{"id":21152,"date":"2025-12-26T18:16:00","date_gmt":"2025-12-26T10:16:00","guid":{"rendered":"https:\/\/www.hjtdsm.cn\/?p=21152"},"modified":"2025-12-26T18:19:25","modified_gmt":"2025-12-26T10:19:25","slug":"https-www-hjtdsm-cn-stem-cells-stem-cell-therapy-21152-html","status":"publish","type":"post","link":"https:\/\/www.hjtdsm.cn\/ar\/stem-cells\/stem-cell-therapy\/21152.html","title":{"rendered":"\u771f\u5b9e\u6848\u4f8b\uff01\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6cbb\u75972\u578b\u7cd6\u5c3f\u75c51\u4f8b\uff1a\u5b9e\u73b0\u8840\u7cd6\u8fbe\u6807\u3001\u836f\u7269\u51cf\u91cf\u4e0e\u80f0\u5c9b\u529f\u80fd\u6539\u5584\u7684\u4e09\u91cd\u83b7\u76ca\uff01"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_79_2 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" 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https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-26_170932_972-300x163.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-26_170932_972-768x418.png 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-26_170932_972-18x10.png 18w\" sizes=\"(max-width: 897px) 100vw, 897px\" \/><\/div>\n<div><\/div>\n<div class=\"auto-hide-last-sibling-br paragraph-pP9ZLC paragraph-element br-paragraph-space\">\u7ed3\u679c\u8868\u660e\uff1a 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id=\"%E4%B8%80%E3%80%81%E4%BC%A0%E7%BB%9F%E6%B2%BB%E7%96%97%E7%9A%84%E5%B1%80%E9%99%90%E4%B8%8E%E4%BA%BA%E8%84%90%E5%B8%A6%E9%97%B4%E5%85%85%E8%B4%A8%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E6%96%B0%E7%AD%96%E7%95%A5\"><\/span><strong>\u4e00\u3001\u4f20\u7edf\u6cbb\u7597\u7684\u5c40\u9650\u4e0e\u4eba\u8110\u5e26\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6cbb\u7597\u65b0\u7b56\u7565<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p class=\"auto-hide-last-sibling-br paragraph-pP9ZLC paragraph-element br-paragraph-space\">\u636e\u6d41\u884c\u75c5\u5b66\u7edf\u8ba1\u62a5\u544a\uff0c\u76ee\u524d\u5168\u4e16\u754c20\u81f379\u5c81\u60a3<a href=\"https:\/\/www.hjtdsm.cn\/ar\/stem-cells\/20228.html\/\" target=\"_blank\" rel=\"noopener\">\u062f\u0627\u0621 \u0627\u0644\u0633\u0643\u0631\u064a<\/a>\u7684\u4eba\u6570\u8fbe\u5230\u4e864.15\u4ebf\uff0c\u60a3\u75c5\u7387\u4e3a8.8%\uff0c\u5982\u6b64\u4e00\u6765\uff0c\u81f32030\u5e74\u7cd6\u5c3f\u75c5\u75c5\u4eba\u6570\u91cf\u5c06\u8d85\u8fc73.6\u4ebf\u3002\u5728\u75be\u75c5\u7684\u8fdb\u5c55\u8fc7\u7a0b\u4e2d\uff0c\u673a\u4f53\u901a\u8fc7\u589e\u52a0\u80f0\u5c9b\u7d20\u7684\u5206\u6ccc\u91cf\u6765\u5e94\u5bf9\u80f0\u5c9b\u7d20\u62b5\u6297\uff0c\u7136\u800c\uff0c\u968f\u7740\u65f6\u95f4\u63a8\u79fb\uff0c\u4eba\u4eec\u7684\u80f0\u5c9b\u529f\u80fd\u9010\u6e10\u51cf\u5f31\uff0c\u6700\u7ec8\u5bfc\u81f42\u578b\u7cd6\u5c3f\u75c5\u7684\u51fa\u73b0\u3002<\/p>\n<div class=\"auto-hide-last-sibling-br paragraph-pP9ZLC paragraph-element br-paragraph-space\">\u56e0\u6b64\uff0c\u80f0\u5c9b\u7d20\u62b5\u6297\u5df2\u6210\u4e3aT2DM\u8fdb\u5c55\u6700\u91cd\u8981\u7684\u9884\u6d4b\u6307\u6807\u4e4b\u4e00\uff0c\u662f\u6f5c\u5728\u7684\u6cbb\u7597\u9776\u70b9\u3002\u6839\u636e\u7cd6\u5c3f\u75c5\u7684\u6cbb\u7597\u6307\u5357\uff0c2\u578b\u7cd6\u5c3f\u75c5\u7684\u5e38\u89c4\u6cbb\u7597\u5e94\u57fa\u4e8e\u751f\u6d3b\u65b9\u5f0f\u5e72\u9884\uff0c\u5305\u62ec\u5065\u5eb7\u996e\u98df\u3001\u51cf\u80a5\u548c\u5b9a\u671f\u4f53\u80b2\u953b\u70bc\u3002\u5c3d\u7ba1\u5982\u6b64\uff0c\u8fd9\u4e9b\u5e38\u89c4\u6cbb\u7597\u5e94\u8be5\u4e0e\u964d\u7cd6\u836f\u7269\u4e00\u8d77\u8fdb\u884c\uff0c\u4ee5\u5de9\u56fa\u7ef4\u6301\u6b63\u5e38\u8840\u7cd6\u3002\u4e16\u754c\u4e0a\u5df2\u7ecf\u6709\u4e868\u7c7b\u964d\u7cd6\u836f\u83b7\u6279\uff0c\u5305\u62ec\u4e00\u7ebf\u836f\u7269\u4e8c\u7532\u53cc\u80cd\u548c\u65b0\u5f00\u53d1\u7684\u80f0\u9ad8\u8840\u7cd6\u7d20\u6837\u80bd-1\u53d7\u4f53\u6fc0\u52a8\u5242\uff0c\u4ee5\u53ca\u591a\u79cd\u836f\u7269\u6cbb\u7597\u65b9\u6848\uff0c\u5982\u5355\u836f\u6cbb\u7597\u3001\u53cc\u836f\u6cbb\u7597\u548c\u591a\u836f\u6cbb\u7597\u63d0\u9ad8T2DM\u6cbb\u7597\u7597\u6548\u3002<\/div>\n<div><\/div>\n<div