{"id":20338,"date":"2025-11-06T18:41:01","date_gmt":"2025-11-06T10:41:01","guid":{"rendered":"https:\/\/www.hjtdsm.cn\/?p=20338"},"modified":"2025-11-06T18:41:01","modified_gmt":"2025-11-06T10:41:01","slug":"%e7%a5%9e%e7%bb%8f%e5%b9%b2%e7%bb%86%e8%83%9e%e7%9a%84%e5%8f%91%e8%82%b2%e6%9c%ba%e5%88%b6","status":"publish","type":"post","link":"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/nsc\/20338.html","title":{"rendered":"\u795e\u7ecf\u5e72\u7ec6\u80de\u7684\u53d1\u80b2\u673a\u5236\u4e0e\u75be\u75c5\u5efa\u6a21"},"content":{"rendered":"<p class=\"ds-markdown-paragraph\">\u8fc7\u53bb\u56db\u5341\u5e74\u6765\uff0c\u5e72\u7ec6\u80de\u751f\u7269\u5b66\u53d6\u5f97\u4e86\u60ca\u4eba\u8fdb\u5c55\uff0c\u5f7b\u5e95\u6539\u53d8\u4e86\u79d1\u5b66\u4e0e\u533b\u5b66\u7684\u9762\u8c8c\u3002\u4f5c\u4e3a\u795e\u7ecf\u7cfb\u7edf\u7684\u5960\u57fa\u8005\uff0c\u795e\u7ecf\u5e72\u7ec6\u80de\u5728\u53d1\u80b2\u8fc7\u7a0b\u4e2d\u5206\u5316\u5f62\u6210\u6574\u4e2a\u5927\u8111\u4e0e\u810a\u9ad3\u3002\u5728\u6210\u4eba\u4f53\u5185\uff0c\u5c3d\u7ba1\u5b83\u4eec\u6570\u91cf\u7a00\u5c11\u4e14\u591a\u5904\u4e8e\u9759\u606f\u72b6\u6001\uff0c\u4f46\u5927\u91cf\u8bc1\u636e\u8868\u660e\uff0c\u8fd9\u4e9b\u7ec6\u80de\u5728\u795e\u7ecf\u53ef\u5851\u6027\u3001\u8870\u8001\u3001\u75be\u75c5\u4e0e\u518d\u751f\u4e2d\u626e\u6f14\u7740\u5173\u952e\u89d2\u8272\u3002\u795e\u7ecf\u5e72\u7ec6\u80de\u53d7\u5230\u5185\u5728\u9057\u4f20\u3001\u8868\u89c2\u9057\u4f20\u7a0b\u5e8f\u4e0e\u5916\u90e8\u5fae\u73af\u5883\u4fe1\u53f7\u7684\u53cc\u91cd\u7cbe\u5bc6\u8c03\u63a7\uff0c\u56e0\u6b64\uff0c\u5176\u529f\u80fd\u7684\u5931\u8c03\u2014\u2014\u65e0\u8bba\u662f\u6e90\u4e8e\u9057\u4f20\u56e0\u7d20\u8fd8\u662f\u73af\u5883\u5f71\u54cd\u2014\u2014\u90fd\u53ef\u80fd\u6210\u4e3a\u75be\u75c5\u7684\u6839\u6e90\u3002<\/p>\n<p class=\"ds-markdown-paragraph\">\u6b63\u56e0\u5982\u6b64\uff0c\u7406\u89e3\u795e\u7ecf\u5e72\u7ec6\u80de\u7684\u8c03\u63a7\u673a\u5236\u6210\u4e3a\u4e86\u8fc7\u53bb\u51e0\u5341\u5e74\u7684\u7814\u7a76\u7126\u70b9\u3002\u540c\u65f6\uff0c\u5b83\u4eec\u4e5f\u4e00\u76f4\u662f\u8111\u4e0e\u810a\u9ad3\u7ec6\u80de\u6cbb\u7597\u7b56\u7565\u7684\u6838\u5fc3\u3002\u7136\u800c\uff0c\u7ec4\u7ec7\u4e2d\u795e\u7ecf\u5e72\u7ec6\u80de\u7684\u6709\u9650\u6570\u91cf\u5236\u7ea6\u4e86\u5176\u4e34\u5e8a\u5e94\u7528\u3002\u5c3d\u7ba1\u80da\u80ce\u5e72\u7ec6\u80de\u548c<a href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/psc\/19896.html\/\" target=\"_blank\" rel=\"noopener\">induced pluripotent stem cell<\/a>\u7684\u6700\u65b0\u8fdb\u5c55\u4e3a\u83b7\u53d6\u795e\u7ecf\u5e72\u7ec6\u80de\u63d0\u4f9b\u4e86\u65b0\u7684\u6765\u6e90\uff0c\u6211\u4eec\u4ecd\u9762\u4e34\u7740\u8bf8\u591a\u6311\u6218\u3002<\/p>\n<p class=\"ds-markdown-paragraph\"><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC5963504\/\" target=\"_blank\" rel=\"noopener nofollow\">\u5728\u672c\u671f\u7279\u520a\u4e2d<\/a>\uff0c\u8be5\u9886\u57df\u7684\u9886\u519b\u4eba\u7269\u4e0e\u4e13\u5bb6\u4eec\u603b\u7ed3\u4e86\u5f53\u524d\u5bf9\u795e\u7ecf\u5e72\u7ec6\u80de\u53d1\u80b2\u673a\u5236\u53ca\u5206\u5b50\u8c03\u63a7\u7684\u7406\u89e3\uff0c\u5e76\u9610\u8ff0\u4e86\u5176\u5728\u75be\u75c5\u5efa\u6a21\u4e0e\u8f6c\u5316\u5e94\u7528\u4e2d\u7684\u5de8\u5927\u6f5c\u529b\u3002<\/p>\n<div