{"id":20208,"date":"2025-10-30T14:29:37","date_gmt":"2025-10-30T06:29:37","guid":{"rendered":"https:\/\/www.hjtdsm.cn\/?p=20208"},"modified":"2025-10-30T14:29:37","modified_gmt":"2025-10-30T06:29:37","slug":"%e9%97%b4%e5%85%85%e8%b4%a8%e5%b9%b2%e7%bb%86%e8%83%9e%e6%b2%bb%e7%96%97%e7%b3%96%e5%b0%bf%e7%97%85%ef%bc%9a%e6%98%af%e7%90%86%e6%83%b3%e5%80%99%e9%80%89%e7%96%97%e6%b3%95%e5%90%97%ef%bc%9f","status":"publish","type":"post","link":"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/mscs\/20208.html","title":{"rendered":"\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6cbb\u7597\u7cd6\u5c3f\u75c5\uff1a\u662f\u7406\u60f3\u5019\u9009\u7597\u6cd5\u5417\uff1f"},"content":{"rendered":"<p><span dir=\"auto\">\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09\u662f\u6210\u4f53\u5e72\u7ec6\u80de\uff08ASCs\uff09\uff0c\u5177\u6709\u4fee\u590d\u53d7\u635f\u7ec6\u80de\u3001\u53d1\u6325\u6297\u708e\u53cd\u5e94\u548c\u4ea7\u751f\u514d\u75ab\u8c03\u8282\u4f5c\u7528\u7b49\u7279\u6027\uff0c\u5e76\u80fd\u663e\u8457\u8bf1\u5bfc\u5206\u5316\u4e3a\u80f0\u5c9b\u7d20\u5206\u6ccc\u7ec6\u80de\uff08IPCs\uff09\uff0c\u4ece\u800c\u4e3a\u7ec6\u80de\u66ff\u4ee3\u7597\u6cd5\u548c\u7cd6\u5c3f\u75c5\u75be\u75c5\u6a21\u578b\u63d0\u4f9b\u6e90\u6e90\u4e0d\u65ad\u7684<\/span><span dir=\"auto\">\u03b2<\/span><span dir=\"auto\">\u7ec6\u80de\u3002\u9274\u4e8e\u8fd9\u4e9b\u663e\u8457\u4f18\u52bf\uff0cMSC\u7597\u6cd5\u53ef\u80fd\u662f\u6cbb\u7597\u7cd6\u5c3f\u75c5\u6700\u6709\u524d\u666f\u7684\u7b56\u7565\u3002<a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2021\/9938658\" target=\"_blank\" rel=\"noopener nofollow\">\u672c\u6587\u91cd\u70b9\u63a2\u8ba8\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6cbb\u7597\u7cd6\u5c3f\u75c5\uff1a\u662f\u7406\u60f3\u5019\u9009\u7597\u6cd5\u5417<\/a>\uff1f<\/span><\/p>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_79_2 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewbox=\"0 0 24 24\" version=\"1.2\" baseprofile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/mscs\/20208.html\/#%E9%97%B4%E5%85%85%E8%B4%A8%E5%B9%B2%E7%BB%86%E8%83%9E%EF%BC%9A%E6%B2%BB%E7%96%97%E7%B3%96%E5%B0%BF%E7%97%85%E7%9A%84%E7%90%86%E6%83%B3%E5%80%99%E9%80%89%E7%96%97%E6%B3%95\" >\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff1a\u6cbb\u7597\u7cd6\u5c3f\u75c5\u7684\u7406\u60f3\u5019\u9009\u7597\u6cd5<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/mscs\/20208.html\/#%E4%B8%80%E3%80%81IPCs%E7%A7%BB%E6%A4%8D\" >\u4e00\u3001IPCs\u79fb\u690d<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/mscs\/20208.html\/#2%E3%80%81%E4%B8%B4%E5%BA%8A%E9%97%B4%E5%85%85%E8%B4%A8%E5%B9%B2%E7%BB%86%E8%83%9E%E7%A7%BB%E6%A4%8D%E6%B2%BB%E7%96%97%E7%B3%96%E5%B0%BF%E7%97%85\" >2\u3001\u4e34\u5e8a\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u79fb\u690d\u6cbb\u7597\u7cd6\u5c3f\u75c5<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/mscs\/20208.html\/#21_MSCs%E6%B2%BB%E7%96%971%E5%9E%8B%E7%B3%96%E5%B0%BF%E7%97%85%E7%9A%84%E4%B8%B4%E5%BA%8A%E7%A0%94%E7%A9%B6\" >2.1. MSCs\u6cbb\u75971\u578b\u7cd6\u5c3f\u75c5\u7684\u4e34\u5e8a\u7814\u7a76<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/mscs\/20208.html\/#22_MSC%E7%96%97%E6%B3%95%E6%B2%BB%E7%96%972%E5%9E%8B%E7%B3%96%E5%B0%BF%E7%97%85%E7%9A%84%E4%B8%B4%E5%BA%8A%E7%A0%94%E7%A9%B6\" >2.2. MSC\u7597\u6cd5\u6cbb\u75972\u578b\u7cd6\u5c3f\u75c5\u7684\u4e34\u5e8a\u7814\u7a76<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/mscs\/20208.html\/#%E4%B8%89%E3%80%81%E9%97%B4%E5%85%85%E8%B4%A8%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E7%B3%96%E5%B0%BF%E7%97%85%E7%9A%84%E4%BD%9C%E7%94%A8%E6%9C%BA%E5%88%B6\" >\u4e09\u3001\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6cbb\u7597\u7cd6\u5c3f\u75c5\u7684\u4f5c\u7528\u673a\u5236<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/mscs\/20208.html\/#%E7%9B%B4%E6%8E%A5%E4%BD%9C%E7%94%A8%E4%B8%8E%E6%A0%B9%E6%9C%AC%E7%9B%AE%E6%A0%87%E2%80%94%E2%80%94%E6%9B%BF%E4%BB%A3%E4%B8%8E%E4%BF%AE%E5%A4%8D%CE%B2%E7%BB%86%E8%83%9E\" >\u76f4\u63a5\u4f5c\u7528\u4e0e\u6839\u672c\u76ee\u6807\u2014\u2014\u66ff\u4ee3\u4e0e\u4fee\u590d\u03b2\u7ec6\u80de<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/mscs\/20208.html\/#%E9%97%B4%E6%8E%A5%E4%BD%9C%E7%94%A8%E4%B8%8E%E5%8D%8F%E5%90%8C%E5%A2%9E%E6%95%88%E2%80%94%E2%80%94%E6%94%B9%E5%96%84%E7%8E%AF%E5%A2%83%E4%B8%8E%E8%B0%83%E8%8A%82%E5%85%8D%E7%96%AB\" >\u95f4\u63a5\u4f5c\u7528\u4e0e\u534f\u540c\u589e\u6548\u2014\u2014\u6539\u5584\u73af\u5883\u4e0e\u8c03\u8282\u514d\u75ab<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/mscs\/20208.html\/#%E5%9B%9B%E3%80%81%E6%80%BB%E7%BB%93%E6%A0%B8%E5%BF%83%E6%B2%BB%E7%96%97%E6%BD%9C%E5%8A%9B%E4%B8%8E%E6%9C%BA%E5%88%B6\" >\u56db\u3001\u603b\u7ed3\u6838\u5fc3\u6cbb\u7597\u6f5c\u529b\u4e0e\u673a\u5236<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/mscs\/20208.html\/#%E8%BE%A8%E6%9E%90%E5%BD%93%E5%89%8D%E9%9D%A2%E4%B8%B4%E7%9A%84%E4%B8%B4%E5%BA%8A%E9%80%89%E6%8B%A9%E4%B8%8E%E6%8C%91%E6%88%98\" >\u8fa8\u6790\u5f53\u524d\u9762\u4e34\u7684\u4e34\u5e8a\u9009\u62e9\u4e0e\u6311\u6218<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/mscs\/20208.html\/#%E6%8C%87%E6%98%8E%E6%9C%AA%E6%9D%A5%E5%8F%91%E5%B1%95%E6%96%B9%E5%90%91%E4%B8%8E%E8%A6%81%E6%B1%82\" >\u6307\u660e\u672a\u6765\u53d1\u5c55\u65b9\u5411\u4e0e\u8981\u6c42<\/a><\/li><\/ul><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"%E9%97%B4%E5%85%85%E8%B4%A8%E5%B9%B2%E7%BB%86%E8%83%9E%EF%BC%9A%E6%B2%BB%E7%96%97%E7%B3%96%E5%B0%BF%E7%97%85%E7%9A%84%E7%90%86%E6%83%B3%E5%80%99%E9%80%89%E7%96%97%E6%B3%95\"><\/span>\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff1a\u6cbb\u7597\u7cd6\u5c3f\u75c5\u7684\u7406\u60f3\u5019\u9009\u7597\u6cd5<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span dir=\"auto\"><a href=\"https:\/\/www.hjtdsm.cn\/en\/research\/es\/diabetes\/20123.html\/\" target=\"_blank\" rel=\"noopener\">\u7cd6\u5c3f\u75c5\uff08DM\uff09<\/a>\u662f\u4e00\u7ec4\u4ee3\u8c22\u6027\u75be\u75c5\uff0c\u5176\u7279\u5f81\u662f\u7531\u4e8e\u80f0\u817a\u6fc0\u7d20\u80f0\u5c9b\u7d20\u5206\u6ccc\u4e0d\u8db3\u6216\u529f\u80fd\u969c\u788d\u5bfc\u81f4\u8461\u8404\u7cd6\u4ee3\u8c22\u7d0a\u4e71\uff0c\u6700\u7ec8\u5f15\u53d1\u4e00\u7cfb\u5217\u4e25\u91cd\u7684\u5e76\u53d1\u75c7\uff0c\u5e76\u5df2\u6210\u4e3a\u5168\u7403\u6d41\u884c\u75c5\uff0c\u53d1\u75c5\u7387\u6025\u5267\u4e0a\u5347\u3002\u7cd6\u5c3f\u75c5\u901a\u5e38\u5206\u4e3a\u4e24\u5927\u7c7b\uff1a1\u578b\u7cd6\u5c3f\u75c5\uff08T1DM\uff09\u548c2\u578b\u7cd6\u5c3f\u75c5\uff08T2DM\uff09\u3002T1DM\u7684\u7279\u5f81\u662f\u80f0\u5c9b\u03b2\u7ec6\u80de\u81ea\u8eab\u514d\u75ab\u6027\u7834\u574f\uff0c<\/span><span dir=\"auto\">\u5bfc\u81f4<\/span><span dir=\"auto\">\u4e25\u91cd\u7684\u80f0\u5c9b\u7d20\u7f3a\u4e4f<\/span><span dir=\"auto\">\uff1b\u800cT2DM\u5219\u662f\u7531\u80f0\u5c9b\u7d20\u62b5\u6297\u548c\u80f0\u5c9b\u03b2<\/span><span dir=\"auto\">\u7ec6\u80de\u529f\u80fd\u969c\u788d\u5171\u540c\u5bfc\u81f4\u7684<\/span><span dir=\"auto\">\u3002\u5c3d\u7ba1\u5305\u62ec\u53e3\u670d\u964d\u7cd6\u836f\u548c\u5916\u6e90\u6027\u80f0\u5c9b\u7d20\u6ce8\u5c04\u5728\u5185\u7684\u5e38\u89c4\u6cbb\u7597\u65b9\u6cd5\u53ef\u4ee5\u6539\u5584\u9ad8\u8840\u7cd6\u76f8\u5173\u75c7\u72b6\u6216\u6682\u65f6\u63d0\u9ad8\u9776\u7ec4\u7ec7\u7684\u80f0\u5c9b\u7d20\u654f\u611f\u6027\uff0c\u4f46\u8fd9\u4e9b\u6cbb\u7597\u65b9\u6cd5\u65e2\u4e0d\u80fd\u9006\u8f6c\u75be\u75c5\u8fdb\u5c55\uff0c\u4e5f\u4e0d\u80fd\u4fee\u590d\u7ec6\u80de\u529f\u80fd\u969c\u788d\u3002\u56e0\u6b64\uff0c\u63a2\u7d22\u6839\u6cbb\u7cd6\u5c3f\u75c5\u7684\u6709\u6548\u65b9\u6cd5\u81f3\u5173\u91cd\u8981\u3002<\/span><\/p>\n<div id=\"attachment_20210\" style=\"width: 622px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-20210\" class=\"wp-image-20210 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/istockphoto-2230780533-612x612-1.jpg\" alt=\"\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6cbb\u7597\u7cd6\u5c3f\u75c5\uff1a\u662f\u7406\u60f3\u5019\u9009\u7597\u6cd5\u5417\uff1f\" width=\"612\" height=\"344\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/istockphoto-2230780533-612x612-1.jpg 