uff08ROS\uff09\u7b49\u81ea\u7531\u57fa\uff0c\u4f7f\u795e\u7ecf\u5143\u9677\u5165<\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6c27\u5316\u5e94\u6fc0<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7684\u6ce5\u6f6d\u3002\u800c\u6c27\u5316\u5e94\u6fc0\u7684\u73af\u5883\uff0c\u53cd\u8fc7\u6765\u53c8\u8fdb\u4e00\u6b65\u52a0\u5267\u4e86\u86cb\u767d\u8d28\u7684\u9519\u8bef\u6298\u53e0\u548c\u7ebf\u7c92\u4f53\u7684\u635f\u200b\u200b\u4f24\u3002<\/span><\/span><\/p>\n<h3><span class=\"ez-toc-section\" id=\"3_%E8%83%BD%E9%87%8F%E5%8D%B1%E6%9C%BA%E4%B8%8E%E6%AF%92%E6%80%A7%E7%8E%AF%E5%A2%83%EF%BC%9A%E7%BA%BF%E7%B2%92%E4%BD%93%E5%8A%9F%E8%83%BD%E9%9A%9C%E7%A2%8D%E4%B8%8E%E6%B0%A7%E5%8C%96%E5%BA%94%E6%BF%80\"><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">3. \u80fd\u91cf\u5371\u673a\u4e0e\u6bd2\u6027\u73af\u5883\uff1a\u7ebf\u7c92\u4f53\u529f\u80fd\u969c\u788d\u4e0e\u6c27\u5316\u5e94\u6fc0<\/span><\/span><\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<h3><span class=\"ez-toc-section\" id=\"%E6%B0%A7%E5%8C%96%E5%BA%94%E6%BF%80\"><\/span><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6c27\u5316\u5e94\u6fc0<\/span><\/span><\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p class=\"ds-markdown-paragraph\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u9996\u5148\uff0c\u6c27\u5316\u5e94\u6fc0\u662f\u5e15\u91d1\u68ee\u75c5\u53d1\u75c5\u7684\u4e00\u4e2a\u6838\u5fc3\u9a71\u52a8\u56e0\u7d20\uff0c\u5176\u672c\u8d28\u662f\u6d3b\u6027\u6c27\uff08ROS\uff09\u7684\u8fc7\u91cf\u4ea7\u751f\u4e0e\u7ec6\u80de\u6e05\u9664\u80fd\u529b\u4e4b\u95f4\u7684\u5931\u8861\u3002\u5728\u751f\u7406\u72b6\u6001\u4e0b\uff0cROS\u53c2\u4e0e\u6b63\u5e38\u7684\u7ec6\u80de\u4fe1\u53f7\u8f6c\u5bfc\uff0c\u4f46\u5728\u5e15\u91d1\u68ee\u75c5\u60a3\u8005\u9ed1\u8d28\u7eb9\u72b6\u4f53\u533a\u57df\uff0cROS\u7684\u8fc7\u5ea6\u79ef\u805a\u4f1a\u5bfc\u81f4\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u7684\u80fd\u91cf\u4ee3\u8c22\u5931\u8861\uff0c\u4f7f\u5176\u80fd\u91cf\u9700\u6c42\u8fdc\u8d85\u4f9b\u5e94\uff0c\u6700\u7ec8\u76f4\u63a5\u5f15\u8d77\u795e\u7ecf\u5143\u635f\u4f24\u3001\u51cb\u4ea1\uff0c\u5e76\u8bf1\u53d1\u03b1-\u7a81\u89e6\u6838\u86cb\u767d\u7684\u5f02\u5e38\u805a\u96c6\u3002<\/span><\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5176\u6b21\uff0c\u6c27\u5316\u5e94\u6fc0\u5e76\u975e\u4e00\u4e2a\u5b64\u7acb\u7684\u4e8b\u4ef6\uff0c\u5b83\u4e0e\u5e15\u91d1\u68ee\u75c5\u7684\u5176\u4ed6\u5173\u952e\u81f4\u75c5\u673a\u5236\u5f62\u6210\u4e86\u7d27\u5bc6\u7684\u6076\u6027\u5faa\u73af\u3002\u8fc7\u91cf\u7684ROS\u4f1a\u635f\u5bb3\u7ebf\u7c92\u4f53\u529f\u80fd\uff0c\u524a\u5f31\u5176\u81ea\u566c\u80fd\u529b\uff0c\u4ece\u800c\u8fdb\u4e00\u6b65\u52a0\u5267ROS\u7684\u751f\u6210\u3002\u540c\u65f6\uff0c\u6c27\u5316\u5e94\u6fc0\u8fd8\u80fd\u6fc0\u6d3b\u5c0f\u80f6\u8d28\u7ec6\u80de\uff0c\u4fc3\u4f7f\u5176\u91ca\u653e\u5927\u91cf\u708e\u75c7\u56e0\u5b50\uff0c\u4ece\u800c\u5f15\u53d1\u5e76\u653e\u5927\u795e\u7ecf\u708e\u75c7\u53cd\u5e94\uff0c\u5171\u540c\u6784\u6210\u4e00\u4e2a\u63a8\u52a8\u795e\u7ecf\u5143\u9000\u884c\u7684destructive \u7f51\u7edc\u3002<\/span><\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6700\u540e\uff0c\u673a\u4f53\u5185\u6e90\u7684\u6297\u6c27\u5316\u9632\u5fa1\u7cfb\u7edf\uff0c\u5982\u8f6c\u5f55\u56e0\u5b50Nrf2\uff0c\u662f\u62b5\u6297\u6c27\u5316\u5e94\u6fc0\u7684\u5173\u952e\u3002 Nrf2\u901a\u8def\u80fd\u591f\u4e0a\u8c03\u6297\u6c27\u5316\u9176\u548c\u57fa\u56e0\u7684\u8868\u8fbe\uff0c\u589e\u5f3a\u795e\u7ecf\u5143\u5bf9ROS\u7684\u62b5\u6297\u529b\u3002\u7814\u7a76\u4e5f\u8868\u660e\uff0c\u50cfToll\u6837\u53d7\u4f534\uff08TLR4\uff09\u8fd9\u6837\u7684\u4fe1\u53f7\u5206\u5b50\u901a\u8fc7\u8c03\u63a7\u6c27\u5316\u8fd8\u539f\u654f\u611f\u7684AP-1\u8f6c\u5f55\u56e0\u5b50\uff0c\u5728ROS\u53cd\u5e94\u4e2d\u626e\u6f14\u91cd\u8981\u89d2\u8272\uff0c\u6572\u9664TLR4\u88ab\u8bc1\u5b9e\u53ef\u51cf\u8f7b\u6c27\u5316\u635f\u4f24\u5e76\u6539\u5584\u8fd0\u52a8\u75c7\u72b6\u3002\u8fd9\u4e9b\u8bc1\u636e\u4e0d\u4ec5\u8bc1\u5b9e\u4e86\u6c27\u5316\u5e94\u6fc0\u7684\u6838\u5fc3\u5730\u4f4d\uff0c\u4e5f\u63d0\u793a\u9488\u5bf9\u8fd9\u4e9b\u901a\u8def\uff08\u5982\u6fc0\u6d3bNrf2\uff09\u53ef\u80fd\u6210\u4e3a\u6f5c\u5728\u7684\u6cbb\u7597\u7b56\u7565\u3002<\/span><\/span><\/p>\n<h3><span class=\"ez-toc-section\" id=\"%E7%BA%BF%E7%B2%92%E4%BD%93%E5%8A%9F%E8%83%BD%E9%9A%9C%E7%A2%8D\"><\/span><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7ebf\u7c92\u4f53\u529f\u80fd\u969c\u788d<\/span><\/span><\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p class=\"ds-markdown-paragraph\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u9996\u5148\uff0c\u7ebf\u7c92\u4f53\u529f\u80fd\u969c\u788d\u662f\u5e15\u91d1\u68ee\u75c5\u4e2d\u5bfc\u81f4\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u6b7b\u4ea1\u7684\u6838\u5fc3\u73af\u8282\u3002\u529f\u80fd\u53d7\u635f\u7684\u7ebf\u7c92\u4f53\u4f1a\u9020\u6210\u7ec6\u80de\u80fd\u91cf\u8d27\u5e01ATP\u7684\u5408\u6210\u6025\u5267\u51cf\u5c11\uff0c\u540c\u65f6\u4ea7\u751f\u8fc7\u91cf\u7684\u81ea\u7531\u57fa\uff0c\u7834\u574f\u7ec6\u80de\u5185\u7684\u9499\u79bb\u5b50\u7a33\u6001\u3002\u8fd9\u79cd\u80fd\u91cf\u5371\u673a\u4e0e\u6bd2\u6027\u73af\u5883\u4f7f\u5f97\u9ad8\u80fd\u8017\u3001\u9ad8\u4ee3\u8c22\u9700\u6c42\u7684\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u5c24\u5176\u8106\u5f31\uff0c\u6700\u7ec8\u56e0\u65e0\u6cd5\u7ef4\u6301\u6b63\u5e38\u529f\u80fd\u800c\u8d70\u5411\u9000\u884c\u6027\u75c5\u53d8\u3002<\/span><\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5176\u6b21\uff0c\u4e0e\u5e15\u91d1\u68ee\u75c5\u76f8\u5173\u7684\u591a\u4e