{"id":20370,"date":"2025-11-11T16:55:25","date_gmt":"2025-11-11T08:55:25","guid":{"rendered":"https:\/\/www.hjtdsm.cn\/?p=20370"},"modified":"2025-11-11T16:55:25","modified_gmt":"2025-11-11T08:55:25","slug":"%e6%b2%bb%e7%96%97%e5%b8%95%e9%87%91%e6%a3%ae%e7%97%85%e7%9a%84%e6%96%b9%e6%b3%95","status":"publish","type":"post","link":"https:\/\/www.hjtdsm.cn\/en\/research\/ns\/pd\/20370.html","title":{"rendered":"\u6b63\u5728\u5f00\u53d1\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\u7684\u65b9\u6cd5\uff1a\u5e72\u7ec6\u80de\u3001\u57fa\u56e0\u7597\u6cd5\u4e0e\u65b0\u836f\u5982\u4f55\u91cd\u5851\u672a\u6765"},"content":{"rendered":"<section data-role=\"list\">\n<section data-role=\"list\" data-pm-slice=\"4 4 [&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;outer&quot;,&quot;label&quot;:&quot;edit by 135editor&quot;,&quot;data-pm-slice&quot;:&quot;0 0 []&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;paragraph&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;}]\"><a href=\"https:\/\/www.hjtdsm.cn\/en\/research\/ns\/pd\/19756.html\/\" target=\"_blank\" rel=\"noopener\">Parkinson's disease<\/a>\u662f\u4e00\u79cd\u4f1a\u5f71\u54cd\u8fd0\u52a8\u529f\u80fd\u7684\u75be\u75c5\uff0c\u5f71\u54cd\u7740\u5168\u7403\u7ea61000\u4e07\u4eba\u3002\u76ee\u524d\uff0c\u5e15\u91d1\u68ee\u75c5\u7684\u6cbb\u7597\u65b9\u6cd5\u53ef\u4ee5\u5e2e\u52a9\u63a7\u5236\u75c7\u72b6\uff0c\u4f46\u5c1a\u672a\u6cbb\u6108\u3002\u5de6\u65cb\u591a\u5df4\u4f5c\u4e3a\u9996\u4e2a\u771f\u6b63\u6709\u6548\u7684\u6cbb\u7597\u836f\u7269\uff0c\u56e0\u5176\u6bd2\u526f\u4f5c\u7528\u800c\u5907\u53d7\u4e89\u8bae\uff0c\u4f46\u5b83\u4ecd\u7136\u662f\u5e15\u91d1\u68ee\u75c5\u6cbb\u7597\u7684\u9ec4\u91d1\u6807\u51c6\u3002<\/p>\n<section><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-20375 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/istockphoto-491174118-612x612-1.jpg\" alt=\"\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\u7684\u65b9\u6cd5\" width=\"612\" height=\"388\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/istockphoto-491174118-612x612-1.jpg 612w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/istockphoto-491174118-612x612-1-300x190.jpg 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/istockphoto-491174118-612x612-1-18x12.jpg 18w\" sizes=\"(max-width: 612px) 100vw, 