{"id":21107,"date":"2025-12-24T15:09:10","date_gmt":"2025-12-24T07:09:10","guid":{"rendered":"https:\/\/www.hjtdsm.cn\/?p=21107"},"modified":"2025-12-24T15:09:39","modified_gmt":"2025-12-24T07:09:39","slug":"https-www-hjtdsm-cn-stem-cells-stem-cell-therapy-21107-html","status":"publish","type":"post","link":"https:\/\/www.hjtdsm.cn\/ar\/stem-cells\/stem-cell-therapy\/21107.html","title":{"rendered":"\u79bbIII\u671f\u4e34\u5e8a\u66f4\u8fd1\u4e00\u6b65\uff01\u81ea\u4f53\u5e72\u7ec6\u80de\u6cbb\u7597\u7279\u5e94\u6027\u76ae\u708e\u7684II\u671f\u8bd5\u9a8c\u8bc1\u5b9e\uff0c\u53ef\u663e\u8457\u6539\u5584\u5176\u75c7\u72b6"},"content":{"rendered":"<section data-role=\"paragraph\">\u7279\u5e94\u6027\u76ae\u708e\uff08AD\uff09\u662f\u4e00\u79cd\u6162\u6027\u708e\u75c7\u6027\u76ae\u80a4\u75c5\uff0c\u4e25\u91cd\u5f71\u54cd\u60a3\u8005\u751f\u6d3b\u8d28\u91cf\uff0c\u800c\u73b0\u6709\u4f20\u7edf\u7597\u6cd5\u4ecd\u5b58\u5728\u4e00\u5b9a\u5c40\u9650\u6027\u3002\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6cbb\u7597\u7279\u5e94\u6027\u76ae\u708e\u63d0\u4f9b\u4e86\u65b0\u7684\u53ef\u80fd\uff0c\u4f46\u5176\u5927\u89c4\u6a21\u4e34\u5e8a\u5e94\u7528\u7684\u6709\u6548\u6027\u4e0e\u5b89\u5168\u6027\u5c1a\u9700\u66f4\u591a\u8bc1\u636e\u652f\u6301\u3002<\/p>\n<h2><span class=\"ez-toc-section\" 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href=\"https:\/\/link.springer.com\/article\/10.1186\/s13287-025-04763-y#citeas\" target=\"_blank\" rel=\"noopener nofollow\">\u201c\u81ea\u4f53\u8102\u80aa\u5e72\u7ec6\u80de\u6cbb\u7597\u4e2d\u91cd\u5ea6\u7279\u5e94\u6027\u76ae\u708e\u60a3\u8005\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\uff1a\u4e00\u9879\u591a\u4e2d\u5fc3\u3001\u968f\u673a\u3001\u5355\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u7684II\u671f\u8bd5\u9a8c\u201d<\/a>\u7684\u7814\u7a76\u8bba\u6587[1]\u3002<\/p>\n<section><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-21113 aligncenter\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-24_113540_430.png\" alt=\"\" width=\"811\" height=\"485\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-24_113540_430.png 811w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-24_113540_430-300x179.png 300w, 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class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>\u7279\u5e94\u6027\u76ae\u708e\u662f\u4e00\u79cd\u4ee5\u5267\u70c8\u7619\u75d2\u3001\u53cd\u590d\u53d1\u4f5c\u4e3a\u7279\u5f81\u7684\u6162\u6027\u708e\u75c7\u6027\u76ae\u80a4\u75c5\u3002\u7814\u7a76\u663e\u793a\uff0c\u4e2d\u91cd\u5ea6AD\u9664\u76ae\u80a4\u8868\u73b0\u5916\uff0c\u8fd8\u4f1a\u663e\u8457\u5f71\u54cd\u60a3\u8005\u7684\u60c5\u7eea\u548c\u5fc3\u7406\u5065\u5eb7\u3002\u8be5\u75c5\u5728\u513f\u7ae5\u4e2d\u7684\u7ec8\u751f\u60a3\u75c5\u7387\u8fbe10%\uff5e20%\uff0c\u5728\u6210\u4eba\u4e2d\u7ea6\u4e3a3%\uff5e7%\uff0c\u5df2\u6210\u4e3a\u5168\u7403\u516c\u5171\u536b\u751f\u7684\u91cd\u8981\u8d1f\u62c5\u3002<\/p>\n<section><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-21108 