{"id":20491,"date":"2025-11-17T16:38:58","date_gmt":"2025-11-17T08:38:58","guid":{"rendered":"https:\/\/www.hjtdsm.cn\/?p=20491"},"modified":"2025-11-17T16:38:58","modified_gmt":"2025-11-17T08:38:58","slug":"%e5%b9%b2%e7%bb%86%e8%83%9e%e6%b2%bb%e7%96%97%e5%b8%95%e9%87%91%e6%a3%ae%e7%97%85","status":"publish","type":"post","link":"https:\/\/www.hjtdsm.cn\/ar\/stem-cells\/stem-cell-therapy\/20491.html","title":{"rendered":"\u5e72\u7ec6\u80de\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\u7684\u65b0\u8def\u5f84\uff1a\u5e72\u7ec6\u80de\u4fee\u590d\u591a\u5df4\u80fa\u795e\u7ecf\u5143\uff0bBDNF\u63d0\u4f9b\u795e\u7ecf\u4fdd\u62a4\u7684\u53cc\u91cd\u5e72\u9884"},"content":{"rendered":"<section data-role=\"list\">\n<section data-role=\"list\" data-pm-slice=\"4 4 [&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;outer&quot;,&quot;label&quot;:&quot;edit by 135editor&quot;,&quot;data-pm-slice&quot;:&quot;0 0 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>\u5e72\u7ec6\u80de\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\u7684\u65b0\u8def\u5f84\uff1a\u5e72\u7ec6\u80de\u4fee\u590d\u591a\u5df4\u80fa\u795e\u7ecf\u5143\uff0bBDNF\u63d0\u4f9b\u795e\u7ecf\u4fdd\u62a4\u7684\u53cc\u91cd\u5e72\u9884<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.hjtdsm.cn\/ar\/stem-cells\/stem-cell-therapy\/20491.html\/#%E7%9B%AE%E5%89%8D%E5%B8%95%E9%87%91%E6%A3%AE%E7%97%85%E7%9A%84%E6%B2%BB%E7%96%97%E6%96%B9%E6%B3%95\" >\u76ee\u524d\u5e15\u91d1\u68ee\u75c5\u7684\u6cbb\u7597\u65b9\u6cd5<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.hjtdsm.cn\/ar\/stem-cells\/stem-cell-therapy\/20491.html\/#%E5%B9%B2%E7%BB%86%E8%83%9E%E6%9B%BF%E4%BB%A3%E7%96%97%E6%B3%95%E6%B2%BB%E7%96%97%E5%B8%95%E9%87%91%E6%A3%AE%E7%97%85%E7%9A%84%E6%9C%BA%E5%88%B6%E3%80%81%E4%BC%98%E5%8A%BF%E5%8F%8A%E5%8F%AF%E8%A1%8C%E6%80%A7\" 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class=\"size-full wp-image-20498 aligncenter\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-14_112226_629.png\" alt=\"\" width=\"736\" height=\"414\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-14_112226_629.png 736w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-14_112226_629-300x169.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-14_112226_629-18x10.png 18w\" sizes=\"(max-width: 736px) 100vw, 736px\" \/><\/section>\n<p>\u8fd1\u671f\u53d1\u8868\u4e8e\u300a\u4e2d\u56fd\u795e\u7ecf\u5916\u79d1\u6742\u5fd7\u300b\u7684\u4e00\u7bc7<a href=\"https:\/\/cnjournal.biomedcentral.com\/articles\/10.1186\/s41016-025-00415-5\" target=\"_blank\" rel=\"noopener 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id=\"%E7%9B%AE%E5%89%8D%E5%B8%95%E9%87%91%E6%A3%AE%E7%97%85%E7%9A%84%E6%B2%BB%E7%96%97%E6%96%B9%E6%B3%95\"><\/span><strong>\u76ee\u524d\u5e15\u91d1\u68ee\u75c5\u7684\u6cbb\u7597\u65b9\u6cd5<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>\u76ee\u524d\u5e15\u91d1\u68ee\u75c5\u7684\u6cbb\u7597\u4e3b\u8981\u4ecd\u4ee5\u5bf9\u75c7\u6cbb\u7597\u4e3a\u4e3b\uff0c\u901a\u5e38\u9700\u8981\u591a\u79cd\u836f\u7269\u8054\u5408\u6cbb\u7597\uff0c\u4e14\u526f\u4f5c\u7528\u663e\u8457\u3002\u8fd9\u4e9b\u7597\u6cd5\u4ec5\u9488\u5bf9\u75c7\u72b6\uff0c\u800c\u672a\u9488\u5bf9\u6f5c\u5728\u7684\u795e\u7ecf\u5143\u9000\u884c\u6027\u75c5\u53d8\u3002<\/p>\n<ul class=\"list-paddingleft-1\">\n<li><a href=\"https:\/\/www.hjtdsm.cn\/ar\/research\/ns\/pd\/20370.html\/\" target=\"_blank\" rel=\"noopener\">\u6b63\u5728\u5f00\u53d1\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\u7684\u65b9\u6cd5\uff1a\u5e72\u7ec6\u80de\u3001\u57fa\u56e0\u7597\u6cd5\u4e0e\u65b0\u836f\u5982\u4f55\u91cd\u5851\u672a\u6765<\/a><\/li>\n<\/ul>\n<p>\u5e15\u91d1\u68ee\u75c5\u76ee\u524d\u7684\u6cbb\u7597\u65b9\u6cd5\u65e8\u5728\u901a\u8fc7\u836f\u7269\u3001\u5668\u68b0\u8f85\u52a9\u548c\u624b\u672f\u7b56\u7565\u6765\u7f13\u89e3\u8fd0\u52a8\u75c7\u72b6\u3001\u5ef6\u7f13\u75be\u75c5\u8fdb\u5c55\u5e76\u63d0\u9ad8\u60a3\u8005\u7684\u751f\u6d3b\u8d28\u91cf\u3002\u8fd9\u4e9b\u7597\u6cd5\u4e3b\u8981\u9488\u5bf9\u591a\u5df4\u80fa\u7f3a\u4e4f\u548c\u5f02\u5e38\u86cb\u767d\u79ef\u7d2f\uff0c\u6cbb\u7597\u65b9\u6cd5\u6db5\u76d6\u4e86\u4ece\u4f20\u7edf\u7684\u5de6\u65cb\u591a\u5df4\u65b9\u6848\u5230\u5148\u8fdb\u7684\u795e\u7ecf\u8c03\u63a7\u548c\u6301\u7eed\u7ed9\u836f\u7cfb\u7edf\u7b49\u591a\u79cd\u9014\u5f84\u3002<\/p>\n<p>\u88681\u5bf9\u8fd9\u4e9b\u6cbb\u7597\u65b9\u5f0f\u8fdb\u884c\u4e86\u5168\u9762\u7684\u603b\u7ed3\uff0c\u5305\u62ec\u5176\u4f5c\u7528\u673a\u5236\u3001\u4f18\u52bf\u548c\u5c40\u9650\u6027\u3002<\/p>\n<section>\n<div