612px\" \/><\/p>\n<\/section>\n<p>\u7136\u800c\uff0c\u8fd1\u6765\uff0c\u6b63\u5728\u5f00\u53d1\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\u7684\u65b9\u6cd5\uff0c\u6709\u671b\u53d6\u4ee3\u5de6\u65cb\u591a\u5df4\u5728\u5e15\u91d1\u68ee\u75c5\u6cbb\u7597\u4e2d\u7684\u5730\u4f4d\u3002\u9664\u4e86\u5c0f\u5206\u5b50\u836f\u7269\u3001\u57fa\u56e0\u7597\u6cd5\u3001\u6297\u4f53\u836f\u7269\u7b49\u7b56\u7565\u5916\uff0c\u5e72\u7ec6\u80de\u6cbb\u7597\u4e5f\u4f5c\u4e3a\u518d\u751f\u533b\u5b66\u7684\u4ee3\u8868\uff0c\u4e3a\u75be\u75c5\u4fee\u9970\u5e26\u6765\u4e86\u65b0\u7684\u53ef\u80fd\u3002\u4e00\u79cd\u65b0\u7684\u5e15\u91d1\u68ee\u75c5\u836f\u7269\u5373\u5c06\u83b7\u6279\uff0c\u4f46\u5b83\u5c06\u5982\u4f55\u6539\u5584\u60a3\u8005\u7684\u751f\u6d3b\u5462\uff1f<\/p>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_79_2 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewbox=\"0 0 24 24\" version=\"1.2\" baseprofile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 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href=\"https:\/\/www.hjtdsm.cn\/en\/research\/ns\/pd\/20370.html\/#%E7%9B%AE%E5%BD%95\" >\u76ee\u5f55<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.hjtdsm.cn\/en\/research\/ns\/pd\/20370.html\/#01%E3%80%81%E5%A4%9A%E5%B7%B4%E8%83%BA%E7%BC%BA%E4%B9%8F%EF%BC%9A%E5%B8%95%E9%87%91%E6%A3%AE%E7%97%85%E5%A6%82%E4%BD%95%E5%BD%B1%E5%93%8D%E8%BA%AB%E4%BD%93%EF%BC%9F\" >01\u3001\u591a\u5df4\u80fa\u7f3a\u4e4f\uff1a\u5e15\u91d1\u68ee\u75c5\u5982\u4f55\u5f71\u54cd\u8eab\u4f53\uff1f<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/www.hjtdsm.cn\/en\/research\/ns\/pd\/20370.html\/#02%E3%80%81%E5%B8%95%E9%87%91%E6%A3%AE%E7%97%85%E6%B2%BB%E7%96%97%E4%B8%AD%EF%BC%8CTavapadon%E4%B8%8E%E5%B7%A6%E6%97%8B%E5%A4%9A%E5%B7%B4%E7%9A%84%E6%AF%94%E8%BE%83%EF%BC%9A%E8%89%BE%E4%BC%AF%E7%BB%B4%E7%9A%84%E8%8D%AF%E7%89%A9%E4%BC%9A%E6%9B%B4%E5%BC%BA%E5%90%97%EF%BC%9F\" >02\u3001\u5e15\u91d1\u68ee\u75c5\u6cbb\u7597\u4e2d\uff0cTavapadon\u4e0e\u5de6\u65cb\u591a\u5df4\u7684\u6bd4\u8f83\uff1a\u827e\u4f2f\u7ef4\u7684\u836f\u7269\u4f1a\u66f4\u5f3a\u5417\uff1f<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/www.hjtdsm.cn\/en\/research\/ns\/pd\/20370.html\/#03%E3%80%81Denali_Therapeutics%E5%85%AC%E5%8F%B8%E7%9A%84BIIB122%E5%92%8CNRG%E5%85%AC%E5%8F%B8%E7%9A%84NRG5051%E8%BF%99%E4%B8%A4%E7%A7%8D%E5%B0%8F%E5%88%86%E5%AD%90%E8%8D%AF%E7%89%A9%E6%97%A8%E5%9C%A8%E5%BB%B6%E7%BC%93%E7%A5%9E%E7%BB%8F%E9%80%80%E8%A1%8C%E6%80%A7%E7%96%BE%E7%97%85%E7%9A%84%E5%8F%91%E7%94%9F\" >03\u3001Denali