{"id":19196,"date":"2025-09-25T04:01:31","date_gmt":"2025-09-24T12:01:31","guid":{"rendered":"https:\/\/www.hjtdsm.cn\/stem-cells\/stem-cell-therapy\/19196.html"},"modified":"2025-10-11T14:31:19","modified_gmt":"2025-10-11T06:31:19","slug":"https-www-hjtdsm-cn-stem-cells-stem-cell-therapy-19196-html","status":"publish","type":"post","link":"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/19196.html","title":{"rendered":"Reshaping the future of neurodegenerative disease treatment: advances in clinical translation of stem cells and engineered exosomes"},"content":{"rendered":"<p>\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\uff0c\u5982\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\uff08AD\uff09\u3001\u5e15\u91d1\u68ee\u75c5\uff08PD\uff09\u548c\u808c\u840e\u7f29\u4fa7\u7d22\u786c\u5316\u75c7\uff08ALS\uff09\uff0c\u4e00\u76f4\u662f\u73b0\u4ee3\u533b\u5b66\u9762\u4e34\u7684\u91cd\u5927\u6311\u6218\u3002\u968f\u7740\u4eba\u53e3\u8001\u9f84\u5316\u52a0\u901f\uff0c\u8fd9\u7c7b\u75be\u75c5\u7684\u60a3\u75c5\u7387\u9010\u5e74\u6500\u5347\uff0c\u4e0d\u4ec5\u4e25\u91cd\u5f71\u54cd\u60a3\u8005\u7684\u751f\u6d3b\u8d28\u91cf\uff0c\u4e5f\u7ed9\u793e\u4f1a\u533b\u7597\u4f53\u7cfb\u5e26\u6765\u6c89\u91cd\u8d1f\u62c5\u3002\u5c3d\u7ba1\u8fc7\u53bb\u51e0\u5341\u5e74\u95f4\uff0c\u7814\u7a76\u8005\u4eec\u5728\u75c5\u7406\u673a\u5236\u63a2\u7d22\u548c\u836f\u7269\u7814\u53d1\u65b9\u9762\u53d6\u5f97\u4e86\u8bf8\u591a\u8fdb\u5c55\uff0c\u4f46\u76ee\u524d\u7684\u6cbb\u7597\u624b\u6bb5\u5927\u591a\u4ecd\u505c\u7559\u5728\u7f13\u89e3\u75c7\u72b6\u5c42\u9762\uff0c\u771f\u6b63\u80fd\u591f\u5ef6\u7f13\u751a\u81f3\u9006\u8f6c\u75be\u75c5\u8fdb\u7a0b\u7684\u7597\u6cd5\u4ecd\u663e\u532e\u4e4f\u3002<\/p>\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/09\/20250924200125-68d3dd95ad88f.jpg\" alt=\"\" title=\"\"><\/figure>\n<p>\u5728\u8fd9\u79cd\u80cc\u666f\u4e0b\uff0c<a href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/19199.html\/\" target=\"_blank\" rel=\"noopener\">stem cell therapy<\/a>\u548c\u5de5\u7a0b\u5316\u5916\u6ccc\u4f53\u9010\u6e10\u8d70\u5165\u516c\u4f17\u4e0e\u5b66\u754c\u7684\u89c6\u91ce\uff0c\u4ee3\u8868\u7740\u4e00\u79cd\u65b0\u7684\u6cbb\u7597\u8303\u5f0f\u3002\u5e72\u7ec6\u80de\u79fb\u690d\u4e3a\u4fee\u590d\u53d7\u635f\u795e\u7ecf\u7ec4\u7ec7\u63d0\u4f9b\u4e86\u53ef\u80fd\uff0c\u800c\u5916\u6ccc\u4f53\u4f5c\u4e3a\u7ec6\u80de\u95f4\u901a\u8baf\u7684\u91cd\u8981\u5a92\u4ecb\uff0c\u6b63\u88ab\u8d4b\u4e88\u836f\u7269\u9012\u9001\u4e0e\u795e\u7ecf\u4fdd\u62a4\u7684\u65b0\u4f7f\u547d\u3002\u4e8c\u8005\u7684\u7ed3\u5408\uff0c\u6216\u8bb8\u6b63\u9884\u793a\u7740\u672a\u6765\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u6cbb\u7597\u7684\u65b9\u5411\u3002<\/p>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_79_2 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewbox=\"0 0 24 24\" version=\"1.2\" baseprofile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1' ><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/19196.html\/#%E9%87%8D%E5%A1%91%E7%A5%9E%E7%BB%8F%E9%80%80%E8%A1%8C%E6%80%A7%E7%96%BE%E7%97%85%E6%B2%BB%E7%96%97%E7%9A%84%E6%9C%AA%E6%9D%A5%EF%BC%9A%E5%B9%B2%E7%BB%86%E8%83%9E%E4%B8%8E%E5%B7%A5%E7%A8%8B%E5%8C%96%E5%A4%96%E6%B3%8C%E4%BD%93%E7%9A%84%E4%B8%B4%E5%BA%8A%E8%BD%AC%E5%8C%96%E8%BF%9B%E5%B1%95\" >Reshaping the future of neurodegenerative disease treatment: advances in clinical translation of stem cells and engineered exosomes<\/a><ul class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/19196.html\/#%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E7%A5%9E%E7%BB%8F%E9%80%80%E8%A1%8C%E6%80%A7%E7%96%BE%E7%97%85%E7%9A%84%E6%A6%82%E8%BF%B0\" >\u5e72\u7ec6\u80de\u6cbb\u7597\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u7684\u6982\u8ff0<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/19196.html\/#%E5%90%84%E7%B1%BB%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E7%9A%84%E5%BA%94%E7%94%A8%E4%B8%8E%E6%8C%91%E6%88%98\" >\u5404\u7c7b\u5e72\u7ec6\u80de\u6cbb\u7597\u7684\u5e94\u7528\u4e0e\u6311\u6218<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/19196.html\/#%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E4%BE%9B%E4%BD%93%E6%9D%A5%E6%BA%90%E9%80%89%E6%8B%A9\" >\u5e72\u7ec6\u80de\u6cbb\u7597\u4f9b\u4f53\u6765\u6e90\u9009\u62e9<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/19196.html\/#%E5%B9%B2%E7%BB%86%E8%83%9E%E5%A4%96%E6%B3%8C%E4%BD%93%E5%9C%A8%E7%A5%9E%E7%BB%8F%E9%80%80%E8%A1%8C%E6%80%A7%E7%96%BE%E7%97%85%E4%B8%AD%E7%9A%84%E7%89%B9%E5%BE%81%E4%B8%8E%E5%8A%9F%E8%83%BD\" >\u5e72\u7ec6\u80de\u5916\u6ccc\u4f53\u5728\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u4e2d\u7684\u7279\u5f81\u4e0e\u529f\u80fd<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/19196.html\/#%E5%B9%B2%E7%BB%86%E8%83%9E%E5%A4%96%E6%B3%8C%E4%BD%93%E5%9C%A8%E6%B2%BB%E7%96%97%E7%A5%9E%E7%BB%8F%E9%80%80%E8%A1%8C%E6%80%A7%E7%96%BE%E7%97%85%E4%B8%AD%E7%9A%84%E6%BD%9C%E5%8A%9B\" >\u5e72\u7ec6\u80de\u5916\u6ccc\u4f53\u5728\u6cbb\u7597\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u4e2d\u7684\u6f5c\u529b<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/19196.html\/#%E5%B9%B2%E7%BB%86%E8%83%9E%E5%A4%96%E6%B3%8C%E4%BD%93%E6%B2%BB%E7%96%97%E9%98%BF%E5%B0%94%E8%8C%A8%E6%B5%B7%E9%BB%98%E7%97%85\" >\u5e72\u7ec6\u80de\u5916\u6ccc\u4f53\u6cbb\u7597\u963f\u5c14\u8328\u6d77\u9ed8\u75c5<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/19196.html\/#%E5%B9%B2%E7%BB%86%E8%83%9E%E5%A4%96%E6%B3%8C%E4%BD%93%E6%B2%BB%E7%96%97%E5%B8%95%E9%87%91%E6%A3%AE%E7%97%85\" >\u5e72\u7ec6\u80de\u5916\u6ccc\u4f53\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/19196.html\/#%E5%B9%B2%E7%BB%86%E8%83%9E%E5%A4%96%E6%B3%8C%E4%BD%93%E6%B2%BB%E7%96%97%E8%90%8E%E7%BC%A9%E4%BE%A7%E7%B4%A2%E7%A1%AC%E5%8C%96%E7%97%87\" >\u5e72\u7ec6\u80de\u5916\u6ccc\u4f53\u6cbb\u7597\u840e\u7f29\u4fa7\u7d22\u786c\u5316\u75c7<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/19196.html\/#%E5%B9%B2%E7%BB%86%E8%83%9E%E5%A4%96%E6%B3%8C%E4%BD%93%E6%B2%BB%E7%96%97%E4%BA%A8%E5%BB%B7%E9%A1%BF%E8%88%9E%E8%B9%88%E7%97%87\" >\u5e72\u7ec6\u80de\u5916\u6ccc\u4f53\u6cbb\u7597\u4ea8\u5ef7\u987f\u821e\u8e48\u75c7<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/19196.html\/#%E5%B9%B2%E7%BB%86%E8%83%9E%E6%9D%A5%E6%BA%90%E7%9A%84%E5%A4%96%E6%B3%8C%E4%BD%93%E5%9C%A8ND%E4%B8%AD%E7%9A%84%E4%B8%B4%E5%BA%8A%E8%AF%95%E9%AA%8C\" >\u5e72\u7ec6\u80de\u6765\u6e90\u7684\u5916\u6ccc\u4f53\u5728ND\u4e2d\u7684\u4e34\u5e8a\u8bd5\u9a8c<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/19196.html\/#%E7%BB%93%E8%AE%BA%E4%B8%8E%E6%9C%AA%E6%9D%A5%E5%B1%95%E6%9C%9B\" >\u7ed3\u8bba\u4e0e\u672a\u6765\u5c55\u671b<\/a><\/li><\/ul><\/li><\/ul><\/nav><\/div>\n<h1><span