{"id":20463,"date":"2025-11-13T17:59:16","date_gmt":"2025-11-13T09:59:16","guid":{"rendered":"https:\/\/www.hjtdsm.cn\/?p=20463"},"modified":"2025-11-13T17:59:16","modified_gmt":"2025-11-13T09:59:16","slug":"%e5%b9%b2%e7%bb%86%e8%83%9e%e4%b8%ba%e4%bb%80%e4%b9%88%e8%83%bd%e4%bf%ae%e5%a4%8d%e7%b3%96%e5%b0%bf%e7%97%85%e8%82%be%e7%97%85%ef%bc%9f","status":"publish","type":"post","link":"https:\/\/www.hjtdsm.cn\/ar\/stem-cells\/stem-cell-therapy\/20463.html","title":{"rendered":"\u5e72\u7ec6\u80de\u4e3a\u4ec0\u4e48\u80fd\u4fee\u590d\u7cd6\u5c3f\u75c5\u80be\u75c5\uff1f\u6700\u65b0\u7814\u7a76\u7efc\u8ff0\u8868\u660e\u4e0e\u8fd9\u56db\u5927\u673a\u5236\u606f\u606f\u76f8\u5173\uff01"},"content":{"rendered":"<section data-role=\"list\">\n<section data-role=\"list\" data-pm-slice=\"4 4 [&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;outer&quot;,&quot;label&quot;:&quot;edit by 135editor&quot;,&quot;data-pm-slice&quot;:&quot;0 0 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inherit;\">\u5e72\u7ec6\u80de\u4e3a\u4ec0\u4e48\u80fd\u4fee\u590d\u7cd6\u5c3f\u75c5\u80be\u75c5\uff1a<\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09\u4e4b\u6240\u4ee5\u80fd\u4fee\u590d\u7cd6\u5c3f\u75c5\u80be\u75c5\uff0c\u4e3b\u8981\u5f52\u56e0\u4e8e\u5176\u5f3a\u5927\u7684\u65c1\u5206\u6ccc\u6548\u5e94<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff0c\u8fd9\u4f7f\u5176\u6210\u4e3aDKD\u4e00\u79cd\u6781\u5177\u524d\u666f\u7684\u6cbb\u7597\u65b9\u6cd5\u3002<\/span><\/span><\/p>\n<section><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-20464 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/istockphoto-2205502558-612x612-1.jpg\" alt=\"\u5e72\u7ec6\u80de\u4e3a\u4ec0\u4e48\u80fd\u4fee\u590d\u7cd6\u5c3f\u75c5\u80be\u75c5\" 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inherit;\">\u8fd1\u65e5\uff0c\u4e2d\u56fd\u6c55\u5934\u5e02\u6c55\u5934\u5927\u5b66\u533b\u5b66\u9662\u9644\u5c5e\u7b2c\u4e8c\u533b\u9662\u80be\u5185\u79d1\u7684\u7814\u7a76\u4eba\u5458\u5728\u56fd\u9645\u671f\u520a\u6742\u5fd7\u4e0a\u53d1\u8868\u4e86\u4e00\u7bc7\u300a\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6cbb\u7597\u7cd6\u5c3f\u75c5\u80be\u75c5\u7684\u673a\u5236\u300b\u7684\u7814\u7a76\u7efc\u8ff0\uff0c\u56de\u7b54\u4e86\u5e72\u7ec6\u80de\u4e3a\u4ec0\u4e48\u80fd\u4fee\u590d\u7cd6\u5c3f\u75c5\u80be\u75c5\u8fd9\u4e2a\u95ee\u9898[1]\u3002<\/span><\/span><\/p>\n<section><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-20475 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-13_140410_340.png\" alt=\"\u5e72\u7ec6\u80de\u4e3a\u4ec0\u4e48\u80fd\u4fee\u590d\u7cd6\u5c3f\u75c5\u80be\u75c5\uff1f\u6700\u65b0\u7814\u7a76\u7efc\u8ff0\u8868\u660e\u4e0e\u8fd9\u56db\u5927\u673a\u5236\u606f\u606f\u76f8\u5173\uff01\" width=\"720\" height=\"410\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-13_140410_340.png 720w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-13_140410_340-300x171.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-13_140410_340-18x10.png 18w\" sizes=\"(max-width: 720px) 100vw, 720px\" \/><\/section>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7efc\u8ff0\u63a2\u8ba8\u4e86\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6cbb\u7597\u7cd6\u5c3f\u75c5\u80be\u75c5\u7684\u673a\u5236\uff0c\u5305\u62ec\u6291\u5236\u708e\u75c7\u3001\u7ea4\u7ef4\u5316\u548c\u6c27\u5316\u5e94\u6fc0\uff0c\u4ee5\u53ca\u8c03\u8282<\/span><\/span><span class=\"\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50<\/span><\/span><\/span><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff08VEGF\uff09\u3002\u6700\u540e\uff0c\u672c\u6587\u6982\u8ff0\u4e86\u5df2\u5b8c\u6210\u7684\u8bc4\u4f30MSCs\u79fb\u690d\u6cbb\u7597DKD\u60a3\u8005\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u7684\u4e34\u5e8a\u8bd5\u9a8c\u3002\u672c\u6587\u65e8\u5728\u5f3a\u8c03MSCs\u4f5c\u4e3aDKD\u521b\u65b0\u7597\u6cd5\u7684\u6f5c\u529b\uff0c\u5e76\u6307\u5bfc\u672a\u6765\u7684\u7814\u7a76\uff0c\u4ee5\u4f18\u5316\u5176\u6cbb\u7597\u5e94\u7528\uff0c\u6700\u7ec8\u6539\u5584DKD\u60a3\u8005\u7684\u751f\u6d3b\u8d28\u91cf\u3002<\/span><\/span><\/p>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_79_2 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default 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inherit;\">\u5e72\u7ec6\u80de\u4e3a\u4ec0\u4e48\u80fd\u4fee\u590d\u7cd6\u5c3f\u75c5\u80be\u75c5\uff1a\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6cbb\u7597\u7cd6\u5c3f\u75c5\u80be\u75c5\u7684\u56db\u5927\u673a\u5236<\/span><\/span><\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<h3><span class=\"ez-toc-section\" id=\"%E4%B8%80%E3%80%81%E6%8A%91%E5%88%B6%E7%82%8E%E7%97%87%EF%BC%9A%E6%9E%84%E7%AD%91%E8%82%BE%E8%84%8F%E4%BF%9D%E6%8A%A4%E9%98%B2%E7%BA%BF\"><\/span><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e00\u3001\u6291\u5236\u708e\u75c7\uff1a\u6784\u7b51\u80be\u810f\u4fdd\u62a4\u9632\u7ebf<\/span><\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6162\u6027\u708e\u75c7\u662f\u9a71\u52a8DKD\u53d1\u751f\u53d1\u5c55\u7684\u6838\u5fc3\u73af\u8282\u3002<a href=\"https:\/\/www.hjtdsm.cn\/ar\/stem-cells\/stem-cell-therapy\/20191.html\/\" target=\"_blank\" rel=\"noopener\"> \u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u901a\u8fc7\u4e00\u5957\u7cbe\u5bc6\u7684\u201c\u7ec4\u5408\u62f3\u201d\uff0c\u4ece\u4e0d\u540c\u5c42\u9762\u6784\u7b51\u5f3a\u5927\u7684\u6297\u708e\u9632\u7ebf<\/a>\u3002<\/span><\/span><\/p>\n<p><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u76f4\u63a5\u6291\u5236\u4fc3\u708e\u4fe1\u53f7\u901a\u8def\u4e0e\u56e0\u5b50\uff1a<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> MSCs\u80fd\u591f\u5206\u6ccc\u4e00\u7cfb\u5217\u5177\u6709\u751f\u7269\u6d3b\u6027\u7684\u56e0\u5b50\uff08\u5982\u809d\u7ec6\u80de\u751f\u957f\u56e0\u5b50HGF\uff09\u548c\u5916\u6ccc\u4f53\uff0c\u8fd9\u4e9b\u7269\u8d28\u53ef\u4ee5\u76f4\u63a5\u4f5c\u7528\u4e8e\u80be\u810f\u5185\u7684\u5173\u952e\u4fc3\u708e\u4fe1\u53f7\u901a\u8def\u3002\u5b83\u4eec\u901a\u8fc7\u6291\u5236\u5982NLRP3\u708e\u75c7\u5c0f\u4f53\u3001TLRs\uff08Toll\u6837\u53d7\u4f53\uff09 \u548cNOD2\u7b49\u901a\u8def\u7684\u6fc0\u6d3b\uff0c\u4ece\u6e90\u5934\u4e0a\u51cf\u5c11\u4e0b\u6e38\u4fc3\u708e\u7ec6\u80de\u56e0\u5b50\uff08\u5982IL-1\u03b2\u3001IL-18\u3001TNF-\u03b1\u548cIL-6\uff09\u7684\u4ea7\u751f\u3002\u5176\u4e2d\uff0c\u5916\u6ccc\u4f53\u643a\u5e26\u7684\u7279\u5b9amicroRNA\uff08\u5982miR-22-3p\uff09\u88ab\u8bc1\u5b9e\u662f\u6267\u884c\u8fd9\u4e00\u6291\u5236\u529f\u80fd\u7684\u5173\u952e\u5206\u5b50\u3002\u901a\u8fc7\u76f4\u63a5\u964d\u4f4e\u8fd9\u4e9b\u7834\u574f\u6027\u708e\u75c7\u56e0\u5b50\u7684\u6c34\u5e73\uff0cMSCs\u6709\u6548\u51cf\u8f7b\u4e86\u80be\u810f\u7ec6\u80de\u7684\u708e\u75c7\u635f\u4f24\u548c\u540e\u7eed\u7684\u7ea4\u7ef4\u5316\u8fdb\u7a0b\uff08\u88681\uff09\u3002<\/span><\/span><\/p>\n<section><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-20474\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-13_141110_653.png\" alt=\"\" width=\"1249\" height=\"555\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-13_141110_653.png 1249w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-13_141110_653-300x133.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-13_141110_653-1024x455.png 1024w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-13_141110_653-768x341.png 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-13_141110_653-18x8.png 18w\" sizes=\"(max-width: 1249px) 100vw, 1249px\" \/><\/section>\n<p><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8c03\u8282\u514d\u75ab\u7ec6\u80de\uff0c\u4fc3\u8fdb\u6297\u708e\u8868\u578b\u6781\u5316\uff1a<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> MSCs\u53e6\u4e00\u9879\u5173\u952e\u7684\u6297\u708e\u673a\u5236\u5728\u4e8e\u5176\u5bf9\u514d\u75ab\u7ec6\u80de\uff0c\u7279\u522b\u662f\u5de8\u566c\u7ec6\u80de\u7684\u8c03\u63a7\u3002\u5728\u7cd6\u5c3f\u75c5\u80be\u75c5\u73af\u5883\u4e2d\uff0c\u5de8\u566c\u7ec6\u80de\u901a\u5e38\u6781\u5316\u4e3a\u4fc3\u708e\u7684M1\u578b\uff0c\u52a0\u5267\u7ec4\u7ec7\u635f\u4f24\u3002 MSCs\u53ca\u5176\u5916\u6ccc\u4f53\u80fd\u591f\u901a\u8fc7\u591a\u79cd\u4fe1\u53f7\u901a\u8def\uff08\u5982\u6291\u5236TRAF6\/STAT1\u901a\u8def\u3001\u6fc0\u6d3bPI3K\/Akt\u901a\u8def\u6216\u589e\u5f3aTFEB\u4ecb\u5bfc\u7684\u81ea\u566c\uff09\uff0c\u4e3b\u52a8\u5c06\u5de8\u566c\u7ec6\u80de\u4eceM1\u578b\u6781\u5316\u4e3a\u5177\u6709\u6297\u708e\u548c\u7ec4\u7ec7\u4fee\u590d\u529f\u80fd\u7684M2\u578b\u3002\u7814\u7a76\u8868\u660e\uff0c<\/span><\/span><span data-pm-slice=\"4 4 [&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;outer&quot;,&quot;label&quot;:&quot;edit by 135editor&quot;,&quot;data-pm-slice&quot;:&quot;0 0 []&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;paragraph&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;outer&quot;,&quot;label&quot;:&quot;edit by 135editor&quot;,&quot;data-pm-slice&quot;:&quot;0 0 []&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;paragraph&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;list&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;list&quot;,&quot;data-pm-slice&quot;:&quot;4 4 [\\&quot;para\\&quot;,{\\&quot;tagName\\&quot;:\\&quot;section\\&quot;,\\&quot;attributes\\&quot;:{\\&quot;data-role\\&quot;:\\&quot;outer\\&quot;,\\&quot;label\\&quot;:\\&quot;edit by 135editor\\&quot;,\\&quot;data-pm-slice\\&quot;:\\&quot;0 0 []\\&quot;},\\&quot;namespaceURI\\&quot;:\\&quot;http:\/\/www.w3.org\/1999\/xhtml\\&quot;},\\&quot;para\\&quot;,{\\&quot;tagName\\&quot;:\\&quot;section\\&quot;,\\&quot;attributes\\&quot;:{\\&quot;data-role\\&quot;:\\&quot;paragraph\\&quot;},\\&quot;namespaceURI\\&quot;:\\&quot;http:\/\/www.w3.org\/1999\/xhtml\\&quot;}]&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;p&quot;,&quot;attributes&quot;:{},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;}]\"><span dir=\"auto\" data-pm-slice=\"0 0 []\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">hUMSC-Exo\u53ef\u6539\u5584\u80be\u5c0f\u7403\u8db3\u7ec6\u80de\u5f62\u6001\uff0c\u589e\u5f3a\u8db3\u7ec6\u80de\u6d3b\u529b\uff0c\u5e76\u51cf\u5c11\u5c3f\u767d\u86cb\u767d\u6392\u6cc4\uff0c\u4ece\u800c\u6709\u52a9\u4e8e\u5ef6\u7f13DKD\u7684\u8fdb\u5c55\uff08\u88681 <\/span><\/span><\/span><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff1b\u56fe1 <\/span><\/span><\/span><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff09\u3002<\/span><\/span><\/span><\/span><\/p>\n<div id=\"attachment_20470\" style=\"width: 2018px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-20470\" class=\"wp-image-20470 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5fae\u4fe1\u56fe\u7247_2025-11-13_141433_104.png\" alt=\"\" width=\"2008\" height=\"863\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5fae\u4fe1\u56fe\u7247_2025-11-13_141433_104.png 2008w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5fae\u4fe1\u56fe\u7247_2025-11-13_141433_104-300x129.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5fae\u4fe1\u56fe\u7247_2025-11-13_141433_104-1024x440.png 1024w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5fae\u4fe1\u56fe\u7247_2025-11-13_141433_104-768x330.png 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5fae\u4fe1\u56fe\u7247_2025-11-13_141433_104-1536x660.png 1536w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5fae\u4fe1\u56fe\u7247_2025-11-13_141433_104-18x8.png 18w\" sizes=\"(max-width: 2008px) 100vw, 2008px\" \/><p id=\"caption-attachment-20470\" class=\"wp-caption-text\">\u56fe1\uff1a\u8110\u5e26\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u53ef\u5206\u6ccc\u5916\u6ccc\u4f53\u4ee5\u7f13\u89e3\u7cd6\u5c3f\u75c5\u80be\u75c5\uff0c\u800c\u5916\u6ccc\u4f53\u4e2d\u7684microRNA\u53ef\u80fd\u5728\u6b64\u8fc7\u7a0b\u4e2d\u53d1\u6325\u5173\u952e\u4f5c\u7528\u3002<\/p><\/div>\n<p><span data-pm-slice=\"4 4 [&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;outer&quot;,&quot;label&quot;:&quot;edit by 135editor&quot;,&quot;data-pm-slice&quot;:&quot;0 0 []&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;paragraph&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;outer&quot;,&quot;label&quot;:&quot;edit by 135editor&quot;,&quot;data-pm-slice&quot;:&quot;0 0 []&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;paragraph&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;list&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;list&quot;,&quot;data-pm-slice&quot;:&quot;4 4 [\\&quot;para\\&quot;,{\\&quot;tagName\\&quot;:\\&quot;section\\&quot;,\\&quot;attributes\\&quot;:{\\&quot;data-role\\&quot;:\\&quot;outer\\&quot;,\\&quot;label\\&quot;:\\&quot;edit by 135editor\\&quot;,\\&quot;data-pm-slice\\&quot;:\\&quot;0 0 []\\&quot;},\\&quot;namespaceURI\\&quot;:\\&quot;http:\/\/www.w3.org\/1999\/xhtml\\&quot;},\\&quot;para\\&quot;,{\\&quot;tagName\\&quot;:\\&quot;section\\&quot;,\\&quot;attributes\\&quot;:{\\&quot;data-role\\&quot;:\\&quot;paragraph\\&quot;},\\&quot;namespaceURI\\&quot;:\\&quot;http:\/\/www.w3.org\/1999\/xhtml\\&quot;}]&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;p&quot;,&quot;attributes&quot;:{},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;}]\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6b64\u5916\uff0c\u7814\u7a76\u4eba\u5458\u53d1\u73b0\uff0cBMSCs\uff08\u9aa8\u9ad3\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff09\u53ef\u901a\u8fc7TFEB\u4ecb\u5bfc\u7684\u81ea\u566c\u4fc3\u8fdbM2\u5de8\u566c\u7ec6\u80de\u6781\u5316\uff0c\u4ece\u800c\u51cf\u8f7b\u7cd6\u5c3f\u75c5\u80be\u75c5\uff0c\u6291\u5236\u708e\u75c7\u5e76\u51cf\u5c11DN\u5c0f\u9f20\u7684\u7cfb\u819c\u7ec6\u80de\u589e\u6b96\u548c\u57fa\u8d28\u6269\u5f20\uff08\u88681\uff1b\u56fe2\uff09\u3002<\/span><\/span><\/span><\/span><\/p>\n<section>\n<div id=\"attachment_20469\" style=\"width: 2018px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-20469\" class=\"wp-image-20469 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5fae\u4fe1\u56fe\u7247_2025-11-13_141555_133.png\" alt=\"\" width=\"2008\" height=\"1400\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5fae\u4fe1\u56fe\u7247_2025-11-13_141555_133.png 2008w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5fae\u4fe1\u56fe\u7247_2025-11-13_141555_133-300x209.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5fae\u4fe1\u56fe\u7247_2025-11-13_141555_133-1024x714.png 1024w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5fae\u4fe1\u56fe\u7247_2025-11-13_141555_133-768x535.png 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5fae\u4fe1\u56fe\u7247_2025-11-13_141555_133-1536x1071.png 1536w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5fae\u4fe1\u56fe\u7247_2025-11-13_141555_133-18x12.png 18w\" sizes=\"(max-width: 2008px) 100vw, 2008px\" \/><p id=\"caption-attachment-20469\" class=\"wp-caption-text\">\u56fe2\uff1a\u5229\u7528\u4e0d\u540c\u6765\u6e90\u7684\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u901a\u8fc7\u4e0d\u540c\u7684\u4fe1\u53f7\u901a\u8def\u7f13\u89e3\u52a8\u7269\u6a21\u578b\u4e2d\u7684\u7cd6\u5c3f\u75c5\u80be\u75c5\u3002<\/p><\/div>\n<\/section>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8fd9\u79cd\u6781\u5316\u8f6c\u53d8\u4e0d\u4ec5\u76f4\u63a5\u6291\u5236\u4e86\u708e\u75c7\u53cd\u5e94\uff0c\u8fd8\u4fc3\u8fdb\u4e86\u53d7\u635f\u80be\u810f\u7ec4\u7ec7\u7684\u4fee\u590d\u4e0e\u518d\u751f\uff0c\u4ece\u672c\u8d28\u4e0a\u6539\u5584\u4e86\u80be\u810f\u7684\u75c5\u7406\u7ed3\u6784\u3002<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7efc\u4e0a\u6240\u8ff0\uff0c\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u901a\u8fc7\u201c\u76f4\u63a5\u9776\u5411\u6291\u5236\u4fc3\u708e\u4fe1\u53f7\u201d\u548c\u201c\u5de7\u5999\u8c03\u8282\u514d\u75ab\u7ec6\u80de\u529f\u80fd\u201d\u8fd9\u4e24\u79cd\u76f8\u8f85\u76f8\u6210\u7684\u7b56\u7565\uff0c\u6784\u5efa\u4e86\u4e00\u4e2a\u5f3a\u5927\u7684\u6297\u708e\u73af\u5883\u3002\u8fd9\u4f7f\u5176\u80fd\u591f\u4ece\u5206\u5b50\u3001\u7ec6\u80de\u5230\u7ec4\u7ec7\u5c42\u9762\uff0c\u591a\u7ef4\u5ea6\u5730\u4e2d\u65ad\u7cd6\u5c3f\u75c5\u80be\u75c5\u7684\u708e\u75c7\u6838\u5fc3\u75c5\u7406\u8fc7\u7a0b\uff0c\u4e0d\u4ec5\u7f13\u89e3\u75c7\u72b6\uff0c\u66f4\u9488\u5bf9\u6f5c\u5728\u75c5\u56e0\uff0c\u5c55\u73b0\u51fa\u5de8\u5927\u7684\u6cbb\u7597\u6f5c\u529b\u3002<\/span><\/span><\/p>\n<h3><span