{"id":19266,"date":"2025-09-25T04:17:44","date_gmt":"2025-09-24T12:17:44","guid":{"rendered":"https:\/\/www.hjtdsm.cn\/stem-cells\/nsc\/19266.html"},"modified":"2025-10-09T17:38:21","modified_gmt":"2025-10-09T09:38:21","slug":"%e4%bb%8e%e9%9d%99%e6%81%af%e5%88%b0%e6%bf%80%e6%b4%bb%ef%bc%9a%e9%9d%b6%e5%90%91%e8%84%91%e5%ae%a4%e4%b8%8b%e5%8c%ba%e7%9a%84%e7%a5%9e%e7%bb%8f%e5%b9%b2%e7%bb%86%e8%83%9e%e5%ae%9e%e7%8e%b0%e5%b8%95","status":"publish","type":"post","link":"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/nsc\/19266.html","title":{"rendered":"From resting to activation: back infusion of stem cells prompts neural regeneration in situ in Parkinson's disease by targeting neural stem cells in the subventricular zone"},"content":{"rendered":"<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\"><p>\u5e15\u91d1\u68ee\u75c5\u662f\u4e00\u79cd\u7531\u9ed1\u8d28\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u9000\u5316\u5f15\u8d77\u7684\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u3002\u76ee\u524d\u5c1a\u65e0\u6cbb\u6108\u65b9\u6cd5\uff0c\u56e0\u6b64\u8feb\u5207\u9700\u8981\u65b0\u7684\u6cbb\u7597\u65b9\u6cd5\u3002\u4e00\u79cd\u6b63\u5728\u7814\u7a76\u7684\u6f5c\u5728\u7b56\u7565\u662f\u57fa\u4e8e\u5e72\u7ec6\u80de\u7684\u65b9\u6cd5\u6765\u66ff\u6362\u4e22\u5931\u7684\u795e\u7ecf\u5143\uff0c\u4f8b\u5982\u5229\u7528\u5185\u6e90\u6027\u795e\u7ecf\u5e72\u7ec6\u80de (NSC)\u3002\u8fd9\u4e9b\u7ec6\u80de\u4f4d\u4e8e\u4e0e\u4fa7\u8111\u5ba4\u5bf9\u9f50\u7684\u8111\u5ba4\u4e0b\u533a (SVZ)\uff0c\u5728\u8001\u5e74\u548c\u60a3\u75c5\u7684\u54fa\u4e73\u52a8\u7269\u5927\u8111\u4e2d\u5904\u4e8e\u4f11\u7720\u72b6\u6001\u3002\u7136\u800c\uff0c\u5728\u9002\u5f53\u7684\u523a\u6fc0\u4e0b\uff0cNSC\u53ef\u4ee5\u8f6c\u53d8\u4e3a\u6d3b\u5316\u72b6\u6001\uff0c\u589e\u6b96\u548c\u5206\u5316\u3002<\/p><\/blockquote>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_79_2 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewbox=\"0 0 24 24\" version=\"1.2\" baseprofile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1' ><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/nsc\/19266.html\/#%E4%BB%8E%E9%9D%99%E6%81%AF%E5%88%B0%E6%BF%80%E6%B4%BB%EF%BC%9A%E5%9B%9E%E8%BE%93%E5%B9%B2%E7%BB%86%E8%83%9E%E4%BF%83%E4%BD%BF%E9%9D%B6%E5%90%91%E8%84%91%E5%AE%A4%E4%B8%8B%E5%8C%BA%E7%9A%84%E7%A5%9E%E7%BB%8F%E5%B9%B2%E7%BB%86%E8%83%9E%E5%AE%9E%E7%8E%B0%E5%B8%95%E9%87%91%E6%A3%AE%E7%97%85%E5%8E%9F%E4%BD%8D%E7%A5%9E%E7%BB%8F%E5%86%8D%E7%94%9F\" >From resting to activation: back infusion of stem cells prompts neural regeneration in situ in Parkinson's disease by targeting neural stem cells in the subventricular zone<\/a><ul class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/nsc\/19266.html\/#%E5%B8%95%E9%87%91%E6%A3%AE%E7%97%85%EF%BC%9A%E6%B5%81%E8%A1%8C%E7%97%85%E5%AD%A6%E3%80%81%E7%97%85%E7%90%86%E6%9C%BA%E5%88%B6%E4%B8%8E%E6%B2%BB%E7%96%97%E6%8C%91%E6%88%98%E7%9A%84%E4%B8%89%E9%87%8D%E7%BB%B4%E5%BA%A6\" 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href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/nsc\/19266.html\/#1%E3%80%81%E7%94%9F%E9%95%BF%E5%9B%A0%E5%AD%90%E4%BF%83%E8%BF%9B%E7%A5%9E%E7%BB%8F%E5%B9%B2%E7%BB%86%E8%83%9E%E8%87%AA%E6%88%91%E6%9B%B4%E6%96%B0%E6%88%96%E5%88%86%E5%8C%96\" >1\u3001\u751f\u957f\u56e0\u5b50\u4fc3\u8fdb\u795e\u7ecf\u5e72\u7ec6\u80de\u81ea\u6211\u66f4\u65b0\u6216\u5206\u5316<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-19\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/nsc\/19266.html\/#2%E3%80%81%E7%A5%9E%E7%BB%8F%E8%8A%82%E8%8B%B7%E8%84%82%E4%BF%83%E8%BF%9B%E7%A5%9E%E7%BB%8F%E5%B9%B2%E7%BB%86%E8%83%9E%E8%87%AA%E6%88%91%E6%9B%B4%E6%96%B0\" >2\u3001\u795e\u7ecf\u8282\u82f7\u8102\u4fc3\u8fdb\u795e\u7ecf\u5e72\u7ec6\u80de\u81ea\u6211\u66f4\u65b0<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-20\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/nsc\/19266.html\/#%E4%B8%89%E3%80%81%E5%A4%96%E6%BA%90%E6%80%A7%E7%A5%9E%E7%BB%8F%E5%B9%B2%E7%BB%86%E8%83%9E%E7%A7%BB%E6%A4%8D\" >\u4e09\u3001\u5916\u6e90\u6027\u795e\u7ecf\u5e72\u7ec6\u80de\u79fb\u690d<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-21\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/nsc\/19266.html\/#%E6%9C%AA%E6%9D%A5%E6%96%B9%E5%90%91\" >\u672a\u6765\u65b9\u5411<\/a><\/li><\/ul><\/li><\/ul><\/nav><\/div>\n<h1 id=\"h-\u4ece\u9759\u606f\u5230\u6fc0\u6d3b-\u9776\u5411\u8111\u5ba4\u4e0b\u533a\u7684\u795e\u7ecf\u5e72\u7ec6\u80de\u5b9e\u73b0\u5e15\u91d1\u68ee\u75c5\u539f\u4f4d\u795e\u7ecf\u518d\u751f\"><span class=\"ez-toc-section\" id=\"%E4%BB%8E%E9%9D%99%E6%81%AF%E5%88%B0%E6%BF%80%E6%B4%BB%EF%BC%9A%E5%9B%9E%E8%BE%93%E5%B9%B2%E7%BB%86%E8%83%9E%E4%BF%83%E4%BD%BF%E9%9D%B6%E5%90%91%E8%84%91%E5%AE%A4%E4%B8%8B%E5%8C%BA%E7%9A%84%E7%A5%9E%E7%BB%8F%E5%B9%B2%E7%BB%86%E8%83%9E%E5%AE%9E%E7%8E%B0%E5%B8%95%E9%87%91%E6%A3%AE%E7%97%85%E5%8E%9F%E4%BD%8D%E7%A5%9E%E7%BB%8F%E5%86%8D%E7%94%9F\"><\/span>From resting to activation: back infusion of stem cells prompts neural regeneration in situ in Parkinson's disease by targeting neural stem cells in the subventricular zone<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<p>\u8fd1\u65e5\uff0c\u77e5\u540d\u533b\u5b66\u7f51\u7ad9\u300aStem Cell Reports\u300b\u4e0a\u520a\u53d1\u4e86\u4e00\u9879\u6709\u5173\u201c\u8111\u5ba4\u4e0b\u533a\u7684\u795e\u7ecf\u5e72\u7ec6\u80de\uff1a\u4fee\u590d\u5e15\u91d1\u68ee\u75c5\u5927\u8111\u7684\u6f5c\u5728\u5e72\u7ec6\u80de\u5e93\u201d\u7684\u7814\u7a76\u7efc\u8ff0\u3002<\/p>\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/09\/20250924201743-68d3e16735084.jpg\" alt=\"\" title=\"\"><figcaption><\/figcaption><\/figure>\n<p>\u5728\u672c\u7efc\u8ff0\u4e2d\uff0c\u6211\u4eec\u8ba8\u8bba\u4e86\u5e15\u91d1\u68ee\u75c5\u75c5\u7406\u5982\u4f55\u5f71\u54cd\u795e\u7ecf\u5e72\u7ec6\u80de\u7684\u884c\u4e3a\uff0c\u4ee5\u53ca\u76ee\u524d\u4fc3\u8fdb\u5e15\u91d1\u68ee\u75c5\u518d\u751f\u7684\u836f\u7406\u5b66\u7b56\u7565\u3002\u56de\u8f93SVZ\u7684\u795e\u7ecf\u5e72\u7ec6\u80de\u53ef\u4ee5\u4f5c\u4e3a\u8111\u4fee\u590d\u7684\u5e72\u7ec6\u80de\u6765\u6e90\uff0c\u672a\u6765\u7684\u7814\u7a76\u5e94\u8be5\u80fd\u591f\u9610\u660e\u8fd9\u4e9b\u5e72\u7ec6\u80de\u662f\u5426\u6709\u53ef\u80fd\u4ea7\u751f\u529f\u80fd\u6027\u795e\u7ecf\u5143\u7ec6\u80de\u3002<\/p>\n<h2 id=\"h-\u5e15\u91d1\u68ee\u75c5-\u6d41\u884c\u75c5\u5b66-\u75c5\u7406\u673a\u5236\u4e0e\u6cbb\u7597\u6311\u6218\u7684\u4e09\u91cd\u7ef4\u5ea6\"><span