class=\"auto-hide-last-sibling-br paragraph-pP9ZLC paragraph-element br-paragraph-space\">\u7136\u800c\uff0cT2DM\u7684\u67d0\u4e9b\u75c5\u7406\uff0c\u5982\u03b2 \u7ec6\u80de\u8017\u7aed\u3001\u809d\u529f\u80fd\u969c\u788d\u3001\u80f0\u5c9b\u7d20\u62b5\u6297\u548c\u5168\u8eab\u708e\u75c7\uff0c\u4ecd\u7136\u96be\u4ee5\u901a\u8fc7\u4f20\u7edf\u836f\u7269\u6cbb\u7597\u6062\u590d\u3002\u6b64\u5916\uff0c\u8fd9\u4e9b\u836f\u7269\u8fd8\u4f34\u6709\u5927\u91cf\u7684\u98ce\u9669\u548c\u526f\u4f5c\u7528\uff0c\u5305\u62ec\u4f4e\u8840\u7cd6\u3001\u8179\u6cfb\u548c\u809d\u635f\u5bb3\uff0c\u8fd9\u8868\u660e\u5f00\u53d1\u4e00\u79cd\u7406\u60f3\u7684\u6cbb\u7597\u7cd6\u5c3f\u75c5\u836f\u7269\u4ee5\u589e\u5f3a\u80f0\u5c9b\u7d20\u654f\u611f\u6027\u548c\u9006\u8f6c\u80f0\u817a\u03b2\u7ec6\u80de\u8870\u7aed\u662f\u5fc5\u4e0d\u53ef\u5c11\u7684\u3002<\/div>\n<div><\/div>\n<div><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-21158 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/istockphoto-2217097190-612x612-1.jpg\" alt=\"\u771f\u5b9e\u6848\u4f8b\uff01\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6cbb\u75972\u578b\u7cd6\u5c3f\u75c51\u4f8b\uff1a\u5b9e\u73b0\u8840\u7cd6\u8fbe\u6807\u3001\u836f\u7269\u51cf\u91cf\u4e0e\u80f0\u5c9b\u529f\u80fd\u6539\u5584\u7684\u4e09\u91cd\u83b7\u76ca\uff01\" width=\"612\" height=\"415\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/istockphoto-2217097190-612x612-1.jpg 612w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/istockphoto-2217097190-612x612-1-300x203.jpg 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/istockphoto-2217097190-612x612-1-18x12.jpg 18w\" sizes=\"(max-width: 612px) 100vw, 612px\" \/><\/div>\n<div><\/div>\n<div class=\"auto-hide-last-sibling-br paragraph-pP9ZLC paragraph-element br-paragraph-space\">\u6700\u8fd1\uff0c\u7ec6\u80de\u7597\u6cd5\u5df2\u6210\u4e3a\u89e3\u51b3 T2DM \u590d\u6742\u751f\u7406\u75c5\u7406\u7684\u65b0\u4e00\u4ee3\u836f\u7269\u3002\u4ece\u4eba\u8110\u5e26\u63d0\u53d6\u7684\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u5728\u52a8\u7269\u7814\u7a76\u548c\u4e34\u5e8a\u7814\u7a76\u4e2d\u90fd\u663e\u793a\u4e86\u5176\u6cbb\u7597\u4f5c\u7528\uff0c\u56e0\u6b64\u4e3a\u6cbb\u75972\u578b\u7cd6\u5c3f\u75c5\u63d0\u4f9b\u4e86\u4e00\u79cd\u6210\u719f\u7684\u6a21\u5f0f\u3002MSCs \u80fd\u591f\u81ea\u6211\u66f4\u65b0\u5e76\u5728\u4f53\u5916\u5206\u5316\u4e3a\u591a\u79cd\u95f4\u5145\u8d28\u8c31\u7cfb\u3002\u6b64\u5916\uff0c\u7531\u4e8e\u4e3b\u8981\u7ec4\u7ec7\u76f8\u5bb9\u6027\u590d\u5408\u4f53 (MHC)\u2160 \u7c7b\u7684\u4e2d\u95f4\u8868\u8fbe\uff0c\u4ee5\u53caMHC \u2161\u7c7b\u5728\u5176\u7ec6\u80de\u8868\u5c42\u7684\u7f3a\u5931\uff0c\u5b83\u4eec\u8868\u73b0\u51fa\u4f4e\u514d\u75ab\u539f\u6027\u3002\u6b64\u5916\uff0cMSCs\u5206\u6ccc\u7684\u8fc7\u591a\u7684\u7ec6\u80de\u56e0\u5b50\u3001\u751f\u957f\u56e0\u5b50\u548c\u5916\u6ccc\u4f53\u5728\u80f0\u5c9b\u7d20\u654f\u611f\u6027\u548c\u03b2\u7ec6\u80de\u529f\u80fd\u969c\u788d\u7684\u8c03\u8282\u4e2d\u8d77\u7740\u5173\u952e\u4f5c\u7528\u3002<\/div>\n<div><\/div>\n<div class=\"auto-hide-last-sibling-br paragraph-pP9ZLC paragraph-element br-paragraph-space\">\u4eba\u8110\u5e26\u95f4\u5145\u8d28\u5e72\u7ec6\u80de (HUC-MSCs) \u56e0\u5176\u72ec\u7279\u7684\u751f\u7269\u5b66\u7279\u6027\u800c\u6210\u4e3a\u7cd6\u5c3f\u75c5\u53ca\u5176\u5e76\u53d1\u75c7\u6cbb\u7597\u7684\u65b0\u5174\u7b56\u7565\u3002\u8fd9\u4e9b\u7ec6\u80de\u6765\u6e90\u4e30\u5bcc\uff0c\u5177\u6709\u9ad8\u589e\u6b96\u6f5c\u80fd\u548c\u5f3a\u5927\u7684\u7ec6\u80de\u6d3b\u529b\uff0c\u4e14\u4f4e\u514d\u75ab\u539f\u6027\uff0c\u4f7f\u5176\u5728\u4e34\u5e8a\u5e94\u7528\u4e2d\u5c55\u73b0\u51fa\u663e\u8457\u4f18\u52bf\u3002HUC-MSCs\u7684\u53d6\u6750\u4e0d\u4ec5\u4fbf\u6377\uff0c\u4e14\u4f34\u968f\u7684\u6c61\u67d3\u98ce\u9669\u8f83\u5c0f\uff0c\u56e0\u800c\u5728\u533b\u7597\u5e9f\u5f03\u7269\u8f6c\u5316\u5229\u7528\u4e2d\u4e5f\u663e\u793a\u4e86\u6f5c\u5728\u7684\u4ef7\u503c\uff0c\u5e76\u907f\u514d\u4e86\u4f26\u7406\u6cd5\u5f8b\u4e89\u8bae\u3002<\/div>\n<h2><span