id=\"attachment_20339\" style=\"width: 622px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-20339\" class=\"wp-image-20339 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/istockphoto-2196719980-612x612-1.jpg\" alt=\"\u795e\u7ecf\u5e72\u7ec6\u80de\u7684\u53d1\u80b2\u673a\u5236\u4e0e\u75be\u75c5\u5efa\u6a21\" width=\"612\" height=\"394\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/istockphoto-2196719980-612x612-1.jpg 612w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/istockphoto-2196719980-612x612-1-300x193.jpg 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/istockphoto-2196719980-612x612-1-18x12.jpg 18w\" sizes=\"(max-width: 612px) 100vw, 612px\" \/><p id=\"caption-attachment-20339\" class=\"wp-caption-text\">\u795e\u7ecf\u5e72\u7ec6\u80de\u7684\u53d1\u80b2\u673a\u5236\u4e0e\u75be\u75c5\u5efa\u6a21<\/p><\/div>\n<section id=\"S7\">\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_79_2 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewbox=\"0 0 24 24\" version=\"1.2\" baseprofile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/nsc\/20338.html\/#%E5%B9%B2%E7%BB%86%E8%83%9E%EF%BC%9A%E7%94%9F%E5%91%BD%E7%9A%84%E7%A7%8D%E5%AD%90\" >\u5e72\u7ec6\u80de\uff1a\u751f\u547d\u7684\u79cd\u5b50<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/nsc\/20338.html\/#%E7%A5%9E%E7%BB%8F%E5%B9%B2%E7%BB%86%E8%83%9E%E7%9A%84%E5%8F%91%E8%82%B2%E6%9C%BA%E5%88%B6%EF%BC%9A%E5%8F%91%E8%82%B2%E4%B8%AD%E7%9A%84%E8%BF%87%E7%A8%8B\" >\u795e\u7ecf\u5e72\u7ec6\u80de\u7684\u53d1\u80b2\u673a\u5236\uff1a\u53d1\u80b2\u4e2d\u7684\u8fc7\u7a0b<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/nsc\/20338.html\/#%E6%88%90%E5%B9%B4%E5%A4%A7%E8%84%91%E4%B8%AD%E7%9A%84%E7%A5%9E%E7%BB%8F%E5%B9%B2%E7%BB%86%E8%83%9E\" >\u6210\u5e74\u5927\u8111\u4e2d\u7684\u795e\u7ecf\u5e72\u7ec6\u80de<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/nsc\/20338.html\/#%E5%A4%9A%E8%83%BD%E5%B9%B2%E7%BB%86%E8%83%9E%EF%BC%9A%E8%A1%8D%E7%94%9F%E7%9A%84%E7%A5%9E%E7%BB%8F%E5%B9%B2%E7%BB%86%E8%83%9E\" >\u591a\u80fd\u5e72\u7ec6\u80de\uff1a\u884d\u751f\u7684\u795e\u7ecf\u5e72\u7ec6\u80de<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/nsc\/20338.html\/#%E6%B2%BB%E7%96%97%E5%89%8D%E6%99%AF%E4%B8%8E%E6%9B%BF%E4%BB%A3%E7%AD%96%E7%95%A5\" >\u6cbb\u7597\u524d\u666f\u4e0e\u66ff\u4ee3\u7b56\u7565<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/nsc\/20338.html\/#%E6%80%BB%E7%BB%93%E4%B8%8E%E5%B1%95%E6%9C%9B\" >Summary and outlook<\/a><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"%E5%B9%B2%E7%BB%86%E8%83%9E%EF%BC%9A%E7%94%9F%E5%91%BD%E7%9A%84%E7%A7%8D%E5%AD%90\"><\/span><strong>\u5e72\u7ec6\u80de\uff1a\u751f\u547d\u7684\u79cd\u5b50<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p