Therapeutics\u516c\u53f8\u7684BIIB122\u548cNRG\u516c\u53f8\u7684NRG5051\u8fd9\u4e24\u79cd\u5c0f\u5206\u5b50\u836f\u7269\u65e8\u5728\u5ef6\u7f13\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u7684\u53d1\u751f<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/www.hjtdsm.cn\/en\/research\/ns\/pd\/20370.html\/#04%E3%80%81%E7%BB%93%E8%AE%BA%E4%B8%8D%E4%B8%80%EF%BC%9AGLP-1%E8%83%BD%E5%90%A6%E6%B2%BB%E7%96%97%E5%B8%95%E9%87%91%E6%A3%AE%E7%97%85%EF%BC%9F\" >04\u3001\u7ed3\u8bba\u4e0d\u4e00\uff1aGLP-1\u80fd\u5426\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\uff1f<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/www.hjtdsm.cn\/en\/research\/ns\/pd\/20370.html\/#05%E3%80%81Askbio%E3%80%81Prevail_Therapeutics%E5%92%8CCapsida_Biotherapeutics%E6%AD%A3%E5%9C%A8%E6%8E%A8%E8%BF%9B%E5%B8%95%E9%87%91%E6%A3%AE%E7%97%85%E5%9F%BA%E5%9B%A0%E7%96%97%E6%B3%95%E7%9A%84%E5%8F%91%E5%B1%95\" >05\u3001Askbio\u3001Prevail Therapeutics\u548cCapsida Biotherapeutics\u6b63\u5728\u63a8\u8fdb\u5e15\u91d1\u68ee\u75c5\u57fa\u56e0\u7597\u6cd5\u7684\u53d1\u5c55<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/www.hjtdsm.cn\/en\/research\/ns\/pd\/20370.html\/#06%E3%80%81%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%EF%BC%9A%E4%BF%AE%E5%A4%8D%E5%8F%97%E6%8D%9F%E5%A4%A7%E8%84%91%E7%9A%84%E6%96%B0%E5%B8%8C%E6%9C%9B\" >06\u3001\u5e72\u7ec6\u80de\u6cbb\u7597\uff1a\u4fee\u590d\u53d7\u635f\u5927\u8111\u7684\u65b0\u5e0c\u671b<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/www.hjtdsm.cn\/en\/research\/ns\/pd\/20370.html\/#07%E3%80%81RNA%E5%B9%B2%E6%89%B0%E6%98%AF%E8%A7%A3%E5%86%B3%E9%97%AE%E9%A2%98%E7%9A%84%E6%AD%A3%E7%A1%AE%E6%96%B9%E6%B3%95%E5%90%97%EF%BC%9F\" >07\u3001RNA\u5e72\u6270\u662f\u89e3\u51b3\u95ee\u9898\u7684\u6b63\u786e\u65b9\u6cd5\u5417\uff1f<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/www.hjtdsm.cn\/en\/research\/ns\/pd\/20370.html\/#08%E3%80%81%E5%B8%95%E9%87%91%E6%A3%AE%E7%97%85%EF%BC%9A%E7%BD%97%E6%B0%8F%E5%8D%95%E5%85%8B%E9%9A%86%E6%8A%97%E4%BD%93prasinezumab%E5%85%8B%E6%9C%8D%E6%8C%AB%E6%8A%98\" >08\u3001\u5e15\u91d1\u68ee\u75c5\uff1a\u7f57\u6c0f\u5355\u514b\u9686\u6297\u4f53prasinezumab\u514b\u670d\u632b\u6298<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/www.hjtdsm.cn\/en\/research\/ns\/pd\/20370.html\/#%E6%80%BB%E7%BB%93\" >\u603b\u7ed3<\/a><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"%E6%AD%A3%E5%9C%A8%E5%BC%80%E5%8F%91%E6%B2%BB%E7%96%97%E5%B8%95%E9%87%91%E6%A3%AE%E7%97%85%E7%9A%84%E6%96%B9%E6%B3%95%EF%BC%9A%E5%B9%B2%E7%BB%86%E8%83%9E%E3%80%81%E5%9F%BA%E5%9B%A0%E7%96%97%E6%B3%95%E4%B8%8E%E6%96%B0%E8%8D%AF%E5%A6%82%E4%BD%95%E9%87%8D%E5%A1%91%E6%9C%AA%E6%9D%A5\"><\/span>\u6b63\u5728\u5f00\u53d1\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\u7684\u65b9\u6cd5\uff1a\u5e72\u7ec6\u80de\u3001\u57fa\u56e0\u7597\u6cd5\u4e0e\u65b0\u836f\u5982\u4f55\u91cd\u5851\u672a\u6765<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<h2><span