class=\"ez-toc-section\" id=\"%E4%BA%8C%E3%80%81%E8%84%90%E5%B8%A6%E9%97%B4%E5%85%85%E8%B4%A8%E5%B9%B2%E7%BB%86%E8%83%9E%E7%A7%BB%E6%A4%8D%E6%B2%BB%E7%96%972%E5%9E%8B%E7%B3%96%E5%B0%BF%E7%97%85%E7%9A%84%E4%BD%9C%E7%94%A8%E6%9C%BA%E5%88%B6\"><\/span>\u4e8c\u3001\u8110\u5e26\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u79fb\u690d\u6cbb\u75972\u578b\u7cd6\u5c3f\u75c5\u7684\u4f5c\u7528\u673a\u5236<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<div class=\"auto-hide-last-sibling-br paragraph-pP9ZLC paragraph-element br-paragraph-space\">\u636e\u6709\u5173\u6587\u732e\u62a5\u9053\uff0c\u8110\u5e26\u95f4\u5145\u8d28\u5e72\u7ec6\u80de (HUC-MSCs) \u4f5c\u4e3a\u7cd6\u5c3f\u75c5\u6cbb\u7597\u7684\u65b0\u7b56\u7565\uff0c\u5176\u4f5c\u7528\u673a\u5236\u53ef\u80fd\u5305\u62ec\u4ee5\u4e0b\u51e0\u4e2a\u65b9\u9762\uff1a<\/div>\n<ul>\n<li class=\"auto-hide-last-sibling-br paragraph-pP9ZLC paragraph-element br-paragraph-space\">(1) \u5b9a\u5411\u8fc1\u79fb\uff1aHUC-MSCs \u80fd\u5b9a\u5411\u8fc1\u79fb\u81f3\u53d7\u635f\u7684\u80f0\u817a\u7ec4\u7ec7\uff0c\u901a\u8fc7\u5c40\u90e8\u8425\u517b\u652f\u6301\u548c\u65c1\u5206\u6ccc\u56e0\u5b50\u7684\u5206\u6ccc\u53d1\u6325\u4f5c\u7528\u3002<\/li>\n<li class=\"auto-hide-last-sibling-br paragraph-pP9ZLC paragraph-element br-paragraph-space\">(2) \u5206\u5316\u4e3a\u80f0\u5c9b\u7d20\u751f\u6210\u7ec6\u80de\uff1aHUC-MSCs\u53ef\u4ee5\u5206\u5316\u4e3a\u80f0\u5c9b\u7d20\u751f\u6210\u7ec6\u80de (IPCs)\uff0c\u4ece\u800c\u76f4\u63a5\u4fc3\u8fdb\u80f0\u5c9b\u7d20\u7684\u4ea7\u751f\u3002<\/li>\n<li class=\"auto-hide-last-sibling-br paragraph-pP9ZLC paragraph-element br-paragraph-space\">(3) \u9006\u8f6c \u03b2 \u7ec6\u80de\u53bb\u5206\u5316\u8fdb\u7a0b\uff1aHUC-MSCs\u6709\u52a9\u4e8e\u9006\u8f6c\u03b2\u7ec6\u80de\u7684\u53bb\u5206\u5316\u8fdb\u7a0b\uff0c\u6539\u5584\u03b2\u7ec6\u80de\u529f\u80fd\u969c\u788d\uff0c\u5e76\u4fc3\u8fdb\u80f0\u817a\u03b2\u7ec6\u80de\u7684\u518d\u751f\u3002<\/li>\n<li class=\"auto-hide-last-sibling-br paragraph-pP9ZLC paragraph-element br-paragraph-space\">(4) \u6297\u708e\u4f5c\u7528\uff1aHUC-MSCs \u80fd\u591f\u5206\u6ccc\u6297\u708e\u7ec6\u80de\u56e0\u5b50\uff0c\u8c03\u63a7\u5de8\u566c\u7ec6\u80de\u8868\u578b\uff0c\u51cf\u8f7b\u80f0\u817a\u7684\u708e\u75c7\u53cd\u5e94\u3002<\/li>\n<li class=\"auto-hide-last-sibling-br paragraph-pP9ZLC paragraph-element br-paragraph-space\">(5) \u63d0\u9ad8\u80f0\u5c9b\u7d20\u654f\u611f\u6027\uff1aHUC-MSCs\u8fd8\u53ef\u4ee5\u589e\u5f3a\u9776\u7ec4\u7ec7\u7684\u80f0\u5c9b\u7d20\u654f\u611f\u6027\uff0c\u4ece\u800c\u6539\u5584\u80f0\u5c9b\u7d20\u62b5\u6297\u3002<\/li>\n<\/ul>\n<div class=\"auto-hide-last-sibling-br paragraph-pP9ZLC paragraph-element br-paragraph-space\">\u76ee\u524d\u5168\u4e16\u754c\u5df2\u7ecf\u5f00\u5c55\u591a\u9879\u8110\u5e26\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6cbb\u75972\u578b\u7cd6\u5c3f\u75c5\u53ca\u5176\u5e76\u53d1\u75c7\u7684\u4e34\u5e8a\u7814\u7a76\u3002\u5176\u4e2dLi Zang\u56e2\u961f\u7684\u8bd5\u9a8c\u4e2d\u8868\u660e\uff1a\u572848\u5468\u7ed3\u675f\u540e\uff0c\u6cbb\u7597\u7ec4\u4e3b\u8981\u7ec8\u70b9\u8fbe\u6210\u7387 (20%) \u663e\u8457\u9ad8\u4e8e\u5bf9\u7167\u7ec4 (4.55%)\uff0c\u8fd9\u4e3aT2DM\u7684\u6cbb\u7597\u63d0\u4f9b\u4e86\u4e00\u79cd\u65b0\u7684\u6cbb\u7597\u65b9\u5f0f\u3002\u672c\u7814\u7a76\u62a5\u90531\u4f8b\u4eba\u8110\u5e26\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6cbb\u7597\u76842\u578b\u7cd6\u5c3f\u75c5\u6848\u4f8b\uff0c<a href=\"https:\/\/www.hjtdsm.cn\/ar\/stem-cells\/stem-cell-therapy\/19950.html\/\" target=\"_blank\" rel=\"noopener\">\u610f\u5728\u8bc4\u4f30\u8be5\u7597\u6cd5\u5bf92\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u7684\u6709\u6548\u6027\u4e0e\u5b89\u5168\u6027<\/a>\uff0c\u4e3a\u5176\u4e34\u5e8a\u5e94\u7528\u8f6c\u5316\u63d0\u4f9b\u5b9e\u8df5\u4f9d\u636e\u3002<\/div>\n<div>\n<h2 class=\"header-iWP5WJ auto-hide-last-sibling-br\"><span class=\"ez-toc-section\" id=\"%E4%B8%89%E3%80%81%E8%B5%84%E6%96%99%E4%B8%8E%E6%96%B9%E6%B3%95\"><\/span>\u4e09\u3001\u8d44\u6599\u4e0e\u65b9\u6cd5<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<\/div>\n<div>\n<h3 