612w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/istockphoto-2230780533-612x612-1-300x169.jpg 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/istockphoto-2230780533-612x612-1-18x10.jpg 18w\" sizes=\"(max-width: 612px) 100vw, 612px\" \/><p id=\"caption-attachment-20210\" class=\"wp-caption-text\">\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6cbb\u7597\u7cd6\u5c3f\u75c5\uff1a\u662f\u7406\u60f3\u5019\u9009\u7597\u6cd5\u5417\uff1f<\/p><\/div>\n<p><span dir=\"auto\">\u5bfb\u627e\u53ef\u7528\u4e8e\u66ff\u4ee3\u53d7\u635f\u6216\u4e22\u5931\u7684\u03b2<\/span><span dir=\"auto\">\u7ec6\u80de\u7684\u79cd\u5b50\u7ec6\u80de\uff0c\u6216\u8bb8\u662f\u6cbb\u6108\u7cd6\u5c3f\u75c5\u7684\u4e00\u79cd\u5f88\u6709\u524d\u666f\u7684\u65b9\u6cd5\u3002\u65e2\u5f80\u62a5\u9053\u663e\u793a\uff0c\u80f0\u5c9b\u7ec6\u80de\u5df2\u88ab\u79fb\u690d\u5230\u60a3\u8005\u4f53\u5185\uff0c\u4ee5\u66ff\u4ee3\u529f\u80fd\u4e27\u5931\u7684\u80f0\u5c9b\u7ec6\u80de\uff0c\u5e76\u6210\u529f\u6539\u5584\u4e86\u80f0\u5c9b\u7d20\u9700\u6c42<\/span><span dir=\"auto\">\u3002\u7136\u800c\uff0c\u7531\u4e8e\u4f9b\u4f53\u77ed\u7f3a\u3001\u514d\u75ab\u6392\u65a5\u4ee5\u53ca\u4e25\u91cd\u7684\u672f\u540e\u5e76\u53d1\u75c7\uff0c\u5176\u5e94\u7528\u53d7\u5230\u9650\u5236<\/span><span dir=\"auto\">\u3002\u5e78\u8fd0\u7684\u662f\uff0c<a href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/mscs\/20023.html\/\" target=\"_blank\" rel=\"noopener\">\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09<\/a>\u56e0\u5176\u4f4e\u514d\u75ab\u539f\u6027\u548c\u81ea\u6211\u66f4\u65b0\u80fd\u529b\u800c\u5907\u53d7\u5173\u6ce8\uff0c\u5b83\u4eec\u53ef\u4ee5\u88ab\u8bf1\u5bfc\u5206\u5316\u4e3a\u80f0\u5c9b\u7d20\u5206\u6ccc\u7ec6\u80de\uff08IPCs\uff09\uff0c\u5e76\u5728\u7cd6\u5c3f\u75c5\u6cbb\u7597\u9886\u57df\u5f15\u8d77\u4e86\u5e7f\u6cdb\u5173\u6ce8\u3002\u66f4\u91cd\u8981\u7684\u662f\uff0cMSCs\u8fd8\u5177\u6709\u514d\u75ab\u8c03\u8282\u548c\u6297\u708e\u7279\u6027\uff0c\u5df2\u88ab\u5e7f\u6cdb\u7528\u4e8e\u6cbb\u7597\u91cd\u578b\u518d\u751f\u969c\u788d\u6027\u8d2b\u8840<\/span><span dir=\"auto\">\u3001\u591a\u53d1\u6027\u786c\u5316\u75c7\u548c<\/span><span dir=\"auto\">\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e<\/span><span dir=\"auto\">\u7b49\u514d\u75ab\u6027\u75be\u75c5\u3002\u6b64\u5916\uff0c\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u53ef\u4ee5\u5206\u6ccc\u4e00\u4e9b\u7ec6\u80de\u56e0\u5b50\uff0c\u8fd9\u6709\u5229\u4e8e\u6539\u5584\u80f0\u817a\u7684\u5fae\u73af\u5883\uff0c\u4ece\u800c\u4fdd\u62a4\u80f0\u5c9b\u529f\u80fd\uff0c\u751a\u81f3\u9006\u8f6c\u53d7\u635f\u7684\u7ec6\u80de\u529f\u80fd\u3002<\/span><\/p>\n<h2 id=\"sec-0002-title\" class=\"article-section__title section__title section1\"><span class=\"ez-toc-section\" id=\"%E4%B8%80%E3%80%81IPCs%E7%A7%BB%E6%A4%8D\"><\/span><span dir=\"auto\">\u4e00\u3001IPCs\u79fb\u690d<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p class=\"ds-markdown-paragraph\"><strong>01\u3001\u6838\u5fc3\u673a\u5236\uff08\u4e3a\u4ec0\u4e48IPCs\u79fb\u690d\u91cd\u8981\uff09<\/strong><\/p>\n<p class=\"ds-markdown-paragraph\">IPCs\uff08\u80f0\u5c9b\u6837\u7ec6\u80de\uff09\u79fb\u690d\u662f\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6cbb\u7597\u7cd6\u5c3f\u75c5\u7684\u5173\u952e\u7b56\u7565\u4e4b\u4e00\u3002\u5176\u6838\u5fc3\u5728\u4e8e\uff0c\u901a\u8fc7\u4f53\u5916\u8bf1\u5bfc\u5c06MSCs\u9ad8\u6548\u5206\u5316\u4e3a\u5177\u6709\u529f\u80fd\u7684IPCs\uff0c\u518d\u79fb\u690d\u81f3\u4f53\u5185\u4ee5\u8c03\u8282\u8840\u7cd6\u3002<span dir=\"auto\">\u88681<\/span><span dir=\"auto\">\u5217\u51fa\u4e86\u5df2\u53d1\u8868\u7684\u5173\u4e8eMSCs\u5206\u5316\u4e3aIPCs\u7684\u6587\u732e\uff0c\u8fd9\u4e9bIPCs\u5df2\u88ab\u8bc1\u5b9e\u53ef\u5728\u4f53\u5916\u548c\u4f53\u5185\u5bf9\u8461\u8404\u7cd6\u523a\u6fc0\u4ea7\u751f\u826f\u597d\u53cd\u5e94\u3002<\/span><\/p>\n<table class=\"table article-section__table\">\n<thead>\n<tr>\n<th class=\"right-bordered-cell left-aligned\"><span dir=\"auto\">Cell Source<\/span><\/th>\n<th class=\"center-aligned\"><span dir=\"auto\">\u8bf1\u5bfc\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u5206\u5316\u4e3a\u7f3a\u8840\u9884\u9002\u5e94\u5e72\u7ec6\u80de<\/span><\/th>\n<th class=\"center-aligned\"><span dir=\"auto\">\u79fb\u690d\u65b9\u6cd5\u53ca\u7ed3\u679c<\/span><\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td class=\"right-bordered-cell left-aligned\" rowspan=\"2\"><i><span dir=\"auto\">\u5927\u9f20\u9aa8\u9ad3\u95f4\u5145\u8d28\u5e72\u7ec6\u80de<\/span><\/i><span dir=\"auto\">[\u00a0<\/span><a id=\"bib-0026_R_d193811385e461\" class=\"bibLink tab-link\" href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2021\/9938658#bib-0026\" data-tab=\"pane-pcw-references\" aria-label=\"\u53c2\u8003\u6587\u732e26 - \u7ec6\u80de\u79fb\u690d\" rel=\"nofollow noopener\" target=\"_blank\"><span dir=\"auto\">26<\/span><\/a><span dir=\"auto\">\u00a0]<\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\">\u7b2c 1 \u9636\u6bb5\uff0c\u7b2c 6 \u5929\uff1a10 ng\/ml bFGF\u300110 ng\/ml EGF\u30012% B27<\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\">\u79fb\u690d\u65b9\u5f0f\uff1a\u8179\u8154\u5185\u6ce8\u5c04<\/span><\/td>\n<\/tr>\n<tr>\n<td class=\"center-aligned\"><span dir=\"auto\">\u7b2c 2 \u9636\u6bb5\uff0c6 \u5929\uff1a10 ng\/ml HGF\u300110 ng\/ml b-cellulin\u300110 ng\/ml AA\u300110 mmol\/L NA\u30012% B27<\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\">\u7ed3\u679c\uff1aIPC\u79fb\u690d\u6539\u5584\u80f0\u5c9b\u7d20\u6c34\u5e73\u7684\u6548\u679c\u4f18\u4e8eMSC\u79fb\u690d\u3002<\/span><\/td>\n<\/tr>\n<tr>\n<td class=\"bottom-bordered-cell left-aligned\" colspan=\"3\"><\/td>\n<\/tr>\n<tr>\n<td class=\"right-bordered-cell left-aligned\"><i><span dir=\"auto\">\u4eba\u7c7b\u9aa8\u9ad3\u95f4\u5145\u8d28\u5e72\u7ec6\u80de<\/span><\/i><span dir=\"auto\">[\u00a0<\/span><a id=\"bib-0024_R_d193811385e492\" class=\"bibLink tab-link\" href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2021\/9938658#bib-0024\" data-tab=\"pane-pcw-references\" aria-label=\"\u53c2\u8003\u6587\u732e 24 - \u5e72\u7ec6\u80de\uff08\u4fc4\u4ea5\u4fc4\u5dde\u4ee3\u987f\u5e02\uff09\" rel=\"nofollow noopener\" target=\"_blank\"><span dir=\"auto\">24<\/span><\/a><span dir=\"auto\">\u00a0]\uff1b<\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\">\u7b2c\u4e00\u9636\u6bb5\uff0c3\u5929\uff1a55 nmol\/L TSA\uff0c\u65e0\u8840\u6e05DMEM\u57f9\u517b\u57fa<\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\">\u79fb\u690d\u65b9\u6cd5\uff1a\u5c06\u7ec6\u80de\u88c5\u8f7d\u4e8e2\u4e2aTheraCyte\u80f6\u56ca\u4e2d\uff0c\u7136\u540e\u79fb\u690d\u5230\u8179\u76f4\u808c\u9798\u4e0b\u3002<\/span><\/td>\n<\/tr>\n<tr>\n<td class=\"bottom-bordered-cell left-aligned\" colspan=\"3\"><\/td>\n<\/tr>\n<tr>\n<td class=\"right-bordered-cell left-aligned\"><i><span dir=\"auto\">\u5c0f\u9f20\u9aa8\u9ad3\u95f4\u5145\u8d28\u5e72\u7ec6\u80de<\/span><\/i><span dir=\"auto\">[\u00a0<\/span><a id=\"bib-0028_R_d193811385e515\" class=\"bibLink tab-link\" href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2021\/9938658#bib-0028\" data-tab=\"pane-pcw-references\" aria-label=\"\u53c2\u8003\u6587\u732e28 - \u751f\u7269\u533b\u5b66\u7814\u7a76\u56fd\u9645\" rel=\"nofollow noopener\" target=\"_blank\"><span dir=\"auto\">28<\/span><\/a><span dir=\"auto\">\u00a0]<\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\">\u7b2c\u4e8c\u9636\u6bb5\uff0c7\u5929\uff1a10 nmol\/L GLP-1\uff0c10% FBS\uff0cDMEM\uff1aDMEM\/F12<\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\">\u7ed3\u679c\uff1a\u79fb\u690d\u7684\u7ec6\u80de\u5bf9\u8461\u8404\u7cd6\u6709\u53cd\u5e94\u5e76\u80fd\u5206\u6ccc\u80f0\u5c9b\u7d20\u3002\u79fb\u690d\u540e4\u5468\uff0c\u8840\u7cd6\u503c\u6062\u590d\u6b63\u5e38\u3002<\/span><\/td>\n<\/tr>\n<tr>\n<td class=\"bottom-bordered-cell left-aligned\" colspan=\"3\"><\/td>\n<\/tr>\n<tr>\n<td