class=\"ds-markdown-paragraph\">\u201c\u5e72\u7ec6\u80de\u201d\u4e00\u8bcd\u6700\u65e9\u4e8e1868\u5e74\u51fa\u73b0\u5728\u79d1\u5b66\u6587\u732e\u4e2d\uff0c\u7531\u5fb7\u56fd\u751f\u7269\u5b66\u5bb6\u6069\u65af\u7279\u00b7\u6d77\u514b\u5c14\u63d0\u51fa\u3002\u8be5\u672f\u8bed\u6700\u521d\u6709\u4e24\u79cd\u542b\u4e49\uff1a\u4e00\u662f\u6240\u6709\u591a\u7ec6\u80de\u751f\u7269\u7684\u5355\u7ec6\u80de\u8fdb\u5316\u8d77\u6e90\uff0c\u4e8c\u662f\u6307\u80fd\u5206\u5316\u5f62\u6210\u4f53\u5185\u6240\u6709\u7ec6\u80de\u7c7b\u578b\u7684\u53d7\u7cbe\u5375\u3002\u540e\u8005\u9010\u6e10\u6f14\u53d8\u4e3a\u73b0\u4ee3\u5b9a\u4e49\u2014\u2014<strong>\u80fd\u591f\u81ea\u6211\u66f4\u65b0\u5e76\u5206\u5316\u6210\u591a\u79cd\u7279\u5b9a\u7ec6\u80de\u7c7b\u578b\u7684\u7ec6\u80de<\/strong>The<\/p>\n<p class=\"ds-markdown-paragraph\">\u5e72\u7ec6\u80de\u7684\u884c\u4e3a\u4e0e\u547d\u8fd0\u6df1\u53d7\u5176\u6240\u5728\u7684\u7279\u5b9a\u89e3\u5256\u4f4d\u7f6e\uff0c\u5373\u201c<strong>\u5e72\u7ec6\u80de\u5fae\u73af\u5883<\/strong>\u201d\u7684\u5f71\u54cd\u3002\u8fd9\u4e2a\u5fae\u73af\u5883\u4e0d\u4ec5\u63d0\u4f9b\u7269\u7406\u652f\u6491\uff0c\u8fd8\u5206\u6ccc\u5404\u79cd\u56e0\u5b50\u6765\u7ef4\u6301\u548c\u8c03\u63a7\u5e72\u7ec6\u80de\u7684\u72b6\u6001\u3002\u540c\u65f6\uff0c\u5e72\u7ec6\u80de\u4e5f\u53d7\u5230\u590d\u6742\u7684<strong>\u5185\u5728\u4fe1\u53f7\u901a\u8def\u4e0e\u8f6c\u5f55\u673a\u5236<\/strong>\u7684\u8c03\u63a7\uff0c\u5176\u4e2d\u90e8\u5206\u4e3a\u5404\u7c7b\u5e72\u7ec6\u80de\u6240\u5171\u6709\uff0c\u90e8\u5206\u5219\u4e3a\u7279\u5b9a\u7c7b\u578b\u6240\u7279\u6709\u3002\u8457\u540d\u7684\u8c03\u63a7\u56e0\u5b50\u5305\u62ecTGF-\u03b2\u3001BMP\u3001Wnt\u3001Notch\u7b49\u3002\u6b63\u662f\u5728\u8fd9\u79cd\u5185\u5916\u56e0\u7d20\u7684\u7cbe\u5bc6\u534f\u4f5c\u4e0b\uff0c\u5e72\u7ec6\u80de\u5f97\u4ee5\u5728\u65f6\u95f4\u4e0e\u7a7a\u95f4\u4e0a\u88ab\u7cbe\u51c6\u8c03\u63a7\uff0c\u7ef4\u6301\u5176\u72ec\u7279\u6027\u8d28\u3002\u7406\u89e3\u8fd9\u4e9b\u673a\u5236\uff0c\u4e3a\u6211\u4eec\u63a2\u7d22\u53d1\u80b2\u5965\u79d8\u53ca\u76f8\u5173\u75be\u75c5\u5f00\u542f\u4e86\u5927\u95e8\u3002<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%E7%A5%9E%E7%BB%8F%E5%B9%B2%E7%BB%86%E8%83%9E%E7%9A%84%E5%8F%91%E8%82%B2%E6%9C%BA%E5%88%B6%EF%BC%9A%E5%8F%91%E8%82%B2%E4%B8%AD%E7%9A%84%E8%BF%87%E7%A8%8B\"><\/span><strong>\u795e\u7ecf\u5e72\u7ec6\u80de\u7684\u53d1\u80b2\u673a\u5236\uff1a\u53d1\u80b2\u4e2d\u7684\u8fc7\u7a0b<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p class=\"ds-markdown-paragraph\">\u5728\u53d1\u80b2\u4f0a\u59cb\uff0c\u6574\u4e2a\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u8d77\u6e90\u4e8e\u795e\u7ecf\u7ba1\u5185\u58c1\u7684\u5c11\u91cf\u795e\u7ecf\u5e72\u7ec6\u80de\u3002\u5b83\u4eec\u901a\u8fc7\u7cbe\u786e\u7684\u5206\u88c2\u6a21\u5f0f\uff0c\u6784\u5efa\u51fa\u590d\u6742\u7684\u5927\u8111\u7ed3\u6784\u3002\u5728\u54fa\u4e73\u52a8\u7269\u4e2d\uff0c\u8fd9\u4e9b\u7ec6\u80de\u7279\u5316\u4e3a<strong>\u653e\u5c04\u72b6\u80f6\u8d28\u7ec6\u80de<\/strong>\uff0c\u5b83\u4eec\u9996\u5148\u901a\u8fc7<strong>\u5bf9\u79f0\u5206\u88c2<\/strong>\u8fdb\u884c\u81ea\u6211\u6269\u589e\uff0c\u58ee\u5927\u5e72\u7ec6\u80de\u5e93\uff1b\u968f\u540e\u901a\u8fc7<strong>\u4e0d\u5bf9\u79f0\u5206\u88c2<\/strong>\uff0c\u4ea