{"id":20926,"date":"2025-12-15T15:40:50","date_gmt":"2025-12-15T07:40:50","guid":{"rendered":"https:\/\/www.hjtdsm.cn\/?p=20926"},"modified":"2025-12-15T15:41:21","modified_gmt":"2025-12-15T07:41:21","slug":"https-www-hjtdsm-cn-stem-cells-stem-cell-therapy-20926-html","status":"publish","type":"post","link":"https:\/\/www.hjtdsm.cn\/ar\/stem-cells\/stem-cell-therapy\/20926.html","title":{"rendered":"\u81ea\u4f53\u5e72\u7ec6\u80de\u8054\u5408\u751f\u957f\u56e0\u5b50\u6cbb\u7597\u963f\u5c14\u8328\u6d77\u9ed8\u75c56\u4e2a\u6708\u540e\uff1a\u8ba4\u77e5\u529f\u80fd\u3001\u8111\u4ee3\u8c22\u4e0e\u6d77\u9a6c\u4f53\u7ed3\u6784\u7684\u540c\u6b65\u6539\u5584"},"content":{"rendered":"<section data-role=\"paragraph\"><a href=\"https:\/\/www.hjtdsm.cn\/ar\/research\/ns\/ad\/20831.html\/\" target=\"_blank\" rel=\"noopener\"><span 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id=\"%E8%87%AA%E4%BD%93%E5%B9%B2%E7%BB%86%E8%83%9E%E8%81%94%E5%90%88%E7%94%9F%E9%95%BF%E5%9B%A0%E5%AD%90%E6%B2%BB%E7%96%97%E4%B8%AD%E9%87%8D%E5%BA%A6%E9%98%BF%E5%B0%94%E8%8C%A8%E6%B5%B7%E9%BB%98%E7%97%856%E4%B8%AA%E6%9C%88%E5%90%8E%EF%BC%9A%E8%AE%A4%E7%9F%A5%E5%8A%9F%E8%83%BD%E3%80%81%E8%84%91%E4%BB%A3%E8%B0%A2%E4%B8%8E%E6%B5%B7%E9%A9%AC%E4%BD%93%E7%BB%93%E6%9E%84%E7%9A%84%E5%90%8C%E6%AD%A5%E6%94%B9%E5%96%84\"><\/span>\u81ea\u4f53\u5e72\u7ec6\u80de\u8054\u5408\u751f\u957f\u56e0\u5b50\u6cbb\u7597\u4e2d\u91cd\u5ea6\u963f\u5c14\u8328\u6d77\u9ed8\u75c56\u4e2a\u6708\u540e\uff1a\u8ba4\u77e5\u529f\u80fd\u3001\u8111\u4ee3\u8c22\u4e0e\u6d77\u9a6c\u4f53\u7ed3\u6784\u7684\u540c\u6b65\u6539\u5584<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>\u4e3a\u7cfb\u7edf\u8bc4\u4f30\u81ea\u4f53\u5e72\u7ec6\u80de\u8054\u5408\u751f\u957f\u56e0\u5b50\u6cbb\u7597\u4e2d\u91cd\u5ea6\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u5b89\u5168\u6027\u3001\u6709\u6548\u6027\u53ca\u5176\u6f5c\u5728\u673a\u5236\uff0c\u672c\u7814\u7a76\u5f00\u5c55\u4e86\u4e00\u9879\u524d\u77bb\u6027\u4e34\u5e8a\u63a2\u7d22\uff0c\u76f8\u5173\u6210\u679c\u5df2\u5728\u300aMolecular Neurobiology\u300b\u671f\u520a\u4e0a\u53d1\u8868\uff0c\u6807\u9898\u4e3a<a href=\"https:\/\/link.springer.com\/article\/10.1007\/s12035-025-05583-0#citeas\" target=\"_blank\" rel=\"noopener nofollow\">\u201c\u81ea\u4f53\u8840\u6db2\u6765\u6e90\u5e72\u7ec6\u80de\u8054\u5408\u751f\u957f\u56e0\u5b50\u6cbb\u7597\u4e2d\u91cd\u5ea6\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7597\u6548\uff1a\u4e00\u9879\u4e34\u5e8a\u8bd5\u9a8c\u201d<\/a><sup>[1]<\/sup>\u3002<\/p>\n<section><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-20934 aligncenter\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-15_112328_407.png\" alt=\"\" width=\"701\" height=\"395\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-15_112328_407.png 701w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-15_112328_407-300x169.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-15_112328_407-18x10.png 18w\" sizes=\"(max-width: 701px) 100vw, 701px\" \/><\/section>\n<p>\u672c\u7814\u7a76\u63d0\u51fa\u4ee5\u4e0b\u5047\u8bbe\uff1aABSCs\u4e0e\u751f\u957f\u56e0\u5b50\u8054\u5408\u5e94\u7528\u53ef\u901a\u8fc7\u6fc0\u6d3bPI3K\/Akt\u548cMAPK\/ERK\u7b49\u5173\u952e\u4fe1\u53f7\u901a\u8def\uff0c\u4fc3\u8fdb\u795e\u7ecf\u5143\u5b58\u6d3b\u3001\u589e\u5f3a\u7a81\u89e6\u53ef\u5851\u6027\uff0c\u4ece\u800c\u6539\u5584\u8ba4\u77e5\u529f\u80fd\u5e76\u5ef6\u7f13\u75be\u75c5\u8fdb\u5c55\u3002\u540c\u65f6\uff0c\u7814\u7a76\u4e5f\u5168\u9762\u8bc4\u4f30\u4e86\u8be5\u7597\u6cd5\u5728\u4e34\u5e8a\u5e94\u7528\u4e2d\u53ef\u80fd\u9047\u5230\u7684\u4e0d\u826f\u4e8b\u4ef6\u3001\u514d\u75ab\u53cd\u5e94\u53ca\u5176\u4ed6\u6f5c\u5728\u98ce\u9669\uff0c\u4ee5\u9a8c\u8bc1\u5176\u5b89\u5168\u6027\u4e0e\u53ef\u884c\u6027\u3002<\/p>\n<p>\u521d\u6b65\u7ed3\u679c\u663e\u793a\uff1a<strong>ABSCs\u8054\u5408\u751f\u957f\u56e0\u5b50\u6cbb\u7597\u663e\u8457\u6539\u5584\u4e86\u60a3\u8005\u7684\u8ba4\u77e5\u529f\u80fd\uff0c\u964d\u4f4e\u4e86\u8111\u5185\u6dc0\u7c89\u6837\u6591\u5757\u8d1f\u8377\uff0c\u5e76\u5728\u795e\u7ecf\u5f71\u50cf\u5b66\u4e2d\u89c2\u5bdf\u5230\u79ef\u6781\u7684\u7ed3\u6784\u4e0e\u4ee3\u8c22\u53d8\u5316\u3002\u4e0e<span