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/istockphoto-1433243042-612x612-1.jpg\" alt=\"\u79bbIII\u671f\u4e34\u5e8a\u66f4\u8fd1\u4e00\u6b65\uff01\u81ea\u4f53\u5e72\u7ec6\u80de\u6cbb\u7597\u7279\u5e94\u6027\u76ae\u708e\u7684II\u671f\u8bd5\u9a8c\u8bc1\u5b9e\uff0c\u53ef\u663e\u8457\u6539\u5584\u5176\u75c7\u72b6\" width=\"612\" height=\"408\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/istockphoto-1433243042-612x612-1.jpg 612w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/istockphoto-1433243042-612x612-1-300x200.jpg 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/istockphoto-1433243042-612x612-1-18x12.jpg 18w\" sizes=\"(max-width: 612px) 100vw, 612px\" \/><\/section>\n<p>AD\u7684\u6cbb\u7597\u9009\u62e9\u4f9d\u4e25\u91cd\u7a0b\u5ea6\u800c\u5f02\uff0c\u4e2d\u91cd\u5ea6\u60a3\u8005\u5e38\u9700\u4f7f\u7528\u5168\u8eab\u6027\u514d\u75ab\u6291\u5236\u5242\uff0c\u5982\u7cd6\u76ae\u8d28\u6fc0\u7d20\u3001\u73af\u5b62\u7d20\u53caJAK\u6291\u5236\u5242\u7b49\uff0c\u4f46\u957f\u671f\u5e94\u7528\u53ef\u80fd\u5e26\u6765\u660e\u663e\u526f\u4f5c\u7528\u4e0e\u6bd2\u6027\u98ce\u9669\u3002\u8fd1\u5e74\u6765\uff0c\u9488\u5bf9\u7279\u5b9a\u7ec6\u80de\u56e0\u5b50\uff08\u5982IL-4\/13\u3001IL-13\u3001IL-31\uff09\u7684\u751f\u7269\u5236\u5242\u4e3a\u90e8\u5206\u60a3\u8005\u5e26\u6765\u65b0\u5e0c\u671b\uff0c\u7136\u800c\u4ecd\u6709\u76f8\u5f53\u6bd4\u4f8b\u60a3\u8005\u65e0\u6cd5\u5b9e\u73b0\u5b8c\u5168\u6216\u957f\u671f\u7f13\u89e3\u3002<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%E9%97%B4%E5%85%85%E8%B4%A8%E5%B9%B2%E7%BB%86%E8%83%9E%E7%9A%84%E6%B2%BB%E7%96%97%E6%BD%9C%E5%8A%9B\"><\/span><strong>\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u7684\u6cbb\u7597\u6f5c\u529b<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><a href=\"https:\/\/www.hjtdsm.cn\/ar\/stem-cells\/mscs\/20558.html\/\" target=\"_blank\" rel=\"noopener\">\u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062c\u0630\u0639\u064a\u0629 \u0627\u0644\u0648\u0633\u064a\u0637\u0629 \u0627\u0644\u0648\u0633\u064a\u0637\u0629 MSC (\u0641\u064a \u0628\u064a\u0648\u0644\u0648\u062c\u064a\u0627 \u0627\u0644\u062e\u0644\u064a\u0629)<\/a>\u662f\u4e00\u7c7b\u5177\u6709\u591a\u5411\u5206\u5316\u6f5c\u80fd\u7684\u5e72\u7ec6\u80de\uff0c\u53ef\u4ece<a href=\"https:\/\/www.hjtdsm.cn\/ar\/stem-cells\/mscs\/19975.html\/\" target=\"_blank\" rel=\"noopener\">\u8110\u5e26<\/a>\u3001\u9aa8\u9ad3\u3001\u8102\u80aa\u7b49\u591a\u79cd\u7ec4\u7ec7\u4e2d\u83b7\u53d6\u3002\u5176\u8868\u9762\u8868\u8fbeCD73\u3001CD90\u3001CD105\u7b49\u6807\u5fd7\u7269\uff0c\u4e0d\u8868\u8fbe\u9020\u8840\u7cfb\u6807\u5fd7\u7269\u5982CD45\u3001CD34\u7b49\u3002<\/p>\n<p>MSCs\u5728\u6297\u708e\u3001\u7ec4\u7ec7\u4fee\u590d\u53ca\u514d\u75ab\u8c03\u8282\u4e2d\u53d1\u6325\u5173\u952e\u4f5c\u7528\uff0c\u80fd\u591f\u901a\u8fc7\u4e0e\u5148\u5929\u6027\u548c\u9002\u5e94\u6027\u514d\u75ab\u7cfb\u7edf\u7684\u4e92\u52a8\uff0c\u6291\u5236T\u7ec6\u80de\u3001B\u7ec6\u80de\u3001\u6811\u7a81\u72b6\u7ec6\u80de\u53ca\u81ea\u7136\u6740\u4f24\u7ec6\u80de\u7b49\u7684\u8fc7\u5ea6\u6d3b\u5316\u3002\u52a8\u7269\u5b9e\u9a8c\u8868\u660e\uff0cMSCs\u5bf9\u7279\u5e94\u6027\u76ae\u708e\u3001\u54ee\u5598\u7b49\u8fc7\u654f\u6027\u75be\u75c5\u5177\u6709\u6539\u5584\u6f5c\u529b\uff0c\u8fd9\u4e9b\u7279\u6027\u4f7f\u5176\