{"id":19810,"date":"2025-10-21T16:41:06","date_gmt":"2025-10-21T08:41:06","guid":{"rendered":"https:\/\/www.hjtdsm.cn\/?p=19810"},"modified":"2025-10-21T16:41:06","modified_gmt":"2025-10-21T08:41:06","slug":"%e9%9f%a9%e5%9b%bd%e8%83%9a%e8%83%8e%e5%b9%b2%e7%bb%86%e8%83%9e%e6%b2%bb%e7%96%97%e5%b8%95%e9%87%91%e6%a3%ae%e7%97%85%e6%96%b0%e7%aa%81%e7%a0%b4%ef%bc%8c12%e4%b8%aa%e6%9c%88%e5%90%8e%e8%bf%90%e5%8a%a8","status":"publish","type":"post","link":"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/19810.html","title":{"rendered":"\u97e9\u56fd\u80da\u80ce\u5e72\u7ec6\u80de\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\u65b0\u7a81\u7834\uff0c12\u4e2a\u6708\u540e\u8fd0\u52a8\u75c7\u72b6\u663e\u8457\u6539\u5584\uff0c\u4e14\u9ad8\u5242\u91cf\u7597\u6548\u66f4\u4f73"},"content":{"rendered":"<section data-role=\"list\">\u5e15\u91d1\u68ee\u75c5 (PD) \u957f\u671f\u4ee5\u6765\u88ab\u8ba4\u4e3a\u662f\u7ec6\u80de\u66ff\u4ee3\u7597\u6cd5\u7684\u7406\u60f3\u5019\u9009\u5bf9\u8c61\u3002\u8fd1\u65e5\uff0c\u9ad8\u4e3d\u5927\u5b66\u5b89\u5ca9\u533b\u9662\u8054\u5408\u5ef6\u4e16\u5927\u5b66\u7b49\u5355\u4f4d\u5728\u300aCell\u300b\u53d1\u8868\u4e86\u4e00\u9879\u7a81\u7834\u6027\u7814\u7a76\u663e\u793a\uff1a\u5229\u7528\u80da\u80ce\u5e72\u7ec6\u80de\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\u65b0\u7a81\u7834\uff0c<a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(25)01041-4\" target=\"_blank\" rel=\"noopener nofollow\">\u4eba\u7c7b\u80da\u80ce\u5e72\u7ec6\u80de\u751f\u6210\u4e86\u9ad8\u7eaf\u5ea6\u591a\u5df4\u80fa\u80fd\u7956\u7ec6\u80de (A9-DPC)\u5b8c\u6210\u4e86\u9488\u5bf9\u5e15\u91d1\u68ee\u75c5\u60a3\u8005\u76841\/2a\u671f\u4e34\u5e8a\u8bd5\u9a8c<\/a>[1]\u3002<\/p>\n<section><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-19815 aligncenter\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/wechat_2025-10-21_123421_118.png\" alt=\"\" width=\"1088\" height=\"398\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/wechat_2025-10-21_123421_118.png 1088w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/wechat_2025-10-21_123421_118-300x110.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/wechat_2025-10-21_123421_118-1024x375.png 1024w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/wechat_2025-10-21_123421_118-768x281.png 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/wechat_2025-10-21_123421_118-18x7.png 18w\" sizes=\"(max-width: 1088px) 100vw, 1088px\" \/><\/section>\n<p>\u7ed3\u679c\u8868\u660e\uff0cA9-DPC\u79fb\u690d12\u4e2a\u6708\u540e\uff0c\u505c\u836f\u540e\u8fd0\u52a8\u969c\u788d\u534f\u4f1a\u7edf\u4e00\u5e15\u91d1\u68ee\u75c5\u8bc4\u5b9a\u91cf\u8868 (MDS-UPDRS) III\u90e8\u5206\u8bc4\u5206\u548cHoehn\u548cYahr\u5206\u671f\u5747\u6709\u6240\u6539\u5584\uff0c\u4e14\u9ad8\u5242\u91cf\u7ec4\u7684\u8fd0\u52a8\u529f\u80fd\u6539\u5584\u66f4\u663e\u8457\u3002\u6b64\u5916\uff0c\u591a\u5df4\u80fa\u8f6c\u8fd0\u4f53\u7ecf\u8fc7\u6b63\u7535\u5b50\u53d1\u5c04\u65ad\u5c42\u626b\u63cf (PET) \u6210\u50cf\u663e\u793a\u79fb\u690d\u540e\u58f3\u6838\u6444\u53d6\u589e\u52a0\uff0c\u4e14\u9ad8\u5242\u91cf\u7ec4\u7684\u6444\u53d6\u91cf\u66f4\u9ad8\uff0c\u652f\u6301\u79fb\u690d\u7269\u5b58\u6d3b\u3002\u8fd9\u4e9b\u7ed3\u679c\u8868\u660e\u53cc\u4fa7A9-DPC\u79fb\u690d\u662f\u5b89\u5168\u7684\uff0c\u5e76\u53ef\u80fd\u6539\u5584\u5e15\u91d1\u68ee\u75c5\u60a3\u8005\u7684<span class=\"\">\u5e15\u91d1\u68ee\u75c5\u8fd0\u52a8\u75c7\u72b6<\/span>The<\/p>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_79_2 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewbox=\"0 0 24 24\" version=\"1.2\" baseprofile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/19810.html\/#%E5%B8%95%E9%87%91%E6%A3%AE%E7%97%85%E7%9A%84%E6%A0%B8%E5%BF%83%E9%97%AE%E9%A2%98%E4%B8%8E%E5%BD%93%E5%89%8D%E6%B2%BB%E7%96%97%E5%B1%80%E9%99%90\" >\u5e15\u91d1\u68ee\u75c5\u7684\u6838\u5fc3\u95ee\u9898\u4e0e\u5f53\u524d\u6cbb\u7597\u5c40\u9650<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/19810.html\/#%E7%A0%B4%E5%B1%80%E4%B9%8B%E9%81%93%EF%BC%9A%E7%BB%86%E8%83%9E%E6%9B%BF%E4%BB%A3%E7%96%97%E6%B3%95%E4%B8%8E%E8%83%9A%E8%83%8E%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E5%B8%95%E9%87%91%E6%A3%AE%E7%97%85%E7%9A%84%E6%BD%9C%E5%8A%9B\" >\u7834\u5c40\u4e4b\u9053\uff1a\u7ec6\u80de\u66ff\u4ee3\u7597\u6cd5\u4e0e\u80da\u80ce\u5e72\u7ec6\u80de\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\u7684\u6f5c\u529b<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/19810.html\/#%E6%A0%B8%E5%BF%83%E6%8A%80%E6%9C%AF%EF%BC%9AA9-DPC%E7%9A%84%E6%A0%87%E5%87%86%E5%8C%96%E5%88%B6%E9%80%A0%E6%B5%81%E7%A8%8B\" >\u6838\u5fc3\u6280\u672f\uff1aA9-DPC\u7684\u6807\u51c6\u5316\u5236\u9020\u6d41\u7a0b<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/19810.html\/#A9-DPC%E6%B2%BB%E7%96%97%E5%B8%95%E9%87%91%E6%A3%AE%E7%97%85%E7%9A%84%E9%A6%96%E6%AC%A1%E4%BA%BA%E4%BD%93%E8%AF%95%E9%AA%8C%EF%BC%9A%E6%82%A3%E8%80%85%E6%8B%9B%E5%8B%9F%E4%B8%8E%E8%AF%95%E9%AA%8C%E6%B5%81%E7%A8%8B\" >A9-DPC\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\u7684\u9996\u6b21\u4eba\u4f53\u8bd5\u9a8c\uff1a\u60a3\u8005\u62db\u52df\u4e0e\u8bd5\u9a8c\u6d41\u7a0b<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/19810.html\/#%E6%A0%B8%E5%BF%83%E6%88%90%E6%9E%9C%EF%BC%9A%E8%83%9A%E8%83%8E%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E5%B8%95%E9%87%91%E6%A3%AE%E7%97%85%E7%9A%84%E5%AE%89%E5%85%A8%E6%80%A7%E4%B8%8E%E6%9C%89%E6%95%88%E6%80%A7%E5%AE%9E%E7%8E%B0%E5%8F%8C%E7%AA%81%E7%A0%B4\" >\u6838\u5fc3\u6210\u679c\uff1a\u80da\u80ce\u5e72\u7ec6\u80de\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\u7684\u5b89\u5168\u6027\u4e0e\u6709\u6548\u6027\u5b9e\u73b0\u53cc\u7a81\u7834<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/19810.html\/#1%E3%80%81%E5%AE%89%E5%85%A8%E6%80%A7%EF%BC%9A%E6%97%A0%E4%B8%A5%E9%87%8D%E4%B8%8D%E8%89%AF%E5%8F%8D%E5%BA%94%EF%BC%8C%E7%BB%86%E8%