class=\"right-bordered-cell left-aligned\" rowspan=\"2\"><i><span dir=\"auto\">\u5927\u9f20\u8102\u80aa\u95f4\u5145\u8d28\u5e72\u7ec6\u80de<\/span><\/i><span dir=\"auto\">[\u00a0<\/span><a id=\"bib-0029_R_d193811385e537\" class=\"bibLink tab-link\" href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2021\/9938658#bib-0029\" data-tab=\"pane-pcw-references\" aria-label=\"\u53c2\u8003\u6587\u732e 29 - \u751f\u7269\u533b\u5b66\u6750\u6599\u4e0e\u5de5\u7a0b\" rel=\"nofollow noopener\" target=\"_blank\"><span dir=\"auto\">29<\/span><\/a><span dir=\"auto\">\u00a0]<\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\">\u7b2c\u4e00\u9636\u6bb5\uff0c2\u5929\uff1a10 mmol\/l NA\uff0c0.5 mmol\/l\u00a0<\/span><i><span dir=\"auto\">\u03b2-<\/span><\/i><span dir=\"auto\">\u5def\u57fa\u4e59\u9187\u548c\u65e0\u8840\u6e05\u9ad8\u7cd6DMEM\uff0825 mmol\/l\uff09<\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\">\u79fb\u690d\u65b9\u5f0f\uff1a\u79fb\u690d\u5230\u813e\u810f\u8fdc\u7aef<\/span><\/td>\n<\/tr>\n<tr>\n<td class=\"center-aligned\"><span dir=\"auto\">\u7b2c\u4e8c\u9636\u6bb5\uff0c26 \u5929\uff1a30 ng\/ml FGF\uff0c10 mmol\/l NA \u548c\u65e0\u8840\u6e05\u9ad8\u7cd6 DMEM (25 mmol\/l)<\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\">\u7ed3\u679c\uff1aIPC\u79fb\u690d\u663e\u8457\u964d\u4f4e\u4e86\u8840\u7cd6\u6c34\u5e73\u3002\u800c\u4e14\uff0cIPC\u5728\u4f53\u5185\u786e\u5b9e\u5bf9\u8461\u8404\u7cd6\u8d1f\u8377\u6709\u53cd\u5e94\u3002<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong>02\u3001\u8bf1\u5bfc\u65b9\u5f0f\u4e0e\u7814\u7a76\u8fdb\u5c55\uff08\u7814\u7a76\u600e\u4e48\u505a\u7684\uff09<\/strong><\/p>\n<p class=\"ds-markdown-paragraph\">\u76ee\u524d\u4e3b\u6d41\u7684\u8bf1\u5bfc\u65b9\u6cd5\u5206\u4e3a\u57fa\u56e0\u5de5\u7a0b\u4e0e\u5316\u5b66\u8bf1\u5bfc\u4e24\u7c7b\u3002\u57fa\u56e0\u5de5\u7a0b\u6cd5\u6548\u7387\u8f83\u9ad8\uff0c\u4f46\u56e0\u5176\u6210\u672c\u9ad8\u6602\u3001\u64cd\u4f5c\u590d\u6742\u4e14\u75c5\u6bd2\u8f7d\u4f53\u6f5c\u5728\u98ce\u9669\u800c\u53d7\u9650\u3002\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u5316\u5b66\u8bf1\u5bfc\u6cd5\u4f7f\u7528Activin A\u3001\u70df\u9170\u80fa\u7b49\u65e0\u514d\u75ab\u539f\u6027\u3001\u6613\u4e8e\u6807\u51c6\u5316\u7684\u5c0f\u5206\u5b50\u5316\u5408\u7269\uff0c\u901a\u8fc7\u6a21\u62df\u80f0\u817a\u53d1\u80b2\u73af\u5883\uff0c\u5206\u9636\u6bb5\u5c06MSCs\u8bf1\u5bfc\u4e3aIPCs\uff0c\u5728\u5b9e\u8df5\u4e2d\u5e94\u7528\u66f4\u5e7f\u3002<\/p>\n<p class=\"ds-markdown-paragraph\">\u7814\u7a76\u8bc1\u660e\uff0c\u7ecf\u5316\u5b66\u8bf1\u5bfc\u83b7\u5f97\u7684IPCs\u5728\u4f53\u5185\u5916\u5747\u80fd\u5bf9\u8461\u8404\u7cd6\u523a\u6fc0\u4ea7\u751f\u826f\u597d\u53cd\u5e94\u3002\u4f8b\u5982\uff0cKarimi\u7b49\u5229\u7528\u7ef4\u683c\u5217\u6c40\u7b49\u5316\u5408\u7269\u7ec4\u5408\uff0c\u4f7f\u8102\u80aa\u6765\u6e90MSCs\u7684\u80f0\u5c9b\u7d20\u91ca\u653e\u91cf\u63d0\u5347\u81f3\u5bf9\u7167\u7ec4\u76843.6\u500d\uff1bMahmoud\u7b49\u7684\u7814\u7a76\u8fdb\u4e00\u6b65\u8868\u660e\uff0c\u5c06\u6b64\u7c7bIPCs\u79fb\u690d\u5165\u7cd6\u5c3f\u75c5\u52a8\u7269\u6a21\u578b\uff0c\u53ef\u957f\u671f\u7ef4\u6301\u6b63\u5e38\u8840\u7cd6\uff0c\u5176\u6548\u679c\u751a\u81f3\u4f18\u4e8e\u76f4\u63a5\u79fb\u690dMSCs\u3002<\/p>\n<p><strong>03\u3001\u5b58\u5728\u7684\u6311\u6218\uff08\u95ee\u9898\u4e0e\u4e0d\u8db3\uff09<\/strong><\/p>\n<p class=\"ds-markdown-paragraph\">\u5c3d\u7ba1\u524d\u666f\u5e7f\u9614\uff0c\u8be5\u6280\u672f\u4ecd\u9762\u4e34\u6311\u6218\uff1a\u5316\u5b66\u8bf1\u5bfc\u53ef\u80fd\u7f29\u77ed\u7ec6\u80de\u5b58\u6d3b\u65f6\u95f4\uff1b\u5176\u4f53\u5185\u8f6c\u5206\u5316\u7684\u6709\u6548\u6027\u4ecd\u9700\u66f4\u786e\u51ff\u8bc1\u636e\uff1b\u6b64\u5916\uff0cIPCs\u4ecd\u53ef\u80fd\u5f15\u53d1\u4e00\u5b9a\u7a0b\u5ea6\u7684\u514d\u75ab\u6216\u708e\u75c7\u53cd\u5e94\u3002\u8fd9\u4e9b\u662f\u672a\u6765\u7814\u7a76\u9700\u8981\u7a81\u7834\u7684\u5173\u952e\u70b9\u3002<\/p>\n<h2 id=\"sec-0003-title\" class=\"article-section__title section__title section1\"><span class=\"ez-toc-section\" id=\"2%E3%80%81%E4%B8%B4%E5%BA%8A%E9%97%B4%E5%85%85%E8%B4%A8%E5%B9%B2%E7%BB%86%E8%83%9E%E7%A7%BB%E6%A4%8D%E6%B2%BB%E7%96%97%E7%B3%96%E5%B0%BF%E7%97%85\"><\/span><span dir=\"auto\">2\u3001\u4e34\u5e8a\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u79fb\u690d\u6cbb\u7597\u7cd6\u5c3f\u75c5<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<section id=\"sec-0004\" class=\"article-section__sub-content\">\n<h3 id=\"sec-0004-title\" class=\"article-section__sub-title section2\"><span class=\"ez-toc-section\" id=\"21_MSCs%E6%B2%BB%E7%96%971%E5%9E%8B%E7%B3%96%E5%B0%BF%E7%97%85%E7%9A%84%E4%B8%B4%E5%BA%8A%E7%A0%94%E7%A9%B6\"><\/span><span dir=\"auto\">2.1. MSCs\u6cbb\u75971\u578b\u7cd6\u5c3f\u75c5\u7684\u4e34\u5e8a\u7814\u7a76<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<\/section>\n<p class=\"ds-markdown-paragraph\"><strong>\u75c5\u56e0\u4e0e\u6cbb\u7597\u73b0\u72b6\uff1a<\/strong>1\u578b\u7cd6\u5c3f\u75c5\uff08T1DM\uff09\u672c\u8d28\u4e0a\u662f\u4e00\u79cd\u81ea\u8eab\u514d\u75ab\u75be\u75c5\uff0c\u5176\u6838\u5fc3\u75c5\u7406\u662fT\u7ec6\u80de\u4ecb\u5bfc\u7684\u80f0\u5c9b\u03b2\u7ec6\u80de\u88ab\u7279\u5f02\u6027\u7834\u574f\u3002\u8fd9\u4e2a\u7834\u574f\u8fc7\u7a0b\u72b9\u5982\u4e00\u4e2a\u201c\u6c89\u9ed8\u6740\u624b\u201d\uff0c\u5728\u75c5\u7a0b\u65e9\u671f\u96be\u4ee5\u5bdf\u89c9\uff0c\u53ea\u6709\u5f53\u4f53\u5185\u9ad8\u8fbe80%\u4ee5\u4e0a\u7684\u03b2\u7ec6\u80de\u88ab\u635f\u6bc1\u540e\uff0c\u80f0\u5c9b\u7d20\u5206\u6ccc\u80fd\u529b\u4e25\u91cd\u8870\u7aed\uff0c\u75be\u75c5\u624d\u4f1a\u4e34\u5e8a\u53d1\u4f5c\u3002\u56e0\u6b64\uff0c\u60a3\u8005\u5fc5\u987b\u4f9d\u8d56\u6bcf\u65e5\u5916\u6e90\u6027\u80f0\u5c9b\u7d20\u6ce8\u5c04\u6765\u7ef4\u6301\u751f\u547d\uff0c\u56e0\u4e3a\u80f0\u5c9b\u7d20\u662f\u8c03\u8282\u8461\u8404\u7cd6\u6444\u53d6\u4e0e\u4ee3\u8c22\u3001\u638c\u63a7\u7ec6\u80de\u80fd\u91cf\u50a8\u5b58\u4e0e\u5229\u7528\u7684\u5173\u952e\u6fc0\u7d20\u3002<\/p>\n<p class=\"ds-markdown-paragraph\"><strong>\u5f53\u524d\u7597\u6cd5\u7684\u5c40\u9650\u4e0e\u98ce\u9669\uff1a<\/strong>\u7136\u800c\uff0c\u8fd9\u79cd\u8d56\u4ee5\u751f\u5b58\u7684\u76ae\u4e0b\u6ce8\u5c04\u7597\u6cd5\u5e76\u4e0d\u7b26\u5408\u751f\u7406\u72b6\u6001\uff0c\u5176\u8c03\u63a7\u65b9\u5f0f\u7c97\u7cd9\u3002\u5916\u6e90\u6027\u80f0\u5c9b\u7d20\u65e0\u6cd5\u50cf\u5065\u5eb7\u80f0\u5c9b\u03b2\u7ec6\u80de\u90a3\u6837\uff0c\u5bf9\u8840\u7cd6\u6ce2\u52a8\u505a\u51fa\u77ac\u65f6\u3001\u7cbe\u51c6\u7684\u53cd\u5e94\uff0c\u5373\u65e0\u6cd5\u5b9e\u73b0\u201c\u8461\u8404\u7cd6\u523a\u6fc0\u7684\u80f0\u5c9b\u7d20\u5206\u6ccc\uff08GSIS\uff09\u201d\u8fd9\u4e00\u7cbe\u5bc6\u751f\u7406\u8fc7\u7a0b\u3002\u8fd9\u79cd\u8c03\u8282\u5931\u8861\u5bfc\u81f4\u4e24\u5927\u540e\u679c\uff1a\u4e00\u662f\u65e0\u6cd5\u6709\u6548\u5e73\u590d\u9910\u540e\u8840\u7cd6\u9ad8\u5cf0\uff0c\u957f\u671f\u4ee5\u5f80\u4f1a\u9a71\u52a8\u5fae\u8840\u7ba1\u4e0e\u5927\u8840\u7ba1\u7b49\u6162\u6027\u5e76\u53d1\u75c7\u7684\u53d1\u751f\uff1b\u4e8c\u662f\u7531\u4e8e\u836f\u4ee3\u52a8\u529b\u5b66\u5ef6\u8fdf\uff0c\u836f\u7269\u4f5c\u7528\u4e0e\u8eab\u4f53\u9700\u6c42\u4e0d\u5339\u914d\uff0c\u81f4\u4f7f\u5371\u9669\u7684\u6025\u6027\u5e76\u53d1\u75c7\u2014\u2014\u4f4e\u8840\u7cd6\u4ecd\u9891\u7e41\u53d1\u751f\u3002<\/p>\n<p><span dir=\"auto\">\u4e3a\u4e86\u6539\u5584\u8fd9\u4e00\u56f0\u5883\uff0c\u8bb8\u591a\u79d1\u5b66\u5bb6\u6b63\u81f4\u529b\u4e8e\u5229\u7528\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSC\uff09\u6cbb\u7597\u7cd6\u5c3f\u75c5\u3002\u4e00\u4e9b\u4e34\u5e8a\u9879\u76ee\u5df2\u83b7\u6279\u51c6\u3002\u622a\u81f32025\u5e7410\u6708\uff0c\u4e34\u5e8a\u8bd5\u9a8c\u6ce8\u518c\u4e2d\u5fc3\uff08<\/span><a class=\"linkBehavior\" href=\"http:\/\/www.clinicaltrials.gov\/\" rel=\"nofollow noopener\" target=\"_blank\"><span dir=\"auto\">http:\/\/www.clinicaltrials.gov<\/span><\/a><span