class=\"ez-toc-section\" id=\"%E4%BA%8C%E3%80%81%E5%AF%B9%E6%8A%97%E7%BA%A4%E7%BB%B4%E5%8C%96%EF%BC%9A%E9%98%BB%E6%96%AD%E8%82%BE%E8%84%8F%E7%98%A2%E7%97%95%E5%BD%A2%E6%88%90\"><\/span><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e8c\u3001\u5bf9\u6297\u7ea4\u7ef4\u5316\uff1a\u963b\u65ad\u80be\u810f\u7622\u75d5\u5f62\u6210<\/span><\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u80be\u7ea4\u7ef4\u5316\u662fDKD\u8d70\u5411\u80be\u529f\u80fd\u8870\u7aed\u7684\u6700\u7ec8\u901a\u8def\u3002 MSCs\u901a\u8fc7\u591a\u9776\u70b9\u5e72\u9884\uff0c\u6709\u6548\u5ef6\u7f13\u4e86\u8fd9\u4e00\u4e0d\u53ef\u9006\u7684\u75c5\u7406\u8fc7\u7a0b\u3002<\/span><\/span><\/p>\n<p><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">1. \u9776\u5411\u591a\u91cd\u4fc3\u7ea4\u7ef4\u5316\u4fe1\u53f7\u901a\u8def\uff1a<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> MSCs\u53ca\u5176\u5916\u6ccc\u4f53\u80fd\u591f\u7cbe\u51c6\u5730\u5e72\u9884\u591a\u4e2a\u9a71\u52a8\u80be\u7ea4\u7ef4\u5316\u7684\u6838\u5fc3\u4fe1\u53f7\u901a\u8def\u3002\u5b83\u4eec\u901a\u8fc7\u643a\u5e26\u7684\u7279\u5b9amicroRNA\uff08\u5982miR-23a-3p\uff09\u6765\u6291\u5236KLF3\/STAT3\u8f74\uff0c\u6216\u901a\u8fc7\u65c1\u5206\u6ccc\u4f5c\u7528\u963b\u65adTLR4\/NF-\u03baB\u901a\u8def\u548c<\/span><\/span><span class=\"\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">Hedgehog<\/span><\/span><\/span><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \/SMO\u901a\u8def\uff0c\u4ece\u800c\u51cf\u5c11\u80f6\u539f\u6c89\u79ef\u548c\u7ec6\u80de\u5916\u57fa\u8d28\u7684\u5f02\u5e38\u79ef\u805a\uff08\u88681\uff09\u3002<\/span><\/span><\/p>\n<section><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-20473\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-13_141128_125.png\" alt=\"\" width=\"1249\" height=\"489\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-13_141128_125.png 1249w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-13_141128_125-300x117.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-13_141128_125-1024x401.png 1024w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-13_141128_125-768x301.png 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-13_141128_125-18x7.png 18w\" sizes=\"(max-width: 1249px) 100vw, 1249px\" \/><\/section>\n<p>\u5c24\u4e3a\u91cd\u8981\u7684\u662f\uff0cMSCs\u80fd\u76f4\u63a5\u6311\u6218\u6700\u5f3a\u5927\u7684\u4fc3\u7ea4\u7ef4\u5316\u901a\u8def\u2014\u2014TGF-\u03b2\/Smad\u4fe1\u53f7\u3002\u7814\u7a76\u53d1\u73b0\uff0cMSCs\u4e0d\u4ec5\u80fd\u6291\u5236\u7531TGF-\u03b21\u8bf1\u5bfc\u7684\u808c\u6210\u7ea4\u7ef4\u7ec6\u80de\u8f6c\u5206\u5316\uff0c\u8fd8\u80fd\u901a\u8fc7\u5176\u5206\u6ccc\u7684\u7ec6\u80de\u5916\u56ca\u6ce1\u6062\u590d\u7ec6\u80de\u5185\u7684\u6cdb\u7d20-\u86cb\u767d\u9176\u4f53\u7cfb\u7edf\uff0c\u4fc3\u8fdb\u5173\u952e\u4fc3\u7ea4\u7ef4\u5316\u86cb\u767d\uff08\u5982YAP\uff09\u7684\u964d\u89e3\uff0c\u5e76\u4eceSmad2\/3\/WTAP\/m6A\/ENO1\u7b49\u8868\u89c2\u9057\u4f20\u5c42\u9762\u591a\u7ef4\u5ea6\u5730\u4e2d\u65ad\u7ea4\u7ef4\u5316\u4fe1\u53f7\u7684\u4f20\u5bfc\u3002<\/p>\n<p><strong>2. \u8d85\u8d8a\u4f20\u7edf\u8ba4\u77e5\uff1a\u8c03\u63a7\u808c\u6210\u7ea4\u7ef4\u7ec6\u80de\u7684\u6765\u6e90\uff1a<\/strong>\u4f20\u7edf\u4e0a\u8ba4\u4e3a\uff0c\u4e0a\u76ae-\u95f4\u8d28\u8f6c\u5316\uff08EMT\uff09\u662f\u80be\u7ea4\u7ef4\u5316\u4e2d\u808c\u6210\u7ea4\u7ef4\u7ec6\u80de\u7684\u4e3b\u8981\u6765\u6e90\u3002\u7814\u7a76\u8868\u660e\uff0cMSCs\u786e\u5b9e\u53ef\u4ee5\u901a\u8fc7\u4e0a\u8ff0\u901a\u8def\u6291\u5236EMT\u76f8\u5173\u7684\u4fe1\u53f7\uff0c\u51cf\u8f7b\u7ea4\u7ef4\u5316\u3002\u7136\u800c\uff0c\u6700\u65b0\u7814\u7a76\u5bf9EMT\u7684\u6838\u5fc3\u5730\u4f4d\u63d0\u51fa\u4e86\u6311\u6218\uff0c\u6307\u51fa\u5468\u7ec6\u80de\u548c\u9a7b\u7559\u6210\u7ea4\u7ef4\u7ec6\u80de\u624d\u662f\u808c\u6210\u7ea4\u7ef4\u7ec6\u80de\u66f4\u4e3b\u8981\u7684\u6765\u6e90\u3002<\/p>\n<p>\u56e0\u6b64\uff0cMSCs\u7684\u6297\u7ea4\u7ef4\u5316\u4f5c\u7528\u4e0d\u80fd\u4ec5\u7528\u6291\u5236EMT\u6765\u89e3\u91ca\u3002\u5b83\u4eec\u5f88\u53ef\u80fd\u901a\u8fc7\u5176\u5f3a\u5927\u7684\u6297\u708e\u548c\u514d\u75ab\u8c03\u8282\u529f\u80fd\uff0c\u4ece\u6e90\u5934\u4e0a\u51cf\u5c11\u4e86\u4fc3\u4f7f\u8fd9\u4e9b\u771f\u6b63\u7684\u524d\u4f53\u7ec6\u80de\u6d3b\u5316\u7684\u708e\u75c7\u73af\u5883\u3002\u540c\u65f6\uff0cMSCs\u53ef\u80fd\u76f4\u63a5\u4f5c\u7528\u4e8e\u5468\u7ec6\u80de\u548c\u6210\u7ea4\u7ef4\u7ec6\u80de\uff0c\u6291\u5236\u5176\u5411\u81f4\u75c5\u6027\u808c\u6210\u7ea4\u7ef4\u7ec6\u80de\u7684\u8f6c\u5316\u548c\u589e\u6b96\u3002\u8fd9\u8868\u660eMSCs\u7684\u6297\u7ea4\u7ef4\u5316\u673a\u5236\u6bd4\u5355\u7eaf\u201c\u9006\u8f6cEMT\u201d\u66f4\u4e3a\u590d\u6742\u548c\u5168\u9762\u3002<\/p>\n<h3><span class=\"ez-toc-section\" id=\"%E4%B8%89%E3%80%81%E8%B0%83%E8%8A%82%E6%B0%A7%E5%8C%96%E5%BA%94%E6%BF%80%EF%BC%9A%E4%BB%8E%E6%BA%90%E5%A4%B4%E7%BB%B4%E6%8A%A4%E7%BB%86%E8%83%9E%E7%A8%B3%E6%80%81\"><\/span>\u4e09\u3001\u8c03\u8282\u6c27\u5316\u5e94\u6fc0\uff1a\u4ece\u6e90\u5934\u7ef4\u62a4\u7ec6\u80de\u7a33\u6001<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u6c27\u5316\u5e94\u6fc0\u662f\u52a0\u5267\u80be\u7ec6\u80de\u635f\u4f24\u7684\u5173\u952e\u56e0\u7d20\u3002MSCs\u901a\u8fc7\u4e00\u5957\u534f\u540c\u673a\u5236\uff0c\u4ece\u540e\u679c\u5e72\u9884\u4e0e\u6e90\u5934\u6cbb\u7406\u4e24\u65b9\u9762\u6062\u590d\u7ec6\u80de\u7a33\u6001\u3002<\/p>\n<p><strong>\u6291\u5236\u7a0b\u5e8f\u6027\u7ec6\u80de\u6b7b\u4ea1\uff1a<\/strong>\u5728DKD\u73af\u5883\u4e2d\uff0c\u8fc7\u91cf\u6d3b\u6027\u6c27\u4f1a\u89e6\u53d1\u94c1\u6b7b\u4ea1\u3001\u7ec6\u80de\u7126\u4ea1\u7b49\u65b0\u578b\u7ec6\u80de\u6b7b\u4ea1\u65b9\u5f0f\u3002MSCs\u53ca\u5176\u5916\u6ccc\u4f53\u901a\u8fc7\u91ca\u653e\u7279\u5b9amicroRNA\uff0c\u80fd\u7cbe\u51c6\u6291\u5236NLRP3\/caspase-1\u4ecb\u5bfc\u7684\u7ec6\u80de\u7126\u4ea1\uff0c\u5e76\u901a\u8fc7\u6fc0\u6d3bJNK\/KEAP1\/NRF2\u7b49\u6297\u6c27\u5316\u901a\u8def\u5bf9\u6297\u94c1\u6b7b\u4ea1\uff0c\u4ece\u800c\u4fdd\u62a4\u80be\u7ec6\u80de\uff08\u88681\uff09\u3002<\/p>\n<section><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-20472\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-13_141146_630.png\" alt=\"\" width=\"1248\" height=\"625\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-13_141146_630.png 1248w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-13_141146_630-300x150.