83%9E%E7%9B%B8%E5%85%B3%E9%A3%8E%E9%99%A9%E4%B8%BA%E9%9B%B6\" >1\u3001\u5b89\u5168\u6027\uff1a\u65e0\u4e25\u91cd\u4e0d\u826f\u53cd\u5e94\uff0c\u7ec6\u80de\u76f8\u5173\u98ce\u9669\u4e3a\u96f6<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/19810.html\/#2%E3%80%81%E6%9C%89%E6%95%88%E6%80%A7%EF%BC%9A%E8%BF%90%E5%8A%A8%E7%97%87%E7%8A%B6%E6%98%BE%E8%91%97%E6%94%B9%E5%96%84%EF%BC%8C%E5%89%82%E9%87%8F%E4%BE%9D%E8%B5%96%E6%80%A7%E6%98%8E%E6%98%BE\" >2\u3001\u6709\u6548\u6027\uff1a\u8fd0\u52a8\u75c7\u72b6\u663e\u8457\u6539\u5584\uff0c\u5242\u91cf\u4f9d\u8d56\u6027\u660e\u663e<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/19810.html\/#%E5%85%B3%E9%94%AE%E8%AF%81%E6%8D%AE%EF%BC%9A%E5%BD%B1%E5%83%8F%E5%AD%A6%E8%AF%81%E5%AE%9E%E7%BB%86%E8%83%9E%E5%AD%98%E6%B4%BB%E3%80%81%E6%95%B4%E5%90%88%E4%B8%8E%E5%8A%9F%E8%83%BD%E5%85%B3%E8%81%94\" >\u5173\u952e\u8bc1\u636e\uff1a\u5f71\u50cf\u5b66\u8bc1\u5b9e\u7ec6\u80de\u5b58\u6d3b\u3001\u6574\u5408\u4e0e\u529f\u80fd\u5173\u8054<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/19810.html\/#%E7%A0%94%E7%A9%B6%E6%84%8F%E4%B9%89%E4%B8%8E%E5%B1%95%E6%9C%9B%EF%BC%9A%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E5%B8%95%E9%87%91%E6%A3%AE%E7%97%85%E7%9A%84%E9%87%8C%E7%A8%8B%E7%A2%91\" >\u7814\u7a76\u610f\u4e49\u4e0e\u5c55\u671b\uff1a\u5e72\u7ec6\u80de\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\u7684\u91cc\u7a0b\u7891<\/a><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"%E5%B8%95%E9%87%91%E6%A3%AE%E7%97%85%E7%9A%84%E6%A0%B8%E5%BF%83%E9%97%AE%E9%A2%98%E4%B8%8E%E5%BD%93%E5%89%8D%E6%B2%BB%E7%96%97%E5%B1%80%E9%99%90\"><\/span><strong>\u5e15\u91d1\u68ee\u75c5\u7684\u6838\u5fc3\u95ee\u9898\u4e0e\u5f53\u524d\u6cbb\u7597\u5c40\u9650<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><a href=\"https:\/\/www.hjtdsm.cn\/en\/research\/ns\/pd\/19756.html\/\" target=\"_blank\" rel=\"noopener\">Parkinson's disease<\/a>\u662f\u4e00\u79cd\u8fdb\u884c\u6027<a href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/nsc\/19258.html\/\" target=\"_blank\" rel=\"noopener\">neurodegenerative disease<\/a>\uff0c\u5176\u6838\u5fc3\u75c5\u7406\u7279\u5f81\u662f\u5927\u8111\u9ed1\u8d28\u533a\u7279\u5b9a\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u7684\u9009\u62e9\u6027\u3001\u4e0d\u53ef\u9006\u4e27\u5931\uff0c\u5bfc\u81f4\u8c03\u63a7\u8fd0\u52a8\u7684\u5173\u952e\u533a\u57df\u2014\u2014\u7eb9\u72b6\u4f53\u51fa\u73b0\u591a\u5df4\u80fa\u4e25\u91cd\u8017\u7aed\uff0c\u4ece\u800c\u5f15\u53d1\u9707\u98a4\u3001\u50f5\u76f4\u548c\u8fd0\u52a8\u8fdf\u7f13\u7b49\u5178\u578b\u8fd0\u52a8\u75c7\u72b6\u3002<\/p>\n<section><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-19822 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/istockphoto-1605413317-612x612-1.jpg\" alt=\"\u97e9\u56fd\u80da\u80ce\u5e72\u7ec6\u80de\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\u65b0\u7a81\u7834\uff0c12\u4e2a\u6708\u540e\u8fd0\u52a8\u75c7\u72b6\u663e\u8457\u6539\u5584\uff0c\u4e14\u9ad8\u5242\u91cf\u7597\u6548\u66f4\u4f73\" width=\"612\" height=\"408\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/istockphoto-1605413317-612x612-1.jpg 612w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/istockphoto-1605413317-612x612-1-300x200.jpg 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/istockphoto-1605413317-612x612-1-18x12.jpg 18w\" sizes=\"(max-width: 612px) 100vw, 612px\" \/><\/section>\n<p>\u73b0\u6709\u7684\u6807\u51c6\u7597\u6cd5\uff0c\u5982\u836f\u7269\u6cbb\u7597\u548c\u8111\u6df1\u90e8\u7535\u523a\u6fc0\uff0c\u4e3b\u8981\u901a\u8fc7\u5916\u6e90\u6027\u8865\u5145\u591a\u5df4\u80fa\u6216\u8c03\u8282\u795e\u7ecf\u56de\u8def\u6765\u7f13\u89e3\u75c7\u72b6\uff0c\u4f46\u5b83\u4eec\u90fd\u65e0\u6cd5\u963b\u6b62\u6216\u9006\u8f6c\u591a\u5df4\u80fa\u795e\u7ecf\u5143\u7684\u6301\u7eed\u6b7b\u4ea1\uff0c\u5c5e\u4e8e\u6cbb\u6807\u4e0d\u6cbb\u672c\u7684\u5bf9\u75c7\u5904\u7406\uff0c\u4e14\u957f\u671f\u5e94\u7528\u5e38\u4f34\u968f\u7597\u6548\u6ce2\u52a8\u548c\u8fd0\u52a8\u5e76\u53d1\u75c7\u3002<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%E7%A0%B4%E5%B1%80%E4%B9%8B%E9%81%93%EF%BC%9A%E7%BB%86%E8%83%9E%E6%9B%BF%E4%BB%A3%E7%96%97%E6%B3%95%E4%B8%8E%E8%83%9A%E8%83%8E%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E5%B8%95%E9%87%91%E6%A3%AE%E7%97%85%E7%9A%84%E6%BD%9C%E5%8A%9B\"><\/span><strong>\u7834\u5c40\u4e4b\u9053\uff1a\u7ec6\u80de\u66ff\u4ee3\u7597\u6cd5\u4e0e\u80da\u80ce\u5e72\u7ec6\u80de\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\u7684\u6f5c\u529b<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>\u9762\u5bf9\u8fd9\u4e00\u56f0\u5c40\uff0c\u57fa\u4e8e\u201c\u7ec6\u80de\u66ff\u4ee3\u201d\u601d\u8def\u7684\u6cbb\u7597\u7b56\u7565\u5e94\u8fd0\u800c\u751f\u3002\u8be5\u7597\u6cd5\u65e8\u5728\u901a\u8fc7\u79fb\u690d\u5065\u5eb7\u7ec6\u80de\uff0c\u76f4\u63a5\u201c\u66ff\u6362\u201d\u5df2\u6b7b\u4ea1\u7684\u795e\u7ecf\u5143\uff0c\u4ece\u6839\u6e90\u4e0a\u4fee\u590d\u795e\u7ecf\u73af\u8def\u3002\u65e9\u671f\u7684\u80ce\u513f\u7ec4\u7ec7\u79fb\u690d\u867d\u9a8c\u8bc1\u4e86\u8fd9\u4e00\u6982\u5ff5\u7684\u53ef\u884c\u6027\uff0c\u5374\u53d7\u56f0\u4e8e\u4f26\u7406\u4e89\u8bae\u3001\u6765\u6e90\u7a00\u7f3a\u53ca\u7ec6\u80de\u5f02\u8d28\u6027\u7b49\u74f6\u9888\u3002<\/p>\n<p>\u4eba\u591a\u80fd\u5e72\u7ec6\u80de\uff0c\u5c24\u5176\u662f<span 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id=\"%E6%A0%B8%E5%BF%83%E6%8A%80%E6%9C%AF%EF%BC%9AA9-DPC%E7%9A%84%E6%A0%87%E5%87%86%E5%8C%96%E5%88%B6%E9%80%A0%E6%B5%81%E7%A8%8B\"><\/span><strong>\u6838\u5fc3\u6280\u672f\uff1aA9-DPC\u7684\u6807\u51c6\u5316\u5236\u9020\u6d41\u7a0b<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>A9-DPC\u7684\u5236\u9020\u59cb\u4e8e\u4e34\u5e8a\u7ea7hESC\u7cfb\uff08SNU-hES32\uff09\u3002\u5728\u4e25\u683c\u7684\u836f\u54c1\u751f\u4ea7\u8d28\u91cf\u7ba1\u7406\u89c4\u8303\uff08GMP\uff09\u6761\u4ef6\u4e0b\uff0c\u901a\u8fc7\u4e00\u4e2a\u6210\u5206\u660e\u786e\u3001\u4ec5\u4f7f\u7528\u5c0f\u5206\u5b50\u7684\u6807\u51c6\u5316\u65b9\u6848\uff0c\u5c06\u5e72\u7ec6\u80de\u5b9a\u5411\u8bf1\u5bfc\u5206\u5316\u4e3a\u4e2d\u8111\u591a\u5df4\u80fa\u80fd\u7956\u7ec6\u80de\uff08mDA\uff09\u3002<\/p>\n<section><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-19825 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/\u5fae\u4fe1\u56fe\u7247_2025-10-21_124442_094.png\" alt=\"\u56fe1\uff1aA9-DPC\u5236\u5907\u793a\u610f\u56fe\" width=\"3321\" height=\"2059\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/\u5fae\u4fe1\u56fe\u7247_2025-10-21_124442_094.png 3321w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/\u5fae\u4fe1\u56fe\u7247_2025-10-21_124442_094-300x186.