dir=\"auto\">\uff09\u6536\u5f55\u4e8627\u9879\u5173\u4e8eMSC\u6cbb\u75971\u578b\u7cd6\u5c3f\u75c5\uff08T1DM\uff09\u7684\u4e34\u5e8a\u7814\u7a76\uff0c\u5176\u4e2d\u5927\u90e8\u5206\u7814\u7a76\u4f7f\u7528\u8110\u5e26\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08UC-MSC\uff09\uff0c\u5305\u62ec\u534e\u901a\u6c0f\u80f6\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08WJ-MSC\uff09\u548c\u9aa8\u9ad3\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08BM-MSC\uff09\u6cbb\u7597\u7cd6\u5c3f\u75c5\uff0c\u53e6\u6709\u4e00\u9879\u7814\u7a76\u4f7f\u7528\u6708\u7ecf\u8840\u6765\u6e90\u7684MSC\uff0c\u8fd8\u6709\u4e00\u9879\u7814\u7a76\u4f7f\u7528\u8131\u843d\u7259\u9f7f\u6765\u6e90\u7684MSC\u6cbb\u7597T1DM\u3002\u672c\u7efc\u8ff0\u5e76\u975e\u4ee5\u7cd6\u5c3f\u75c5\u5e76\u53d1\u75c7\u7684\u6cbb\u7597\u4e3a\u4e3b\u8981\u5185\u5bb9\u3002\u88682<\/span><span dir=\"auto\">\u5217\u51fa\u4e86\u9664\u7cd6\u5c3f\u75c5\u5e76\u53d1\u75c7\u6cbb\u7597\u5916\uff0c\u7528\u4e8e\u8bc4\u4f30\u79fb\u690dMSC\u6cbb\u7597T1DM\u7684\u5df2\u53d1\u8868\u6587\u732e\u3002<\/span><\/p>\n<p><span dir=\"auto\">Carlsson \u7684\u7814\u7a76 [ <\/span><a id=\"bib-0039_R_d193811385e824\" class=\"bibLink tab-link\" href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2021\/9938658#bib-0039\" data-tab=\"pane-pcw-references\" aria-label=\"\u53c2\u8003\u6587\u732e39 - \u7cd6\u5c3f\u75c5\" rel=\"nofollow noopener\" target=\"_blank\"><span dir=\"auto\">39<\/span><\/a><span dir=\"auto\">\u00a0] \u662f\u4e00\u9879\u5f00\u653e\u6807\u7b7e\u7684\u5355\u4e2d\u5fc3\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\uff0c\u65e8\u5728\u9996\u6b21\u8bc4\u4f30\u81ea\u4f53\u9aa8\u9ad3\u95f4\u5145\u8d28\u5e72\u7ec6\u80de (BM-MSCs) \u6cbb\u7597\u65b0\u8bca\u65ad\u7684 1 \u578b\u7cd6\u5c3f\u75c5 (T1DM) \u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002\u6240\u6709\u5728\u968f\u8bbf\u671f\u95f4\u63a5\u53d7\u81ea\u4f53 BM-MSCs \u6cbb\u7597\u7684\u60a3\u8005\u5747\u8010\u53d7\u826f\u597d\uff0c\u672a\u53d1\u751f\u4e0d\u826f\u4e8b\u4ef6\u3002\u6b64\u5916\uff0c\u5927\u591a\u6570\u968f\u673a\u5206\u914d\u81f3 MSC \u6cbb\u7597\u7ec4\u7684\u60a3\u8005\u5728\u7814\u7a76\u671f\u95f4\u6df7\u5408\u9910\u8010\u91cf\u8bd5\u9a8c (MMTT) \u4e2d C \u80bd\u53cd\u5e94\u80fd\u529b\u6709\u6240\u63d0\u9ad8\uff0c\u4e0e\u5bf9\u7167\u7ec4\u76f8\u6bd4\uff0c\u5cf0\u503c C \u80bd\u53cd\u5e94\u548c MMTT C \u80bd\u53cd\u5e94\u7684 \u0394 \u503c\u5747\u6709\u6240\u589e\u52a0 [\u00a0<\/span><a id=\"bib-0039_R_d193811385e827\" class=\"bibLink tab-link\" href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2021\/9938658#bib-0039\" data-tab=\"pane-pcw-references\" aria-label=\"\u53c2\u8003\u6587\u732e39 - \u7cd6\u5c3f\u75c5\" rel=\"nofollow noopener\" target=\"_blank\"><span dir=\"auto\">39<\/span><\/a><span dir=\"auto\">\u00a0]\u3002<\/span><\/p>\n<p><span dir=\"auto\">\u7136\u800c\uff0c\u5728\u672c\u7814\u7a76\u4e2d\uff0cMSCs \u6cbb\u7597\u524d C \u80bd\u5cf0\u503c\u3001C \u80bd\u3001\u7cd6\u5316\u8840\u7ea2\u86cb\u767d (HbA1c) \u548c\u80f0\u5c9b\u7d20\u9700\u6c42\u91cf\u5747\u65e0\u663e\u8457\u6539\u5584\uff0c\u4ec5\u4e0e\u5bf9\u7167\u7ec4\u76f8\u6bd4\u6709\u663e\u8457\u6539\u5584\u3002Hu \u7b49 [\u00a0<\/span><a id=\"bib-0040_R_d193811385e830\" class=\"bibLink tab-link\" href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2021\/9938658#bib-0040\" data-tab=\"pane-pcw-references\" aria-label=\"\u53c2\u8003\u6587\u732e 40 - \u5185\u5206\u6ccc\u5b66\u6742\u5fd7\" rel=\"nofollow noopener\" target=\"_blank\"><span dir=\"auto\">40<\/span><\/a><span dir=\"auto\"> ] \u548c Cai \u7b49 [41] \u7684\u7814\u7a76\u4e5f\u652f\u6301\u4e86\u8fd9\u4e00\u89c2\u70b9\u3002<\/span><\/p>\n<p><span dir=\"auto\">[\u00a0<\/span><a id=\"bib-0041_R_d193811385e834\" class=\"bibLink tab-link\" href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2021\/9938658#bib-0041\" data-tab=\"pane-pcw-references\" aria-label=\"\u53c2\u8003\u6587\u732e 41 - \u7cd6\u5c3f\u75c5\u62a4\u7406\" rel=\"nofollow noopener\" target=\"_blank\"><span dir=\"auto\">41<\/span><\/a><span dir=\"auto\">\u00a0]\u62a5\u9053\u79f0\uff0c\u8110\u5e26\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08UC-MSCs\uff09\u6cbb\u7597\u540e\u60a3\u8005\u7684\u4ee3\u8c22\u6307\u6807\u663e\u8457\u6539\u5584\uff0c\u8fd9\u4e00\u7ed3\u679c\u4ee4\u4eba\u9f13\u821e\uff0c\u524d\u666f\u53ef\u671f\u3002\u8fd9\u4e9b\u7814\u7a76\u5747\u672a\u53d1\u73b0\u660e\u663e\u7684\u526f\u4f5c\u7528\uff0c\u8bc1\u660e\u4e86\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u7597\u6cd5\u7684\u5b89\u5168\u6027\u3002<\/span><\/p>\n<table class=\"table article-section__table\">\n<thead>\n<tr>\n<th class=\"right-bordered-cell left-aligned\"><span dir=\"auto\">\u53d1\u5e03<\/span><\/th>\n<th class=\"center-aligned\"><span dir=\"auto\">\u7ec6\u80de\u8d44\u6e90<\/span><\/th>\n<th class=\"center-aligned\"><span dir=\"auto\">\u6ce8\u5c04\u6cd5<\/span><\/th>\n<th class=\"center-aligned\"><span dir=\"auto\">\u6ce8\u5c04\u5242\u91cf<\/span><\/th>\n<th class=\"center-aligned\"><span dir=\"auto\">\u540e\u7eed\u65f6\u95f4<\/span><\/th>\n<th class=\"center-aligned\"><span dir=\"auto\">\u7597\u6548\u8bc4\u4ef7\u6307\u6570<\/span><\/th>\n<th class=\"center-aligned\"><span dir=\"auto\">\u7ed3\u679c<\/span><\/th>\n<th class=\"center-aligned\"><span dir=\"auto\">\u4e0d\u826f\u4e8b\u4ef6<\/span><\/th>\n<th class=\"center-aligned\"><span dir=\"auto\">\u7814\u7a76\u8bbe\u8ba1<\/span><\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td class=\"right-bordered-cell left-aligned\"><span dir=\"auto\">Carlsson \u7b49\u4eba[\u00a0<\/span><a id=\"bib-0039_R_d193811385e914\" class=\"bibLink tab-link\" href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2021\/9938658#bib-0039\" data-tab=\"pane-pcw-references\" aria-label=\"\u53c2\u8003\u6587\u732e39 - \u7cd6\u5c3f\u75c5\" rel=\"nofollow noopener\" target=\"_blank\"><span dir=\"auto\">39<\/span><\/a><span dir=\"auto\">\u00a0]<\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\">\u81ea\u4f53\u9aa8\u9ad3\u95f4\u5145\u8d28\u5e72\u7ec6\u80de<\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\">\u9759\u8109\u6ef4\u6ce8<\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\">2.75 \u00d7 10^6 \u4e2a\u7ec6\u80de\/\u5343\u514b<\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\">12\u4e2a\u6708<\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\">MMTT\u3001AUC\u3001HbA1c\u3001C\u80bd\u3001\u80f0\u5c9b\u7d20\u9700\u6c42<\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\">\u5728\u6df7\u5408\u9910\u8010\u91cf\u8bd5\u9a8c\uff08MMTT\uff09\u4e2d\uff0c\u5bf9\u7167\u7ec4\u60a3\u8005\u5728\u7b2c\u4e00\u5e74C\u80bd\u5cf0\u503c\u548cC\u80bd\u66f2\u7ebf\u4e0b\u9762\u79ef\uff08AUC\uff09\u5747\u51fa\u73b0\u5e73\u5747\u4e0b\u964d\u3002\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u63a5\u53d7\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSC\uff09\u6cbb\u7597\u7684\u60a3\u8005\u5219\u4fdd\u6301\u4e86\u8fd9\u4e9b\u53cd\u5e94\u3002<\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\">\u65e0\u526f\u4f5c\u7528<\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\">\u5f00\u653e\u5f0f\u3001\u5355\u4e2d\u5fc3\u3001\u968f\u673a\u8bd5\u70b9\u7814\u7a76<\/span><\/td>\n<\/tr>\n<tr>\n<td class=\"bottom-bordered-cell left-aligned\" colspan=\"9\"><\/td>\n<\/tr>\n<tr>\n<td class=\"right-bordered-cell left-aligned\"><span dir=\"auto\">\u80e1\u7b49\u4eba[\u00a0<\/span><a id=\"bib-0040_R_d193811385e954\" class=\"bibLink tab-link\" href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2021\/9938658#bib-0040\" data-tab=\"pane-pcw-references\" aria-label=\"\u53c2\u8003\u6587\u732e40 - \u5185\u5206\u6ccc\u5b66\u6742\u5fd7\" rel=\"nofollow noopener\" target=\"_blank\"><span dir=\"auto\">40<\/span><\/a><span dir=\"auto\">\u00a0]<\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">WJ-MSC<\/span><\/span><\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\">intravenous infusion<\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\">1.5\u20133.2 \u00d7 10^7 \u4e2a\u7ec6\u80de\/\u5343\u514b<\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\">24\u4e2a\u6708<\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\">\u7a7a\u8179\u8840\u7cd6 (FBG)\u3001\u9910\u540e\u8840\u7cd6 (PBG)\u3001\u7cd6\u5316\u8840\u7ea2\u86cb\u767d (HbA1c)\u3001\u76ae\u8d28\u9187\u78f7\u9178\u916f (CPGR)\u3001C\u80bd\u3001\u8c37\u6c28\u9178\u8131\u7fa7\u9176\u6297\u4f53 (GADA)\u3001\u80f0\u5c9b\u7d20\u9700\u6c42\u91cf<\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\">\u5728\u968f\u8bbf\u671f\u95f4\uff0cHbA1c \u548c C \u80bd\u5747\u660e\u663e\u4f18\u4e8e\u6cbb\u7597\u524d\u503c\u6216\u5bf9\u7167\u7ec4\u60a3\u8005\u3002<\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\">\u65e0\u660e\u663e\u4e0d\u826f\u53cd\u5e94<\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\">\u968f\u673a\u53cc\u76f2\u7814\u7a76<\/span><\/td>\n<\/tr>\n<tr>\n<td class=\"bottom-bordered-cell left-aligned\" colspan=\"9\"><\/td>\n<\/tr>\n<tr>\n<td class=\"right-bordered-cell left-aligned\"><span dir=\"auto\">Cai \u7b49\u4eba[\u00a0<\/span><a id=\"bib-0041_R_d193811385e994\" class=\"bibLink tab-link\" href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2021\/9938658#bib-0041\" data-tab=\"pane-pcw-references\" aria-label=\"\u53c2\u8003\u6587\u732e41 - \u7cd6\u5c3f\u75c5\u62a4\u7406\" rel=\"nofollow noopener\" target=\"_blank\"><span dir=\"auto\">41<\/span><\/a><span dir=\"auto\">\u00a0]<\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\">\u8110\u5e26\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u548c\u81ea\u4f53\u9aa8\u9ad3\u5355\u6838\u7ec6\u80de<\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\">\u901a\u8fc7\u80f0\u52a8\u8109\u8f93\u6ce8<\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\">1.1 \u00d7 10^6 \u4e2a\u7ec6\u80de\/\u5343\u514b<\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">12\u4e2a\u6708<\/span><\/span><\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\">AUCC-pep\u3001HbA1c\u3001FBG\u3001C\u80bd\u3001\u80f0\u5c9b\u7d20\u9700\u6c42<\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\">\u6cbb\u7597\u8010\u53d7\u6027\u826f\u597d\u3002\u4e00\u5e74\u540e\uff0c\u63a5\u53d7\u6cbb\u7597\u7684\u60a3\u8005\u7684\u4ee3\u8c22\u6307\u6807\u6709\u6240\u6539\u5584\u3002<\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\">\u77ed\u6682\u6027\u8179\u75db\uff1b\u7a7f\u523a\u90e8\u4f4d\u51fa\u8840\uff1b\u4e0a\u547c\u5438\u9053\u611f\u67d3<\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\">\u968f\u673a\u3001\u5bf9\u7167\u3001\u5f00\u653e\u6807\u7b7e\u7814\u7a76<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>MSC\u6cbb\u7597T1DM\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u5df2\u5728\u52a8\u7269\u5b9e\u9a8c\u4e2d\u5f97\u5230\u9a8c\u8bc1\uff0c\u76ee\u524d\u6b63\u5904\u4e8e\u5c0f\u6837\u672c\u4e34\u5e8a\u8bd5\u9a8c\u9636\u6bb5\u3002\u8bb8\u591a\u76f8\u5173\u7814\u7a76\u5df2\u7ecf\u542f\u52a8\u6216\u6b63\u5728\u8fdb\u884c\u4e2d\u3002<\/p>\n<h3 id=\"sec-0004-title\" class=\"article-section__sub-title section2\"><span class=\"ez-toc-section\" id=\"22_MSC%E7%96%97%E6%B3%95%E6%B2%BB%E7%96%972%E5%9E%8B%E7%B3%96%E5%B0%BF%E7%97%85%E7%9A%84%E4%B8%B4%E5%BA%8A%E7%A0%94%E7%A9%B6\"><\/span><span dir=\"auto\">2.2. <\/span><span dir=\"auto\">MSC\u7597\u6cd5\u6cbb\u75972\u578b\u7cd6\u5c3f\u75c5\u7684\u4e34\u5e8a\u7814\u7a76<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span dir=\"auto\">2\u578b\u7cd6\u5c3f\u75c5\uff08T2DM\uff09\u662f\u7531\u514d\u75ab\u529f\u80fd\u969c\u788d\u548c\u708e\u75c7\u5f15\u8d77\u7684\uff0c\u800c\u514d\u75ab\u529f\u80fd\u969c\u788d\u548c\u708e\u75c7\u53ef\u80fd\u662fT2DM\u4e2d\u80f0\u5c9b\u7d20\u62b5\u6297\u53d1\u5c55\u7684\u5173\u952e\u56e0\u7d20\u3002\u636e\u62a5\u9053\uff0c\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSC\uff09\u7597\u6cd5\u6709\u671b\u6709\u6548\u6cbb\u6108\u7cd6\u5c3f\u75c5\u5e76\u6539\u5584\u80f0\u5c9b\u7d20\u62b5\u6297\uff0c\u8fd9\u5df2\u5728\u52a8\u7269\u8bd5\u9a8c\u4e2d\u5f97\u5230\u9a8c\u8bc1<\/span><span dir=\"auto\">The<\/span><\/p>\n<p><span dir=\"auto\">\u6b64\u5916\uff0c\u622a\u81f32025\u5e7410\u6708\uff0cClinicalTrials.gov\uff08<a class=\"linkBehavior\" href=\"http:\/\/www.clinicaltrials.gov\/\" rel=\"nofollow noopener\" target=\"_blank\">http:\/\/www.clinicaltrials.gov \uff09\u6536\u5f55\u4e8621\u9879\u5173\u4e8eMSC\u7597\u6cd5<\/a><\/span><a id=\"bib-0051_R_d193811385e1047\" class=\"bibLink tab-link\" href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2021\/9938658#bib-0051\" data-tab=\"pane-pcw-references\" aria-label=\"\u53c2\u8003\u6587\u732e51 - BMC\u517d\u533b\u7814\u7a76\" rel=\"nofollow noopener\" target=\"_blank\"><span dir=\"auto\">\u7684<\/span><\/a><span dir=\"auto\">\u4e34\u5e8a\u7814\u7a76\uff0c\u5176\u4e2d7\u9879\u5df2\u5b8c\u6210\u3002\u88683\u5217\u51fa\u4e86\u5df2\u53d1\u8868\u7684\u5173\u4e8e\u79fb\u690dMSC\u6cbb\u7597T2DM\u7684\u6587\u732e\u3002\u5728\u8fd9\u4e9b\u5df2\u53d1\u8868\u7684\u7814\u7a76\u4e2d\uff0c\u5df2\u8bc1\u5b9eMSC\u7597\u6cd5\u53ef\u4ee5\u6709\u6548\u964d\u4f4e\u7a7a\u8179\u8840\u7cd6\uff08FBG\uff09\u3001\u9910\u540e\u8840\u7cd6\uff08PBG\uff09\u548c\u7cd6\u5316\u8840\u7ea2\u86cb\u767d\uff08HbA1c\uff09\u6c34\u5e73\uff0c\u51cf\u5c11\u80f0\u5c9b\u7d20\u9700\u6c42\uff0c\u5e76\u5728\u968f\u8bbf\u671f\u95f4\u6539\u5584\u80f0\u5c9b\u7d20\u62b5\u6297\uff0c\u8bc1\u660eMSC\u7597\u6cd5\u5728\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u5177\u6709\u663e\u8457\u7597\u6548\u3002<\/span><\/p>\n<p><span dir=\"auto\">\u5728\u8fd9\u4e9b\u4e34\u5e8a\u8bc4\u4f30\u4e2d\uff0c\u4e5f\u89c2\u5bdf\u5230\u4e00\u4e9b\u526f\u4f5c\u7528\uff0c\u5305\u62ec\u53d1\u70ed\u3001\u76ae\u4e0b\u8840\u80bf\u3001\u6076\u5fc3\u3001\u5455\u5410\u3001\u5934\u75db\u548c\u8f7b\u5ea6\u4f4e\u8840\u7cd6\uff1b\u5e78\u8fd0\u7684\u662f\uff0c\u8fd9\u4e9b\u60a3\u8005\u5728\u63a5\u53d7\u5bf9\u75c7\u6cbb\u7597\u540e\u75c7\u72b6\u5373\u53ef\u7f13\u89e3\uff0c\u4e14\u65e0\u4e25\u91cd\u5e76\u53d1\u75c7\u6216\u526f\u4f5c\u7528\u3002\u7136\u800c\uff0c\u8fd9\u4e9b\u7814\u7a76\u7684\u968f\u8bbf\u65f6\u95f4\u5747\u4ec5\u4e3a12\u4e2a\u6708\uff0c\u4e0d\u8db3\u4ee5\u8fdb\u884c\u957f\u671f\u526f\u4f5c\u7528\u548c\u5e76\u53d1\u75c7\u7684\u8bc4\u4f30\u3002\u5c3d\u7ba1\u9762\u4e34\u8bf8\u591a\u6311\u6218\uff0c\u4f46\u76ee\u524d\u4ee4\u4eba\u6b23\u6170\u548c\u9f13\u821e\u7684\u7ed3\u679c\u8868\u660e\uff0c\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u7597\u6cd5\u662f\u4e00\u79cd\u5f88\u6709\u524d\u666f\u76842\u578b\u7cd6\u5c3f\u75c5\u6cbb\u7597\u65b9\u6cd5\uff0c\u9884\u793a\u7740\u7cd6\u5c3f\u75c5\u6cbb\u7597\u65b0\u65f6\u4ee3\u7684\u5230\u6765\u3002<\/span><\/p>\n<table class=\"table article-section__table\">\n<thead>\n<tr>\n<th class=\"right-bordered-cell left-aligned\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u53d1\u5e03<\/span><\/span><\/span><\/th>\n<th class=\"center-aligned\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7ec6\u80de\u8d44\u6e90<\/span><\/span><\/span><\/th>\n<th class=\"center-aligned\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6ce8\u5c04\u6cd5<\/span><\/span><\/span><\/th>\n<th class=\"center-aligned\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6ce8\u5c04\u5242\u91cf<\/span><\/span><\/span><\/th>\n<th class=\"center-aligned\"><span dir=\"auto\">\u6ce8\u5c04\u6b21\u6570<\/span><\/th>\n<th class=\"center-aligned\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u540e\u7eed\u65f6\u95f4<\/span><\/span><\/span><\/th>\n<th class=\"center-aligned\"><span dir=\"auto\">\u529f\u6548\u8bc4\u4ef7\u6307\u6570<\/span><\/th>\n<th class=\"center-aligned\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7ed3\u679c<\/span><\/span><\/span><\/th>\n<th class=\"center-aligned\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e0d\u826f\u4e8b\u4ef6<\/span><\/span><\/span><\/th>\n<th class=\"center-aligned\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7814\u7a76\u8bbe\u8ba1<\/span><\/span><\/span><\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td class=\"right-bordered-cell left-aligned\"><span dir=\"auto\">Liu \u7b49\u4eba[\u00a0<\/span><a