u6210\u4e3a\u6cbb\u7597AD\u7b49\u514d\u75ab\u76f8\u5173\u75be\u75c5\u7684\u6709\u524d\u666f\u7b56\u7565\u3002<\/p>\n<p>\u5c3d\u7ba1\u5df2\u6709\u82e5\u5e72\u4e34\u5e8a\u8bd5\u9a8c\u63a2\u8ba8MSCs\u6cbb\u7597AD\u7684\u6548\u679c\uff0c\u4f46\u5176\u5728\u5927\u89c4\u6a21\u4eba\u7fa4\u4e2d\u7684\u7597\u6548\u4e0e\u5b89\u5168\u6027\u8bc1\u636e\u4ecd\u4e0d\u5145\u5206\u3002\u4e3a\u6b64\uff0c\u7814\u7a76\u56e2\u961f\u5f00\u5c55\u4e86\u4e00\u9879\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u65e8\u5728\u8bc4\u4f30AtMSC\u6cbb\u7597\u5bf9114\u4f8b\u5e38\u89c4\u6cbb\u7597\u65e0\u6548\u7684\u4e2d\u91cd\u5ea6AD\u6210\u4eba\u60a3\u8005\u7684\u7597\u6548\u4e0e\u5b89\u5168\u6027\uff0c\u5e76\u901a\u8fc7\u68c0\u6d4b\u8840\u6e05\u7ec6\u80de\u56e0\u5b50\u6c34\u5e73\u8fdb\u4e00\u6b65\u63a2\u7d22\u5176\u4f5c\u7528\u673a\u5236\u3002<\/p>\n<h3 data-test=\"abstract-sub-heading\"><span class=\"ez-toc-section\" id=\"%E7%A0%94%E7%A9%B6%E6%96%B9%E6%B3%95\"><\/span><strong>\u7814\u7a76\u65b9\u6cd5<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p data-test=\"abstract-sub-heading\">\u672c\u7814\u7a76\u4e3a\u4e00\u9879\u591a\u4e2d\u5fc3\u3001\u968f\u673a\u3001\u5355\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u7684II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002\u5171\u7eb3\u5165114\u4f8b\u53d7\u8bd5\u8005\uff0c\u968f\u673a\u5206\u914d\u81f3\u6cbb\u7597\u7ec4\u4e0e\u5b89\u6170\u5242\u7ec4\uff0c\u5206\u522b\u63a5\u53d7\u4e24\u6b21\u9759\u8109\u8f93\u6ce8\uff08\u95f4\u96944\u5468\uff09\u3002<\/p>\n<\/section>\n<section data-role=\"paragraph\">\n<p data-test=\"abstract-sub-heading\">\u6cbb\u7597\u671f\u95f4\uff0c\u6bcf4\u5468\u8fdb\u884c\u4e00\u6b21\u4e34\u5e8a\u8bc4\u4f30\uff0c\u4e3b\u8981\u6307\u6807\u5305\u62ec\u6e7f\u75b9\u9762\u79ef\u4e0e\u4e25\u91cd\u7a0b\u5ea6\u6307\u6570\uff08EASI\uff09\u3001\u7279\u5e94\u6027\u76ae\u708e\u8bc4\u5206\uff08SCORAD\uff09\u548c\u7814\u7a76\u8005\u603b\u4f53\u8bc4\u4f30\uff08IGA\uff09\uff0c\u603b\u968f\u8bbf\u65f6\u95f4\u4e3a16\u5468\u3002\u540c\u65f6\uff0c\u91c7\u7528\u9176\u8054\u514d\u75ab\u5438\u9644\u8bd5\u9a8c\uff08ELISA\uff09\u5bf9\u8840\u6e05\u4e2d\u591a\u79cd\u7ec6\u80de\u56e0\u5b50\u8fdb\u884c\u5b9a\u91cf\u5206\u6790\u3002<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%E7%BB%93%E6%9E%9C\"><\/span><strong>\u7ed3\u679c<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<h3><span class=\"ez-toc-section\" id=\"%E5%8F%97%E8%AF%95%E8%80%85%E5%9F%BA%E7%BA%BF%E7%89%B9%E5%BE%81\"><\/span>\u53d7\u8bd5\u8005\u57fa\u7ebf\u7279\u5f81<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<\/section>\n<section data-role=\"paragraph\">\u56fe1\u603b\u7ed3\u4e86\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u7814\u7a76\u5bf9\u8c61\u7684\u5206\u5e03\u60c5\u51b5\u3002\u672c\u7814\u7a76\u5171\u7eb3\u5165114\u540d\u53d7\u8bd5\u8005\uff0c\u5176\u5e73\u5747\u5e74\u9f84\u4e3a31.21\u5c81\uff08\u6807\u51c6\u5dee10.74\u5c81\uff09\uff0c\u6027\u522b\u5206\u5e03\u4ee5\u7537\u6027\u4e3a\u4e3b\uff0c\u517182\u4f8b\uff0871.9%\uff09\uff0c\u5973\u602732\u4f8b\uff0828.1%\uff09\u3002<\/section>\n<section data-role=\"paragraph\">\n<section>\n<div id=\"attachment_21112\" style=\"width: 695px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-21112\" class=\"wp-image-21112 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/\u5fae\u4fe1\u56fe\u7247_2025-12-24_113610_551.png\" alt=\"\" width=\"685\" height=\"253\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/\u5fae\u4fe1\u56fe\u7247_2025-12-24_113610_551.png 685w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/\u5fae\u4fe1\u56fe\u7247_2025-12-24_113610_551-300x111.