{"id":19877,"date":"2025-10-22T16:26:33","date_gmt":"2025-10-22T08:26:33","guid":{"rendered":"https:\/\/www.hjtdsm.cn\/?p=19877"},"modified":"2025-10-22T16:26:51","modified_gmt":"2025-10-22T08:26:51","slug":"https-www-hjtdsm-cn-stem-cells-psc-19877-html","status":"publish","type":"post","link":"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/psc\/19877.html","title":{"rendered":"\u591a\u80fd\u5e72\u7ec6\u80de\u6cbb\u7597\u6548\u679c\u5982\u4f55\uff1f2025\u6700\u65b0\u4e34\u5e8a\u7814\u7a76\u4e0e\u771f\u5b9e\u6848\u4f8b\u6c47\u603b"},"content":{"rendered":"<p>\u5728\u518d\u751f\u533b\u5b66\u7684\u4f17\u591a\u7814\u7a76\u65b9\u5411\u4e2d\uff0c<a href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/psc\/19802.html\/\" target=\"_blank\" rel=\"noopener\">pluripotent stem cell<\/a>\uff08Pluripotent Stem Cells\uff0c\u7b80\u79f0PSCs\uff09\u65e0\u7591\u662f\u6700\u5f15\u4eba\u6ce8\u76ee\u7684\u4e00\u4e2a\u3002\u51ed\u501f\u201c\u5206\u5316\u4e3a\u4eba\u4f53\u4efb\u610f\u7ec6\u80de\u7c7b\u578b\u201d\u7684\u72ec\u7279\u80fd\u529b\uff0c\u5b83\u88ab\u89c6\u4e3a\u653b\u514b\u591a\u79cd\u7591\u96be\u75be\u75c5\u7684\u5173\u952e\u7a81\u7834\u53e3\u3002<\/p>\n<p>\u90a3\u4e48\uff0c<strong>\u591a\u80fd\u5e72\u7ec6\u80de\u6cbb\u7597\u7684\u5b9e\u9645\u6548\u679c\u7a76\u7adf\u5982\u4f55\uff1f\u5b83\u76ee\u524d\u5904\u5728\u4ec0\u4e48\u9636\u6bb5\uff1f\u672c\u6587\u5c06\u4ece\u539f\u7406\u3001\u7814\u7a76\u8fdb\u5c55\u4e0e\u4e34\u5e8a\u5e94\u7528\u7b49\u591a\u4e2a\u65b9\u9762\uff0c\u4e3a\u4f60\u6df1\u5165\u89e3\u6790<\/strong>The<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-19879 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/0f402680-7d1a-4e08-96dd-acabe3fa658f.png\" alt=\"\u591a\u80fd\u5e72\u7ec6\u80de\u6cbb\u7597\u6548\u679c\u5982\u4f55\uff1f\u6700\u65b0\u4e34\u5e8a\u7814\u7a76\u4e0e\u771f\u5b9e\u6848\u4f8b\u6c47\u603b\" width=\"612\" height=\"408\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/0f402680-7d1a-4e08-96dd-acabe3fa658f.png 612w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/0f402680-7d1a-4e08-96dd-acabe3fa658f-300x200.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/0f402680-7d1a-4e08-96dd-acabe3fa658f-18x12.png 18w\" sizes=\"(max-width: 612px) 100vw, 612px\" \/><\/p>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_79_2 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewbox=\"0 0 24 24\" version=\"1.2\" baseprofile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1' ><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/psc\/19877.html\/#%E5%A4%9A%E8%83%BD%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E6%95%88%E6%9E%9C%E5%A6%82%E4%BD%95%EF%BC%9F2025%E6%9C%80%E6%96%B0%E4%B8%B4%E5%BA%8A%E7%A0%94%E7%A9%B6%E4%B8%8E%E7%9C%9F%E5%AE%9E%E6%A1%88%E4%BE%8B%E6%B1%87%E6%80%BB\" >\u591a\u80fd\u5e72\u7ec6\u80de\u6cbb\u7597\u6548\u679c\u5982\u4f55\uff1f2025\u6700\u65b0\u4e34\u5e8a\u7814\u7a76\u4e0e\u771f\u5b9e\u6848\u4f8b\u6c47\u603b<\/a><ul class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/psc\/19877.html\/#%E4%B8%80%E3%80%81%E5%A4%9A%E8%83%BD%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E7%9A%84%E5%8E%9F%E7%90%86%EF%BC%9A%E8%AE%A9%E5%8F%97%E6%8D%9F%E7%BB%84%E7%BB%87%E2%80%9C%E5%86%8D%E7%94%9F%E2%80%9D\" >\u4e00\u3001\u591a\u80fd\u5e72\u7ec6\u80de\u6cbb\u7597\u7684\u539f\u7406\uff1a\u8ba9\u53d7\u635f\u7ec4\u7ec7\u201c\u518d\u751f\u201d<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/psc\/19877.html\/#%E4%BA%8C%E3%80%81%E5%A4%9A%E8%83%BD%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E6%95%88%E6%9E%9C%E5%A6%82%E4%BD%95%EF%BC%9F%E6%9C%80%E6%96%B0%E4%B8%B4%E5%BA%8A%E7%A0%94%E7%A9%B6%E6%88%90%E6%9E%9C%EF%BC%9A%E4%BB%8E%E2%80%9C%E6%94%B9%E5%96%84%E2%80%9D%E5%88%B0%E2%80%9C%E5%8A%9F%E8%83%BD%E6%80%A7%E6%B2%BB%E6%84%88%E2%80%9D\" >\u4e8c\u3001\u591a\u80fd\u5e72\u7ec6\u80de\u6cbb\u7597\u6548\u679c\u5982\u4f55\uff1f\u6700\u65b0\u4e34\u5e8a\u7814\u7a76\u6210\u679c\uff1a\u4ece\u201c\u6539\u5584\u201d\u5230\u201c\u529f\u80fd\u6027\u6cbb\u6108\u201d<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/psc\/19877.html\/#1%E5%B8%95%E9%87%91%E6%A3%AE%E7%97%85\" >1.\u5e15\u91d1\u68ee\u75c5<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/psc\/19877.html\/#2%E7%B3%96%E5%B0%BF%E7%97%85\" >2.\u7cd6\u5c3f\u75c5<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/psc\/19877.html\/#3%E8%A7%86%E7%BD%91%E8%86%9C%E9%80%80%E5%8C%96%E6%80%A7%E7%96%BE%E7%97%85\" >3.\u89c6\u7f51\u819c\u9000\u5316\u6027\u75be\u75c5<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/psc\/19877.html\/#4%E8%84%8A%E9%AB%93%E6%8D%9F%E4%BC%A4\" >4.