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-13_141146_630-1024x513.png 1024w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-13_141146_630-768x385.png 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-13_141146_630-18x9.png 18w\" sizes=\"(max-width: 1248px) 100vw, 1248px\" \/><\/section>\n<p><strong>\u4fee\u590d\u7ebf\u7c92\u4f53\u529f\u80fd\uff1a<\/strong>\u5176\u6b21\uff0c\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u901a\u8fc7\u6062\u590d\u7ebf\u7c92\u4f53\u529f\u80fd\uff0c\u4ece\u6e90\u5934\u4e0a\u6539\u5584\u6c27\u5316\u8fd8\u539f\u5931\u8861\u3002\u7ebf\u7c92\u4f53\u529f\u80fd\u969c\u788d\u662f\u7cd6\u5c3f\u75c5\u80be\u75c5\u4e2d\u6c27\u5316\u5e94\u6fc0\u7684\u4e3b\u8981\u6765\u6e90\u3002MSCs\u901a\u8fc7\u4e24\u5927\u7b56\u7565\u6253\u7834\u9ad8\u8840\u7cd6\u5bfc\u81f4\u7684\u6076\u6027\u5faa\u73af\uff1a<\/p>\n<section data-role=\"list\">\n<ul class=\"list-paddingleft-2\">\n<li>\u4e00\u662f\u4fc3\u8fdb\u7ebf\u7c92\u4f53\u81ea\u566c\uff0c\u5b83\u4eec\u901a\u8fc7\u6fc0\u6d3bSIRT1-PGC-1\u03b1-TFAM\u548cAMPK\/mTOR\u7b49\u901a\u8def\uff0c\u5e2e\u52a9\u8db3\u7ec6\u80de\u7b49\u80be\u7ec6\u80de\u6e05\u9664\u53d7\u635f\u7684\u7ebf\u7c92\u4f53\uff1b<\/li>\n<li>\u4e8c\u662f\u76f4\u63a5\u8fdb\u884c\u7ebf\u7c92\u4f53\u8f6c\u79fb\uff0c\u901a\u8fc7\u96a7\u9053\u7eb3\u7c73\u7ba1\u7b49\u7ed3\u6784\u5c06\u5065\u5eb7\u7684\u7ebf\u7c92\u4f53\u79fb\u690d\u7ed9\u529f\u80fd\u53d7\u635f\u7684\u80be\u7ec6\u80de\uff08\u5982\u8db3\u7ec6\u80de\uff09\u751a\u81f3\u514d\u75ab\u7ec6\u80de\uff08\u5982\u5de8\u566c\u7ec6\u80de\uff09\uff0c\u76f4\u63a5\u8865\u5145\u5176\u80fd\u91cf\u5de5\u5382\uff0c\u6062\u590d\u6b63\u5e38\u7684\u80fd\u91cf\u4ee3\u8c22\u548c\u6297\u6c27\u5316\u80fd\u529b\u3002<\/li>\n<\/ul>\n<\/section>\n<p><strong>\u51cf\u8f7bDNA\u635f\u4f24\uff1a<\/strong>\u6700\u540e\uff0c\u9664\u4e86\u9488\u5bf9\u7ec6\u80de\u6b7b\u4ea1\u548c\u7ebf\u7c92\u4f53\u7684\u4fdd\u62a4\uff0c\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u8fd8\u81f4\u529b\u4e8e\u4fee\u590d\u6c27\u5316\u5e94\u6fc0\u9020\u6210\u7684\u76f4\u63a5\u635f\u4f24\u2014\u2014DNA\u635f\u4f24\u3002\u6301\u7eed\u7684\u9ad8\u7cd6\u548c\u6c27\u5316\u73af\u5883\u4f1a\u5bfc\u81f4\u80be\u7ec6\u80deDNA\u635f\u4f24\uff0c\u6fc0\u6d3b\u76f8\u5173\u7684\u51cb\u4ea1\u4fe1\u53f7\u3002\u7814\u7a76\u8bc1\u5b9e\uff0cMSCs\u80fd\u591f\u8c03\u63a7IGF1R-CHK2-p53\u8fd9\u4e00DNA\u635f\u4f24\u5e94\u7b54\u4fe1\u53f7\u8f74\uff0c\u51cf\u8f7b\u80be\u7ec6\u80de\u5185\u7684DNA\u635f\u4f24\u79ef\u7d2f\uff0c\u4ece\u800c\u963b\u6b62\u7ec6\u80de\u8d70\u5411\u8870\u8001\u6216\u51cb\u4ea1\uff0c\u4e3a\u4fdd\u62a4\u80be\u810f\u529f\u80fd\u63d0\u4f9b\u4e86\u53c8\u4e00\u91cd\u6df1\u5c42\u4fdd\u969c\u3002<\/p>\n<p>\u7efc\u4e0a\u6240\u8ff0\uff0cMSCs\u901a\u8fc7\u591a\u7ef4\u5ea6\u3001\u534f\u540c\u4f5c\u7528\u7684\u65b9\u5f0f\u8c03\u8282\u6c27\u5316\u5e94\u6fc0\uff0c\u6784\u6210\u4e86\u5176\u6cbb\u7597\u7cd6\u5c3f\u75c5\u80be\u75c5\u7684\u91cd\u8981\u673a\u5236\u57fa\u7840\u3002<\/p>\n<h3><span class=\"ez-toc-section\" id=\"%E5%9B%9B%E3%80%81%E8%B0%83%E8%8A%82VEGF%E6%B0%B4%E5%B9%B3%EF%BC%9A%E5%AE%9E%E7%8E%B0%E8%A1%80%E7%AE%A1%E7%A8%B3%E6%80%81%E7%9A%84%E7%B2%BE%E5%87%86%E8%B0%83%E6%8E%A7\"><\/span>\u56db\u3001\u8c03\u8282VEGF\u6c34\u5e73\uff1a\u5b9e\u73b0\u8840\u7ba1\u7a33\u6001\u7684\u7cbe\u51c6\u8c03\u63a7<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\u5728DKD\u4e2d\u7684\u4f5c\u7528\u590d\u6742\uff0cMSCs\u5c55\u73b0\u51fa\u5bf9\u5176\u6c34\u5e73\u7684\u667a\u80fd\u8c03\u63a7\u80fd\u529b\u3002<\/p>\n<p><strong>\u6291\u5236VEGF\u8fc7\u5ea6\u8868\u8fbe\uff1a<\/strong>\u5728DKD\u7684\u9ad8\u7cd6\u73af\u5883\u4e0b\uff0cVEGF-A\u7684\u5f02\u5e38\u9ad8\u8868\u8fbe\u4f1a\u52a0\u5267\u8840\u7ba1\u6e17\u6f0f\u548c\u80be\u5c0f\u7403\u786c\u5316\u3002MSCs\u901a\u8fc7\u5916\u6ccc\u4f53\u9012\u9001miR-16-5p\u3001miR-26a-5p\u7b49\u7279\u5b9amiRNA\uff0c\u9776\u5411VEGF\u6216\u5176\u4e0a\u6e38\u901a\u8def\uff0c\u6709\u6548\u964d\u4f4e\u5176\u6c34\u5e73\uff0c\u4fdd\u62a4\u8db3\u7ec6\u80de\u548c\u80be\u5c0f\u7403\u529f\u80fd\uff08\u88681\uff09\u3002<\/p>\n<section><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-20471\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-13_141205_541.png\" alt=\"\" width=\"1247\" height=\"352\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-13_141205_541.png 1247w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-13_141205_541-300x85.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-13_141205_541-1024x289.png 1024w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-13_141205_541-768x217.png 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-13_141205_541-18x5.png 18w\" sizes=\"(max-width: 1247px) 100vw, 1247px\" \/><\/section>\n<p><strong>\u80cc\u666f\u4f9d\u8d56\u6027\u7684\u53cc\u5411\u8c03\u8282\uff1a<\/strong>\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0cVEGF\u7684\u4f5c\u7528\u5177\u6709\u80cc\u666f\u4f9d\u8d56\u6027\u3002\u5728\u963f\u9709\u7d20\u8bf1\u5bfc\u7684\u4ee5\u5fae\u8840\u7ba1\u7a00\u758f\u4e3a\u7279\u5f81\u7684\u80be\u75c5\u4e2d\uff0cMSCs\u5206\u6ccc\u7684VEGF\u53cd\u800c\u80fd\u4fc3\u8fdb\u8840\u7ba1\u4fee\u590d\uff0c\u53d1\u6325\u4fdd\u62a4\u4f5c\u7528\u3002\u8fd9\u51f8\u663e\u4e86MSCs\u5e76\u975e\u7b80\u5355\u5347\u9ad8\u6216\u964d\u4f4eVEGF\uff0c\u800c\u662f\u80fd\u6839\u636e\u75be\u75c5\u5fae\u73af\u5883\u201c\u667a\u80fd\u201d\u5730\u8c03\u8282\u5176\u8868\u8fbe\uff0c\u65e8\u5728\u6062\u590d\u751f\u7406\u5e73\u8861\u800c\u975e\u5355\u5411\u6291\u5236\u3002<\/p>\n<p>\u7efc\u4e0a\u6240\u8ff0\uff0c\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6cbb\u7597\u7cd6\u5c3f\u75c5\u80be\u75c5\u65f6\uff0c\u5176\u5bf9VEGF\u7684\u8c03\u8282\u662f\u4e00\u4e2a\u9ad8\u5ea6\u590d\u6742\u4e14\u7cbe\u5bc6\u7684\u8fc7\u7a0b\u3002\u6838\u5fc3\u673a\u5236\u5728\u4e8e\u901a\u8fc7\u5916\u6ccc\u4f53-miRNA\u7f51\u7edc\uff0c\u6291\u5236\u5728\u9ad8\u8840\u7cd6\u73af\u5883\u4e0b\u6709\u5bb3\u7684VEGF\u8fc7\u5ea6\u8868\u8fbe\uff0c\u4ee5\u4fdd\u62a4\u8db3\u7ec6\u80de\u548c\u80be\u5c0f\u7403\u529f\u80fd\u3002\u540c\u65f6\uff0cMSCs\u5177\u5907\u6839\u636e\u75be\u75c5\u7c7b\u578b\u548c\u9636\u6bb5\u5dee\u5f02\uff0c\u5bf9VEGF\u8fdb\u884c\u53cc\u5411\u8c03\u8282\u7684\u80fd\u529b\uff0c\u8fd9\u51f8\u663e\u4e86\u5176\u4f5c\u4e3a\u4e00\u79cd\u201c\u667a\u80fd\u201d\u6cbb\u7597\u7b56\u7565\u7684\u5de8\u5927\u6f5c\u529b\uff0c\u65e8\u5728\u6062\u590dVEGF\u7684\u751f\u7406\u5e73\u8861\u800c\u975e\u5355\u7eaf\u5730\u6291\u5236\u6216\u4fc3\u8fdb\u3002<\/p>\n<h2><span class=\"ez-toc-section\" id=\"02%E3%80%81%E9%97%B4%E5%85%85%E8%B4%A8%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E7%B3%96%E5%B0%BF%E7%97%85%E8%82%BE%E7%97%85%E7%9A%84%E4%B8%B4%E5%BA%8A%E8%AF%95%E9%AA%8C\"><\/span><strong>02\u3001\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6cbb\u7597\u7cd6\u5c3f\u75c5\u80be\u75c5\u7684\u4e34\u5e8a\u8bd5\u9a8c<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"font-family: \u5b8b\u4f53;\">2016\u5e74\uff0c\u7531<\/span><span style=\"font-family: \u5b8b\u4f53;\">\u58a8\u5c14\u672c\u5927\u5b66\u80be\u810f\u7814\u7a76\u7ec4\uff08<\/span>Packham\u00a0<span style=\"font-family: \u5b8b\u4f53;\">\u56e2\u961f\uff09\u7275\u5934\uff0c\u8054\u5408<\/span><span style=\"font-family: Calibri;\">Epworth\u00a0<\/span><span style=\"font-family: \u5b8b\u4f53;\">\u533b\u5b66\u4e2d\u5fc3<\/span><span style=\"font-family: \u5b8b\u4f53;\">\u4e0e<\/span><span style=\"font-family: \u5b8b\u4f53;\">\u83ab\u7eb3\u4ec0\u5927\u5b66\u533b\u9662<\/span><span style=\"font-family: \u5b8b\u4f53;\">\u5f00\u5c55\uff0c\u7ec6\u80de\u4ea7\u54c1\u6765\u81ea<\/span><span class=\"\">Mesoblast<\/span><span style=\"font-family: \u5b8b\u4f53;\">\uff08\u7ebd\u7ea6\uff09<\/span><span style=\"font-family: \u5b8b\u4f53;\">\u3002<\/span><span style=\"font-family: \u5b8b\u4f53;\">\u7814\u7a76\u5165\u7ec4<\/span>30\u00a0<span style=\"font-family: \u5b8b\u4f53;\">\u4f4d\u4e2d\u91cd\u5ea6\u7cd6\u80be\u60a3\u8005<\/span><span style=\"font-family: \u5b8b\u4f53;\">\uff08\u57fa\u7ebf<\/span>\u00a0eGFR 20\u201350<span style=\"font-family: \u5b8b\u4f53;\">\uff09\uff0c\u968f\u673a\u63a5\u53d7<\/span><span style=\"font-family: \u5b8b\u4f53;\">\u5355\u6b21\u9759\u8109\u8f93\u6ce8<\/span>\u00a0150\u00d710\u2076\u00a0<span style=\"font-family: \u5b8b\u4f53;\">\u6216\u00a0<\/span><span style=\"font-family: Calibri;\">300\u00d710\u2076 <span class=\"\">MPC<\/span><\/span>\u00a0<span style=\"font-family: \u5b8b\u4f53;\">\u6216\u5b89\u6170\u5242\uff0c\u968f\u8bbf<\/span>60\u00a0<span style=\"font-family: \u5b8b\u4f53;\">\u5468<\/span><span style=\"font-family: \u5b8b\u4f53;\">\u3002<\/span><\/p>\n<p><span style=\"font-family: \u5b8b\u4f53;\">\u7ed3\u679c\u663e\u793a\uff1a\u708e\u75c7\u6307\u6807<\/span>IL-6\u00a0<span style=\"font-family: \u5b8b\u4f53;\">\u660e\u663e\u4e0b\u964d<\/span><span style=\"font-family: \u5b8b\u4f53;\">\uff0c\u5168\u8eab\u708e\u75c7\u53cd\u5e94\u5f97\u5230\u6539\u5584\uff1b\u80be\u529f\u80fd\uff08<\/span>eGFR\/mGFR<span style=\"font-family: \u5b8b\u4f53;\">\uff09\u4fdd\u6301\u7a33\u5b9a\u751a\u81f3\u8f7b\u5ea6\u63d0\u5347<\/span><span style=\"font-family: \u5b8b\u4f53;\">\uff0c\u708e\u75c7\u6c34\u5e73\u9ad8\u7684\u60a3\u8005\u53d7\u76ca\u66f4\u663e\u8457\uff1b\u672a\u89c1\u514d\u75ab\u6392\u65a5\u6216\u4e25\u91cd\u4e0d\u826f\u53cd\u5e94<\/span><span style=\"font-family: \u5b8b\u4f53;\">\uff0c\u5b89\u5168\u6027\u4f18\u5f02\u3002<\/span><\/p>\n<p><span style=\"font-family: \u5b8b\u4f53;\">\u4e00\u53e5\u8bdd\u603b\u7ed3\uff1a\u5728\u58a8\u5c14\u672c\u4e09\u5bb6\u533b\u9662\u89c2\u5bdf<\/span>\u00a060\u00a0<span style=\"font-family: \u5b8b\u4f53;\">\u5468\uff0c\u5355\u6b21\u00a0<\/span><span style=\"font-family: Calibri;\">150\u2013300\u00d710\u2076 MSC\u00a0<\/span><span style=\"font-family: \u5b8b\u4f53;\">\u8f93\u6ce8\uff0c\u8ba9\u60a3\u8005\u708e\u75c7\u4e0b\u964d\u3001\u80be\u529f\u80fd\u66f4\u7a33\uff0c\u5168\u7a0b\u5b89\u5168\u53ef\u9760\u3002<\/span><\/p>\n<section>\n<div id=\"attachment_20468\" style=\"width: 1047px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-20468\" class=\"wp-image-20468 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-13_143857_246.png\" alt=\"\" width=\"1037\" height=\"376\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-13_143857_246.png 1037w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-13_143857_246-300x109.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-13_143857_246-1024x371.png 1024w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-13_143857_246-768x278.png 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-13_143857_246-18x7.png 18w\" sizes=\"(max-width: 1037px) 100vw, 1037px\" \/><p id=\"caption-attachment-20468\" class=\"wp-caption-text\">\u5f02\u4f53\u95f4\u5145\u8d28\u524d\u4f53\u7ec6\u80de\uff08MPC\uff09\u6cbb\u7597\u7cd6\u5c3f\u75c5\u80be\u75c5\uff1a\u4e00\u9879\u968f\u673a\u3001\u5b89\u6170\u5242\u5bf9\u7167\u3001\u5242\u91cf\u9012\u589e\u7814\u7a76<\/p><\/div>\n<\/section>\n<p>\u7814\u7a76\u8868\u660e\uff0crexlemestrocel-L\u53ef\u901a\u8fc7\u964d\u4f4eDKD\u60a3\u8005\u7684IL-6\u6c34\u5e73\u53d1\u6325\u6297\u708e\u4f5c\u7528\u3002\u9759\u8109\u7ed9\u836f\u8010\u53d7\u6027\u826f\u597d\uff0c\u672a\u53d1\u751f\u6025\u6027\u6216\u6cbb\u7597\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\uff0c\u4e14\u6240\u6709\u53d7\u8bd5\u8005\u5747\u672a\u4ea7\u751f\u6301\u7eed\u6027\u4f9b\u4f53\u7279\u5f02\u6027\u6297<span class=\"\">HLA<\/span>\u6297\u4f53\uff0c\u51f8\u663e\u4e86\u5176\u826f\u597d\u7684\u514d\u75ab\u5b89\u5168\u6027\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u4f7f\u7528300\u00d710\u2076\u4e2arexlemestrocel-L\u6cbb\u7597\u53ef\u6539\u5584mGFR\u548ceGFR\u3002\u8fd9\u4e9b\u7ed3\u679c\u8868\u660e\uff0crexlemestrocel-L\u5b89\u5168\u6709\u6548\uff0c\u53ef\u80fd\u6709\u52a9\u4e8e\u7ef4\u6301\u80be\u529f\u80fd\uff0c\u4e3a\u6709\u80be\u79fb\u690d\u98ce\u9669\u7684\u60a3\u8005\u63d0\u4f9b\u4e86\u4e00\u79cd\u6709\u524d\u666f\u7684\u6cbb\u7597\u9009\u62e9\uff08\u88682\uff09\u3002<\/p>\n<table class=\"data last-table\">\n<thead class=\"c-article-table-head\">\n<tr>\n<th class=\"u-text-left\"><span dir=\"auto\">\u4f5c\u8005\uff0c\u5e74\u4efd<\/span><\/th>\n<th class=\"u-text-left\"><span dir=\"auto\">\u60a3\u8005<\/span><\/th>\n<th class=\"u-text-left\"><span dir=\"auto\">\u7814\u7a76\u7c7b\u578b<\/span><\/th>\n<th class=\"u-text-left\"><span dir=\"auto\">\u5e72\u7ec6\u80de\u7c7b\u578b<\/span><\/th>\n<th class=\"u-text-left\"><span dir=\"auto\">\u56e2\u4f53<\/span><\/th>\n<th class=\"u-text-left\"><span dir=\"auto\">\u5904\u7406\u65b9\u6cd5<\/span><\/th>\n<th class=\"u-text-left\"><span dir=\"auto\">\u6cbb\u7597\u6548\u679c<\/span><\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td class=\"u-text-left\"><span dir=\"auto\">Packham \u7b49\u4eba (2016) [\u00a0<\/span><a id=\"ref-link-section-d156130925e3692\" title=\"Packham DK\u3001Fraser IR\u3001Kerr PG\u3001Segal KR\u3002\u5f02\u57fa\u56e0\u95f4\u5145\u8d28\u524d\u4f53\u7ec6\u80de(MPC) \u6cbb\u7597\u7cd6\u5c3f\u75c5\u80be\u75c5\uff1a\u4e00\u9879\u968f\u673a\u3001\u5b89\u6170\u5242\u5bf9\u7167\u3001\u5242\u91cf\u9012\u589e\u7814\u7a76\u3002 EBioMedicine\u3002 2016\uff1b12\uff1a263\u20139\u3002\" href=\"https:\/\/stemcellres.biomedcentral.com\/articles\/10.1186\/s13287-025-04750-3#ref-CR125\" data-track=\"click\" data-track-action=\"reference anchor\" data-track-label=\"link\" data-test=\"citation-ref\" aria-label=\"\u53c2\u8003\u6587\u732e125\" rel=\"nofollow noopener\" target=\"_blank\"><span dir=\"auto\">125<\/span><\/a><span dir=\"auto\">\u00a0]<\/span><\/td>\n<td class=\"u-text-left\"><span dir=\"auto\">\u60a3\u6709\u7cd6\u5c3f\u75c5\u80be\u75c5\u7684\u6210\u5e74\u4eba\uff08<\/span><i><span dir=\"auto\">n<\/span><\/i><span dir=\"auto\">\u00a0\u2009= 30\uff09<\/span><\/td>\n<td class=\"u-text-left\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u591a\u4e2d\u5fc3\u3001\u968f\u673a\u3001\u53cc\u76f2\u3001\u5242\u91cf\u9012\u589e\u3001\u5e8f\u8d2f\u3001\u5b89\u6170\u5242\u5bf9\u7167\u8bd5\u9a8c<\/span><\/span><\/span><\/td>\n<td class=\"u-text-left\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6210\u4eba\u540c\u79cd\u5f02\u4f53\u9aa8\u9ad3\u6765\u6e90\u95f4\u5145\u8d28\u524d\u4f53\u7ec6\u80de<\/span><\/span><\/span><\/p>\n<p><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7ec6\u80de\uff08MPC\uff09<\/span><\/span><\/span><\/td>\n<td class=\"u-text-left\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">T1\uff1a\u7528MPC 150 \u00d7 10\u00a0 <\/span><\/span><\/span><sup><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">6<\/span><\/span><\/span><\/sup><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5904\u7406\uff08<\/span><\/span><\/span><i><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">n<\/span><\/span><\/span><\/i><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u00a0\u2009= 10\uff09<\/span><\/span><\/span><\/p>\n<p><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">T2\uff1a\u7528MPC 300 \u00d7 10\u00a0 <\/span><\/span><\/span><sup><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">6<\/span><\/span><\/span><\/sup><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5904\u7406\uff08<\/span><\/span><\/span><i><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">n<\/span><\/span><\/span><\/i><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u00a0\u2009= 10\uff09<\/span><\/span><\/span><\/p>\n<p><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">C\uff1a\u5b89\u6170\u5242\u7ec4\uff08<\/span><\/span><\/span><i><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">n<\/span><\/span><\/span><\/i><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u00a0\u2009= 10\uff09<\/span><\/span><\/span><\/td>\n<td class=\"u-text-left\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u968f\u673a\u5206\u7ec4\u63a5\u53d7\u9759\u8109\u8f93\u6ce8MPC\uff08150 \u00d7 10\u2076<\/span><\/span><\/span><sup><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6216<\/span><\/span><\/span><\/sup><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">300 \u00d7 10\u2076<\/span><\/span><\/span><sup><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e2a<\/span><\/span><\/span><\/sup><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7ec6\u80de\uff09\u6216\u5b89\u6170\u5242<\/span><\/span><\/span><\/td>\n<td class=\"u-text-left\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">MPC\u6cbb\u7597\u53ef\u4ee5\u964d\u4f4eIL-6\u6c34\u5e73\uff0c\u7a33\u5b9a\u6216\u6539\u5584eGFR\u548cmGFR\u3002<\/span><\/span><\/span><\/td>\n<\/tr>\n<tr>\n<td class=\"u-text-left\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">Perico \u7b49\u4eba(2023) [\u00a0 <\/span><\/span><\/span><a id=\"ref-link-section-d156130925e3766\" title=\"Perico N\u3001Remuzzi G\u3001Griffin MD\u3001Cockwell P\u3001Maxwell AP\u3001Casiraghi F \u7b49\u3002\u95f4\u5145\u8d28\u57fa\u8d28\u7ec6\u80de(ORBCEL-M) \u7597\u6cd5\u6cbb\u7597\u7cd6\u5c3f\u75c5\u80be\u75c5\u7684\u5b89\u5168\u6027\u548c\u521d\u6b65\u7597\u6548\uff1a\u4e00\u9879\u968f\u673a\u4e34\u5e8a\u8bd5\u9a8c(NEPHSTROM)\u3002 J Am Soc Nephrol. 