7\u751f<strong>\u4e2d\u95f4\u7956\u7ec6\u80de<\/strong>\u53ca\u5404\u7c7b\u5206\u5316\u7ec6\u80de\u3002\u6574\u4e2a\u8fc7\u7a0b\u9075\u5faa\u4e25\u683c\u7684\u65f6\u95f4\u987a\u5e8f\uff1a<strong>\u795e\u7ecf\u5143<\/strong>\u6700\u5148\u88ab\u751f\u6210\uff0c\u4ee5\u642d\u5efa\u57fa\u7840\u795e\u7ecf\u56de\u8def\uff1b\u968f\u540e\u662f\u63d0\u4f9b\u652f\u6301\u4e0e\u8425\u517b\u7684<strong>\u661f\u5f62\u80f6\u8d28\u7ec6\u80de<\/strong>\uff1b\u6700\u540e\u624d\u662f\u8d1f\u8d23\u7edd\u7f18\u5e76\u52a0\u901f\u795e\u7ecf\u4fe1\u53f7\u4f20\u5bfc\u7684<strong>\u5c11\u7a81\u80f6\u8d28\u7ec6\u80de<\/strong>The<\/p>\n<p class=\"ds-markdown-paragraph\">\u8fd1\u5e74\u6765\uff0c\u6280\u672f\u7684\u8fdb\u6b65\u63ed\u793a\u4e86\u4eba\u7c7b\u7279\u6709\u7684\u795e\u7ecf\u5e72\u7ec6\u80de\u7fa4\uff0c\u4f8b\u5982\u4f4d\u4e8e\u5916\u4fa7\u5ba4\u4e0b\u533a\u7684<strong>\u5916\u4fa7\u653e\u5c04\u72b6\u80f6\u8d28\u7ec6\u80de<\/strong>\u3002\u8fd9\u7c7b\u7ec6\u80de\u7684\u6d3b\u8dc3\u589e\u6b96\u88ab\u8ba4\u4e3a\u662f<strong>\u4eba\u7c7b\u5927\u8111\u76ae\u5c42\u4f53\u79ef\u5de8\u5927\u3001\u7ed3\u6784\u590d\u6742<\/strong>\u7684\u5173\u952e\u3002\u5bf9\u8fd9\u4e9b\u7ec6\u80de\u53ca\u5176\u7279\u5f02\u6027\u6807\u5fd7\u7269\u7684\u6df1\u5165\u7814\u7a76\uff0c\u4e0d\u4ec5\u6df1\u5316\u4e86\u6211\u4eec\u5bf9\u5927\u8111\u53d1\u80b2\u548c\u76f8\u5173\u75be\u75c5\u7684\u8ba4\u8bc6\uff0c\u66f4\u76f4\u63a5\u63a8\u52a8\u4e86\u518d\u751f\u533b\u5b66\u7684\u8fdb\u6b65\uff0c\u6307\u5bfc\u79d1\u5b66\u5bb6\u4f18\u5316\u4ece\u591a\u80fd\u5e72\u7ec6\u80de\u5b9a\u5411\u8bf1\u5bfc\u7279\u5b9a\u795e\u7ecf\u7ec6\u80de\u7684\u65b9\u6848\uff0c\u4e3a\u75be\u75c5\u5efa\u6a21\u4e0e\u7ec6\u80de\u6cbb\u7597\u5960\u5b9a\u4e86\u575a\u5b9e\u57fa\u7840\u3002<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%E6%88%90%E5%B9%B4%E5%A4%A7%E8%84%91%E4%B8%AD%E7%9A%84%E7%A5%9E%E7%BB%8F%E5%B9%B2%E7%BB%86%E8%83%9E\"><\/span><strong>\u6210\u5e74\u5927\u8111\u4e2d\u7684\u795e\u7ecf\u5e72\u7ec6\u80de<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p class=\"ds-markdown-paragraph\">\u5728\u6210\u5e74\u5927\u8111\u4e2d\uff0c\u795e\u7ecf\u5e72\u7ec6\u80de\u5e76\u672a\u5b8c\u5168\u6d88\u5931\uff0c\u800c\u662f\u6f5c\u85cf\u5728<strong>\u6d77\u9a6c\u4f53<\/strong>respond in singing<strong>\u4fa7\u8111\u5ba4\u4e0b\u533a<\/strong>\u7b49\u7279\u5b9a\u7684\u201c\u5fae\u73af\u5883\u201d\u4e2d\u3002\u8fd9\u4e00\u53d1\u73b0\u63a8\u7ffb\u4e86\u201c\u6210\u4eba\u5927\u8111\u4e0d\u518d\u4ea7\u751f\u65b0\u795e\u7ecf\u5143\u201d\u7684\u9648\u65e7\u6559\u6761\uff0c\u662f\u795e\u7ecf\u79d1\u5b66\u9886\u57df\u7684\u91cd\u5927\u7a81\u7834\u3002\u8fd9\u4e9b\u533a\u57df\u7684\u795e\u7ecf\u5e72\u7ec6\u80de\u6301\u7eed\u8fdb\u884c\u201c<strong>\u6210\u5e74\u795e\u7ecf\u53d1\u751f<\/strong>\u201d\uff0c\u5373\u7ec8\u8eab\u4ea7\u751f\u65b0\u7684\u795e\u7ecf\u5143\u3002\u5176\u4e2d\uff0c\u6d77\u9a6c\u533a\u7684\u65b0\u751f\u795e\u7ecf\u5143\u5bf9<strong>\u5b66\u4e60\u3001\u8bb0\u5fc6\u5f62\u6210<\/strong>\uff08\u7279\u522b\u662f\u6a21\u5f0f\u5206\u79bb\u548c\u7a7a\u95f4\u5b66\u4e60\uff09\u81f3\u5173\u91cd\u8981\uff0c\u800c\u4fa7\u8111\u5ba4\u4e0b\u533a\u7684\u795e\u7ecf\u53d1\u751f\u5219\u4e3b\u8981\u8d21\u732e\u4e8e<strong>\u55c5\u89c9\u529f\u80fd<\/strong>The<\/p>\n<p