id=\"bib-0042_R_d193811385e1139\" class=\"bibLink tab-link\" href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2021\/9938658#bib-0042\" data-tab=\"pane-pcw-references\" aria-label=\"\u53c2\u8003\u6587\u732e42 - \u5e72\u7ec6\u80de\u7814\u7a76\u4e0e\u6cbb\u7597\" rel=\"nofollow noopener\" target=\"_blank\"><span dir=\"auto\">42<\/span><\/a><span dir=\"auto\">\u00a0]<\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">WJ-MSC<\/span><\/span><\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\">\u813e\u52a8\u8109\u6ce8\u5c04\uff1b\u9759\u8109\u6ce8\u5c04<\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\">1 \u00d7 10^6 \u4e2a\u7ec6\u80de\/\u5343\u514b<\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\">\u4e24\u6b21<\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">12\u4e2a\u6708<\/span><\/span><\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\">\u7cd6\u5316\u8840\u7ea2\u86cb\u767d\u3001C\u80bd\u3001\u7a7a\u8179\u8840\u7cd6\u3001\u9910\u524d\u8840\u7cd6\u3001\u80f0\u5c9b\u7d20\u9700\u6c42\u91cf\u3001\u708e\u75c7\u6807\u5fd7\u7269\u3001T\u6dcb\u5df4\u7ec6\u80de\u8ba1\u6570<\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\">WJ-MSC \u79fb\u690d\u663e\u8457\u964d\u4f4e\u4e86\u8461\u8404\u7cd6\u548c\u7cd6\u5316\u8840\u7ea2\u86cb\u767d\u6c34\u5e73\uff0c\u6539\u5584\u4e86 C \u80bd\u6c34\u5e73\u548c \u03b2 \u7ec6\u80de\u529f\u80fd\uff0c\u5e76\u964d\u4f4e\u4e86\u5168\u8eab\u708e\u75c7\u6807\u5fd7\u7269\u548c T \u6dcb\u5df4\u7ec6\u80de\u8ba1\u6570\u3002<\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\">\u53d1\u70ed\u3001\u76ae\u4e0b\u8840\u80bf\u3001\u6076\u5fc3\u3001\u5455\u5410\u548c\u5934\u75db<\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\">\u5f00\u653e\u6807\u7b7e\u3001\u5355\u4e2d\u5fc3\u3001\u975e\u968f\u673a\u7814\u7a76<\/span><\/td>\n<\/tr>\n<tr>\n<td class=\"bottom-bordered-cell left-aligned\" colspan=\"10\"><\/td>\n<\/tr>\n<tr>\n<td class=\"right-bordered-cell left-aligned\"><span dir=\"auto\">Bhansali\u7b49\u4eba[\u00a0<\/span><a id=\"bib-0043_R_d193811385e1182\" class=\"bibLink tab-link\" href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2021\/9938658#bib-0043\" data-tab=\"pane-pcw-references\" aria-label=\"\u53c2\u8003\u6587\u732e43 - \u7ec6\u80de\u79fb\u690d\" rel=\"nofollow noopener\" target=\"_blank\"><span dir=\"auto\">43<\/span><\/a><span dir=\"auto\">\u00a0]<\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u81ea\u4f53\u9aa8\u9ad3\u95f4\u5145\u8d28\u5e72\u7ec6\u80de<\/span><\/span><\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\">\u80f0\u4e0a\u52a8\u8109\u6ce8\u5c04\uff1b\u8098\u524d\u9759\u8109\u6ce8\u5c04<\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\">1 \u00d7 10^6 \u4e2a\u7ec6\u80de\/\u5343\u514b<\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\">\u4e24\u6b21<\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\">12\u4e2a\u6708<\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\">\u80f0\u5c9b\u7d20\u9700\u6c42\u91cf\u3001\u7cd6\u5316\u8840\u7ea2\u86cb\u767d (HbA1c)\u3001C\u80bd<\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\">BM-MSC \u7597\u6cd5\u663e\u8457\u964d\u4f4e\u4e86 2 \u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u7684\u80f0\u5c9b\u7d20\u5242\u91cf\u9700\u6c42\uff0c\u5e76\u6539\u5584\u4e86\u523a\u6fc0\u6027 C \u80bd\u6c34\u5e73\u3002<\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\">\u65e0\u660e\u663e\u4e0d\u826f\u53cd\u5e94<\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\">\u968f\u673a\u3001\u5355\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u7814\u7a76<\/span><\/td>\n<\/tr>\n<tr>\n<td class=\"bottom-bordered-cell left-aligned\" colspan=\"10\"><\/td>\n<\/tr>\n<tr>\n<td class=\"right-bordered-cell center-aligned\"><span dir=\"auto\">Bhansali \u7b49\u4eba[\u00a0<\/span><a id=\"bib-0044_R_d193811385e1225\" class=\"bibLink tab-link\" href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2021\/9938658#bib-0044\" data-tab=\"pane-pcw-references\" aria-label=\"\u53c2\u8003\u6587\u732e 44 - \u5e72\u7ec6\u80de\u4e0e\u53d1\u80b2\" rel=\"nofollow noopener\" target=\"_blank\"><span dir=\"auto\">44<\/span><\/a><span dir=\"auto\">\u00a0]<\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\">\u81ea\u4f53\u9aa8\u9ad3\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u548c\u81ea\u4f53\u9aa8\u9ad3\u5355\u6838\u7ec6\u80de<\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u80f0\u4e0a\u52a8\u8109\u6ce8\u5c04\uff1b\u8098\u524d\u9759\u8109\u6ce8\u5c04<\/span><\/span><\/span><\/td>\n<td class=\"center-aligned\">\n<ol class=\"\" start=\"1\">\n<li><span dir=\"auto\">\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff1a1 \u00d7 10^6 \u4e2a\u7ec6\u80de\/\u5343\u514b<\/span><\/li>\n<li><span dir=\"auto\">\u5355\u6838\u7ec6\u80de\uff1a1 \u00d7 10^9 \u4e2a\u7ec6\u80de\/\u5343\u514b<\/span><\/li>\n<\/ol>\n<\/td>\n<td class=\"center-aligned\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e24\u6b21<\/span><\/span><\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">12\u4e2a\u6708<\/span><\/span><\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\">ISI\u3001\u80f0\u5c9b\u7d20\u3001HbA1c\u3001C\u80bd\u3001HOMA-IR\u3001HOMA &#8211;\u00a0<\/span><i><span dir=\"auto\">\u03b2<\/span><\/i><span dir=\"auto\">\u3001HOMA-S\u3001GLUT-4\u3001IRS-1<\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\">\u81ea\u4f53\u9aa8\u9ad3\u95f4\u5145\u8d28\u5e72\u7ec6\u80de (BM-MSC) \u548c\u81ea\u4f53\u9aa8\u9ad3\u5355\u6838\u7ec6\u80de (BM-MNC) \u5747\u53ef\u4f7f 2 \u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u6301\u7eed\u51cf\u5c11\u80f0\u5c9b\u7d20\u7528\u91cf\uff0c\u5176\u4e2d MSC \u53ef\u6539\u5584\u80f0\u5c9b\u7d20\u654f\u611f\u6027\uff0c\u800c MNC \u53ef\u589e\u52a0 C \u80bd\u53cd\u5e94\u3002<\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\">\u6076\u5fc3\u5455\u5410\u3001\u5c40\u90e8\u5916\u6e17\u3001\u8f7b\u5ea6\u4f4e\u8840\u7cd6<\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u968f\u673a\u3001\u5355\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u7814\u7a76<\/span><\/span><\/span><\/td>\n<\/tr>\n<tr>\n<td class=\"bottom-bordered-cell left-aligned\" colspan=\"10\"><\/td>\n<\/tr>\n<tr>\n<td class=\"right-bordered-cell left-aligned\"><span dir=\"auto\">Kong \u7b49\u4eba[\u00a0<\/span><a id=\"bib-0045_R_d193811385e1276\" class=\"bibLink tab-link\" href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2021\/9938658#bib-0045\" data-tab=\"pane-pcw-references\" aria-label=\"\u53c2\u8003\u6587\u732e 45 - \u4e34\u5e8a\u5b9e\u9a8c\u5ba4\" rel=\"nofollow noopener\" target=\"_blank\"><span dir=\"auto\">45<\/span><\/a><span dir=\"auto\">\u00a0]<\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">UC-MSC<\/span><\/span><\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\">\u9759\u8109\u6ce8\u5c04<\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">1 \u00d7 10^6 \u4e2a\u7ec6\u80de\/\u5343\u514b<\/span><\/span><\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\">\u4e09\u6b21<\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\">6\u4e2a\u6708<\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\">FPG\u3001PBG\u3001HbA1c\u3001C\u80bd\u3001T\u7ec6\u80de\u4e9a\u7fa4<\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\">\u7597\u6548\u7ec4\u60a3\u8005\u7684 FBG \u548c PBG \u5728 UMSC \u8f93\u8840\u540e\u663e\u8457\u964d\u4f4e\u3002<\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\">\u8f7b\u5fae\u77ed\u6682\u53d1\u70ed<\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u968f\u673a\u3001\u5355\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u7814\u7a76<\/span><\/span><\/span><\/td>\n<\/tr>\n<tr>\n<td class=\"bottom-bordered-cell left-aligned\" colspan=\"10\"><\/td>\n<\/tr>\n<tr>\n<td class=\"right-bordered-cell center-aligned\"><span dir=\"auto\">Chen \u7b49\u4eba[\u00a0<\/span><a id=\"bib-0046_R_d193811385e1319\" class=\"bibLink tab-link\" href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2021\/9938658#bib-0046\" data-tab=\"pane-pcw-references\" aria-label=\"\u7b2c46\u96c6-\u4e2d\u534e\u5185\u79d1\u6742\u5fd7\" rel=\"nofollow