class=\"ez-toc-section\" id=\"%E9%87%8D%E5%A1%91%E7%A5%9E%E7%BB%8F%E9%80%80%E8%A1%8C%E6%80%A7%E7%96%BE%E7%97%85%E6%B2%BB%E7%96%97%E7%9A%84%E6%9C%AA%E6%9D%A5%EF%BC%9A%E5%B9%B2%E7%BB%86%E8%83%9E%E4%B8%8E%E5%B7%A5%E7%A8%8B%E5%8C%96%E5%A4%96%E6%B3%8C%E4%BD%93%E7%9A%84%E4%B8%B4%E5%BA%8A%E8%BD%AC%E5%8C%96%E8%BF%9B%E5%B1%95\"><\/span><strong>Reshaping the future of neurodegenerative disease treatment: advances in clinical translation of stem cells and engineered exosomes<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h1>\n<p>\u8fd1\u65e5\uff0c\u56fd\u9645\u671f\u520a\u300a<a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1111\/cns.70577\" target=\"_blank\" rel=\"nofollow noopener\">\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u6cbb\u7597<\/a>\u300b\u6742\u5fd7\u53d1\u8868\u7684\u4e00\u7bc7\u6587\u732e\u7efc\u8ff0\uff0c\u7cfb\u7edf\u56de\u987e\u4e86\u201c\u5e72\u7ec6\u80de\u548c\u5916\u6ccc\u4f53\u6cbb\u7597\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u7684\u4e34\u5e8a\u8bd5\u9a8c\u8fdb\u5c55\u548c\u524d\u666f\u201d\u3002\u8be5\u7efc\u8ff0\u5bf994\u9879\u9488\u5bf9AD\u3001PD\u3001ALS\u548c\u4ea8\u5ef7\u987f\u75c5\uff08HD\uff09\u7684\u5e72\u7ec6\u80de\u4e34\u5e8a\u8bd5\u9a8c\u8fdb\u884c\u4e86\u8bc4\u4f30\uff0c\u5e76\u63a2\u8ba8\u4e86\u57fa\u4e8e\u5e72\u7ec6\u80de\u6765\u6e90\u5916\u6ccc\u4f53\u7684\u65b0\u5174\u7597\u6cd5<sup>[1]<\/sup>The<\/p>\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/09\/20250924200125-68d3dd95bb6cc.png\" alt=\"\" title=\"\"><figcaption><\/figcaption><\/figure>\n<p>\u5176\u7ed3\u679c\u8868\u660e\uff0c<strong>\u5916\u6ccc\u4f53\u80fd\u591f\u7a7f\u8d8a<\/strong><strong>blood-brain barrier<\/strong><strong>\uff0c\u5c06\u6cbb\u7597\u5206\u5b50\u76f4\u63a5\u9012\u9001\u81f3\u8111\u90e8\uff0c\u4e3a\u5e72\u7ec6\u80de\u79fb\u690d\u63d0\u4f9b\u4e86\u4e00\u79cd\u4fb5\u5165\u6027\u66f4\u4f4e\u7684\u66ff\u4ee3\u65b9\u6848<\/strong>\u3002\u5c24\u5176\u662f<strong><span class=\"xintheme_tag_link\">mesenchymal stem cell MSC (in cell biology)<\/span>\uff08MSC\uff09\u6765\u6e90\u7684\u5916\u6ccc\u4f53\uff0c\u5728\u4e34\u5e8a\u524d\u6a21\u578b\u4e2d\u5c55\u73b0\u51fa\u51cf\u5c11\u795e\u7ecf\u708e\u75c7\u3001\u6c27\u5316\u5e94\u6fc0\u548c\u4fc3\u8fdb\u795e\u7ecf\u5143\u518d\u751f\u7684\u6f5c\u529b<\/strong>The<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E7%A5%9E%E7%BB%8F%E9%80%80%E8%A1%8C%E6%80%A7%E7%96%BE%E7%97%85%E7%9A%84%E6%A6%82%E8%BF%B0\"><\/span><strong>\u5e72\u7ec6\u80de\u6cbb\u7597\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u7684\u6982\u8ff0<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>\u5e72\u7ec6\u80de\u7597\u6cd5\u901a\u8fc7\u4fee\u590d\u53d7\u635f\u8111\u7ec4\u7ec7\u548c\u51cf\u7f13\u75c5\u60c5\u8fdb\u5c55\uff0c\u4e3a\u6cbb\u7597\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\uff08ND\uff09\u5e26\u6765\u4e86\u65b0\u7684\u5e0c\u671b\u3002\u591a\u79cd\u5e72\u7ec6\u80de\u7c7b\u578b\uff0c\u5305\u62ec\u795e\u7ecf\u5e72\u7ec6\u80de\uff08NSC\uff09\u3001\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSC\uff09\u3001\u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de\uff08iPSC\uff09\u548c\u80da\u80ce\u5e72\u7ec6\u80de\uff08ESC\uff09\uff0c\u5df2\u88ab\u8bc1\u5b9e\u80fd\u591f\u66ff\u6362\u4e22\u5931\u7684\u795e\u7ecf\u5143\u3001\u4fee\u590d\u53d7\u635f\u8111\u56de\u8def\u5e76\u6574\u5408\u5165\u8111\u7ec4\u7ec7\uff0c\u4ece\u800c\u6539\u5584\u60a3\u8005\u7684\u8ba4\u77e5\u4e0e\u8fd0\u52a8\u529f\u80fd\u3002<\/p>\n<p><strong>\u4e34\u5e8a\u8bd5\u9a8c\u6982\u51b5\uff1a<\/strong>\u4e3a\u7cfb\u7edf\u5206\u6790\u8be5\u9886\u57df\u7684\u4e34\u5e8a\u7814\u7a76\u8fdb\u5c55\uff0c<strong>\u6211\u4eec\u4eceClinicalTrials.gov\u6570\u636e\u5e93\u7b5b\u9009\u51fa94\u9879\u76f8\u5173\u8bd5\u9a8c<\/strong>\u3002\u7b5b\u9009\u8fc7\u7a0b\u57fa\u4e8e\u7279\u5b9a\u75be\u75c5\u5173\u952e\u8bcd\u641c\u7d22\uff0c\u5e76\u4e25\u683c\u6392\u9664\u4e86\u672a\u4f7f\u7528\u5e72\u7ec6\u80de\u7597\u6cd5\u53ca\u5904\u4e8e\u6682\u505c\u3001\u7ec8\u6b62\u7b49\u72b6\u6001\u7684\u7814\u7a76\u3002<\/p>\n<p>\u6700\u7ec8\u7eb3\u5165\u7684\u8bd5\u9a8c\u6839\u636e\u62db\u52df\u72b6\u6001\u88ab\u5206\u7c7b\u4e3a\u201c\u5df2\u5b8c\u6210\u201d\u6216\u201c\u6b63\u5728\u8fdb\u884c\u201d\uff0c\u5e76\u6309\u4e34\u5e8a\u9636\u6bb5\uff08\u5305\u62ec\u672a\u77e5\u9636\u6bb5NA\uff09\u8fdb\u884c\u5f52\u7eb3\uff0c\u4ece\u800c\u6e05\u6670\u5c55\u793a\u4e86<span class=\"xintheme_tag_link\">stem cell