class=\"ez-toc-section\" id=\"%E7%9B%AE%E5%BD%95\"><\/span><strong><span class=\"wx_text_underline\">\u76ee\u5f55<\/span><\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<section data-role=\"list\">\n<ul class=\"list-paddingleft-1\">\n<li>01\u3001\u591a\u5df4\u80fa\u7f3a\u4e4f\uff1a\u5e15\u91d1\u68ee\u75c5\u5982\u4f55\u5f71\u54cd\u8eab\u4f53\uff1f<\/li>\n<li>02\u3001\u5e15\u91d1\u68ee\u75c5\u6cbb\u7597\u4e2d\uff0cTavapadon\u4e0e\u5de6\u65cb\u591a\u5df4\u7684\u6bd4\u8f83\uff1a\u827e\u4f2f\u7ef4\u7684\u836f\u7269\u4f1a\u66f4\u5f3a\u5417\uff1f<\/li>\n<li>03\u3001Denali Therapeutics\u516c\u53f8\u7684BIIB122\u548cNRG\u516c\u53f8\u7684<span class=\"\">NRG<\/span>5051\u8fd9\u4e24\u79cd\u5c0f\u5206\u5b50\u836f\u7269\u65e8\u5728\u5ef6\u7f13\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u7684\u53d1\u751f<\/li>\n<\/ul>\n<ul class=\"list-paddingleft-1\">\n<li>04\u3001\u7ed3\u8bba\u4e0d\u4e00\uff1aGLP-1\u80fd\u5426\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\uff1f<\/li>\n<li>05\u3001Askbio\u3001Prevail Therapeutics\u548cCapsida Biotherapeutics\u6b63\u5728\u63a8\u8fdb\u5e15\u91d1\u68ee\u75c5\u57fa\u56e0\u7597\u6cd5\u7684\u53d1\u5c55<\/li>\n<li>\n<section data-role=\"list\">06\u3001\u5e72\u7ec6\u80de\u6cbb\u7597\uff1a\u4fee\u590d\u53d7\u635f\u5927\u8111\u7684\u65b0\u5e0c\u671b<\/p>\n<\/section>\n<\/li>\n<li>07\u3001RNA\u5e72\u6270\u662f\u89e3\u51b3\u95ee\u9898\u7684\u6b63\u786e\u65b9\u6cd5\u5417\uff1f<\/li>\n<li>08\u3001\u5e15\u91d1\u68ee\u75c5\uff1a\u7f57\u6c0f\u5355\u514b\u9686\u6297\u4f53prasinezumab\u514b\u670d\u632b\u6298<\/li>\n<\/ul>\n<\/section>\n<h2><span class=\"ez-toc-section\" id=\"01%E3%80%81%E5%A4%9A%E5%B7%B4%E8%83%BA%E7%BC%BA%E4%B9%8F%EF%BC%9A%E5%B8%95%E9%87%91%E6%A3%AE%E7%97%85%E5%A6%82%E4%BD%95%E5%BD%B1%E5%93%8D%E8%BA%AB%E4%BD%93%EF%BC%9F\"><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">01\u3001\u591a\u5df4\u80fa\u7f3a\u4e4f\uff1a\u5e15\u91d1\u68ee\u75c5\u5982\u4f55\u5f71\u54cd\u8eab\u4f53\uff1f<\/span><\/span><\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>\u4e0e\u5de6\u65cb\u591a\u5df4\u4e0d\u540c\uff0c\u5de6\u65cb\u591a\u5df4\u5230\u8fbe\u5927\u8111\u540e\u4f1a\u8f6c\u5316\u4e3a\u591a\u5df4\u80fa\uff0c\u800c\u672c\u6587\u8ba8\u8bba\u7684\u836f\u7269\u4ed6\u4f10\u5e15\u987f\u5219\u901a\u8fc7\u6fc0\u6d3b\u5927\u8111\u4e2d\u4e0e\u591a\u5df4\u80fa\u751f\u6210\u76f8\u5173\u7684\u53d7\u4f53\u6765\u6a21\u62df\u591a\u5df4\u80fa\u7684\u4f5c\u7528\u3002\u591a\u5df4\u80fa\u65e2\u662f\u4e00\u79cd\u795e\u7ecf\u9012\u8d28\uff08\u4e00\u79cd\u5c06\u4fe1\u53f7\u4ece\u795e\u7ecf\u7ec6\u80de\u4f