id=\"attachment_20497\" style=\"width: 1142px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-20497\" class=\"wp-image-20497 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-14_112300_011.png\" alt=\"\" width=\"1132\" height=\"377\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-14_112300_011.png 1132w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-14_112300_011-300x100.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-14_112300_011-1024x341.png 1024w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-14_112300_011-768x256.png 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-14_112300_011-18x6.png 18w\" sizes=\"(max-width: 1132px) 100vw, 1132px\" \/><p id=\"caption-attachment-20497\" class=\"wp-caption-text\">\u88681\uff1a\u5e15\u91d1\u68ee\u75c5\u76ee\u524d\u7684\u6cbb\u7597\u7b56\u7565<\/p><\/div>\n<\/section>\n<p>\u5982\u88681\u6240\u793a 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class=\"ez-toc-section\" id=\"%E5%B9%B2%E7%BB%86%E8%83%9E%E6%9B%BF%E4%BB%A3%E7%96%97%E6%B3%95%E6%B2%BB%E7%96%97%E5%B8%95%E9%87%91%E6%A3%AE%E7%97%85%E7%9A%84%E6%9C%BA%E5%88%B6%E3%80%81%E4%BC%98%E5%8A%BF%E5%8F%8A%E5%8F%AF%E8%A1%8C%E6%80%A7\"><\/span><strong>\u5e72\u7ec6\u80de\u66ff\u4ee3\u7597\u6cd5\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\u7684\u673a\u5236\u3001\u4f18\u52bf\u53ca\u53ef\u884c\u6027<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>\u5e72\u7ec6\u80de\u66ff\u4ee3\u7597\u6cd5\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\u7684\u673a\u5236\u4e3b\u8981\u6d89\u53ca\u901a\u8fc7\u5e72\u7ec6\u80de\u5206\u5316\u4e3a\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u6765\u66ff\u4ee3\u56e0\u75be\u75c5\u9000\u5316\u800c\u4e22\u5931\u7684\u7ec6\u80de\uff0c\u4ece\u800c\u6062\u590d\u5927\u8111\u4e2d\u7684<span class=\"\">\u591a\u5df4\u80fa\u6c34\u5e73<\/span>\u3002\u5177\u4f53\u800c\u8a00\uff0c\u8be5\u7597\u6cd5\u901a\u8fc7\u76f4\u63a5\u4fee\u590d\u9014\u5f84\uff0c\u5982\u5c06\u4eba\u7c7b\u591a\u80fd\u5e72\u7ec6\u80de\uff08hPSCs\uff09\u6216\u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de\uff08iPSCs\uff09\u5206\u5316\u4e3a\u4e2d\u8111\u591a\u5df4\u80fa\u80fd\u7956\u7ec6\u80de\uff08mDAPs\uff09\uff0c\u79fb\u690d\u540e\u8fd9\u4e9b\u7ec6\u80de\u80fd\u591f\u6574\u5408\u5230\u5bbf\u4e3b\u795e\u7ecf\u56de\u8def\u4e2d\uff0c\u751f\u7406\u6027\u5730\u91ca\u653e\u591a\u5df4\u80fa\uff0c\u5e76\u4fc3\u8fdb\u7eb9\u72b6\u4f53\u518d\u652f\u914d\u548c\u795e\u7ecf\u56de\u8def\u4fee\u590d\u3002<\/p>\n<section><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-20492 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-14_121558_220.png\" alt=\"\u5e72\u7ec6\u80de\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\u7684\u65b0\u8def\u5f84\uff1a\u5e72\u7ec6\u80de\u4fee\u590d\u591a\u5df4\u80fa\u795e\u7ecf\u5143\uff0bBDNF\u63d0\u4f9b\u795e\u7ecf\u4fdd\u62a4\u7684\u53cc\u91cd\u5e72\u9884\" width=\"1013\" height=\"676\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-14_121558_220.png 1013w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-14_121558_220-300x200.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-14_121558_220-768x513.png 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-14_121558_220-18x12.png 18w\" sizes=\"(max-width: 1013px) 100vw, 1013px\" 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loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-20494 aligncenter\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-14_113624_453.png\" alt=\"\" width=\"772\" height=\"461\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-14_113624_453.png 772w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-14_113624_453-300x179.