therapy<\/span>\u5404\u7c7b\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u6240\u8fbe\u5230\u7684\u6700\u65b0\u7814\u53d1\u9636\u6bb5\u3002<\/p>\n<p>\u4f7f\u7528\u5e72\u7ec6\u80de\u6cbb\u7597\u4e0a\u8ff0ND\u7684\u521d\u59cb\u4e34\u5e8a\u8bd5\u9a8c\u59cb\u4e8e2007\u5e74\uff0c\u9996\u5148\u662fALS\uff0c\u968f\u540e2011\u5e74\u662fAD\u548cPD\uff0c\u540e\u6765\u57282014\u5e74\u662fHD\u3002\u8fd9\u4e9b\u8bd5\u9a8c\u4e3b\u8981\u96c6\u4e2d\u4e8e\u8bc4\u4f30\u5e72\u7ec6\u80de\u5728ND\u4e2d\u7684\u6548\u679c\uff0c\u5e76\u65e8\u5728\u8bc4\u4f30\u901a\u8fc7\u5404\u79cd\u8f93\u9001\u65b9\u5f0f\uff08\u5305\u62ec\u9759\u8109\u5185\u6216\u9798\u5185\u6ce8\u5c04\u4ee5\u53ca\u76f4\u63a5\u79fb\u690d\u5230\u8111\u5185\uff09\u5c06\u5e72\u7ec6\u80de\u79fb\u690d\u5230\u60a3\u8005\u4f53\u5185\u7684\u5b89\u5168\u6027\u548c\u53ef\u884c\u6027\u3002<\/p>\n<p>\u572894\u9879\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u5982\u679c\u6211\u4eec\u5ffd\u7565\u90a3\u4e9b\u7814\u7a76\u72b6\u6001\u672a\u77e5\u7684\uff0c\u5219\u603b\u5171\u67093\u98793\u671f\u8bd5\u9a8c\uff081\u9879\u9488\u5bf9ALS\u5df2\u5b8c\u6210\u30011\u9879\u6b63\u5728\u8fdb\u884c\uff0c1\u9879\u9488\u5bf9HD\u6b63\u5728\u8fdb\u884c\uff09\uff0c10\u98792\u671f\u8bd5\u9a8c\uff082\u9879\u9488\u5bf9AD\u6b63\u5728\u8fdb\u884c\uff0c2\u9879\u9488\u5bf9PD\u5df2\u5b8c\u6210\u30011\u9879\u6b63\u5728\u8fdb\u884c\uff0c2\u9879\u9488\u5bf9ALS\u5df2\u5b8c\u6210\u30012\u9879\u6b63\u5728\u8fdb\u884c\uff0c1\u9879\u9488\u5bf9HD\u5df2\u5b8c\u6210\uff09\uff0c\u4ee5\u53ca1\u9879\u9488\u5bf9ALS\u5df2\u5b8c\u6210\u76842\/3\u671f\u8bd5\u9a8c\u3002\u5176\u4f59\u5927\u90e8\u5206\u4e3a1\u671f\u548c1\/2\u671f\u8bd5\u9a8c\uff0c\u4ee5\u53ca\u5c11\u6570\u65e9\u671f\u8bd5\u9a8c\uff08\u56fe1\uff09\u3002<\/p>\n<figure class=\"wp-block-image size-full\">\n<p><div style=\"width: 2138px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/09\/20250924200125-68d3dd95d7126.jpg\" alt=\"\u56fe1\uff1a\u6570\u636e\u663e\u793aAD\u3001PD\u3001ALS\u548cHD\u7684\u5e72\u7ec6\u80de\u4e34\u5e8a\u8bd5\u9a8c\u72b6\u51b5\uff0c\u6309\u9636\u6bb5\u5206\u7c7b\uff0c\u4ee5\u53ca\u6bcf\u79cd\u75be\u75c5\u6240\u5904\u7684\u6700\u8fdc\u9636\u6bb5\uff0c\u5982\u5728clinicaltrials.gov\u4e0a\u6ce8\u518c\u7684\u3002\" width=\"2128\" height=\"1598\" title=\"\"><p class=\"wp-caption-text\">\u56fe1\uff1a\u6570\u636e\u663e\u793aAD\u3001PD\u3001ALS\u548cHD\u7684\u5e72\u7ec6\u80de\u4e34\u5e8a\u8bd5\u9a8c\u72b6\u51b5\uff0c\u6309\u9636\u6bb5\u5206\u7c7b\uff0c\u4ee5\u53ca\u6bcf\u79cd\u75be\u75c5\u6240\u5904\u7684\u6700\u8fdc\u9636\u6bb5\uff0c\u5982\u5728clinicaltrials.gov\u4e0a\u6ce8\u518c\u7684\u3002<\/p><\/div><figcaption><\/figcaption><\/figure>\n<p><strong>\u603b\u8ba1\u6709\u8d85\u8fc78000\u540d\u53c2\u4e0e\u8005\uff08\u60a3\u8005\u548c\u5065\u5eb7\u5bf9\u7167\u8005\uff09\u53c2\u52a0\u4e86\u8fd9\u56db\u79cd\u75be\u75c5\u7684\u5e72\u7ec6\u80de\u6cbb\u7597\u8bd5\u9a8c\u3002<\/strong>\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u5176\u4e2d\u8fd170%\u7684\u53c2\u4e0e\u8005\u53c2\u52a0\u4e86AD\u8bd5\u9a8c\uff08\u56fe2\uff09\u3002<\/p>\n<figure class=\"wp-block-image size-full\">\n<p><div style=\"width: 1994px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/09\/20250924200126-68d3dd96c2b83.jpg\" alt=\"\u56fe2\uff1a\u5728clinicaltrials.gov\u4e0a\u6ce8\u518c\u7684AD\u3001PD\u3001ALS\u548cHD\u5e72\u7ec6\u80de\u6cbb\u7597\u4e34\u5e8a\u8bd5\u9a8c\u53c2\u4e0e\u8005\u7684\u5206\u5e03\u60c5\u51b5\u3002\" width=\"1984\" height=\"1884\" title=\"\"><p class=\"wp-caption-text\">\u56fe2\uff1a\u5728clinicaltrials.gov\u4e0a\u6ce8\u518c\u7684AD\u3001PD\u3001ALS\u548cHD\u5e72\u7ec6\u80de\u6cbb\u7597\u4e34\u5e8a\u8bd5\u9a8c\u53c2\u4e0e\u8005\u7684\u5206\u5e03\u60c5\u51b5\u3002<\/p><\/div><figcaption><\/figcaption><\/figure>\n<h2><span class=\"ez-toc-section\" id=\"%E5%90%84%E7%B1%BB%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E7%9A%84%E5%BA%94%E7%94%A8%E4%B8%8E%E6%8C%91%E6%88%98\"><\/span><strong>\u5404\u7c7b\u5e72\u7ec6\u80de\u6cbb\u7597\u7684\u5e94\u7528\u4e0e\u6311\u6218<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><strong><a href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/nsc\/19236.html\/\" target=\"_blank\" rel=\"noopener\">Neural Stem Cells (NSC)<\/a>::<\/strong>\u5728\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf (CNS) \u7684\u53d1\u80b2\u8fc7\u7a0b\u4e2d\uff0c\u795e\u7ecf\u5e72\u7ec6\u80de (NSC) \u5177\u6709\u72ec\u7279\u7684\u81ea\u6211\u66f4\u65b0\u80fd\u529b\uff0c\u80fd\u591f\u5206\u5316\u6210\u795e\u7ecf\u5143\u548c\u795e\u7ecf\u80f6\u8d28\u7ec6\u80de\uff0c\u8fd9\u4f7f\u5176\u7279\u522b\u9002\u5408\u7528\u4e8e\u6cbb\u7597\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5 (ND) \u3002\u5df2\u8bc1\u660e<strong>NSC\u79fb\u690d\u53ef\u901a\u8fc7\u5404\u79cd\u673a\u5236\u9884\u9632\u795e\u7ecf\u9000\u884c\u6027\u53d8\u5e76\u4fc3\u8fdb\u518d\u751f\uff0c\u5305\u62ec\u589e\u5f3a\u795e\u7ecf\u5143\u53ef\u5851\u6027\u3001\u51cf\u5c11\u795e\u7ecf\u708e\u75c7\u3001\u4ea7\u751f\u795e\u7ecf\u8425\u517b\u56e0\u5b50\u4ee5\u53ca\u4fee\u590d\u6b7b\u4ea1\u7ec6\u80de<\/strong>The<\/p>\n<p>\u7136\u800c\uff0c\u5b83\u4eec\u7684\u4f7f\u7528\u4e5f\u6709\u5c40\u9650\u6027\u3002NSC\u4e3b\u8981\u5b58\u5728\u4e8e\u6210\u4eba\u5927\u8111\u7684\u7279\u5b9a\u533a\u57df\uff0c\u56e0\u6b64\u4ece\u6d3b\u4f53\u6350\u732e\u8005\u5904\u83b7\u53d6\u5b83\u4eec\u7528\u4e8e\u6cbb\u7597\u76ee\u7684\u5e76\u4e0d\u5207\u5b9e\u9645\u3002\u6b64\u5916\uff0c\u4ece\u80ce\u513f\u5927\u8111\u4e2d\u83b7\u53d6NSC\u4f1a\u5f15\u53d1\u6709\u5173\u53ef\u80fd\u5229\u7528\u4eba\u7c7b\u80ce\u513f\u7684\u4f26\u7406\u62c5\u5fe7\u3002<\/p>\n<p><strong>\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSC\uff09\uff1a<\/strong>MSC\u901a\u5e38\u6765\u6e90\u4e8e\u9aa8\u9ad3\u3001\u8102\u80aa\u7ec4\u7ec7\u6216\u8110\u5e26\u7ec4\u7ec7\uff0c\u662f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u4f7f\u7528\u6700\u5e7f\u6cdb\u7684\u5e72\u7ec6\u80de\u4e4b\u4e00\uff08\u56fe3A\u3001B\uff09\uff0c\u56e0\u4e3a\u5b83\u4eec\u80fd\u591f\u6539\u53d8\u5c40\u90e8\u5fae\u73af\u5883\u3001\u652f\u6301\u795e\u7ecf\u53d1\u751f\u3001\u4fc3\u8fdb\u7ec6\u80de\u4fee\u590d\u548c\u8c03\u8282\u514d\u75ab\u53cd\u5e94\uff0c\u4ece\u800c\u53ef\u80fd\u6539\u5584\u8ba4\u77e5\u548c\u8fd0\u52a8\u529f\u80fd\u3002\u5b83\u4eec\u7684\u514d\u75ab\u8c03\u8282\u4f5c\u7528\u548c\u8425\u517b\u56e0\u5b50\u7684\u5206\u6ccc\u4f7f\u5176\u6210\u4e3a\u6cbb\u7597ND\u7684\u6709\u5438\u5f15\u529b\u7684\u9009\u62e9\uff0c\u6709\u53ef\u80fd\u7f13\u89e3\u795e\u7ecf\u708e\u75c7\u5e76\u589e\u5f3a\u7ec4\u7ec7\u4fee\u590d\u3002MSC\u901a\u5e38\u88ab\u8ba4\u4e3a\u5177\u6709\u826f\u597d\u7684\u5b89\u5168\u6027\uff0c\u56e0\u4e3a\u5b83\u4eec\u4e0d\u6613\u5f62\u6210\u80bf\u7624\uff0c\u5e76\u4e14\u53ef\u7528\u4e8e\u81ea\u4f53\u7597\u6cd5\u4ee5\u51cf\u8f7b\u514d\u75ab\u6392\u65a5\u53cd\u5e94\u3002<\/p>\n<p>\u4f46\u5176\u4e34\u5e8a\u5e94\u7528\u4ecd\u9762\u4e34\u6311\u6218\uff1a\u5305\u62ec\u79fb\u690d\u540e\u7ec6\u80de\u5b58\u6d3b\u7387\u4f4e\u3001\u5b9a\u5411\u5206\u5316\u4e3a\u795e\u7ecf\u7ec6\u80de\u56f0\u96be\uff0c\u4ee5\u53ca\u53ef\u80fd\u56e0\u53cd\u590d\u6ce8\u5c04\u6216MHC