20\u9012\u5230\u9776\u7ec6\u80de\u7684\u5316\u5b66\u7269\u8d28\uff09\uff0c\u4e5f\u662f\u4e00\u79cd\u6fc0\u7d20\uff0c\u5176\u529f\u80fd\u969c\u788d\u4e0e\u591a\u79cd\u795e\u7ecf\u548c\u7cbe\u795e\u75be\u75c5\u6709\u5173\uff0c\u5305\u62ec\u5e15\u91d1\u68ee\u75c5\u3002<\/p>\n<p>\u4e8b\u5b9e\u4e0a\uff0c\u591a\u5df4\u80fa\u7f3a\u4e4f\u662f\u5e15\u91d1\u68ee\u75c5\u7684\u4e3b\u8981\u75c5\u56e0\u3002\u5f53\u4ea7\u751f\u591a\u5df4\u80fa\u7684\u795e\u7ecf\u7ec6\u80de\u6b7b\u4ea1\u65f6\uff0c\u6fc0\u7d20\u6c34\u5e73\u4e0b\u964d\uff0c\u5bfc\u81f4\u9707\u98a4\u3001\u50f5\u786c\u548c\u8fd0\u52a8\u8fdf\u7f13\u7b49\u75c7\u72b6\u3002\u8fd9\u79cd\u75be\u75c5\u6700\u65e9\u4e8e1817\u5e74\u88ab\u63cf\u8ff0\u4e3a\u4e00\u79cd\u795e\u7ecf\u7cfb\u7edf\u7efc\u5408\u5f81\uff0c\u5e76\u4ee5\u82f1\u56fd\u5916\u79d1\u533b\u751f\u8a79\u59c6\u65af\u00b7\u5e15\u91d1\u68ee\u7684\u540d\u5b57\u547d\u540d\u3002<\/p>\n<section>\n<div id=\"attachment_20374\" style=\"width: 201px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-20374\" class=\"wp-image-20374 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5fae\u4fe1\u56fe\u7247_2025-11-07_134822_167.png\" alt=\"\u8a79\u59c6\u65af\u00b7\u5e15\u91d1\u68ee\" width=\"191\" height=\"217\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5fae\u4fe1\u56fe\u7247_2025-11-07_134822_167.png 191w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5fae\u4fe1\u56fe\u7247_2025-11-07_134822_167-11x12.png 11w\" sizes=\"(max-width: 191px) 100vw, 191px\" \/><p id=\"caption-attachment-20374\" class=\"wp-caption-text\">\u8a79\u59c6\u65af\u00b7\u5e15\u91d1\u68ee<\/p><\/div>\n<\/section>\n<p>\u5e15\u91d1\u68ee\u6700\u8457\u540d\u7684\u8457\u4f5c\u662f\u300a\u8bba\u9707\u98a4\u9ebb\u75f9\u75c7\u300b\uff0c\u8fd9\u662f\u4e00\u90e8\u5173\u4e8e\u8fd9\u79cd\u5bfc\u81f4\u8fd0\u52a8\u969c\u788d\u7684\u81f4\u6b8b\u6027\u75be\u75c5\u7684\u4e34\u5e8a\u62a5\u544a\u3002\u7136\u800c\uff0c\u65e9\u5728\u516c\u5143\u524d1000\u5e74\uff0c\u53e4\u5370\u5ea6\u6587\u732e\u548c\u4e2d\u56fd\u53f2\u6599\u4e2d\u4f3c\u4e4e\u5c31\u8bb0\u8f7d\u4e86\u5bf9\u5e15\u91d1\u68ee\u75c5\u7684\u63cf\u8ff0\u3002<\/p>\n<p>\u5e15\u91d1\u68ee\u75c5\u4e0e\u5176\u4ed6\u9707\u98a4\u6027\u75be\u75c5\uff08\u7279\u522b\u662f\u591a\u53d1\u6027\u786c\u5316\u75c7\uff09\u7684\u533a\u522b\u5728\u4e8e\uff0c\u6cd5\u56fd\u795e\u7ecf\u5b66\u5bb6\u8ba9-\u9a6c\u4e01\u00b7\u6c99\u5c14\u79d1\uff08Jean-Martin