class=\"\">\u5f02\u4f53\u5e72\u7ec6\u80de<\/span>\u76f8\u6bd4\uff0c\u81ea\u4f53\u5e72\u7ec6\u80de\u6cbb\u7597\u8fdb\u4e00\u6b65\u964d\u4f4e\u4e86\u514d\u75ab\u6392\u65a5\u98ce\u9669\uff0c\u5b89\u5168\u6027\u66f4\u9ad8\u3002<\/strong>\u6b64\u5916\uff0c\u751f\u957f\u56e0\u5b50\u7684\u534f\u540c\u4f7f\u7528\u6709\u52a9\u4e8e\u589e\u5f3a\u5e72\u7ec6\u80de\u7597\u6548\uff0c\u4e0e\u65e2\u5f80\u7814\u7a76\u7ed3\u8bba\u4e00\u81f4\u3002\u672c\u7814\u7a76\u4e3aABSCs\u8054\u5408\u751f\u957f\u56e0\u5b50\u6cbb\u7597\u4e2d\u91cd\u5ea6AD\u63d0\u4f9b\u4e86\u521d\u6b65\u7684\u4e34\u5e8a\u8bc1\u636e\uff0c\u652f\u6301\u5176\u5177\u6709\u503c\u5f97\u6df1\u5165\u63a2\u7d22\u7684\u6cbb\u7597\u6f5c\u529b\u3002<\/p>\n<\/section>\n<h2><span class=\"ez-toc-section\" id=\"%E6%96%B9%E6%B3%95%E4%B8%8E%E6%A0%87%E5%87%86\"><\/span><strong>\u65b9\u6cd5\u4e0e\u6807\u51c6<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>\u672c\u7814\u7a76\u91c7\u7528\u4e86\u4e00\u9879\u4e25\u8c28\u4e14\u591a\u7ef4\u5ea6\u7684\u65b9\u6cd5\uff0c\u65e8\u5728\u7cfb\u7edf\u8bc4\u4f30\u81ea\u4f53\u5e72\u7ec6\u80de\u8054\u5408\u751f\u957f\u56e0\u5b50\u6cbb\u7597\u4e2d\u91cd\u5ea6\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u7597\u6548\u4e0e\u673a\u5236\u3002\u5177\u4f53\u65b9\u6cd5\u53ef\u6982\u62ec\u5982\u4e0b\uff1a<\/p>\n<p><strong>\u7814\u7a76\u8bbe\u8ba1\u4e0e\u5b9e\u65bd\uff1a<\/strong>\u672c\u7814\u7a76\u4e3a\u4e00\u9879\u524d\u77bb\u6027\u3001\u5355\u4e2d\u5fc3\u3001\u63a2\u7d22\u6027\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\u3002\u91c7\u7528\u8ba1\u7b97\u673a\u751f\u6210\u7684\u533a\u7ec4\u968f\u673a\u5316\u65b9\u6cd5\uff08\u533a\u7ec4\u5927\u5c0f\u4e3a4\uff09\u5c06\u5408\u683c\u53d7\u8bd5\u8005\u5206\u7ec4\uff0c\u5e76\u901a\u8fc7\u987a\u5e8f\u7f16\u53f7\u7684\u5bc6\u5c01\u4e0d\u900f\u660e\u4fe1\u5c01\u5b9e\u73b0\u5206\u914d\u9690\u85cf\u3002\u5c3d\u7ba1\u5bf9\u60a3\u8005\u548c\u6cbb\u7597\u533b\u5e08\u672a\u8bbe\u76f2\uff08\u51fa\u4e8e\u6cbb\u7597\u64cd\u4f5c\u9700\u8981\uff09\uff0c\u4f46\u4e3a\u6700\u5927\u7a0b\u5ea6\u51cf\u5c11\u6d4b\u91cf\u504f\u501a\uff0c\u7814\u7a76\u91c7\u7528\u4e86\u8bc4\u4f30\u8005\u76f2\u6cd5\uff0c\u5373\u6240\u6709\u8fdb\u884c\u8ba4\u77e5\u8bc4\u4f30\u3001\u795e\u7ecf\u5f71\u50cf\u5224\u8bfb\u548c\u5b9e\u9a8c\u5ba4\u5206\u6790\u7684\u7814\u7a76\u4eba\u5458\u5747\u5bf9\u5206\u7ec4\u4fe1\u606f\u4e0d\u77e5\u60c5\u3002<\/p>\n<p><strong>\u7814\u7a76\u5bf9\u8c61\u4e0e\u5e72\u9884\u63aa\u65bd\uff1a<\/strong>\u7eb3\u5165\u5e74\u9f8460\u201380\u5c81\u3001\u7ecf\u4e34\u5e8a\u53ca\u03b2-\u6dc0\u7c89\u6837\u86cb\u767d<span class=\"\">PET-CT<\/span>\u786e\u8bca\u7684\u4e2d\u91cd\u5ea6AD\u60a3\u8005\u3002\u53d7\u8bd5\u8005\u968f\u673a\u5206\u4e3a\u4e24\u7ec4\uff1a\u5b9e\u9a8c\u7ec4\u63a5\u53d7ABSCs\u8054\u5408\u751f\u957f\u56e0\u5b50\uff08BDNF\u3001VEGF\u3001IGF-1\uff09\u9759\u8109\u8f93\u6ce8\uff1b\u5bf9\u7167\u7ec4\u4ec5\u63a5\u53d7\u6807\u51c6\u836f\u7269\u6cbb\u7597\u3002ABSCs\u53d6\u81ea\u60a3\u8005\u5916\u5468\u8840\uff0c\u7ecf\u5bc6\u5ea6\u68af\u5ea6\u79bb\u5fc3\u4e0e\u6d41\u5f0f\u7ec6\u80de\u672f\u9274\u5b9a\u540e\u65b0\u9c9c\u5236\u5907\uff0c\u4e8e3\u5c0f\u65f6\u5185\u56de\u8f93\uff0c\u4e0d\u4e88\u4f53\u5916\u6269\u589e\u3002\u751f\u957f\u56e0\u5b50\u6309\u6807\u51c6\u5316\u5242\u91cf\u914d\u5236\u3002\u5168\u7597\u7a0b\u5171\u8fdb\u884c3\u6b21\u8f93\u6ce8\uff0c\u6bcf\u6b21\u95f4\u96944\u5468\u3002<\/p>\n<h3><span class=\"ez-toc-section\" id=\"%E8%AF%84%E4%BC%B0%E6%8C%87%E6%A0%87%E4%B8%8E%E6%95%B0%E6%8D%AE%E5%88%86%E6%9E%90\"><\/span>\u8bc4\u4f30\u6307\u6807\u4e0e\u6570\u636e\u5206\u6790<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u7597\u6548\u4e0e\u673a\u5236\u8bc4\u4f30\u91c7\u7528\u591a\u5c42\u9762\u3001\u7eb5\u5411\u7684\u8bbe\u8ba1\uff1a<\/p>\n<section data-role=\"list\">\n<section data-role=\"list\">\n<section data-role=\"list\">\n<section data-role=\"list\">\n<section data-role=\"list\">\n<ul