I\u7c7b\u5206\u5b50\u8868\u8fbe\u5f15\u53d1\u514d\u75ab\u53cd\u5e94\u7684\u98ce\u9669\u3002<\/p>\n<figure class=\"wp-block-image size-full\">\n<p><div style=\"width: 2138px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/09\/20250924200127-68d3dd977fc7d.jpg\" alt=\"\u56fe3\uff1a(A) \u5728clinicaltrials.gov\u4e0a\u6ce8\u518c\u7684AD\u3001PD\u3001ALS\u548cHD\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u4f7f\u7528\u7684\u5e72\u7ec6\u80de\u7c7b\u578b\u5206\u5e03\u3002(B) \u5728clinicaltrials.gov\u4e0a\u6ce8\u518c\u7684AD\u3001PD\u3001ALS\u548cHD\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u4f7f\u7528\u7684\u5e72\u7ec6\u80de\u5206\u79bb\u6765\u6e90\u3002\" width=\"2128\" height=\"2545\" title=\"\"><p class=\"wp-caption-text\">\u56fe3\uff1a(A) \u5728clinicaltrials.gov\u4e0a\u6ce8\u518c\u7684AD\u3001PD\u3001ALS\u548cHD\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u4f7f\u7528\u7684\u5e72\u7ec6\u80de\u7c7b\u578b\u5206\u5e03\u3002(B) \u5728clinicaltrials.gov\u4e0a\u6ce8\u518c\u7684AD\u3001PD\u3001ALS\u548cHD\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u4f7f\u7528\u7684\u5e72\u7ec6\u80de\u5206\u79bb\u6765\u6e90\u3002<\/p><\/div><figcaption><\/figcaption><\/figure>\n<p><strong>\u80da\u80ce\u5e72\u7ec6\u80de\uff08ESC\uff09\uff1a<\/strong>\u80da\u80ce\u5e72\u7ec6\u80de\uff08ESC\uff09\u56e0\u5176\u5177\u6709\u5206\u5316\u4e3a\u6240\u6709\u7ec6\u80de\u7c7b\u578b\u7684\u5f3a\u5927\u6f5c\u529b\u800c\u5907\u53d7\u5173\u6ce8\uff0c\u4f46\u53d7\u9650\u4e8e\u4f26\u7406\u4e89\u8bae\uff0c\u5176\u5728\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\uff08ND\uff09\u9886\u57df\u7684\u4e34\u5e8a\u8bd5\u9a8c\u6570\u91cf\u8f83\u5c11\uff0c\u76ee\u524d\u4ec5\u67096\u9879\uff0c\u4e3b\u8981\u96c6\u4e2d\u4e8e\u5e15\u91d1\u68ee\u75c5\uff08PD\uff09\u548c\u808c\u840e\u7f29\u4fa7\u7d22\u786c\u5316\u75c7\uff08ALS\uff09\u3002<\/p>\n<p><strong>\u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de\uff08iPSC\uff09\uff1a<\/strong>\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de\uff08iPSC\uff09\u901a\u8fc7\u91cd\u7f16\u7a0b\u4f53\u7ec6\u80de\u83b7\u5f97\uff0c\u5728\u4fdd\u7559\u591a\u80fd\u6027\u7684\u540c\u65f6\u6709\u6548\u89c4\u907f\u4e86\u4f26\u7406\u95ee\u9898\uff0c\u5df2\u6210\u4e3a\u66f4\u5177\u5e94\u7528\u524d\u666f\u7684\u66ff\u4ee3\u7b56\u7565\uff1b\u73b0\u6709\u4e34\u5e8a\u8bd5\u9a8c\u4e3b\u8981\u56f4\u7ed5PD\u5c55\u5f00\uff0c\u901a\u8fc7\u5c06iPSC\u5206\u5316\u4e3a\u591a\u5df4\u80fa\u80fd\u7956\u7ec6\u80de\u8fdb\u884c\u8111\u5185\u79fb\u690d\uff0c\u4e14\u7814\u7a76\u65b9\u5411\u6b63\u9010\u6e10\u62d3\u5c55\u81f3\u57fa\u4e8eiPSC\u7684\u5916\u6ccc\u4f53\u7597\u6cd5\uff0c\u4ee5\u63d0\u5347\u5206\u5316\u7684\u53ef\u63a7\u6027\u5e76\u964d\u4f4e\u514d\u75ab\u98ce\u9669\u3002<\/p>\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E4%BE%9B%E4%BD%93%E6%9D%A5%E6%BA%90%E9%80%89%E6%8B%A9\"><\/span><strong>\u5e72\u7ec6\u80de\u6cbb\u7597\u4f9b\u4f53\u6765\u6e90\u9009\u62e9<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u5e72\u7ec6\u80de\u4f9b\u4f53\u6765\u6e90\u4e3b\u8981\u5305\u62ec\u81ea\u4f53\uff08\u6765\u81ea\u60a3\u8005\u81ea\u8eab\uff09\u548c\u5f02\u4f53\uff08\u6765\u81ea\u4ed6\u4eba\uff09\u3002\u5f02\u4f53\u6765\u6e90\u5728AD\u548cPD\u4e2d\u8f83\u5e38\u89c1\uff0c\u53ef\u63d0\u4f9b\u66f4\u5065\u5eb7\u3001\u4e30\u5bcc\u7684\u7ec6\u80de\uff0c\u4f46\u5b58\u5728\u514d\u75ab\u6392\u65a5\u98ce\u9669\uff1b\u81ea\u4f53\u7597\u6cd5\u5728ALS\u4e2d\u5e94\u7528\u8f83\u591a\uff08\u56fe4\uff09\uff0c\u65e0\u6392\u65a5\u95ee\u9898\u4f46\u53ef\u80fd\u53d7\u60a3\u8005\u5e74\u9f84\u548c\u75c5\u60c5\u5f71\u54cd\u7ec6\u80de\u8d28\u91cf\u3002\u6700\u7ec8\u9009\u62e9\u9700\u7ed3\u5408\u75be\u75c5\u7c7b\u578b\u3001\u60a3\u8005\u72b6\u51b5\u53ca\u7ec6\u80de\u8d28\u91cf\u800c\u5b9a\u3002<\/p>\n<figure class=\"wp-block-image size-full\">\n<p><div style=\"width: 2138px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/09\/20250924200128-68d3dd98bbf67.jpg\" alt=\"\u56fe4\uff1a\u5728AD\u3001PD\u3001ALS\u548cHD\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u4f7f\u7528\u7684\u5e72\u7ec6\u80de\u7684\u6350\u8d60\u6765\u6e90\uff0c\u5df2\u5728clinicaltrials.gov\u4e0a\u6ce8\u518c\u3002\" width=\"2128\" height=\"1276\" title=\"\"><p class=\"wp-caption-text\">\u56fe4\uff1a\u5728AD\u3001PD\u3001ALS\u548cHD\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u4f7f\u7528\u7684\u5e72\u7ec6\u80de\u7684\u6350\u8d60\u6765\u6e90\uff0c\u5df2\u5728clinicaltrials.gov\u4e0a\u6ce8\u518c\u3002<\/p><\/div><figcaption><\/figcaption><\/figure>\n<h2><span class=\"ez-toc-section\" id=\"%E5%B9%B2%E7%BB%86%E8%83%9E%E5%A4%96%E6%B3%8C%E4%BD%93%E5%9C%A8%E7%A5%9E%E7%BB%8F%E9%80%80%E8%A1%8C%E6%80%A7%E7%96%BE%E7%97%85%E4%B8%AD%E7%9A%84%E7%89%B9%E5%BE%81%E4%B8%8E%E5%8A%9F%E8%83%BD\"><\/span><strong>\u5e72\u7ec6\u80de\u5916\u6ccc\u4f53\u5728\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u4e2d\u7684\u7279\u5f81\u4e0e\u529f\u80fd<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><strong>\u7279\u5f81\u4e0e\u751f\u7269\u5b66\u529f\u80fd\uff1a<\/strong>\u5728\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u7684\u80cc\u666f\u4e0b\uff0c\u5916\u6ccc\u4f53\u662f\u76f4\u5f8430-150\u7eb3\u7c73\u7684\u7ec6\u80de\u5916\u56ca\u6ce1\uff0c\u7531\u8102\u8d28\u53cc\u5c42\u819c\uff08\u542b\u9798\u78f7\u8102\u3001\u80c6\u56fa\u9187\u7b49\uff09\u6784\u6210\uff0c\u8868\u9762\u643a\u5e26CD9\u3001CD63\u3001CD81\u7b49\u86cb\u767d\u6807\u5fd7\u