class=\"ez-toc-section\" id=\"%E5%B8%95%E9%87%91%E6%A3%AE%E7%97%85%EF%BC%9A%E6%B5%81%E8%A1%8C%E7%97%85%E5%AD%A6%E3%80%81%E7%97%85%E7%90%86%E6%9C%BA%E5%88%B6%E4%B8%8E%E6%B2%BB%E7%96%97%E6%8C%91%E6%88%98%E7%9A%84%E4%B8%89%E9%87%8D%E7%BB%B4%E5%BA%A6\"><\/span>\u5e15\u91d1\u68ee\u75c5\uff1a\u6d41\u884c\u75c5\u5b66\u3001\u75c5\u7406\u673a\u5236\u4e0e\u6cbb\u7597\u6311\u6218\u7684\u4e09\u91cd\u7ef4\u5ea6<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><strong>\u6d41\u884c\u75c5\u5b66\u7279\u5f81\u4e0e\u75c5\u56e0\uff1a<\/strong>\u5e15\u91d1\u68ee\u75c5\uff08PD\uff09\u662f\u7b2c\u4e8c\u5927\u5e38\u89c1\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\uff0c\u4e5f\u662f\u589e\u901f\u6700\u5feb\u7684\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u30022023\u5e74\u5168\u7403\u60a3\u8005\u8fbe850\u4e07\u4eba\uff0c\u9884\u8ba1\u52302040\u5e74\u5c06\u589e\u81f31290\u4e07\u3002\u7ea685%-90%\u75c5\u4f8b\u4e3a\u6563\u53d1\u6027\uff0c\u4ec510%-15%\u4e0e\u5bb6\u65cf\u9057\u4f20\u76f8\u5173\u3002\u5df2\u53d1\u73b0<strong>\u591a\u4e2a\u57fa\u56e0\u7a81\u53d8\u53ef\u5bfc\u81f4\u5355\u57fa\u56e0\u578bPD\u6216\u589e\u52a0\u60a3\u75c5\u98ce\u9669\uff0c\u5176\u4ed6\u98ce\u9669\u56e0\u7d20\u5305\u62ec\u8870\u8001\u3001\u519c\u836f\u7b49\u73af\u5883\u66b4\u9732<\/strong>The<\/p>\n<p><strong>\u75c5\u7406\u673a\u5236\u4e0e\u4e34\u5e8a\u8868\u73b0\uff1a<\/strong>\u8be5\u75c5\u4ee5\u8fd0\u52a8\u75c7\u72b6\uff08\u9707\u98a4\u3001\u8fd0\u52a8\u8fdf\u7f13\u3001\u808c\u5f3a\u76f4\uff09\u548c\u975e\u8fd0\u52a8\u75c7\u72b6\uff08\u8ba4\u77e5\u969c\u788d\u3001\u7761\u7720\u969c\u788d\u3001\u6291\u90c1\uff09\u4e3a\u4e34\u5e8a\u7279\u5f81\uff08\u56fe1\uff09\u3002<\/p>\n<p>\u6838\u5fc3\u75c5\u7406\u6539\u53d8\u662f<strong>\u9ed1\u8d28\u81f4\u5bc6\u90e8A9\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u4e22\u5931\uff0c\u5bfc\u81f4\u7eb9\u72b6\u4f53\u591a\u5df4\u80fa\u8017\u7aed\uff0c\u4ee5\u53ca\u03b1-\u7a81\u89e6\u6838\u86cb\u767d\uff08aSyn\uff09\u805a\u96c6\u5f62\u6210\u7684\u8def\u6613\u5c0f\u4f53<\/strong>\u3002\u75c5\u7406aSyn\u6700\u521d\u88ab\u8ba4\u4e3a\u4ece\u8111\u5e72\u8ff7\u8d70\u795e\u7ecf\u80cc\u6838\u548c\u524d\u55c5\u6838\u6269\u6563\u81f3\u5168\u8111\uff0c\u4f46\u5176\u7d2f\u79ef\u7a0b\u5ea6\u4e0e\u75c7\u72b6\u5e76\u975e\u5b8c\u5168\u5bf9\u5e94\uff0c\u63d0\u793a\u5b58\u5728\u5171\u75c5\u7406\u673a\u5236\u3002\u975e\u8fd0\u52a8\u75c7\u72b6\u6d89\u53ca\u80c6\u78b1\u80fd\u3001\u80be\u4e0a\u817a\u7d20\u80fd\u7b49\u591a\u7cfb\u7edf\u795e\u7ecf\u9012\u8d28\u7f3a\u635f\u3002<\/p>\n<figure class=\"aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/09\/20250924201743-68d3e16758e21.jpg\" alt=\"\u56fe1\uff1a\u5e15\u91d1\u68ee\u75c5\u7684\u4e34\u5e8a\u548c\u795e\u7ecf\u75c5\u7406\u5b66\u7279\u5f81\" width=\"367\" height=\"427\" title=\"\"><\/figure>\n<p><strong>\u6cbb\u7597\u73b0\u72b6\u4e0e\u672a\u6765\u65b9\u5411\uff1a<\/strong>\u73b0\u6709\u7597\u6cd5\u65e0\u6cd5\u963b\u65ad\u75be\u75c5\u8fdb\u5c55\u3002\u5de6\u65cb\u591a\u5df4\u66ff\u4ee3\u6cbb\u7597\u53ef\u7f13\u89e3\u8fd0\u52a8\u75c7\u72b6\uff0c\u6df1\u90e8\u8111\u523a\u6fc0\u672f\u53ef\u8c03\u8282\u57fa\u5e95\u8282\u529f\u80fd\uff0c\u6297\u6291\u90c1\u836f\u7b49\u8f85\u52a9\u6cbb\u7597\u80fd\u6539\u5584\u751f\u6d3b\u8d28\u91cf\u3002<strong>\u5e72\u7ec6\u80de\u7597\u6cd5\u901a\u8fc7\u66ff\u6362\u4e22\u5931\u795e\u7ecf\u5143\uff0c\u6210\u4e3a\u6781\u5177\u6f5c\u529b\u7684\u795e\u7ecf\u4fee\u590d\u7b56\u7565\uff0c\u4e9f\u5f85\u7a81\u7834\u73b0\u6709\u5bf9\u75c7\u6cbb\u7597\u7684\u5c40\u9650<\/strong>The<\/p>\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\"><p>\u9274\u4e8e\u73b0\u6709\u7597\u6cd5\u7684\u5c40\u9650\u6027\uff0c\u57fa\u4e8e\u5e72\u7ec6\u80de\u7684\u795e\u7ecf\u518d\u751f\u7b56\u7565\u6210\u4e3a\u7a81\u7834\u65b9\u5411\uff0c\u4e3b\u8981\u5305\u62ec\u4e09\u5927\u8def\u5f84\uff1a\u79fb\u690d\u66ff\u4ee3\u3001\u5185\u6e90\u6027\u6fc0\u6d3b\u4e0e\u795e\u7ecf\u518d\u751f\u8c03\u63a7\u3002<\/p><\/blockquote>\n<h2 id=\"h-\u5e72\u7ec6\u80de\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\u7684\u4e09\u7ef4\u8def\u5f84-\u79fb\u690d\u66ff\u4ee3-\u5185\u6e90\u6027\u6fc0\u6d3b\u4e0e\u795e\u7ecf\u518d\u751f\"><span class=\"ez-toc-section\" id=\"%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E5%B8%95%E9%87%91%E6%A3%AE%E7%97%85%E7%9A%84%E4%B8%89%E7%BB%B4%E8%B7%AF%E5%BE%84%EF%BC%9A%E7%A7%BB%E6%A4%8D%E6%9B%BF%E4%BB%A3%E3%80%81%E5%86%85%E6%BA%90%E6%80%A7%E6%BF%80%E6%B4%BB%E4%B8%8E%E7%A5%9E%E7%BB%8F%E5%86%8D%E7%94%9F\"><\/span>\u5e72\u7ec6\u80de\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\u7684\u4e09\u7ef4\u8def\u5f84\uff1a\u79fb\u690d\u66ff\u4ee3\u3001\u5185\u6e90\u6027\u6fc0\u6d3b\u4e0e\u795e\u7ecf\u518d\u751f<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<h3 id=\"h-01-\u79fb\u690d\u7597\u6cd5\u7684\u6f14\u8fdb\u4e0e\u7a81\u7834\" class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"01%E3%80%81%E7%A7%BB%E6%A4%8D%E7%96%97%E6%B3%95%E7%9A%84%E6%BC%94%E8%BF%9B%E4%B8%8E%E7%AA%81%E7%A0%B4\"><\/span><strong>01\u3001\u79fb\u690d\u7597\u6cd5\u7684\u6f14\u8fdb\u4e0e\u7a81\u7834<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u5e15\u91d1\u68ee\u75c5\uff08PD\uff09\u56e0\u7279\u5b9a\u8111\u533a\u795e\u7ecf\u5143\u9009\u62e9\u6027\u4e22\u5931\u7684\u7279\u5f81\uff0c\u957f\u671f\u88ab\u89c6\u4e3a\u7ec6\u80de\u66ff\u4ee3\u7597\u6cd5\u7684\u7406\u60f3\u9776\u70b9\u30021989\u5e74\u9996\u6b21\u5c06\u4eba\u80ce\u513f\u5e72\u7ec6\u80de\uff08FSCs\uff09\u7ecf\u7acb\u4f53\u5b9a\u4f4d\u6ce8\u5c04\u79fb\u690d\u81f3\u60a3\u8005\u7eb9\u72b6\u4f53\uff0c\u5b9e\u73b0\u4e34\u5e8a\u75c7\u72b6\u521d\u6b65\u6539\u5584\uff0c\u8be5\u7814\u7a76\u5960\u5b9a\u4e86\u79fb\u690d\u6cbb\u7597\u7684\u6982\u5ff5\u9a8c\u8bc1\u57fa\u7840\u3002<\/p>\n<p>\u8fd1\u5341\u5e74\u7814\u7a76\u62d3\u5c55\u81f3\u80da\u80ce\u5e72\u7ec6\u80de\uff08ESCs\uff09\u548c\u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de\uff08iPSCs\uff09\u7b49\u591a\u79cd\u6765\u6e90\uff0c\u5176\u4e2d\u81ea\u4f53iPSC\u6280\u672f\u7a81\u7834\u4f26\u7406\u9650\u5236\u5e76\u89c4\u907f\u514d\u75ab\u6392\u65a5\uff0c\u63a8\u52a8\u591a\u5df4\u80fa\u80fd\u7ec6\u80de\u66ff\u4ee3\u7597\u6cd5\u8fdb\u5165\u65b0\u9636\u6bb5\u3002<\/p>\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/09\/20250924201743-68d3e16764ff7.jpg\" alt=\"\" title=\"\"><\/figure>\n<h3 id=\"h-02-\u5185\u6e90\u6027\u4fee\u590d\u7684\u65b0\u8303\u5f0f\" class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"02%E3%80%81%E5%86%85%E6%BA%90%E6%80%A7%E4%BF%AE%E5%A4%8D%E7%9A%84%E6%96%B0%E8%8C%83%E5%BC%8F\"><\/span><strong>02\u3001\u5185\u6e90\u6027\u4fee\u590d\u7684\u65b0\u8303\u5f0f<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u9488\u5bf9\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u53ca\u8111\u635f\u4f24\uff0c\u6fc0\u6d3b\u5185\u6e90\u6027\u795e\u7ecf\u5e72\u7ec6\u80de\uff08NSCs\uff09\u6210\u4e3a\u65b0\u5174\u7b56\u7565\u3002\u6210\u5e74\u54fa\u4e73\u52a8\u7269\u8111\u5185\u795e\u7ecf\u53d1\u751f\u533a\u6301\u7eed\u5b58\u5728NSCs\uff0c\u5176\u5728\u8870\u8001\/\u75c5\u53d8\u8111\u4e2d\u4ecd\u5177\u6d3b\u6027\u3002\u4f46\u6210\u5e74\u8111\u5185NSCs\u591a\u5904\u4e8e\u9759\u606f\u72b6\u6001\uff0c\u9700\u901a\u8fc7\u6cbb\u7597\u7b56\u7565\u6fc0\u6d3b\u5176\u589e\u6b96\u5206\u5316\u80fd\u529b\u3002<\/p>\n<p>\u8be5\u9014\u5f84\u53ef\u540c\u65f6\u4fee\u590d\u591a\u5df4\u80fa\u80fd\u3001\u80c6\u78b1\u80fd\u53ca\u80be\u4e0a\u817a\u7d20\u80fd\u7cfb\u7edf\uff0c\u5bf9\u6539\u5584PD\u8fd0\u52a8\/\u8ba4\u77e5\u53cc\u91cd\u969c\u788d\u5177\u6709\u72ec\u7279\u4ef7\u503c\u3002<\/p>\n<h3 