Charcot\uff09\u53d1\u73b0\u5e76\u975e\u6240\u6709\u5e15\u91d1\u68ee\u75c5\u60a3\u8005\u90fd\u4f1a\u51fa\u73b0\u9707\u98a4\uff0c\u800c\u4ed6\u4e5f\u4e3a\u8fd9\u79cd\u75be\u75c5\u547d\u540d\u3002<\/p>\n<p>\u7814\u7a76\u4eba\u5458\u8fd8\u80fd\u591f\u533a\u5206\u5e15\u91d1\u68ee\u75c5\u548c\u5e15\u91d1\u68ee\u7efc\u5408\u5f81\u2014\u2014\u5e15\u91d1\u68ee\u7efc\u5408\u5f81\u662f\u4e00\u4e2a\u603b\u79f0\uff0c\u7528\u4e8e\u63cf\u8ff0\u4e0e\u5e15\u91d1\u68ee\u75c5\u7c7b\u4f3c\u7684\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\uff0c\u5176\u7279\u5f81\u901a\u5e38\u5305\u62ec\u9707\u98a4\u3001\u8fd0\u52a8\u8fdf\u7f13\u548c\u50f5\u786c\u3002\u5728\u5e15\u91d1\u68ee\u7684\u8457\u4f5c\u51fa\u7248\u4e00\u4e2a\u591a\u4e16\u7eaa\u540e\uff0c\u79d1\u5b66\u5bb6\u4eec\u624d\u53d1\u73b0\u591a\u5df4\u80fa\u4e0e\u5e15\u91d1\u68ee\u75c5\u4e4b\u95f4\u7684\u8054\u7cfb\u3002\u5f53\u65f6\uff0c\u79d1\u5b66\u5bb6\u4eec\u53d1\u73b0\u6b7b\u4e8e\u5e15\u91d1\u68ee\u75c5\u7684\u4eba\u7684\u5927\u8111\u4e2d\u591a\u5df4\u80fa\u542b\u91cf\u663e\u8457\u964d\u4f4e\u3002<\/p>\n<h2><span class=\"ez-toc-section\" id=\"02%E3%80%81%E5%B8%95%E9%87%91%E6%A3%AE%E7%97%85%E6%B2%BB%E7%96%97%E4%B8%AD%EF%BC%8CTavapadon%E4%B8%8E%E5%B7%A6%E6%97%8B%E5%A4%9A%E5%B7%B4%E7%9A%84%E6%AF%94%E8%BE%83%EF%BC%9A%E8%89%BE%E4%BC%AF%E7%BB%B4%E7%9A%84%E8%8D%AF%E7%89%A9%E4%BC%9A%E6%9B%B4%E5%BC%BA%E5%90%97%EF%BC%9F\"><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">02\u3001\u5e15\u91d1\u68ee\u75c5\u6cbb\u7597\u4e2d\uff0cTavapadon\u4e0e\u5de6\u65cb\u591a\u5df4\u7684\u6bd4\u8f83\uff1a\u827e\u4f2f\u7ef4\u7684\u836f\u7269\u4f1a\u66f4\u5f3a\u5417\uff1f<\/span><\/span><\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>\u5df2\u8bc1\u5b9e\uff0cTavapadon\u53ef\u4ee5\u6fc0\u6d3b\u7279\u5b9a\u7684\u591a\u5df4\u80fa\u53d7\u4f53D1\u548cD5\uff0c\u800c\u4e0d\u4f1a\u8fc7\u5ea6\u523a\u6fc0\u5176\u4ed6\u591a\u5df4\u80fa\u53d7\u4f53\uff0c\u5982D2\u3001D3\u548cD4\uff0c\u4ece\u800c\u907f\u514d\u4ea7\u751f\u5e7b\u89c9\u548c\u51b2\u52a8\u63a7\u5236\u969c\u788d\u7b49\u526f\u4f5c\u7528\u3002<\/p>\n<p>\u73b0\u5728\uff0c\u5b83\u8ddd\u79bb\u83b7\u6279\u6bd4\u4ee5\u5f80\u4efb\u4f55\u65f6\u5019\u90fd\u66f4\u8fd1\u4e86\u4e00\u6b65\u3002\u5176\u7814\u53d1\u8005\uff0c\u7f8e\u56fd\u5236\u836f\u5de8\u5934\u827e\u4f2f\u7ef4\u516c\u53f8\uff0c\u5728\u4e0a\u4e2a\u6708\u5411\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u63d0\u4ea4\u4e86\u4e0a\u5e02\u7533\u8bf7\u3002\u6b64\u524d\uff0c\u4e00\u98793\u671f\u4e34\u5e8a\u8bd5\u9a8c\u53d6\u5f97\u4e86\u79ef\u6781\u7ed3\u679c\uff0c\u8fdb\u4e00\u6b65\u8bc1\u5b9e\u4e86tavapadon\u5728\u6cbb\u7597\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u65b9\u9762\u7684\u6f5c\u529b\u3002<\/p>\n<section>\n<div id=\"attachment_20385\" style=\"width: 1168px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-20385\" class=\"wp-image-20385 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-07_111106_326.png\" alt=\"\" width=\"1158\" height=\"362\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-07_111106_326.png 1158w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-07_111106_326-300x94.