7269\uff0c\u5185\u90e8\u5305\u88f9miRNA\u3001\u86cb\u767d\u8d28\u7b49\u751f\u7269\u6d3b\u6027\u5206\u5b50\u3002<\/p>\n<p>\u5b83\u4eec\u5728\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u4e2d\u7ef4\u6301\u5927\u8111\u5185\u73af\u5883\u5e73\u8861\uff0c\u53c2\u4e0e\u8c03\u63a7\u7a81\u89e6\u53ef\u5851\u6027\u3001\u4fc3\u8fdb\u795e\u7ecf\u53d1\u751f\u3001\u652f\u6301\u9ad3\u9798\u5f62\u6210\u548c\u9a71\u52a8\u795e\u7ecf\u4fee\u590d\u518d\u751f\uff0c\u5e76\u901a\u8fc7\u4f20\u9012\u9057\u4f20\u4fe1\u606f\u8c03\u63a7\u57fa\u56e0\u8868\u8fbe\uff0c\u53d1\u6325\u795e\u7ecf\u4fdd\u62a4\u3001\u6291\u5236\u51cb\u4ea1\u3001\u8c03\u8282\u6c27\u5316\u5e94\u6fc0\u548c\u708e\u75c7\u53cd\u5e94\u7b49\u4f5c\u7528\u3002<\/p>\n<p><strong>\u6cbb\u7597\u6f5c\u529b\uff1a<\/strong>\u57fa\u4e8e\u5176\u529f\u80fd\uff0c\u5916\u6ccc\u4f53\uff08\u5c24\u5176\u662fMSC\u548cNSC\u6765\u6e90\uff09\u5728ND\u6cbb\u7597\u4e2d\u5c55\u73b0\u51fa\u5de8\u5927\u6f5c\u529b\u3002MSC\u5916\u6ccc\u4f53\u901a\u8fc7\u4f20\u9012VEGF\u3001TGF-\u03b2\u7b49\u56e0\u5b50\u548cmiR-21\u4fc3\u8fdb\u8840\u7ba1\u751f\u6210\u3001\u6291\u5236\u51cb\u4ea1\u548c\u51cf\u8f7b\u708e\u75c7\uff1bNSC\u5916\u6ccc\u4f53\u5219\u5bcc\u542bBDNF\u548cmiR-124\u7b49\uff0c\u76f4\u63a5\u4fc3\u8fdb\u795e\u7ecf\u5143\u5206\u5316\u3001\u7a81\u89e6\u5f62\u6210\u548c\u795e\u7ecf\u4fdd\u62a4\u3002\u5176\u5929\u7136\u7a7f\u8d8a\u8840\u8111\u5c4f\u969c\u7684\u80fd\u529b\uff0c\u4f7f\u5176\u6210\u4e3a\u6781\u5177\u524d\u666f\u7684\u65e0\u7ec6\u80de\u6cbb\u7597\u7b56\u7565\u548c\u836f\u7269\u9012\u9001\u8f7d\u4f53\u3002<\/p>\n<p><strong>\u5916\u6ccc\u4f53\u7684\u751f\u7269\u5408\u6210\uff1a<\/strong>\u5982\u56fe5\u6240\u793a \uff0c\u5916\u6ccc\u4f53\u7684\u751f\u7269\u5408\u6210\u59cb\u4e8e\u771f\u6838\u7ec6\u80de\u7684\u5185\u4f53\u7cfb\u7edf\uff0c\u59cb\u4e8e\u7ec6\u80de\u8d28\u819c\u5185\u9677\u5f62\u6210\u65e9\u671f\u5185\u4f53\u3002\u8fd9\u4e9b\u65e9\u671f\u5185\u4f53\u968f\u540e\u6210\u719f\u4e3a\u665a\u671f\u5185\u4f53\uff0c\u79f0\u4e3a\u591a\u6ce1\u4f53 (MVB)\u3002\u5728\u6b64\u6210\u719f\u8fc7\u7a0b\u4e2d\uff0c\u5185\u4f53\u819c\u5411\u5185\u51fa\u82bd\u8fdb\u5165MVB\u8154\uff0c\u5f62\u6210\u8154\u5185\u56ca\u6ce1 (ILV)\u3002MVB\u53ef\u4ee5\u4e0e\u6eb6\u9176\u4f53\u6216\u81ea\u566c\u4f53\u878d\u5408\u964d\u89e3\uff0c\u6216\u8f6c\u8fd0\u81f3\u8d28\u819c\uff0c\u5728\u90a3\u91cc\u5b83\u4eec\u878d\u5408\u5e76\u5c06ILV\u91ca\u653e\u5230\u7ec6\u80de\u5916\u73af\u5883\u4e2d\uff0c\u5f62\u6210\u5916\u6ccc\u4f53\u3002<\/p>\n<figure class=\"wp-block-image size-full\">\n<p><div style=\"width: 2138px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/09\/20250924200129-68d3dd997656d.jpg\" alt=\"\u56fe5\uff1a\u5916\u6ccc\u4f53\u7684\u751f\u7269\u5408\u6210\u548c\u5206\u5b50\u7ec4\u6210\u3002\" width=\"2128\" height=\"1503\" title=\"\"><p class=\"wp-caption-text\">\u56fe5\uff1a\u5916\u6ccc\u4f53\u7684\u751f\u7269\u5408\u6210\u548c\u5206\u5b50\u7ec4\u6210\u3002<\/p><\/div><figcaption><\/figcaption><\/figure>\n<h2><span class=\"ez-toc-section\" id=\"%E5%B9%B2%E7%BB%86%E8%83%9E%E5%A4%96%E6%B3%8C%E4%BD%93%E5%9C%A8%E6%B2%BB%E7%96%97%E7%A5%9E%E7%BB%8F%E9%80%80%E8%A1%8C%E6%80%A7%E7%96%BE%E7%97%85%E4%B8%AD%E7%9A%84%E6%BD%9C%E5%8A%9B\"><\/span><strong>\u5e72\u7ec6\u80de\u5916\u6ccc\u4f53\u5728\u6cbb\u7597\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u4e2d\u7684\u6f5c\u529b<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>\u5916\u6ccc\u4f53\u5728\u795e\u7ecf\u6027\u75f4\u5446\uff08ND\uff09\u4e2d\u7684\u6cbb\u7597\u6f5c\u529b\u6e90\u4e8e\u5176\u80fd\u591f\u4f20\u9012\u795e\u7ecf\u4fdd\u62a4\u548c\u518d\u751f\u4fe1\u53f7\u3001\u7a7f\u8fc7\u8840\u8111\u5c4f\u969c (BBB) \u5e76\u6700\u5927\u9650\u5ea6\u964d\u4f4e\u5e72\u7ec6\u80de\u6cbb\u7597\u76f8\u5173\u98ce\u9669\u3002\u4e34\u5e8a\u524d\u7814\u7a76\u8868\u660e\uff0c\u5916\u6ccc\u4f53\u80fd\u591f\u5728\u52a8\u7269\u6a21\u578b\u4e2d\u4f20\u9012\u795e\u7ecf\u4fdd\u62a4\u836f\u7269\u3001\u51cf\u8f7b\u795e\u7ecf\u708e\u75c7\u5e76\u4fc3\u8fdb\u795e\u7ecf\u5143\u518d\u751f\uff0c\u8fd9\u51f8\u663e\u4e86\u5176\u836f\u7528\u6f5c\u529b\u3002<\/p>\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E5%B9%B2%E7%BB%86%E8%83%9E%E5%A4%96%E6%B3%8C%E4%BD%93%E6%B2%BB%E7%96%97%E9%98%BF%E5%B0%94%E8%8C%A8%E6%B5%B7%E9%BB%98%E7%97%85\"><\/span><strong>\u5e72\u7ec6\u80de\u5916\u6ccc\u4f53\u6cbb\u7597\u963f\u5c14\u8328\u6d77\u9ed8\u75c5<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>MSC\u884d\u751f\u7684\u5916\u6ccc\u4f53\u5177\u5907\u6297\u708e\u3001\u795e\u7ecf\u4fdd\u62a4\u548c\u4fc3\u8fdb\u518d\u751f\u80fd\u529b\uff0c\u80fd\u7f13\u89e3\u795e\u7ecf\u708e\u75c7\u3001\u4fc3\u8fdb\u795e\u7ecf\u91cd\u5851\u548c\u8840\u7ba1\u751f\u6210\uff0c\u5728\u52a8\u7269\u6a21\u578b\u4e2d\u51cf\u5c11\u708e\u75c7\u3001\u6539\u5584\u8bb0\u5fc6\u3002<\/p>\n<p><strong>NSC\u5916\u6ccc\u4f53\u540c\u6837\u53ef\u4fc3\u8fdb\u795e\u7ecf\u5143\u5b58\u6d3b\u3001\u523a\u6fc0\u795e\u7ecf\u53d1\u751f\uff0c\u5e76\u964d\u4f4e\u78f7\u9178\u5316tau\u548c\u03b2-\u6dc0\u7c89\u6837\u86cb\u767d\u6c34\u5e73<\/strong>\u3002\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u548c\u5c0f\u80f6\u8d28\u7ec6\u80de\u6765\u6e90\u7684\u5916\u6ccc\u4f53\u4e5f\u663e\u793a\u6cbb\u7597\u6f5c\u529b\uff0c\u5982\u8c03\u8282\u7a81\u89e6\u6d3b\u52a8\u3001\u8c03\u63a7\u708e\u75c7\u53cd\u5e94\uff08\u5982\u4fc3\u8fdbM2\u6781\u5316\uff09\u7b49\u3002\u6b64\u5916\uff0c\u542b\u9798\u7cd6\u8102\u7684\u5916\u6ccc\u4f53\u80fd\u51cf\u8f7b\u6dc0\u7c89\u6837\u75c5\u7406\uff0c\u53ef\u80fd\u5145\u5f53\u6e05\u9664A\u03b2\u7684\u201c\u4fe1\u4f7f\u201d\u3002<\/p>\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E5%B9%B2%E7%BB%86%E8%83%9E%E5%A4%96%E6%B3%8C%E4%BD%93%E6%B2%BB%E7%96%97%E5%B8%95%E9%87%91%E6%A3%AE%E7%97%85\"><\/span><strong>\u5e72\u7ec6\u80de\u5916\u6ccc\u4f53\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u5916\u6ccc\u4f53\u5728\u5e15\u91d1\u68ee\u75c5\uff08PD\uff09\u4e2d\u7684\u6cbb\u7597\u