\u810a\u9ad3\u635f\u4f24<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/psc\/19877.html\/#%E4%B8%89%E3%80%81%E7%96%97%E6%95%88%E5%BD%B1%E5%93%8D%E5%9B%A0%E7%B4%A0%EF%BC%9A%E4%B8%8D%E6%98%AF%E6%89%80%E6%9C%89%E6%82%A3%E8%80%85%E6%95%88%E6%9E%9C%E9%83%BD%E4%B8%80%E6%A0%B7\" >\u4e09\u3001\u7597\u6548\u5f71\u54cd\u56e0\u7d20\uff1a\u4e0d\u662f\u6240\u6709\u60a3\u8005\u6548\u679c\u90fd\u4e00\u6837<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/psc\/19877.html\/#%E5%9B%9B%E3%80%81%E6%9C%AA%E6%9D%A5%E5%B1%95%E6%9C%9B%E4%B8%8E%E6%8C%91%E6%88%98\" >\u56db\u3001\u672a\u6765\u5c55\u671b\u4e0e\u6311\u6218<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/psc\/19877.html\/#%E7%BB%93%E8%AF%AD\" >concluding remarks<\/a><\/li><\/ul><\/li><\/ul><\/nav><\/div>\n<h1><span class=\"ez-toc-section\" id=\"%E5%A4%9A%E8%83%BD%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E6%95%88%E6%9E%9C%E5%A6%82%E4%BD%95%EF%BC%9F2025%E6%9C%80%E6%96%B0%E4%B8%B4%E5%BA%8A%E7%A0%94%E7%A9%B6%E4%B8%8E%E7%9C%9F%E5%AE%9E%E6%A1%88%E4%BE%8B%E6%B1%87%E6%80%BB\"><\/span>\u591a\u80fd\u5e72\u7ec6\u80de\u6cbb\u7597\u6548\u679c\u5982\u4f55\uff1f2025\u6700\u65b0\u4e34\u5e8a\u7814\u7a76\u4e0e\u771f\u5b9e\u6848\u4f8b\u6c47\u603b<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<h2><span class=\"ez-toc-section\" id=\"%E4%B8%80%E3%80%81%E5%A4%9A%E8%83%BD%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E7%9A%84%E5%8E%9F%E7%90%86%EF%BC%9A%E8%AE%A9%E5%8F%97%E6%8D%9F%E7%BB%84%E7%BB%87%E2%80%9C%E5%86%8D%E7%94%9F%E2%80%9D\"><\/span><strong>\u4e00\u3001\u591a\u80fd\u5e72\u7ec6\u80de\u6cbb\u7597\u7684\u539f\u7406\uff1a\u8ba9\u53d7\u635f\u7ec4\u7ec7\u201c\u518d\u751f\u201d<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p data-start=\"303\" data-end=\"393\">\u591a\u80fd\u5e72\u7ec6\u80de\u5305\u62ec\u4e24\u79cd\u7c7b\u578b\uff1a<strong>embryonic stem cell<\/strong>\uff08ESCs\uff09\u548c<strong>induced pluripotent stem cell<\/strong>\uff08iPSCs\uff09\u3002\u5b83\u4eec\u90fd\u5177\u5907\u5f3a\u5927\u7684\u201c\u591a\u5411\u5206\u5316\u80fd\u529b\u201d\u2014\u2014\u53ef\u8f6c\u53d8\u4e3a\u795e\u7ecf\u7ec6\u80de\u3001\u5fc3\u808c\u7ec6\u80de\u3001\u80f0\u5c9b\u03b2\u7ec6\u80de\u7b49\u4e0d\u540c\u7c7b\u578b\u7684\u529f\u80fd\u7ec6\u80de\u3002<\/p>\n<p data-start=\"395\" data-end=\"446\">\u5728\u6cbb\u7597\u4e2d\uff0c\u79d1\u7814\u4eba\u5458\u901a\u5e38\u5c06PSCs\u5b9a\u5411\u8bf1\u5bfc\u4e3a\u7279\u5b9a\u7ec6\u80de\uff0c\u518d\u79fb\u690d\u5230\u60a3\u8005\u4f53\u5185\uff0c\u7528\u4e8e\u66ff\u4ee3\u6216\u4fee\u590d\u53d7\u635f\u7684\u7ec4\u7ec7\u3002\u4f8b\u5982\uff1a<\/p>\n<ul data-start=\"448\" data-end=\"560\">\n<li data-start=\"448\" data-end=\"488\">\n<p data-start=\"450\" data-end=\"488\"><strong data-start=\"450\" data-end=\"458\">Parkinson's disease<\/strong>\uff1a\u5c06\u591a\u80fd\u5e72\u7ec6\u80de\u5206\u5316\u4e3a\u591a\u5df4\u80fa\u795e\u7ecf\u5143\uff0c\u8865\u5145\u75c5\u53d8\u533a\u57df\u7f3a\u5931\u7684\u795e\u7ecf\u5143\uff1b<\/p>\n<\/li>\n<li data-start=\"489\" data-end=\"519\">\n<p data-start=\"491\" data-end=\"519\"><strong data-start=\"491\" data-end=\"498\">diabetes<\/strong>\uff1a\u8bf1\u5bfc\u5f62\u6210\u80f0\u5c9b\u03b2\u7ec6\u80de\uff0c\u5e2e\u52a9\u6062\u590d\u80f0\u5c9b\u7d20\u5206\u6ccc\uff1b<\/p>\n<\/li>\n<li data-start=\"520\" data-end=\"560\">\n<p data-start=\"522\" data-end=\"560\"><strong data-start=\"522\" data-end=\"534\">\u5fc3\u810f\u75c5\u4e0e\u810a\u9ad3\u635f\u4f24<\/strong>\uff1a\u751f\u6210\u5fc3\u808c\u7ec6\u80de\u6216\u795e\u7ecf\u5143\u7ec6\u80de\uff0c\u4fee\u590d\u574f\u6b7b\u7ec4\u7ec7\u3001\u91cd\u5efa\u529f\u80fd\u3002<\/p>\n<\/li>\n<\/ul>\n<p data-start=\"562\" data-end=\"598\">\u8fd9\u4e00\u673a\u5236\u8ba9\u201c\u5668\u5b98\u81ea\u6211\u4fee\u590d\u201d\u4e0d\u518d\u53ea\u662f\u8bbe\u60f3\uff0c\u800c\u6210\u4e3a\u8d8a\u6765\u8d8a\u63a5\u8fd1\u73b0\u5b9e\u7684\u533b\u5b66\u65b9\u6848\u3002<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%E4%BA%8C%E3%80%81%E5%A4%9A%E8%83%BD%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E6%95%88%E6%9E%9C%E5%A6%82%E4%BD%95%EF%BC%9F%E6%9C%80%E6%96%B0%E4%B8%B4%E5%BA%8A%E7%A0%94%E7%A9%B6%E6%88%90%E6%9E%9C%EF%BC%9A%E4%BB%8E%E2%80%9C%E6%94%B9%E5%96%84%E2%80%9D%E5%88%B0%E2%80%9C%E5%8A%9F%E8%83%BD%E6%80%A7%E6%B2%BB%E6%84%88%E2%80%9D\"><\/span><strong>\u4e8c\u3001<\/strong><strong>\u591a\u80fd\u5e72\u7ec6\u80de\u6cbb\u7597\u6548\u679c\u5982\u4f55\uff1f<\/strong><strong>\u6700\u65b0\u4e34\u5e8a\u7814\u7a76\u6210\u679c\uff1a\u4ece\u201c\u6539\u5584\u201d\u5230\u201c\u529f\u80fd\u6027\u6cbb\u6108\u201d<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<h3><span class=\"ez-toc-section\" id=\"1%E5%B8%95%E9%87%91%E6%A3%AE%E7%97%85\"><\/span><strong>1.\u5e15\u91d1\u68ee\u75c5<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>2025\u5e7410\u670814\u65e5\uff0c<a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(25)01041-4?