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/\u5fae\u4fe1\u56fe\u7247_2025-12-24_113610_551-18x7.png 18w\" sizes=\"(max-width: 685px) 100vw, 685px\" \/><p id=\"caption-attachment-21112\" class=\"wp-caption-text\">\u56fe1\uff1a\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u7814\u7a76\u5bf9\u8c61\u5904\u7f6e\u60c5\u51b5\u6982\u8ff0\u3002<\/p><\/div>\n<\/section>\n<\/section>\n<section data-role=\"paragraph\">\u53d7\u8bd5\u8005\u7684\u5e73\u5747\u8eab\u9ad8\u548c\u4f53\u91cd\u5206\u522b\u4e3a169.18\u5398\u7c73\uff08\u6807\u51c6\u5dee8.34\u5398\u7c73\uff09\u548c72.43\u516c\u65a4\uff08\u6807\u51c6\u5dee15.00\u516c\u65a4\uff09\u3002\u8fd9\u4e9b\u57fa\u672c\u4eba\u53e3\u7edf\u8ba1\u5b66\u7279\u5f81\u53ca\u57fa\u7ebf\u6307\u6807\u5728\u6cbb\u7597\u7ec4\u4e0e\u5b89\u6170\u5242\u7ec4\u4e4b\u95f4\u5747\u65e0\u7edf\u8ba1\u5b66\u5dee\u5f02\uff08\u88681\uff09\uff0c\u8868\u660e\u5404\u7ec4\u5728\u8bd5\u9a8c\u8d77\u59cb\u9636\u6bb5\u5177\u6709\u826f\u597d\u53ef\u6bd4\u6027\uff0c\u4e3a\u540e\u7eed\u7597\u6548\u5206\u6790\u63d0\u4f9b\u4e86\u5747\u8861\u57fa\u7840\u3002<\/p>\n<section>\n<div id=\"attachment_21111\" style=\"width: 846px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-21111\" class=\"wp-image-21111 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-24_113652_495.png\" alt=\"\" width=\"836\" height=\"821\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-24_113652_495.png 836w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-24_113652_495-300x295.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-24_113652_495-768x754.png 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-24_113652_495-12x12.png 12w\" sizes=\"(max-width: 836px) 100vw, 836px\" \/><p id=\"caption-attachment-21111\" class=\"wp-caption-text\">\u88681\uff1a\u4eba\u53e3\u7edf\u8ba1\u4fe1\u606f\uff08\u5b8c\u6574\u5206\u6790\u96c6\uff09<\/p><\/div>\n<\/section>\n<p>\u5728\u5408\u5e76\u75c7\u65b9\u9762\uff0c\u53d7\u8bd5\u8005\u4e2d\u4ee5\u87a8\u866b\u8fc7\u654f\u6700\u4e3a\u5e38\u89c1\uff0c\u517135\u4f8b\uff0830.7%\uff09\uff0c\u5176\u4e2d\u6cbb\u7597\u7ec420\u4f8b\uff08\u5360\u8be5\u7ec433.9%\uff09\uff0c\u5b89\u6170\u5242\u7ec415\u4f8b\uff08\u5360\u8be5\u7ec427.3%\uff09\u3002\u5176\u6b21\u4e3a\u52a8\u7269\u8fc7\u654f20\u4f8b\uff0817.5%\uff09\uff0c\u6cbb\u7597\u7ec413\u4f8b\uff0822.0%\uff09\uff0c\u5b89\u6170\u5242\u7ec47\u4f8b\uff0812.7%\uff09\uff1b\u8fc7\u654f\u6027\u9f3b\u708e16\u4f8b\uff0814.0%\uff09\uff0c\u6cbb\u7597\u7ec4\u4e0e\u5b89\u6170\u5242\u7ec4\u54048\u4f8b\u3002\u5176\u4ed6\u75be\u75c5\u4fe1\u606f\u8be6\u89c1\u8865\u5145\u6750\u6599\uff0c\u6574\u4f53\u5408\u5e76\u75c7\u5206\u5e03\u53cd\u6620\u4e86\u53d7\u8bd5\u7fa4\u4f53\u4e2d\u8fc7\u654f\u6027\u75be\u75c5\u8f83\u4e3a\u666e\u904d\u3002<\/p>\n<section>\n<h3><span