id=\"h-03-\u795e\u7ecf\u518d\u751f\u673a\u5236\u7684\u8f6c\u5316\u524d\u666f\" class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"03%E3%80%81%E7%A5%9E%E7%BB%8F%E5%86%8D%E7%94%9F%E6%9C%BA%E5%88%B6%E7%9A%84%E8%BD%AC%E5%8C%96%E5%89%8D%E6%99%AF\"><\/span><strong>03\u3001\u795e\u7ecf\u518d\u751f\u673a\u5236\u7684\u8f6c\u5316\u524d\u666f<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u672c\u7efc\u8ff0\u5c06\u7cfb\u7edf\u63a2\u8ba8\uff1a<strong>\u2460\u6210\u5e74\u8111\u795e\u7ecf\u518d\u751f\u7684\u5206\u5b50\u8c03\u63a7\u673a\u5236\uff1b\u2461PD\u75c5\u7406\u5bf9NSCs\u884c\u4e3a\u7684\u5f71\u54cd\uff1b\u2462\u4fc3\u8fdb\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u518d\u751f\u7684\u836f\u7406\u7b56\u7565<\/strong>The<\/p>\n<p>\u901a\u8fc7\u89e3\u6790\u795e\u7ecf\u53d1\u751f\u7684\u5185\u6e90\u8c03\u63a7\u7f51\u7edc\uff08\u5982\u9759\u606f\u6001\u6fc0\u6d3b\u3001\u5b9a\u5411\u5206\u5316\u7b49\uff09\uff0c\u4e3a\u5f00\u53d1\u201d\u5524\u9192\u201d\u8111\u81ea\u4fee\u590d\u80fd\u529b\u7684\u65b0\u578b\u7597\u6cd5\u63d0\u4f9b\u7406\u8bba\u6846\u67b6\uff0c\u6700\u7ec8\u63a8\u52a8PD\u795e\u7ecf\u518d\u751f\u6cbb\u7597\u7684\u4e34\u5e8a\u8f6c\u5316\u3002<\/p>\n<h2 id=\"h-\u4ec0\u4e48\u662f\u6210\u4ebasvz\u4e2d\u7684\u795e\u7ecf\u5e72\u7ec6\u80de-\u5e73\u8861\u9759\u6b62\u548c\u6fc0\u6d3b\"><span class=\"ez-toc-section\" id=\"%E4%BB%80%E4%B9%88%E6%98%AF%E6%88%90%E4%BA%BASVZ%E4%B8%AD%E7%9A%84%E7%A5%9E%E7%BB%8F%E5%B9%B2%E7%BB%86%E8%83%9E%EF%BC%9A%E5%B9%B3%E8%A1%A1%E9%9D%99%E6%AD%A2%E5%92%8C%E6%BF%80%E6%B4%BB%EF%BC%9F\"><\/span>\u4ec0\u4e48\u662f\u6210\u4ebaSVZ\u4e2d\u7684\u795e\u7ecf\u5e72\u7ec6\u80de\uff1a\u5e73\u8861\u9759\u6b62\u548c\u6fc0\u6d3b\uff1f<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>\u6210\u5e74\u54fa\u4e73\u52a8\u7269\u8111\u5185\u6709\u4e24\u4e2a\u795e\u7ecf\u53d1\u751f\u5fae\u73af\u5883\uff1a\u6d77\u9a6c\u9f7f\u72b6\u56de\u7684\u9897\u7c92\u4e0b\u533a\u548c\u4e0e\u4fa7\u8111\u5ba4\u5bf9\u9f50\u7684\u8111\u5ba4\u4e0b\u533a (SVZ)\u3002SVZ\u7531\u795e\u7ecf\u5e72\u7ec6\u80de\u3001\u4e0d\u540c\u7ec6\u80de\u8c31\u7cfb\u7684\u7956\u7ec6\u80de\uff08\u5373\u795e\u7ecf\u7956\u7ec6\u80de[NPC]\u548c\u5c11\u7a81\u80f6\u8d28\u7ec6\u80de\u7956\u7ec6\u80de\uff09\u3001\u795e\u7ecf\u6bcd\u7ec6\u80de\u3001\u5fae\u73af\u5883\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u3001\u5c0f\u80f6\u8d28\u7ec6\u80de\u548c\u5c11\u7a81\u80f6\u8d28\u7ec6\u80de\u7ec4\u6210\uff08\u56fe2\uff09\u3002<\/p>\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/09\/20250924201743-68d3e16771485.jpg\" alt=\"\u56fe2\uff1a\u4eba\u7c7bSVZ\u793a\u610f\u56fe\" width=\"656\" height=\"303\" title=\"\"><figcaption><\/figcaption><\/figure>\n<p><strong>\u4e24\u79cd\u72b6\u6001\u7684\u5b9a\u4e49\u4e0e\u7279\u5f81<\/strong><\/p>\n<p><strong>\u9759\u6b62NSC\uff1a<\/strong>\u9759\u6b62\u72b6\u6001\u7684\u795e\u7ecf\u5e72\u7ec6\u80de\uff08NSC\uff09\u662f\u7f13\u6162\u5faa\u73af\u6216\u8fd1\u4e4e\u4f11\u7720\u7684\u7ec6\u80de\uff0c\u57fa\u672c\u4e0d\u8fdb\u884c\u5206\u88c2\u589e\u6b96\u3002\u5b83\u4eec\u7684\u5173\u952e\u7279\u5f81\u5305\u62ec\u7f3a\u4e4f\u589e\u6b96\u6807\u5fd7\u7269\u3001\u4e0d\u8868\u8fbe\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff08Egfr\uff09\u548cNestin\u86cb\u767d\u3002<\/p>\n<p>\u9759\u6b62NSC\u7684\u4e3b\u8981\u529f\u80fd\u662f\u4f5c\u4e3a\u201c\u5e72\u7ec6\u80de\u6c60\u201d\uff0c\u957f\u671f\u7ef4\u6301\u6210\u4f53\u795e\u7ecf\u5e72\u7ec6\u80de\u5e93\uff0c\u662f\u795e\u7ecf\u53d1\u751f\u7684\u50a8\u5907\u529b\u91cf\u3002\u8fd9\u79cd\u9759\u6b62\u72b6\u6001\u662f\u53ef\u9006\u7684\uff0c\u5728\u7279\u5b9a\u4fe1\u53f7\u523a\u6fc0\u4e0b\u80fd\u591f\u88ab\u91cd\u65b0\u6fc0\u6d3b\u3002\u5b83\u4eec\u901a\u5e38\u6765\u6e90\u4e8e\u80da\u80ce\u53d1\u80b2\u65f6\u671f\u7684\u6162\u5faa\u73af\/\u9759\u6b62\u7956\u7ec6\u80de\u7fa4\u3002<\/p>\n<p><strong>\u6d3b\u5316NSC\uff1a<\/strong>\u6d3b\u5316\u72b6\u6001\u7684\u795e\u7ecf\u5e72\u7ec6\u80de\uff08NSC\uff09\u5219\u5904\u4e8e\u6d3b\u8dc3\u589e\u6b96\u671f\u3002\u5b83\u4eec\u5728\u4f53\u5185\u5177\u6709\u795e\u7ecf\u6e90\u6027\uff0c\u80fd\u591f\u76f4\u63a5\u4ea7\u751f\u540e\u4ee3\u7ec6\u80de\uff08\u5982\u795e\u7ecf\u7956\u7ec6\u80de\u3001\u795e\u7ecf\u6bcd\u7ec6\u80de\u7b49\uff09\uff0c\u5e76\u5728\u4f53\u5916\u57f9\u517b\u4e2d\u80fd\u5f62\u6210\u795e\u7ecf\u7403\u3002<\/p>\n<p>\u6d3b\u5316NSC\u662f\u795e\u7ecf\u53d1\u751f\u8fc7\u7a0b\u4e2d\u6d3b\u8dc3\u7684\u201c\u751f\u4ea7\u8005\u201d\u3002\u5176\u795e\u7ecf\u53d1\u751f\u8f93\u51fa\u5b58\u5728\u7269\u79cd\u5dee\u5f02\uff1a\u5728\u556e\u9f7f\u52a8\u7269\u4e2d\uff0c\u6d3b\u5316NSC\u4e3b\u8981\u4ea7\u751f\u8fc1\u79fb\u81f3\u55c5\u7403\u5e76\u6574\u5408\u5165\u7f51\u7edc\u7684\u795e\u7ecf\u5143\uff1b\u800c\u5728\u4eba\u7c7b\u4e2d\uff0c\u5b83\u4eec\u5219\u4ea7\u751f\u8fc1\u79fb\u81f3\u7eb9\u72b6\u4f53\u7684\u5c11\u91cf\u9499\u8c03\u86cb\u767d\u4e2d\u95f4\u795e\u7ecf\u5143\u3002<\/p>\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/09\/20250924201743-68d3e1677cb0d.jpg\" alt=\"\u56fe3\uff1a\u6d3b\u8dc3\u548c\u9759\u6b62\u795e\u7ecf\u5e72\u7ec6\u80de\u4e4b\u95f4\u7684\u5dee\u5f02\" width=\"507\" height=\"234\" title=\"\"><figcaption class=\"wp-element-caption\"><\/figcaption><\/figure>\n<figure class=\"aligncenter size-full\"><strong>\u7ef4\u6301\u795e\u7ecf\u5e72\u7ec6\u80de\u5e73\u8861\u7684\u91cd\u8981\u6027\uff1a<\/strong><\/figure>\n<p><strong>\u7ef4\u6301\u5e72\u7ec6\u80de\u5e93\uff1a<\/strong>\u4fdd\u6301\u4e00\u90e8\u5206NSC\u5904\u4e8e\u9759\u6b62\u72b6\u6001\u5bf9\u4e8e\u9632\u6b62\u5e72\u7ec6\u80de\u5e93\u5728\u7a33\u6001\u6761\u4ef6\u4e0b\u56e0\u8fc7\u5ea6\u6d88\u8017\u800c\u67af\u7aed\u81f3\u5173\u91cd\u8981\u3002\u8fd9\u786e\u4fdd\u4e86\u795e\u7ecf\u53d1\u751f\u80fd\u591f\u957f\u671f\u6301\u7eed\u3002<\/p>\n<p><strong>\u5e94\u5bf9\u9700\u6c42\u4e0e\u635f\u4f24\uff1a<\/strong>\u9759\u6b62\u7684NSC\u4f5c\u4e3a\u4e00\u4e2a\u50a8\u5907\u6c60\uff0c\u53ef\u4ee5\u5728\u9700\u8981\u65f6\uff08\u5982\u635f\u4f24\u540e\u3001\u7279\u5b9a\u751f\u7406\u4fe1\u53f7\u523a\u6fc0\u4e0b\uff09\u88ab\u6fc0\u6d3b\uff0c\u8865\u5145\u6d3b\u5316\u7684NSC\u7fa4\u4f53\uff0c\u4ece\u800c\u653e\u5927\u795e\u7ecf\u53d1\u751f\u53cd\u5e94\u3002\u6709\u8bc1\u636e\u8868\u660e\u9759\u6b62 NSC \u53ef\u80fd\u5bf9\u73af\u5883\u4fe1\u53f7\uff08\u5982\u635f\u4f24\u4fe1\u53f7\uff09\u66f4\u654f\u611f\u3002<\/p>\n<p><strong>\u9002\u5e94\u8870\u8001\uff1a<\/strong>\u968f\u7740\u5e74\u9f84\u589e\u957f\uff0cNSC\u503e\u5411\u4e8e\u66f4\u591a\u5730\u8fdb\u5165\u9759\u6b62\u72b6\u6001\uff0c\u5bfc\u81f4\u795e\u7ecf\u53d1\u751f\u51cf\u5c11\u3002\u7406\u89e3\u5e73\u8861\u673a\u5236\u662f\u5bfb\u627e\u4fc3\u8fdb\u8001\u5e74\u5927\u8111\u795e\u7ecf\u518d\u751f\u7b56\u7565\u7684\u5173\u952e\u3002<\/p>\n<h3 