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/\u5fae\u4fe1\u56fe\u7247_2025-10-21_124442_094-1024x635.png 1024w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/\u5fae\u4fe1\u56fe\u7247_2025-10-21_124442_094-768x476.png 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/\u5fae\u4fe1\u56fe\u7247_2025-10-21_124442_094-1536x952.png 1536w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/\u5fae\u4fe1\u56fe\u7247_2025-10-21_124442_094-2048x1270.png 2048w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/\u5fae\u4fe1\u56fe\u7247_2025-10-21_124442_094-18x12.png 18w\" sizes=\"(max-width: 3321px) 100vw, 3321px\" 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id=\"A9-DPC%E6%B2%BB%E7%96%97%E5%B8%95%E9%87%91%E6%A3%AE%E7%97%85%E7%9A%84%E9%A6%96%E6%AC%A1%E4%BA%BA%E4%BD%93%E8%AF%95%E9%AA%8C%EF%BC%9A%E6%82%A3%E8%80%85%E6%8B%9B%E5%8B%9F%E4%B8%8E%E8%AF%95%E9%AA%8C%E6%B5%81%E7%A8%8B\"><\/span><strong>A9-DPC\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\u7684\u9996\u6b21\u4eba\u4f53\u8bd5\u9a8c\uff1a\u60a3\u8005\u62db\u52df\u4e0e\u8bd5\u9a8c\u6d41\u7a0b<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>\u8fd9\u98791\/2a\u671f\u8bd5\u9a8c\u5171\u62db\u52df\u4e8612\u540d\u4e2d\u81f3\u91cd\u5ea6\u5e15\u91d1\u68ee\u75c5\u60a3\u8005\u3002\u53c2\u4e0e\u8005\u88ab\u5e73\u5747\u5206\u4e3a\u4e24\u7ec4\uff1a\u4f4e\u5242\u91cf\u7ec4\uff08315\u4e07\u4e2a\u7ec6\u80de\uff0cn=6\uff09\u548c\u9ad8\u5242\u91cf\u7ec4\uff08630\u4e07\u4e2a\u7ec6\u80de\uff0cn=6\uff09\u3002\u6240\u6709\u53c2\u4e0e\u8005\u7684\u5e73\u5747\u5e74\u9f84\u4e3a60.3\u5c81\uff0c\u5e73\u5747\u75c5\u7a0b\u8fbe10.5\u5e74\uff0c\u786e\u4fdd\u4e86\u7814\u7a76\u4eba\u7fa4\u5177\u6709\u4ee3\u8868\u6027\u4e14\u57fa\u7ebf\u7279\u5f81\u76f8\u4f3c\u3002<\/p>\n<section><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-19824 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/\u5fae\u4fe1\u56fe\u7247_2025-10-21_124629_812.png\" alt=\"\u56fe2\uff1a\u8bd5\u9a8c\u8bbe\u8ba1\" width=\"3321\" height=\"1920\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/\u5fae\u4fe1\u56fe\u7247_2025-10-21_124629_812.png 3321w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/\u5fae\u4fe1\u56fe\u7247_2025-10-21_124629_812-300x173.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/\u5fae\u4fe1\u56fe\u7247_2025-10-21_124629_812-1024x592.png 1024w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/\u5fae\u4fe1\u56fe\u7247_2025-10-21_124629_812-768x444.png 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/\u5fae\u4fe1\u56fe\u7247_2025-10-21_124629_812-1536x888.png 1536w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/\u5fae\u4fe1\u56fe\u7247_2025-10-21_124629_812-2048x1184.png 2048w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/\u5fae\u4fe1\u56fe\u7247_2025-10-21_124629_812-18x10.png 18w\" sizes=\"(max-width: 3321px) 100vw, 3321px\" 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class=\"ez-toc-section\" id=\"%E6%A0%B8%E5%BF%83%E6%88%90%E6%9E%9C%EF%BC%9A%E8%83%9A%E8%83%8E%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E5%B8%95%E9%87%91%E6%A3%AE%E7%97%85%E7%9A%84%E5%AE%89%E5%85%A8%E6%80%A7%E4%B8%8E%E6%9C%89%E6%95%88%E6%80%A7%E5%AE%9E%E7%8E%B0%E5%8F%8C%E7%AA%81%E7%A0%B4\"><\/span><strong>\u6838\u5fc3\u6210\u679c\uff1a\u80da\u80ce\u5e72\u7ec6\u80de\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\u7684\u5b89\u5168\u6027\u4e0e\u6709\u6548\u6027\u5b9e\u73b0\u53cc\u7a81\u7834<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<h3><span class=\"ez-toc-section\" id=\"1%E3%80%81%E5%AE%89%E5%85%A8%E6%80%A7%EF%BC%9A%E6%97%A0%E4%B8%A5%E9%87%8D%E4%B8%8D%E8%89%AF%E5%8F%8D%E5%BA%94%EF%BC%8C%E7%BB%86%E8%83%9E%E7%9B%B8%E5%85%B3%E9%A3%8E%E9%99%A9%E4%B8%BA%E9%9B%B6\"><\/span><strong>1\u3001\u5b89\u5168\u6027\uff1a\u65e0\u4e25\u91cd\u4e0d\u826f\u53cd\u5e94\uff0c\u7ec6\u80de\u76f8\u5173\u98ce\u9669\u4e3a\u96f6<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u572812\u4e2a\u6708\u7684\u968f\u8bbf\u671f\u5185\uff0cA9-DPC\u79fb\u690d\u8868\u73b0\u51fa\u4f18\u5f02\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u3002\u5171\u8bb0\u5f55\u768432\u8d77\u4e0d\u826f\u4e8b\u4ef6\u5747\u88ab\u8bc4\u4f30\u4e0e\u7ec6\u80de\u4ea7\u54c1\u672c\u8eab\u7edd\u5bf9\u65e0\u5173\u3002\u5176\u4e2d\uff0c\u4ec51\u8d77\u4e3a\u624b\u672f\u76f8\u5173\u7684\u65e0\u75c7\u72b6\u9885\u5185\u51fa\u8840\uff1b\u53e6\u67093\u8d77\u4e8b\u4ef6\uff08\u6d89\u53ca2\u540d\u60a3\u8005\uff09\u88ab\u8ba4\u4e3a\u53ef\u80fd\u4e0e\u514d\u75ab\u6291\u5236\u5242\u6709\u5173\uff0c\u5305\u62ec\u4e00\u8fc7\u6027\u9ad8\u94be\u8840\u75c7\u548c\u65b0\u53d1\u7cd6\u5c3f\u75c5\uff0c\u8fd9\u4e9b\u60c5\u51b5\u5747\u5f97\u5230\u6709\u6548\u7ba1\u7406\u3002\u552f\u4e00\u88ab\u62a5\u544a\u7684\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\u662f\u4e00\u540d\u60a3\u8005\u7684\u65e0\u75c7\u72b6\u8840\u5c0f\u677f\u51cf\u5c11\uff0c\u8be5\u4e8b\u4ef6\u5bfc\u81f4\u4f4f\u9662\u65f6\u95f4\u5ef6\u957f\u4e00\u5929\uff0c\u4f46\u672a\u8fdb\u884c\u7279\u6b8a\u5e72\u9884\u5373\u81ea\u884c\u7f13\u89e3\u3002<\/p>\n<p>\u603b\u4f53\u800c\u8a00\uff0c\u6240\u670912\u540d\u60a3\u8005\u4e2d\u4ec5\u51fa\u73b01\u4f8b\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\uff0c\u4e14\u672a\u786e\u5b9a\u5176\u786e\u5207\u75c5\u56e0\u3002\u6700\u91cd\u8981\u7684\u662f\uff0c\u5728\u6574\u4e2a\u89c2\u5bdf\u671f\u5185\uff0c\u6ca1\u6709\u4efb\u4f55\u60a3\u8005\u51fa\u73b0\u80bf\u7624\u5f62\u6210\u6216\u79fb\u690d\u7269\u5f02\u5e38\u751f\u957f\u7684\u8ff9\u8c61\u3002\u8fd9\u4e9b\u6570\u636e\u5171\u540c\u8868\u660e\uff0cA9-DPC\u7ec6\u80de\u6cbb\u7597\u5728\u5e15\u91d1\u68ee\u75c5\u60a3\u8005\u4e2d\u5177\u6709\u53ef\u9760\u7684\u5b89\u5168\u8f6e\u5ed3\u3002<\/p>\n<h3><span