2a\u81f4\u75c5\u57fa\u56e0\uff0c\u5176\u529f\u80fd\u76f4\u63a5\u6307\u5411\u4e86\u7ebf\u7c92\u4f53\u8d28\u91cf\u63a7\u5236\u7684\u5931\u7075\uff0c\u7279\u522b\u662f\u201c\u7ebf\u7c92\u4f53\u81ea\u566c\u201d\u8fd9\u4e00\u5173\u952e\u8fc7\u7a0b\u3002\u4f8b\u5982\uff0cPINK1\u548cPRKN\u57fa\u56e0\u7684\u7a81\u53d8\u4f1a\u7834\u574f\u5176\u4ecb\u5bfc\u7684\u6e05\u7406\u53d7\u635f\u7ebf\u7c92\u4f53\u7684\u901a\u8def\uff0c\u5bfc\u81f4\u529f\u80fd\u5f02\u5e38\u7684\u7ebf\u7c92\u4f53\u5728\u7ec6\u80de\u5185\u5806\u79ef\uff0c\u5e76\u91ca\u653emtDNA\u7b49\u7269\u8d28\uff0c\u8fdb\u800c\u89e6\u53d1\u6709\u5bb3\u7684\u795e\u7ecf\u708e\u75c7\u53cd\u5e94\uff0c\u5f62\u6210\u6076\u6027\u5faa\u73af\uff0c\u52a0\u901f\u795e\u7ecf\u5143\u6b7b\u4ea1\u3002<\/span><\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6700\u540e\uff0c\u7ebf\u7c92\u4f53\u529f\u80fd\u969c\u788d\u7684\u5f71\u54cd\u8fd8\u5ef6\u4f38\u81f3\u5176\u52a8\u6001\u5206\u5e03\u4e0e\u751f\u7269\u5408\u6210\u3002\u7814\u7a76\u53d1\u73b0\uff0cLRRK2\u57fa\u56e0\u7684\u7a81\u53d8\u4f1a\u5e72\u6270\u7ebf\u7c92\u4f53\u5728\u795e\u7ecf\u5143\u957f\u8f74\u7a81\u4e2d\u7684\u6b63\u5e38\u8fd0\u8f93\uff0c\u4f7f\u5176\u65e0\u6cd5\u5230\u8fbe\u9700\u8981\u80fd\u91cf\u7684\u90e8\u4f4d\uff1b\u800c\u8c03\u63a7\u7ebf\u7c92\u4f53\u65b0\u751f\u7684\u5173\u952e\u56e0\u5b50PGC-1\u03b1\u7684\u4e0b\u8c03\uff0c\u5219\u524a\u5f31\u4e86\u7ec6\u80de\u66ff\u6362\u548c\u4fee\u590d\u7ebf\u7c92\u4f53\u7f51\u7edc\u7684\u80fd\u529b\u3002\u8fd9\u4e9b\u673a\u5236\u5171\u540c\u8868\u660e\uff0c\u7ebf\u7c92\u4f53\u7cfb\u7edf\u7684\u5168\u9762\u5931\u8c03\u662f\u63a8\u52a8\u5e15\u91d1\u68ee\u75c5\u795e\u7ecf\u9000\u884c\u6027\u53d8\u7684\u4e00\u4e2a\u6839\u672c\u6027\u539f\u56e0\u3002<\/span><\/span><\/p>\n<p class=\"mb0\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7efc\u4e0a\u6240\u8ff0\uff0c\u5e15\u91d1\u68ee\u75c5\u7684\u53d1\u75c5\u673a\u5236\u662f\u4e00\u4e2a\u7531\u591a\u6761\u901a\u8def\u6784\u6210\u7684\u6076\u6027\u5faa\u73af\u7f51\u7edc\uff08\u5982\u56fe1\u6240\u793a\uff09\u3002<\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7ebf\u7c92\u4f53\u529f\u80fd\u969c\u788d<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u548c<\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u86cb\u767d\u8d28\u964d\u89e3\u7cfb\u7edf\u5931\u8c03<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u662f\u4e24\u5927\u4e0a\u6e38\u59cb\u52a8\u56e0\u7d20\uff0c\u5b83\u4eec\u5bfc\u81f4<\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6c27\u5316\u5e94\u6fc0<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u548c<\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03b1-\u7a81\u89e6\u6838\u86cb\u767d<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7684\u5f02\u5e38\u805a\u96c6\u3002\u800c\u5f02\u5e38\u805a\u96c6\u7684\u03b1-\u7a81