class=\"ds-markdown-paragraph\">\u6210\u5e74\u795e\u7ecf\u5e72\u7ec6\u80de\u7684\u6d3b\u52a8\u53d7\u5230\u4e00\u4e2a\u590d\u6742\u7f51\u7edc\u7684\u7cbe\u5bc6\u8c03\u63a7\u3002\u8fd9\u4e2a\u7f51\u7edc\u65e2\u5305\u62ec<strong>\u8f6c\u5f55\u56e0\u5b50\uff08\u5982Sox2\uff09\u3001\u8868\u89c2\u9057\u4f20\u8c03\u63a7<\/strong>\u7b49\u5185\u6e90\u6027\u673a\u5236\uff0c\u4e5f\u53d7\u5230<strong>\u751f\u7406\u6d3b\u52a8\u3001\u73af\u5883\u523a\u6fc0\u3001\u538b\u529b\u53ca\u75be\u75c5\uff08\u5982\u766b\u75eb\u3001\u4e2d\u98ce\u3001\u6291\u90c1\u75c7\uff09<\/strong>\u00a0\u7b49\u5916\u6e90\u6027\u56e0\u7d20\u7684\u663e\u8457\u5f71\u54cd\u3002\u5728\u6240\u6709\u8fd9\u4e9b\u56e0\u7d20\u4e2d\uff0c<strong>\u8870\u8001\u662f\u6210\u5e74\u795e\u7ecf\u53d1\u751f\u6700\u5f3a\u6709\u529b\u7684\u8d1f\u5411\u8c03\u8282\u56e0\u5b50<\/strong>\uff0c\u5b83\u4e0e\u591a\u79cd\u5185\u5728\u548c\u5916\u5728\u673a\u5236\u5171\u540c\u5bfc\u81f4\u4e86\u795e\u7ecf\u5e72\u7ec6\u80de\u6d3b\u6027\u968f\u5e74\u9f84\u589e\u957f\u800c\u9010\u6e10\u8870\u9000\u3002<\/p>\n<p class=\"ds-markdown-paragraph\">\u5c3d\u7ba1\u7814\u7a76\u5df2\u53d6\u5f97\u957f\u8db3\u8fdb\u5c55\uff0c\u4f46\u8be5\u9886\u57df\u4ecd\u9762\u4e34\u6838\u5fc3\u6311\u6218\uff1a\u65b0\u751f\u795e\u7ecf\u5143\u662f\u5982\u4f55\u7cbe\u786e\u6574\u5408\u5230\u73b0\u6709\u8111\u56de\u8def\u4e2d\u5e76\u53d1\u6325\u529f\u80fd\u7684\uff1f\u5176\u5177\u4f53\u673a\u5236\u4ecd\u662f\u4e00\u4e2a\u5f85\u89e3\u7684\u8c1c\u9898\u3002\u7834\u89e3\u8fd9\u4e00\u8c1c\u9898\uff0c\u4e0d\u4ec5\u80fd\u9610\u660e\u795e\u7ecf\u5e72\u7ec6\u80de\u5728\u5927\u8111\u5065\u5eb7\u4e0e\u75be\u75c5\u4e2d\u7684\u4f5c\u7528\uff0c\u66f4\u5c06\u4e3a\u5f00\u53d1\u9488\u5bf9\u795e\u7ecf\u635f\u4f24\u4e0e\u9000\u884c\u6027\u75be\u75c5\u7684\u521b\u65b0\u6cbb\u7597\u7b56\u7565\u63d0\u4f9b\u5173\u952e\u7ebf\u7d22\u3002<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%E5%A4%9A%E8%83%BD%E5%B9%B2%E7%BB%86%E8%83%9E%EF%BC%9A%E8%A1%8D%E7%94%9F%E7%9A%84%E7%A5%9E%E7%BB%8F%E5%B9%B2%E7%BB%86%E8%83%9E\"><\/span><strong>\u591a\u80fd\u5e72\u7ec6\u80de\uff1a\u884d\u751f\u7684\u795e\u7ecf\u5e72\u7ec6\u80de<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p class=\"ds-markdown-paragraph\">\u7531\u4e8e\u76f4\u63a5\u83b7\u53d6\u4eba\u8111\u795e\u7ecf\u5e72\u7ec6\u80de\u6781\u4e3a\u56f0\u96be\uff0c<strong>\u4eba\u7c7b\u591a\u80fd\u5e72\u7ec6\u80de<\/strong>\uff0c\u5305\u62ec\u80da\u80ce\u5e72\u7ec6\u80de\u548c\u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de\uff0c\u6210\u4e3a\u4e86\u7814\u7a76\u4eba\u7c7b\u795e\u7ecf\u53d1\u80b2\u4e0e\u75be\u75c5\u7684\u7406\u60f3\u201c\u4f53\u5916\u6a21\u578b\u201d\u3002\u5176\u4e2d\uff0c<strong>\u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de\u6280\u672f<\/strong>\u5c24\u5176\u5173\u952e\uff0c\u5b83\u80fd\u591f\u5c06\u60a3\u8005\u81ea\u8eab\u7684\u4f53\u7ec6\u80de\uff08\u5982\u76ae\u80a4\u7ec6\u80de\uff09\u91cd\u7f16\u7a0b\u4e3a\u5177\u6709\u591a\u80fd\u6027\u7684\u5e72\u7ec6\u80de\uff0c\u4f7f\u79d1\u5b66\u5bb6\u80fd\u5927\u89c4\u6a21\u83b7\u5f97\u643a\u5e26\u7279\u5b9a\u75be\u75c5\u57fa\u56e0\u7684\u795e\u7ecf\u7ec6\u80de\uff0c\u5f7b\u5e95\u6539\u53d8\u4e86\u6211\u4eec\u7814\u7a76\u4eba\u7c7b\u72ec\u6709\u75be\u75c5\u7684\u80fd\u529b\u3002<\/p>\n<p