class=\"ez-toc-section\" id=\"2%E3%80%81%E6%9C%89%E6%95%88%E6%80%A7%EF%BC%9A%E8%BF%90%E5%8A%A8%E7%97%87%E7%8A%B6%E6%98%BE%E8%91%97%E6%94%B9%E5%96%84%EF%BC%8C%E5%89%82%E9%87%8F%E4%BE%9D%E8%B5%96%E6%80%A7%E6%98%8E%E6%98%BE\"><\/span><strong>2\u3001\u6709\u6548\u6027\uff1a\u8fd0\u52a8\u75c7\u72b6\u663e\u8457\u6539\u5584\uff0c\u5242\u91cf\u4f9d\u8d56\u6027\u660e\u663e<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u6839\u636e12\u4e2a\u6708\u7684\u968f\u8bbf\u6570\u636e\uff0cA9-DPC\u79fb\u690d\u5728\u5e15\u91d1\u68ee\u75c5\u60a3\u8005\u4e2d\u663e\u793a\u51fa\u660e\u786e\u7684\u63a2\u7d22\u6027\u7597\u6548\u3002\u6700\u6838\u5fc3\u7684\u6539\u5584\u4f53\u73b0\u5728\u60a3\u8005\u7684\u201c\u505c\u836f\u201d\u8fd0\u52a8\u529f\u80fd\u4e0a\uff1a\u6240\u6709\u53c2\u4e0e\u8005\u7684\u4e3b\u8981\u7ec8\u70b9\u6307\u6807\u2014\u2014MDS-UPDRS\u7b2c\u4e09\u90e8\u5206\uff08OFF\uff09\u8bc4\u5206\uff0c\u5e73\u5747\u663e\u8457\u6539\u5584\u4e86<span data-pm-slice=\"0 0 []\">-14.1\u00b16.2\u5206<span dir=\"auto\" data-pm-slice=\"0 0 []\">\uff08\u6539\u5584\uff09\uff08<\/span><span dir=\"auto\">\u8868 S3<\/span><span dir=\"auto\">\uff09<\/span><\/span>The<\/p>\n<p>\u66f4\u91cd\u8981\u7684\u662f\uff0c\u7597\u6548\u5448\u73b0\u51fa\u663e\u8457\u7684\u5242\u91cf\u4f9d\u8d56\u6027\uff0c\u9ad8\u5242\u91cf\u7ec4\u7684\u6539\u5584\u5e45\u5ea6\uff08-15.5\u5206\uff09<span data-pm-slice=\"1 1 [&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;outer&quot;,&quot;label&quot;:&quot;edit by 135editor&quot;,&quot;data-pm-slice&quot;:&quot;0 0 []&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;paragraph&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;list&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;outer&quot;,&quot;label&quot;:&quot;edit by 135editor&quot;,&quot;data-pm-slice&quot;:&quot;0 0 []&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;paragraph&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;list&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;outer&quot;,&quot;label&quot;:&quot;edit by 135editor&quot;,&quot;data-pm-slice&quot;:&quot;0 0 []&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;paragraph&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;list&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;p&quot;,&quot;attributes&quot;:{&quot;style&quot;:&quot;box-sizing: border-box; margin: 16px 0px; padding: 0px; color: rgb(51, 51, 51); font-family: MicrosoftYaHei; font-size: 16px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: 0.5px; orphans: 2; text-align: start; text-indent: 0px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: rgb(248, 249, 249); text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;&quot;,&quot;data-pm-slice&quot;:&quot;0 0 []&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;}]\">\uff08\u6539\u5584\u7387\u7ea626%\uff09<\/span>\u663e\u8457\u5927\u4e8e\u4f4e\u5242\u91cf\u7ec4\uff08-12.7\u5206\uff09<span data-pm-slice=\"1 1 [&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;outer&quot;,&quot;label&quot;:&quot;edit by 135editor&quot;,&quot;data-pm-slice&quot;:&quot;0 0 []&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;paragraph&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;list&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;outer&quot;,&quot;label&quot;:&quot;edit by 135editor&quot;,&quot;data-pm-slice&quot;:&quot;0 0 []&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;paragraph&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;list&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;outer&quot;,&quot;label&quot;:&quot;edit by 135editor&quot;,&quot;data-pm-slice&quot;:&quot;0 0 []&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;paragraph&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;list&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;p&quot;,&quot;attributes&quot;:{&quot;style&quot;:&quot;box-sizing: border-box; margin: 16px 0px; padding: 0px; color: rgb(51, 51, 51); font-family: MicrosoftYaHei; font-size: 16px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: 0.5px; orphans: 2; text-align: start; text-indent: 0px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: rgb(248, 249, 249); text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;&quot;,&quot;data-pm-slice&quot;:&quot;0 0 []&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;}]\">\uff08\u6539\u5584\u7387\u7ea621%\uff09<\/span><span dir=\"auto\" data-pm-slice=\"0 0 []\">\uff08<\/span><span dir=\"auto\">Figure 3<\/span><span dir=\"auto\">A\uff09<\/span>\uff0c\u7edf\u8ba1\u6a21\u578b\u8bc1\u5b9e\u4e86\u9ad8\u5242\u91cf\u7ec4\u968f\u65f6\u95f4\u63a8\u79fb\u6709\u66f4\u5927\u7684\u6539\u5584<span dir=\"auto\" data-pm-slice=\"0 0 []\">\uff08<\/span><span dir=\"auto\">Figure 3<\/span><span dir=\"auto\">B<\/span><span dir=\"auto\">\uff09<\/span>\u3002\u53e6\u4e00\u9879\u5173\u952e\u6307\u6807Hoehn\u548cYahr\u5206\u671f\uff08OFF\uff09\u4e5f\u4e00\u81f4\u5730\u663e\u793a\u51fa\u9ad8\u5242\u91cf\u7ec4\u66f4\u4f18\u7684\u6539\u5584\u6548\u679c<span dir=\"auto\" data-pm-slice=\"0 0 []\">\uff08<\/span><span dir=\"auto\">\u8868S3<\/span><span dir=\"auto\">\uff1b\u56fe<\/span><span dir=\"auto\">3C\uff09<\/span>The<\/p>\n<section><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-19821 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/\u5fae\u4fe1\u56fe\u7247_2025-10-21_155454_819.png\" alt=\"\u56fe3\uff1aA9-DPC\u79fb\u690d\u540e\u4e34\u5e8a\u7ed3\u679c\u7684\u7eb5\u5411\u53d8\u5316\" width=\"3321\" height=\"1590\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/\u5fae\u4fe1\u56fe\u7247_2025-10-21_155454_819.png 3321w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/\u5fae\u4fe1\u56fe\u7247_2025-10-21_155454_819-300x144.