class=\"list-paddingleft-1\">\n<li><strong>\u4e34\u5e8a\u7ed3\u5c40\uff1a<\/strong>\u4e3b\u8981\u4f7f\u7528\u7b80\u6613\u7cbe\u795e\u72b6\u6001\u68c0\u67e5\u91cf\u8868\u3001\u4e34\u5e8a\u75f4\u5446\u8bc4\u5b9a\u91cf\u8868-\u603b\u5206\u548c\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u8bc4\u4f30\u91cf\u8868-\u8ba4\u77e5\u5b50\u91cf\u8868\uff0c\u5728\u57fa\u7ebf\u3001\u6cbb\u7597\u540e3\u4e2a\u6708\u548c6\u4e2a\u6708\u8bc4\u4f30\u8ba4\u77e5\u529f\u80fd\u3002<\/li>\n<\/ul>\n<\/section>\n<section data-role=\"list\">\n<ul class=\"list-paddingleft-1\">\n<li><strong>\u795e\u7ecf\u5f71\u50cf\u5b66\u751f\u7269\u6807\u5fd7\u7269\uff1a<\/strong>\u5728\u57fa\u7ebf\u548c\u6cbb\u7597\u540e6\u4e2a\u6708\uff0c\u901a\u8fc7\u6dc0\u7c89\u6837\u86cb\u767dPET-CT\uff08\u91cf\u5316Centiloid\u503c\uff09\u3001\u6c1f\u4ee3\u8131\u6c27\u8461\u8404\u7cd6-PET\uff08\u8bc4\u4f30\u8111\u4ee3\u8c22\uff09\u548c\u78c1\u5171\u632f\u6210\u50cf\uff08\u6d4b\u91cf\u6d77\u9a6c\u4f53\u79ef\uff09\u6765\u8bc4\u4f30\u5927\u8111\u75c5\u7406\u4e0e\u7ed3\u6784\u53d8\u5316\u3002<\/li>\n<\/ul>\n<\/section>\n<\/section>\n<section data-role=\"list\">\n<ul class=\"list-paddingleft-1\">\n<li><strong>\u5206\u5b50\u673a\u5236\u63a2\u7d22\uff1a<\/strong>\u901a\u8fc7\u9176\u8054\u514d\u75ab\u5438\u9644\u6d4b\u5b9a\u68c0\u6d4b\u8840\u6d46\u708e\u75c7\u56e0\u5b50\u6c34\u5e73\uff1b\u901a\u8fc7\u86cb\u767d\u8d28\u5370\u8ff9\u6cd5\u5206\u6790\u5916\u5468\u8840\u5355\u6838\u7ec6\u80de\u4e2dPI3K\/Akt\u3001MAPK\/ERK\u7b49\u4fe1\u53f7\u901a\u8def\u5173\u952e\u86cb\u767d\u7684\u78f7\u9178\u5316\u4e0e\u8868\u8fbe\u6c34\u5e73\u3002<\/li>\n<\/ul>\n<\/section>\n<\/section>\n<section data-role=\"list\">\n<ul class=\"list-paddingleft-1\">\n<li><strong>\u5b89\u5168\u6027\u76d1\u6d4b\uff1a<\/strong>\u5168\u7a0b\u8bb0\u5f55\u548c\u5206\u7c7b\u4e0d\u826f\u4e8b\u4ef6\uff0c\u5e76\u5b9a\u671f\u8fdb\u884c\u5b9e\u9a8c\u5ba4\u68c0\u67e5\u3002<\/li>\n<\/ul>\n<\/section>\n<\/section>\n<section data-role=\"list\">\n<ul class=\"list-paddingleft-1\">\n<li><strong>\u7edf\u8ba1\u5206\u6790\uff1a<\/strong>\u91c7\u7528\u63cf\u8ff0\u6027\u7edf\u8ba1\u603b\u7ed3\u57fa\u7ebf\u7279\u5f81\u3002\u4e3b\u8981\u4f7f\u7528\u914d\u5bf9t\u68c0\u9a8c\u8fdb\u884c\u7ec4\u5185\u524d\u540e\u6bd4\u8f83\uff0c\u4f7f\u7528\u72ec\u7acb\u6837\u672ct\u68c0\u9a8c\u6216Mann-Whitney U\u68c0\u9a8c\u8fdb\u884c\u7ec4\u95f4\u6bd4\u8f83\u3002\u5bf9\u4e8e\u7eb5\u5411\u91cd\u590d\u6d4b\u91cf\u6570\u636e\uff08\u5982\u5f71\u50cf\u5b66\u548c\u5206\u5b50\u6570\u636e\uff09\uff0c\u91c7\u7528\u7ebf\u6027\u6df7\u5408\u6548\u5e94\u6a21\u578b\u8fdb\u884c\u5206\u6790\u3002<\/li>\n<\/ul>\n<\/section>\n<\/section>\n<h2><span class=\"ez-toc-section\" id=\"%E5%8F%82%E4%B8%8E%E6%82%A3%E8%80%85%E5%8F%8A%E5%85%B6%E7%89%B9%E5%BE%81\"><\/span><strong>\u53c2\u4e0e\u60a3\u8005\u53ca\u5176\u7279\u5f81<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>\u672c\u7814\u7a76\u5171\u7eb3\u516538\u4f8b<span class=\"\">\u4e2d\u91cd\u5ea6AD\u60a3\u8005<\/span>\uff0c\u968f\u673a\u5206\u914d\u81f3\u5b9e\u9a8c\u7ec4\uff0823\u4f8b\uff0c\u63a5\u53d7ABSCs\u8054\u5408\u751f\u957f\u56e0\u5b50\u6cbb\u7597\uff09\u548c\u5bf9\u7167\u7ec4\uff0815\u4f8b\uff0c\u63a5\u53d7\u6807\u51c6\u836f\u7269\u6cbb\u7597\uff09\u3002<span dir=\"auto\" data-pm-slice=\"0 0 []\">\u4e24\u7ec4\u53d7\u8bd5\u8005\u7684\u57fa\u7ebf\u7279\u5f81\u5177\u6709\u53ef\u6bd4\u6027\uff0c\u5728\u5e74\u9f84\u3001\u6027\u522b\u3001\u75be\u75c5\u4e25\u91cd\u7a0b\u5ea6\u548c\u8ba4\u77e5\u8bc4\u5206\u65b9\u9762\u5747\u65e0\u663e\u8457\u5dee\u5f02\uff08\u88681<\/span><span dir=\"auto\">\uff09\u3002<\/span>\u5e73\u5747\u5e74\u9f8472.3\u5c81\uff0c\u5973\u6027\u5360\u6bd460%\uff0c\u4ee5\u4e2d\u5ea6AD\u4e3a\u4e3b\u3002<\/p>\n<section>\n<div id=\"attachment_20933\" style=\"width: 844px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-20933\" class=\"wp-image-20933 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-15_113631_541.png\" alt=\"\" width=\"834\" height=\"838\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-15_113631_541.png 834w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-15_113631_541-300x300.