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-07_111106_326-1024x320.png 1024w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-07_111106_326-768x240.png 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-07_111106_326-18x6.png 18w\" sizes=\"(max-width: 1158px) 100vw, 1158px\" \/><p id=\"caption-attachment-20385\" class=\"wp-caption-text\">\u827e\u4f2f\u7ef4\u516c\u53f8\u5411\u7f8e\u56fdFDA\u63d0\u4ea4\u7528\u4e8e\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\u7684Tavapadon\u65b0\u836f\u7533\u8bf7<\/p><\/div>\n<\/section>\n<p>\u8be5\u7597\u6cd5\u6210\u529f\u63d0\u9ad8\u4e86\u60a3\u8005\u5728\u8fd0\u52a8\u969c\u788d\u534f\u4f1a-\u7edf\u4e00\u5e15\u91d1\u68ee\u75c5\u8bc4\u5b9a\u91cf\u8868\uff08MDS-UPDRS\uff09\u4e0a\u7684\u5f97\u5206\uff0c\u8be5\u91cf\u8868\u7528\u4e8e\u8bc4\u4f30\u8fd0\u52a8\u75c7\u72b6\uff08\u5f71\u54cd\u8fd0\u52a8\u548c\u5e73\u8861\u7684\u8eab\u4f53\u4f53\u5f81\uff09\u548c\u975e\u8fd0\u52a8\u75c7\u72b6\u3002<\/p>\n<p>\u6b64\u5916\uff0c\u60a3\u8005\u5728\u670d\u836f\u671f\u95f4\u201c\u6709\u6548\u201d\u65f6\u95f4\u66f4\u957f\uff0c\u75c7\u72b6\u5f97\u5230\u4e86\u826f\u597d\u63a7\u5236\uff0c\u672a\u51fa\u73b0\u4efb\u4f55\u4e0d\u81ea\u4e3b\u4e14\u4e0d\u7a33\u5b9a\u7684\u52a8\u4f5c\u3002\u201c\u6709\u6548\u65f6\u95f4\u201d\u662f\u6307\u5e15\u91d1\u68ee\u836f\u7269\u5728\u4e00\u5929\u4e2d\u6b63\u5e38\u53d1\u6325\u4f5c\u7528\u7684\u65f6\u95f4\uff0c\u201c\u65e0\u6548\u65f6\u95f4\u201d\u5219\u662f\u6307\u5728\u4e0b\u4e00\u6b21\u670d\u836f\u524d\u75c7\u72b6\u590d\u53d1\u7684\u65f6\u95f4\u3002\u65e0\u6548\u65f6\u95f4\u901a\u5e38\u53d1\u751f\u5728\u65e9\u6668\u9996\u6b21\u670d\u836f\u524d\u4ee5\u53ca\u4e24\u6b21\u670d\u836f\u4e4b\u95f4\u7684\u95f4\u9694\u671f\u3002<\/p>\n<p>\u8fd9\u662f\u5224\u65ad\u5e15\u91d1\u68ee\u75c5\u7597\u6cd5\u662f\u5426\u6709\u6548\u7684\u5173\u952e\u56e0\u7d20\u3002\u836f\u7269\u8d77\u6548\u65f6\u95f4\u8d8a\u957f\uff0c\u5bf9\u60a3\u8005\u8d8a\u6709\u5229\u3002\u4e0e\u5de6\u65cb\u591a\u5df4\u76f8\u6bd4\uff0c\u670d\u7528\u4ed6\u4f10\u5e15\u916e\u7684\u60a3\u8005\u66f4\u4e0d\u5bb9\u6613\u51fa\u73b0\u201c\u5f00\u5173\u201d\u6548\u5e94\uff0c\u56e0\u4e3a\u524d\u8005\u7684\u534a\u8870\u671f\u66f4\u957f\u2014\u2014\u836f\u7269\u6d3b\u6027\u6210\u5206\u6d53\u5ea6\u51cf\u534a\u