2023;34(10):1733\u201351\u3002\" href=\"https:\/\/stemcellres.biomedcentral.com\/articles\/10.1186\/s13287-025-04750-3#ref-CR126\" data-track=\"click\" data-track-action=\"reference anchor\" data-track-label=\"link\" data-test=\"citation-ref\" aria-label=\"\u53c2\u8003\u6587\u732e126\" rel=\"nofollow noopener\" target=\"_blank\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">126<\/span><\/span><\/span><\/a><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u00a0]<\/span><\/span><\/span><\/td>\n<td class=\"u-text-left\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">2 \u578b\u7cd6\u5c3f\u75c5\u548c\u8fdb\u884c\u6027DKD \u60a3\u8005\uff08<\/span><\/span><\/span><i><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">n<\/span><\/span><\/span><\/i><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u00a0\u2009= 16\uff09<\/span><\/span><\/span><\/td>\n<td class=\"u-text-left\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u76841b\/2a \u671f\u8bd5\u9a8c<\/span><\/span><\/span><\/td>\n<td class=\"u-text-left\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e0b\u4e00\u4ee3\u4eba\u9aa8\u9ad3\u6765\u6e90\u7684\u6297CD362\u6297\u4f53\u7b5b\u9009\u7684\u540c\u79cd\u5f02\u4f53\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08ORBCEL-M\uff09<\/span><\/span><\/span><\/td>\n<td class=\"u-text-left\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">T\uff1a\u63a5\u53d7ORBCEL-M \u6cbb\u7597\uff0c\uff08<\/span><\/span><\/span><i><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">n<\/span><\/span><\/span><\/i><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u00a0\u2009= 12\uff09<\/span><\/span><\/span><\/p>\n<p><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">C\uff1a\u5b89\u6170\u5242\u7ec4\uff08<\/span><\/span><\/span><i><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">n<\/span><\/span><\/span><\/i><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u00a0\u2009= 4\uff09<\/span><\/span><\/span><\/td>\n<td class=\"u-text-left\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u53d7\u8bd5\u8005\u88ab\u968f\u673a\u5206\u914d\u63a5\u53d7\u5355\u6b21\u9759\u8109\u8f93\u6ce8ORBCEL-M\uff0880 \u00d7 10\u2076<\/span><\/span><\/span><sup><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e2a<\/span><\/span><\/span><\/sup><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7ec6\u80de\uff09\u6216\u5b89\u6170\u5242\uff0c\u5e76\u968f\u8bbf18 \u4e2a\u6708\u3002<\/span><\/span><\/span><\/td>\n<td class=\"u-text-left\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\uff0cMSC \u7597\u6cd5\u663e\u7740\u51cf\u7f13\u4e86eGFR \u4e0b\u964d\uff0c\u540c\u65f6\u4fdd\u7559\u4e86\u8c03\u8282\u6027T \u7ec6\u80de\uff0c\u51cf\u5c11\u4e86\u81ea\u7136\u6740\u4f24\u6027T \u7ec6\u80de\uff0c\u5e76\u7a33\u5b9a\u4e86\u708e\u75c7\u6027\u5355\u6838\u7ec6\u80de\u4e9a\u7fa4\u3002<\/span><\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">2023<\/span><\/span><span style=\"font-family: \u5b8b\u4f53;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5e74\uff0c\u7531<\/span><\/span><\/span><span style=\"font-family: \u5b8b\u4f53;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7231\u5c14\u5170\u6208\u5c14\u97e6\u5927\u5b66<\/span><\/span><\/span><span style=\"font-family: \u5b8b\u4f53;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7275\u5934\uff0c\u8054\u5408<\/span><\/span><\/span><span style=\"font-family: \u5b8b\u4f53;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u82f1\u56fd\u4f2f\u660e\u7ff0\u5927\u5b66<\/span><\/span><\/span><span style=\"font-family: \u5b8b\u4f53;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e0e<\/span><\/span><\/span><span style=\"font-family: \u5b8b\u4f53;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u610f\u5927\u5229\u8d1d\u52a0\u83ab\u6559\u7687\u82e5\u671b\u4e8c\u5341\u4e09\u4e16\u533b\u9662<\/span><\/span><\/span><span style=\"font-family: \u5b8b\u4f53;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5f00\u5c55\u3002<\/span><\/span><\/span><span style=\"font-family: \u5b8b\u4f53;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5171\u7eb3\u5165<\/span><\/span><\/span><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">16\u00a0<\/span><\/span><span style=\"font-family: \u5b8b\u4f53;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4f4d\u00a0<\/span><\/span><\/span><span style=\"font-family: Calibri;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">2\u00a0<\/span><\/span><\/span><span style=\"font-family: \u5b8b\u4f53;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u578b\u7cd6\u5c3f\u75c5\u80be\u75c5\u60a3\u8005<\/span><\/span><\/span><span style=\"font-family: \u5b8b\u4f53;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff0c\u968f\u673a\u63a5\u53d7<\/span><\/span><\/span><span style=\"font-family: \u5b8b\u4f53;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5355\u6b21\u9759\u8109\u8f93\u6ce8<\/span><\/span><\/span><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u00a080\u00d710\u2076\u00a0<\/span><\/span><span style=\"font-family: \u5b8b\u4f53;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u9aa8\u9ad3\u6765\u6e90\u00a0<\/span><\/span><\/span><span style=\"font-family: Calibri;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">MSC<\/span><\/span><\/span>\u00a0<span style=\"font-family: \u5b8b\u4f53;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6216\u5b89\u6170\u5242\uff0c\u5e76\u968f\u8bbf<\/span><\/span><\/span><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">18\u00a0<\/span><\/span><span style=\"font-family: \u5b8b\u4f53;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e2a\u6708<\/span><\/span><\/span><span style=\"font-family: \u5b8b\u4f53;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u3002<\/span><\/span><\/span><\/p>\n<p><span style=\"font-family: \u5b8b\u4f53;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7ed3\u679c\u663e\u793a\uff1a\u5e72\u7ec6\u80de\u7ec4\u60a3\u8005\u7684<\/span><\/span><\/span><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">eGFR\u00a0<\/span><\/span><span style=\"font-family: \u5b8b\u4f53;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e0b\u964d\u901f\u5ea6\u663e\u7740\u51cf\u7f13<\/span><\/span><\/span><span style=\"font-family: \u5b8b\u4f53;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff0c\u66f2\u7ebf\u4ece\u9661\u5ced\u53d8\u5e73\u7f13\uff1b\u708e\u75c7\u4fe1\u53f7\u4e0b\u964d\u3001\u4fee\u590d\u4fe1\u53f7\u4e0a\u5347<\/span><\/span><\/span><span style=\"font-family: \u5b8b\u4f53;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff0c<\/span><\/span><\/span><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> Treg\u00a0<\/span><\/span><span style=\"font-family: \u5b8b\u4f53;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7a33\u5b9a\u3001<\/span><\/span><\/span><span style=\"font-family: Calibri;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">NKT\u00a0<\/span><\/span><\/span><span style=\"font-family: \u5b8b\u4f53;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e0b\u964d\uff0c\u514d\u75ab\u73af\u5883<\/span><\/span><\/span><span style=\"font-family: Calibri;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u201c<\/span><\/span><\/span><span style=\"font-family: \u5b8b\u4f53;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4ece\u635f\u4f24\u8f6c\u5411\u4fee\u590d<\/span><\/span><\/span><span style=\"font-family: Calibri;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u201d <\/span><\/span><\/span><span style=\"font-family: \u5b8b\u4f53;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff1b\u5b89\u5168\u6027\u65b9\u9762<\/span><\/span><\/span><span style=\"font-family: \u5b8b\u4f53;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff0c\u4ec5\u89c1\u5c11\u6570\u8f7b\u5fae\u8f93\u6ce8\u53cd\u5e94\uff0c\u65e0\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\u3002<\/span><\/span><\/span><span style=\"font-family: \u5b8b\u4f53;\"><br \/>\n<\/span><\/p>\n<p><span style=\"font-family: \u5b8b\u4f53;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e00\u53e5\u8bdd\u603b\u7ed3\uff1a\u4e00\u6b21<\/span><\/span><\/span><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u00a080\u00d710\u2076 MSC\u00a0<\/span><\/span><span style=\"font-family: \u5b8b\u4f53;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8f93\u6ce8\uff0c\u8ba9\u7cd6\u80be\u60a3\u8005\u7684\u80be\u529f\u80fd<\/span><\/span><\/span><span style=\"font-family: Calibri;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u201c<\/span><\/span><\/span><span style=\"font-family: \u5b8b\u4f53;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6162\u4e0b\u6765<\/span><\/span><\/span><span style=\"font-family: Calibri;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u201d <\/span><\/span><\/span><span style=\"font-family: \u5b8b\u4f53;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff0c\u5e76\u5728\u5b89\u5168\u6027\u4e0a\u8868\u73b0\u7a33\u5b9a\u53ef\u63a7\u3002<\/span><\/span><\/span><\/p>\n<section>\n<div id=\"attachment_20467\" style=\"width: 874px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-20467\" class=\"wp-image-20467 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-13_144051_038.png\" alt=\"\" width=\"864\" height=\"494\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-13_144051_038.png 864w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-13_144051_038-300x172.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-13_144051_038-768x439.png 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-13_144051_038-18x10.png 18w\" sizes=\"(max-width: 864px) 100vw, 864px\" \/><p id=\"caption-attachment-20467\" class=\"wp-caption-text\">\u95f4\u5145\u8d28\u57fa\u8d28\u7ec6\u80de\uff08ORBCEL-M\uff09\u7597\u6cd5\u6cbb\u7597\u7cd6\u5c3f\u75c5\u80be\u75c5\u7684\u5b89\u5168\u6027\u548c\u521d\u6b65\u7597\u6548\uff1a\u4e00\u9879\u968f\u673a\u4e34\u5e8a\u8bd5\u9a8c\uff08NEPHSTROM\uff09<\/p><\/div>\n<\/section>\n<h2><span class=\"ez-toc-section\" id=\"03%E3%80%81%E8%83%BD%E5%92%8C%E8%8D%AF%E7%89%A9%E5%B9%B6%E7%94%A8%E5%90%97%EF%BC%9F\"><\/span><span style=\"font-family: \u5b8b\u4f53;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">03\u3001\u80fd\u548c\u836f\u7269\u5e76\u7528\u5417\uff1f<\/span><\/span><\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"font-family: \u5b8b\u4f53;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5b8c\u5168\u53ef\u4ee5\u3002<\/span><\/span><\/span><\/p>\n<p><span style=\"font-family: \u5b8b\u4f53;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u591a\u9879\u7814\u7a76\u663e\u793a\uff0c\u5e72\u7ec6\u80de\u4e0e<\/span><\/span><\/span><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">SGLT2\u00a0<\/span><\/span><span style=\"font-family: \u5b8b\u4f53;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6291\u5236\u5242\u3001<\/span><\/span><\/span><span style=\"font-family: Calibri;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">GLP-1RA <\/span><\/span><\/span><span style=\"font-family: \u5b8b\u4f53;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u3001<\/span><\/span><\/span><span style=\"font-family: Calibri;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">ARB<\/span><\/span><\/span>\u00a0<span style=\"font-family: \u5b8b\u4f53;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7b49\u836f\u7269\u8054\u7528\u65f6\uff0c\u5728\u52a8\u7269\u5b9e\u9a8c\u4e0e\u65e9\u671f\u4e34\u5e8a\u4e2d\u5448\u73b0\u51fa\u534f\u540c\u6548\u679c\uff1a\u4ee3\u8c22\u51cf\u8d1f<\/span><\/span><\/span><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u00a0+\u00a0<\/span><\/span><span style=\"font-family: \u5b8b\u4f53;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u708e\u75c7\u6291\u5236\u00a0<\/span><\/span><\/span><span style=\"font-family: Calibri;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">+\u00a0<\/span><\/span><\/span><span style=\"font-family: \u5b8b\u4f53;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7ed3\u6784\u4fee\u590d<\/span><\/span><\/span><span style=\"font-family: \u5b8b\u4f53;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff0c\u8ba9\u6cbb\u7597\u66f4\u7cfb\u7edf\u3001\u66f4\u6301\u4e45\u3002<\/span><\/span><\/span><\/p>\n<p><span style=\"font-family: \u5b8b\u4f53;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u76ee\u524d\u591a\u6570\u7814\u7a76\u91c7\u7528<\/span><\/span><\/span><span style=\"font-family: \u5b8b\u4f53;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5355\u6b21\u9759\u8109\u8f93\u6ce8\u65b9\u6848<\/span><\/span><\/span><span style=\"font-family: \u5b8b\u4f53;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff0c\u7597\u7a0b\u540e<\/span><\/span><\/span><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u00a03\u20136\u00a0<\/span><\/span><span style=\"font-family: \u5b8b\u4f53;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e2a\u6708\u590d\u67e5\u80be\u529f\u80fd\u4e0e\u86cb\u767d\u5c3f\u53d8\u5316\u3002<\/span><\/span><\/span><\/p>\n<section><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-20477 aligncenter\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5fae\u4fe1\u56fe\u7247_2025-11-13_174915_846.png\" alt=\"\" width=\"1055\" height=\"702\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5fae\u4fe1\u56fe\u7247_2025-11-13_174915_846.png 1055w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5fae\u4fe1\u56fe\u7247_2025-11-13_174915_846-300x200.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5fae\u4fe1\u56fe\u7247_2025-11-13_174915_846-1024x681.png 1024w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5fae\u4fe1\u56fe\u7247_2025-11-13_174915_846-768x511.png 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5fae\u4fe1\u56fe\u7247_2025-11-13_174915_846-18x12.png 18w\" sizes=\"(max-width: 1055px) 100vw, 1055px\" \/><\/section>\n<h2><span class=\"ez-toc-section\" id=\"04%E3%80%81%E8%B0%81%E5%8F%AF%E8%83%BD%E6%9B%B4%E9%80%82%E5%90%88%E8%80%83%E8%99%91%EF%BC%9F\"><\/span><span style=\"font-family: \u5b8b\u4f53;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">04\u3001\u8c01\u53ef\u80fd\u66f4\u9002\u5408\u8003\u8651\uff1f<\/span><\/span><\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"font-family: Calibri;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u2714\u00a0<\/span><\/span><\/span><span style=\"font-family: \u5b8b\u4f53;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5df2\u786e\u8bca\u7cd6\u5c3f\u75c5\u80be\u75c5\uff1b<\/span><\/span><\/span><br \/>\n<span style=\"font-family: Calibri;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u2714\u00a0<\/span><\/span><\/span><span