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867425010414%3Fshowall%3Dtrue\" target=\"_blank\" rel=\"nofollow noopener\">\u5ef6\u4e16\u5927\u5b66Severance\u7814\u7a76\u56e2\u961f<\/a>\u516c\u5e03\u4e86<strong>\u4e9a\u6d32\u5730\u533a\u9996\u6b21\u3001\u5168\u7403\u8303\u56f4\u5185\u7b2c\u4e8c\u6b21<\/strong>\u62a5\u9053\u7684\u901a\u8fc7<strong>\u79fb\u690d\u6e90\u81ea\u4eba\u80da\u80ce\u5e72\u7ec6\u80de\u7684A9\u578b\u591a\u5df4\u80fa\u524d\u4f53\u7ec6\u80de<\/strong>\uff08A9-DPC\uff09\uff0c\u6210\u529f\u5b9e\u73b0\u4e86\u5bf9\u4e2d\u91cd\u5ea6\u5e15\u91d1\u68ee\u75c5\u60a3\u8005\u7684\u7cbe\u51c6\u6cbb\u7597\u3002<sup>[1]<\/sup><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-19775\" title=\"\u5e72\u7ec6\u80de\u79fb\u690d\u6548\u679c\u600e\u4e48\u6837\uff1f2025\u6700\u65b0\u4e34\u5e8a\u6570\u636e\u4e0e\u771f\u5b9e\u60a3\u8005\u53cd\u9988 2\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/24c57b6c-0cd9-4799-9b69-d7f8bfcaf30e.png\" sizes=\"(max-width: 772px) 100vw, 772px\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/24c57b6c-0cd9-4799-9b69-d7f8bfcaf30e.png 960w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/24c57b6c-0cd9-4799-9b69-d7f8bfcaf30e-300x142.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/24c57b6c-0cd9-4799-9b69-d7f8bfcaf30e-768x364.png 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/24c57b6c-0cd9-4799-9b69-d7f8bfcaf30e-18x9.png 18w\" alt=\"hESC\u884d\u751f\u591a\u5df4\u80fa\u524d\u4f53\u7ec6\u80de\u5728\u5e15\u91d1\u68ee\u75c5\u4e2d\u7684I\/\u671f\u4e34\u5e8a\u8bd5\u9a8c\" width=\"772\" height=\"366\" \/><\/p>\n<p>\u8fd9\u9879\u5355\u4e2d\u5fc3\u3001\u5f00\u653e\u6807\u7b7e\u7684\u4e34\u5e8a\u8bd5\u9a8c<strong>\u5386\u65f612\u4e2a\u6708\uff0c\u7eb3\u516512\u540d\u75c5\u7a0b\u8d85\u8fc75\u5e74\u7684\u5e15\u91d1\u68ee\u75c5\u60a3\u8005<\/strong>\u3002\u901a\u8fc7\u7acb\u4f53\u5b9a\u5411\u624b\u672f\uff0c\u5c06\u7ec6\u80de\u7cbe\u786e\u79fb\u690d\u81f3\u60a3\u8005\u53cc\u4fa7\u58f3\u6838\u533a\u57df\uff0c\u5176\u4e2d\u4f4e\u5242\u91cf\u7ec4\uff08315\u4e07\u7ec6\u80de\uff09\u548c\u9ad8\u5242\u91cf\u7ec4\uff08630\u4e07\u7ec6\u80de\uff09\u54046\u4f8b\u3002<\/p>\n<p data-start=\"79\" data-end=\"175\">\u7814\u7a76\u6570\u636e\u663e\u793a\uff0c\u5e72\u7ec6\u80de\u79fb\u690d\u5728\u5b89\u5168\u6027\u65b9\u9762\u8868\u73b0\u826f\u597d\u3002\u6574\u4e2a\u8bd5\u9a8c\u4e2d\u4ec5\u51fa\u73b0\u5c11\u91cf\u8f7b\u5fae\u4e0d\u826f\u53cd\u5e94\uff0c\u591a\u4e0e\u514d\u75ab\u6291\u5236\u836f\u7269\u76f8\u5173\uff0c\u65e0\u4e25\u91cd\u5e76\u53d1\u75c7\u6216\u7ec6\u80de\u5f02\u5e38\u589e\u6b96\u3002\u5f71\u50cf\u5b66\u7ed3\u679c\u4e5f\u8bc1\u5b9e\uff0c\u79fb\u690d\u7ec6\u80de\u7cbe\u51c6\u5206\u5e03\uff0c\u65e0\u5f02\u5e38\u8fc1\u79fb\u6216\u80bf\u7624\u5f62\u6210\u3002<\/p>\n<p data-start=\"177\" data-end=\"306\"><strong>\u7597\u6548\u65b9\u9762\uff0c\u60a3\u8005\u5728\u672f\u540e12\u4e2a\u6708\u8fd0\u52a8\u529f\u80fd\u5e73\u5747\u63d0\u534714\u5206\u4ee5\u4e0a<\/strong>\uff0c\u9ad8\u5242\u91cf\u7ec4\u6548\u679c\u66f4\u4e3a\u663e\u8457\u3002\u65e5\u5e38\u6d3b\u52a8\u80fd\u529b\u3001\u751f\u6d3b\u8d28\u91cf\u53ca\u836f\u6548\u6301\u7eed\u65f6\u95f4\u5747\u6709\u660e\u663e\u6539\u5584\u3002\u5206\u5b50\u5f71\u50cf\u5b66\u8fdb\u4e00\u6b65\u9a8c\u8bc1\u4e86\u8fd9\u4e00\u53d8\u5316\uff1a\u79fb\u690d\u533a\u57df\u7684\u591a\u5df4\u80fa\u8f6c\u8fd0\u4f53\u6d3b\u6027\u663e\u8457\u589e\u5f3a\uff0c\u8bf4\u660e\u79fb\u690d\u7ec6\u80de\u6210\u529f\u6574\u5408\u8fdb\u795e\u7ecf\u7cfb\u7edf\uff0c\u90e8\u5206\u6062\u590d\u4e86\u591a\u5df4\u80fa\u901a\u8def\u529f\u80fd\u3002<\/p>\n<p data-start=\"308\" data-end=\"411\">\u7ec4\u7ec7\u5206\u6790\u663e\u793a\uff0c<strong>\u79fb\u690d\u7684\u7ec6\u80de\u5df2\u5728\u5bbf\u4e3b\u4f53\u5185\u5206\u5316\u4e3a\u6210\u719f\u7684\u591a\u5df4\u80fa\u795e\u7ecf\u5143\uff0c\u5e76\u4e0e\u539f\u6709\u795e\u7ecf\u7f51\u7edc\u5f62\u6210\u6709\u6548\u8fde\u63a5<\/strong>\u3002\u8fd9\u4e00\u7ed3\u679c\u6807\u5fd7\u7740\u4eba\u6e90\u80da\u80ce\u5e72\u7ec6\u80de\u884d\u751f\u7ec6\u80de\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\u7684\u5b89\u5168\u6027\u4e0e\u53ef\u884c\u6027\u5f97\u5230\u521d\u6b65\u9a8c\u8bc1\uff0c\u4e3a\u672a\u6765\u5927\u89c4\u6a21\u4e34\u5e8a\u5e94\u7528\u5960\u5b9a\u4e86\u57fa\u7840\u3002<\/p>\n<p>\u8be5\u7814\u7a76\u7684\u6700\u5927\u7a81\u7834\uff0c\u5728\u4e8e\u9996\u6b21\u7cfb\u7edf\u9a8c\u8bc1\u4e86<strong data-start=\"791\" data-end=\"820\">\u4eba\u80da\u80ce\u5e72\u7ec6\u80de\u884d\u751f\u795e\u7ecf\u5143\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\u7684\u53ef\u884c\u6027\u4e0e\u5b89\u5168\u6027<\/strong>\u3002\u4e0e\u8fc7\u53bb\u4f9d\u8d56\u80ce\u513f\u7ec4\u7ec7\u79fb\u690d\u4e0d\u540c\uff0c\u8fd9\u4e00\u65b9\u6848\u5728\u4f26\u7406\u3001\u6765\u6e90\u53ca\u751f\u4ea7\u6807\u51c6\u4e0a\u90fd\u5b9e\u73b0\u4e86\u7a81\u7834\u3002\u91c7\u7528\u65b0\u9c9c\u7ec6\u80de\u79fb\u690d\u7684\u7b56\u7565\uff0c\u4e5f\u6700\u5927\u9650\u5ea6\u5730\u4fdd\u7559\u4e86\u7ec6\u80de\u6d3b\u6027\u3002\u79d1\u5b66\u7684\u5242\u91cf\u8bbe\u8ba1\uff0c\u6e90\u81ea\u524d\u671f\u52a8\u7269\u5b9e\u9a8c\u7684\u79ef\u7d2f\uff0c\u4f7f\u5f97\u7597\u6548\u66f4\u5177\u53ef\u9760\u6027\u3002<\/p>\n<h3><span class=\"ez-toc-section\" id=\"2%E7%B3%96%E5%B0%BF%E7%97%85\"><\/span><strong>2.