id=\"h-\u8c03\u8282\u795e\u7ecf\u5e72\u7ec6\u80de\u5e73\u8861\u7684\u4e24\u5927\u6838\u5fc3\u673a\u5236\" class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E8%B0%83%E8%8A%82%E7%A5%9E%E7%BB%8F%E5%B9%B2%E7%BB%86%E8%83%9E%E5%B9%B3%E8%A1%A1%E7%9A%84%E4%B8%A4%E5%A4%A7%E6%A0%B8%E5%BF%83%E6%9C%BA%E5%88%B6\"><\/span><strong>\u8c03\u8282\u795e\u7ecf\u5e72\u7ec6\u80de\u5e73\u8861\u7684\u4e24\u5927\u6838\u5fc3\u673a\u5236<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><strong>\u795e\u7ecf\u5e72\u7ec6\u80de\u5185\u5728\u8c03\u63a7\u673a\u5236 (\u7ec6\u80de\u81ea\u4e3b)\uff1a<\/strong><\/p>\n<p><strong>\u7ec6\u80de\u5468\u671f\u8c03\u63a7\u56e0\u5b50\uff1a<\/strong>\u5982\u7ec6\u80de\u5468\u671f\u86cb\u767d\u4f9d\u8d56\u6027\u6fc0\u9176\u6291\u5236\u5242P57\u5728\u7ef4\u6301\u9759\u6b62\u4e2d\u8d77\u91cd\u8981\u4f5c\u7528\u3002<\/p>\n<p><strong>Notch\u4fe1\u53f7\u901a\u8def\uff1a<\/strong>Notch\u4fe1\u53f7\uff08\u5c24\u5176\u662f\u5176\u6548\u5e94\u5b50\u5982 Hey1\uff09\u5728\u80da\u80ce\u7956\u7ec6\u80de\u9759\u6b62\u7684\u5efa\u7acb\u548c\u7ef4\u6301\u4e2d\u81f3\u5173\u91cd\u8981\uff0c\u6210\u5e74\u671f Notch2\/Notch3\u4e5f\u88ab\u8bc1\u660e\u901a\u8fc7\u6291\u5236\u7ec6\u80de\u5468\u671f\u8fdb\u7a0b\u57fa\u56e0\u6765\u4fc3\u8fdb\u9759\u6b62\u3002<\/p>\n<p><strong>\u7c98\u9644\u5206\u5b50\uff1a<\/strong>\u5982Vcam1\u5728\u80da\u80ce\u671f\u6162\u5faa\u73afNSC\u4e2d\u8868\u8fbe\uff0c\u5bf9\u8c03\u8282\u9759\u6b62\u671f\u548c\u7ef4\u6301\u51fa\u751f\u540eNSC\u5e93\u5927\u5c0f\u5f88\u91cd\u8981\u3002<\/p>\n<p><strong>\u5faeRNA\uff1a<\/strong>\u5982miR-17-92\u7684\u8868\u8fbe\u589e\u52a0\u4f1a\u4fc3\u8fdb\u6d3b\u5316\uff08\u589e\u6b96\u548c\u795e\u7ecf\u53d1\u751f\uff09\u3002<\/p>\n<p><strong>\u6eb6\u9176\u4f53\u6d3b\u6027\uff1a<\/strong>\u6eb6\u9176\u4f53\u6d3b\u5316\u662fNSC\u9000\u51fa\u9759\u6b62\u72b6\u6001\u6240\u5fc5\u9700\u7684\u3002\u8870\u8001\u65f6\u6eb6\u9176\u4f53\u6d3b\u6027\u964d\u4f4e\uff0c\u963b\u788d\u4e86\u91cd\u65b0\u6fc0\u6d3b\u7684\u80fd\u529b\u3002\u589e\u5f3a\u6eb6\u9176\u4f53\u964d\u89e3\u53cd\u800c\u6709\u52a9\u4e8e\u7ef4\u6301\u9759\u6b62\u3002<\/p>\n<p><strong>\u4ee3\u8c22\u72b6\u6001\uff1a<\/strong>\u9759\u6b62\u548c\u6d3b\u5316NSC\u7684\u4ee3\u8c22\u7279\u5f81\u5b58\u5728\u5dee\u5f02\u3002<\/p>\n<p><strong>\u795e\u7ecf\u5e72\u7ec6\u80de\u7684\u5916\u5728\u8c03\u63a7\u673a\u5236 (\u5fae\u73af\u5883\u4fe1\u53f7)\uff1a<\/strong><\/p>\n<p><strong>Wnt\u4fe1\u53f7\u901a\u8def\uff1a<\/strong>\u662f\u5173\u952e\u7684\u6d3b\u5316\u4fe1\u53f7\u3002\u5176\u6291\u5236\u5242Sfrp5\u5728\u8870\u8001NSC\u4e2d\u589e\u52a0\uff0c\u6291\u5236Wnt\u901a\u8def\u5bfc\u81f4\u9759\u6b62\u589e\u52a0\u3002\u6fc0\u6d3bWnt\u901a\u8def\u53ef\u4ee5\u4fc3\u8fdb\u9759\u6b62NSC\u7684\u518d\u6fc0\u6d3b\u548c\u589e\u6b96\u3002\u975e\u7ecf\u5178Wnt\u4fe1\u53f7\u4e0b\u6e38\u7684Cdc42\u4e5f\u53c2\u4e0e\u7ef4\u6301\u9759\u6b62\u3002<\/p>\n<p><strong>\u9aa8\u5f62\u6001\u53d1\u751f\u86cb\u767d (BMP) \u4fe1\u53f7\uff1a<\/strong>Bmp-4\u4fe1\u53f7\u8bf1\u5bfc\u9759\u6b62\u72b6\u6001\u3002<\/p>\n<p><strong>\u6210\u7ea4\u7ef4\u7ec6\u80de\u751f\u957f\u56e0\u5b50 (FGF) \u4fe1\u53f7\uff1a<\/strong>Fgf-2\u4e0eBmp-4\u7ed3\u5408\uff0c\u53ef\u4ee5\u8bf1\u5bfc\u4e00\u79cd\u201c\u542f\u52a8\u9759\u6b62\u201d\u72b6\u6001\uff0c\u4f7fNSC\u66f4\u5bb9\u6613\u88ab\u6fc0\u6d3b\u3002\u5904\u4e8e\u6b64\u72b6\u6001\u7684NSC\u9ad8\u8868\u8fbeLrig1\uff0c\u6291\u5236Lrig1\u4f1a\u4fc3\u8fdb\u589e\u6b96\u3002<\/p>\n<p><strong>\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53 (EGFR) \u4fe1\u53f7\uff1a<\/strong>Egfr\u53ca\u5176\u4e0b\u6e38\u4fe1\u53f7\u901a\u8def (PI3K\/Akt, Mek\/Erk, mTOR) \u662f\u5f3a\u6709\u529b\u7684\u589e\u6b96\/\u6d3b\u5316\u4fe1\u53f7\u3002<\/p>\n<p><strong>\u708e\u75c7\u4fe1\u53f7\uff1a<\/strong>\u8870\u8001\u8fc7\u7a0b\u4e2d\u708e\u75c7\u4fe1\u53f7\u589e\u52a0\u4e0e\u9759\u6b62\u72b6\u6001\u589e\u52a0\u6709\u5173\u3002<\/p>\n<p><strong>\u5f02\u8d28\u6027\uff1a<\/strong>\u5355\u7ec6\u80de RNA \u6d4b\u5e8f\u63ed\u793aSVZ\u4e2dNSC\u5b58\u5728\u4ece\u9759\u6b62\u5230\u6d3b\u5316\u7684\u8fde\u7eed\u68af\u5ea6\u72b6\u6001\uff0c\u53cd\u6620\u4e86\u5fae\u73af\u5883\u4fe1\u53f7\u548c\u5185\u5728\u72b6\u6001\u7684\u590d\u6742\u6027\u3002<\/p>\n<p><strong>\u603b\u7ed3\u6765\u8bf4\uff1a<\/strong>\u6210\u4ebaSVZ\u4e2d\u7684\u795e\u7ecf\u5e72\u7ec6\u80de\u901a\u8fc7\u7cbe\u7ec6\u8c03\u63a7\u7684\u5185\u5728\u5206\u5b50\u7a0b\u5e8f\uff08\u5982P57, Notch, Vcam1, \u6eb6\u9176\u4f53\u6d3b\u6027, miRNA\uff09 \u548c\u5916\u5728\u5fae\u73af\u5883\u4fe1\u53f7\uff08\u5982Wnt, BMP, FGF, EGFR, \u708e\u75c7\u56e0\u5b50\uff09 \u5728\u9759\u6b62\uff08\u4f11\u7720\u50a8\u5907\uff09 \u548c\u6fc0\u6d3b\uff08\u589e\u6b96\u5206\u5316\uff09 \u72b6\u6001\u4e4b\u95f4\u4fdd\u6301\u52a8\u6001\u5e73\u8861\u3002<\/p>\n<p>\u8fd9\u79cd\u5e73\u8861\u5bf9\u4e8e\u957f\u671f\u7ef4\u6301\u795e\u7ecf\u5e72\u7ec6\u80de\u5e93\u3001\u4fdd\u969c\u7ec8\u751f\u795e\u7ecf\u53d1\u751f\u7684\u6f5c\u529b\u3001\u4ee5\u53ca\u54cd\u5e94\u635f\u4f24\u548c\u751f\u7406\u9700\u6c42\u81f3\u5173\u91cd\u8981\u3002\u968f\u7740\u5e74\u9f84\u589e\u957f\u6216\u75c5\u7406\u72b6\u6001\uff0c\u8fd9\u79cd\u5e73\u8861\u4f1a\u5411\u9759\u6b62\u503e\u659c\uff0c\u5bfc\u81f4\u795e\u7ecf\u53d1\u751f\u51cf\u5c11\u3002\u7406\u89e3\u8fd9\u4e9b\u8c03\u63a7\u673a\u5236\u4e3a\u672a\u6765\u5f00\u53d1\u4fc3\u8fdb\u795e\u7ecf\u518d\u751f\u548c\u4fee\u590d\u7684\u7b56\u7565\u63d0\u4f9b\u4e86\u7406\u8bba\u57fa\u7840\u3002<\/p>\n<h2 id=\"h-\u5e15\u91d1\u68ee\u75c5\u7684\u795e\u7ecf\u53d1\u751f\"><span class=\"ez-toc-section\" id=\"%E5%B8%95%E9%87%91%E6%A3%AE%E7%97%85%E7%9A%84%E7%A5%9E%E7%BB%8F%E5%8F%91%E7%94%9F\"><\/span>\u5e15\u91d1\u68ee\u75c5\u7684\u795e\u7ecf\u53d1\u751f<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><strong>\u795e\u7ecf\u5e72\u7ec6\u80de\u6c60\u7684\u5b58\u7559\u6027\u4e0e\u4e34\u5e8a\u542f\u793a\uff1a<\/strong>\u4e3a\u4e86\u80fd\u591f\u4fc3\u8fdbPD\u60a3\u8005\u7684\u795e\u7ecf\u53d1\u751f\uff0c\u9996\u5148\u9700\u8981\u89e3\u51b3\u7684\u95ee\u9898\u662f\u8fd9\u4e2aNSC\u6c60\u662f\u5426\u4ecd\u5b58\u5728\u4e8e\u60a3\u75c5\u7684PD\u5927\u8111\u4e2d\u3002<\/p>\n<p>\u6211\u4eec\u901a\u8fc7\u4e34\u5e8a\u7814\u7a76\u8868\u660e\uff1aPD\u60a3\u8005SVZ\u533aNSCs\u6570\u91cf\u4e0e\u5065\u5eb7\u4eba\u65e0\u663e\u8457\u5dee\u5f02\uff0c\u8bc1\u5b9e\u75c5\u53d8\u8111\u5185\u4ecd\u4fdd\u6709\u795e\u7ecf\u518d\u751f\u6f5c\u529b\u3002\u4f46\u5c38\u68c0\u7814\u7a76\u4ec5\u6355\u6349\u7ec8\u672b\u671f\u72b6\u6001\uff0c\u9700\u8b66\u60d5\u65f6\u95f4\u52a8\u6001\u5dee\u5f02\uff1a\u65e9\u671fPD\u7684NSCs\u884c\u4e3a\u53ef\u80fd\u5b8c\u5168\u4e0d\u540c\u3002<\/p>\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\"><p>\u6838\u5fc3\u672a\u89e3\u95ee\u9898\u662f\uff1a\u73b0\u5b58NSCs\u6c60\u80fd\u5426\u901a\u8fc7\u6269\u589e\u8865\u5145\u8db3\u91cf\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\uff1f<\/p><\/blockquote>\n<p>\u5df2\u8bc1\u660ePD\u7684\u75c5\u7406\u7279\u5f81\u548c\u591a\u79cd\u9057\u4f20\u56e0\u7d20\u4f1a\u5f71\u54cdNSC\u7684\u589e\u6b96\u548c\u5206\u5316\u80fd\u529b\uff08\u56fe4\uff09\u3002\u4e3a\u4e86\u6210\u529f\u5f00\u53d1\u523a\u6fc0\u795e\u7ecf\u53d1\u751f\u7684\u6cbb\u7597\u65b9\u6cd5\uff0c\u9700\u8981\u786e\u5b9a\u75c5\u7406\u548c\u57fa\u56e0\u7a81\u53d8\u5bf9NSC\u884c\u4e3a\u7684\u5f71\u54cd\u3002<strong>\u5728\u4e0b\u9762\u7684\u7ae0\u8282\u4e2d\uff0c\u6211\u4eec\u5c06\u8ba8\u8bba\u76ee\u524d\u5173\u4e8e\u591a\u5df4\u80fa\u8017\u7aed\u548c\u57fa\u56e0\u7a81\u53d8\u5982\u4f55\u5f71\u54cd\u795e\u7ecf\u5e72\u7ec6\u80de\u884c\u4e3a\u7684\u77e5\u8bc6\u3002<\/strong><\/p>\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/09\/20250924201743-68d3e16787462.jpg\" alt=\"\u56fe4\uff1a\u5f71\u54cd\u6210\u4eba\u795e\u7ecf\u53d1\u751f\u7684\u5e15\u91d1\u68ee\u75c5\u75c5\u7406\u7279\u5f81\" width=\"656\" height=\"530\" title=\"\"><figcaption