class=\"ez-toc-section\" id=\"%E4%B8%B4%E5%BA%8A%E7%96%97%E6%95%88%E7%BB%93%E6%9E%9C\"><\/span>\u4e34\u5e8a\u7597\u6548\u7ed3\u679c<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<\/section>\n<section><strong>EASI\u8bc4\u5206\u7684\u6301\u7eed\u6027\u6539\u5584\uff1a<\/strong>\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0c\u5728\u6cbb\u7597\u521d\u671f\uff08\u7b2c4\u5468\uff09\uff0c\u6cbb\u7597\u7ec4\u4e0e\u5b89\u6170\u5242\u7ec4\u7684\u6e7f\u75b9\u9762\u79ef\u4e0e\u4e25\u91cd\u7a0b\u5ea6\u6307\u6570\uff08EASI\uff09\u603b\u5206\u5e73\u5747\u4e0b\u964d\u5e45\u5ea6\u5747\u8f83\u5c0f\uff0c\u4e14\u65e0\u7edf\u8ba1\u5b66\u5dee\u5f02\u3002\u4f46\u4ece\u7b2c8\u5468\u5f00\u59cb\uff0c\u6cbb\u7597\u7ec4\u7684EASI\u603b\u5206\u6539\u5584\u6301\u7eed\u52a0\u5927\uff0c\u4ece-3.48\u7a33\u6b65\u6269\u5927\u81f3-9.26\uff0c\u800c\u5b89\u6170\u5242\u7ec4\u7684\u6539\u5584\u975e\u5e38\u6709\u9650\uff08\u4ec5\u4e3a-2.54\uff09\u3002\u4e24\u7ec4\u5728\u7b2c8\u300112\u548c16\u5468\u7684\u6539\u5584\u5dee\u5f02\u5747\u5177\u6709\u7edf\u8ba1\u5b66\u610f\u4e49\uff0c\u8868\u660e\u6cbb\u7597\u836f\u7269\u968f\u65f6\u95f4\u63a8\u79fb\u80fd\u663e\u8457\u51cf\u8f7b\u6e7f\u75b9\u7684\u4e25\u91cd\u7a0b\u5ea6<span dir=\"auto\" data-pm-slice=\"0 0 []\">\uff08\u56fe2\uff09<\/span>\u3002<\/section>\n<section>\n<section>\n<div id=\"attachment_21110\" style=\"width: 1900px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-21110\" class=\"wp-image-21110 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/\u5fae\u4fe1\u56fe\u7247_2025-12-24_113722_053.png\" alt=\"\" width=\"1890\" height=\"1043\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/\u5fae\u4fe1\u56fe\u7247_2025-12-24_113722_053.png 1890w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/\u5fae\u4fe1\u56fe\u7247_2025-12-24_113722_053-300x166.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/\u5fae\u4fe1\u56fe\u7247_2025-12-24_113722_053-1024x565.png 1024w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/\u5fae\u4fe1\u56fe\u7247_2025-12-24_113722_053-768x424.png 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/\u5fae\u4fe1\u56fe\u7247_2025-12-24_113722_053-1536x848.png 1536w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/\u5fae\u4fe1\u56fe\u7247_2025-12-24_113722_053-18x10.png 18w\" sizes=\"(max-width: 1890px) 100vw, 1890px\" \/><p id=\"caption-attachment-21110\" class=\"wp-caption-text\">\u56fe2\uff1aaEASI\u603b\u5206\u5e73\u5747\u53d8\u5316\u503c\uff0cb\u8fbe\u5230EASI-50\u7684\u53c2\u4e0e\u8005\u767e\u5206\u6bd4\uff0cc\u8fbe\u5230 EASI-75\u7684\u53c2\u4e0e\u8005\u767e\u5206\u6bd4\uff0cdSCORAD\u603b\u5206\u964d\u4f4e50%\u6216\u4ee5\u4e0a\u7684\u53c2\u4e0e\u8005\u767e\u5206\u6bd4\uff08SCORAD-50\uff09\uff0ce\u75be\u75c5\u4e25\u91cd\u7a0b\u5ea6\u5e73\u5747\u53d8\u5316\u503c\uff0cfIGA\u8bc4\u5206\u5e73\u5747\u53d8\u5316\u503c\u2014\u2014\u6240\u6709\u6307\u6807\u5747\u4ee5\u5404\u65f6\u95f4\u70b9\u7684\u57fa\u7ebf\u4e3a\u57fa\u51c6\u8fdb\u884c\u6d4b\u91cf<\/p><\/div>\n<\/section>\n<\/section>\n<section><strong>\u9ad8\u6bd4\u4f8b\u7684\u5e94\u7b54\u8fbe\u6807\u7387\uff