class=\"ds-markdown-paragraph\"><span class=\"ez-toc-section\" id=\"%E7%A0%94%E7%A9%B6%E8%AE%BE%E8%AE%A1%E4%B8%8E%E4%BC%A6%E7%90%86%E8%A7%84%E8%8C%83\"><\/span><strong>\u7814\u7a76\u8bbe\u8ba1\u4e0e\u4f26\u7406\u89c4\u8303<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p class=\"ds-markdown-paragraph\">\u672c\u7814\u7a76\u4e3a\u4e00\u9879\u9075\u5faa\u300a\u8d6b\u5c14\u8f9b\u57fa\u5ba3\u8a00\u300b\u539f\u5219\u7684\u4e34\u5e8a\u7814\u7a76\uff0c\u5df2\u901a\u8fc7\u533b\u9662\u4f26\u7406\u5ba1\u67e5\u59d4\u5458\u4f1a\u6279\u51c6\uff0c\u5e76\u5728\u4e2d\u56fd\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u5fc3\u5b8c\u6210\u6ce8\u518c\u3002\u6240\u6709\u53c2\u4e0e\u60a3\u8005\u5747\u7b7e\u7f72\u77e5\u60c5\u540c\u610f\u4e66\uff0c\u786e\u4fdd\u7814\u7a76\u7b26\u5408\u4f26\u7406\u4e0e\u6cd5\u5f8b\u89c4\u8303\u3002\u7814\u7a76\u5bf9\u8c61\u4e3a\u4e00\u540d60\u5c81\u7537\u60272\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\uff0c\u75c5\u7a0b\u8fbe20\u5e74\uff0c\u4f34\u6709\u9ad8\u8840\u538b\u3001\u8102\u80aa\u809d\u53ca\u7cd6\u5c3f\u75c5\u89c6\u7f51\u819c\u75c5\u53d81\u671f\uff0c\u4e14\u65e2\u5f80\u80f0\u5c9b\u7d20\u8054\u5408\u53e3\u670d\u836f\u6cbb\u7597\u4e0b\u8840\u7cd6\u63a7\u5236\u4e0d\u4f73\uff08HbA1c 8.5%\uff09\uff0c\u4e8e2022\u5e746\u6708\u5728\u5317\u4eac\u5927\u5b66\u6df1\u5733\u533b\u9662\u5185\u5206\u6ccc\u79d1\u63a5\u53d7\u4eba\u8110\u5e26\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08hUC-MSCs\uff09\u6cbb\u7597\u3002<\/p>\n<h3 class=\"ds-markdown-paragraph\"><span class=\"ez-toc-section\" id=\"%E5%B9%B2%E7%BB%86%E8%83%9E%E5%88%B6%E5%A4%87%E4%B8%8E%E8%B4%A8%E9%87%8F%E6%8E%A7%E5%88%B6\"><\/span><strong>\u5e72\u7ec6\u80de\u5236\u5907\u4e0e\u8d28\u91cf\u63a7\u5236<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p class=\"ds-markdown-paragraph\">\u6240\u4f7f\u7528\u7684hUC-MSCs\u6ce8\u5c04\u6db2\u7531\u5317\u79d1\u751f\u7269\u79d1\u6280\u516c\u53f8\uff08\u6df1\u5733\uff09\u63d0\u4f9b\u3002\u7ec6\u80de\u6765\u6e90\u4e8e\u8db3\u6708\u80ce\u513f\u8110\u5e26\uff0c\u901a\u8fc7\u7ec4\u7ec7\u5757\u8d34\u58c1\u6cd5\u5206\u79bb\u57f9\u517b\uff0c\u83b7\u53d6\u7b2c2\u20114\u4ee3\u7ec6\u80de\u3002\u5236\u5907\u8fc7\u7a0b\u5305\u542b\u7cfb\u7edf\u6027\u8d28\u91cf\u68c0\u6d4b\uff1aHLA\u5206\u578b\u3001\u8868\u9762\u6807\u5fd7\u7269\u9274\u5b9a\u3001\u4e09\u7cfb\u5206\u5316\u80fd\u529b\u9a8c\u8bc1\u3001\u7aef\u7c92\u9176\u6d3b\u6027\u3001\u7532\u57fa\u5316\u72b6\u6001\u3001\u6838\u578b\u5206\u6790\u3001\u764c\u57fa\u56e0\/\u6291\u764c\u57fa\u56e0\u68c0\u6d4b\u53ca\u75c5\u539f\u5b66\u7b5b\u67e5\u3002\u5408\u683c\u7ec6\u80de\u7ecf\u7a0b\u5e8f\u964d\u6e29\u540e\u51bb\u5b58\u4e8e\u2011196\u00b0C\u6db2\u6c2e\uff0c\u4e34\u5e8a\u4f7f\u7528\u524d\u7ecf\u590d\u82cf\u3001\u6d17\u6da4\u3001\u8d28\u68c0\u53ca\u91cd\u60ac\uff0c\u5168\u7a0b\u572812\u5c0f\u65f6\u5185\u5b8c\u6210\uff0c\u7b26\u5408\u56fd\u9645\u7ec6\u80de\u6cbb\u7597\u5b66\u4f1a\uff08ISCT\uff09\u8d28\u91cf\u6807\u51c6\u3002<\/p>\n<h3 class=\"ds-markdown-paragraph\"><span class=\"ez-toc-section\" id=\"%E6%B2%BB%E7%96%97%E6%96%B9%E6%A1%88%E4%B8%8E%E8%A7%82%E5%AF%9F%E6%B5%81%E7%A8%8B\"><\/span><strong>\u6cbb\u7597\u65b9\u6848\u4e0e\u89c2\u5bdf\u6d41\u7a0b<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p class=\"ds-markdown-paragraph\">\u7814\u7a76\u8bbe\u5b9a\u4e868\u5468\u7684\u836f\u7269\u7a33\u5b9a\u7b5b\u67e5\u671f\uff0c\u57fa\u7ebf\u8bc4\u4f30\u540e\u5bf9\u60a3\u8005\u8fdb\u884chUC-MSCs\u9759\u8109\u8f93\u6ce8\uff0c\u5242\u91cf\u4e3a1\u00d710\u2076cells\/kg\/\u6b21\uff0c\u6bcf\u54681\u6b21\u3001\u8fde\u7eed3\u5468\u3002\u6bcf\u6b21\u8f93\u6ce8\u540e\u4f4f\u9662\u89c2\u5bdf24\u5c0f\u65f6\u3002\u968f\u8bbf\u65f6\u95f4\u70b9\u5305\u62ec\u6cbb\u7597\u7ed3\u675f\u65f6\uff08W0\uff09\u53ca\u8f93\u6ce8\u540e\u7b2c1\u30012\u30013\u30014\u300112\u5468\uff0c\u5141\u8bb8\u00b13\u5929\u7684\u5f39\u6027\u8bbf\u89c6\u7a97\u3002\u7814\u7a76\u671f\u95f4\u60a3\u8005\u7ef4\u6301\u6807\u51c6\u5316\u996e\u98df\u4e0e\u8fd0\u52a8\uff0c\u5e76\u6839\u636e\u6307\u5357\u52a8\u6001\u8c03\u6574\u964d\u7cd6\u65b9\u6848\uff0c\u63a7\u5236\u76ee\u6807\u4e3a\u7a7a\u8179\u8840\u7cd64.4\u20137.0mmol\/L\u3001\u9910\u540e\u8840\u7cd64.4\u201310mmol\/L\uff0c\u9884\u8bbe\u80f0\u5c9b\u7d20\u4e0e\u53e3\u670d\u836f\u7684\u51cf\u505c\u6761\u4ef6\u3002<\/p>\n<h3 