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-14_113624_453-768x459.png 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-14_113624_453-18x12.png 18w\" sizes=\"(max-width: 772px) 100vw, 772px\" \/><\/section>\n<p><span dir=\"auto\">\u5728\u4e00\u9879I\/II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0ciPSC\u884d\u751f\u7684\u591a\u5df4\u80fa\u80fd\u7956\u7ec6\u80de\u6210\u529f\u690d\u5165\uff0c\u91ca\u653e\u591a\u5df4\u80fa\uff0c\u4e14\u672a\u53d1\u751f\u80bf\u7624\u53d1\u751f\u3002<\/span><\/p>\n<p><span dir=\"auto\">\u540c\u6837\uff0c\u5728\u4e00\u9879I\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c<a class=\"normal_text_link mp_article_text_link\" href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzkwOTEzMDY0Nw==&amp;mid=2247515002&amp;idx=1&amp;sn=72dd641178778a5861a0e29dd73ea901&amp;scene=21#wechat_redirect\" target=\"_blank\" rel=\"noopener nofollow\" data-itemshowtype=\"0\" data-linktype=\"2\">\u4eba\u80da\u80ce\u5e72\u7ec6\u80de\uff08hESC\uff09\u884d\u751f\u7684\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u4e5f\u5b89\u5168\u79fb\u690d\uff0c\u6574\u5408\u5230\u5bbf\u4e3b\u795e\u7ecf\u56de\u8def\u4e2d\uff0c\u5e76\u4fc3\u8fdb\u4e86\u529f\u80fd\u6062\u590d<\/a>\u3002\u8fd9\u4e9b\u53d1\u73b0\u5f3a\u8c03\u4e86\u57fa\u4e8e\u5e72\u7ec6\u80de\u7684\u795e\u7ecf\u518d\u751f\u7b56\u7565\u5728\u5e15\u91d1\u68ee\u75c5\u6cbb\u7597\u4e2d\u7684\u53ef\u884c\u6027\u548c\u524d\u666f\u3002<\/span><\/p>\n<h2><span class=\"ez-toc-section\" id=\"BDNF%E5%9C%A8%E5%B8%95%E9%87%91%E6%A3%AE%E7%97%85%E4%B8%AD%E7%9A%84%E4%BD%9C%E7%94%A8%E5%92%8C%E6%B2%BB%E7%96%97%E6%BD%9C%E5%8A%9B%E6%98%AF%E4%BB%80%E4%B9%88%EF%BC%9F\"><\/span><strong>BDNF\u5728\u5e15\u91d1\u68ee\u75c5\u4e2d\u7684\u4f5c\u7528\u548c\u6cbb\u7597\u6f5c\u529b\u662f\u4ec0\u4e48\uff1f<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p data-spm-anchor-id=\"5176.28103460.0.i21.39367551ItdekH\" data-pm-slice=\"0 0 []\"><span data-pm-slice=\"1 1 [&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;outer&quot;,&quot;class&quot;:&quot;article135&quot;,&quot;label&quot;:&quot;edit by 135editor&quot;,&quot;data-pm-slice&quot;:&quot;0 0 []&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;paragraph&quot;,&quot;class&quot;:&quot;&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;list&quot;,&quot;class&quot;:&quot;&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;list&quot;,&quot;data-pm-slice&quot;:&quot;4 4 [\\&quot;para\\&quot;,{\\&quot;tagName\\&quot;:\\&quot;section\\&quot;,\\&quot;attributes\\&quot;:{\\&quot;data-role\\&quot;:\\&quot;outer\\&quot;,\\&quot;label\\&quot;:\\&quot;edit by 135editor\\&quot;,\\&quot;data-pm-slice\\&quot;:\\&quot;0 0 []\\&quot;},\\&quot;namespaceURI\\&quot;:\\&quot;http:\/\/www.w3.org\/1999\/xhtml\\&quot;},\\&quot;para\\&quot;,{\\&quot;tagName\\&quot;:\\&quot;section\\&quot;,\\&quot;attributes\\&quot;:{\\&quot;data-role\\&quot;:\\&quot;paragraph\\&quot;},\\&quot;namespaceURI\\&quot;:\\&quot;http:\/\/www.w3.org\/1999\/xhtml\\&quot;}]&quot;,&quot;class&quot;:&quot;&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;outer&quot;,&quot;class&quot;:&quot;article135&quot;,&quot;label&quot;:&quot;edit by 135editor&quot;,&quot;data-pm-slice&quot;:&quot;0 0 []&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;paragraph&quot;,&quot;class&quot;:&quot;&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;list&quot;,&quot;class&quot;:&quot;&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;list&quot;,&quot;data-pm-slice&quot;:&quot;4 4 [\\&quot;para\\&quot;,{\\&quot;tagName\\&quot;:\\&quot;section\\&quot;,\\&quot;attributes\\&quot;:{\\&quot;data-role\\&quot;:\\&quot;outer\\&quot;,\\&quot;label\\&quot;:\\&quot;edit by 135editor\\&quot;,\\&quot;data-pm-slice\\&quot;:\\&quot;0 0 []\\&quot;},\\&quot;namespaceURI\\&quot;:\\&quot;http:\/\/www.w3.org\/1999\/xhtml\\&quot;},\\&quot;para\\&quot;,{\\&quot;tagName\\&quot;:\\&quot;section\\&quot;,\\&quot;attributes\\&quot;:{\\&quot;data-role\\&quot;:\\&quot;paragraph\\&quot;},\\&quot;namespaceURI\\&quot;:\\&quot;http:\/\/www.w3.org\/1999\/xhtml\\&quot;}]&quot;,&quot;class&quot;:&quot;&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;p&quot;,&quot;attributes&quot;:{},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;node&quot;,{&quot;tagName&quot;:&quot;span&quot;,&quot;attributes&quot;:{&quot;style&quot;:&quot;font-size:15px;&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;}]\">\u5728\u4f5c\u7528\u673a\u5236\u65b9\u9762\uff0c<\/span