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-15_113631_541-150x150.png 150w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-15_113631_541-768x772.png 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-15_113631_541-12x12.png 12w\" sizes=\"(max-width: 834px) 100vw, 834px\" \/><p id=\"caption-attachment-20933\" class=\"wp-caption-text\">\u88681\uff1a\u60a3\u8005\u6570\u636e<\/p><\/div>\n<\/section>\n<p>\u4e24\u7ec4\u5728\u5e74\u9f84\u3001\u6027\u522b\u3001\u75be\u75c5\u4e25\u91cd\u7a0b\u5ea6\u53ca\u57fa\u7ebf\u8ba4\u77e5\u8bc4\u5206\u7b49\u65b9\u9762\u5747\u5177\u53ef\u6bd4\u6027\uff08p\uff1e0.05\uff09\u3002\u6240\u6709\u53d7\u8bd5\u8005\u5747\u5b8c\u6210\u5168\u90e8\u6cbb\u7597\u53ca3\u4e2a\u6708\u30016\u4e2a\u6708\u968f\u8bbf\uff0c\u65e0\u8131\u843d\u75c5\u4f8b\uff0c\u6570\u636e\u5b8c\u6574\u6027\u826f\u597d\uff08\u56fe1\uff09\u3002<\/p>\n<section>\n<div id=\"attachment_20932\" style=\"width: 2042px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-20932\" class=\"wp-image-20932 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/\u5fae\u4fe1\u56fe\u7247_2025-12-15_113654_285.png\" alt=\"\" width=\"2032\" height=\"804\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/\u5fae\u4fe1\u56fe\u7247_2025-12-15_113654_285.png 2032w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/\u5fae\u4fe1\u56fe\u7247_2025-12-15_113654_285-300x119.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/\u5fae\u4fe1\u56fe\u7247_2025-12-15_113654_285-1024x405.png 1024w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/\u5fae\u4fe1\u56fe\u7247_2025-12-15_113654_285-768x304.png 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/\u5fae\u4fe1\u56fe\u7247_2025-12-15_113654_285-1536x608.png 1536w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/\u5fae\u4fe1\u56fe\u7247_2025-12-15_113654_285-18x7.png 18w\" sizes=\"(max-width: 2032px) 100vw, 2032px\" \/><p id=\"caption-attachment-20932\" class=\"wp-caption-text\">\u56fe2\uff1a\u7814\u7a76\u8bbe\u8ba1\uff1a\u672c\u524d\u77bb\u6027\u4e34\u5e8a\u8bd5\u9a8c\u8bbe\u8ba1\u4e3a\u5355\u4e2d\u5fc3\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\uff08RCT\uff09\u3002\u5165\u7ec4\u60a3\u8005\u88ab\u968f\u673a\u5206\u4e3a\u5bf9\u7167\u7ec4\u548c\u5b9e\u9a8c\u7ec4\u3002\u7814\u7a76\u671f\u95f4\u65e0\u53d7\u8bd5\u8005\u9000\u51fa\u3002<\/p><\/div>\n<\/section>\n<p>\u5bf9\u7167\u7ec4\u5747\u63a5\u53d7\u7a33\u5b9a\u7684\u6807\u51c6\u836f\u7269\u6cbb\u7597\uff08\u5982\u4e59\u9170\u80c6\u78b1\u916f\u9176\u6291\u5236\u5242\u548c\/\u6216\u7f8e\u91d1\u521a\uff09\uff0c\u4e14\u5728\u5165\u7ec4\u524d\u81f3\u5c1112\u5468\u53ca\u7814\u7a76\u671f\u95f4\u65b9\u6848\u4fdd\u6301\u4e0d\u53d8\u3002\u7814\u7a76\u8005\u6307\u51fa\uff0c\u5c3d\u7ba1\u4e24\u7ec4\u57fa\u7ebf\u4e25\u91cd\u7a0b\u5ea6\u7ecf\u8c03\u6574\u540e\u53ef\u6bd4\uff0c\u4f46\u60a3\u8005\u95f4\u4ecd\u5b58\u5728\u4e00\u5b9a\u5f02\u8d28\u6027\uff0c\u672a\u6765\u7814\u7a76\u53ef\u91c7\u7528\u5206\u5c42\u968f\u673a\u4ee5\u63d0\u9ad8\u7ec4\u95f4\u540c\u8d28\u6027\u3002<\/p>\n<h2><span class=\"ez-toc-section\" id=\"ABSCs%E6%B2%BB%E7%96%97%E6%94%B9%E5%96%84%E4%BA%86%E9%98%BF%E5%B0%94%E8%8C%A8%E6%B5%B7%E9%BB%98%E7%97%85%E6%82%A3%E8%80%85%E8%AE%A4%E7%9F%A5%E5%8A%9F%E8%83%BD%E7%9A%84%E5%85%B7%E4%BD%93%E8%A1%A8%E7%8E%B0\"><\/span><strong>ABSCs\u6cbb\u7597\u6539\u5584\u4e86\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u60a3\u8005\u8ba4\u77e5\u529f\u80fd\u7684\u5177\u4f53\u8868\u73b0<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>\u6839\u636e\u7814\u7a76\u6570\u636e\uff0cABSCs\u8054\u5408\u751f\u957f\u56e0\u5b50\u6cbb\u7597\u5bf9\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u60a3\u8005\u7684\u8ba4\u77e5\u529f\u80fd\u6539\u5584\u8868\u73b0\u5728\u4ee5\u4e0b\u4e09\u4e2a\u65b9\u9762\uff0c\u4e14\u6539\u5584\u5177\u6709\u7edf\u8ba1\u663e\u8457\u6027\u548c\u8f83\u5927\u7684\u6548\u5e94\u91cf\uff1a<\/p>\n<p>\u7b2c\u4e00\uff0c<strong>\u5728\u6574\u4f53\u8ba4\u77e5\u72b6\u6001\u65b9\u9762\uff0c\u6cbb\u7597\u663e\u8457\u63d0\u5347\u4e86\u60a3\u8005\u7684<span