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/\u5fae\u4fe1\u56fe\u7247_2025-10-21_155454_819-1024x490.png 1024w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/\u5fae\u4fe1\u56fe\u7247_2025-10-21_155454_819-768x368.png 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/\u5fae\u4fe1\u56fe\u7247_2025-10-21_155454_819-1536x735.png 1536w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/\u5fae\u4fe1\u56fe\u7247_2025-10-21_155454_819-2048x981.png 2048w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/\u5fae\u4fe1\u56fe\u7247_2025-10-21_155454_819-18x9.png 18w\" sizes=\"(max-width: 3321px) 100vw, 3321px\" \/><\/section>\n<p>\u7597\u6548\u8868\u73b0\u5177\u6709\u9ad8\u5ea6\u7279\u5f02\u6027\u3002\u4e0e\u201c\u505c\u836f\u201d\u72b6\u6001\u7684\u663e\u8457\u6539\u5584\u5f62\u6210\u9c9c\u660e\u5bf9\u6bd4\u7684\u662f\uff0c\u60a3\u8005\u5728\u201c\u7528\u836f\u201d\u72b6\u6001\u4e0b\u7684\u8fd0\u52a8\u529f\u80fd\u672a\u89c1\u663e\u8457\u53d8\u5316\u3002<span dir=\"auto\" data-pm-slice=\"0 0 []\">MDS-UPDRS\u7b2c\u4e09\u90e8\u5206 (ON) \u8bc4\u5206\u7684\u5e73\u5747\u00b1SD \u53d8\u5316\u4e3a0\u00b14.6\u5206\uff08<\/span><span dir=\"auto\">\u8868S3<\/span><span dir=\"auto\">\uff09\u3002MDS-UPDRS\u7b2c\u4e09\u90e8\u5206 (ON) \u8bc4\u5206\u7684\u5e73\u5747\u53d8\u5316\u5728\u4f4e\u5242\u91cf\u7ec4\u4e2d\u4e3a-2.8\u00b14.5\u5206\uff0c\u5728\u9ad8\u5242\u91cf\u7ec4\u4e2d\u4e3a2.8\u00b12.6\u5206\uff08<\/span><span dir=\"auto\">\u56feS1<\/span><span dir=\"auto\">A\uff09\u3002\u540c\u6837\uff0c\u5bf9\u4e8eH&amp;Y (ON) \u9636\u6bb5\uff0c\u4e0e\u57fa\u7ebf\u76f8\u6bd4\uff0c12\u4e2a\u6708\u65f6\u4f4e\u5242\u91cf\u7ec4\u4e2d\u7684\u5e73\u5747\u00b1SD \u53d8\u5316\u4e3a-0.2\u00b10.4\u5206\uff0c\u5728\u9ad8\u5242\u91cf\u7ec4\u4e2d\u4e3a-0.2\u00b10.4\u5206\uff08<\/span><span dir=\"auto\">\u8868S3<\/span><span dir=\"auto\">\uff1b<\/span><span dir=\"auto\">\u56feS1<\/span><span dir=\"auto\">B\uff09\u3002<\/span><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-19820 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/\u5fae\u4fe1\u56fe\u7247_2025-10-21_155513_417.png\" alt=\"\u56feS1A9-DPC\u79fb\u690d\u540e\u7528\u836f\u72b6\u6001\u4e0b\u4e34\u5e8a\u7ed3\u679c\u7684\u7eb5\u5411\u53d8\u5316\uff0c\u4e0e\u56fe3\u76f8\u5173\" width=\"3321\" height=\"1822\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/\u5fae\u4fe1\u56fe\u7247_2025-10-21_155513_417.png 3321w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/\u5fae\u4fe1\u56fe\u7247_2025-10-21_155513_417-300x165.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/\u5fae\u4fe1\u56fe\u7247_2025-10-21_155513_417-1024x562.png 1024w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/\u5fae\u4fe1\u56fe\u7247_2025-10-21_155513_417-768x421.png 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/\u5fae\u4fe1\u56fe\u7247_2025-10-21_155513_417-1536x843.png 1536w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/\u5fae\u4fe1\u56fe\u7247_2025-10-21_155513_417-2048x1124.png 2048w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/\u5fae\u4fe1\u56fe\u7247_2025-10-21_155513_417-18x10.png 18w\" sizes=\"(max-width: 3321px) 100vw, 3321px\" \/><\/p>\n<p>\u8fd9\u4e00\u7ed3\u679c\u6070\u597d\u7b26\u5408\u7ec6\u80de\u7597\u6cd5\u7684\u4f5c\u7528\u673a\u5236\u9884\u671f\uff1a\u79fb\u690d\u7684\u7ec6\u80de\u65e8\u5728\u81ea\u8eab\u6301\u7eed\u5206\u6ccc\u591a\u5df4\u80fa\u4ee5\u6539\u5584\u836f\u7269\u5931\u6548\u671f\u7684\u75c7\u72b6\uff0c\u800c\u975e\u8fdb\u4e00\u6b65\u589e\u5f3a\u836f\u7269\u5cf0\u503c\u7684\u6548\u5e94\u3002\u6b64\u5916\uff0c\u7597\u6548\u5177\u6709\u5168\u9762\u6027\uff0c\u60a3\u8005\u7684\u65e5\u5e38\u751f\u6d3b\u6d3b\u52a8\u80fd\u529b\u3001\u975e\u8fd0\u52a8\u75c7\u72b6\u53ca\u751f\u6d3b\u8d28\u91cf\u8bc4\u5206\u5747\u4ece\u57fa\u7ebf\u6c34\u5e73\u83b7\u5f97\u663e\u8457\u63d0\u5347\u3002<\/p>\n<p><span dir=\"auto\">\u56feS2<\/span><span dir=\"auto\">respond in singing<\/span><span dir=\"auto\">\u8868S3<\/span><span dir=\"auto\">\u5c55\u793a\u4e86MDS-UPDRS\u7684\u8be6\u7ec6\u57fa\u7ebf\u548c12\u4e2a\u6708\u6bd4\u8f83\u7ed3\u679c\u3002\u4f4e\u5242\u91cf\u7ec4\u548c\u9ad8\u5242\u91cf\u7ec4\u7684MDS-UPDRS I\u3001II\u3001IV\u90e8\u5206\u53ca\u603b\u5206\u5747\u663e\u8457\u63d0\u9ad8\u3002\u57fa\u4e8e\u5e15\u91d1\u68ee\u75c5\u65e5\u8bb0\u4e2d16\u5c0f\u65f6\u6e05\u9192\u65f6\u95f4\uff0c12\u4e2a\u6708\u65f6\uff0c\u4f4e\u5242\u91cf\u7ec4\u5e73\u5747\u6bcf\u65e5\u6e05\u9192\u65f6\u95f4\u4ece7.56\u5c0f\u65f6\u51cf\u5c11\u81f33.92\u5c0f\u65f6\uff08-3.64\u00b12.45\u5c0f\u65f6\uff0c<\/span><i><span dir=\"auto\">p<\/span><\/i><span dir=\"auto\">=0.031\uff09\uff0c\u9ad8\u5242\u91cf\u7ec4\u5e73\u5747\u6bcf\u65e5\u6e05\u9192\u65f6\u95f4\u4ece8.41\u5c0f\u65f6\u51cf\u5c11\u81f35.40\u5c0f\u65f6\uff08-3.01\u00b12.05\u5c0f\u65f6\uff0c<\/span><i><span dir=\"auto\">p=0.031\uff09\u3002<\/span><\/i><\/p>\n<section><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-19818 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/\u5fae\u4fe1\u56fe\u7247_2025-10-21_155710_099.png\" alt=\"\u56feS2\u57fa\u7ebf\u548c12\u4e2a\u6708\u65f6\u7684MDS-UPDRS\u90e8\u5206\u8bc4\u5206\uff0c\u4e0e\u56fe3\u76f8\u5173\" width=\"3321\" height=\"1475\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/\u5fae\u4fe1\u56fe\u7247_2025-10-21_155710_099.png 3321w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/\u5fae\u4fe1\u56fe\u7247_2025-10-21_155710_099-300x133.