\u7cd6\u5c3f\u75c5<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u5bf9\u4e8e\u4f9d\u8d56\u80f0\u5c9b\u7d20\u6ce8\u5c04\u7684\u7cd6\u5c3f\u75c5\u60a3\u8005\uff0c\u591a\u80fd\u5e72\u7ec6\u80de\u7684\u76ee\u6807\u662f\u5b9e\u73b0\u201c\u4e00\u52b3\u6c38\u9038\u7684\u6cbb\u6108\u201d\u3002<\/p>\n<p data-start=\"139\" data-end=\"247\">2024\u5e749\u6708\uff0c\u300a<a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(25)01041-4?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867425010414%3Fshowall%3Dtrue\" target=\"_blank\" rel=\"nofollow noopener\">Cell\uff08\u7ec6\u80de\uff09<\/a>\u300b\u671f\u520a\u520a\u767b\u4e86\u4e00\u9879\u9707\u52a8\u5168\u7403\u7684\u6210\u679c\u2014\u2014\u7531\u5317\u4eac\u5927\u5b66\u9093\u5b8f\u9b41\u6559\u6388\u548c\u6c88\u4e2d\u9633\u6559\u6388\u56e2\u961f\u4e3b\u5bfc\u7684\u7814\u7a76\uff0c\u5229\u7528\u5316\u5b66\u91cd\u7f16\u7a0b\u5e72\u7ec6\u80de\uff08hCiPS\u7ec6\u80de\uff09\u6280\u672f\uff0c<strong>\u6210\u529f\u8ba9\u4e00\u540d1\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u5728\u79fb\u690d\u540e\u5b9e\u73b0\u201c\u529f\u80fd\u6027\u6cbb\u6108\u201d<\/strong>The<sup>[2]<\/sup><\/p>\n<p data-start=\"249\" data-end=\"415\">\u8fd9\u4f4d25\u5c81\u7684\u5929\u6d25\u5973\u6027\u60a3\u8005\u4ece14\u5c81\u8d77\u4fbf\u4f9d\u8d56\u80f0\u5c9b\u7d20\u751f\u6d3b\uff0c\u591a\u6b21\u63a5\u53d7\u809d\u810f\u548c\u80f0\u817a\u79fb\u690d\u5747\u672a\u6210\u529f\u30022023\u5e74\uff0c\u5979\u63a5\u53d7\u4e86\u7531\u81ea\u8eab\u7ec6\u80de\u8bf1\u5bfc\u751f\u6210\u7684\u80f0\u5c9b\u7ec6\u80de\u79fb\u690d\u3002<strong>\u672f\u540e75\u5929\uff0c\u5979\u7684\u8840\u7cd6\u6062\u590d\u7a33\u5b9a\uff0c\u80f0\u5c9b\u7d20\u5b8c\u5168\u505c\u7528\uff0c\u7cd6\u5316\u8840\u7ea2\u86cb\u767d\u964d\u81f3\u6b63\u5e38\u6c34\u5e73<\/strong>The<\/p>\n<p data-start=\"249\" data-end=\"415\">1\u5e74\u540e\uff0c\u60a3\u8005\u4ecd\u4fdd\u6301\u65e0\u80f0\u5c9b\u7d20\u4f9d\u8d56\u72b6\u6001\uff0c\u672a\u51fa\u73b0\u4efb\u4f55\u79fb\u690d\u76f8\u5173\u5e76\u53d1\u75c7\uff0c\u6807\u5fd7\u7740\u5316\u5b66\u91cd\u7f16\u7a0b\u5e72\u7ec6\u80de\u7597\u6cd5\u5728\u4eba\u7c7b\u7cd6\u5c3f\u75c5\u6cbb\u7597\u4e0a\u7684\u91cd\u5927\u7a81\u7834\u3002<\/p>\n<p data-start=\"249\" data-end=\"415\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-19884\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/537786b7-e412-4164-8e21-2c458d040fff.png\" alt=\"\u57281\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u8179\u90e8\u524d\u76f4\u808c\u9798\u4e0b\u79fb\u690d\u5316\u5b66\u8bf1\u5bfc\u7684\u591a\u80fd\u5e72\u7ec6\u80de\u884d\u751f\u7684\u80f0\u5c9b\" width=\"891\" height=\"182\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/537786b7-e412-4164-8e21-2c458d040fff.png 1150w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/537786b7-e412-4164-8e21-2c458d040fff-300x61.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/537786b7-e412-4164-8e21-2c458d040fff-1024x209.png 1024w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/537786b7-e412-4164-8e21-2c458d040fff-768x157.png 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/537786b7-e412-4164-8e21-2c458d040fff-18x4.png 18w\" sizes=\"(max-width: 891px) 100vw, 891px\" \/><\/p>\n<p data-start=\"452\" data-end=\"609\">2025\u5e74\uff0c\u9093\u5b8f\u9b41\u56e2\u961f\u5728\u300a<a href=\"https:\/\/www.nature.com\/articles\/s41589-024-01799-8\" target=\"_blank\" rel=\"nofollow noopener\">Nature<\/a>\u300b\u4e0a\u518d\u6b21\u53d1\u8868\u6700\u65b0\u7814\u7a76\uff0c\u63ed\u793a\u4e86\u5316\u5b66\u91cd\u7f16\u7a0b\u7684\u5173\u952e\u673a\u5236\u2014\u2014\u53d1\u73b0\u7ec4\u86cb\u767d\u4fee\u9970\u9176 <strong data-start=\"506\" data-end=\"525\">KAT3A\/B \u548c KAT6A<\/strong> \u662f\u9650\u5236\u7ec6\u80de\u91cd\u7f16\u7a0b\u6548\u7387\u7684\u4e3b\u8981\u201c\u8868\u89c2\u9057\u4f20\u969c\u788d\u201d\u3002\u901a\u8fc7\u9488\u5bf9\u6027\u6291\u5236\u8fd9\u4e9b\u9176\uff0c<strong>\u56e2\u961f\u6210\u529f\u5c06\u4eba\u6210\u4f53\u7ec6\u80de\u8f6c\u5316\u4e3a\u591a\u80fd\u5e72\u7ec6\u80de\u7684\u65f6\u95f4\uff0c\u4ece\u4f20\u7edf\u768430\u5929\u7f29\u77ed\u81f310\u5929\uff0c\u8bf1\u5bfc\u6548\u7387\u63d0\u534720\u500d\u4ee5\u4e0a<\/strong>The<sup>[3]<\/sup><\/p>\n<p