\u89e6\u6838\u86cb\u767d\u4e00\u65b9\u9762\u76f4\u63a5\u635f\u4f24\u795e\u7ecf\u5143\uff0c\u53e6\u4e00\u65b9\u9762\u6fc0\u6d3b<\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u795e\u7ecf\u708e\u75c7<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff1b\u795e\u7ecf\u708e\u75c7\u548c\u6c27\u5316\u5e94\u6fc0\u53c8\u53cd\u8fc7\u6765\u8fdb\u4e00\u6b65\u52a0\u91cd\u7ebf\u7c92\u4f53\u635f\u4f24\u548c\u86cb\u767d\u8d28\u805a\u96c6\u3002\u8fd9\u4e2a\u81ea\u6211\u5f3a\u5316\u7684\u7834\u574f\u6027\u5faa\u73af\uff0c\u6700\u7ec8\u5bfc\u81f4\u9ed1\u8d28\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u65e0\u53ef\u633d\u56de\u7684\u6b7b\u4ea1\u3002<\/span><\/span><\/p>\n<h3 data-start=\"1309\" data-end=\"1328\"><span class=\"ez-toc-section\" id=\"4_%E9%81%97%E4%BC%A0%E4%B8%8E%E7%8E%AF%E5%A2%83%E5%9B%A0%E7%B4%A0%E7%9A%84%E4%BA%A4%E4%BA%92\"><\/span><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">4. \u9057\u4f20\u4e0e\u73af\u5883\u56e0\u7d20\u7684\u4ea4\u4e92<\/span><\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<ul>\n<li data-start=\"1331\" data-end=\"1364\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e00\u4e9b\u5bb6\u65cf\u6027\u5e15\u91d1\u68ee\u75c5\u60a3\u8005\u5b58\u5728\u57fa\u56e0\u7a81\u53d8\uff08\u5982SNCA\u3001LRRK2\uff09\u3002<\/span><\/span><\/li>\n<li data-start=\"1331\" data-end=\"1364\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u519c\u836f\u63a5\u89e6\u3001\u91cd\u91d1\u5c5e\u66b4\u9732\u3001\u8111\u5916\u4f24\u7b49\u73af\u5883\u56e0\u7d20\u4e5f\u53ef\u80fd\u63d0\u9ad8\u60a3\u75c5\u98ce\u9669\u3002<\/span><\/span><\/li>\n<\/ul>\n<p data-start=\"1367\" data-end=\"1424\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: 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data-end=\"1783\">\n<p data-start=\"1756\" data-end=\"1783\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5e72\u7ec6\u80de\u79fb\u690d\u4e0e\u57fa\u56e0\u6cbb\u7597\u4e5f\u88ab\u89c6\u4e3a\u672a\u6765\u53ef\u80fd\u6539\u53d8\u75c5\u7a0b\u7684\u521b\u65b0\u624b\u6bb5<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<p data-start=\"1785\" data-end=\"1830\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u867d\u7136\u5e15\u91d1\u68ee\u75c5\u5c1a\u65e0\u6839\u6cbb\u65b9\u6cd5\uff0c\u4f46\u968f\u7740\u673a\u5236\u7814\u7a76\u7684\u6df1\u5165\uff0c\u6211\u4eec\u6b63\u5728\u9010\u6b65\u201c\u7834\u89e3\u201d\u8fd9\u4e00\u75be\u75c5\u7684\u5bc6\u7801\u3002<\/span><\/span><\/p>\n<h2><span class=\"ez-toc-section\" id=\"%E6%80%BB%E7%BB%93\"><\/span><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u603b\u7ed3<\/span><\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p class=\"ds-markdown-paragraph\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: 