6f5c\u529b\u5df2\u5728\u4e34\u5e8a\u524d\u7814\u7a76\u4e2d\u5f97\u5230\u5e7f\u6cdb\u63a2\u7a76\uff0c\u63ed\u793a\u4e86\u4f53\u5916\u548c\u4f53\u5185\u6a21\u578b\u4e2d\u795e\u7ecf\u4fdd\u62a4\u7684\u591a\u79cd\u673a\u5236\u548c\u91cd\u5927\u524d\u666f\u3002\u8fd9\u4e9b\u6a21\u578b\u51f8\u663e\u4e86MSC\u548cNSC\u884d\u751f\u7684\u5916\u6ccc\u4f53\u5728\u51cf\u8f7bPD\u75c5\u7406\u7279\u5f81\u65b9\u9762\u7684\u529f\u6548\u3002<\/p>\n<p><strong>\u5bcc\u542b\u795e\u7ecf\u8425\u517b\u548c\u6297\u708e\u56e0\u5b50\u7684MSC\u884d\u751f\u5916\u6ccc\u4f53\u5df2\u88ab\u8bc1\u5b9e\u80fd\u591f\u51cf\u5c11\u03b1-\u7a81\u89e6\u6838\u86cb\u767d\uff08\u03b1\u2010syn\uff09\u805a\u96c6\u3001\u4fc3\u8fdb\u81ea\u566c\u3001\u589e\u5f3a\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u5b58\u6d3b\u5e76\u6539\u5584\u8fd0\u52a8\u969c\u788d<\/strong>\u3002\u4f8b\u5982\uff0c\u5b83\u4eec\u901a\u8fc7\u4fc3\u8fdb\u8111\u5fae\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\u7684\u8840\u7ba1\u751f\u6210\u6539\u5584\u795e\u7ecf\u8840\u7ba1\u529f\u80fd\uff0c\u6291\u5236\u5c0f\u80f6\u8d28\u7ec6\u80de\u6d3b\u5316\u5e76\u51cf\u5c11\u795e\u7ecf\u708e\u75c7\u3002<\/p>\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E5%B9%B2%E7%BB%86%E8%83%9E%E5%A4%96%E6%B3%8C%E4%BD%93%E6%B2%BB%E7%96%97%E8%90%8E%E7%BC%A9%E4%BE%A7%E7%B4%A2%E7%A1%AC%E5%8C%96%E7%97%87\"><\/span><strong>\u5e72\u7ec6\u80de\u5916\u6ccc\u4f53\u6cbb\u7597\u840e\u7f29\u4fa7\u7d22\u786c\u5316\u75c7<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u5e72\u7ec6\u80de\u5916\u6ccc\u4f53\u5728\u808c\u840e\u7f29\u4fa7\u7d22\u786c\u5316\u75c7\uff08ALS\uff09\u4e2d\u5c55\u73b0\u51fa\u591a\u91cd\u4fdd\u62a4\u4f5c\u7528\u3002\u8102\u80aa\u6765\u6e90\u5e72\u7ec6\u80de\uff08AD-SCs\uff09\u5916\u6ccc\u4f53\u80fd\u591f\u51cf\u7f13SOD1\u86cb\u767d\u805a\u96c6\u3001\u6539\u5584\u7ebf\u7c92\u4f53\u529f\u80fd\uff0c\u5e76\u5728\u6c27\u5316\u5e94\u6fc0\u73af\u5883\u4e0b\u964d\u4f4e\u7ec6\u80de\u635f\u4f24\u3001\u63d0\u5347\u7ec6\u80de\u5b58\u6d3b\u7387\u3002\u5728ALS\u52a8\u7269\u6a21\u578b\u4e2d\uff0c\u65e0\u8bba\u662f\u9759\u8109\u6ce8\u5c04\u8fd8\u662f\u9f3b\u8154\u7ed9\u836f\uff0c\u8fd9\u4e9b\u5916\u6ccc\u4f53\u90fd\u80fd\u8de8\u8d8a\u8840\u8111\u5c4f\u969c\u5e76\u7cbe\u51c6\u5b9a\u4f4d\u53d7\u7d2f\u8111\u533a\uff0c\u4ece\u800c\u6539\u5584\u5c0f\u9f20\u7684\u8fd0\u52a8\u529f\u80fd\uff0c\u663e\u793a\u51fa\u826f\u597d\u7684\u795e\u7ecf\u4fdd\u62a4\u6548\u679c\u548c\u5929\u7136\u9776\u5411\u6027\u3002<\/p>\n<p>\u6b64\u5916\uff0c\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSC\uff09\u5916\u6ccc\u4f53\u540c\u6837\u5728ALS\u4e2d\u5177\u6709\u6cbb\u7597\u6f5c\u529b\u3002\u5b83\u4eec\u53ef\u4fc3\u8fdb\u8fd0\u52a8\u795e\u7ecf\u5143\u7684\u795e\u7ecf\u7a81\u8d77\u751f\u957f\u548c\u5f62\u6001\u6539\u5584\uff0c\u5e76\u643a\u5e26\u591a\u79cd\u6297\u6c27\u5316\u548c\u6297\u708e\u57fa\u56e0\uff0c\u4ece\u800c\u5728\u6b63\u5e38\u548c\u5e94\u6fc0\u6761\u4ef6\u4e0b\u5747\u80fd\u589e\u5f3a\u795e\u7ecf\u5143\u7684\u5b58\u6d3b\u4e0e\u529f\u80fd\u3002\u8fd9\u4e9b\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0c<strong>\u5e72\u7ec6\u80de\u5916\u6ccc\u4f53\u901a\u8fc7\u8c03\u63a7\u708e\u75c7\u53cd\u5e94\u3001\u7f13\u89e3\u6c27\u5316\u5e94\u6fc0\u548c\u6539\u5584\u7ec6\u80de\u80fd\u91cf\u4ee3\u8c22<\/strong>\uff0c\u4e3aALS\u7684\u65b0\u578b\u6cbb\u7597\u7b56\u7565\u63d0\u4f9b\u4e86\u575a\u5b9e\u7684\u7406\u8bba\u4e0e\u5b9e\u9a8c\u57fa\u7840\u3002<\/p>\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E5%B9%B2%E7%BB%86%E8%83%9E%E5%A4%96%E6%B3%8C%E4%BD%93%E6%B2%BB%E7%96%97%E4%BA%A8%E5%BB%B7%E9%A1%BF%E8%88%9E%E8%B9%88%E7%97%87\"><\/span><strong>\u5e72\u7ec6\u80de\u5916\u6ccc\u4f53\u6cbb\u7597\u4ea8\u5ef7\u987f\u821e\u8e48\u75c7<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u5e72\u7ec6\u80de\u5916\u6ccc\u4f53\u4e3a\u6cbb\u7597\u4ea8\u5ef7\u987f\u821e\u8e48\u75c7\uff08HD\uff09\u63d0\u4f9b\u4e86\u4e00\u79cd\u6781\u5177\u524d\u666f\u7684\u65e0\u7ec6\u80de\u6cbb\u7597\u7b56\u7565\u3002\u5176\u6838\u5fc3\u4f5c\u7528\u5728\u4e8e\u4f5c\u4e3a\u5929\u7136\u7684\u7eb3\u7c73\u7ea7\u8f7d\u4f53\uff0c\u80fd\u591f\u6709\u6548\u7a7f\u8d8a\u8840\u8111\u5c4f\u969c\uff0c\u5c06\u5177\u6709\u6cbb\u7597\u4ef7\u503c\u7684\u751f\u7269\u6d3b\u6027\u5206\u5b50\uff08\u5982\u5c0f\u5e72\u6270RNA\u548c\u5fae\u5c0fRNA\uff09\u7cbe\u51c6\u9012\u9001\u81f3\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u7684\u53d7\u635f\u8111\u533a\u3002\u5728HD\u4e2d\uff0c\u8fd9\u65e8\u5728\u964d\u4f4e\u7a81\u53d8\u4ea8\u5ef7\u987f\u86cb\u767d\uff08mHTT\uff09\u7684\u6bd2\u6027\u805a\u96c6\u3001\u4fc3\u8fdb\u795e\u7ecf\u8425\u517b\u56e0\u5b50\uff08\u5982BDNF\uff09\u7684\u751f\u6210\uff0c\u5e76\u6700\u7ec8\u53d1\u6325\u795e\u7ecf\u4fdd\u62a4\u4f5c\u7528\uff0c\u5ef6\u7f13\u75be\u75c5\u8fdb\u5c55\u3002<\/p>\n<p>\u5176\u6cbb\u7597\u673a\u5236\u4e3b\u8981\u901a\u8fc7\u6240\u643a\u5e26\u7684\u8d27\u7269\u5206\u5b50\u6765\u5b9e\u73b0\u3002\u4f8b\u5982\uff0c\u8d1f\u8f7dsiRNA\u7684\u5916\u6ccc\u4f53\u53ef\u4ee5\u7279\u5f02\u6027\u6c89\u9ed8\u7a81\u53d8\u578bHTT\u57fa\u56e0\u7684\u8868\u8fbe\uff0c\u4ece\u6e90\u5934\u4e0a\u51cf\u5c11\u6bd2\u6027\u86cb\u767d\u7684\u4ea7\u751f\u3002\u540c\u65f6\uff0c\u5916\u6ccc\u4f53\u5bcc\u542b\u7684\u7279\u5b9amiRNA\uff08\u5982miR-124\uff09\u80fd\u591f\u901a\u8fc7\u6291\u5236REST\u7b49\u5173\u952e\u9776\u70b9\uff0c\u91cd\u5efa\u53d7\u635f\u7684\u57fa\u56e0\u8c03\u63a7\u7f51\u7edc\uff0c\u4fc3\u8fdb\u795e\u7ecf\u5143\u5b58\u6d3b\u548c\u529f\u80fd\u6062\u590d\u3002\u6b64\u5916\uff0c<strong>\u6e90\u81ea\u5e72\u7ec6\u80de\uff08\u5982\u8102\u80aa\u6765\u6e90\u5e72\u7ec6\u80de\uff09\u7684\u5916\u6ccc\u4f53\u672c\u8eab\u8fd8\u5177\u6709\u5929\u7136\u7684\u795e\u7ecf\u4fdd\u62a4\u7279\u6027\uff0c\u80fd\u591f\u51cf\u8f7b\u795e\u7ecf\u708e\u75c7\u3001\u6539\u5584\u7ec6\u80de\u5e94\u6fc0\u53cd\u5e94<\/strong>\uff0c\u4ece\u800c\u4e3a\u53d7\u635f\u795e\u7ecf\u5143\u63d0\u4f9b\u4e00\u4e2a\u66f4\u6709\u5229\u7684\