data-start=\"611\" data-end=\"675\">\u8fd9\u4e00\u6210\u679c\u4e0d\u4ec5\u8ba9\u5e72\u7ec6\u80de\u5236\u5907\u66f4\u5feb\u3001\u66f4\u9ad8\u6548\uff0c\u4e5f\u4e3a\u4e2a\u6027\u5316\u7ec6\u80de\u6cbb\u7597\u63d0\u4f9b\u4e86\u66f4\u7a33\u5b9a\u3001\u4f4e\u6210\u672c\u7684\u7ec6\u80de\u6765\u6e90\uff0c\u63a8\u52a8\u5e72\u7ec6\u80de\u6280\u672f\u771f\u6b63\u8d70\u5411\u4e34\u5e8a\u53ef\u7528\u9636\u6bb5\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-19885 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/5c05526f-216f-4552-ad94-594d414844ee.png\" alt=\"\u4e00\u79cd\u5feb\u901f\u5316\u5b66\u91cd\u7f16\u7a0b\u7cfb\u7edf\u4ee5\u751f\u6210\u4eba\u7c7b\u591a\u80fd\u5e72\u7ec6\u80de\" width=\"667\" height=\"299\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/5c05526f-216f-4552-ad94-594d414844ee.png 667w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/5c05526f-216f-4552-ad94-594d414844ee-300x134.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/5c05526f-216f-4552-ad94-594d414844ee-18x8.png 18w\" sizes=\"(max-width: 667px) 100vw, 667px\" \/><\/p>\n<p data-start=\"715\" data-end=\"856\">2025\u5e748\u6708\uff0c\u5317\u4eac\u5927\u5b66\u9093\u5b8f\u9b41\u56e2\u961f\u53c8\u5728\u300a<a href=\"https:\/\/www.cell.com\/cell-stem-cell\/abstract\/S1934-5909(25)00263-2?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1934590925002632%3Fshowall%3Dtrue\" target=\"_blank\" rel=\"nofollow noopener\">Cell Stem Cell<\/a>\u300b\u53d1\u8868\u91cd\u78c5\u6210\u679c\u2014\u2014\u4ed6\u4eec\u9996\u6b21\u5229\u7528\u4eba\u591a\u80fd\u5e72\u7ec6\u80de\u6210\u529f\u6784\u5efa\u51fa<strong data-start=\"775\" data-end=\"800\">\u5177\u5907\u5b8c\u6574\u5185\u5206\u6ccc\u529f\u80fd\u7684\u4eba\u5de5\u80f0\u5c9b\uff08hiHIs\uff09<\/strong>\u3002\u8fd9\u4e9b\u4eba\u5de5\u80f0\u5c9b\u4e0d\u4ec5\u80fd\u5728\u9ad8\u8840\u7cd6\u65f6\u5206\u6ccc\u80f0\u5c9b\u7d20\u964d\u7cd6\uff0c\u8fd8\u80fd\u5728\u8840\u7cd6\u8fc7\u4f4e\u65f6\u5206\u6ccc\u80f0\u9ad8\u8840\u7cd6\u7d20\u201c\u62c9\u56de\u201d\u8840\u7cd6\uff0c\u5b9e\u73b0\u53cc\u5411\u7cbe\u51c6\u8c03\u8282\u3002<sup>[4]<\/sup><\/p>\n<p data-start=\"858\" data-end=\"950\">\u5728\u52a8\u7269\u5b9e\u9a8c\u4e2d\uff0c<strong>\u79fb\u690d\u4eba\u5de5\u80f0\u5c9b\u7684\u7cd6\u5c3f\u75c5\u5c0f\u9f20\u8840\u7cd6\u8fc5\u901f\u6062\u590d\u6b63\u5e38\uff0c\u4e14\u80fd\u81ea\u52a8\u8c03\u8282\u8840\u7cd6\u6ce2\u52a8\uff0c\u9632\u6b62\u4f4e\u8840\u7cd6\u53d1\u751f<\/strong>\u3002\u5176\u529f\u80fd\u51e0\u4e4e\u4e0e\u4eba\u4f53\u5929\u7136\u80f0\u5c9b\u65e0\u5f02\uff0c\u88ab\u8ba4\u4e3a\u662f\u8fc8\u5411\u4eba\u5de5\u80f0\u817a\u3001\u771f\u6b63\u201c\u6446\u8131\u80f0\u5c9b\u7d20\u4f9d\u8d56\u201d\u7684\u5173\u952e\u4e00\u6b65\u3002<\/p>\n<p data-start=\"858\" data-end=\"950\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-19886\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/c00af29d-a463-4908-9983-71e27cab3c49.png\" alt=\"\u5185\u5206\u6ccc\u4e9a\u578b\u5b8c\u6574\u4eba\u591a\u80fd\u5e72\u7ec6\u80de\u884d\u751f\u7684\u80f0\u5c9b\u5728\u4f53\u5185\u5177\u6709\u4f4e\u8840\u7cd6\u4fdd\u62a4\u80fd\u529b\u7684\u91cd\u5efa\" width=\"922\" height=\"182\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/c00af29d-a463-4908-9983-71e27cab3c49.png 1119w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/c00af29d-a463-4908-9983-71e27cab3c49-300x59.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/c00af29d-a463-4908-9983-71e27cab3c49-1024x202.png 1024w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/c00af29d-a463-4908-9983-71e27cab3c49-768x152.png 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/c00af29d-a463-4908-9983-71e27cab3c49-18x4.png 18w\" sizes=\"(max-width: 922px) 100vw, 922px\" \/><\/p>\n<h3><span class=\"ez-toc-section\" id=\"3%E8%A7%86%E7%BD%91%E8%86%9C%E9%80%80%E5%8C%96%E6%80%A7%E7%96%BE%E7%97%85\"><\/span><strong>3.\u89c6\u7f51\u819c\u9000\u5316\u6027\u75be\u75c5<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2468653019300909?via%3Dihub\" target=\"_blank\" rel=\"nofollow noopener\">\u65e5\u672c\u7406\u5316\u5b66\u7814\u7a76\u6240<\/a>\uff08RIKEN\uff09\u5f00\u5c55\u7684\u5168\u7403\u9996\u4f8b\u81ea\u4f53\u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de\uff08iPSC\uff09\u884d\u751f\u89c6\u7f51\u819c\u8272\u7d20\u4e0a\u76ae\uff08RPE\uff09\u79fb\u690d\u4e34\u5e8a\u7814\u7a76\uff0c\u662fiPSC\u6cbb\u7597\u8fc8\u5411\u4e34\u5e8a\u7684\u91cd\u8981\u7a81\u7834\u3002\u7814\u7a76\u56e2\u961f\u5c06\u60a3\u8005\u81ea\u8eab\u76ae\u80a4\u7ec6\u80de\u91cd\u7f16\u7a0b\u4e3aiPSC\uff0c\u518d\u5206\u5316\u4e3aRPE\u7ec6\u80de\u79fb\u690d\u5165\u9ec4\u6591\u53d8\u6027\u60a3\u8005\u773c\u5185\u3002<sup>[5]<\/sup><\/p>\n<p>\u7ed3\u679c\u663e\u793a\uff0c<strong>\u79fb\u690d4\u5e74\u7684\u7ec6\u80de\u5728\u4f53\u5185\u957f\u671f\u7a33\u5b9a\u5b58\u6d3b\uff0c\u65e0\u660e\u663e\u514d\u75ab\u6392\u65a5\u6216\u80bf\u7624\u98ce\u9669\uff0c\u90e8\u5206\u60a3\u8005\u89c6\u529b\u5f97\u5230\u6539\u5584\u6216\u4fdd\u6301\u7a33\u5b9a<\/strong>\u3002\u8be5\u7814\u7a76\u9996\u6b21\u8bc1\u5b9e\u4e86iPSC\u5728\u4eba\u4f53\u5185\u5b89\u5168\u53ef\u884c\uff0c\u4e3a\u672a\u6765\u57fa\u4e8e\u591a\u80fd\u5e72\u7ec6\u80de\u7684\u518d\u751f\u533b\u5b66\u5960\u5b9a\u4e86\u4e34\u5e8a\u57fa\u7840\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-19889 