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/\u5fae\u4fe1\u56fe\u7247_2025-10-21_155710_099-1024x455.png 1024w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/\u5fae\u4fe1\u56fe\u7247_2025-10-21_155710_099-768x341.png 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/\u5fae\u4fe1\u56fe\u7247_2025-10-21_155710_099-1536x682.png 1536w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/\u5fae\u4fe1\u56fe\u7247_2025-10-21_155710_099-2048x910.png 2048w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/\u5fae\u4fe1\u56fe\u7247_2025-10-21_155710_099-18x8.png 18w\" sizes=\"(max-width: 3321px) 100vw, 3321px\" \/><\/section>\n<p><span dir=\"auto\">\u5176\u4ed6\u63a2\u7d22\u6027\u7597\u6548\u6307\u6807\uff0c\u5305\u62ec\u975e\u8fd0\u52a8\u75c7\u72b6\u91cf\u8868 (NMSS)\u3001\u5e15\u91d1\u68ee\u75c5\u95ee\u5377 (PDQ-39) \u4ee5\u53caSchwab\u548cEngland\u65e5\u5e38\u751f\u6d3b\u6d3b\u52a8\u91cf\u8868 (SE-ADL) \u8bc4\u5206\uff0c\u5728\u4e24\u7ec4\u4e2d\u4e5f\u4ece\u57fa\u7ebf\u523012\u4e2a\u6708\u6709\u6240\u6539\u5584\uff08\u56feS3A\u2013S3F\uff09\u3002<\/span><\/p>\n<section><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-19817 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/\u5fae\u4fe1\u56fe\u7247_2025-10-21_155852_588.png\" alt=\"\u56feS3\u79fb\u690dA9-DPC\u540eNMSS\u3001PDQ-39SI\u3001SE-ADL\u3001\u8ba4\u77e5\u529f\u80fd\u548cLEDD \u7684\u7eb5\u5411\u53d8\u5316\uff08\u4e0e\u56fe3\u76f8\u5173\uff09\" width=\"3321\" height=\"1910\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/\u5fae\u4fe1\u56fe\u7247_2025-10-21_155852_588.png 3321w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/\u5fae\u4fe1\u56fe\u7247_2025-10-21_155852_588-300x173.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/\u5fae\u4fe1\u56fe\u7247_2025-10-21_155852_588-1024x589.png 1024w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/\u5fae\u4fe1\u56fe\u7247_2025-10-21_155852_588-768x442.png 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/\u5fae\u4fe1\u56fe\u7247_2025-10-21_155852_588-1536x883.png 1536w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/\u5fae\u4fe1\u56fe\u7247_2025-10-21_155852_588-2048x1178.png 2048w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/\u5fae\u4fe1\u56fe\u7247_2025-10-21_155852_588-18x10.png 18w\" sizes=\"(max-width: 3321px) 100vw, 3321px\" \/><\/section>\n<p>\u7279\u522b\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u572812\u4e2a\u6708\u7684\u7814\u7a76\u671f\u95f4\uff0c\u5c3d\u7ba1\u5141\u8bb8\u8c03\u6574\u836f\u7269\uff0c\u4f46\u6240\u6709\u60a3\u8005\u7684<span class=\"\">\u5de6\u65cb\u591a\u5df4\u7b49\u6548\u65e5\u5242\u91cf<\/span>\u4fdd\u6301\u7a33\u5b9a\u3002\u8fd9\u8868\u660e\u5176\u8fd0\u52a8\u529f\u80fd\u7684\u6539\u5584\u662f\u6e90\u4e8e\u7ec6\u80de\u79fb\u690d\u672c\u8eab\u5e26\u6765\u7684\u751f\u7406\u6027\u4fee\u590d\uff0c\u800c\u975e\u901a\u8fc7\u589e\u52a0\u4f20\u7edf\u836f\u7269\u5242\u91cf\u5b9e\u73b0\u7684\u3002\u540c\u65f6\uff0c\u8ba4\u77e5\u529f\u80fd\u5728\u6574\u4e2a\u968f\u8bbf\u671f\u5185\u672a\u53d7\u5f71\u54cd\uff08\u8bf4\u660e\u8be5\u7597\u6cd5\u672a\u5f71\u54cd\u8ba4\u77e5\uff09\uff0c\u8fdb\u4e00\u6b65\u652f\u6301\u4e86\u8be5\u7597\u6cd5\u826f\u597d\u7684\u5b89\u5168\u6027\u7279\u5f81\u3002<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%E5%85%B3%E9%94%AE%E8%AF%81%E6%8D%AE%EF%BC%9A%E5%BD%B1%E5%83%8F%E5%AD%A6%E8%AF%81%E5%AE%9E%E7%BB%86%E8%83%9E%E5%AD%98%E6%B4%BB%E3%80%81%E6%95%B4%E5%90%88%E4%B8%8E%E5%8A%9F%E8%83%BD%E5%85%B3%E8%81%94\"><\/span><strong>\u5173\u952e\u8bc1\u636e\uff1a\u5f71\u50cf\u5b66\u8bc1\u5b9e\u7ec6\u80de\u5b58\u6d3b\u3001\u6574\u5408\u4e0e\u529f\u80fd\u5173\u8054<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><strong>\u5b89\u5168\u6027\u9a8c\u8bc1\uff1a<\/strong>\u6839\u636e\u672f\u540e\u5f71\u50cf\u5b66\u8bc4\u4f30\uff0c\u4eba\u80da\u80ce\u5e72\u7ec6\u80de\u884d\u751f\u7684A9-DPC\u7597\u6cd5\u5728\u5e15\u91d1\u68ee\u75c5\u60a3\u8005\u4e2d\u663e\u793a\u51fa\u79ef\u6781\u7ed3\u679c\u3002\u9996\u5148\uff0c\u5b89\u5168\u6027\u4e0e\u79fb\u690d\u51c6\u786e\u6027\u5f97\u5230\u786e\u8ba4\uff1a\u8111\u90e8MRI\u626b\u63cf\u663e\u793a\uff0c\u79fb\u690d\u90e8\u4f4d\u672a\u51fa\u73b0\u80bf\u7624\u6216\u708e\u75c7\u8ff9\u8c61<span dir=\"auto\" data-pm-slice=\"0 0 []\">\uff08<\/span><span dir=\"auto\">\u56feS4<\/span><span dir=\"auto\">A\u548cS4B<\/span><span dir=\"auto\">\uff09<\/span>\uff0c\u9488\u9053\u8f68\u8ff9\u8bc1\u5b9e\u7ec6\u80de\u88ab\u7cbe\u786e\u9012\u9001\u81f3\u76ee\u6807\u533a\u57df\u2014\u2014\u58f3\u6838\uff1b\u540c\u65f6\uff0c\u00b9\u2078F-FDG PET\u672a\u68c0\u6d4b\u5230\u7ec6\u80de\u7684\u5f02\u5e38\u589e\u6b96\u6216\u8fc1\u79fb\uff0c\u5171\u540c\u8bc1\u660e\u4e86\u8be5\u7597\u6cd5\u7684\u89e3\u5256\u7cbe\u51c6\u6027\u548c\u77ed\u671f\u5b89\u5168\u6027\u3002<\/p>\n<section>\n<div id=\"attachment_19827\" style=\"width: 760px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-19827\" class=\"wp-image-19827 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/figs4.jpg\" alt=\"\u56feS4\uff1aA9-DPC\u79fb\u690d\u540e\u8111MRI\u7684\u4ee3\u8868\u6027\u56fe\u50cf\u548c18F-FP-CIT\u6444\u53d6\u7684\u4e2a\u4f53\u6c34\u5e73\u53d8\u5316\uff0c\u4e0e\u56fe4\u76f8\u5173\" width=\"750\" height=\"411\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/figs4.jpg 750w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/figs4-300x164.jpg 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/figs4-18x10.jpg 18w\" sizes=\"(max-width: 750px) 100vw, 750px\" \/><p id=\"caption-attachment-19827\" class=\"wp-caption-text\">\u00a0<\/p><\/div>\n<\/section>\n<p><strong>\u7ec6\u80de\u5b58\u6d3b\u4e0e\u529f\u80fd\u6574\u5408\uff1a<\/strong>\u5728\u7ec6\u80de\u5b58\u6d3b\u4e0e\u529f\u80fd\u6574\u5408\u65b9\u9762\uff0c\u8fde\u7eed\u7684\u591a\u5df4\u80fa\u8f6c\u8fd0\u4f53\uff08<span class=\"\">DAT<\/span>\uff09\u5f71\u50cf\uff08\u00b9\u2078F-FP-CIT