noopener\" target=\"_blank\"><span dir=\"auto\">46<\/span><\/a><span dir=\"auto\">\u00a0]<\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">UC-MSC<\/span><\/span><\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u80f0\u4e0a\u52a8\u8109\u6ce8\u5c04\uff1b\u8098\u524d\u9759\u8109\u6ce8\u5c04<\/span><\/span><\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">1 \u00d7 10^6 \u4e2a\u7ec6\u80de\/\u5343\u514b<\/span><\/span><\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\">\u56db\u6b21<\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">6\u4e2a\u6708<\/span><\/span><\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\">FPG\u3001PBG\u3001HbA1c\u3001C\u80bd\u3001HOMA-IR<\/span><\/td>\n<td class=\"center-aligned\">\n<ol class=\"\" start=\"1\">\n<li><span dir=\"auto\">MSCs\u7ec4\u7684FPG\u30012hPG\u548cHbA1c\u6c34\u5e73\u663e\u8457\u6539\u5584\u3002<\/span><\/li>\n<li><span dir=\"auto\">\u5229\u62c9\u9c81\u80bd\u8054\u5408 hUC-MSCs \u6cbb\u7597\u53ef\u6539\u5584 2 \u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u7684\u8461\u8404\u7cd6\u4ee3\u8c22\u548c<\/span><i><span dir=\"auto\">\u03b2<\/span><\/i><span dir=\"auto\">\u7ec6\u80de\u529f\u80fd\u3002<\/span><\/li>\n<\/ol>\n<\/td>\n<td class=\"center-aligned\"><span dir=\"auto\">\u4f4e\u8840\u7cd6\u4e8b\u4ef6<\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u968f\u673a\u3001\u5355\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u7814\u7a76<\/span><\/span><\/span><\/td>\n<\/tr>\n<tr>\n<td class=\"bottom-bordered-cell left-aligned\" colspan=\"10\"><\/td>\n<\/tr>\n<tr>\n<td class=\"right-bordered-cell left-aligned\"><span dir=\"auto\">Skyler \u7b49\u4eba[\u00a0<\/span><a id=\"bib-0047_R_d193811385e1370\" class=\"bibLink tab-link\" href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2021\/9938658#bib-0047\" data-tab=\"pane-pcw-references\" aria-label=\"\u53c2\u8003\u6587\u732e 47 - \u7cd6\u5c3f\u75c5\u62a4\u7406\" rel=\"nofollow noopener\" target=\"_blank\"><span dir=\"auto\">47<\/span><\/a><span dir=\"auto\">\u00a0]<\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\">\u5f02\u57fa\u56e0\u9aa8\u9ad3-MPS<\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\">\u9759\u8109\u8f93\u6db2<\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\">0.3\/1\/2 \u00d7 10^6 \u4e2a\u7ec6\u80de\/\u5343\u514b<\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\">\u4e00\u6b21<\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\">12\u5468<\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\">\u7cd6\u5316\u8840\u7ea2\u86cb\u767d (HbA1c)\u3001\u7a7a\u8179\u8840\u7cd6 (FPG)<\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\">\u5728\u7b2c 12 \u5468\uff0cHbA1c \u76ee\u6807 &lt;7% \u5206\u522b\u8fbe\u5230 13.3%\u30016.7%\u300133.3%\uff1b\u5728\u7b2c 12 \u5468\uff0c\u5404\u6cbb\u7597\u7ec4\u7684 FPG \u5747\u672a\u663e\u793a\u51fa\u8d8b\u52bf\u3002<\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\">\u65e0\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6<\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\">\u591a\u4e2d\u5fc3\u3001\u968f\u673a\u3001\u5355\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u8bd5\u9a8c<\/span><\/td>\n<\/tr>\n<tr>\n<td class=\"bottom-bordered-cell left-aligned\" colspan=\"10\"><\/td>\n<\/tr>\n<tr>\n<td class=\"right-bordered-cell left-aligned\"><span dir=\"auto\">Jiang\u7b49\u4eba[\u00a0<\/span><a id=\"bib-0048_R_d193811385e1414\" class=\"bibLink tab-link\" href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2021\/9938658#bib-0048\" data-tab=\"pane-pcw-references\" aria-label=\"\u53c2\u8003\u6587\u732e 48 - \u533b\u5b66\u524d\u6cbf\" rel=\"nofollow noopener\" target=\"_blank\"><span dir=\"auto\">48<\/span><\/a><span dir=\"auto\">\u00a0]<\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\">\u80ce\u76d8\u95f4\u5145\u8d28\u5e72\u7ec6\u80de<\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u9759\u8109\u8f93\u6db2<\/span><\/span><\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\">1.35 \u00d7 10^6 \u4e2a\u7ec6\u80de\/\u5343\u514b<\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e09\u6b21<\/span><\/span><\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">6\u4e2a\u6708<\/span><\/span><\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\">\u80f0\u5c9b\u7d20\u9700\u6c42\u91cf\u3001C\u80bd\u3001\u7cd6\u5316\u8840\u7ea2\u86cb\u767d<\/span><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\">\u6cbb\u7597\u540e\uff0c\u6bcf\u65e5\u5e73\u5747\u80f0\u5c9b\u7d20\u9700\u6c42\u91cf\u51cf\u5c11\uff0cC\u80bd\u6c34\u5e73\u5347\u9ad8\u3002<\/span><\/td>\n<td class=\"center-aligned\"><\/td>\n<td class=\"center-aligned\"><span dir=\"auto\">\u975e\u968f\u673a\u7814\u7a76<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><span class=\"table-caption__label\"><span dir=\"auto\">\u8868 3.\u00a0<\/span><\/span><span dir=\"auto\">MSC \u6cbb\u7597 2 \u578b\u7cd6\u5c3f\u75c5\u7684\u4e34\u5e8a\u7814\u7a76\u3002<\/span><\/p>\n<h2><span class=\"ez-toc-section\" id=\"%E4%B8%89%E3%80%81%E9%97%B4%E5%85%85%E8%B4%A8%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E7%B3%96%E5%B0%BF%E7%97%85%E7%9A%84%E4%BD%9C%E7%94%A8%E6%9C%BA%E5%88%B6\"><\/span>\u4e09\u3001\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6cbb\u7597\u7cd6\u5c3f\u75c5\u7684\u4f5c\u7528\u673a\u5236<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<h3 class=\"ds-markdown-paragraph\"><span class=\"ez-toc-section\" id=\"%E7%9B%B4%E6%8E%A5%E4%BD%9C%E7%94%A8%E4%B8%8E%E6%A0%B9%E6%9C%AC%E7%9B%AE%E6%A0%87%E2%80%94%E2%80%94%E6%9B%BF%E4%BB%A3%E4%B8%8E%E4%BF%AE%E5%A4%8D%CE%B2%E7%BB%86%E8%83%9E\"><\/span><strong>\u76f4\u63a5\u4f5c\u7528\u4e0e\u6839\u672c\u76ee\u6807\u2014\u2014\u66ff\u4ee3\u4e0e\u4fee\u590d\u03b2\u7ec6\u80de<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p class=\"ds-markdown-paragraph\">\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6cbb\u7597\u7cd6\u5c3f\u75c5\u6700\u76f4\u63a5\u7684\u673a\u5236\u662f\u5176\u80fd\u591f\u88ab\u8bf1\u5bfc\u5206\u5316\u4e3a\u80f0\u5c9b\u7d20\u5206\u6ccc\u7ec6\u80de\uff08IPCs\uff09\uff0c\u4ece\u800c\u76f4\u63a5\u66ff\u4ee3\u88ab\u7834\u574f\u6216\u529f\u80fd\u8870\u7aed\u7684\u80f0\u5c9b\u03b2\u7ec6\u80de\uff0c\u5f25\u8865\u80f0\u5c9b\u7d20\u5206\u6ccc\u7684\u4e0d\u8db3\uff0c\u8fd9\u662f\u5b9e\u73b0\u8840\u7cd6\u63a7\u5236\u7684\u6839\u672c\u9014\u5f84\u3002\u6b64\u5916\uff0cMSCs\u8fd8\u80fd\u901a\u8fc7\u5f52\u5de2\u81f3\u80f0\u817a\uff0c\u4fc3\u8fdb\u5185\u6e90\u6027\u80f0\u5c9b\u7684\u4fee\u590d\u4e0e\u518d\u751f\uff0c\u5177\u4f53\u8868\u73b0\u4e3a\u589e\u52a0\u80f0\u5c9b\u7684\u6570\u91cf\u548c\u4f53\u79ef\uff0c\u5e76\u6062\u590d\u80f0\u5c9b\u7d20\u9633\u6027\u7ec6\u80de\u7684\u6bd4\u4f8b\u3002\u66f4\u6709\u7814\u7a76\u53d1\u73b0\uff0cMSCs\u80fd\u901a\u8fc7\u5206\u6cccIL-1Ra\u7b49\u56e0\u5b50\uff0c\u9006\u8f6c\u03b2\u7ec6\u80de\u5728\u75c5\u7406\u72b6\u6001\u4e0b\u7684\u201c\u53bb\u5206\u5316\u201d\u8fc7\u7a0b\uff0c\u5e2e\u52a9\u5176\u6062\u590d\u6210\u719f\u7684\u5206\u6ccc\u8868\u578b\uff0c\u4ece\u800c\u4ece\u591a\u4e2a\u5c42\u9762\u633d\u6551\u548c\u589e\u5f3a\u03b2\u7ec6\u80de\u529f\u80fd\u3002<\/p>\n<h3 class=\"ds-markdown-paragraph\"><span class=\"ez-toc-section\" id=\"%E9%97%B4%E6%8E%A5%E4%BD%9C%E7%94%A8%E4%B8%8E%E5%8D%8F%E5%90%8C%E5%A2%9E%E6%95%88%E2%80%94%E2%80%94%E6%94%B9%E5%96%84%E7%8E%AF%E5%A2%83%E4%B8%8E%E8%B0%83%E8%8A%82%E5%85%8D%E7%96%AB\"><\/span><strong>\u95f4\u63a5\u4f5c\u7528\u4e0e\u534f\u540c\u589e\u6548\u2014\u2014\u6539\u5584\u73af\u5883\u4e0e\u8c03\u8282\u514d\u75ab<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p