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/ScreenShot_2025-10-22_160506_126.png\" alt=\"\u81ea\u4f53\u8bf1\u5bfc\u6027\u591a\u80fd\u5e72\u7ec6\u80de\u6765\u6e90\u7684\u89c6\u7f51\u819c\u8272\u7d20\u4e0a\u76ae\u79fb\u690d\u6cbb\u7597\u6e17\u51fa\u6027\u5e74\u9f84\u76f8\u5173\u6027\u9ec4\u6591\u53d8\u6027\u7684\u6548\u679c\u8bc4\u4ef7\" width=\"627\" height=\"616\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/ScreenShot_2025-10-22_160506_126.png 627w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/ScreenShot_2025-10-22_160506_126-300x295.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/ScreenShot_2025-10-22_160506_126-12x12.png 12w\" sizes=\"(max-width: 627px) 100vw, 627px\" \/><\/p>\n<h3><span class=\"ez-toc-section\" id=\"4%E8%84%8A%E9%AB%93%E6%8D%9F%E4%BC%A4\"><\/span><strong>4.\u810a\u9ad3\u635f\u4f24<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>2025\u5e747\u67082\u65e5\uff0c<strong>\u5168\u7403\u9996\u4e2a\u9776\u5411\u810a\u9ad3\u635f\u4f24\u7684\u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de\uff08iPSC\uff09\u884d\u751f\u4e9a\u578b\u795e\u7ecf\u7ec6\u80deI\u7c7b\u65b0\u836fI\/II\u671f\u4e34\u5e8a\u7814\u7a76\u542f\u52a8\u4f1a<\/strong>\uff0c\u5728\u5927\u8fde\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u7b2c\u4e00\u533b\u9662\u4e0e\u4e2d\u5c71\u5927\u5b66\u9644\u5c5e\u7b2c\u4e09\u533b\u9662\u540c\u6b65\u542f\u5e55\u3002<sup>[6]<\/sup><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-19891 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/ScreenShot_2025-10-22_161106_820.png\" alt=\"\u5168\u7403\u9996\u4e2a\u9776\u5411\u810a\u9ad3\u635f\u4f24\u7684\u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de\uff08iPSC\uff09\u884d\u751f\u4e9a\u578b\u795e\u7ecf\u7ec6\u80deI\u7c7b\u65b0\u836fI\/II\u671f\u4e34\u5e8a\u7814\u7a76\u542f\u52a8\u4f1a\" width=\"671\" height=\"423\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/ScreenShot_2025-10-22_161106_820.png 671w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/ScreenShot_2025-10-22_161106_820-300x189.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/ScreenShot_2025-10-22_161106_820-18x12.png 18w\" sizes=\"(max-width: 671px) 100vw, 671px\" \/><\/p>\n<p>2025\u5e745\u6708\uff0c\u8fd9\u9879\u5168\u7403\u9996\u4e2a\u5f02\u4f53\u901a\u7528\u578b\u201c\u73b0\u8d27\u578b\u201diPSC\u884d\u751f\u4e9a\u578b\u795e\u7ecf\u7ec6\u80de\u65b0\u836f\u6ce8\u518c\u4e34\u5e8a\u8bd5\u9a8c\uff0c<strong>\u4e00\u6b21\u6027\u6210\u529f\u901a\u8fc7\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u4e0e\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u7684\u5ba1\u6279\uff08\u4e2d\u7f8e\u53cc\u62a5\uff09<\/strong>\uff0c\u4e14\u5747\u83b7\u201c\u65e0\u53d1\u8865\u5b8c\u5168\u6279\u51c6\u201d\u3002\u8be5\u836f\u7269\u4f5c\u4e3a\u5168\u7403\u9996\u6b3e\u9776\u5411\u518d\u751f\u810a\u9ad3\u533a\u7684\u4e9a\u578b\u7279\u5316\u795e\u7ecf\u524d\u4f53\u7ec6\u80de\u65b0\u836f\uff0c\u5c06\u7528\u4e8e\u6cbb\u7597\u810a\u9ad3\u635f\u4f24\u8fd9\u4e00\u4e16\u754c\u6027\u533b\u5b66\u96be\u9898\u3002<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%E4%B8%89%E3%80%81%E7%96%97%E6%95%88%E5%BD%B1%E5%93%8D%E5%9B%A0%E7%B4%A0%EF%BC%9A%E4%B8%8D%E6%98%AF%E6%89%80%E6%9C%89%E6%82%A3%E8%80%85%E6%95%88%E6%9E%9C%E9%83%BD%E4%B8%80%E6%A0%B7\"><\/span><strong>\u4e09\u3001\u7597\u6548\u5f71\u54cd\u56e0\u7d20\uff1a\u4e0d\u662f\u6240\u6709\u60a3\u8005\u6548\u679c\u90fd\u4e00\u6837<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p data-start=\"1103\" data-end=\"1157\">\u591a\u80fd\u5e72\u7ec6\u80de\u6cbb\u7597\u7684\u6548\u679c\u5e76\u975e\u4e00\u6210\u4e0d\u53d8\uff0c\u76ee\u524d\u7684\u7814\u7a76\u663e\u793a\uff0c\u5b83\u53d7\u5230\u4ee5\u4e0b\u51e0\u4e2a\u5173\u952e\u56e0\u7d20\u7684\u5171\u540c\u5f71\u54cd\uff1a<\/p>\n<ul data-start=\"1159\" data-end=\"1308\">\n<li data-start=\"1159\" data-end=\"1201\">\n<p data-start=\"1161\" data-end=\"1201\"><strong data-start=\"1161\" data-end=\"1174\">\u7ec6\u80de\u6765\u6e90\u4e0e\u5206\u5316\u8d28\u91cf<\/strong>\uff1a\u7ec6\u80de\u7684\u7eaf\u5ea6\u3001\u6210\u719f\u5ea6\u53ca\u529f\u80fd\u7a33\u5b9a\u6027\u76f4\u63a5\u5f71\u54cd\u4fee\u590d\u6548\u679c\uff1b<\/p>\n<\/li>\n<li data-start=\"1202\" data-end=\"1229\">\n<p data-start=\"1204\" data-end=\"1229\"><strong data-start=\"1204\" data-end=\"1212\">\u75c5\u60c5\u9636\u6bb5<\/strong>\uff1a\u65e9\u671f\u5e72\u9884\u901a\u5e38\u6bd4\u665a\u671f\u6548\u679c\u66f4\u597d\uff1b<\/p>\n<\/li>\n<li