>BDNF\u5728\u5e15\u91d1\u68ee\u75c5\u4e2d\u626e\u6f14\u7740\u5173\u952e\u7684\u795e\u7ecf\u4fdd\u62a4\u89d2\u8272\uff0c\u5b83\u901a\u8fc7\u4e0eTrkB\u53d7\u4f53\u7ed3\u5408\u6fc0\u6d3bPI3K\/Akt\u3001MAPK\/ERK\u548cPLC-\u03b3\u4fe1\u53f7\u901a\u8def\uff0c\u663e\u8457\u589e\u5f3a\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u7684\u5b58\u6d3b\u7387\u3001\u7a81\u89e6\u53ef\u5851\u6027\u548c\u6297\u51cb\u4ea1\u80fd\u529b\u3002\u7814\u7a76\u8868\u660e\uff0c\u5e15\u91d1\u68ee\u75c5\u60a3\u8005\u9ed1\u8d28\u548c\u7eb9\u72b6\u4f53\u4e2d\u7684BDNF\u6c34\u5e73\u663e\u8457\u964d\u4f4e\uff0c\u4e14\u4e0e\u8fd0\u52a8\u969c\u788d\u548c\u975e\u8fd0\u52a8\u75c7\u72b6\u5bc6\u5207\u76f8\u5173\u3002<\/p>\n<ul class=\"list-paddingleft-1\">\n<li>\n<p data-spm-anchor-id=\"5176.28103460.0.i21.39367551ItdekH\" data-pm-slice=\"0 0 []\">BDNF\u4e0d\u4ec5\u652f\u6301\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u7684\u5b58\u6d3b\uff0c\u8fd8\u80fd\u4fdd\u62a4\u9ed1\u8d28\u4e2dGABA\u80fd\u795e\u7ecf\u5143\u514d\u53d7\u5174\u594b\u6027\u6bd2\u6027\u635f\u4f24\uff0c\u5e76\u901a\u8fc7\u8c03\u8282\u591a\u5df4\u80fa\u53d7\u4f53\u548c\u916a\u6c28\u9178\u7f9f\u5316\u9176\u8868\u8fbe\u6765\u4f18\u5316\u591a\u5df4\u80fa\u4fe1\u53f7\u4f20\u5bfc\uff0c\u4e3a\u5e15\u91d1\u68ee\u75c5\u7684\u75c5\u7406\u673a\u5236\u63d0\u4f9b\u91cd\u8981\u9776\u70b9\u3002<\/p>\n<\/li>\n<\/ul>\n<p>BDNF\u7684\u6cbb\u7597\u6f5c\u529b\u4e3b\u8981\u4f53\u73b0\u5728\u5176\u591a\u7ef4\u795e\u7ecf\u4fdd\u62a4\u4f5c\u7528\u4e0a\uff0c\u4e34\u5e8a\u524d\u7814\u7a76\u663e\u793a\u5916\u6e90\u6027BDNF\u6216\u5185\u6e90\u6027BDNF\u4e0a\u8c03\u53ef\u51cf\u5c11\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u4e22\u5931\u5e76\u6539\u5584\u8fd0\u52a8\u529f\u80fd\u3002\u4e3a\u514b\u670dBDNF\u96be\u4ee5\u7a7f\u900f\u8840\u8111\u5c4f\u969c\u7684\u5c40\u9650\u6027\uff0c\u7814\u7a76\u4eba\u5458\u5f00\u53d1\u4e86\u57fa\u56e0\u5de5\u7a0b\u5316\u5e72\u7ec6\u80de\u7b56\u7565\u2014\u2014\u901a\u8fc7\u6162\u75c5\u6bd2\u8f7d\u4f53\u6216CRISPR\/Cas9\u6280\u672f\u5c06BDNF\u57fa\u56e0\u6574\u5408\u5230MSCs\u6216iPSCs\u4e2d\uff0c\u4f7f\u5176\u5728\u79fb\u690d\u540e\u6301\u7eed\u5206\u6cccBDNF\u3002<\/p>\n<ul class=\"list-paddingleft-1\">\n<li>\u8fd9\u79cd\u8054\u5408\u7b56\u7565\u4e0d\u4ec5\u80fd\u63d0\u4f9b\u7ed3\u6784\u4fee\u590d\uff08\u5e72\u7ec6\u80de\u5206\u5316\u4e3a\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\uff09\uff0c\u8fd8\u80fd\u63d0\u4f9b\u529f\u80fd\u8c03\u63a7\uff08BDNF\u589e\u5f3a\u795e\u7ecf\u5143\u5b58\u6d3b\u548c\u7a81\u89e6\u6574\u5408\uff09\uff0c\u5b9e\u73b0&#8221;\u7ec6\u80de\u66ff\u4ee3+\u795e\u7ecf\u8425\u517b\u652f\u6301&#8221;\u7684\u53cc\u91cd\u6cbb\u7597\u4f18\u52bf\uff0c\u663e\u8457\u4f18\u4e8e\u5355\u4e00\u7597\u6cd5\u3002<\/li>\n<\/ul>\n<p><span data-pm-slice=\"1 1 [&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;outer&quot;,&quot;class&quot;:&quot;article135&quot;,&quot;label&quot;:&quot;edit by 135editor&quot;,&quot;data-pm-slice&quot;:&quot;0 0 []&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;paragraph&quot;,&quot;class&quot;:&quot;&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;list&quot;,&quot;class&quot;:&quot;&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;list&quot;,&quot;data-pm-slice&quot;:&quot;4 4 [\\&quot;para\\&quot;,{\\&quot;tagName\\&quot;:\\&quot;section\\&quot;,\\&quot;attributes\\&quot;:{\\&quot;data-role\\&quot;:\\&quot;outer\\&quot;,\\&quot;label\\&quot;:\\&quot;edit by 135editor\\&quot;,\\&quot;data-pm-slice\\&quot;:\\&quot;0 0 []\\&quot;},\\&quot;namespaceURI\\&quot;:\\&quot;http:\/\/www.w3.org\/1999\/xhtml\\&quot;},\\&quot;para\\&quot;,{\\&quot;tagName\\&quot;:\\&quot;section\\&quot;,\\&quot;attributes\\&quot;:{\\&quot;data-role\\&quot;:\\&quot;paragraph\\&quot;},\\&quot;namespaceURI\\&quot;:\\&quot;http:\/\/www.w3.org\/1999\/xhtml\\&quot;}]&quot;,&quot;class&quot;:&quot;&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;outer&quot;,&quot;class&quot;:&quot;article135&quot;,&quot;label&quot;:&quot;edit by 135editor&quot;,&quot;data-pm-slice&quot;:&quot;0 0 []&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;paragraph&quot;,&quot;class&quot;:&quot;&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;list&quot;,&quot;class&quot;:&quot;&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;list&quot;,&quot;data-pm-slice&quot;:&quot;4 