class=\"wp-element-caption\"><\/figcaption><\/figure>\n<h2 id=\"h-\u5f71\u54cd\u6210\u4eba\u795e\u7ecf\u53d1\u751f\u7684\u5e15\u91d1\u68ee\u75c5\u75c5\u7406\u7279\u5f81\u6709\u54ea\u4e9b\"><span class=\"ez-toc-section\" id=\"%E5%BD%B1%E5%93%8D%E6%88%90%E4%BA%BA%E7%A5%9E%E7%BB%8F%E5%8F%91%E7%94%9F%E7%9A%84%E5%B8%95%E9%87%91%E6%A3%AE%E7%97%85%E7%9A%84%E7%97%85%E7%90%86%E7%89%B9%E5%BE%81%E6%9C%89%E5%93%AA%E4%BA%9B%EF%BC%9F\"><\/span>\u5f71\u54cd\u6210\u4eba\u795e\u7ecf\u53d1\u751f\u7684\u5e15\u91d1\u68ee\u75c5\u7684\u75c5\u7406\u7279\u5f81\u6709\u54ea\u4e9b\uff1f<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<h3 id=\"h-\u4e00-\u591a\u5df4\u80fa\u80fd\u7cfb\u7edf\u5d29\u6e83\u4e0e\u795e\u7ecf\u5fae\u73af\u5883\u5931\u8861\" class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E4%B8%80%E3%80%81%E5%A4%9A%E5%B7%B4%E8%83%BA%E8%83%BD%E7%B3%BB%E7%BB%9F%E5%B4%A9%E6%BA%83%E4%B8%8E%E7%A5%9E%E7%BB%8F%E5%BE%AE%E7%8E%AF%E5%A2%83%E5%A4%B1%E8%A1%A1\"><\/span><strong>\u4e00\u3001\u591a\u5df4\u80fa\u80fd\u7cfb\u7edf\u5d29\u6e83\u4e0e\u795e\u7ecf\u5fae\u73af\u5883\u5931\u8861<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><strong>\u7eb9\u72b6\u4f53\u591a\u5df4\u80fa\u8017\u7aed\uff1a<\/strong>\u9ed1\u8d28\u81f4\u5bc6\u90e8A9\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u8fdb\u884c\u6027\u4e22\u5931\uff0c\u5bfc\u81f4\u7eb9\u72b6\u4f53\u591a\u5df4\u80fa\u4e25\u91cd\u4e0d\u8db3\u3002<\/p>\n<p><strong>\u591a\u5df4\u80fa\u76f4\u63a5\u8c03\u63a7\u8111\u5ba4\u4e0b\u533a\uff08SVZ\uff09\u795e\u7ecf\u5e72\u7ec6\u80de\uff08NSC\uff09\u589e\u6b96\uff1a<\/strong>\u5b9e\u9a8c\u8868\u660e\uff0c\u591a\u5df4\u80faD2\u53d7\u4f53\u6fc0\u52a8\u5242\u53ef\u4fc3\u8fdbSVZ\u533aNSC\u5411\u795e\u7ecf\u5143\u5206\u5316\u3002<\/p>\n<p><strong>\u6548\u5e94\uff1a<\/strong>PD\u60a3\u8005\u591a\u5df4\u80fa\u7f3a\u5931\u663e\u8457\u6291\u5236SVZ\u795e\u7ecf\u53d1\u751f\uff0c\u524a\u5f31\u795e\u7ecf\u5143\u65b0\u751f\u80fd\u529b\u3002<\/p>\n<p><strong>Wnt\/\u03b2-catenin\u901a\u8def\u6291\u5236\uff1a<\/strong>PD\u75c5\u7406\u5fae\u73af\u5883\u4e2d\uff0cWnt\u6291\u5236\u56e0\u5b50\uff08\u5982Sfrp5\uff09\u7d2f\u79ef\uff0c\u963b\u65adWnt\u4fe1\u53f7\u4f20\u5bfc\u3002Wnt\u901a\u8def\u662fNSC\u5206\u5316\u4e3a\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u7684\u5173\u952e\u9a71\u52a8\u529b\uff1b\u5176\u6291\u5236\u5bfc\u81f4\u795e\u7ecf\u518d\u751f\u969c\u788d\u3002<\/p>\n<p>\u8bc1\u636e\uff1a\u6e05\u9664Sfrp5\u53ef\u91cd\u542f\u8001\u5e74\u5c0f\u9f20SVZ\u7684NSC\u589e\u6b96\u3002<\/p>\n<h3 id=\"h-\u4e8c-\u03b1-\u7a81\u89e6\u6838\u86cb\u767d\u75c5\u7406\u4e0e\u6bd2\u6027\u6269\u6563\" class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E4%BA%8C%E3%80%81%CE%B1-%E7%AA%81%E8%A7%A6%E6%A0%B8%E8%9B%8B%E7%99%BD%E7%97%85%E7%90%86%E4%B8%8E%E6%AF%92%E6%80%A7%E6%89%A9%E6%95%A3\"><\/span><strong>\u4e8c\u3001\u03b1-\u7a81\u89e6\u6838\u86cb\u767d\u75c5\u7406\u4e0e\u6bd2\u6027\u6269\u6563<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><strong>\u8def\u6613\u5c0f\u4f53\u5f62\u6210\u4e0e\u795e\u7ecf\u5143\u529f\u80fd\u969c\u788d\uff1a<\/strong>\u75c5\u7406\u6027\u03b1-\u7a81\u89e6\u6838\u86cb\u767d\uff08aSyn\uff09\u805a\u96c6\u6210\u8def\u6613\u5c0f\u4f53\uff0c\u76f4\u63a5\u635f\u4f24\u795e\u7ecf\u5143\u53caNSC\u5fae\u73af\u5883\u3002<\/p>\n<ul class=\"wp-block-list\">\n<li>aSyn\u5f02\u5e38\u805a\u96c6\u6291\u5236\u7ebf\u7c92\u4f53\u529f\u80fd\uff0c\u589e\u52a0\u6c27\u5316\u5e94\u6fc0\uff0c\u5bfc\u81f4NSC\u51cb\u4ea1\u3002<\/li>\n<\/ul>\n<p><strong>\u8de8\u8111\u533a\u75c5\u7406\u4f20\u64ad\uff1a<\/strong>aSyn\u4ece\u8111\u5e72\uff08\u8ff7\u8d70\u795e\u7ecf\u80cc\u6838\uff09\u5411\u55c5\u7403\u3001\u6d77\u9a6c\u53ca\u76ae\u8d28\u6269\u6563\uff08Braak\u5206\u671f\uff09\uff0c\u7834\u574f\u795e\u7ecf\u53d1\u751f\u5173\u952e\u533a\u57df\u3002<\/p>\n<p>\u4e34\u5e8a\u5173\u8054\uff1aaSyn\u5728\u55c5\u7403\u65e9\u671f\u7d2f\u79ef\u89e3\u91caPD\u60a3\u8005\u55c5\u89c9\u51cf\u9000\uff0c\u53cd\u6620\u795e\u7ecf\u53d1\u751f\u533a\u9996\u5f53\u5176\u51b2\u3002<\/p>\n<h3 id=\"h-\u4e09-\u795e\u7ecf\u708e\u75c7\u4e0e\u80f6\u8d28\u7ec6\u80de\u5f02\u5e38\u6d3b\u5316\" class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E4%B8%89%E3%80%81%E7%A5%9E%E7%BB%8F%E7%82%8E%E7%97%87%E4%B8%8E%E8%83%B6%E8%B4%A8%E7%BB%86%E8%83%9E%E5%BC%82%E5%B8%B8%E6%B4%BB%E5%8C%96\"><\/span><strong>\u4e09\u3001\u795e\u7ecf\u708e\u75c7\u4e0e\u80f6\u8d28\u7ec6\u80de\u5f02\u5e38\u6d3b\u5316<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><strong>\u5c0f\u80f6\u8d28\u7ec6\u80de\/\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u6fc0\u6d3b\uff1a<\/strong>\u75c5\u53d8\u8111\u533a\u4fc3\u708e\u56e0\u5b50\uff08TNF-\u03b1\u3001IL-1\u03b2\uff09\u5347\u9ad8\uff0c\u6fc0\u6d3bNF-\u03baB\u901a\u8def\uff0c\u76f4\u63a5\u6291\u5236NSC\u589e\u6b96\u3002\u53cd\u5e94\u6027\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u5206\u6cccBMP-4\uff0c\u8bf1\u5bfcNSC\u9759\u606f\u6001\uff0c\u963b\u904f\u795e\u7ecf\u518d\u751f\u3002<\/p>\n<p><strong>\u6eb6\u9176\u4f53-\u81ea\u566c\u7cfb\u7edf\u8870\u7aed\uff1a<\/strong>aSyn\u805a\u96c6\u7269\u5835\u585e\u81ea\u566c\u6d41\uff0c\u5bfc\u81f4\u5f02\u5e38\u86cb\u767d\u7d2f\u79ef\uff0c\u635f\u5bb3NSC\u81ea\u6211\u66f4\u65b0\u3002<\/p>\n<p>\u8870\u8001PD\u8111\u4e2d\u6eb6\u9176\u4f53\u6d3b\u6027\u4e0b\u964d\uff0c\u8fdb\u4e00\u6b65\u9650\u5236NSC\u9000\u51fa\u9759\u606f\u6001\u3002<\/p>\n<h2 id=\"h-\u4fc3\u8fdb\u5e15\u91d1\u68ee\u75c5\u795e\u7ecf\u53d1\u751f\u7684\u65b9\u6cd5\"><span class=\"ez-toc-section\" id=\"%E4%BF%83%E8%BF%9B%E5%B8%95%E9%87%91%E6%A3%AE%E7%97%85%E7%A5%9E%E7%BB%8F%E5%8F%91%E7%94%9F%E7%9A%84%E6%96%B9%E6%B3%95\"><\/span>\u4fc3\u8fdb\u5e15\u91d1\u68ee\u75c5\u795e\u7ecf\u53d1\u751f\u7684\u65b9\u6cd5<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>\u556e\u9f7f\u52a8\u7269\u6a21\u578b\u5df2\u8bc1\u660e\uff0c\u5982\u679c\u5f97\u5230\u9002\u5f53\u7684\u523a\u6fc0\uff0c\u9759\u6b62\u7684NSC\u53ef\u4ee5\u91cd\u65b0\u6fc0\u6d3b\u3002\u4f8b\u5982\uff0c\u4e0e\u91ce\u751f\u578b\u5c0f\u9f20\u76f8\u6bd4\uff0cMPTP\u5c0f\u9f20\u6a21\u578b\u7684\u9ed1\u8d28\u4e2dBrdU+\u548cTh+\u7ec6\u80de\u6709\u6240\u589e\u52a0\u3002<\/p>\n<p>\u56e0\u6b64\uff0c\u8fdb\u4e00\u6b65\u7814\u7a76\u53ef\u7528\u4e8e\u589e\u5f3aSVZ NSC\u518d\u751f\u80fd\u529b\u7684\u4e0d\u540c\u65b9\u6cd5\u975e\u5e38\u91cd\u8981\uff0c\u5305\u62ec\u4f7f\u7528\u591a\u5df4\u80fa\u6fc0\u52a8\u5242\u3001\u5c0f\u5206\u5b50\u3001\u751f\u957f\u56e0\u5b50\u548c\u8102\u8d28\u3002<\/p>\n<p><strong>\u5728\u4e0b\u4e00\u8282\u4e2d\uff0c\u6211\u4eec\u5c06\u8ba8\u8bba\u6b63\u5728\u7814\u7a76\u7684\u4e0d\u540c\u65b9\u6cd5\u5728\u556e\u9f7f\u52a8\u7269PD\u6a21\u578b\u4e2d\u91cd\u65b0\u6fc0\u6d3bNSC\u548c\u523a\u6fc0SVZ\u4e2d\u795e\u7ecf\u53d1\u751f\u7684\u6548\u679c\uff08\u56fe5\uff09\u3002<\/strong><\/p>\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/09\/20250924201743-68d3e16796310.jpg\" alt=\"\u56fe5\uff1a\u4fc3\u8fdb\u795e\u7ecf\u53d1\u751f\u4f5c\u4e3a\u5e15\u91d1\u68ee\u75c5\u6cbb\u7597\u65b9\u6cd5\u7684\u7b56\u7565\" width=\"656\" height=\"384\" title=\"\"><figcaption class=\"wp-element-caption\"><\/figcaption><\/figure>\n<h3 id=\"h-\u4e00-\u836f\u7269\u5e72\u9884-\u9776\u5411\u795e\u7ecf\u518d\u751f\u901a\u8def\" class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E4%B8%80%E3%80%81%E8%8D%AF%E7%89%A9%E5%B9%B2%E9%A2%84%EF%BC%9A%E9%9D%B6%E5%90%91%E7%A5%9E%E7%BB%8F%E5%86%8D%E7%94%9F%E9%80%9A%E8%B7%AF\"><\/span><strong>\u4e00\u3001\u836f\u7269\u5e72\u9884\uff1a\u9776\u5411\u795e\u7ecf\u518d\u751f\u901a\u8def<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><strong>1\u3001\u591a\u5df4\u80fa\u53d7\u4f53\u6fc0\u52a8\u5242\u4fc3\u8fdb\u795e\u7ecf\u5e72\u7ec6\u80de\u81ea\u6211\u66f4\u65b0<\/strong><\/p>\n<p>\u591a\u5df4\u80fa\u80fd\u836f\u7269\uff08\u5982\u5de6\u65cb\u591a\u5df4\u3001\u666e\u62c9\u514b\u7d22\uff09\u9664\u7f13\u89e3PD\u8fd0\u52a8\u75c7\u72b6\u5916\uff0c\u53ef\u6fc0\u6d3b\u795e\u7ecf\u5e72\u7ec6\u80de\u589e\u6b96\uff1a\u5c0f\u9f20\u6a21\u578b\u8bc1\u5b9e\u5176\u633d\u65516-OHDA\u635f\u4f24\u4fa7\u7684NSC\u81ea\u6211\u66f4\u65b0\u80fd\u529b\u3002<\/p>\n<p>\u5c40\u9650\u6027\uff1a\u4ec5\u4fc3\u8fdb\u55c5\u7403\u795e\u7ecf\u5143\u5206\u5316\uff0c\u96be\u4fee\u590d\u7eb9\u72b6\u4f53\u3002<\/p>\n<h4 id=\"h-2-\u7ecf\u5178wnt\u901a\u8def\u7684\u6fc0\u6d3b\u4fc3\u8fdb\u795e\u7ecf\u53d1\u751f\" class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"2%E3%80%81%E7%BB%8F%E5%85%B8Wnt%E9%80%9A%E8%B7%AF%E7%9A%84%E6%BF%80%E6%B4%BB%E4%BF%83%E8%BF%9B%E7%A5%9E%E7%BB%8F%E5%8F%91%E7%94%9F\"><\/span><strong>2\u3001\u7ecf\u5178Wnt\u901a\u8def\u7684\u6fc0\u6d3b\u4fc3\u8fdb\u795e\u7ecf\u53d1\u751f<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h4>\n<p>\u5982\u524d\u6240\u8ff0\uff0cWnt\/\u03b2-\u8fde\u73af\u86cb\u767d\u901a\u8def\u5728\u8c03\u63a7\u6210\u4eba\u795e\u7ecf\u53d1\u751f\u4e2d\u8d77\u5173\u952e\u4f5c\u7528\uff0c\u5176\u901a\u8def\u6210\u5458\u53ef\u4f5c\u4e3a\u4fc3\u8fdb\u795e\u7ecf\u518d\u751f\u7684\u6cbb\u7597\u9776\u70b9\u3002PD\u556e\u9f7f\u7c7b\u6a21\u578b\u53ca\u60a3\u8005\u8111\u4e2d\u6d3b\u5316\u578bGsk-3\u03b2\u6c34\u5e73\u5347\u9ad8\uff0c\u63d0\u793aWnt\u901a\u8def\u6d3b\u6027\u53d7\u6291\u3002Marchetti\u5b9e\u9a8c\u5ba4\u7814\u7a76\u8868\u660e\uff1a\u6fc0\u6d3bWnt\/\u03b2-catenin\u901a\u8def\u53ef\u589e\u5f3aSVZ\u795e\u7ecf\u53d1\u751f\u3002<\/p>\n<p>\u5173\u952e\u836f\u7269\uff1a<\/p>\n<figure class=\"wp-block-table is-style-stripes\">\n<table class=\"has-fixed-layout\">\n<thead>\n<tr>\n<th>\u6291\u5236\u5242<\/th>\n<th>\u6548\u5e94<\/th>\n<th>mould<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>AR-AO14418<\/td>\n<td>\u589e\u52a0\u9ed1\u8d28\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\uff0c\u6062\u590d\u7eb9\u72b6\u4f53Dat\u529f\u80fd<\/td>\n<td>MPTP\u5c0f\u9f20<\/td>\n<\/tr>\n<tr>\n<td>SB216763<\/td>\n<td>\u4fc3\u8fdb\u65b0\u751f\u795e\u7ecf\u5143\u5411\u7eb9\u72b6\u4f53\u8fc1\u79fb<\/td>\n<td>6-OHDA\u5c0f\u9f20<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/figure>\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\"><p>\u4f18\u52bf\uff1a\u7a81\u7834\u55c5\u7403\u5c40\u9650\uff0c\u5b9e\u73b0\u591a\u5df4\u80fa\u7f3a\u5931\u533a\u4fee\u590d\u3002<\/p><\/blockquote>\n<h3 id=\"h-\u4e8c-\u751f\u957f\u56e0\u5b50\u4e0e\u8102\u8d28\u8c03\u63a7\" class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E4%BA%8C%E3%80%81%E7%94%9F%E9%95%BF%E5%9B%A0%E5%AD%90%E4%B8%8E%E8%84%82%E8%B4%A8%E8%B0%83%E6%8E%A7\"><\/span><strong>\u4e8c\u3001\u751f\u957f\u56e0\u5b50\u4e0e\u8102\u8d28\u8c03\u63a7<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<h3 id=\"h-1-\u751f\u957f\u56e0\u5b50\u4fc3\u8fdb\u795e\u7ecf\u5e72\u7ec6\u80de\u81ea\u6211\u66f4\u65b0\u6216\u5206\u5316\" class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"1%E3%80%81%E7%94%9F%E9%95%BF%E5%9B%A0%E5%AD%90%E4%BF%83%E8%BF%9B%E7%A5%9E%E7%BB%8F%E5%B9%B2%E7%BB%86%E8%83%9E%E8%87%AA%E6%88%91%E6%9B%B4%E6%96%B0%E6%88%96%E5%88%86%E5%8C%96\"><\/span><strong>1\u3001\u751f\u957f\u56e0\u5b50\u4fc3\u8fdb\u795e\u7ecf\u5e72\u7ec6\u80de\u81ea\u6211\u66f4\u65b0\u6216\u5206\u5316<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u751f\u957f\u56e0\u5b50\uff08\u542b\u795e\u7ecf\u8425\u517b\u56e0\u5b50\uff09\u5bf9\u53d1\u80b2\u671f\u5927\u8111\u795e\u7ecf\u5e72\u7ec6\u80de\uff08NSC\uff09\u7684\u81ea\u6211\u66f4\u65b0\u4e0e\u5206\u5316\u81f3\u5173\u91cd\u8981\u3002\u6210\u5e74\u8111\u5ba4\u4e0b\u533a\uff08SVZ\uff09\u4e2d\uff0c\u751f\u6001\u4f4d\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u53ef\u63d0\u4f9b\u751f\u957f\u56e0\u5b50\uff0cNSCs\u4ea6\u63a5\u89e6\u5bcc\u542b\u751f\u957f\u56e0\u5b50\u7684\u8111\u810a\u6db2\u3002\u5728\u556e\u9f7f\u7c7bPD\u6a21\u578b\u4e2d\u7684\u7814\u7a76\u8868\u660e\uff1a<\/p>\n<p><strong>BDNF\u5e72\u9884<\/strong><strong>::<\/strong>\u9057\u4f20\u6027\u591a\u5df4\u80fa\u795e\u7ecf\u9000\u53d8\u5c0f\u9f20\uff08Girk2\u7a81\u53d8\uff09\u4e2d\uff0c\u8179\u8154\u6ce8\u5c04BNN-20\uff08P14-P60\uff09\u63d0\u5347\u8111\u6e90\u6027\u795e\u7ecf\u8425\u517b\u56e0\u5b50\uff08Bdnf\uff09\u6d53\u5ea6\uff0c\u4f7f\u9ed1\u8d28BrdU+\/Th+\u7ec6\u80de\u589e\u52a0\uff0c\u4f46SVZ\u7684Pcna+\u7ec6\u80de\u672a\u53d8\u3002P45\u8111\u5ba4\u6ce8\u5c04DiI\u793a\u8e2a\u8bc1\u5b9e\u65b0\u751f\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u6e90\u81eaSVZ\uff0c\u8868\u660e<strong>BDNF\u7279\u5f02\u6027\u4fc3\u8fdbNSC\u5206\u5316\u800c\u975e\u589e\u6b96<\/strong>The<\/p>\n<p><strong>\u591a\u56e0\u5b50\u6548\u5e94<\/strong><strong>::<\/strong>\u8111\u5ba4\u704c\u6ce8\u8868\u76ae\u751f\u957f\u56e0\u5b50\uff08Egf\uff09\u3001\u6210\u7ea4\u7ef4\u7ec6\u80de\u751f\u957f\u56e0\u5b502\uff08Fgf-2\uff09\u3001\u809d\u751f\u957f\u56e0\u5b50\uff08Lgf\uff09\u6216\u8111\u591a\u5df4\u80fa\u795e\u7ecf\u8425\u517b\u56e0\u5b50\uff0c\u53ef\u589e\u52a06-OHDA\u5927\u9f20SVZ\u5206\u88c2\u7ec6\u80de\u3002\u90e8\u5206\u7814\u7a76\u89c2\u5bdf\u5230\u8fd9\u4e9bBrdU+\u7ec6\u80de\u540c\u65f6\u8868\u8fbeDcx\uff08\u672a\u6210\u719f\u795e\u7ecf\u5143\u6807\u5fd7\uff09\uff0c\u5e76\u5411\u90bb\u8fd1\u7eb9\u72b6\u4f53\u8fc1\u79fb\u3002<\/p>\n<p><strong>\u672a\u89e3\u95ee\u9898<\/strong><strong>::<\/strong>\u9700\u660e\u786eDcx+\u7ec6\u80de\u80fd\u5426\u5728\u7eb9\u72b6\u4f53\u6210\u719f\u4e3a\u529f\u80fd\u6027\u795e\u7ecf\u5143\u5e76\u6539\u5584PD\u8fd0\u52a8\u75c7\u72b6\u3002<\/p>\n<h3 