data-start=\"1230\" data-end=\"1270\">\n<p data-start=\"1232\" data-end=\"1270\"><strong data-start=\"1232\" data-end=\"1240\">\u7ed9\u836f\u9014\u5f84<\/strong>\uff1a\u4e0d\u540c\u7684\u75be\u75c5\u53ef\u80fd\u9700\u91c7\u7528\u9759\u8109\u6ce8\u5c04\u3001\u5c40\u90e8\u6ce8\u5c04\u6216\u7acb\u4f53\u5b9a\u5411\u690d\u5165\uff1b<\/p>\n<\/li>\n<li data-start=\"1271\" data-end=\"1308\">\n<p data-start=\"1273\" data-end=\"1308\"><strong data-start=\"1273\" data-end=\"1286\">\u60a3\u8005\u4f53\u8d28\u4e0e\u514d\u75ab\u72b6\u6001<\/strong>\uff1a\u826f\u597d\u7684\u514d\u75ab\u73af\u5883\u66f4\u6709\u5229\u4e8e\u7ec6\u80de\u5b58\u6d3b\u4e0e\u6574\u5408\u3002<\/p>\n<\/li>\n<\/ul>\n<p data-start=\"1310\" data-end=\"1355\">\u56e0\u6b64\uff0c\u5e72\u7ec6\u80de\u6cbb\u7597\u5e76\u975e\u201c\u7acb\u7aff\u89c1\u5f71\u201d\uff0c\u800c\u662f\u4e00\u4e2a\u5faa\u5e8f\u6e10\u8fdb\u7684\u8fc7\u7a0b\uff0c\u901a\u5e38\u9700\u8981\u6570\u5468\u5230\u6570\u6708\u89c2\u5bdf\u7597\u6548\u53d8\u5316\u3002<\/p>\n<h2 data-start=\"1103\" data-end=\"1157\"><span class=\"ez-toc-section\" id=\"%E5%9B%9B%E3%80%81%E6%9C%AA%E6%9D%A5%E5%B1%95%E6%9C%9B%E4%B8%8E%E6%8C%91%E6%88%98\"><\/span><strong>\u56db\u3001\u672a\u6765\u5c55\u671b\u4e0e\u6311\u6218<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>\u5c3d\u7ba1\u53d6\u5f97\u4e86\u4ee4\u4eba\u9f13\u821e\u7684\u8fdb\u5c55\uff0c\u591a\u80fd\u5e72\u7ec6\u80de\u6cbb\u7597\u771f\u6b63\u6210\u4e3a\u5e38\u89c4\u4e34\u5e8a\u5e94\u7528\u4ecd\u9762\u4e34\u6311\u6218\u548c\u672a\u6765\u53d1\u5c55\u7684\u65b9\u5411\uff1a<\/p>\n<p>\u6700\u5927\u7684\u95ee\u9898\u5728\u4e8e\u81f4\u7624\u6027\u98ce\u9669\uff0c\u9700\u6301\u7eed\u4f18\u5316\u7eaf\u5316\u4e0e\u76d1\u6d4b\u6280\u672f\uff1b\u5176\u6b21\u662f\u514d\u75ab\u6392\u65a5\u53cd\u5e94\uff0c\u5373\u4fbf\u81ea\u4f53\u6765\u6e90\u7684iPSCs\u4e5f\u53ef\u80fd\u5f15\u53d1\u514d\u75ab\u53cd\u5e94\uff0c\u800c\u5f02\u4f53\u79fb\u690d\u5219\u4f9d\u8d56\u914d\u578b\u6216\u514d\u75ab\u6291\u5236\uff0c\u672a\u6765\u5efa\u7acb\u901a\u7528\u578biPSC\u5e93\u5c06\u662f\u5173\u952e\u65b9\u5411\u3002<\/p>\n<p>\u6b64\u5916\uff0c\u5236\u5907\u6807\u51c6\u5316\u548c\u6210\u672c\u63a7\u5236\u4ecd\u662f\u63a8\u5e7f\u74f6\u9888\u3002\u672a\u6765\u7684\u53d1\u5c55\u8d8b\u52bf\u5305\u62ec\u7ed3\u5408\u57fa\u56e0\u7f16\u8f91\u4ee5\u6839\u6cbb\u9057\u4f20\u6027\u75be\u75c5\uff0c\u878d\u5408\u751f\u7269\u6750\u6599\u6784\u5efa\u590d\u6742\u7ec4\u7ec7\u5668\u5b98\uff0c\u4ee5\u53ca\u5f00\u5c55\u66f4\u5927\u89c4\u6a21\u3001\u957f\u671f\u7684\u2162\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u4ee5\u5168\u9762\u9a8c\u8bc1\u7597\u6548\u4e0e\u5b89\u5168\u6027\u3002<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%E7%BB%93%E8%AF%AD\"><\/span><strong>concluding remarks<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p data-start=\"1595\" data-end=\"1695\">\u603b\u4f53\u6765\u770b\uff0c\u591a\u80fd\u5e72\u7ec6\u80de\u6cbb\u7597\u7684\u7597\u6548\u6b63\u5728\u4ece\u5b9e\u9a8c\u9a8c\u8bc1\u8d70\u5411\u4e34\u5e8a\u8bc1\u636e\u3002\u5728\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u3001\u7cd6\u5c3f\u75c5\u3001\u5fc3\u810f\u4fee\u590d\u3001\u89c6\u7f51\u819c\u75c5\u53d8\u7b49\u9886\u57df\uff0c\u90fd\u5df2\u7ecf\u6709\u4e86\u521d\u6b65\u6210\u529f\u7684\u6848\u4f8b\u3002\u867d\u7136\u79bb\u201c\u5168\u9762\u5e94\u7528\u201d\u4ecd\u9700\u65f6\u95f4\uff0c\u4f46\u5b83\u6b63\u5728\u91cd\u5851\u518d\u751f\u533b\u5b66\u7684\u672a\u6765\u3002<\/p>\n<p data-start=\"1697\" data-end=\"1769\">\u591a\u80fd\u5e72\u7ec6\u80de\u5e76\u975e\u201c\u4e07\u80fd\u836f\u201d\uff0c\u5374\u53ef\u80fd\u6210\u4e3a\u8bb8\u591a\u7591\u96be\u75be\u75c5\u6cbb\u7597\u7684\u65b0\u8d77\u70b9\u3002\u968f\u7740\u6280\u672f\u6210\u719f\u4e0e\u76d1\u7ba1\u5b8c\u5584\uff0c\u672a\u6765\u5341\u5e74\uff0c\u6216\u8bb8\u6211\u4eec\u5c06\u771f\u6b63\u89c1\u8bc1\u201c\u8ba9\u8eab\u4f53\u81ea\u6211\u518d\u751f\u201d\u7684\u533b\u5b66\u5947\u8ff9\u3002<\/p>\n<blockquote><p>References:<\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">[1]\u4eba\u7c7b\u80da\u80ce\u5e72\u7ec6\u80de\u884d\u751f\u7684\u591a\u5df4\u80fa\u7956\u7ec6\u80de\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\u76841\/2a\u671f\u4e34\u5e8a\u8bd5\u9a8cChang, Jin Woo et al. Cell, Volume 0, Issue 0<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">[2]\u738bS\uff0c\u675cY\uff0c\u5f20B\uff0c\u5b5fG\uff0c\u5218Z\uff0c\u5218SY\uff0c\u6881R\uff0c\u5f20Z\uff0c\u8521X\uff0c\u5434S\uff0c\u9ad8W\uff0c\u5e84D\uff0c\u90b9J\uff0c\u9ec4H\uff0c\u738bM\uff0c\u738bX\uff0c\u738bX\uff0c\u6881T\uff0c\u5218T\uff0c\u987eJ\uff0c\u5218N\uff0c\u9b4fY\uff0c\u4e01X\uff0c\u6d66Y\uff0c\u8a79Y\uff0cY\uff0cY\uff0cY\uff0cY\uff0cY\uff0c\u6768\uff0cY\u7fc1Y\uff0c\u5468C\uff0c\u738bZ\uff0c\u738bS\uff0c\u9093H\uff0c\u6c89Z. \u5728 