class=\"ds-markdown-paragraph\"><span class=\"ez-toc-section\" id=\"%E7%BB%93%E5%B1%80%E8%AF%84%E4%BC%B0%E6%8C%87%E6%A0%87\"><\/span><strong>\u7ed3\u5c40\u8bc4\u4f30\u6307\u6807<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p class=\"ds-markdown-paragraph\">\u6709\u6548\u6027\u8bc4\u4f30\u6db5\u76d6\u8840\u7cd6\u76f8\u5173\u6307\u6807\uff08\u7a7a\u8179\u8840\u7cd6\u3001\u9910\u540e2\u5c0f\u65f6\u8840\u7cd6\u3001\u7cd6\u5316\u8840\u7ea2\u86cb\u767d\uff09\u3001C\u80bd\u6c34\u5e73\uff08\u7a7a\u8179\u53ca\u9910\u540e2\u5c0f\u65f6\uff09\uff0c\u4ee5\u53ca\u901a\u8fc7\u7a33\u6001\u6a21\u578b\u8ba1\u7b97\u7684\u80f0\u5c9b\u7d20\u62b5\u6297\u6307\u6570\uff08HOMA-IR\uff09\u548c\u80f0\u5c9b\u03b2\u7ec6\u80de\u529f\u80fd\u6307\u6570\uff08HOMA-\u03b2\uff09\u3002\u5b89\u5168\u6027\u8bc4\u4f30\u7cfb\u7edf\u8bb0\u5f55\u6240\u6709\u4e0d\u826f\u4e8b\u4ef6\uff0c\u5305\u62ec\u8f93\u6ce8\u76f8\u5173\u53cd\u5e94\uff08\u751f\u547d\u4f53\u5f81\u5f02\u5e38\u3001\u8fc7\u654f\u3001\u53d1\u70ed\u7b49\uff09\u3001\u5b9e\u9a8c\u5ba4\u6307\u6807\u5f02\u5e38\uff08\u809d\u80be\u529f\u80fd\u3001\u51dd\u8840\u3001\u8840\u5e38\u89c4\u7b49\uff09\u3001\u5f71\u50cf\u5b66\u68c0\u67e5\u7ed3\u679c\uff0c\u5e76\u7279\u522b\u76d1\u6d4b\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\uff08\u5982\u4e25\u91cd\u4f4e\u8840\u7cd6\u3001\u65b0\u53d1\u611f\u67d3\u3001\u6076\u6027\u80bf\u7624\u6216\u6b7b\u4ea1\uff09\u3002<\/p>\n<h2 class=\"header-iWP5WJ auto-hide-last-sibling-br\"><span class=\"ez-toc-section\" id=\"%E5%9B%9B%E3%80%81%E7%BB%93%E6%9E%9C\"><\/span>\u56db\u3001\u7ed3\u679c<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<h3 class=\"header-iWP5WJ auto-hide-last-sibling-br\"><span class=\"ez-toc-section\" id=\"%E6%9C%89%E6%95%88%E6%80%A7\"><\/span>\u6709\u6548\u6027<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p class=\"header-iWP5WJ auto-hide-last-sibling-br\"><strong>\u8840\u7cd6\u63a7\u5236\u60c5\u51b5\uff1a<\/strong>\u5728\u968f\u8bbf\u8fc7\u7a0b\u4e2d\uff0c<strong>\u60a3\u8005\u7b2c4\u300112\u5468\u7cd6\u5316\u8840\u7ea2\u86cb\u767d\u5747\u63a7\u5236\u8fbe\u6807\uff0c\u5176\u4e2d\u5728\u7b2c12\u5468\uff0c\u7cd6\u5316\u8840\u7ea2\u86cb\u767d\u964d\u81f3\u6700\u4f4e\uff0c\u4e3a5.3%\uff1b\u5728\u968f\u8bbf\u8fc7\u7a0b\u4e2d\uff0c\u60a3\u8005\u7a7a\u8179\u8840\u7cd6 (FBG) \u6301\u7eed\u4e0b\u964d<\/strong>\uff0c\u9910\u540e2\u5c0f\u65f6\u8840\u7cd6 (2-hour postprandial blood glucose, PBG) \u5747\u4f4e\u4e8e\u57fa\u7ebf\u6c34\u5e73 (\u89c1\u56fe 1)\u3002<\/p>\n<div id=\"attachment_21155\" style=\"width: 745px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-21155\" class=\"wp-image-21155 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-26_174317_202.png\" alt=\"\" width=\"735\" height=\"212\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-26_174317_202.png 735w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-26_174317_202-300x87.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-26_174317_202-18x5.png 18w\" sizes=\"(max-width: 735px) 100vw, 735px\" \/><p id=\"caption-attachment-21155\" class=\"wp-caption-text\">\u56fe1\uff1a\u968f\u8bbf\u671f\u95f4\u8840\u7cd6\u63a7\u5236\u60c5\u51b5\u3002\u6ce8\uff1a\u56fe1A\uff1aW0 \u4e0e W4\u3001W12 \u7684 HbA1c \u6c34\u5e73\u7684\u53d8\u5316\uff1b\u56fe1B\uff1aW0 \u4e0e W4\u3001W12 \u7684 FBG \u6c34\u5e73\u7684\u53d8\u5316\uff1b\u56fe1C\uff1aW0 \u4e0e W4\u3001W12 \u7684 PBG \u6c34\u5e73\u7684\u53d8\u5316\u3002<\/p><\/div>\n<p class=\"header-iWP5WJ auto-hide-last-sibling-br\"><strong>\u80f0\u5c9b\u60c5\u51b5\uff1a<\/strong>\u9759\u8109\u8f93\u6ce8\u8110\u5e26\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u540e\uff0c<strong>\u60a3\u8005FCP\u5728\u7b2c4\u5468\u4e0b\u964d\u81f3\u6700\u4f4e\uff0c\u968f\u540e\u4e0a\u5347\uff1b\u800cPCP\u5728\u8f93\u6ce8\u8110\u5e26\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u540e\uff0c\u57284\u5468\u540e\u5f00\u59cb\u4e0a\u5347\u81f312\u5468\uff1b\u5c31HOMA-\u03b2\u800c\u8a00\uff0c\u57284\u5468\u540e\u5f00\u59cb\u4e0a\u5347\uff0c\u4e8e12\u5468\u5230\u8fbe\u9ad8\u503c\uff1b\u800cHOMA-IR\uff0c\u5728\u8f93\u6ce8hUC-MSCs\u540e\u6301\u7eed\u4e0b\u964d\u81f3 