class=\"\">MMSE<\/span>\u8bc4\u5206\uff08\u56fe2A\uff09\u3002\u5b9e\u9a8c\u7ec4\u60a3\u8005\u7684MMSE\u5e73\u5747\u5206\u5728\u6cbb\u75973\u4e2a\u6708\u540e\u5373\u663e\u8457\u589e\u52a03.4\u5206\uff0c\u5e76\u57286\u4e2a\u6708\u65f6\u8fdb\u4e00\u6b65\u63d0\u5347\u81f3\u6bd4\u57fa\u7ebf\u9ad84.1\u5206<\/strong>\u3002\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u5bf9\u7167\u7ec4\u7684\u5206\u6570\u5728\u6574\u4e2a\u7814\u7a76\u671f\u95f4\u65e0\u663e\u8457\u53d8\u5316\u3002\u4e24\u7ec4\u6539\u5584\u7a0b\u5ea6\u7684\u5dee\u5f02\u5177\u6709\u5f88\u5927\u7684\u6548\u5e94\u91cf\uff0c\u4e14\u7edf\u8ba1\u5206\u6790\u8bc1\u5b9e\u4e86\u6cbb\u7597\u4e0e\u65f6\u95f4\u4e4b\u95f4\u5b58\u5728\u663e\u8457\u7684\u4ea4\u4e92\u4f5c\u7528\uff0c\u8868\u660e\u8ba4\u77e5\u63d0\u5347\u662f\u6cbb\u7597\u5e26\u6765\u7684\u6301\u7eed\u6548\u679c\u3002<\/p>\n<section>\n<div id=\"attachment_20931\" style=\"width: 2042px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-20931\" class=\"wp-image-20931 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/\u5fae\u4fe1\u56fe\u7247_2025-12-15_113711_046.png\" alt=\"\" width=\"2032\" height=\"946\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/\u5fae\u4fe1\u56fe\u7247_2025-12-15_113711_046.png 2032w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/\u5fae\u4fe1\u56fe\u7247_2025-12-15_113711_046-300x140.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/\u5fae\u4fe1\u56fe\u7247_2025-12-15_113711_046-1024x477.png 1024w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/\u5fae\u4fe1\u56fe\u7247_2025-12-15_113711_046-768x358.png 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/\u5fae\u4fe1\u56fe\u7247_2025-12-15_113711_046-1536x715.png 1536w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/\u5fae\u4fe1\u56fe\u7247_2025-12-15_113711_046-18x8.png 18w\" sizes=\"(max-width: 2032px) 100vw, 2032px\" \/><p id=\"caption-attachment-20931\" class=\"wp-caption-text\">\u56fe2\uff1a\u8ba4\u77e5\u529f\u80fd\u8bc4\u4f30\u968f\u540e\u8fdb\u884c\u81ea\u4f53\u8840\u6db2\u5e72\u7ec6\u80de\u6cbb\u7597\u3002<\/p><\/div>\n<\/section>\n<p>\u7b2c\u4e8c\uff0c<strong>\u5728\u65e5\u5e38\u529f\u80fd\u969c\u788d\u65b9\u9762\uff0c\u6cbb\u7597\u6709\u6548\u964d\u4f4e\u4e86\u6807\u5fd7\u75c5\u60c5\u4e25\u91cd\u7684CDR-SOB\u8bc4\u5206\uff08\u56fe2B\uff09\u3002\u5b9e\u9a8c\u7ec4\u60a3\u8005\u7684CDR-SOB\u8bc4\u5206\u5728\u6cbb\u7597\u540e\u6301\u7eed\u4e0b\u964d\uff0c\u81f36\u4e2a\u6708\u65f6\u8f83\u57fa\u7ebf\u663e\u8457\u964d\u4f4e\u4e860.9\u5206\uff0c\u610f\u5473\u7740\u65e5\u5e38\u529f\u80fd\u6709\u6240\u6539\u5584<\/strong>\u3002\u800c\u5bf9\u7167\u7ec4\u8bc4\u5206\u65e0\u663e\u8457\u53d8\u5316\u3002\u6b64\u6539\u5584\u540c\u6837\u5177\u6709\u4e2d\u5230\u5927\u7684\u6548\u5e94\u91cf\uff0c\u5e76\u5f97\u5230\u7edf\u8ba1\u6a21\u578b\u7684\u663e\u8457\u652f\u6301\uff0c\u8bc1\u5b9e\u4e86\u6cbb\u7597\u5bf9\u51cf\u7f13\u529f\u80fd\u8870\u9000\u7684\u6709\u6548\u6027\u3002<\/p>\n<p>\u7b2c\u4e09\uff0c<strong>\u5728\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u6838\u5fc3\u8ba4\u77e5\u75c7\u72b6\u65b9\u9762\uff0c\u6cbb\u7597\u4f7f\u4e13\u7528\u7684ADAS-Cog\u8bc4\u5206\u663e\u8457\u4e0b\u964d\uff08\u56fe3\uff09\u3002\u5b9e\u9a8c\u7ec4\u60a3\u8005\u7684ADAS-Cog\u8bc4\u5206\u57286\u4e2a\u6708\u65f6\u8f83\u57fa\u7ebf\u5927\u5e45\u4e0b\u964d\u4e866.4\u5206\uff0c\u663e\u793a\u8bb0\u5fc6\u3001\u8bed\u8a00\u7b49\u6838\u5fc3\u8ba4\u77e5\u9886\u57df\u5f97\u5230\u6539\u5584\u3002<\/strong>\u5bf9\u7167\u7ec4\u540c\u671f\u8bc4\u5206\u5219\u7565\u6709\u4e0a\u5347\u3002\u4e24\u7ec4\u53d8\u5316\u7684\u5dee\u5f02\u540c\u6837\u5177\u6709\u5f88\u5927\u7684\u6548\u5e94\u91cf\uff0c\u7edf\u8ba1\u6a21\u578b\u518d\u6b21\u786e\u8ba4\u4e86\u6cbb\u7597\u968f\u65f6\u95f4\u7684\u663e\u8457\u76ca\u5904\uff0c\u8bc1\u660e\u4e86\u5176\u5bf9\u5ef6\u7f13\u75be\u75c5\u7279\u5f02\u6027\u8ba4\u77e5\u8870\u9000\u7684\u79ef\u6781\u4f5c\u7528\u3002<\/p>\n<h2><span 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data-pm-slice=\"0 0 []\">\u00b1 8.7%<\/span>\u300121.3%<span data-pm-slice=\"0 0 []\">\u00b16.4%<\/span>\u548c18.7%<span data-pm-slice=\"0 0 []\">\u00b17.1%<\/span>\u3002\u8fd9\u79cd\u708e\u75c7\u53cd\u5e94\u7684\u51cf\u8f7b\u4e0e\u751f\u5b58\u901a\u8def\u7684\u6fc0\u6d3b\u3001\u4ee5\u53ca\u5c0f\u80f6\u8d28\u7ec6\u80de\u6807\u5fd7\u7269Iba-1\u7684\u4e0b\u8c03\u8d8b\u52bf\u76f8\u4e00\u81f4\uff0c\u6574\u4f53\u52fe\u52d2\u51fa\u4e00\u4e2a\u4ece\u5206\u5b50\u4fe1\u53f7\u5230\u7ec6\u80de\u73af\u5883\u5168\u9762\u8f6c\u5411\u652f\u6301\u795e\u7ecf\u5143\u5b58\u6d3b\u4e0e\u529f\u80fd\u7684\u826f\u6027\u6539\u53d8\uff08\u56fe4\uff09\u3002<\/p>\n<section>\n<div id=\"attachment_20930\" style=\"width: 2042px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-20930\" class=\"wp-image-20930 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/\u5fae\u4fe1\u56fe\u7247_2025-12-15_113735_190.png\" alt=\"\" width=\"2032\" 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id=\"ADSCs%E6%B2%BB%E7%96%97%E9%98%BF%E5%B0%94%E8%8C%A8%E6%B5%B7%E9%BB%98%E7%97%85%E6%82%A3%E8%80%85%E7%9A%84%E7%A5%9E%E7%BB%8F%E5%BD%B1%E5%83%8F%E5%AD%A6%E7%BB%93%E6%9E%9C\"><\/span><strong>ADSCs\u6cbb\u7597\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u60a3\u8005\u7684\u795e\u7ecf\u5f71\u50cf\u5b66\u7ed3\u679c<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>\u6839\u636e\u795e\u7ecf\u5f71\u50cf\u5b66\u8bc4\u4f30\u7ed3\u679c\uff0c\u81ea\u4f53\u5e72\u7ec6\u80de\u6cbb\u7597\u5bf9\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u60a3\u8005\u7684\u5927\u8111\u4ea7\u751f\u4e86\u591a\u5c42\u9762\u7684\u79ef\u6781\u5f71\u54cd\uff0c\u5177\u4f53\u8868\u73b0\u5982\u4e0b\uff1a<\/p>\n<p><strong data-pm-slice=\"0 0 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class=\"ez-toc-section\" id=\"%E5%AE%89%E5%85%A8%E6%80%A7%E6%A6%82%E5%86%B5%E5%92%8C%E4%B8%8D%E8%89%AF%E4%BA%8B%E4%BB%B6\"><\/span>\u5b89\u5168\u6027\u6982\u51b5\u548c\u4e0d\u826f\u4e8b\u4ef6<span 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class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>\u672c\u7814\u7a76\u521d\u6b65\u8bc1\u5b9e\uff0cABSCs\u8054\u5408\u751f\u957f\u56e0\u5b50\u6cbb\u7597\u53ef\u80fd\u901a\u8fc7\u795e\u7ecf\u4fdd\u62a4\u4e0e\u75c7\u72b6\u6539\u5584\u53cc\u91cd\u673a\u5236\u5bf9\u4e2d\u91cd\u5ea6AD\u60a3\u8005\u4ea7\u751f\u79ef\u6781\u5f71\u54cd\u3002\u6cbb\u7597\u4e0d\u4ec5\u5728\u8ba4\u77e5\u529f\u80fd\u3001\u6dc0\u7c89\u6837\u6591\u5757\u8d1f\u8377\u53ca\u795e\u7ecf\u5f71\u50cf\u6307\u6807\u4e0a\u8868\u73b0\u51fa\u663e\u8457\u6539\u5584\uff0c\u8fd8\u53ef\u8c03\u8282\u4e0e\u795e\u7ecf\u4fdd\u62a4\u3001\u708e\u75c7\u53cd\u5e94\u76f8\u5173\u7684\u5173\u952e\u5206\u5b50\u901a\u8def\u3002<\/p>\n<p>\u8fd9\u4e9b\u53d1\u73b0\u4e3a\u957f\u671f\u4ee5\u6765\u7f3a\u4e4f\u6709\u6548\u75be\u75c5\u4fee\u9970\u6cbb\u7597\u7684AD\u63d0\u4f9b\u4e86\u4e00\u79cd\u65b0\u7684\u6f5c\u5728\u7b56\u7565\u3002\u4ee5\u4e0b\u5c06\u5c31\u673a\u5236\u3001\u4e0e\u8fd1\u671f\u7814\u7a76\u7684\u5bf9\u6bd4\u53ca\u672a\u6765\u65b9\u5411\u5c55\u5f00\u63a2\u8ba8\u3002<\/p>\n<h3 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class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u81ea\u4f53\u5e72\u7ec6\u80de\uff08ABSC\uff09\u8054\u5408\u751f\u957f\u56e0\u5b50\u6cbb\u7597\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u4e3b\u8981\u673a\u5236\u662f\u4e00\u4e2a\u591a\u9776\u70b9\u534f\u540c\u4f5c\u7528\u7684\u8fc7\u7a0b\uff0c\u53ef\u5f52\u7eb3\u4e3a\u4ee5\u4e0b\u4e09\u4e2a\u65b9\u9762\uff1a<\/p>\n<p><strong>\u9996\u5148\uff0c\u6cbb\u7597\u7684\u6838\u5fc3\u673a\u5236\u5728\u4e8e\u663e\u8457\u6fc0\u6d3b\u4e86\u7ec6\u80de\u5185\u7684\u5173\u952e\u751f\u5b58\u4e0e\u795e\u7ecf\u4fdd\u62a4\u4fe1\u53f7\u901a\u8def<\/strong>\u3002\u7814\u7a76\u8bc1\u5b9e\uff0cPI3K\/Akt\u548cMAPK\/ERK\u8fd9\u4e24\u6761\u5bf9\u795e\u7ecf\u5143\u5b58\u6d3b\u3001\u6297\u51cb\u4ea1\u53ca\u7a81\u89e6\u53ef\u5851\u6027\u81f3\u5173\u91cd\u8981\u7684\u901a\u8def\u88ab\u5f3a\u70c8\u6fc0\u6d3b\uff0c\u8868\u73b0\u4e3a\u78f7\u9178\u5316Akt\uff08p-Akt\uff09\u548c\u78f7\u9178\u5316ERK\uff08p-ERK\uff09\u6c34\u5e73\u663e\u8457\u5347\u9ad8\u3002\u8fd9\u4e