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dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u66f4\u52a0\u6ce8\u91cd\u591a\u9014\u5f84\u3001\u591a\u9776\u70b9\u7684\u8054\u5408\u5e72\u9884<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff0c\u4f8b\u5982\u5f00\u53d1\u80fd\u591f\u540c\u65f6\u6291\u5236\u03b1-\u7a81\u89e6\u6838\u86cb\u767d\u805a\u96c6\u3001\u7f13\u89e3\u6c27\u5316\u5e94\u6fc0\u5e76\u4fdd\u62a4\u7ebf\u7c92\u4f53\u529f\u80fd\u7684\u5316\u5408\u7269\u3002<\/span><\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u57fa\u4e8e\u4e0a\u8ff0\u53d1\u75c5\u673a\u5236\u7684\u6df1\u5165\u7406\u89e3\uff0c\u4e0b\u4e00\u7bc7\u6587\u7ae0\u6211\u4eec\u5c06\u7cfb\u7edf\u76d8\u70b9\u5e15\u91d1\u68ee\u75c5\u7684\u73b0\u6709\u4e0e\u65b0\u5174\u6cbb\u7597\u65b9\u6cd5\u3002\u4ece\u7ecf\u5178\u7684\u5de6\u65cb\u591a\u5df4\u66ff\u4ee3\u7597\u6cd5\uff0c\u5230\u9488\u5bf9\u8fd9\u4e9b\u590d\u6742\u673a\u5236\u7684\u591a\u9776\u70b9\u6cbb\u7597\u7b56\u7565\uff08\u5982\u03b1-\u7a81\u89e6\u6838\u86cb\u767d\u6e05\u9664\u5242\u3001\u7ebf\u7c92\u4f53\u4fdd\u62a4\u5242\u3001\u6297\u708e\u7597\u6cd5\u7b49\uff09\uff0c\u4e43\u81f3\u6df1\u90e8\u8111\u523a\u6fc0\uff08DBS\uff09\u7b49\u5916\u79d1\u5e72\u9884\u624b\u6bb5\uff0c\u63a2\u7d22\u6211\u4eec\u5982\u4f55\u5728\u8fd9\u573a\u4e0e\u75be\u75c5\u7684\u591a\u7ebf\u4f5c\u6218\u4e2d\uff0c\u4e3a\u60a3\u8005\u8d62\u5f97\u66f4\u597d\u7684\u751f\u6d3b\u3002<\/span><\/span><\/p>\n<blockquote><p>\u53c2\u8003\u8d44\u6599\uff1a[1]:https:\/\/www.frontiersin.org\/journals\/neuroscience\/articles\/10.3389\/fnins.2024.1210447\/full<\/p><\/blockquote>","protected":false},"excerpt":{"rendered":"<p>\u5e15\u91d1\u68ee\u75c5\uff08Parkinson&#8217;s Disease\uff0cPD\uff09\u662f\u4e00\u79cd\u5e38\u89c1\u7684\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\uff0c\u5728\u5168\u7403\u7ea6\u6709\u8d85\u8fc7 [&hellip;]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[81],"tags":[159],"_links":{"self":[{"href":"https:\/\/www.hjtdsm.cn\/ar\/wp-json\/wp\/v2\/posts\/19746"}],"collection":[{"href":"https:\/\/www.hjtdsm.cn\/ar\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hjtdsm.cn\/ar\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/ar\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/ar\/wp-json\/wp\/v2\/comments?post=19746"}],"version-history":[{"count":2,"href":"https:\/\/www.hjtdsm.cn\/ar\/wp-json\/wp\/v2\/posts\/19746\/revisions"}],"predecessor-version":[{"id":19755,"href":"https:\/\/www.hjtdsm.cn\/ar\/wp-json\/wp\/v2\/posts\/19746\/revisions\/19755"}],"wp:attachment":[{"href":"https:\/\/www.hjtdsm.cn\/ar\/wp-json\/wp\/v2\/media?parent=19746"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/ar\/wp-json\/wp\/v2\/categories?post=19746"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/ar\/wp-json\/wp\/v2\/tags?post=19746"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}