1a<\/strong>\u5728\u6cbb\u7597\u53cd\u5e94\u7387\u65b9\u9762\uff0c\u65e9\u671f\uff08\u7b2c4\u81f312\u5468\uff09\u8fbe\u5230EASI-50\uff08\u5373\u75c7\u72b6\u6539\u558450%\u4ee5\u4e0a\uff09\u7684\u60a3\u8005\u6bd4\u4f8b\u5728\u4e24\u7ec4\u95f4\u65e0\u663e\u8457\u5dee\u5f02\u3002\u7136\u800c\u81f3\u7b2c16\u5468\uff0c\u6cbb\u7597\u7ec4\u670950.9%\u7684\u60a3\u8005\u8fbe\u5230EASI-50\uff0c\u663e\u8457\u9ad8\u4e8e\u5b89\u6170\u5242\u7ec4\u768414.6%\uff08P&lt;0.001\uff09\uff0c\u4e24\u7ec4\u5dee\u503c\u8fbe36.3%\u3002\u540c\u6837\uff0c\u8fbe\u5230\u66f4\u9ad8\u6807\u51c6EASI-75\u7684\u60a3\u8005\u6bd4\u4f8b\u5728\u7b2c16\u5468\u65f6\uff0c\u6cbb\u7597\u7ec4\uff0823.7%\uff09\u4e5f\u663e\u8457\u9ad8\u4e8e\u5b89\u6170\u5242\u7ec4\uff087.3%\uff09\uff0c\u663e\u793a\u6cbb\u7597\u836f\u7269\u5728\u957f\u671f\u5e94\u7528\u4e2d\u80fd\u663e\u8457\u63d0\u5347\u6df1\u5ea6\u7f13\u89e3\u7684\u60a3\u8005\u6bd4\u4f8b\uff08\u56fe2b\uff09\u3002\u6b64\u5916\uff0c\u5176\u4ed6\u8bc4\u4f30\u6307\u6807\u4e5f\u5448\u73b0\u4e00\u81f4\u8d8b\u52bf\u3002SCORAD\u8bc4\u5206\u968f\u65f6\u95f4\u6539\u5584\u7684\u6a21\u5f0f\u4e0eEASI\u8bc4\u5206\u76f8\u4f3c\uff0c\u4f46\u672a\u89c2\u5bdf\u5230\u8bc4\u5206\u964d\u4f4e75%\u4ee5\u4e0a\u7684\u6bd4\u4f8b\u3002\u5728\u75be\u75c5\u603b\u4f53\u4e25\u91cd\u7a0b\u5ea6\u548c\u7814\u7a76\u8005\u6574\u4f53\u8bc4\u4f30\uff08IGA\uff09\u8bc4\u5206\u65b9\u9762\uff0c\u6cbb\u7597\u7ec4\u76f8\u6bd4\u5b89\u6170\u5242\u7ec4\u4e5f\u663e\u793a\u51fa\u66f4\u5177\u4f18\u52bf\u7684\u6539\u5584\uff0c\u8fdb\u4e00\u6b65\u9a8c\u8bc1\u4e86\u6cbb\u7597\u836f\u7269\u5bf9\u7279\u5e94\u6027\u76ae\u708e\u7684\u5168\u9762\u7597\u6548\uff08\u56fe2c\uff09\u3002<\/p>\n<p data-path-to-node=\"5\" data-pm-slice=\"0 0 []\"><strong>\u591a\u7ef4\u5ea6\u7684\u75be\u75c5\u63a7\u5236\u6548\u679c\uff1a<\/strong>\u9664EASI\u8bc4\u5206\u5916\uff0c\u8be5\u7597\u6cd5\u5bf9\u60a3\u8005\u75c5\u60c5\u7684\u6539\u5584\u662f<b data-path-to-node=\"6\" data-index-in-node=\"21\">\u5168\u65b9\u4f4d<\/b>\u7684\u3002<\/p>\n<ul class=\"list-paddingleft-1\">\n<li>\n<p data-path-to-node=\"10,0,0\"><b data-path-to-node=\"10,0,0\" data-index-in-node=\"0\">SCORAD\u8bc4\u5206\uff1a<\/b>\u53d8\u5316\u8d8b\u52bf\u4e0eEASI\u9ad8\u5ea6\u540c\u6b65\uff08\u56fe2d\uff09\uff0c\u8bc1\u660e\u4e86\u7597\u6548\u5728\u4e0d\u540c\u8bc4\u4ef7\u4f53\u7cfb\u4e0b\u7684\u4e00\u81f4\u6027\u3002<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"10,1,0\"><b data-path-to-node=\"10,1,0\" data-index-in-node=\"0\">IGA\u8bc4\u5206\u4e0e\u4e25\u91cd\u7a0b\u5ea6\uff1a<\/b>\u6cbb\u7597\u7ec4\u5728\u7814\u7a76\u8005\u5168\u7403\u8bc4\u4f30\uff08IGA\uff09\u53ca\u6574\u4f53\u75be\u75c5\u4e25\u91cd\u7a0b\u5ea6\u5206\u7ea7\u4e0a\u5747\u4f18\u4e8e\u5b89\u6170\u5242\uff08\u56fe2e-f\uff09\u3002<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"10,2,0\"><b data-path-to-node=\"10,2,0\" data-index-in-node=\"0\">\u5c40\u9650\u6027\u89c2\u5bdf\uff1a<\/b>\u5c3d\u7ba1\u591a\u9879\u6307\u6807\u5411\u597d\uff0c\u4f46\u4e24\u7ec4\u5728SCORAD75%\u6539\u5584\uff08SCORAD-75\uff09\u8fd9\u4e00\u4e25\u82db\u6307\u6807\u4e0a\u5747\u672a\u8fbe\u6807\uff0c\u63d0\u793a\u8be5\u7597\u6548\u5728\u66f4\u6781\u7aef\u7684\u5168\u9762\u6e05\u9664\u65b9\u9762\u4ecd\u6709\u63d0\u5347\u7a7a\u95f4\u3002<\/p>\n<\/li>\n<\/ul>\n<p