style=\"font-family: \u5b8b\u4f53;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4f7f\u7528\u89c4\u8303\u836f\u7269\u540e\uff0c\u80be\u529f\u80fd\u4ecd\u5728\u6301\u7eed\u4e0b\u964d\uff1b<\/span><\/span><\/span><br \/>\n<span style=\"font-family: Calibri;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u2714\u00a0<\/span><\/span><\/span><span style=\"font-family: \u5b8b\u4f53;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u60f3\u5728\u5b89\u5168\u3001\u5408\u89c4\u7684\u6761\u4ef6\u4e0b\u5c1d\u8bd5\u65b0\u6cbb\u7597\u3002<\/span><\/span><\/span><\/p>\n<p><span style=\"font-family: \u5b8b\u4f53;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c\u76ee\u524d\u56fd\u5185\u4e5f\u6709\u591a\u5bb6\u4e09\u7532\u533b\u9662\u5df2\u542f\u52a8\u5e72\u7ec6\u80de\u6cbb\u7597\u7cd6\u80be\u7684\u4e34\u5e8a\u9879\u76ee\u3002\u7b26\u5408\u6761\u4ef6\u7684\u60a3\u8005\u53ef\u5728\u533b\u751f\u6307\u5bfc\u4e0b\u8fdb\u884c\u8bc4\u4f30\u5165\u7ec4\u3002<\/span><\/span><\/span><\/p>\n<h2><span class=\"ez-toc-section\" id=\"05%E3%80%81%E7%BB%93%E8%AE%BA%E4%B8%8E%E5%B1%95%E6%9C%9B\"><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">05\u3001\u7ed3\u8bba\u4e0e\u5c55\u671b<\/span><\/span><\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u672c\u7efc\u8ff0\u6982\u8ff0\u4e86\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09\u6cbb\u7597\u7cd6\u5c3f\u75c5\u80be\u75c5\uff08DKD\uff09\u7684\u673a\u5236\uff0c\u5305\u62ec\u6291\u5236\u708e\u75c7\u3001\u7ea4\u7ef4\u5316\u3001\u6c27\u5316\u5e94\u6fc0\u3001\u7ec6\u80de\u51cb\u4ea1\u3001\u94c1\u6b7b\u4ea1\u548c\u7ec6\u80de\u7126\u4ea1\uff0c\u4ee5\u53ca\u4fc3\u8fdb\u81ea\u566c\u3001\u7ebf\u7c92\u4f53\u8f6c\u79fb\u548cVEGF\u9776\u5411\u4f5c\u7528\u3002<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e34\u5e8a\u8bd5\u9a8c\u8868\u660e\uff0c\u57fa\u4e8e\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6cbb\u7597\u7cd6\u5c3f\u75c5\u80be\u75c5\u901a\u5e38\u5b89\u5168\u4e14\u8010\u53d7\u6027\u826f\u597d\uff0c\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\u7f55\u89c1\u3002\u4e3a\u4e86\u6e05\u6670\u6982\u8ff0\u5f53\u524d\u7684\u7814\u7a76\u73b0\u72b6\uff0c\u6211\u4eec\u5c06\u5173\u952e\u673a\u5236\u548c\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u6c47\u603b\u4e8e\u4e24\u5f20\u8868\u683c\uff08\u88681\u548c\u88682\uff09\u548c\u4e09\u5f20\u56fe\u8868\uff08\u56fe1\u3001\u56fe2\u548c\u56fe3\uff09\u4e2d\uff0c\u4ee5\u5e2e\u52a9\u8bfb\u8005\u66f4\u597d\u5730\u4e86\u89e3\u6700\u65b0\u8fdb\u5c55\u3002<\/span><\/span><\/p>\n<section>\n<div id=\"attachment_20466\" style=\"width: 2018px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-20466\" class=\"wp-image-20466 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5fae\u4fe1\u56fe\u7247_2025-11-13_150636_484.png\" alt=\"\" width=\"2008\" height=\"2008\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5fae\u4fe1\u56fe\u7247_2025-11-13_150636_484.png 2008w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5fae\u4fe1\u56fe\u7247_2025-11-13_150636_484-300x300.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5fae\u4fe1\u56fe\u7247_2025-11-13_150636_484-1024x1024.png 1024w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5fae\u4fe1\u56fe\u7247_2025-11-13_150636_484-150x150.png 150w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5fae\u4fe1\u56fe\u7247_2025-11-13_150636_484-768x768.png 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5fae\u4fe1\u56fe\u7247_2025-11-13_150636_484-1536x1536.png 1536w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5fae\u4fe1\u56fe\u7247_2025-11-13_150636_484-12x12.png 12w\" sizes=\"(max-width: 2008px) 100vw, 2008px\" \/><p id=\"caption-attachment-20466\" class=\"wp-caption-text\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u56fe3\uff1a\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6cbb\u7597\u7cd6\u5c3f\u75c5\u80be\u75c5\u673a\u5236\u6982\u8ff0\u3002<\/span><\/span><\/p><\/div>\n<\/section>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7136\u800c\uff0c\u6311\u6218\u4f9d\u7136\u5b58\u5728\uff1aMSCs\u7684\u5f02\u8d28\u6027\u3001\u79fb\u690d\u540e\u7684\u5b58\u6d3b\u4e0e\u529f\u80fd\u7a33\u5b9a\u6027\u3001\u957f\u671f\u5b89\u5168\u6027\u4ee5\u53ca\u5927\u89c4\u6a21\u751f\u4ea7\u5de5\u827a\u7b49\u95ee\u9898\uff0c\u5747\u662f\u5b9e\u73b0\u5e7f\u6cdb\u4e34\u5e8a\u5e94\u7528\u7684\u74f6\u9888\u3002\u672a\u6765\u7814\u7a76\u5e94\u81f4\u529b\u4e8e\u4f18\u5316\u7ec6\u80de\u5236\u5907\u5de5\u827a\u3001\u5f00\u53d1\u65b0\u578b\u9012\u9001\u7cfb\u7edf\u3001\u7ed3\u5408\u57fa\u56e0\u7f16\u8f91\u6280\u672f\uff0c\u5e76\u901a\u8fc7\u8bbe\u8ba1\u4e25\u8c28\u7684\u5927\u89c4\u6a21\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u6700\u7ec8\u5c06\u8fd9\u4e00\u524d\u6cbf\u79d1\u6280\u8f6c\u5316\u4e3a\u60e0\u53ca\u5e7f\u5927DKD\u60a3\u8005\u7684\u5207\u5b9e\u7597\u6cd5\u3002<\/span><\/span><\/p>\n<\/section>\n<\/section>\n<blockquote><p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u53c2\u8003\u8d44\u6599\uff1a<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">[1] <\/span><\/span><span data-pm-slice=\"0 0 []\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">Zheng, L., Chen, W., Yao, K.\u00a0<\/span><\/span><\/span><i><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7b49.<\/span><\/span><\/i><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u00a0\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6cbb\u7597\u7cd6\u5c3f\u75c5\u80be\u75c5\u7684\u673a\u5236.\u00a0<\/span><\/span><i><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5e72\u7ec6\u80de\u7814\u7a76\u4e0e\u6cbb\u7597<\/span><\/span><\/i>\u00a0<b><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">16<\/span><\/span><\/b><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> , 629 (2025). https:\/\/doi.org\/10.1186\/s13287-025-04750-3<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u514d\u8d23\u8bf4\u660e\uff1a\u672c\u6587\u4ec5\u7528\u4e8e\u4f20\u64ad\u79d1\u666e\u77e5\u8bc6\uff0c\u5206\u4eab\u884c\u4e1a\u89c2\u70b9\uff0c\u4e0d\u6784\u6210\u4efb\u4f55\u4e34\u5e8a\u8bca\u65ad\u5efa\u8bae\uff01\u676d\u5409\u5e72\u7ec6\u80de\u6240\u53d1\u5e03\u7684\u4fe1\u606f\u4e0d\u80fd\u66ff\u4ee3\u533b\u751f\u6216\u836f\u5242\u5e08\u7684\u4e13\u4e1a\u5efa\u8bae\u3002\u5982\u6709\u7248\u6743\u7b49\u7591\u95ee\uff0c\u8bf7\u968f\u65f6\u8054\u7cfb\u6211\u3002<\/span><\/span><\/p><\/blockquote>","protected":false},"excerpt":{"rendered":"<p>\u7cd6\u5c3f\u75c5\u80be\u75c5\uff08DKD\uff09\u662f\u7cd6\u5c3f\u75c5\u7684\u4e00\u79cd\u4e25\u91cd\u5fae\u8840\u7ba1\u5e76\u53d1\u75c7\uff0c\u5176\u75c7\u72b6\u5305\u62ec\u8fdb\u884c\u6027\u80be\u529f\u80fd\u969c\u788d\u3001\u86cb\u767d\u5c3f\u548c\u7ea4\u7ef4\u5316\uff0c\u6700\u7ec8\u53d1\u5c55\u4e3a\u7ec8\u672b [&hellip;]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[76],"tags":[150,227,226],"_links":{"self":[{"href":"https:\/\/www.hjtdsm.cn\/ar\/wp-json\/wp\/v2\/posts\/20463"}],"collection":[{"href":"https:\/\/www.hjtdsm.cn\/ar\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hjtdsm.cn\/ar\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/ar\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/ar\/wp-json\/wp\/v2\/comments?post=20463"}],"version-history":[{"count":1,"href":"https:\/\/www.hjtdsm.cn\/ar\/wp-json\/wp\/v2\/posts\/20463\/revisions"}],"predecessor-version":[{"id":20478,"href":"https:\/\/www.hjtdsm.cn\/ar\/wp-json\/wp\/v2\/posts\/20463\/revisions\/20478"}],"wp:attachment":[{"href":"https:\/\/www.hjtdsm.cn\/ar\/wp-json\/wp\/v2\/media?parent=20463"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/ar\/wp-json\/wp\/v2\/categories?post=20463"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/ar\/wp-json\/wp\/v2\/tags?post=20463"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}