1 \u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u8179\u524d\u76f4\u808c\u9798\u4e0b\u79fb\u690d\u5316\u5b66\u8bf1\u5bfc\u7684\u591a\u80fd\u5e72\u7ec6\u80de\u6765\u6e90\u7684\u80f0\u5c9b\u3002\u7ec6\u80de\u3002 2024 \u5e74 10 \u6708 31 \u65e5\uff1b187(22):6152-6164.e18\u3002 doi\uff1a10.1016\/j.cell.2024.09.004\u3002\u7535\u5b50\u7248 2024 \u5e74 9 \u6708 25 \u65e5\u3002PMID\uff1a39326417\u3002<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">[3]Wang Y\uff0cPeng F\uff0cYang Z\uff0cCheng L\uff0cCao J\uff0cFu X\uff0cHe H\uff0cCai R\uff0cZeng W\uff0cDong Y\uff0cChen G\uff0cPeng G\uff0cLiuyang S\uff0cWang G\uff0cWang J\uff0cMu R\uff0cLi C\uff0cGuan J\uff0cDeng H\u3002\u4e00\u79cd\u4ea7\u751f\u4eba\u7c7b\u591a\u80fd\u5e72\u7ec6\u80de\u7684\u5feb\u901f\u5316\u5b66\u91cd\u7f16\u7a0b\u7cfb\u7edf\u3002\u81ea\u7136\u5316\u5b66\u751f\u7269\u3002 2025 \u5e74 7 \u6708\uff1b21(7):1030-1038\u3002 DOI\uff1a10.1038\/s41589-024-01799-8\u3002 Epub 2025 \u5e74 1 \u6708 3 \u65e5\u3002PMID\uff1a39753706\u3002<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">[4]\u5b5f\u521a\uff0c\u987e\u5efa\uff0c\u5218\u80dc\u4e49\uff0c\u66f9\u5efa\uff0c\u738b\u54f2\uff0c\u9a6c\u6668\uff0c\u4ed8\u54f2\uff0c\u5468\u534e\uff0c\u738b\u5efa\uff0c\u738b\u80dc\uff0c\u8346\u80dc\uff0c\u5434\u71d5\uff0c\u96f7\u54f2\uff0c\u652f\u80dc\uff0c\u4f55\u71d5\uff0c\u674e\u6668\uff0c\u9093\u534e\u3002\u91cd\u5efa\u5185\u5206\u6ccc\u4e9a\u578b-\u5b8c\u5168\u4eba\u7c7b\u591a\u80fd\u5e72\u7ec6\u80de\u6765\u6e90\u7684\u80f0\u5c9b\u53ca\u5176\u5728\u4f53\u5185\u4f4e\u8840\u7cd6\u4fdd\u62a4\u80fd\u529b\u3002\u300a\u7ec6\u80de\u5e72\u7ec6\u80de\u300b\u30022025\u5e749\u67084\u65e5;32(9):1438-1456.e7\u3002doi: 10.1016\/j.stem.2025.07.006\u3002\u7535\u5b50\u7248\u53d1\u5e03\u65e5\u671f\uff1a2025\u5e748\u67088\u65e5\u3002PMID: 40782792\u3002<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">[5]Takagi S, Mandai M, Gocho K, Hirami Y, Yamamoto M, Fujihara M, Sugita S, Kurimoto Y, Takahashi M. \u79fb\u690d\u81ea\u4f53\u8bf1\u5bfc\u6027\u591a\u80fd\u5e72\u7ec6\u80de\u6765\u6e90\u7684\u89c6\u7f51\u819c\u8272\u7d20\u4e0a\u76ae\u5728\u6e17\u51fa\u6027\u5e74\u9f84\u76f8\u5173\u6027\u9ec4\u6591\u53d8\u6027\u4e2d\u7684\u8bc4\u4f30\u3002\u300a\u773c\u79d1\u89c6\u7f51\u819c\u300b2019\u5e7410\u6708;3(10):850-859\u3002doi: 10.1016\/j.oret.2019.04.021\u3002\u7535\u5b50\u7248\u53d1\u5e03\u65e5\u671f\uff1a2019\u5e744\u670826\u65e5\u3002PMID\uff1a31248784\u3002<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">[6]https:\/\/mp.weixin.qq.com\/s\/rRXzz6ZusVCnfHiRUz5qLg<\/span><\/span><\/p>\n<p>Disclaimer: This article is intended only to disseminate scientific knowledge and share industry perspectives, and does not constitute any clinical diagnostic advice! The information published by Hangi Stem Cells is not a substitute for the professional advice of a physician or pharmacist. If you have any questions about copyright or other issues, please feel free to contact me.<\/p><\/blockquote>","protected":false},"excerpt":{"rendered":"<p>\u591a\u80fd\u5e72\u7ec6\u80de\u6cbb\u7597\u6548\u679c\u5982\u4f55\uff1f\u672c\u6587\u6df1\u5165\u89e3\u6790\u591a\u80fd\u5e72\u7ec6\u80de\uff08ESCs\/iPSCs\uff09\u5728\u5e15\u91d1\u68ee\u75c5\u3001\u7cd6\u5c3f\u75c5\u3001\u89c6\u7f51\u819c\u9000\u5316\u53ca\u810a\u9ad3\u635f\u4f24\u7b49\u9886\u57df\u7684\u4e34\u5e8a\u5e94\u7528\u8fdb\u5c55\u3002\u4ece\u539f\u7406\u3001\u5206\u5316\u673a\u5236\u5230\u6700\u65b0\u4e34\u5e8a\u6848\u4f8b\uff0c\u5168\u9762\u5c55\u793a\u5e72\u7ec6\u80de\u79fb\u690d\u540e\u7684\u5b89\u5168\u6027\u3001\u529f\u80fd\u6062\u590d\u53ca\u7597\u6548\u6570\u636e\uff0c\u5e2e\u52a9\u8bfb\u8005\u4e86\u89e3\u591a\u80fd\u5e72\u7ec6\u80de\u6cbb\u7597\u7684\u771f\u5b9e\u6548\u679c\u548c\u672a\u6765\u53d1\u5c55\u8d8b\u52bf\uff0c\u4e3a\u518d\u751f\u533b\u5b66\u7814\u7a76\u548c\u4e34\u5e8a\u8f6c\u5316\u63d0\u4f9b\u6743\u5a01\u53c2\u8003\u3002<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[75],"tags":[193,172],"_links":{"self":[{"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/posts\/19877"}],"collection":[{"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/comments?post=19877"}],"version-history":[{"count":2,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/posts\/19877\/revisions"}],"predecessor-version":[{"id":19895,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/posts\/19877\/revisions\/19895"}],"wp:attachment":[{"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/media?parent=19877"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/categories?post=19877"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/tags?post=19877"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}