id=\"h-2-\u795e\u7ecf\u8282\u82f7\u8102\u4fc3\u8fdb\u795e\u7ecf\u5e72\u7ec6\u80de\u81ea\u6211\u66f4\u65b0\" class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"2%E3%80%81%E7%A5%9E%E7%BB%8F%E8%8A%82%E8%8B%B7%E8%84%82%E4%BF%83%E8%BF%9B%E7%A5%9E%E7%BB%8F%E5%B9%B2%E7%BB%86%E8%83%9E%E8%87%AA%E6%88%91%E6%9B%B4%E6%96%B0\"><\/span><strong>2\u3001\u795e\u7ecf\u8282\u82f7\u8102\u4fc3\u8fdb\u795e\u7ecf\u5e72\u7ec6\u80de\u81ea\u6211\u66f4\u65b0<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><strong>\u75c5\u7406\u5173\u8054\u4e0e\u6838\u5fc3\u4fdd\u62a4\u673a\u5236\uff1a\u795e\u7ecf\u8282\u82f7\u8102\uff08\u5c24\u5176GM1\uff09\u7f3a\u5931\u662fPD\u91cd\u8981\u75c5\u7406\u7279\u5f81\uff0c\u5176\u4fdd\u62a4\u4f5c\u7528\u901a\u8fc7\u53cc\u91cd\u901a\u8def\u5b9e\u73b0\uff1a<\/strong><\/p>\n<ul class=\"wp-block-list\">\n<li><strong>\u6297\u03b1-\u7a81\u89e6\u6838\u86cb\u767d\u6bd2\u6027<\/strong>\uff1aGM1\u6291\u5236aSyn\u75c5\u7406\u6027\u805a\u96c6\uff0c\u589e\u5f3aGDNF\u4fe1\u53f7\u901a\u8def\uff1b<\/li>\n<li><strong>\u7ef4\u6301\u5e72\u7ec6\u80de\u7a33\u6001<\/strong>\uff1aGD3\u4f5c\u4e3a\u9759\u606f\u6001NSC\u6c60\u7684\u201d\u770b\u95e8\u5206\u5b50\u201d\uff0c\u9632\u6b62\u8fc7\u5ea6\u8017\u7aed\u3002\u4e34\u5e8a\u8bc1\u636e\u663e\u793aPD\u60a3\u8005\u8111\u5185GM1\u6c34\u5e73\u663e\u8457\u4e0b\u964d\uff0c\u63d0\u793a\u5176\u53ef\u4f5c\u4e3a\u75be\u75c5\u8fdb\u5c55\u7684\u751f\u7269\u6807\u5fd7\u7269\u3002<\/li>\n<\/ul>\n<p>\u9f3b\u8154\u7ed9\u836f\u7814\u7a76\u63ed\u793a\u4e24\u7c7b\u795e\u7ecf\u8282\u82f7\u8102\u7684\u4e92\u8865\u529f\u80fd\uff1a<\/p>\n<ul class=\"wp-block-list\">\n<li><strong>GD3\u9776\u5411\u589e\u6b96<\/strong>\uff1a\u6fc0\u6d3bSVZ\u533aNSC\u81ea\u6211\u66f4\u65b0\uff08BrdU+\/Sox2+\u2191\uff09\uff0c\u4f46\u65e0\u6cd5\u9a71\u52a8\u795e\u7ecf\u5143\u6210\u719f\uff08\u55c5\u7403Th+\u65e0\u589e\u52a0\uff09\uff1b<\/li>\n<li><strong>GM1\u9776\u5411\u5206\u5316<\/strong>\uff1a\u901a\u8fc7\u6838\u8f6c\u5f55\u56e0\u5b50Nurr1\u76f4\u63a5\u8c03\u63a7Th\u57fa\u56e0\u8868\u8fbe\uff0c\u751f\u6210\u529f\u80fd\u6027\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u3002<\/li>\n<\/ul>\n<p>GD3\u4e0eGM1\u4e92\u8865\uff1a<\/p>\n<figure class=\"wp-block-table is-style-stripes\">\n<table class=\"has-fixed-layout\">\n<thead>\n<tr>\n<th>\u7c7b\u578b<\/th>\n<th>\u7ed9\u836f\u65b9\u5f0f<\/th>\n<th>\u529f\u80fd<\/th>\n<th>\u673a\u5236<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>GD3<\/td>\n<td>\u9f3b\u7ed9\u836f<\/td>\n<td>\u6fc0\u6d3bSVZ-NSC\u589e\u6b96<\/td>\n<td>\u6291\u5236p21\u7ec6\u80de\u5468\u671f\u6291\u5236\u5242<\/td>\n<\/tr>\n<tr>\n<td>GM1<\/td>\n<td>\u9f3b\u7ed9\u836f<\/td>\n<td>\u751f\u6210\u529f\u80fd\u6027\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143<\/td>\n<td>\u6fc0\u6d3bNurr1\u8c03\u63a7Th\u8868\u8fbe<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/figure>\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\"><p>\u7a81\u7834\u65b9\u5411\uff1aGD3\u2192GM1\u5e8f\u8d2f\u6cbb\u7597\u6216\u53ef\u540c\u65f6\u5b9e\u73b0\u201d\u6269\u589eNSC\u6c60\u201d\u4e0e\u201d\u5b9a\u5411\u5206\u5316\u4e3a\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u201d\uff0c\u4e3a\u795e\u7ecf\u518d\u751f\u7597\u6cd5\u63d0\u4f9b\u65b0\u8303\u5f0f\u3002<\/p><\/blockquote>\n<h3 id=\"h-\u4e09-\u5916\u6e90\u6027\u795e\u7ecf\u5e72\u7ec6\u80de\u79fb\u690d\" class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E4%B8%89%E3%80%81%E5%A4%96%E6%BA%90%E6%80%A7%E7%A5%9E%E7%BB%8F%E5%B9%B2%E7%BB%86%E8%83%9E%E7%A7%BB%E6%A4%8D\"><\/span><strong>\u4e09\u3001\u5916\u6e90\u6027<span class=\"xintheme_tag_link\">neural stem cell transplantation<\/span><\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u795e\u7ecf\u5e72\u7ec6\u80de\u79fb\u690d\u4f5c\u4e3a\u4fc3\u8fdb\u5e15\u91d1\u68ee\u75c5\u795e\u7ecf\u53d1\u751f\u7684\u5173\u952e\u7b56\u7565\uff0c\u901a\u8fc7\u76f4\u63a5\u8865\u5145\u4e22\u5931\u7684\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u5b9e\u73b0\u529f\u80fd\u4fee\u590d\u3002\u5176\u6838\u5fc3\u7a81\u7834\u5728\u4e8e\uff1a<\/p>\n<ul class=\"wp-block-list\">\n<li><strong>\u7ec6\u80de\u6765\u6e90\u9769\u65b0<\/strong>\u2014\u2014\u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de\uff08iPSCs\uff09\u7ecf\u91cd\u7f16\u7a0b\u6280\u672f\u89c4\u907f\u4f26\u7406\u9650\u5236\uff0c\u5206\u5316\u4e3a\u4e2d\u8111\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\uff08A9\u4e9a\u578b\uff09\uff0c\u79fb\u690d\u540e\u5b58\u6d3b\u7387\u8d8570%\u3002<\/li>\n<li><strong>\u7cbe\u51c6\u5206\u5316\u63a7\u5236<\/strong>\u2014\u2014\u6fc0\u6d3bWnt\u901a\u8def\u8bf1\u5bfc\u8f6c\u5f55\u56e0\u5b50LMX1A\u8868\u8fbe\uff0c\u786e\u4fdd\u795e\u7ecf\u5143\u5177\u8fd0\u52a8\u8c03\u63a7\u529f\u80fd\uff08\u4e0e\u55c5\u7403\u795e\u7ecf\u5143\u533a\u5206\uff09\uff1b<\/li>\n<li>\u7ed3\u6784\u529f\u80fd\u91cd\u5efa\u2014\u2014\u79fb\u690d5\u4e2a\u6708\u540e\uff0c\u4eba\u6e90\u795e\u7ecf\u5143\u4e0e\u5bbf\u4e3b\u7eb9\u72b6\u4f53\u4e2d\u578b\u68d8\u795e\u7ecf\u5143\u5f62\u6210\u529f\u80fd\u6027\u7a81\u89e6\uff0c\u6539\u5584\u8fd0\u52a8\u75c7\u72b6\u3002<\/li>\n<li><strong>\u73b0\u5b58\u6311\u6218<\/strong>\uff1a\u79fb\u690d\u795e\u7ecf\u5143\u53ef\u80fd\u53d7\u5bbf\u4e3b\u03b1-\u7a81\u89e6\u6838\u86cb\u767d\u75c5\u7406\u4fb5\u88ad\u51fa\u73b0\u8def\u6613\u5c0f\u4f53\uff0c\u9700\u8054\u5408\u6297\u75c5\u7406\u7b56\u7565\uff08\u5982\u03b1-syn\u6e05\u9664\uff09\u5f62\u6210\u201c\u7ec6\u80de\u66ff\u4ee3-\u75c5\u7406\u963b\u65ad\u201d\u53cc\u8f68\u7597\u6cd5\u4ee5\u5b9e\u73b0\u957f\u671f\u7597\u6548\u3002<\/li>\n<\/ul>\n<h2 id=\"h-\u672a\u6765\u65b9\u5411\"><span