4 [\\&quot;para\\&quot;,{\\&quot;tagName\\&quot;:\\&quot;section\\&quot;,\\&quot;attributes\\&quot;:{\\&quot;data-role\\&quot;:\\&quot;outer\\&quot;,\\&quot;label\\&quot;:\\&quot;edit by 135editor\\&quot;,\\&quot;data-pm-slice\\&quot;:\\&quot;0 0 []\\&quot;},\\&quot;namespaceURI\\&quot;:\\&quot;http:\/\/www.w3.org\/1999\/xhtml\\&quot;},\\&quot;para\\&quot;,{\\&quot;tagName\\&quot;:\\&quot;section\\&quot;,\\&quot;attributes\\&quot;:{\\&quot;data-role\\&quot;:\\&quot;paragraph\\&quot;},\\&quot;namespaceURI\\&quot;:\\&quot;http:\/\/www.w3.org\/1999\/xhtml\\&quot;}]&quot;,&quot;class&quot;:&quot;&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;p&quot;,&quot;attributes&quot;:{&quot;data-spm-anchor-id&quot;:&quot;5176.28103460.0.i20.39367551ItdekH&quot;,&quot;style&quot;:null},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;}]\">\u5c3d\u7ba1BDNF\u6cbb\u7597\u524d\u666f\u5e7f\u9614\uff0c\u4f46\u5728\u53ef\u884c\u6027\u4e0a\u9762\u4e34\u7740\u663e\u8457\u7684\u9012\u9001\u6311\u6218\uff1aBDNF\u5206\u5b50\u8f83\u5927\u3001\u534a\u8870\u671f\u77ed\uff0c\u96be\u4ee5\u7a7f\u900f\u8840\u8111\u5c4f\u969c\uff0c\u76f4\u63a5\u7ed9\u836f\u9700\u8981\u4fb5\u5165\u6027\u64cd\u4f5c\u4e14\u5b58\u5728\u766b\u75eb\u7b49\u98ce\u9669\u3002\u4e3a\u89e3\u51b3\u8fd9\u4e9b\u95ee\u9898\uff0c\u7814\u7a76\u4eba\u5458\u6b63\u63a2\u7d22\u7eb3\u7c73\u9897\u7c92\u9012\u9001\u7cfb\u7edf\u3001\u53ef\u8bf1\u5bfc\u57fa\u56e0\u8868\u8fbe\u7cfb\u7edf\uff08\u5982\u56db\u73af\u7d20\u54cd\u5e94\u542f\u52a8\u5b50\uff09\u4ee5\u53caCRISPR\u7cbe\u51c6\u6574\u5408\u6280\u672f\uff0c\u4ee5\u5b9e\u73b0BDNF\u7684\u9776\u5411\u3001\u53ef\u63a7\u8868\u8fbe\u3002<\/span><\/p>\n<p data-spm-anchor-id=\"5176.28103460.0.i20.39367551ItdekH\">\u540c\u65f6\uff0cBDNF\u4e0e\u5e72\u7ec6\u80de\u7597\u6cd5\u7684\u8054\u5408\u5e94\u7528\u5df2\u5c55\u73b0\u51fa\u663e\u8457\u4f18\u52bf\uff0c\u4e0d\u4ec5\u5ef6\u957f\u4e86\u836f\u6548\u6301\u7eed\u65f6\u95f4\uff0c\u8fd8\u6539\u5584\u4e86&#8221;\u5242\u672b\u73b0\u8c61&#8221;\uff0c\u4e3a\u5e15\u91d1\u68ee\u75c5\u4ece&#8221;\u75c7\u72b6\u63a7\u5236&#8221;\u5411&#8221;\u795e\u7ecf\u4fee\u590d&#8221;\u7684\u8f6c\u53d8\u63d0\u4f9b\u4e86\u5173\u952e\u7a81\u7834\u70b9\u3002<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%E5%B9%B2%E7%BB%86%E8%83%9E%E6%9B%BF%E4%BB%A3%E7%96%97%E6%B3%95%E4%B8%8E%E8%84%91%E6%BA%90%E6%80%A7%E7%A5%9E%E7%BB%8F%E8%90%A5%E5%85%BB%E5%9B%A0%E5%AD%90%EF%BC%88BDNF%EF%BC%89%E7%9A%84%E8%81%94%E5%90%88%E5%BA%94%E7%94%A8\"><\/span><strong>\u5e72\u7ec6\u80de\u66ff\u4ee3\u7597\u6cd5\u4e0e\u8111\u6e90\u6027\u795e\u7ecf\u8425\u517b\u56e0\u5b50\uff08BDNF\uff09\u7684\u8054\u5408\u5e94\u7528<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<h3><span class=\"ez-toc-section\" id=\"1_%E5%8D%8F%E5%90%8C%E5%A2%9E%E6%95%88%E7%9A%84%E6%9C%BA%E5%88%B6%EF%BC%9A%E4%B8%BA%E4%BD%95%E8%A6%81%E8%81%94%E5%90%88%EF%BC%9F\"><\/span>1. \u534f\u540c\u589e\u6548\u7684\u673a\u5236\uff1a\u4e3a\u4f55\u8981\u8054\u5408\uff1f<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p data-spm-anchor-id=\"5176.28103460.0.i14.39367551ItdekH\">\u5e15\u91d1\u68ee\u75c5\u7684\u6838\u5fc3\u75c5\u7406\u662f\u9ed1\u8d28\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u7684\u9000\u884c\u6027\u4e22\u5931\uff0c\u5bfc\u81f4\u7eb9\u72b6\u4f53\u591a\u5df4\u80fa\u6c34\u5e73\u4e0b\u964d\u3002\u7ec6\u80de\u66ff\u4ee3\u7597\u6cd5\u901a\u8fc7\u79fb\u690d\u5e72\u7ec6\u80de\u5206\u5316\u4e3a\u529f\u80fd\u6027\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\uff0c\u76f4\u63a5\u8865\u5145\u7f3a\u5931\u7684\u795e\u7ecf\u5143\uff1b\u800cBDNF\u4f5c\u4e3a\u5173\u952e\u795e\u7ecf\u8425\u517b\u56e0\u5b50\uff0c\u901a\u8fc7\u6fc0\u6d3bTrkB\u53d7\u4f53\u4e0b\u6e38\u7684PI3K\/Akt\u3001MAPK\/ERK\u7b49\u4fe1\u53f7\u901a\u8def\uff0c\u4fc3\u8fdb\u795e\u7ecf\u5143\u5b58\u6d3b\u3001\u7a81\u89e6\u53ef\u5851\u6027\u53ca\u6297\u51cb\u4ea1\uff0c\u540c\u65f6\u6291\u5236\u795e\u7ecf\u708e\u75c7\u53cd\u5e94\u3002\u4e24\u8005\u7684\u8054\u5408\u5b9e\u73b0\u4e86\u201c\u7ed3\u6784\u4fee\u590d\u201d\u4e0e\u201c\u529f\u80fd\u8c03\u63a7\u201d\u7684\u53cc\u91cd\u4f5c\u7528\uff1a<\/p>\n<ul