class=\"ds-markdown-paragraph\">\u5c06\u591a\u80fd\u5e72\u7ec6\u80de\u8f6c\u5316\u4e3a\u795e\u7ecf\u7ec6\u80de\u7684\u7b2c\u4e00\u6b65\u662f\u201c<strong>\u795e\u7ecf\u8bf1\u5bfc<\/strong>\u201d\u3002\u901a\u8fc7\u7cbe\u786e\u8c03\u63a7\u7ec6\u80de\u4fe1\u53f7\u901a\u8def\uff0c\u6a21\u62df\u80da\u80ce\u53d1\u80b2\u8fc7\u7a0b\uff0c\u4f7f\u5176\u9010\u6b65\u5206\u5316\u4e3a\u795e\u7ecf\u4e0a\u76ae\u6837\u7ec6\u80de\u3001\u795e\u7ecf\u5e72\u7ec6\u80de\u53ca\u4e2d\u95f4\u795e\u7ecf\u7956\u7ec6\u80de\u3002\u7136\u800c\uff0c\u8be5\u8fc7\u7a0b\u9762\u4e34\u7684\u4e3b\u8981\u6311\u6218\u5728\u4e8e\u5982\u4f55<strong>\u7cbe\u786e\u63a7\u5236\u7ec6\u80de\u8c31\u7cfb<\/strong>\uff0c\u4ee5\u5b9e\u73b0\u9ad8\u7eaf\u5ea6\u3001\u7279\u5b9a\u7c7b\u578b\u795e\u7ecf\u5143\uff08\u5982\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u3001GABA\u80fd\u795e\u7ecf\u5143\u7b49\uff09\u7684\u751f\u4ea7\u3002\u76ee\u524d\u5206\u5316\u6240\u5f97\u7684\u7ec6\u80de\u7fa4\u4f53\u4ecd\u5b58\u5728\u663e\u8457\u7684\u5f02\u8d28\u6027\uff0c\u800c\u5229\u7528<strong>\u5355\u7ec6\u80de\u5206\u6790\u6280\u672f<\/strong>\u6b63\u6709\u52a9\u4e8e\u66f4\u7cbe\u7ec6\u5730\u89e3\u6790\u548c\u4f18\u5316\u8fd9\u4e00\u590d\u6742\u8fc7\u7a0b\u3002<\/p>\n<p class=\"ds-markdown-paragraph\">\u7ed3\u5408iPSC\u4e0e<strong>\u57fa\u56e0\u7f16\u8f91\u6280\u672f<\/strong>\uff0c\u79d1\u5b66\u5bb6\u80fd\u591f\u5728\u57f9\u517b\u76bf\u4e2d\u521b\u5efa\u9ad8\u5ea6\u6a21\u62df\u4eba\u7c7b\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u7684\u6a21\u578b\u3002\u8fd9\u5bf9\u4e8e\u7814\u7a76\u8bb8\u591a\u5c0f\u9f20\u6a21\u578b\u65e0\u6cd5\u5145\u5206\u6a21\u62df\u7684\u4eba\u7c7b\u7279\u6709\u75be\u75c5\uff08\u5982\u8106\u6027X\u7efc\u5408\u5f81\uff09\u81f3\u5173\u91cd\u8981\u3002\u901a\u8fc7\u5c06\u60a3\u8005\u6765\u6e90\u7684iPSCs\u5206\u5316\u4e3a\u795e\u7ecf\u5e72\u7ec6\u80de\u548c\u795e\u7ecf\u5143\uff0c\u6211\u4eec\u53ef\u4ee5\u5728\u4f53\u5916\u6df1\u5165\u63ed\u793a\u75be\u75c5\u673a\u5236\u3001\u7b5b\u9009\u6709\u6548\u836f\u7269\uff0c\u4e3a\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u7684<strong>\u7cbe\u51c6\u533b\u7597<\/strong>\u5f00\u8f9f\u5168\u65b0\u7684\u9053\u8def\u3002<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%E6%B2%BB%E7%96%97%E5%89%8D%E6%99%AF%E4%B8%8E%E6%9B%BF%E4%BB%A3%E7%AD%96%E7%95%A5\"><\/span><strong>\u6cbb\u7597\u524d\u666f\u4e0e\u66ff\u4ee3\u7b56\u7565<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p class=\"ds-markdown-paragraph\">\u795e\u7ecf\u5e72\u7ec6\u80de\u4f5c\u4e3a\u6cbb\u7597\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u548c\u635f\u4f24\u7684\u7b56\u7565\u5df2\u88ab\u63a2\u7d22\u6570\u5341\u5e74\u3002\u5176\u4e2d\uff0c<a href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/nsc\/19266.html\/\" target=\"_blank\" rel=\"noopener\"><strong>Parkinson's