12 \u5468\uff0c\u80f0\u5c9b\u529f\u80fd\u6062\u590d\u4e0e\u80f0\u5c9b\u7d20\u62b5\u6297\u51cf\u8f7b\u5747\u4e8e12\u5468\u5230\u8fbe\u6700\u4f73\u6548\u679c<\/strong> (\u89c1\u56fe2)\u3002<\/p>\n<div id=\"attachment_21154\" style=\"width: 520px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-21154\" class=\"wp-image-21154 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-26_174333_251.png\" alt=\"\" width=\"510\" height=\"388\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-26_174333_251.png 510w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-26_174333_251-300x228.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-26_174333_251-16x12.png 16w\" sizes=\"(max-width: 510px) 100vw, 510px\" \/><p id=\"caption-attachment-21154\" class=\"wp-caption-text\">\u56fe2\uff1a\u968f\u8bbf\u671f\u95f4\u80f0\u5c9b\u60c5\u51b5\u3002\u6ce8\uff1a\u56fe2A\uff1aW0\u4e0eW4\u3001W12\u7684FCP\u6c34\u5e73\u7684\u53d8\u5316\uff1b\u56fe2B\uff1aW0 \u4e0e W4\u3001W12 \u7684 PCP\u6c34\u5e73\u7684\u53d8\u5316\uff1b\u56fe2C\uff1aW0 \u4e0e W4\u3001W12 \u7684 HOMA-\u03b2 \u6c34\u5e73\u7684\u53d8\u5316\uff1b\u56fe2D\uff1aW0 \u4e0e W4\u3001W12 \u7684 HOMA-IR \u7684\u53d8\u5316\u3002<\/p><\/div>\n<p class=\"header-iWP5WJ auto-hide-last-sibling-br\"><strong>\u964d\u7cd6\u836f\u7269\u8c03\u6574\uff1a<\/strong>\u60a3\u8005\u5728\u524d\u4e09\u6b21\u8f93\u6ce8\u8110\u5e26\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u540e<strong>\u9010\u6e10\u5b9e\u73b0\u964d\u7cd6\u836f\u7269\u51cf\u91cf\uff0c\u5230\u7b2c4\u5468\u5b9e\u73b0\u4e86\u51cf\u505c\u53e3\u670d\u964d\u7cd6\u836f\u7269\uff0c\u52304\u5468\u80f0\u5c9b\u7d20\u7528\u91cf\u8f83\u57fa\u7ebf\u80f0\u5c9b\u7d20\u7528\u91cf\u4e0b\u964d\u5927\u4e8e50%<\/strong>\u3002\u5177\u4f53\u964d\u7cd6\u65b9\u6848\u8c03\u6574\u89c1\u88681\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-21157 aligncenter\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-26_174205_314.png\" alt=\"\" width=\"422\" height=\"213\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-26_174205_314.png 422w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-26_174205_314-300x151.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-26_174205_314-18x9.png 18w\" sizes=\"(max-width: 422px) 100vw, 422px\" \/><\/p>\n<h3 class=\"header-iWP5WJ auto-hide-last-sibling-br\"><span class=\"ez-toc-section\" id=\"%E5%AE%89%E5%85%A8%E6%80%A7\"><\/span>\u5b89\u5168\u6027<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<div class=\"auto-hide-last-sibling-br paragraph-pP9ZLC paragraph-element br-paragraph-space\">\u8f93\u6ce8\u8fc7\u7a0b\u4e2d\u65e0\u76ae\u80a4\u8fc7\u654f\u53ca\u5176\u4ed6\u5c40\u90e8\u5f02\u5e38\u75c7\u72b6\u6216\u4f53\u5f81\uff0c\u968f\u8bbf12\u5468\u4e2d\u8840\u3001\u5c3f\u3001\u4fbf\u68c0\u67e5\u53ca\u751f\u5316\u68c0\u67e5 (\u5305\u62ec\u51dd\u8840\u529f\u80fd\u3001\u708e\u75c7\u6307\u6807\u3001\u80bf\u7624\u6807\u5fd7\u7269\u3001\u809d\u80be\u529f\u80fd) \u6b63\u5e38 (\u89c1\u88682)\u3002\u9664\u809d\u80c6\u813e\u80f0\u5f69\u8d85\u63d0\u793a\u8f7b\u5ea6\u8102\u80aa\u809d\u58f0\u50cf\u53ca\u773c\u5e95\u68c0\u67e5\u63d0\u793a\u7cd6\u5c3f\u75c5\u89c6\u7f51\u819c\u75c5\u53d81\u671f\u5916\uff0c\u4f59\u5fc3\u7535\u56fe\u3001\u80f8\u7247\u3001\u611f\u89c9\u9608\u503c\u672a\u89c1\u660e\u663e\u5f02\u5e38\uff0c\u672a\u89c1\u80ba\u90e8\u3001\u809d\u80c6\u813e\u80f0\u7b49\u810f\u5668\u51fa\u73b0\u65b0\u53d1\u7ed3\u8282 \/ \u80bf\u7624\u7b49\u60c5\u51b5\uff0c\u968f\u8bbf\u8fc7\u7a0b\u4e2d\u672a\u51fa\u73b0\u611f\u67d3\u3001\u4e25\u91cd\u4f4e\u8840\u7cd6\u53ca\u6025\u6027\u5fc3\u8111\u8840\u7ba1\u7b49\u4e8b\u4ef6\u3002<\/div>\n<\/div>\n<div><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-21156 aligncenter\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-26_174223_170.png\" alt=\"\" width=\"385\" height=\"242\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-26_174223_170.png 385w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-26_174223_170-300x189.