data-path-to-node=\"6\">\u7efc\u5408\u7f6e\u4fe1\u533a\u95f4\u5206\u6790\uff08\u4e0a\u9650\u4f4e\u4e8e0\uff09\uff0c\u8fd9\u4e9b\u6570\u636e\u4e00\u81f4\u6307\u5411\u6cbb\u7597\u7ec4\u7684\u4e34\u5e8a\u83b7\u76ca\u663e\u8457\u4f18\u4e8e\u5b89\u6170\u5242\uff0c\u80fd\u591f\u6709\u6548\u7f13\u89e3\u7279\u5e94\u6027\u76ae\u708e\u7684\u591a\u79cd\u75c7\u72b6\u6307\u6807\u3002<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%E7%94%9F%E7%89%A9%E6%A0%87%E5%BF%97%E7%89%A9%E5%88%86%E6%9E%90\"><\/span>\u751f\u7269\u6807\u5fd7\u7269\u5206\u6790<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>\u57fa\u7ebf\u65f6\u4e24\u7ec4\u6240\u6709\u68c0\u6d4b\u7ec6\u80de\u56e0\u5b50\u6c34\u5e73\u5747\u65e0\u663e\u8457\u5dee\u5f02\u3002\u6cbb\u7597\u8fc7\u7a0b\u4e2d\uff0cIL-4\u3001IL-5\u3001IL-13\u3001IL-31\u7b49Th2\u76f8\u5173\u7ec6\u80de\u56e0\u5b50\u5728\u7ec4\u95f4\u672a\u89c1\u663e\u8457\u53d8\u5316\u3002\u7136\u800c\u81f3\u7b2c16\u5468\uff0c\u6cbb\u7597\u7ec4\u8840\u6e05TARC\uff08\u5373CCL17\uff09\u6c34\u5e73\u8f83\u5b89\u6170\u5242\u7ec4\u663e\u8457\u964d\u4f4e\uff08\u56fe3a\u2013e\uff09\uff0c\u63d0\u793aAtMSC\u6cbb\u7597\u53ef\u80fd\u901a\u8fc7\u6291\u5236Th2\u7ec6\u80de\u8d8b\u5316\u9014\u5f84\u53d1\u6325\u4f5c\u7528\u3002\u5176\u4ed6\u6807\u5fd7\u7269\u5982PGE2\u3001ECP\u3001TGF-\u03b21\u3001IL-6\u3001IL-8\u7b49\u5728\u5404\u65f6\u95f4\u70b9\u5747\u65e0\u7ec4\u95f4\u663e\u8457\u5dee\u5f02\uff08\u88682\u548c\u8865\u5145\u88685\uff09\u3002<\/p>\n<section>\n<div id=\"attachment_21109\" style=\"width: 1900px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-21109\" class=\"wp-image-21109 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/\u5fae\u4fe1\u56fe\u7247_2025-12-24_113738_612.png\" alt=\"\" width=\"1890\" height=\"1049\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/\u5fae\u4fe1\u56fe\u7247_2025-12-24_113738_612.png 1890w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/\u5fae\u4fe1\u56fe\u7247_2025-12-24_113738_612-300x167.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/\u5fae\u4fe1\u56fe\u7247_2025-12-24_113738_612-1024x568.png 1024w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/\u5fae\u4fe1\u56fe\u7247_2025-12-24_113738_612-768x426.png 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/\u5fae\u4fe1\u56fe\u7247_2025-12-24_113738_612-1536x853.png 1536w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/\u5fae\u4fe1\u56fe\u7247_2025-12-24_113738_612-18x10.png 18w\" sizes=\"(max-width: 1890px) 100vw, 1890px\" \/><p id=\"caption-attachment-21109\" class=\"wp-caption-text\">\u56fe3\uff1a\u5404\u65f6\u95f4\u70b9\u8840\u6db2\u4e2d\u5404\u56e0\u5b50\u6c34\u5e73\u8f83\u57fa\u7ebf\u7684\u5e73\u5747\u53d8\u5316<\/p><\/div>\n<\/section>\n<h3><span