9b\u901a\u8def\u7684\u6fc0\u6d3b\u5982\u540c\u542f\u52a8\u4e86\u795e\u7ecf\u5143\u5185\u90e8\u7684\u201c\u751f\u5b58\u7a0b\u5e8f\u201d\uff0c\u76f4\u63a5\u5bf9\u6297\u9000\u884c\u6027\u75c5\u53d8\uff0c\u4e3a\u540e\u7eed\u7684\u4fee\u590d\u5960\u5b9a\u5206\u5b50\u57fa\u7840\u3002<\/p>\n<p><strong>\u5176\u6b21\uff0c\u6cbb\u7597\u901a\u8fc7\u4e0a\u8c03\u5173\u952e\u795e\u7ecf\u8425\u517b\u56e0\u5b50\u5e76\u589e\u5f3a\u7a81\u89e6\u5b8c\u6574\u6027\uff0c\u76f4\u63a5\u652f\u6301\u795e\u7ecf\u4fee\u590d\u4e0e\u53ef\u5851\u6027\u3002<\/strong>\u88ab\u6fc0\u6d3b\u7684\u901a\u8def\u8fdb\u4e00\u6b65\u4fc3\u8fdb\u4e86\u8111\u6e90\u6027\u795e\u7ecf\u8425\u517b\u56e0\u5b50\uff08BDNF\uff09\u3001\u80f0\u5c9b\u7d20\u6837\u751f\u957f\u56e0\u5b50-1\uff08IGF-1\uff09\u548c\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\uff08VEGF\uff09\u7b49\u7684\u8868\u8fbe\u3002\u8fd9\u4e9b\u56e0\u5b50\u5206\u522b\u53d1\u6325\u4fc3\u8fdb\u795e\u7ecf\u5143\u5b58\u6d3b\u3001\u652f\u6301\u6d77\u9a6c\u533a\u795e\u7ecf\u751f\u957f\u4ee5\u53ca\u7ef4\u62a4\u8111\u8840\u7ba1\u5065\u5eb7\u7684\u4f5c\u7528\u3002\u540c\u65f6\uff0c\u7a81\u89e6\u6807\u5fd7\u86cb\u767d\uff08\u5982\u7a81\u89e6\u7d20\u548cPSD95\uff09\u7684\u4e0a\u8c03\uff0c\u4ece\u7ed3\u6784\u4e0a\u8bc1\u5b9e\u4e86\u7a81\u89e6\u529f\u80fd\u7684\u5f3a\u5316\uff0c\u8fd9\u5f88\u53ef\u80fd\u662f\u60a3\u8005\u8ba4\u77e5\u529f\u80fd\u83b7\u5f97\u6539\u5584\u7684\u76f4\u63a5\u7ec6\u80de\u57fa\u7840\u3002<\/p>\n<p><strong>\u6700\u540e\uff0c\u6cbb\u7597\u53d1\u6325\u4e86\u5f3a\u5927\u7684\u514d\u75ab\u8c03\u8282\u4e0e\u6297\u708e\u4f5c\u7528\uff0c\u4e3a\u5927\u8111\u521b\u9020\u4e86\u6709\u5229\u7684\u4fee\u590d\u73af\u5883\u3002<\/strong>\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u8111\u4e2d\u8fc7\u5ea6\u6d3b\u5316\u7684\u795e\u7ecf\u708e\u75c7\u4f1a\u52a0\u901f\u635f\u4f24\u3002\u672c\u7814\u7a76\u663e\u793a\uff0c\u6cbb\u7597\u540e\u4fc3\u708e\u7ec6\u80de\u56e0\u5b50\uff08\u5982TNF-\u03b1\u3001IL-6\uff09\u6c34\u5e73\u663e\u8457\u4e0b\u964d\uff0c\u540c\u65f6\u6d3b\u5316\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u7684\u6807\u5fd7\u7269GFAP\u4e5f\u660e\u663e\u51cf\u5c11\u3002\u8fd9\u8868\u660e\u5e72\u7ec6\u80de\u7597\u6cd5\u6709\u6548\u6291\u5236\u4e86\u6709\u5bb3\u7684\u795e\u7ecf\u708e\u75c7\u53cd\u5e94\uff0c\u51cf\u8f7b\u4e86\u708e\u75c7\u5bf9\u795e\u7ecf\u5143\u7684\u6301\u7eed\u653b\u51fb\uff0c\u4ece\u800c\u95f4\u63a5\u4fdd\u62a4\u4e86\u8111\u7ec4\u7ec7\u3002<\/p>\n<p>\u7efc\u4e0a\u6240\u8ff0\uff0c\u8be5\u7597\u6cd5\u901a\u8fc7\u201c\u6fc0\u6d3b\u751f\u5b58\u4fe1\u53f7-\u63d0\u4f9b\u8425\u517b\u652f\u6301-\u6291\u5236\u6709\u5bb3\u708e\u75c7\u201d\u4e09\u4f4d\u4e00\u4f53\u7684\u534f\u540c\u673a\u5236\uff0c\u5171\u540c\u51cf\u7f13\u795e\u7ecf\u53d8\u6027\u3001\u4fc3\u8fdb\u4fee\u590d\uff0c\u6700\u7ec8\u5b9e\u73b0\u4e86\u5ef6\u7f13\u75be\u75c5\u8fdb\u5c55\u548c\u6539\u5584\u8ba4\u77e5\u529f\u80fd\u7684\u6548\u679c\u3002<\/p>\n<section data-role=\"paragraph\">\n<h2><span class=\"ez-toc-section\" id=\"%E7%BB%93%E8%AE%BA%E4%B8%8E%E5%B1%95%E6%9C%9B\"><\/span><strong>\u7ed3\u8bba\u4e0e\u5c55\u671b<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>\u8fd9\u9879\u4e34\u5e8a\u8bd5\u9a8c\u8bc1\u5b9e\u4e86\u5c06\u81ea\u4f53\u5e72\u7ec6\u80de\uff08ABSC\uff09\u4e0e\u751f\u957f\u56e0\u5b50\u8054\u5408\u7528\u4e8e\u6cbb\u7597\u4e2d\u91cd\u5ea6\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\uff08AD\uff09\u60a3\u8005\u7684\u7597\u6548\u3002<\/p>\n<p>\u8be5\u7597\u6cd5\u663e\u8457\u6539\u5584\u4e86\u60a3\u8005\u7684\u8ba4\u77e5\u529f\u80fd\uff0c\u51cf\u5c11\u4e86\u6dc0\u7c89\u6837\u6591\u5757\u8d1f\u8377\uff0c\u5e76\u6539\u5584\u4e86\u795e\u7ecf\u5f71\u50cf\u5b66\u7ed3\u679c\uff0c\u8868\u660e\u8fd9\u79cd\u65b0\u578b\u7597\u6cd5\u4e0d\u4ec5\u80fd\u591f\u7f13\u89e3\u75c7\u72b6\uff0c\u8fd8\u80fd\u6539\u53d8\u6f5c\u5728\u7684\u75be\u75c5\u8fdb\u7a0b\u3002\u5173\u952e\u5206\u5b50\u901a\u8def\uff0c\u4f8b\u5982PI3K\/Akt\u548cMAPK\/ERK\u901a\u8def\uff0c\u5f97\u5230\u4e86\u6709\u5229\u7684\u8c03\u8282\uff0c\u4ece\u800c\u4fc3\u8fdb\u4e86\u795e\u7ecf\u5143\u5b58\u6d3b\u3001\u795e\u7ecf\u4fdd\u62a4\u548c\u795e\u7ecf\u53ef\u5851\u6027\u3002\u8fd9\u4e9b\u53d1\u73b0\u51f8\u663e\u4e86\u8be5\u7597\u6cd5\u9776\u5411\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u591a\u79cd\u673a\u5236\u4ee5\u5b9e\u73b0\u5168\u9762\u6cbb\u7597\u83b7\u76ca\u7684\u6f5c\u529b\u3002<\/p>\n<p>\u7814\u7a76\u4e2d\u672a\u51fa\u73b0\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\uff0c\u63d0\u793a\u8be5\u8054\u5408\u65b9\u6848\u8010\u53d7\u6027\u826f\u597d\uff0c\u5177\u5907\u8fdb\u4e00\u6b65\u4e34\u5e8a\u63a8\u5e7f\u7684\u5b89\u5168\u6027\u57fa\u7840\u3002\u672a\u6765\u9700\u5f00\u5c55\u66f4\u5927\u6837\u672c\u3001\u591a\u4e2d\u5fc3\u3001\u957f\u671f\u968f\u8bbf\u7684\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\uff0c\u4ee5\u9a8c\u8bc1\u5176\u6301\u4e45\u7597\u6548\u4e0e\u75be\u75c5\u4fee\u9970\u4f5c\u7528\uff0c\u5e76\u63a2\u7d22\u6700\u4f73\u6cbb\u7597\u65f6\u673a\u3001\u5242\u91cf\u53ca\u4eba\u7fa4\u5206\u5c42\u7b56\u7565\u3002<\/p>\n<blockquote>\n<p data-pm-slice=\"0 0 []\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u53c2\u8003\u8d44\u6599\uff1a[1] <\/span><\/span><span data-pm-slice=\"0 0 []\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">Lee, WJ, Cho, K., Lee, D.\u00a0 <\/span><\/span><\/span><i><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">et al.<\/span><\/span><\/i><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u00a0\u81ea\u4f53\u8840\u6db2\u5e72\u7ec6\u80de\u8054\u5408\u751f\u957f\u56e0\u5b50\u6cbb\u7597\u4e2d\u91cd\u5ea6\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7597\u6548\uff1a\u4e00\u9879\u4e34\u5e8a\u8bd5\u9a8c\u3002Mol\u00a0 <\/span><\/span><i><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">Neurobiol <\/span><\/span><\/i>\u00a0<b><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">63<\/span><\/span><\/b><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> , 277 (2026). https:\/\/doi.org\/10.1007\/s12035-025-05583-0<\/span><\/span><\/p>\n<p>\u514d\u8d23\u8bf4\u660e\uff1a\u672c\u6587\u4ec5\u7528\u4e8e\u4f20\u64ad\u79d1\u666e\u77e5\u8bc6\uff0c\u5206\u4eab\u884c\u4e1a\u89c2\u70b9\uff0c\u4e0d\u6784\u6210\u4efb\u4f55\u4e34\u5e8a\u8bca\u65ad\u5efa\u8bae\uff01\u676d\u5409\u5e72\u7ec6\u80de\u6240\u53d1\u5e03\u7684\u4fe1\u606f\u4e0d\u80fd\u66ff\u4ee3\u533b\u751f\u6216\u836f\u5242\u5e08\u7684\u4e13\u4e1a\u5efa\u8bae\u3002\u5982\u6709\u7248\u6743\u7b49\u7591\u95ee\uff0c\u8bf7\u968f\u65f6\u8054\u7cfb\u6211\u3002<\/p><\/blockquote>\n<\/section>","protected":false},"excerpt":{"rendered":"<p>\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\uff08AD\uff09\u7684\u7279\u5f81\u662f\u8fdb\u884c\u6027\u8ba4\u77e5\u529f\u80fd\u4e0b\u964d\u3001\u8bb0\u5fc6\u529b\u51cf\u9000\u53ca\u65e5\u5e38\u751f\u6d3b\u80fd\u529b\u4e27\u5931\u3002\u5c3d\u7ba1\u5df2\u6709\u5927\u91cf\u7814\u7a76\uff0c\u76ee\u524d\u4ecd\u7f3a\u4e4f\u80fd\u591f [&hellip;]<\/p>","protected":false},"author":1,"featured_media":20927,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[76],"tags":[150,198,254],"_links":{"self":[{"href":"https:\/\/www.hjtdsm.cn\/ar\/wp-json\/wp\/v2\/posts\/20926"}],"collection":[{"href":"https:\/\/www.hjtdsm.cn\/ar\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hjtdsm.cn\/ar\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/ar\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/ar\/wp-json\/wp\/v2\/comments?post=20926"}],"version-history":[{"count":2,"href":"https:\/\/www.hjtdsm.cn\/ar\/wp-json\/wp\/v2\/posts\/20926\/revisions"}],"predecessor-version":[{"id":20936,"href":"https:\/\/www.hjtdsm.cn\/ar\/wp-json\/wp\/v2\/posts\/20926\/revisions\/20936"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/ar\/wp-json\/wp\/v2\/media\/20927"}],"wp:attachment":[{"href":"https:\/\/www.hjtdsm.cn\/ar\/wp-json\/wp\/v2\/media?parent=20926"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/ar\/wp-json\/wp\/v2\/categories?post=20926"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/ar\/wp-json\/wp\/v2\/tags?post=20926"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}