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-26_174223_170-18x12.png 18w\" sizes=\"(max-width: 385px) 100vw, 385px\" \/><\/div>\n<h2><span class=\"ez-toc-section\" id=\"%E4%BA%94%E3%80%81%E5%9B%9B%E5%A4%A7%E6%96%B9%E9%9D%A2%E8%AE%A8%E8%AE%BA%E8%84%90%E5%B8%A6%E9%97%B4%E5%85%85%E8%B4%A8%E5%B9%B2%E7%BB%86%E8%83%9E%E7%A7%BB%E6%A4%8D%E6%B2%BB%E7%96%972%E5%9E%8B%E7%B3%96%E5%B0%BF%E7%97%85%E7%9A%84%E6%9C%89%E6%95%88%E6%80%A7\"><\/span>\u4e94\u3001\u56db\u5927\u65b9\u9762\u8ba8\u8bba\u8110\u5e26\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u79fb\u690d\u6cbb\u75972\u578b\u7cd6\u5c3f\u75c5\u7684\u6709\u6548\u6027<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<div>\n<h3 class=\"ds-markdown-paragraph\"><span class=\"ez-toc-section\" id=\"01%E3%80%81%E6%98%BE%E8%91%97%E6%94%B9%E5%96%84%E8%A1%80%E7%B3%96%E6%8E%A7%E5%88%B6%EF%BC%8C%E7%96%97%E6%95%88%E4%B8%8E%E4%BC%A0%E7%BB%9F%E8%8D%AF%E7%89%A9%E7%9B%B8%E5%BD%93\"><\/span><strong>01\u3001\u663e\u8457\u6539\u5584\u8840\u7cd6\u63a7\u5236\uff0c\u7597\u6548\u4e0e\u4f20\u7edf\u836f\u7269\u76f8\u5f53<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<\/div>\n<p>\u7cd6\u5316\u8840\u7ea2\u86cb\u767d (HbA1c) \u4f5c\u4e3a\u8bc4\u4f302~3\u4e2a\u6708\u5e73\u5747\u8840\u7cd6\u6c34\u5e73\u7684\u5173\u952e\u6307\u6807\uff0c\u80fd\u6709\u6548\u53cd\u6620\u957f\u671f\u8840\u7cd6\u63a7\u5236\u72b6\u6001\uff0c\u662f\u672c\u7814\u7a76\u7684\u6838\u5fc3\u7597\u6548\u89c2\u5bdf\u7ec8\u70b9\u3002<\/p>\n<p>Li Zang\u7b49\u5f00\u5c55\u7684 \u2161 \u671f\u968f\u673a\u53cc\u76f2\u5bf9\u7167\u8bd5\u9a8c (n=91) \u8868\u660e\uff1a\u63a5\u53d73\u6b21UC-MSCs\u9759\u8109\u8f93\u6ce8\u7684\u6cbb\u7597\u7ec4 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HbA1c\u53caFBG\u6765\u770b\uff0c<strong>\u60a3\u800512\u5468\u524d\u6301\u7eed\u4e0b\u964d\uff0c\u8003\u8651\u9759\u8109\u8f93\u6ce8hUC-MSCs\u8d77\u5230\u964d\u7cd6\u4f5c\u7528\uff0c\u8bf4\u660e\u9759\u8109\u8f93\u6ce8hUC-MSCs\u524d\u671f\u4f5c\u7528\u660e\u663e<\/strong>\uff0c\u4f46\u76ee\u524d\u5c1a\u672a\u6709\u5927\u578b\u7814\u7a76\u9759\u8109\u6ce8\u5c04hUC-MSCs\u7684\u6700\u4f73\u5242\u91cf\u3001\u6b21\u6570\u53ca\u6700\u4f73\u95f4\u9694\u65f6\u957f\u7b49\uff0c\u672a\u6765\u4ecd\u9700\u8981\u66f4\u591a\u7684\u4e34\u5e8a\u8bd5\u9a8c\u6765\u7814\u7a76hUC-MSCs\u76f8\u5173\u7684\u4e34\u5e8a\u4f7f\u7528\u95ee\u9898\u3002<\/p>\n<div>\n<h3 class=\"ds-markdown-paragraph\"><span class=\"ez-toc-section\" id=\"02%E3%80%81%E5%8F%AF%E8%83%BD%E6%94%B9%E5%96%84%E8%83%B0%E5%B2%9B%CE%B2%E7%BB%86%E8%83%9E%E5%8A%9F%E8%83%BD%EF%BC%8C%E6%95%88%E6%9E%9C%E5%91%88%E7%8E%B0%E5%BB%B6%E8%BF%9F%E6%80%A7\"><\/span><strong>02\u3001\u53ef\u80fd\u6539\u5584\u80f0\u5c9b\u03b2\u7ec6\u80de\u529f\u80fd\uff0c\u6548\u679c\u5448\u73b0\u5ef6\u8fdf\u6027<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p class=\"ds-markdown-paragraph\">\u9664\u4e86\u964d\u7cd6\uff0c<strong>hUC-MSCs\u6cbb\u7597\u8fd8\u53ef\u80fd\u901a\u8fc7\u591a\u79cd\u673a\u5236\u6539\u5584\u80f0\u5c9b\u03b2\u7ec6\u80de\u529f\u80fd<\/strong>\u3002\u52a8\u7269\u5b9e\u9a8c\u8868\u660e\uff0c\u5176\u53ef\u4fc3\u8fdb\u03b2\u7ec6\u80de\u589e\u6b96\u3001\u6539\u5584\u81ea\u566c\u3001\u8c03\u8282\u5c40\u90e8\u514d\u75ab\u5fae\u73af\u5883\u3002\u5728\u672c\u6848\u4f8b\u4e2d\uff0c\u8fd9\u4e00\u6539\u5584\u4f5c\u7528\u5e76\u975e\u7acb\u7aff\u89c1\u5f71\uff0c\u60a3\u8005\u53cd\u6620\u03b2\u7ec6\u80de\u529f\u80fd\u7684\u7a7a\u8179C\u80bd\u548c\u9910\u540eC\u80bd\u6c34\u5e73\u5728\u6cbb\u75974\u5468\u540e\u624d\u5f00\u59cb\u6301\u7eed\u4e0a\u5347\u81f312\u5468\uff0c\u63d0\u793ahUC-MSCs\u5bf9\u80f0\u5c9b\u529f\u80fd\u7684\u4fee\u590d\u4f5c\u7528\u53ef\u80fd\u662f\u4e00\u4e2a\u76f8\u5bf9\u7f13\u6162\u7684\u8fc7\u7a0b\u3002<\/p>\n<h3 class=\"ds-markdown-paragraph\"><span