disease<\/strong><\/a>\u56e0\u6d89\u53ca\u660e\u786e\u7684\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u7f3a\u5931\u800c\u5907\u53d7\u5173\u6ce8\uff1b\u6b64\u5916\uff0c\u5728\u4ea8\u5ef7\u987f\u75c5\u3001\u4e2d\u98ce\u548c\u810a\u9ad3\u635f\u4f24\u6a21\u578b\u4e2d\uff0c\u795e\u7ecf\u5e72\u7ec6\u80de\u4e5f\u5c55\u73b0\u51fa\u6f5c\u529b\u3002\u5728\u67d0\u4e9b\u60c5\u51b5\u4e0b\uff0c\u79fb\u690d\u7684\u795e\u7ecf\u5e72\u7ec6\u80de\u80fd\u5728\u5c40\u90e8\u5fae\u73af\u5883\u4e2d\u5206\u5316\u4e3a\u6240\u9700\u7684\u7ec6\u80de\u7c7b\u578b\uff1b\u800c\u5728\u5176\u4ed6\u60c5\u51b5\u4e0b\uff0c\u5b83\u4eec\u5219\u4e3b\u8981\u901a\u8fc7\u5206\u6ccc\u8425\u517b\u56e0\u5b50\u7b49<strong>\u652f\u6301\u6027\u4f5c\u7528<\/strong>\u6765\u4fc3\u8fdb\u4fee\u590d\u3002<\/p>\n<p class=\"ds-markdown-paragraph\">\u5c3d\u7ba1\u57fa\u4e8e\u591a\u80fd\u5e72\u7ec6\u80de\u7684\u6280\u672f\u662f\u672a\u6765\u7684\u65b9\u5411\uff0c\u4f46\u5176\u5e94\u7528\u4ecd\u5b58\u5728\u5c40\u9650\u6027\u548c\u98ce\u9669\u3002\u65e0\u8bba\u662f\u80da\u80ce\u5e72\u7ec6\u80de\u3001\u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de\u8fd8\u662f\u5176\u5206\u5316\u7684\u795e\u7ecf\u5e72\u7ec6\u80de\uff0c\u5747\u4e3a\u5206\u88c2\u7ec6\u80de\uff0c\u79fb\u690d\u5165\u4f53\u5185\u5b58\u5728<strong>\u80bf\u7624\u5f62\u6210\u7684\u98ce\u9669<\/strong>\u3002\u6b64\u5916\uff0c\u4f53\u7ec6\u80de\u91cd\u7f16\u7a0b\u4e3aiPSC\u7684\u8fc7\u7a0b\u4f1a\u62b9\u53bb\u4e00\u4e9b\u4e0e\u75be\u75c5\u548c\u8870\u8001\u76f8\u5173\u7684\u8868\u89c2\u9057\u4f20\u7279\u5f81\uff0c\u8fd9\u53ef\u80fd\u5f71\u54cd\u75be\u75c5\u5efa\u6a21\u7684\u51c6\u786e\u6027\u3002<\/p>\n<p class=\"ds-markdown-paragraph\">\u56e0\u6b64\uff0c\u79d1\u5b66\u5bb6\u4eec\u5f00\u59cb\u63a2\u7d22\u80fd\u5426\u201c<strong>\u7ed5\u8fc7<\/strong>\u201d\u795e\u7ecf\u5e72\u7ec6\u80de\u9636\u6bb5\u3002<strong>\u76f4\u63a5\u91cd\u7f16\u7a0b<\/strong>\u6280\u672f\u53ef\u5c06\u6210\u7ea4\u7ef4\u7ec6\u80de\u7b49\u5176\u4ed6\u4f53\u7ec6\u80de\u76f4\u63a5\u8f6c\u5316\u4e3a\u8bf1\u5bfc\u795e\u7ecf\u5143\u3002\u8d8a\u6765\u8d8a\u591a\u7684\u7814\u7a76\u8868\u660e\uff0c\u8fd9\u79cd\u65b9\u6cd5\u5728\u4f53\u5185\u5916\u5747\u6709\u6548\u3002\u8df3\u8fc7\u795e\u7ecf\u5e72\u7ec6\u80de\u9636\u6bb5\u5404\u6709\u4f18\u52a3\uff1a\u5b83\u964d\u4f4e\u4e86\u80bf\u7624\u98ce\u9669\u5e76\u53ef\u80fd\u66f4\u5feb\u5730\u83b7\u5f97\u529f\u80fd\u795e\u7ecf\u5143\uff0c\u4f46\u4e5f\u53ef\u80fd\u56e0\u6b64\u4e27\u5931\u4e86\u5e72\u7ec6\u80de\u56fa\u6709\u7684\u6269\u589e\u80fd\u529b\u548c\u591a\u5411\u5206\u5316\u6f5c\u80fd\u3002\u8fd9\u6761\u5168\u65b0\u7684\u8c31\u7cfb\u5b9a\u5411\u9014\u5f84\uff0c\u4e3a\u7ec6\u80de\u6cbb\u7597\u5e26\u6765\u4e86\u66f4\u591a\u6837\u7684\u9009\u62e9\u3002<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%E6%80%BB%E7%BB%93%E4%B8%8E%E5%B1%95%E6%9C%9B\"><\/span><strong>Summary and outlook<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p