class=\"list-paddingleft-1\">\n<li>\u4e92\u8865\u6027\uff1a\u5e72\u7ec6\u80de\u79fb\u690d\u89e3\u51b3\u795e\u7ecf\u5143\u6570\u91cf\u4e0d\u8db3\u7684\u95ee\u9898\uff0c\u800cBDNF\u901a\u8fc7\u8425\u517b\u652f\u6301\u548c\u6297\u708e\u4f5c\u7528\u7ef4\u6301\u79fb\u690d\u795e\u7ecf\u5143\u7684\u957f\u671f\u529f\u80fd\u6574\u5408\u3002<\/li>\n<li>\u4fe1\u53f7\u7ea7\u8054\u589e\u5f3a\uff1aBDNF\u7684\u65c1\u5206\u6ccc\u4f5c\u7528\u53ef\u6fc0\u6d3b\u79fb\u690d\u795e\u7ecf\u5143\u7684\u5b58\u6d3b\u4fe1\u53f7\uff08\u5982\u4e0a\u8c03Bcl-2\u3001\u6291\u5236Bax\uff09\uff0c\u540c\u65f6\u901a\u8fc7\u6291\u5236NF-\u03baB\u901a\u8def\u964d\u4f4e\u5c0f\u80f6\u8d28\u7ec6\u80de\u4ecb\u5bfc\u7684\u708e\u75c7\u635f\u4f24\uff0c\u4e3a\u79fb\u690d\u7ec6\u80de\u63d0\u4f9b\u518d\u751f\u5fae\u73af\u5883\u3002<\/li>\n<li>\u7a81\u89e6\u91cd\u5851\uff1aBDNF\u7684\u8f74\u7a81\u5f15\u5bfc\u6548\u5e94\u4fc3\u8fdb\u79fb\u690d\u795e\u7ecf\u5143\u4e0e\u5bbf\u4e3b\u795e\u7ecf\u7f51\u7edc\u7684\u8fde\u63a5\uff0c\u52a0\u901f\u529f\u80fd\u56de\u8def\u91cd\u5efa\uff0c\u5f25\u8865\u5355\u7eaf\u7ec6\u80de\u66ff\u4ee3\u53ef\u80fd\u5b58\u5728\u7684\u6574\u5408\u969c\u788d\u3002<span dir=\"auto\" data-pm-slice=\"0 0 []\"><br \/>\n<\/span><\/li>\n<\/ul>\n<p><span dir=\"auto\" data-pm-slice=\"0 0 []\">\u603b\u800c\u8a00\u4e4b\uff0c\u8fd9\u4e9b\u673a\u5236\u9610\u660e\u4e86\u5e72\u7ec6\u80de\u7597\u6cd5\u4e0eBDNF\u8054\u5408\u5e94\u7528\u5982\u4f55\u589e\u5f3a\u5e15\u91d1\u68ee\u75c5\u7684\u795e\u7ecf\u518d\u751f\u548c\u529f\u80fd\u6062\u590d\uff0c\u5982\u56fe1<\/span><span dir=\"auto\">\u6240\u793a\u3002<\/span><\/p>\n<section>\n<div id=\"attachment_20495\" style=\"width: 1958px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-20495\" class=\"wp-image-20495 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5fae\u4fe1\u56fe\u7247_2025-11-14_112513_205.png\" alt=\"\" width=\"1948\" height=\"1024\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5fae\u4fe1\u56fe\u7247_2025-11-14_112513_205.png 1948w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5fae\u4fe1\u56fe\u7247_2025-11-14_112513_205-300x158.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5fae\u4fe1\u56fe\u7247_2025-11-14_112513_205-1024x538.png 1024w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5fae\u4fe1\u56fe\u7247_2025-11-14_112513_205-768x404.png 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5fae\u4fe1\u56fe\u7247_2025-11-14_112513_205-1536x807.png 1536w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5fae\u4fe1\u56fe\u7247_2025-11-14_112513_205-18x9.png 18w\" sizes=\"(max-width: 1948px) 100vw, 1948px\" \/><p id=\"caption-attachment-20495\" class=\"wp-caption-text\">\u56fe1\uff1a\u5e72\u7ec6\u80de\u548c\u8111\u6e90\u6027\u795e\u7ecf\u8425\u517b\u56e0\u5b50\uff08BDNF\uff09\u7684\u4f5c\u7528\u673a\u5236<\/p><\/div>\n<\/section>\n<h3><span class=\"ez-toc-section\" id=\"2_%E6%8A%80%E6%9C%AF%E5%AE%9E%E7%8E%B0%E7%9A%84%E7%AD%96%E7%95%A5%EF%BC%9A%E5%A6%82%E4%BD%95%E5%AE%9E%E7%8E%B0%E8%81%94%E5%90%88%EF%BC%9F\"><\/span>2. \u6280\u672f\u5b9e\u73b0\u7684\u7b56\u7565\uff1a\u5982\u4f55\u5b9e\u73b0\u8054\u5408\uff1f<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u8054\u5408\u7b56\u7565\u7684\u5173\u952e\u5728\u4e8e\u57fa\u56e0\u5de5\u7a0b\u5316\u5e72\u7ec6\u80de\u7684\u8bbe\u8ba1\u4e0e\u7cbe\u51c6\u8c03\u63a7\uff1a<\/p>\n<ul class=\"list-paddingleft-1\">\n<li>\u57fa\u56e0\u4fee\u9970\u5e72\u7ec6\u80de\uff1a\u901a\u8fc7\u6162\u75c5\u6bd2\u8f7d\u4f53\u6216CRISPR\/Cas9\u6280\u672f\u5c06BDNF\u57fa\u56e0\u6574\u5408\u5230\u5e72\u7ec6\u80de\uff08\u5982iPSCs\u6216MSCs\uff09\u4e2d\uff0c\u4f7f\u5176\u5206\u5316\u4e3a\u591a\u5df4\u80fa\u80fd\u7956\u7ec6\u80de\u7684\u540c\u65f6\u6301\u7eed\u5206\u6cccBDNF\u3002\u4f8b\u5982\uff0cNurr1\/Pitx3\u8f6c\u5f55\u56e0\u5b50\u7684\u5171\u8868\u8fbe\u53ef\u5b9a\u5411\u8bf1\u5bfc\u5e72\u7ec6\u80de\u751f\u6210TH\u9633\u6027\u795e\u7ecf\u5143\uff0c\u800cBDNF\u7684\u8fc7\u8868\u8fbe\u8fdb\u4e00\u6b65\u589e\u5f3a\u5176\u5b58\u6d3b\u548c\u7a81\u89e6\u529f\u80fd\u3002<\/li>\n<li>\u52a8\u6001\u8c03\u63a7\u7cfb\u7edf\uff1a\u5f15\u5165\u56db\u73af\u7d20\u54cd\u5e94\u542f\u52a8\u5b50\uff08Tet-On\/Tet-Off\uff09\u7b49\u53ef\u8bf1\u5bfc\u7cfb\u7edf\uff0c\u901a\u8fc7\u5f3a\u529b\u9709\u7d20\u63a7\u5236BDNF\