class=\"ez-toc-section\" id=\"03%E3%80%81%E9%80%9A%E8%BF%87%E5%A4%9A%E9%9D%B6%E7%82%B9%E6%9C%BA%E5%88%B6%E6%9C%89%E6%95%88%E6%94%B9%E5%96%84%E8%83%B0%E5%B2%9B%E7%B4%A0%E6%8A%B5%E6%8A%97\"><\/span><strong>03\u3001\u901a\u8fc7\u591a\u9776\u70b9\u673a\u5236\u6709\u6548\u6539\u5584\u80f0\u5c9b\u7d20\u62b5\u6297<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p class=\"ds-markdown-paragraph\">\u80f0\u5c9b\u7d20\u62b5\u6297\u662f2\u578b\u7cd6\u5c3f\u75c5\u7684\u6838\u5fc3\u75c5\u7406\u73af\u8282\uff0c\u800chUC-MSCs\u88ab\u8bc1\u5b9e\u80fd\u591a\u9014\u5f84\u6539\u5584\u8fd9\u4e00\u72b6\u6001\u3002\u5176\u673a\u5236\u5305\u62ec\u6fc0\u6d3b\u5173\u952e\u7684\u80f0\u5c9b\u7d20\u4fe1\u53f7\u901a\u8def\uff08\u5982IRS1\/Akt\uff09\u3001\u6291\u5236NLRP3\u708e\u75c7\u5c0f\u4f53\u4ecb\u5bfc\u7684\u6162\u6027\u708e\u75c7\uff0c\u4ee5\u53ca\u8c03\u63a7\u809d\u810f\u7cd6\u5f02\u751f\u5173\u952e\u9176\u7684\u8868\u8fbe\u3002<strong>\u672c\u6848\u4f8b\u4e2d\u60a3\u8005\u7684\u80f0\u5c9b\u7d20\u62b5\u6297\u6307\u6570\u5728\u968f\u8bbf\u671f\u95f4\u6301\u7eed\u4f4e\u4e8e\u57fa\u7ebf\uff0c\u5e76\u572812\u5468\u65f6\u964d\u81f3\u6700\u4f4e\uff0c\u4e3ahUC-MSCs\u6539\u5584\u4eba\u4f53\u80f0\u5c9b\u7d20\u62b5\u6297\u63d0\u4f9b\u4e86\u76f4\u63a5\u7684\u4e34\u5e8a\u8bc1\u636e<\/strong>\u3002<\/p>\n<h3 class=\"ds-markdown-paragraph\"><span class=\"ez-toc-section\" id=\"04%E3%80%81%E6%9C%89%E5%8A%A9%E4%BA%8E%E5%87%8F%E5%B0%91%E5%A4%96%E6%BA%90%E6%80%A7%E9%99%8D%E7%B3%96%E8%8D%AF%E7%89%A9%E4%BE%9D%E8%B5%96%EF%BC%8C%E4%BD%86%E7%96%97%E6%95%88%E5%AD%98%E5%9C%A8%E5%BC%82%E8%B4%A8%E6%80%A7\"><\/span><strong>04\u3001\u6709\u52a9\u4e8e\u51cf\u5c11\u5916\u6e90\u6027\u964d\u7cd6\u836f\u7269\u4f9d\u8d56\uff0c\u4f46\u7597\u6548\u5b58\u5728\u5f02\u8d28\u6027<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u4e34\u5e8a\u7814\u7a76\u663e\u793a\u4e0d\u540c\u8f93\u6ce8\u65b9\u6848\u4e0bUC-MSCs\u5bf9T2DM\u7684\u7597\u6548\u5b58\u5728\u5dee\u5f02\uff1a\u4e00\u9879\u91c7\u7528\u9759\u8109\u8054\u5408\u80f0\u817a\u8840\u7ba1\u5185\u6ce8\u5c04 (\u95f4\u96945\u5929) \u7684\u7814\u7a76\u8868\u660e\uff0c\u6cbb\u75976\u4e2a\u6708\u540e\u60a3\u8005HbA1c\u53ca\u80f0\u5c9b\u7d20\u7528\u91cf\u663e\u8457\u4e0b\u964d 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(\u95f4\u96942\u5468)\uff0c\u5728\u226524\u4e2a\u6708\u968f\u8bbf\u671f\u51853\u4f8b\u4e8e25~43\u4e2a\u6708\u95f4\u5b8c\u5168\u505c\u7528\u80f0\u5c9b\u7d20\uff0c\u5176\u4f59\u60a3\u8005\u867d\u9700\u6301\u7eed\u6ce8\u5c04\u4f46\u5242\u91cf\u51cf\u5c11\u3002\u7efc\u5408\u8868\u660eUC-MSCs\u6cbb\u7597T2DM\u5177\u6709\u6f5c\u5728\u4e34\u5e8a\u4ef7\u503c\uff0c\u4f46\u5404\u7814\u7a76\u4e2d\u80f0\u5c9b\u7d20\u9700\u6c42\u6539\u5584\u7a0b\u5ea6\u53ca\u7ef4\u6301\u65f6\u957f\u5b58\u5728\u663e\u8457\u5f02\u8d28\u6027\u3002<\/p>\n<p>\u5728\u672c\u75c5\u4f8b\u4e2d\uff0c<strong>\u60a3\u8005\u8f93\u6ce8hUC-MSCs\u540e\u5b9e\u73b0\u7f13\u6162\u51cf\u836f\uff0c\u5230\u7b2c\u56db\u5468\u5b9e\u73b0\u4e86\u51cf\u505c\u53e3\u670d\u964d\u7cd6\u836f\u7269\uff0c\u5230 4 \u5468\u80f0\u5c9b\u7d20\u7528\u91cf\u8f83\u57fa\u7ebf\u80f0\u5c9b\u7d20\u7528\u91cf\u4e0b\u964d &gt; 50%<\/strong>\u3002hUC-MSCs \u6cbb\u7597\u964d\u4f4e T2DM \u60a3\u8005\u5916\u6e90\u6027\u80f0\u5c9b\u7d20\u9700\u6c42\u7684\u6f5c\u5728\u673a\u5236\u5177\u6709\u591a\u9776\u70b9\u7279\u6027\uff1a<\/p>\n<ul>\n<li>\u4e00\u65b9\u9762\u901a\u8fc7\u5f52\u5de2\u6548\u5e94\u5b9a\u5411\u8fc1\u79fb\u81f3\u53d7\u635f\u80f0\u817a\u7ec4\u7ec7\uff0c\u5206\u5316\u4e3a\u80f0\u5c9b\u7d20\u751f\u6210\u7ec6\u80de (IPCs) \u5e76\u4fc3\u8fdb\u5c40\u90e8\u7ec4\u7ec7\u4fee\u590d\uff1b<\/li>\n<li>\u53e6\u4e00\u65b9\u9762\u5206\u6ccc\u6297\u708e\u56e0\u5b50\u4e0e\u514d\u75ab\u8c03\u8282\u56e0\u5b50\uff0c\u901a\u8fc7\u65c1\u5206\u6ccc\u9014\u5f84\u6539\u5584\u80f0\u5c9b\u5fae\u73af\u5883\u3002\u540c\u65f6\u53ef\u80fd\u901a\u8fc7\u4e09\u91cd\u534f\u540c\u4f5c\u7528\u51cf\u5c11\u964d\u7cd6\u836f\u7269\u4f9d\u8d56\uff1a\u7f13\u89e3 \u03b2 \u7ec6\u80de\u529f\u80fd\u969c\u788d\u3001\u589e\u5f3a\u80f0\u5c9b \u03b2 \u7ec6\u80de\u4fdd\u62a4\u6548\u5e94\u3001\u7cfb\u7edf\u6027\u6539\u5584\u80f0\u5c9b\u7d20\u62b5\u6297\u72b6\u6001\u3002<\/li>\n<\/ul>\n<\/div>\n<h2 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