u5fae\u73af\u5883\u3002<\/p>\n<p>\u76ee\u524d\uff0c\u5173\u4e8e\u4f7f\u7528\u6e90\u81ea\u5e72\u7ec6\u80de\uff08\u4f8b\u5982MSC\u3001NSC\u6216iPSC\uff09\u7684\u5916\u6ccc\u4f53\u8fdb\u884c\u4ea8\u5ef7\u987f\u6c0f\u75c5\u6cbb\u7597\u7684\u6587\u732e\u975e\u5e38\u6709\u9650\u3002\u867d\u7136\u5e72\u7ec6\u80de\u884d\u751f\u7684\u5916\u6ccc\u4f53\u56e0\u5176\u795e\u7ecf\u4fdd\u62a4\u7279\u6027\u800c\u663e\u793a\u51fa\u5728\u5404\u79cd\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u4e2d\u7684\u6cbb\u7597\u6f5c\u529b\uff0c\u4f46\u8bc1\u660e\u5176\u5728\u4ea8\u5ef7\u987f\u6c0f\u75c5\u6a21\u578b\u4e2d\u7597\u6548\u7684\u5177\u4f53\u4e34\u5e8a\u524d\u7814\u7a76\u5374\u5f88\u5c11\u3002<\/p>\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E5%B9%B2%E7%BB%86%E8%83%9E%E6%9D%A5%E6%BA%90%E7%9A%84%E5%A4%96%E6%B3%8C%E4%BD%93%E5%9C%A8ND%E4%B8%AD%E7%9A%84%E4%B8%B4%E5%BA%8A%E8%AF%95%E9%AA%8C\"><\/span><strong>\u5e72\u7ec6\u80de\u6765\u6e90\u7684\u5916\u6ccc\u4f53\u5728ND\u4e2d\u7684\u4e34\u5e8a\u8bd5\u9a8c<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u4eba\u4eec\u666e\u904d\u8ba4\u4e3a\uff0c\u5916\u6ccc\u4f53\u662f\u6cbb\u7597\u591a\u79cd\u75be\u75c5\u7684\u4e00\u79cd\u5f88\u6709\u524d\u666f\u7684\u9009\u62e9\u3002\u5927\u91cf\u4e34\u5e8a\u524d\u7814\u7a76\u8868\u660e\uff0c\u5916\u6ccc\u4f53\u53ef\u6cbb\u7597\u591a\u79cd\u75be\u75c5\u3002\u6700\u8fd1\uff0c\u5916\u6ccc\u4f53\u5df2\u88ab\u7528\u4e8e\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u7279\u522b\u662f\u4ece\u4eba\u7c7b\u5e72\u7ec6\u80de\u4e2d\u83b7\u5f97\u7684\u5916\u6ccc\u4f53\u3002\u6b64\u5916\uff0c\u5916\u6ccc\u4f53\u5728\u4e34\u5e8a\u5e94\u7528\u4e2d\u7684\u4e3b\u8981\u7528\u9014\u5305\u62ec\u4f5c\u4e3a\u751f\u7269\u6807\u8bb0\u7269\u3001\u63d0\u4f9b\u57fa\u4e8e\u5916\u6ccc\u4f53\u7684\u7597\u6cd5\u548c\u8f85\u52a9\u836f\u7269\u8f93\u9001\u7cfb\u7edf\u3002\u76ee\u524d\uff0c\u7814\u7a76\u5916\u6ccc\u4f53\u5728NDs\u4e2d\u5e94\u7528\u7684\u4e34\u5e8a\u8bd5\u9a8c\u4ecd\u7136\u5f88\u5c11\uff0c\u8fd9\u53cd\u6620\u4e86\u8fd9\u4e00\u9886\u57df\u7684\u65b0\u9896\u6027\u3002<\/p>\n<p>\u4e00\u9879\u6b63\u5728\u62db\u52df\u7684\u4e34\u5e8a\u8bd5\u9a8c\u5df2\u5b8c\u6210\u2160\u671f\uff0c\u65e8\u5728\u8bc4\u4f30\u4ece\u4eba\u8110\u5e26\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08UC-MSC\uff09\u5206\u79bb\u7684\u5916\u6ccc\u4f53\u9f3b\u7528\u6ef4\u5242\u5728ALS\u6cbb\u7597\u4e2d\u7684\u5b89\u5168\u6027\u548c\u521d\u6b65\u7597\u6548\uff0c\u5e76\u5c06\u5728\u2161\u671f\u9636\u6bb5\u8fdb\u4e00\u6b65\u5f00\u5c55\u8bc4\u4f30\uff08ClinicalTrials.gov\u7f16\u53f7\uff1aNCT06598202\uff09\u3002<\/p>\n<p>\u53e6\u4e00\u9879\u5c1a\u672a\u5f00\u59cb\u62db\u52df\u7684\u65b0\u7814\u7a76\u8ba1\u5212\u63a2\u8ba8\u5c06\u6709\u6c27\u8fd0\u52a8\u4e0e\u8ba4\u77e5\u8bad\u7ec3\u76f8\u7ed3\u5408\u7684\u957f\u671f\u5e72\u9884\u9879\u76ee\u5bf9\u9ad8\u98ce\u9669AD\u60a3\u8005\u8ba4\u77e5\u80fd\u529b\u53ca\u8840\u6db2\u4e2d\u795e\u7ecf\u5916\u6ccc\u4f53\u7a81\u89e6\u86cb\u767d\u7b49\u751f\u7269\u6807\u5fd7\u7269\u7684\u5f71\u54cd\u3002\u901a\u8fc7\u5206\u6790\u8840\u6db2\u5faa\u73af\u5916\u6ccc\u4f53\u4e2d\u7684GAP43\u3001\u795e\u7ecf\u9897\u7c92\u86cb\u767d\u3001SNAP25\u548c\u7a81\u89e6\u56ca\u6ce1\u86cb\u767d\u7b49\u6807\u5fd7\u7269\uff0c\u7814\u7a76\u4eba\u5458\u53ef\u4ee5\u5728\u4e34\u5e8a\u75c7\u72b6\u51fa\u73b0\u4e4b\u524d\u8bc6\u522bAD\u7684\u65e9\u671f\u8ff9\u8c61\uff08ClinicalTrials.gov\u7f16\u53f7\uff1aNCT05163626\uff09\u3002<\/p>\n<p>\u6b64\u5916\uff0c\u8fd8\u6709\u4e00\u9879\u4e34\u5e8a\u8bd5\u9a8c\u8bc4\u4f30\u4e86AD-MSC\u5916\u6ccc\u4f53\u6cbb\u7597AD\u7684\u5b89\u5168\u6027\u548c\u7597\u6548\uff0c\u8be5\u8bd5\u9a8c\u901a\u8fc7\u9f3b\u8154\u7ed9\u836f\u65b9\u5f0f\u8fdb\u884c\uff0c\u7ed3\u679c\u663e\u793a\u60a3\u8005\u8ba4\u77e5\u529f\u80fd\u5f97\u5230\u6539\u5584\uff08ClinicalTrials.gov\u7f16\u53f7\uff1aNCT04388982\uff09\u3002<\/p>\n<p>\u7531\u4e8e\u90e8\u5206\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\uff08ND\uff09\u5c1a\u65e0\u5916\u6ccc\u4f53\u7597\u6cd5\uff0c\u7814\u7a76\u4eba\u5458\u4e5f\u63a2\u7d22\u4e86\u5916\u6ccc\u4f53\u5728\u8bca\u65ad\u4e2d\u7684\u6f5c\u529b\u3002\u4f8b\u5982\uff0c\u4e00\u9879\u89c2\u5bdf\u6027\u7814\u7a76\u901a\u8fc7\u5206\u6790\u8840\u6db2\u6210\u5206\uff08\u5305\u62ec\u5916\u6ccc\u4f53\u53ca\u5176\u76f8\u5173\u751f\u7269\u6807\u5fd7\u7269\uff09\u6765\u7814\u7a76\u795e\u7ecf\u8ba4\u77e5\u969c\u788d\u7684\u5f71\u54cd\u56e0\u7d20\uff0c\u7279\u522b\u662fAD\uff08ClinicalTrials.gov\u7f16\u53f7\uff1aNCT03275363\uff09\u3002\u53e6\u4e00\u9879\u7814\u7a76\u5219\u901a\u8fc7\u5206\u6790\u5c3f\u6db2\u5916\u6ccc\u4f53\u5bfb\u627e\u5e15\u91d1\u68ee\u75c5\uff08PD\uff09\u7684\u6f5c\u5728\u751f\u7269\u6807\u5fd7\u7269\uff0c\u7ed3\u679c\u53d1\u73b0\u5bcc\u542b\u4eae\u6c28\u9178\u91cd\u590d\u6fc0\u91762\uff08LRRK2\uff09\u53ca\u5176\u4ed6\u86cb\u767d\u8d28\u4e0ePD\u7684\u75c5\u7406\u751f\u7406\u76f8\u5173\uff08ClinicalTrials.gov\u7f16\u53f7\uff1aNCT01860118\uff09\u3002<\/p>\n<p>\u76ee\u524d\uff0c\u867d\u7136\u5df2\u6709\u5c11\u6570\u4e34\u5e8a\u8bd5\u9a8c\u5728\u63a2\u7d22\u5916\u6ccc\u4f53\u6cbb\u7597AD\u548cALS\uff0c\u4f46\u9488\u5bf9PD\u548cHD\u7684\u4e34\u5e8a\u8bd5\u9a8c\u5c1a\u672a\u5f00\u5c55\uff08\u88681\uff09\u3002<\/p>\n<figure class=\"wp-block-image size-full\">\n<p><div style=\"width: 782px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/09\/20250924200130-68d3dd9a53cb2.png\" alt=\"\u88681\uff1a\u5e72\u7ec6\u80de\u5916\u6ccc\u4f53\u6cbb\u7597\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u7684\u4e34\u5e8a\u8bd5\u9a8c\" width=\"772\" height=\"191\" title=\"\"><p