u7684\u8868\u8fbe\u6c34\u5e73\uff0c\u907f\u514d\u5174\u594b\u6027\u6bd2\u6027\u6216\u8fc7\u5ea6\u6fc0\u6d3b\u5e26\u6765\u7684\u98ce\u9669\u3002<\/li>\n<li>\u5b89\u5168\u673a\u5236\uff1a\u5728\u5de5\u7a0b\u5316\u5e72\u7ec6\u80de\u4e2d\u6574\u5408\u201c\u81ea\u6740\u57fa\u56e0\u201d\uff08\u5982HSV-tk\uff09\uff0c\u5728\u51fa\u73b0\u5f02\u5e38\u589e\u6b96\u6216\u514d\u75ab\u6392\u65a5\u65f6\uff0c\u901a\u8fc7\u524d\u836f\uff08\u5982\u66f4\u6614\u6d1b\u97e6\uff09\u9009\u62e9\u6027\u6e05\u9664\u79fb\u690d\u7ec6\u80de\uff0c\u63d0\u5347\u6cbb\u7597\u5b89\u5168\u6027\u3002<\/li>\n<li>\u9012\u9001\u4f18\u5316\uff1a\u5229\u7528\u5fae\u6d41\u63a7\u82af\u7247\u7b49\u6280\u672f\u6a21\u62df\u4f53\u5185\u73af\u5883\uff0c\u9a8c\u8bc1BDNF\u6d53\u5ea6\u68af\u5ea6\u5bf9\u8f74\u7a81\u751f\u957f\u65b9\u5411\u7684\u5f15\u5bfc\u4f5c\u7528\uff0c\u4e3a\u4f53\u5185\u79fb\u690d\u63d0\u4f9b\u9884\u5b9e\u9a8c\u652f\u6301\u3002<\/li>\n<\/ul>\n<h3><span class=\"ez-toc-section\" id=\"3_%E4%B8%B4%E5%BA%8A%E8%BD%AC%E5%8C%96%E7%9A%84%E4%BC%98%E5%8A%BF%E4%B8%8E%E5%89%8D%E6%99%AF%EF%BC%9A%E8%81%94%E5%90%88%E5%BA%94%E7%94%A8%E5%B8%A6%E6%9D%A5%E4%BB%80%E4%B9%88%E4%BB%B7%E5%80%BC%EF%BC%9F\"><\/span>3. \u4e34\u5e8a\u8f6c\u5316\u7684\u4f18\u52bf\u4e0e\u524d\u666f\uff1a\u8054\u5408\u5e94\u7528\u5e26\u6765\u4ec0\u4e48\u4ef7\u503c\uff1f<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u8054\u5408\u7597\u6cd5\u76f8\u8f83\u4e8e\u5355\u4e00\u7b56\u7565\u5177\u6709\u663e\u8457\u4f18\u52bf\uff0c\u5e76\u63a8\u52a8\u5e15\u91d1\u68ee\u75c5\u6cbb\u7597\u5411\u201c\u795e\u7ecf\u4fee\u590d\u201d\u8fc8\u8fdb\uff1a<\/p>\n<ul class=\"list-paddingleft-1\">\n<li>\u7597\u6548\u63d0\u5347\uff1a\u4e34\u5e8a\u524d\u7814\u7a76\u663e\u793a\uff0cBDNF\u4fee\u9970\u7684MSC\u79fb\u690d\u53ef\u4f7f<span class=\"\">\u5e15\u91d1\u68ee\u52a8\u7269\u6a21\u578b<\/span>\u7684\u65cb\u8f6c\u884c\u4e3a\u51cf\u5c11\u3001\u7eb9\u72b6\u4f53\u591a\u5df4\u80fa\u6c34\u5e73\u5347\u9ad8\uff0c\u4e14\u9ad8\u5242\u91cf\u7ec4\u5f71\u50cf\u5b66\u6539\u5584\u66f4\u663e\u8457\u3002\u7ed3\u54082025\u5e74\u300aNature\u300b\u62a5\u9053\u7684\u5e72\u7ec6\u80de\u79fb\u690d\u8bd5\u9a8c\uff0c\u8054\u5408BDNF\u7684\u7b56\u7565\u53ef\u80fd\u5ef6\u957f\u836f\u6548\u6301\u7eed\u65f6\u95f4\uff0c\u51cf\u5c11\u201c\u5242\u672b\u73b0\u8c61\u201d\uff0c\u5e76\u6539\u5584\u975e\u8fd0\u52a8\u75c7\u72b6\uff08\u5982\u6291\u90c1\uff09\u3002<\/li>\n<\/ul>\n<ul class=\"list-paddingleft-1\">\n<li>\u5b89\u5168\u6027\u589e\u5f3a\uff1a\u901a\u8fc7\u57fa\u56e0\u7f16\u8f91\u6280\u672f\uff08\u5982CRISPR\u7cbe\u51c6\u6574\u5408BDNF\u81f3\u201c\u5b89\u5168\u6e2f\u201d\u4f4d\u70b9\uff09\u964d\u4f4e\u63d2\u5165\u7a81\u53d8\u98ce\u9669\uff0c\u540c\u65f6\u52a8\u6001\u8c03\u63a7\u7cfb\u7edf\u51cf\u5c11\u8fc7\u5ea6\u8868\u8fbe\u526f\u4f5c\u7528\uff0c\u4f7f\u7597\u6cd5\u66f4\u7b26\u5408\u4e34\u5e8a\u8f6c\u5316\u6807\u51c6\u3002<\/li>\n<li>\u6807\u51c6\u5316\u6f5c\u529b\uff1aBDNF\u4fee\u9970\u7684\u5e72\u7ec6\u80de\u7597\u6cd5\u53ef\u6807\u51c6\u5316\u751f\u4ea7\uff0c\u5c24\u5176\u662fhESC\u884d\u751f\u7684\u7ec6\u80de\u5177\u5907\u6279\u6b21\u4e00\u81f4\u6027\uff0c\u4e3a\u201c\u73b0\u8d27\u578b\u201d\u7ec6\u80de\u836f\u7269\u5f00\u53d1\u5960\u5b9a\u57fa\u7840\u3002<\/li>\n<li>\u591a\u9776\u70b9\u5e72\u9884\uff1aBDNF\u4e0d\u4ec5\u4f5c\u7528\u4e8e\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\uff0c\u8fd8\u901a\u8fc7TrkB\u53d7\u4f53\u5e7f\u6cdb\u8c03\u8282\u7a81\u89e6\u53ef\u5851\u6027\u548c\u795e\u7ecf\u53d1\u751f\uff0c\u8986\u76d6\u5e15\u91d1\u68ee\u75c5\u4e2d\u7684\u795e\u7ecf\u9000\u884c\u6027\u53d8\u53ca\u795e\u7ecf\u708e\u75c7\u7b49\u591a\u91cd\u75c5\u7406\u673a\u5236\uff0c\u4e3a\u665a\u671f\u60a3\u8005\u63d0\u4f9b\u66f4\u5168\u9762\u7684\u6cbb\u7597\u9009\u62e9\u3002<\/li>\n<\/ul>\n<p>\u603b\u7ed3\uff1a\u5e72\u7ec6\u80de\u4e0eBDNF\u7684\u8054\u5408\u7b56\u7565\u901a\u8fc7\u7ed3\u6784\u4fee\u590d\u4e0e\u529f\u80fd\u8c03\u63a7\u7684\u534f\u540c\u4f5c\u7528\uff0c\u514b\u670d\u4e86\u4f20\u7edf\u7597\u6cd5\u7684\u5c40\u9650\u6027\uff0c\u4ee3\u8868\u4e86\u5e15\u91d1\u68ee\u75c5\u6cbb\u7597\u4ece\u201c\u75c7\u72b6\u63a7\u5236\u201d\u5411\u201c\u795e\u7ecf\u518d\u751f\u201d\u7684\u8303\u5f0f\u8f6c\u53d8\u3002\u968f\u7740\u57fa\u56e0\u5de5\u7a0b\u3001\u9012\u9001\u6280\u672f