PET\uff09\u63d0\u4f9b\u4e86\u5173\u952e\u8bc1\u636e\u3002\u6570\u636e\u663e\u793a\uff0c\u79fb\u690d\u540e12\u4e2a\u6708\uff0c\u4f5c\u4e3a\u4e3b\u8981\u529f\u80fd\u6307\u6807\u7684\u540e\u80cc\u58f3\u6838\u533a\u7684DAT\u7279\u5f02\u6027\u7ed3\u5408\u7387\uff08SBR\uff09\u5448\u73b0\u5242\u91cf\u4f9d\u8d56\u6027\u589e\u52a0\uff0c\u9ad8\u5242\u91cf\u7ec4\u7684\u53d8\u5316\u5c24\u4e3a\u663e\u8457\uff1a\u9ad8\u5242\u91cf\u7ec4\u4e2d\u4f4d\u589e\u957f10.7%\uff08p=0.041\uff09\uff0c\u4f4e\u5242\u91cf\u7ec4\u589e\u957f1.0%\u3002<\/p>\n<p>\u8fd9\u4e00\u7ed3\u679c\u8868\u660e\uff0c\u79fb\u690d\u7684\u7ec6\u80de\u4e0d\u4ec5\u5b58\u6d3b\uff0c\u800c\u4e14\u6210\u529f\u5728\u5173\u952e\u8111\u533a\u5efa\u7acb\u4e86\u65b0\u7684\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u652f\u914d\u3002<\/p>\n<section>\n<div id=\"attachment_19826\" style=\"width: 760px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-19826\" class=\"wp-image-19826 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/gr4-3.jpg\" alt=\"\u56fe4\uff1a\u57fa\u7ebf\u548cA9-DPC\u79fb\u690d\u540e12\u4e2a\u6708\u768418F-FP-CITSBR\" width=\"750\" height=\"309\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/gr4-3.jpg 750w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/gr4-3-300x124.jpg 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/gr4-3-18x7.jpg 18w\" sizes=\"(max-width: 750px) 100vw, 750px\" \/><p id=\"caption-attachment-19826\" class=\"wp-caption-text\">\uff08A\uff09\u7eb9\u72b6\u4f53\u4e2d\u768418 F-FP-CIT SBR \u56fe\u50cf\u3002\u56fe\u4e2d\u663e\u793a\u4e86\u6240\u6709\u53c2\u4e0e\u8005\uff08n = 12\uff09\u5728\u57fa\u7ebf\u548c A9-DPC \u79fb\u690d\u540e 12 \u4e2a\u6708\u7684\u5e73\u574718 F-FP-CIT SBR \u7684\u8f74\u5411\u56fe\u50cf\u3002SBR \u56fe\u50cf\u4ee5\u5c0f\u8111\u7070\u8d28\u4e3a\u53c2\u8003\u7ec4\u7ec7\u751f\u6210\u3002SBR \u7684\u8ba1\u7b97\u65b9\u6cd5\u662f\u5c06\u6bcf\u4e2a\u4f53\u7d20\u4e0e\u53c2\u8003\u533a\u57df\u7684\u6444\u53d6\u503c\u4e4b\u5dee\u9664\u4ee5\u53c2\u8003\u533a\u57df\u7684\u6444\u53d6\u503c\u3002 (B)\u57fa\u7ebf\u548c A9-DPC \u79fb\u690d\u540e 12 \u4e2a\u6708\u7684\u7ec4\u5e73\u574718 F-FP-CIT SBR \u56fe\u50cf\u3002\u56fe\u4e2d\u663e\u793a\u4e86\u4f4e\u5242\u91cf\u7ec4\u548c\u9ad8\u5242\u91cf\u7ec4\u57fa\u7ebf\u548c\u79fb\u690d\u540e 12 \u4e2a\u6708\u7684\u5e73\u574718 F-FP-CIT SBR \u7684\u8f74\u5411\u56fe\u50cf\u3002SBR \u56fe\u50cf\u4ee5\u5c0f\u8111\u7070\u8d28\u4e3a\u53c2\u8003\u7ec4\u7ec7\u751f\u6210\u3002SBR \u7684\u8ba1\u7b97\u65b9\u6cd5\u662f\u5c06\u6bcf\u4e2a\u4f53\u7d20\u4e0e\u53c2\u8003\u533a\u57df\u7684\u6444\u53d6\u503c\u4e4b\u5dee\u9664\u4ee5\u53c2\u8003\u533a\u57df\u7684\u6444\u53d6\u503c\u3002 \uff08C\uff09 18 F-FP-CIT SBR\u7684\u533a\u57df\u53d8\u5316\u3002\u56fe\u4e2d\u663e\u793a\u4e86\u6bcf\u4e2a\u4e9a\u533a\u57df\u4f4e\u5242\u91cf\u7ec4\u548c\u9ad8\u5242\u91cf\u7ec4\u4ece\u57fa\u7ebf\u5230 12 \u4e2a\u6708\u7684 SBR \u767e\u5206\u6bd4\u53d8\u5316\u3002\u7bb1\u7ebf\u56fe\u663e\u793a\u4e2d\u4f4d\u6570\uff08\u6c34\u5e73\u7ebf\uff09\u3001IQR\uff08\u7bb1\u7ebf\u56fe\uff09\u548c\u5168\u8303\u56f4\uff08\u987b\u7ebf\u56fe\uff09\uff0c\u5e76\u53e0\u52a0\u4e86\u4e2a\u4f53\u60a3\u8005\u503c\u3002\u4f7f\u7528 Wilcoxon \u79e9\u548c\u68c0\u9a8c\u8ba1\u7b97\u7ec4\u95f4\u6bd4\u8f83\u7684p\u503c\u3002<\/p><\/div>\n<\/section>\n<p><strong>\u673a\u5236\u5173\u8054\uff1a<\/strong>\u7edf\u8ba1\u5206\u6790\u8bc1\u5b9e\uff0c\u540e\u80cc\u58f3\u6838\u533aDAT\u6d3b\u6027\u7684\u63d0\u5347\u4e0e\u60a3\u8005\u6838\u5fc3\u8fd0\u52a8\u529f\u80fd\u7684\u6539\u5584\u7a0b\u5ea6\u5448\u663e\u8457\u6b63\u76f8\u5173\uff0c\u4e3a\u201c\u79fb\u690d\u7ec6\u80de\u901a\u8fc7\u6062\u590d\u591a\u5df4\u80fa\u795e\u7ecf\u652f\u914d\u6765\u7f13\u89e3\u75c7\u72b6\u201d\u63d0\u4f9b\u4e86\u6700\u76f4\u63a5\u7684\u8bc1\u636e\u3002<\/p>\n<section>\n<div id=\"attachment_19823\" style=\"width: 2916px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-19823\" class=\"wp-image-19823 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/\u5fae\u4fe1\u56fe\u7247_2025-10-21_144201_986.png\" alt=\"\u56feS5\uff1a\u540e\u80cc\u58f3\u6838\u4e2d18F-FP-CIT PETSBR\u7684\u53d8\u5316\u4e0e\u8fd0\u52a8\u6539\u5584\u4e4b\u95f4\u7684\u76f8\u5173\u6027\uff0c\u4e0e\u56fe4\u76f8\u5173\" width=\"2906\" height=\"1566\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/\u5fae\u4fe1\u56fe\u7247_2025-10-21_144201_986.png 2906w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/\u5fae\u4fe1\u56fe\u7247_2025-10-21_144201_986-300x162.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/\u5fae\u4fe1\u56fe\u7247_2025-10-21_144201_986-1024x552.png 1024w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/\u5fae\u4fe1\u56fe\u7247_2025-10-21_144201_986-768x414.png 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/\u5fae\u4fe1\u56fe\u7247_2025-10-21_144201_986-1536x828.png 1536w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/\u5fae\u4fe1\u56fe\u7247_2025-10-21_144201_986-2048x1104.png 2048w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/\u5fae\u4fe1\u56fe\u7247_2025-10-21_144201_986-18x10.png 18w\" sizes=\"(max-width: 2906px) 100vw, 2906px\" \/><p id=\"caption-attachment-19823\" class=\"wp-caption-text\">(A) \u6563\u70b9\u56fe\u663e\u793a\u4e86\u53d8\u5316\u8f83\u6709\u5229\u4fa7\uff08\u4ece\u57fa\u7ebf\u5f00\u59cb\uff09\u540e\u80cc\u58f3\u6838\u4e2d18 F-FP-CIT PET SBR \u767e\u5206\u6bd4\u7684\u53d8\u5316\u4e0e MDS-UPDRS \u7b2c\u4e09\u90e8\u5206 (OFF) \u8bc4\u5206\uff08\u4e0d\u5305\u62ec\u9707\u98a4\u5b50\u8bc4\u5206\uff09\u767e\u5206\u6bd4\u53d8\u5316\u4e4b\u95f4\u7684\u76f8\u5173\u6027\uff08 n = 12\uff09\u3002\u4f7f\u7528 Spearman \u7b49\u7ea7\u76f8\u5173\u7cfb\u6570\u8ba1\u7b97p\u503c\u3002 (B) \u6563\u70b9\u56fe\u663e\u793a\u53d8\u5316\u8f83\u6709\u5229\u4fa7\uff08\u4e0e\u57fa\u7ebf\u76f8\u6bd4\uff09\u540e\u80cc\u58f3\u6838\u4e2d18 F-FP-CIT PET SBR \u767e\u5206\u6bd4\u53d8\u5316\u4e0e\u4f4e\u5242\u91cf\u7ec4 ( n = 6) \u4e2d MDS-UPDRS \u7b2c\u4e09\u90e8\u5206 (OFF) \u8bc4\u5206\uff08\u4e0d\u5305\u62ec\u9707\u98a4\u5206\u9879\uff09\u767e\u5206\u6bd4\u53d8\u5316\u4e4b\u95f4\u7684\u76f8\u5173\u6027\u3002\u6839\u636e\u4e24\u9879\u6307\u6807\u662f\u5426\u5747\u663e\u793a\u51fa\u4e00\u81f4\u4e14\u663e\u8457\u7684\u6539\u5584\uff0c\u5c06\u4f4e\u5242\u91cf\u7ec4\u60a3\u8005\u5206\u4e3a\u53cd\u5e94\u4e0d\u826f\u6216\u53cd\u5e94\u826f\u597d\u8005\u3002\u9274\u4e8e\u9ad8\u5242\u91cf\u7ec4\u6240\u6709\u60a3\u8005\u7684\u4e24\u9879\u6307\u6807\u5747\u663e\u793a\u51fa\u4e00\u81f4\u4e14\u663e\u8457\u7684\u6539\u5584\uff0c\u6211\u4eec\u5c06\u4f4e\u5242\u91cf\u7ec4 ( n = 6) \u60a3\u8005\u5206\u4e3a\u4e09\u7ec4\u53cd\u5e94\u4e0d\u826f\u8005\uff08\u60a3\u8005 1\u30017 \u548c 10\uff1b\u6807\u8bb0\u4e3a\u7ea2\u8272\uff09\u548c\u4e09\u7ec4\u53cd\u5e94\u826f\u597d\u8005\uff08\u60a3\u8005 2\u30013 \u548c 9\uff1b\u6807\u8bb0\u4e3a\u84dd\u8272\uff09\u3002 (C) \u4f7f\u7528\u4e2d\u4f4d\u6570 (Q1, Q3) \u548c\u5e73\u5747\u503c (SD) \u6c47\u603b\u5404\u7ec4\u57fa\u7ebf\u7279\u5f81\u3002\u5404\u7ec4\u57fa\u7ebf\u5e74\u9f84\u76f8\u5f53\uff0c\u4f46\u7597\u6548\u826f\u597d\u60a3\u8005\u7684\u57fa\u7ebf\u8fd0\u52a8\u7f3a\u9677\u7a0b\u5ea6\u4f3c\u4e4e\u8f83\u8f7b\uff0c\u8fd9\u4f53\u73b0\u5728\u8f83\u4f4e\u7684 MDS-UPDRS \u7b2c\u4e09\u90e8\u5206 (OFF) \u8bc4\u5206\u4e0a\u3002<\/p><\/div>\n<\/section>\n<h2><span class=\"ez-toc-section\" id=\"%E7%A0%94%E7%A9%B6%E6%84%8F%E4%B9%89%E4%B8%8E%E5%B1%95%E6%9C%9B%EF%BC%9A%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E5%B8%95%E9%87%91%E6%A3%AE%E7%97%85%E7%9A%84%E9%87%8C%E7%A8%8B%E7%A2%91\"><\/span><strong>\u7814\u7a76\u610f\u4e49\u4e0e\u5c55\u671b\uff1a\u5e72\u7ec6\u80de\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\u7684\u91cc\u7a0b\u7891<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>\u8fd9\u9879\u5355\u4e2d\u5fc3\u3001\u5f00\u653e\u6807\u7b7e\u3001\u5242\u91cf\u9012\u589e\u76841\/2a\u671f\u8bd5\u9a8c\u8868\u660e\uff0c\u5bf9\u4e8e\u75c5\u53f2\u8d85\u8fc75\u5e74\u7684\u4e2d\u91cd\u5ea6\u5e15\u91d1\u68ee\u75c5\u60a3\u8005\uff0c\u53cc\u4fa7\u58f3\u6838\u79fb\u690d\u4eba\u80da\u80ce\u5e72\u7ec6\u80de\u884d\u751f\u7684A9-DPC\u603b\u4f53\u5b89\u5168\u4e14\u53ef\u8010\u53d7\u3002<\/p>\n<p>\u7814\u7a76\u671f\u95f4\u672a\u89c2\u5bdf\u5230\u80bf\u7624\u5f62\u6210\u3001\u79fb\u690d\u7269\u8fc7\u5ea6\u751f\u957f\u3001\u5f02\u4f4d\u7ec6\u80de\u8fc1\u79fb\u6216\u514d\u75ab\u4ecb\u5bfc\u7684\u708e\u75c7\u53cd\u5e94\u3002\u624b\u672f\u64cd\u4f5c\u7cbe\u51c6\uff0c72\u6761\u7acb\u4f53\u5b9a\u5411\u8f68\u8ff9\u4e2d\u4ec5\u51fa\u73b01\u4f8b\u65e0\u75c7\u72b6\u6027\u8111\u51fa\u8840\uff081.39%\uff09\uff0c\u4e0e\u8be5\u7c7b\u624b\u672f\u9884\u671f\u98ce\u9669\u4e00\u81f4\u3002<\/p>\n<p>\u6b64\u9879\u7814\u7a76\u4f5c\u4e3a<strong>\u9996\u4e2a\u8fdb\u5165\u4e34\u5e8a\u9636\u6bb5\u7684\u4eba\u80da\u80ce\u5e72\u7ec6\u80de\u884d\u751f\u7684\u9ad8\u7eaf\u5ea6\u591a\u5df4\u80fa\u80fd\u7956\u7ec6\u80de\uff08A9-DPC\uff09\u7597\u6cd5<\/strong>\uff0c\u7cfb\u7edf\u6027\u5730\u56de\u7b54\u4e86\u7ec6\u80de\u6cbb\u7597\u9886\u57df\u7684\u4e09\u5927\u6838\u5fc3\u95ee\u9898\uff1a<\/p>\n<section data-role=\"list\">\n<ul class=\"list-paddingleft-1\">\n<li>\u5b89\u5168\u6027\u65b9\u9762\uff1a\u7814\u7a76\u8bc1\u5b9e\u65e0\u4e25\u91cd\u7ec6\u80de\u76f8\u5173\u4e0d\u826f\u53cd\u5e94\uff1b<\/li>\n<li>\u6709\u6548\u6027\u65b9\u9762\uff1a91.7%\u7684\u60a3\u8005\u5728\u505c\u836f\u72b6\u6001\u4e0b\u8fd0\u52a8\u529f\u80fd\u6539\u5584\uff0c\u4e14\u9ad8\u5242\u91cf\u7ec4\u8868\u73b0\u51fa\u66f4\u663e\u8457\u7684\u4e34\u5e8a\u83b7\u76ca\uff0c\u5e76\u6709\u5f71\u50cf\u5b66\u8bc1\u636e\u652f\u6301\u5176\u4f5c\u7528\u673a\u5236\uff1b<\/li>\n<li>\u53ef\u884c\u6027\u65b9\u9762\uff1a\u901a\u8fc7GMP\u6761\u4ef6\u4e0b\u7684\u6807\u51c6\u5316\u751f\u4ea7\u4f53\u7cfb\uff0c\u6210\u529f\u5b9e\u73b0\u4e86\u4e34\u5e8a\u7ea7\u7ec6\u80de\u4ea7\u54c1\u7684\u7a33\u5b9a\u4f9b\u5e94\u3002<\/li>\n<\/ul>\n<\/section>\n<p>\u7597\u6548\u6570\u636e\u663e\u793a\uff0cA9-DPC\u79fb\u690d\u4e3a\u60a3\u8005\u5e26\u6765\u4e86\u5177\u6709\u4e34\u5e8a\u610f\u4e49\u7684\u6539\u5584\u3002\u9664\u8fd0\u52a8\u529f\u80fd\u8bc4\u5206\uff08MDS-UPDRS III\uff09\u548c\u75be\u75c5\u5206\u671f\uff08H&amp;Y\uff09\u7684\u663e\u8457\u6539\u5584\u5916\uff0c\u60a3\u8005\u6bcf\u65e5&#8221;\u5173\u671f&#8221;\u65f6\u95f4\u51cf\u5c11\uff0c\u751f\u6d3b\u8d28\u91cf\u3001\u975e\u8fd0\u52a8\u75c7\u72b6\u53ca\u65e5\u5e38\u751f\u6d3b\u80fd\u529b\u8bc4\u5206\u4e5f\u5747\u83b7\u63d0\u9ad8\u3002\u8fd9\u4e9b\u53d1\u73b0\u4e3a\u7ec6\u80de\u7597\u6cd5\u7684\u6cbb\u7597\u4ef7\u503c\u63d0\u4f9b\u4e86\u6709\u529b\u652f\u6301\u3002<\/p>\n<p>\u57fa\u4e8e\u8fd9\u4e9b\u79ef\u6781\u6210\u679c\uff0c\u7814\u7a76\u56e2\u961f\u4e0b\u4e00\u6b65\u5c06\u5f00\u5c55\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u7684\u591a\u4e2d\u5fc3\u8bd5\u9a8c\uff0c\u7eb3\u5165\u66f4\u591a\u60a3\u8005\u5e76\u5ef6\u957f\u968f\u8bbf\u65f6\u95f4\u3002\u82e5\u7ed3\u679c\u5f97\u4ee5\u9a8c\u8bc1\uff0c\u8be5\u7597\u6cd5\u6709\u671b\u4e3a\u5e15\u91d1\u68ee\u75c5\u60a3\u8005\u5e26\u6765\u957f\u671f\u75c7\u72b6\u7f13\u89e3\u7684\u65b0\u5e0c\u671b\u3002<\/p>\n<\/section>\n<section>\n<section>\n<blockquote><p>References:<\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">[1]\uff1ahttps:\/\/www.acnnewswire.com\/press-release\/japanese\/101164\/s.biomedics-cell-therapy-for-parkinson&#8217;s-disease-shows-positive-data-from-its-phase-1\/2a-clinical-trial<\/span><\/span><\/p>\n<p>Disclaimer: This article is intended only to disseminate scientific knowledge and share industry perspectives, and does not constitute any clinical diagnostic advice! The information published by Hangi Stem Cells is not a substitute for the professional advice of a physician or pharmacist. 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