class=\"wp-caption-text\">\u88681\uff1a\u5e72\u7ec6\u80de\u5916\u6ccc\u4f53\u6cbb\u7597\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u7684\u4e34\u5e8a\u8bd5\u9a8c<\/p><\/div><figcaption><\/figcaption><\/figure>\n<p>\u4f5c\u4e3a\u4e00\u79cd\u65b0\u9896\u4e14\u6709\u524d\u666f\u7684\u6cbb\u7597\u65b9\u5f0f\uff0c\u5916\u6ccc\u4f53\u7597\u6cd5\u4ecd\u9700\u8fdb\u4e00\u6b65\u7814\u7a76\u548c\u4e34\u5e8a\u9a8c\u8bc1\uff0c\u4ee5\u8bc4\u4f30\u5176\u5728\u5e94\u5bf9\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u590d\u6742\u6027\u4e2d\u7684\u6f5c\u529b\u3002\u5728\u65e9\u671f\u5f00\u53d1\u9636\u6bb5\uff0c\u5916\u6ccc\u4f53\u7597\u6cd5\u663e\u793a\u51fa\u901a\u8fc7\u63d0\u4f9b\u6bd4\u5e72\u7ec6\u80de\u5e72\u9884\u66f4\u5b89\u5168\u3001\u66f4\u6709\u6548\u3001\u66f4\u6613\u83b7\u53d6\u7684\u6cbb\u7597\u65b9\u6848\uff0c\u663e\u8457\u63d0\u5347ND\u6cbb\u7597\u7684\u6f5c\u529b\u3002<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%E7%BB%93%E8%AE%BA%E4%B8%8E%E6%9C%AA%E6%9D%A5%E5%B1%95%E6%9C%9B\"><\/span><strong>\u7ed3\u8bba\u4e0e\u672a\u6765\u5c55\u671b<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>\u672c\u7efc\u8ff0\u91cd\u70b9\u4ecb\u7ecd\u4e86\u5e72\u7ec6\u80de\u6cbb\u7597\u795e\u7ecf\u6027\u75f4\u5446\uff08ND\uff09\uff0c\u5305\u62ec\u963f\u5c14\u8328\u6d77\u9ed8\u75c7\uff08AD\uff09\u3001\u5e15\u91d1\u68ee\u75c5\uff08PD\uff09\u3001\u808c\u840e\u7f29\u6027\u810a\u9ad3\u4fa7\u7d22\u786c\u5316\u75c7\uff08ALS\uff09\u548c\u4ea8\u5ef7\u987f\u6c0f\u75c5\uff08HD\uff09\u7684\u8fdb\u5c55\u3002\u5c3d\u7ba1\u53d6\u5f97\u4e86\u663e\u8457\u8fdb\u5c55\uff0c\u5c24\u5176\u662f\u5728\u65e9\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u3002<\/p>\n<p>\u57fa\u4e8e\u5e72\u7ec6\u80de\u5916\u6ccc\u4f53\u53ef\u7f13\u89e3\u795e\u7ecf\u708e\u75c7\u3001\u51cf\u5c11\u6c27\u5316\u5e94\u6fc0\u3001\u4fc3\u8fdb\u795e\u7ecf\u5143\u518d\u751f\uff0c\u5e76\u901a\u8fc7\u5de5\u7a0b\u5316\u624b\u6bb5\u63d0\u9ad8\u9776\u5411\u6027\u3002\u5c3d\u7ba1\u4e34\u5e8a\u7814\u7a76\u4ecd\u5904\u4e8e\u521d\u6b65\u9636\u6bb5\uff0c\u4e14\u9488\u5bf9PD\u4e0eHD\u7684\u8bd5\u9a8c\u6709\u9650\uff0c\u4f46\u968f\u7740\u6280\u672f\u8fdb\u6b65\u548c\u751f\u4ea7\u6807\u51c6\u5316\uff0c\u672a\u6765\u6709\u671b\u63d0\u4f9b\u66f4\u5b89\u5168\u3001\u9ad8\u6548\u3001\u4fb5\u5165\u6027\u66f4\u4f4e\u7684\u6cbb\u7597\u65b9\u6848\uff0c\u6539\u5584ND\u60a3\u8005\u9884\u540e\u3002\u672a\u6765\u7684\u4e3e\u63aa\u5e94\u4fa7\u91cd\u4e8e\u6269\u5927\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u4ee5\u6db5\u76d6\u66f4\u591aND\uff0c\u4f8b\u5982\u5e15\u91d1\u68ee\u75c5\uff08PD\uff09\u548c\u4ea8\u5ef7\u987f\u6c0f\u75c5\uff08HD\uff09\uff0c\u540c\u65f6\u89e3\u51b3\u5916\u6ccc\u4f53\u751f\u4ea7\u7684\u53ef\u6269\u5c55\u6027\u548c\u6807\u51c6\u5316\u95ee\u9898\u3002\u4eba\u4eec\u5bf9\u5916\u6ccc\u4f53\u7597\u6cd5\u65e5\u76ca\u589e\u957f\u7684\u5174\u8da3\uff0c\u4ee5\u53ca\u6280\u672f\u8fdb\u6b65\u548c\u5bf9\u5176\u6cbb\u7597\u6f5c\u529b\u7684\u6df1\u5165\u7406\u89e3\uff0c\u9884\u8ba1\u5c06\u63a8\u52a8ND\u6cbb\u7597\u6280\u672f\u7684\u9769\u547d\u6027\u53d1\u5c55\u3002\u8fd9\u4e9b\u8fdb\u6b65\u53ef\u80fd\u6709\u52a9\u4e8e\u66f4\u7cbe\u51c6\u3001\u66f4\u9ad8\u6548\u3001\u4fb5\u5165\u6027\u66f4\u4f4e\u7684\u6cbb\u7597\u65b9\u6848\uff0c\u4ece\u800c\u6539\u5584\u8fd9\u4e9bND\u60a3\u8005\u7684\u9884\u540e\u3002<\/p>\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\"><p>References:<\/p>\n<p>[1]:Isik S, Osman S, Yeman-Kiyak B, Shamshir SRM, Sanchez NME. Advances in Neurodegenerative Disease Therapy: Stem Cell Clinical Trials and Promise of Engineered Exosomes. CNS Neurosci Ther. 2025 Sep;31(9):e70577. doi: 10.1111\/cns.70577. PMID: 40904199; PMCID: PMC12409071.<\/p><\/blockquote>\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\"><p>Disclaimer: This article is intended only to disseminate scientific knowledge and share industry perspectives, and does not constitute any clinical diagnostic advice! The information published by Hangi Stem Cells is not a substitute for the professional advice of a physician or pharmacist. If you have any questions about copyright or other issues, please feel free to contact me.<\/p><\/blockquote>","protected":false},"excerpt":{"rendered":"<p>\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u6cbb\u7597\u4e00\u76f4\u662f\u96be\u9898\uff0c\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u3001\u5e15\u91d1\u68ee\u75c5\u3001ALS\u7b49\u60a3\u8005\u4f20\u7edf\u7597\u6cd5\u591a\u53ea\u80fd\u7f13\u89e3\u75c7\u72b6\u3002\u5e72\u7ec6\u80de\u53ef\u4ee5\u4fee\u590d\u53d7\u635f\u795e\u7ecf\uff0c\u800c\u5e72\u7ec6\u80de\u5916\u6ccc\u4f53\u50cf\u5929\u7136\u4fe1\u4f7f\uff0c\u80fd\u7a7f\u8fc7\u8840\u8111\u5c4f\u969c\uff0c\u628a\u795e\u7ecf\u4fdd\u62a4\u548c\u518d\u751f\u4fe1\u53f7\u76f4\u63a5\u9001\u5230\u8111\u5185\u3002\u7814\u7a76\u663e\u793a\uff0cMSC\u548cNSC\u6765\u6e90\u7684\u5916\u6ccc\u4f53\u53ef\u51cf\u8f7b\u708e\u75c7\u3001\u4fdd\u62a4\u795e\u7ecf\u5143\u3001\u4fc3\u8fdb\u795e\u7ecf\u518d\u751f\u3002\u5e72\u7ec6\u80de\u4e0e\u5916\u6ccc\u4f53\u7ed3\u5408\uff0c\u4e3a\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u6cbb\u7597\u63d0\u4f9b\u4e86\u4f4e\u4fb5\u5165\u3001\u9ad8\u5b89\u5168\u6027\u7684\u65b0\u65b9\u5411\uff0c\u6709\u671b\u771f\u6b63\u6539\u5584\u60a3\u8005\u751f\u6d3b\u8d28\u91cf\u3002<\/p>","protected":false},"author":1,"featured_media":19188,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"image","meta":{"footnotes":""},"categories":[76],"tags":[150,169,168],"_links":{"self":[{"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/posts\/19196"}],"collection":[{"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/comments?post=19196"}],"version-history":[{"count":3,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/posts\/19196\/revisions"}],"predecessor-version":[{"id":19435,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/posts\/19196\/revisions\/19435"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/media\/19188"}],"wp:attachment":[{"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/media?parent=19196"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/categories?post=19196"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/tags?post=19196"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}