class=\"ds-markdown-paragraph\">\u9664\u4e86\u76f4\u63a5\u4f5c\u7528\u4e8e\u03b2\u7ec6\u80de\uff0cMSCs\u66f4\u53d1\u6325\u7740\u5f3a\u5927\u7684\u95f4\u63a5\u8c03\u63a7\u4f5c\u7528\uff0c\u8fd9\u5bf9\u4e8e2\u578b\u7cd6\u5c3f\u75c5\u5c24\u4e3a\u5173\u952e\u3002\u5176\u6838\u5fc3\u5728\u4e8e\u901a\u8fc7\u5f3a\u5927\u7684\u6297\u708e\u4e0e\u514d\u75ab\u8c03\u8282\u80fd\u529b\u6765\u6539\u5584\u80f0\u5c9b\u7d20\u62b5\u6297\uff08IR\uff09\u3002MSCs\u80fd\u591f\u4e0a\u8c03\u80f0\u5c9b\u7d20\u4fe1\u53f7\u901a\u8def\u4e2d\u7684\u5173\u952e\u86cb\u767d\uff08\u5982GLUT4\u3001IRS-1\u3001AKT\uff09\uff0c\u63d0\u5347\u7ec4\u7ec7\u5bf9\u80f0\u5c9b\u7d20\u7684\u654f\u611f\u6027\uff1b\u540c\u65f6\uff0c\u5b83\u4eec\u80fd\u8c03\u8282\u5de8\u566c\u7ec6\u80de\u4ece\u4fc3\u708e\u7684M1\u578b\u5411\u6297\u708e\u7684M2\u578b\u6781\u5316\uff0c\u5e76\u7cfb\u7edf\u6027\u5730\u964d\u4f4eTNF-\u03b1\u3001IL-6\u7b49\u708e\u75c7\u56e0\u5b50\u6c34\u5e73\uff0c\u63d0\u5347\u8102\u8054\u7d20\u7b49\u6297\u708e\u56e0\u5b50\u6c34\u5e73\uff0c\u4ece\u800c\u6253\u7834\u6162\u6027\u708e\u75c7\u4e0e\u80f0\u5c9b\u7d20\u62b5\u6297\u7684\u6076\u6027\u5faa\u73af\uff0c\u4e3a\u8840\u7cd6\u7a33\u5b9a\u521b\u9020\u6709\u5229\u7684\u4f53\u5185\u73af\u5883\u3002<span dir=\"auto\">\u56fe<\/span><span dir=\"auto\">1<\/span><span dir=\"auto\">\u603b\u7ed3\u4e86MSCs\u6cbb\u7597\u7cd6\u5c3f\u75c5\u7684\u5404\u79cd\u673a\u5236\u3002<\/span><\/p>\n<div id=\"attachment_20209\" style=\"width: 610px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-20209\" class=\"wp-image-20209 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/\u5fae\u4fe1\u56fe\u7247_2025-10-30_125848_952.png\" alt=\"\u56fe1\uff1a\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6cbb\u7597\u7cd6\u5c3f\u75c5\u7684\u673a\u5236\" width=\"600\" height=\"370\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/\u5fae\u4fe1\u56fe\u7247_2025-10-30_125848_952.png 600w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/\u5fae\u4fe1\u56fe\u7247_2025-10-30_125848_952-300x185.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/10\/\u5fae\u4fe1\u56fe\u7247_2025-10-30_125848_952-18x12.png 18w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><p id=\"caption-attachment-20209\" class=\"wp-caption-text\">\u56fe1\uff1a\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6cbb\u7597\u7cd6\u5c3f\u75c5\u7684\u673a\u5236<\/p><\/div>\n<h2 class=\"ds-markdown-paragraph\"><span class=\"ez-toc-section\" id=\"%E5%9B%9B%E3%80%81%E6%80%BB%E7%BB%93%E6%A0%B8%E5%BF%83%E6%B2%BB%E7%96%97%E6%BD%9C%E5%8A%9B%E4%B8%8E%E6%9C%BA%E5%88%B6\"><\/span><strong>\u56db\u3001\u603b\u7ed3\u6838\u5fc3\u6cbb\u7597\u6f5c\u529b\u4e0e\u673a\u5236<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p class=\"ds-markdown-paragraph\">\u7efc\u4e0a\u6240\u8ff0\uff0c\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u901a\u8fc7\u5176\u72ec\u7279\u7684\u514d\u75ab\u6291\u5236\u4e0e\u591a\u91cd\u4fee\u590d\u529f\u80fd\uff0c\u4e3a\u7cd6\u5c3f\u75c5\u6cbb\u7597\u63d0\u4f9b\u4e86\u5145\u6ee1\u524d\u666f\u7684\u7b56\u7565\u3002\u5176\u4f5c\u7528\u4e0d\u4ec5\u9650\u4e8e\u5206\u5316\u4e3a\u80f0\u5c9b\u7d20\u5206\u6ccc\u7ec6\u80de\u6765\u76f4\u63a5\u8865\u5145\u03b2\u7ec6\u80de\uff0c\u66f4\u5173\u952e\u5728\u4e8e\u80fd\u901a\u8fc7\u5206\u6ccc\u591a\u79cd\u7ec6\u80de\u56e0\u5b50\uff0c\u6539\u5584\u80f0\u817a\u5fae\u73af\u5883\u3001\u9776\u5411\u51cf\u8f7b\u80f0\u5c9b\u7d20\u62b5\u6297\u3001\u5e76\u4fdd\u62a4\u4e0e\u518d\u751f\u5185\u6e90\u6027\u80f0\u5c9b\u03b2\u7ec6\u80de\uff0c\u4ece\u800c\u5b9e\u73b0\u8840\u7cd6\u7684\u957f\u671f\u7a33\u5b9a\u3002\u8fd9\u4f7f\u5f97MSCs\u7597\u6cd5\u65e2\u80fd\u9488\u5bf91\u578b\u7cd6\u5c3f\u75c5\u7684\u81ea\u8eab\u514d\u75ab\u6839\u6e90\u53d1\u6325\u8c03\u8282\u4f5c\u7528\uff0c\u4e5f\u80fd\u901a\u8fc7\u6297\u708e\u548c\u6539\u5584\u80f0\u5c9b\u7d20\u62b5\u6297\u6765\u6709\u6548\u63a7\u52362\u578b\u7cd6\u5c3f\u75c5\uff0c\u90e8\u5206\u60a3\u8005\u751a\u81f3\u53ef\u5728\u4e00\u6bb5\u65f6\u95f4\u5185\u8131\u79bb\u5916\u6e90\u6027\u80f0\u5c9b\u7d20\u6216\u53e3\u670d\u964d\u7cd6\u836f\u3002<\/p>\n<h3 class=\"ds-markdown-paragraph\"><span class=\"ez-toc-section\" id=\"%E8%BE%A8%E6%9E%90%E5%BD%93%E5%89%8D%E9%9D%A2%E4%B8%B4%E7%9A%84%E4%B8%B4%E5%BA%8A%E9%80%89%E6%8B%A9%E4%B8%8E%E6%8C%91%E6%88%98\"><\/span><strong>\u8fa8\u6790\u5f53\u524d\u9762\u4e34\u7684\u4e34\u5e8a\u9009\u62e9\u4e0e\u6311\u6218<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p class=\"ds-markdown-paragraph\">\u7136\u800c\uff0c\u5728\u8fc8\u5411\u5e7f\u6cdb\u4e34\u5e8a\u5e94\u7528\u7684\u8fdb\u7a0b\u4e2d\uff0c\u4ecd\u6709\u82e5\u5e72\u5173\u952e\u95ee\u9898\u4e9f\u5f85\u660e\u786e\u3002\u9996\u8981\u95ee\u9898\u5728\u4e8e\u6cbb\u7597\u7b56\u7565\u7684\u9009\u62e9\uff1a\u662f\u79fb\u690d\u672a\u5206\u5316\u7684MSCs\u8fd8\u662f\u5176\u8bf1\u5bfc\u540e\u7684\u80f0\u5c9b\u7d20\u5206\u6ccc\u7ec6\u80de\uff1f\u7814\u7a76\u8868\u660e\uff0cMSCs\u56e0\u5176\u66f4\u5f3a\u7684\u514d\u75ab\u8c03\u8282\u80fd\u529b\uff0c\u53ef\u80fd\u5728\u9632\u6cbb1\u578b\u7cd6\u5c3f\u75c5\u65b9\u9762\u66f4\u5177\u4f18\u52bf\u3002\u5176\u6b21\uff0c\u7ec6\u80de\u6765\u6e90\u7684\u9009\u62e9\u4e5f\u81f3\u5173\u91cd\u8981\uff1a\u6765\u81ea2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u7684\u81ea\u4f53MSCs\u53ef\u80fd\u5b58\u5728\u529f\u80fd\u53d7\u635f\uff0c\u800c\u5f02\u4f53\u6765\u6e90\uff08\u5982\u8110\u5e26MSCs\uff09\u867d\u6d3b\u6027\u66f4\u4f73\uff0c\u5374\u53c8\u9762\u4e34\u79fb\u690d\u540e\u53ef\u80fd\u4e27\u5931\u514d\u75ab\u8c41\u514d\u7279\u6027\u800c\u5f15\u53d1\u6392\u65a5\u7684\u98ce\u9669\u3002\u8fd9\u4e9b\u6289\u62e9\u5747\u9700\u5ba1\u614e\u8bc4\u4f30\u3002<\/p>\n<h3 class=\"ds-markdown-paragraph\"><span class=\"ez-toc-section\" id=\"%E6%8C%87%E6%98%8E%E6%9C%AA%E6%9D%A5%E5%8F%91%E5%B1%95%E6%96%B9%E5%90%91%E4%B8%8E%E8%A6%81%E6%B1%82\"><\/span><strong>\u6307\u660e\u672a\u6765\u53d1\u5c55\u65b9\u5411\u4e0e\u8981\u6c42<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p class=\"ds-markdown-paragraph\">\u56e0\u6b64\uff0c\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6cbb\u7597\u7cd6\u5c3f\u75c5\u8981\u6210\u4e3a\u6807\u51c6\u5316\u4e34\u5e8a\u65b9\u6848\uff0c\u672a\u6765\u5fc5\u987b\u4f9d\u9760\u591a\u4e2d\u5fc3\u3001\u5927\u6837\u672c\u7684\u5bf9\u6bd4\u7814\u7a76\u6765\u56de\u7b54\u4e0a\u8ff0\u60ac\u800c\u672a\u51b3\u7684\u95ee\u9898\u3002\u6838\u5fc3\u4efb\u52a1\u5728\u4e8e\u901a\u8fc7\u4e25\u8c28\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u7cfb\u7edf\u6bd4\u8f83\u4e0d\u540c\u7ec6\u80de\u7c7b\u578b\uff08MSCs vs. IPCs\uff09\u3001\u4e0d\u540c\u6765\u6e90\uff08\u81ea\u4f53 vs. \u5f02\u4f53\uff09\u53ca\u4e0d\u540c\u79fb\u690d\u65b9\u6848\u7684\u7597\u6548\u4e0e\u5b89\u5168\u6027\uff0c\u5e76\u6700\u7ec8\u5236\u5b9a\u51fa\u6db5\u76d6\u5177\u4f53\u64cd\u4f5c\u3001\u6ce8\u5c04\u90e8\u4f4d\u3001\u5242\u91cf\u7b49\u53d8\u91cf\u7684\u6807\u51c6\u5316\u6cbb\u7597\u89c4\u7a0b\uff0c\u4ece\u800c\u5c06\u8fd9\u4e00\u524d\u666f\u5e7f\u9614\u7684\u6cbb\u7597\u65b9\u6cd5\u5b89\u5168\u3001\u6709\u6548\u5730\u60e0\u53ca\u5e7f\u5927\u7cd6\u5c3f\u75c5\u60a3\u8005\u3002<\/p>\n<p>\u53c2\u8003\u8d44\u6599\uff1ahttps:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2021\/9938658<\/p>","protected":false},"excerpt":{"rendered":"<p>\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09\u662f\u6210\u4f53\u5e72\u7ec6\u80de\uff08ASCs\uff09\uff0c\u5177\u6709\u4fee\u590d\u53d7\u635f\u7ec6\u80de\u3001\u53d1\u6325\u6297\u708e\u53cd\u5e94\u548c\u4ea7\u751f\u514d\u75ab\u8c03\u8282\u4f5c\u7528\u7b49\u7279\u6027\uff0c\u5e76\u80fd [&hellip;]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[61],"tags":[188,178,215],"_links":{"self":[{"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/posts\/20208"}],"collection":[{"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/comments?post=20208"}],"version-history":[{"count":2,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/posts\/20208\/revisions"}],"predecessor-version":[{"id":20212,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/posts\/20208\/revisions\/20212"}],"wp:attachment":[{"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/media?parent=20208"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/categories?post=20208"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/tags?post=20208"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}