class=\"ez-toc-section\" id=\"%E6%9C%AA%E6%9D%A5%E6%96%B9%E5%90%91\"><\/span>\u672a\u6765\u65b9\u5411<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>\u6709\u8bc1\u636e\u652f\u6301<strong>\u5185\u6e90\u6027\u795e\u7ecf\u5e72\u7ec6\u80de\u548c\u591a\u80fd\u5e72\u7ec6\u80de\u884d\u751f\u795e\u7ecf\u5143\u7684\u518d\u751f\u6f5c\u529b\u3002\u8fd9\u4e24\u79cd\u5e72\u7ec6\u80de\u90fd\u662f\u503c\u5f97\u7814\u7a76\u7684\u5e72\u7ec6\u80de\u6765\u6e90\uff0c\u56e0\u4e3a\u7ec6\u80de\u79fb\u690d\u662f\u6cbb\u7597\u5c40\u90e8\u635f\u4f24\u7684\u53ef\u884c\u65b9\u6cd5<\/strong>\u3002\u4f8b\u5982\u8001\u5e74\u75f4\u5446\u75c7\u7684\u9ed1\u8d28\u3002\u7136\u800c\uff0c\u5bf9\u4e8e\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7b49\u795e\u7ecf\u5143\u7f3a\u5931\u66f4\u4e3a\u5f25\u6f2b\u7684\u75be\u75c5\uff0c\u751a\u81f3\u662f\u5927\u8111\u76ae\u5c42\u4e59\u9170\u80c6\u78b1\u80fd\u795e\u7ecf\u5143\u7f3a\u5931\u7684\u5e15\u91d1\u68ee\u75c5\uff0c\u795e\u7ecf\u5143\u79fb\u690d\u662f\u4e0d\u591f\u7684\u3002<\/p>\n<p>\u56e0\u6b64\uff0c\u6211\u4eec\u5e94\u8be5\u5bf9\u8fd9\u4e24\u79cd\u65b9\u6cd5\u8fdb\u884c\u6295\u8d44\uff0c\u4ee5\u786e\u4fdd\u5f00\u53d1\u51fa\u4e00\u79cd\u66f4\u52a0\u4e2a\u6027\u5316\u7684\u65b9\u6cd5\uff0c\u4f7f\u5c40\u90e8\u548c\u5f25\u6f2b\u6027\u8111\u635f\u4f24\u540e\u7684\u4eba\u8111\u518d\u751f\u3002<\/p>\n<p><strong>\u5185\u6e90\u6027\u795e\u7ecf\u5e72\u7ec6\u80de\u7684\u4e34\u5e8a\u8f6c\u5316\u74f6\u9888\uff1a<\/strong>\u4e3a\u4e86\u4f7f\u5185\u6e90\u6027\u795e\u7ecf\u5e72\u7ec6\u80de (NSC) \u6210\u4e3a\u4fc3\u8fdb\u8111\u518d\u751f\u7684\u6709\u6548\u5e72\u7ec6\u80de\u6765\u6e90\uff0c\u6211\u4eec\u9700\u8981\u786e\u5b9a\u4f11\u7720NSC\u88ab\u91cd\u65b0\u6fc0\u6d3b\u7684\u7a0b\u5ea6\u3001\u5b83\u4eec\u4ea7\u751f\u4e0d\u540c\u7c7b\u578b\u795e\u7ecf\u5143\uff08\u5305\u62ec\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\uff09\u7684\u80fd\u529b\uff0c\u4ee5\u53ca\u5b83\u4eec\u5b8c\u5168\u6574\u5408\u5230\u5c40\u90e8\u795e\u7ecf\u7f51\u7edc\u7684\u80fd\u529b\u3002<\/p>\n<p>\u4e8b\u5b9e\u4e0a\uff0c\u672a\u6765\u7684\u7814\u7a76\u9700\u8981\u8bc4\u4f30\u6765\u81ea\u8111\u5ba4\u4e0b\u533a (SVZ) \u7684NSC\u80fd\u5426\u4ea7\u751f\u6b63\u786e\u4e9a\u578b\u7684\u529f\u80fd\u6027\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\uff08\u4f8b\u5982\uff0c\u9ed1\u8d28\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u6216\u55c5\u7403\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\uff09\uff0c\u8fd9\u4e9b\u795e\u7ecf\u5143\u80fd\u5426\u6574\u5408\u5230\u5c40\u90e8\u795e\u7ecf\u7f51\u7edc\u5e76\u957f\u671f\u5b58\u6d3b\u3002<\/p>\n<p><strong>\u4eba\u8111NSCs\u8ba4\u77e5\u5c40\u9650\u4e0e\u6280\u672f\u7a81\u7834\uff1a<\/strong>\u6210\u4eba\u4e0e\u8870\u8001\u4eba\u8111\u5ba4\u4e0b\u533a\uff08SVZ\uff09\u795e\u7ecf\u5e72\u7ec6\u80de\uff08NSCs\uff09\u7684\u7814\u7a76\u53d7\u9650\u4e8e\u4eba\u8111\u7ec4\u7ec7\u7a00\u7f3a\u53ca\u79bb\u4f53\u7814\u7a76\u7684\u6280\u672f\u58c1\u5792\u3002<\/p>\n<p>\u7136\u800c\u65b0\u6280\u672f\u6b63\u4ee5\u7a7a\u524d\u5206\u8fa8\u7387\u89e3\u6790\u4ebaNSCs\uff1a\u5927\u578b\u8054\u5408\u9879\u76ee\u5df2\u7ed8\u5236\u65b0\u751f\u513f\u3001\u5a74\u5e7c\u513f\u3001\u6210\u4eba\u53ca\u8870\u8001\u8111\u7684NSCs\u56fe\u8c31\uff0c\u63ed\u793a\u5176\u5206\u5b50\u6307\u7eb9\u4e0e\u795e\u7ecf\u53d1\u751f\u6f5c\u80fd\u3002\u4eba\u8111\u5355\u7ec6\u80de\u56fe\u8c31\u7684\u5174\u8d77\u8fdb\u4e00\u6b65\u89e3\u6790\u795e\u7ecf\u5143\u4e9a\u578b\u7f51\u7edc\uff0c\u7406\u89e3\u8fd9\u79cd\u591a\u6837\u6027\u5bf9\u518d\u751f\u7597\u6cd5\u81f3\u5173\u91cd\u8981\u3002<\/p>\n<p><strong>\u4eba\u8111\u79fb\u690d\u7814\u7a76\u7684\u7a81\u7834\u4e0e\u8b66\u793a\uff1a<\/strong>\u4eba\u80ce\u4e2d\u8111\u7ec4\u7ec7\u6210\u529f\u79fb\u690d\u81f3\u5e15\u91d1\u68ee\u75c5\u60a3\u8005\u9ed1\u8d28\u6216\u7eb9\u72b6\u4f53\u540e\uff0c\u968f\u8bbf3-24\u5e74\u8bc1\u5b9e\u79fb\u690d\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u957f\u671f\u5b58\u6d3b\u5e76\u91cd\u5efa\u795e\u7ecf\u652f\u914d\u3002\u4f46\u90e8\u5206\u79fb\u690d\u795e\u7ecf\u5143\u51fa\u73b0\u8def\u6613\u5c0f\u4f53\u75c5\u7406\uff0c\u4f34\u968f\u4e34\u5e8a\u75c7\u72b6\u590d\u53d1\uff0c\u8fd9\u5f3a\u8c03\u9700\u540c\u6b65\u6291\u5236\u75c5\u7406\u8fdb\u7a0b\u4e0e\u4fc3\u8fdb\u795e\u7ecf\u518d\u751f\u3002<\/p>\n<p>\u8fd9\u4e9b\u53d1\u73b0\u98a0\u8986\u8ba4\u77e5\uff1a\u8bc1\u660e\u8870\u8001\/\u75c5\u53d8\u8111\u4ecd\u5177\u663e\u8457\u53ef\u5851\u6027\uff0c\u5176\u673a\u5236\u867d\u672a\u660e\u786e\uff0c\u4f46\u4e3a\u5185\u6e90\u6027\u795e\u7ecf\u5e72\u7ec6\u80de\uff08NSCs\uff09\u4fee\u590d\u63d0\u4f9b\u7406\u8bba\u6846\u67b6\u3002\u65b0\u751f\u795e\u7ecf\u5143\u540c\u6837\u53d1\u5c55\u51faPD\u75c5\u7406\uff0c\u8b66\u793a\u5355\u7eaf\u795e\u7ecf\u5143\u66ff\u4ee3\u65e0\u6cd5\u5b9e\u73b0\u957f\u671f\u7597\u6548\u3002<\/p>\n<p><strong>\u672a\u6765\u6cbb\u7597\u8303\u5f0f\u7684\u6839\u672c\u8f6c\u53d8\uff1a<\/strong>\u56e0\u6b64\uff0c<strong>\u8981\u6210\u529f\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\uff0c\u9700\u8981\u91c7\u53d6\u4e00\u79cd\u591a\u7ba1\u9f50\u4e0b\u7684\u65b9\u6cd5\uff0c\u5c06\u523a\u6fc0\u8111\u518d\u751f\u548c\u6539\u5584\u75c5\u60c5\u7684\u7b56\u7565\u7ed3\u5408\u8d77\u6765\uff0c\u4ee5\u9632\u6b62\u65b0\u7684\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u53d1\u5c55\u4e3a\u75be\u75c5\u75c5\u7406\uff0c\u5e76\u963b\u6b62\u75c5\u60c5\u8fdb\u5c55<\/strong>The<\/p>\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\"><p>\u4e3b\u8981\u53c2\u8003\u8d44\u6599\uff1a<\/p>\n<p>[1]https:\/\/www.cell.com\/stem-cell-reports\/fulltext\/S2213-6711(25)00137-7<\/p>\n<p>Disclaimer: This article is intended only to disseminate scientific knowledge and share industry perspectives, and does not constitute any clinical diagnostic advice! The information published by Hangi Stem Cells is not a substitute for the professional advice of a physician or pharmacist. If you have any questions about copyright or other issues, please feel free to contact me.<\/p><\/blockquote>","protected":false},"excerpt":{"rendered":"<p>\u5728\u672c\u7efc\u8ff0\u4e2d\uff0c\u6211\u4eec\u8ba8\u8bba\u4e86\u5e15\u91d1\u68ee\u75c5\u75c5\u7406\u5982\u4f55\u5f71\u54cd\u795e\u7ecf\u5e72\u7ec6\u80de\u7684\u884c\u4e3a\uff0c\u4ee5\u53ca\u76ee\u524d\u4fc3\u8fdb\u5e15\u91d1\u68ee\u75c5\u518d\u751f\u7684\u836f\u7406\u5b66\u7b56\u7565\u3002\u56de\u8f93SVZ\u7684\u795e\u7ecf\u5e72\u7ec6\u80de\u53ef\u4ee5\u4f5c\u4e3a\u8111\u4fee\u590d\u7684\u5e72\u7ec6\u80de\u6765\u6e90\uff0c\u672a\u6765\u7684\u7814\u7a76\u5e94\u8be5\u80fd\u591f\u9610\u660e\u8fd9\u4e9b\u5e72\u7ec6\u80de\u662f\u5426\u6709\u53ef\u80fd\u4ea7\u751f\u529f\u80fd\u6027\u795e\u7ecf\u5143\u7ec6\u80de\u3002<\/p>","protected":false},"author":1,"featured_media":19259,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"image","meta":{"footnotes":""},"categories":[73],"tags":[159,158,165],"_links":{"self":[{"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/posts\/19266"}],"collection":[{"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/comments?post=19266"}],"version-history":[{"count":1,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/posts\/19266\/revisions"}],"predecessor-version":[{"id":19325,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/posts\/19266\/revisions\/19325"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/media\/19259"}],"wp:attachment":[{"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/media?parent=19266"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/categories?post=19266"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/tags?post=19266"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}