class=\"ez-toc-section\" id=\"%E5%AE%89%E5%85%A8%E6%80%A7%E8%AF%84%E4%BC%B0\"><\/span>\u5b89\u5168\u6027\u8bc4\u4f30<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u5728\u5b89\u5168\u6027\u65b9\u9762\uff0c\u6cbb\u7597\u671f\u95f4\u517129\u4f8b\uff0825.4%\uff09\u60a3\u8005\u62a5\u544a43\u4f8b\u6b21\u4e0d\u826f\u4e8b\u4ef6\uff0c\u5176\u4e2d\u836f\u7269\u76f8\u5173\u4e0d\u826f\u53cd\u5e94\uff08ADR\uff09\u53d1\u751f\u7387\u4e3a4.4%\uff085\u4f8b\/10\u4f8b\u6b21\uff09\uff0c\u7ec4\u95f4\u65e0\u663e\u8457\u5dee\u5f02\u3002\u6700\u5e38\u89c1ADR\u4e3a\u5934\u75db\uff082.6%\uff09\uff0c\u5176\u4f59\u5305\u62ec\u5934\u6655\u3001\u8368\u9ebb\u75b9\u3001\u767d\u765c\u98ce\u3001\u6076\u5fc3\u3001\u9759\u8109\u708e\u7b49\uff0c\u53d1\u751f\u7387\u5747\u4f4e\u4e8e1%\u3002\u4ec51\u4f8b\u60a3\u8005\u56e0\u975eADR\u4e0d\u826f\u4e8b\u4ef6\u9000\u51fa\u7814\u7a76\uff0c\u672a\u53d1\u751f\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\uff08SAE\uff09\u3002\u751f\u547d\u4f53\u5f81\u3001\u5b9e\u9a8c\u5ba4\u68c0\u67e5\u53ca\u4f53\u683c\u68c0\u67e5\u5747\u672a\u89c1\u5177\u6709\u4e34\u5e8a\u610f\u4e49\u7684\u5f02\u5e38\u3002<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%E8%AE%A8%E8%AE%BA%E7%A0%94%E7%A9%B6%E7%9A%84%E6%84%8F%E4%B9%89\"><\/span><strong>\u8ba8\u8bba\u7814\u7a76\u7684\u610f\u4e49<\/strong><span 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[]\">\u4e3b\u8981\u53c2\u8003\u8d44\u6599\uff1a<\/p>\n<p data-pm-slice=\"0 0 []\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">[1] <\/span><\/span><span data-pm-slice=\"0 0 []\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">Seok, J., Kim, SY., Lee, WG\u00a0<\/span><\/span><\/span><i><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7b49\u3002<\/span><\/span><\/i><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u00a0\u81ea\u4f53\u8102\u80aa\u5e72\u7ec6\u80de\u6cbb\u7597\u4e2d\u91cd\u5ea6\u7279\u5e94\u6027\u76ae\u708e\u60a3\u8005\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\uff1a\u4e00\u9879\u591a\u4e2d\u5fc3\u3001\u968f\u673a\u3001\u5355\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u7684 II \u671f\u8bd5\u9a8c\u3002\u00a0<\/span><\/span><i><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5e72\u7ec6\u80de\u7814\u7a76\u4e0e\u6cbb\u7597<\/span><\/span><\/i>\u00a0<b><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">16<\/span><\/span><\/b><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> , 671 (2025)\u3002https:\/\/doi.org\/10.1186\/s13287-025-04763-y<\/span><\/span><\/p>\n<p data-pm-slice=\"0 0 []\">\u514d\u8d23\u8bf4\u660e\uff1a\u672c\u6587\u4ec5\u7528\u4e8e\u4f20\u64ad\u79d1\u666e\u77e5\u8bc6\uff0c\u5206\u4eab\u884c\u4e1a\u89c2\u70b9\uff0c\u4e0d\u6784\u6210\u4efb\u4f55\u4e34\u5e8a\u8bca\u65ad\u5efa\u8bae\uff01\u676d\u5409\u5e72\u7ec6\u80de\u6240\u53d1\u5e03\u7684\u4fe1\u606f\u4e0d\u80fd\u66ff\u4ee3\u533b\u751f\u6216\u836f\u5242\u5e08\u7684\u4e13\u4e1a\u5efa\u8bae\u3002\u5982\u6709\u7248\u6743\u7b49\u7591\u95ee\uff0c\u8bf7\u968f\u65f6\u8054\u7cfb\u6211\u3002<\/p>\n<\/blockquote>\n<\/section>","protected":false},"excerpt":{"rendered":"<p>\u7279\u5e94\u6027\u76ae\u708e\uff08AD\uff09\u662f\u4e00\u79cd\u6162\u6027\u708e\u75c7\u6027\u76ae\u80a4\u75c5\uff0c\u4e25\u91cd\u5f71\u54cd\u60a3\u8005\u751f\u6d3b\u8d28\u91cf\uff0c\u800c\u73b0\u6709\u4f20\u7edf\u7597\u6cd5\u4ecd\u5b58\u5728\u4e00\u5b9a\u5c40\u9650\u6027\u3002\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6cbb 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