\u548c\u4e34\u5e8a\u8bd5\u9a8c\u7684\u63a8\u8fdb\uff0c\u8fd9\u4e00\u8054\u5408\u7597\u6cd5\u6709\u671b\u6210\u4e3a\u672a\u6765\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u7684\u6838\u5fc3\u6cbb\u7597\u6a21\u5f0f\u3002<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%E7%BB%93%E8%AE%BA\"><\/span><strong>\u7ed3\u8bba<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>\u5e72\u7ec6\u80de\u7597\u6cd5\u4e0e\u8111\u6e90\u6027\u795e\u7ecf\u8425\u517b\u56e0\u5b50\uff08BDNF\uff09\u589e\u5f3a\u7597\u6cd5\u7684\u7ed3\u5408\uff0c\u4ee3\u8868\u4e86\u5e15\u91d1\u68ee\u75c5\u6cbb\u7597\u9886\u57df\u4e00\u4e2a\u5145\u6ee1\u5e0c\u671b\u4e14\u6781\u5177\u521b\u65b0\u6027\u7684\u65b9\u5411\u3002\u8fd9\u79cd\u534f\u540c\u7597\u6cd5\u901a\u8fc7\u540c\u65f6\u89e3\u51b3\u795e\u7ecf\u5143\u4e22\u5931\u548c\u8425\u517b\u652f\u6301\u95ee\u9898\uff0c\u4e0d\u4ec5\u6709\u671b\u6539\u5584\u75c7\u72b6\uff0c\u8fd8\u6709\u671b\u5ef6\u7f13\u75be\u75c5\u8fdb\u5c55\u3002<\/p>\n<p>\u968f\u7740\u4e0d\u65ad\u5b8c\u5584\u548c\u9a8c\u8bc1\uff0c\u8be5\u7b56\u7565\u6709\u671b\u4e3a\u66f4\u6709\u6548\u3001\u66f4\u6301\u4e45\u7684\u7597\u6cd5\u94fa\u5e73\u9053\u8def\uff0c\u4e3a\u9762\u4e34\u5e15\u91d1\u68ee\u75c5\u6311\u6218\u7684\u60a3\u8005\u5e26\u6765\u5e0c\u671b\u3002<\/p>\n<\/section>\n<\/section>\n<blockquote><p>\u53c2\u8003\u8d44\u6599\uff1a<\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">[1] <\/span><\/span><span data-pm-slice=\"0 0 []\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">Jonny, J., Larasati, AD, Sunjaya, QA\u00a0<\/span><\/span><\/span><i><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7b49.<\/span><\/span><\/i><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u00a0\u5e72\u7ec6\u80de\u7597\u6cd5\u4e0e\u8111\u6e90\u6027\u795e\u7ecf\u8425\u517b\u56e0\u5b50 (BDNF) \u5728\u5e15\u91d1\u68ee\u75c5\u4e2d\u7684\u534f\u540c\u4f5c\u7528\uff1a\u8054\u5408\u795e\u7ecf\u518d\u751f\u7b56\u7565\u7684\u7b80\u8981\u7efc\u8ff0.\u00a0<\/span><\/span><i><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e2d\u534e\u795e\u7ecf\u5916\u79d1\u6742\u5fd7<\/span><\/span><\/i>\u00a0<b><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">11<\/span><\/span><\/b><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> , 29 (2025). https:\/\/doi.org\/10.1186\/s41016-025-00415-5<\/span><\/span><\/p>\n<p>\u514d\u8d23\u8bf4\u660e\uff1a\u672c\u6587\u4ec5\u7528\u4e8e\u4f20\u64ad\u79d1\u666e\u77e5\u8bc6\uff0c\u5206\u4eab\u884c\u4e1a\u89c2\u70b9\uff0c\u4e0d\u6784\u6210\u4efb\u4f55\u4e34\u5e8a\u8bca\u65ad\u5efa\u8bae\uff01\u676d\u5409\u5e72\u7ec6\u80de\u6240\u53d1\u5e03\u7684\u4fe1\u606f\u4e0d\u80fd\u66ff\u4ee3\u533b\u751f\u6216\u836f\u5242\u5e08\u7684\u4e13\u4e1a\u5efa\u8bae\u3002\u5982\u6709\u7248\u6743\u7b49\u7591\u95ee\uff0c\u8bf7\u968f\u65f6\u8054\u7cfb\u6211\u3002<\/p><\/blockquote>","protected":false},"excerpt":{"rendered":"<p>\u6458\u8981\uff1a\u5e15\u91d1\u68ee\u75c5\u4f5c\u4e3a\u4e00\u79cd\u8fdb\u884c\u6027\u52a0\u91cd\u7684\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\uff0c\u76ee\u524d\u4ee5\u5de6\u65cb\u591a\u5df4\u4e3a\u4ee3\u8868\u7684\u4f20\u7edf\u7597\u6cd5\u867d\u80fd\u7f13\u89e3\u8fd0\u52a8\u75c7\u72b6\uff0c\u4f46\u96be\u4ee5\u9006\u8f6c\u957f [&hellip;]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[76],"tags":[159,158],"_links":{"self":[{"href":"https:\/\/www.hjtdsm.cn\/ar\/wp-json\/wp\/v2\/posts\/20491"}],"collection":[{"href":"https:\/\/www.hjtdsm.cn\/ar\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hjtdsm.cn\/ar\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/ar\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/ar\/wp-json\/wp\/v2\/comments?post=20491"}],"version-history":[{"count":1,"href":"https:\/\/www.hjtdsm.cn\/ar\/wp-json\/wp\/v2\/posts\/20491\/revisions"}],"predecessor-version":[{"id":20499,"href":"https:\/\/www.hjtdsm.cn\/ar\/wp-json\/wp\/v2\/posts\/20491\/revisions\/20499"}],"wp:attachment":[{"href":"https:\/\/www.hjtdsm.cn\/ar\/wp-json\/wp\/v2\/media?parent=20491"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/ar\/wp-json\/wp\/v2\/categories?post=20491"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/ar\/wp-json\/wp\/v2\/tags?post=20491"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}