class=\"ds-markdown-paragraph\">\u795e\u7ecf\u5e72\u7ec6\u80de\u56e0\u5176\u5f3a\u5927\u7684\u529f\u80fd\u3001\u5353\u8d8a\u7684\u9002\u5e94\u6027\u4e0e\u591a\u6837\u6027\u800c\u6210\u4e3a\u6781\u5177\u9b45\u529b\u7684\u7ec6\u80de\u7c7b\u578b\u3002\u7406\u89e3\u5b83\u4eec\u7684\u529f\u80fd\uff0c\u5bf9\u4e8e\u63ed\u793a\u795e\u7ecf\u7cfb\u7edf\u7684\u53d1\u80b2\u3001\u9002\u5e94\u3001\u75be\u75c5\u3001\u518d\u751f\u4e0e\u5eb7\u590d\u673a\u5236\u81f3\u5173\u91cd\u8981\u3002\u5229\u7528\u556e\u9f7f\u52a8\u7269\u6a21\u578b\u5bf9\u5927\u8111\u53d1\u80b2\u548c\u6210\u5e74\u795e\u7ecf\u53d1\u751f\u7684\u7814\u7a76\uff0c\u5df2\u6781\u5927\u5730\u589e\u8fdb\u4e86\u6211\u4eec\u7684\u8ba4\u77e5\uff0c\u800c\u65b0\u578b\u57fa\u56e0\u4e0e\u6210\u50cf\u6280\u672f\u7684\u8fdb\u6b65\uff0c\u5c06\u6301\u7eed\u63a8\u52a8\u8fd9\u4e00\u9886\u57df\u5411\u524d\u53d1\u5c55\u3002<\/p>\n<p class=\"ds-markdown-paragraph\">\u66f4\u91cd\u8981\u7684\u662f\uff0c\u5229\u7528\u4eba\u7c7b\u795e\u7ecf\u5e72\u7ec6\u80de\u4e3a\u6211\u4eec\u63d0\u4f9b\u4e86\u4e00\u4e2a\u72ec\u4e00\u65e0\u4e8c\u7684\u7a97\u53e3\uff0c\u4ee5\u63a2\u7a76\u4eba\u7c7b\u7279\u6709\u7684\u53d1\u80b2\u7a0b\u5e8f\u548c\u75be\u75c5\u673a\u5236\u3002\u5e72\u7ec6\u80de\u4e0e\u57fa\u56e0\u7f16\u8f91\u6280\u672f\u7684\u98de\u901f\u53d1\u5c55\uff0c\u6b63\u4e0d\u65ad\u589e\u5f3a\u6211\u4eec\u900f\u8fc7\u8fd9\u4e2a\u7a97\u53e3\u89c2\u5bdf\u7ec6\u8282\u7684\u80fd\u529b\u3002\u5f53\u524d\uff0c\u6211\u4eec\u5728\u7ec6\u80de\u8c31\u7cfb\u63a7\u5236\u3001\u4f53\u5185\u795e\u7ecf\u5e72\u7ec6\u80de\u884c\u4e3a\u3001\u4e09\u7ef4\u7ec6\u80de\u76f8\u4e92\u4f5c\u7528\u4ee5\u53ca\u8868\u89c2\u9057\u4f20\u8bb0\u5fc6\u7684\u4fdd\u5b58\u7b49\u65b9\u9762\u4ecd\u9762\u4e34\u6311\u6218\u3002\u514b\u670d\u8fd9\u4e9b\u6311\u6218\uff0c\u5c06\u6700\u7ec8\u63a8\u52a8\u4eba\u7c7b\u795e\u7ecf\u75be\u75c5\u7684\u5efa\u6a21\u4e0e\u6cbb\u7597\u4ece\u5b9e\u9a8c\u5ba4\u8d70\u5411\u4e34\u5e8a\uff0c\u4e3a\u65e0\u6570\u60a3\u8005\u5e26\u6765\u65b0\u7684\u5e0c\u671b\u3002<\/p>\n<\/section>","protected":false},"excerpt":{"rendered":"<p>\u8fc7\u53bb\u56db\u5341\u5e74\u6765\uff0c\u5e72\u7ec6\u80de\u751f\u7269\u5b66\u53d6\u5f97\u4e86\u60ca\u4eba\u8fdb\u5c55\uff0c\u5f7b\u5e95\u6539\u53d8\u4e86\u79d1\u5b66\u4e0e\u533b\u5b66\u7684\u9762\u8c8c\u3002\u4f5c\u4e3a\u795e\u7ecf\u7cfb\u7edf\u7684\u5960\u57fa\u8005\uff0c\u795e\u7ecf\u5e72\u7ec6\u80de\u5728\u53d1\u80b2\u8fc7 [&hellip;]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[73],"tags":[165],"_links":{"self":[{"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/posts\/20338"}],"collection":[{"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/comments?post=20338"}],"version-history":[{"count":1,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/posts\/20338\/revisions"}],"predecessor-version":[{"id":20340,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/posts\/20338\/revisions\/20340"}],"wp:attachment":[{"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/media?parent=20338"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/categories?post=20338"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/tags?post=20338"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}