6240\u9700\u7684\u65f6\u95f4\u3002<\/p>\n<p>\u201c\u5bf9\u4e8e\u8bb8\u591a\u5e15\u91d1\u68ee\u75c5\u60a3\u8005\u6765\u8bf4\uff0c\u76ee\u524d\u7684\u53e3\u670d\u6807\u51c6\u7597\u6cd5\u4e0d\u8db3\u4ee5\u6709\u6548\u63a7\u5236\u75c7\u72b6\uff0c\u201d\u827e\u4f2f\u7ef4\u516c\u53f8\u7814\u53d1\u6267\u884c\u526f\u603b\u88c1\u517c\u9996\u5e2d\u79d1\u5b66\u5b98\u9c81\u5e15\u5c14\u00b7\u5854\u5361\u5c14\u5728\u4e00\u4efd\u65b0\u95fb\u7a3f\u4e2d\u8868\u793a\u3002\u201c\u6211\u4eec\u8ba4\u8bc6\u5230\u5e15\u91d1\u68ee\u75c5\u5bf9\u60a3\u8005\u8eab\u5fc3\u5065\u5eb7\u7684\u5f71\u54cd\uff0c\u5e76\u81f4\u529b\u4e8e\u63d0\u4f9b\u65b0\u4e00\u4ee3\u6cbb\u7597\u65b9\u6848\uff0c\u5e2e\u52a9\u60a3\u8005\u5728\u75be\u75c5\u7684\u5404\u4e2a\u9636\u6bb5\u6062\u590d\u8fd0\u52a8\u63a7\u5236\u80fd\u529b\u548c\u72ec\u7acb\u751f\u6d3b\u80fd\u529b\u3002\u201d<\/p>\n<p>\u968f\u7740tavapadon\u7684\u65b0\u836f\u7533\u8bf7\uff08NDA\uff09\u63d0\u4ea4\u7ed9FDA\u8fdb\u884c\u5ba1\u67e5\uff0c\u5c0f\u5206\u5b50\u836f\u7269\u5728\u5e15\u91d1\u68ee\u75c5\u7814\u7a76\u9886\u57df\u6b63\u84ec\u52c3\u53d1\u5c55\u3002\u5b9e\u9a8c\u6027\u5c0f\u5206\u5b50\u836f\u7269BIIB122\u6b63\u662f\u8fd9\u4e00\u53d1\u5c55\u52bf\u5934\u7684\u4e00\u90e8\u5206\uff0c\u5b83\u76ee\u524d\u6b63\u5728\u8fdb\u884c\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u7528\u4e8e\u6cbb\u7597\u7531\u57fa\u56e0\u7a81\u53d8\u5f15\u8d77\u7684\u6700\u5e38\u89c1\u5e15\u91d1\u68ee\u75c5\u7c7b\u578b\u3002<\/p>\n<p>LRRK2\u57fa\u56e0\u63a7\u5236\u7740\u4e00\u79cd\u8d1f\u8d23\u7ec6\u80de\u5185\u591a\u79cd\u4fe1\u53f7\u901a\u8def\u7684\u86cb\u767d\u8d28\u3002\u7136\u800c\uff0c\u8be5\u57fa\u56e0\u7684\u7a81\u53d8\u4f1a\u523a\u6fc0\u4e00\u79cd\u540d\u4e3aLRRK2\u86cb\u767d\u6fc0\u9176\u7684\u9176\u8fc7\u5ea6\u6d3b\u8dc3\uff0c\u4ece\u800c\u6270\u4e71\u8fd9\u4e9b\u4fe1\u53f7\u901a\u8def\uff0c\u7279\u522b\u662f\u53c2\u4e0e\u591a\u5df4\u80fa\u751f\u6210\u7684\u4fe1\u53f7\u901a\u8def\uff0c\u6700\u7ec8\u5bfc\u81f4\u5e15\u91d1\u68ee\u75c5\u3002<\/p>\n<h2><span class=\"ez-toc-section\" id=\"03%E3%80%81Denali_Therapeutics%E5%85%AC%E5%8F%B8%E7%9A%84BIIB122%E5%92%8CNRG%E5%85%AC%E5%8F%B8%E7%9A%84NRG5051%E8%BF%99%E4%B8%A4%E7%A7%8D%E5%B0%8F%E5%88%86%E5%AD%90%E8%8D%AF%E7%89%A9%E6%97%A8%E5%9C%A8%E5%BB%B6%E7%BC%93%E7%A5%9E%E7%BB%8F%E9%80%80%E8%A1%8C%E6%80%A7%E7%96%BE%E7%97%85%E7%9A%84%E5%8F%91%E7%94%9F\"><\/span><strong>03\u3001Denali Therapeutics\u516c\u53f8\u7684BIIB122\u548cNRG\u516c\u53f8\u7684NRG5051\u8fd9\u4e24\u79cd\u5c0f\u5206\u5b50\u836f\u7269\u65e8\u5728\u5ef6\u7f13\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u7684\u53d1\u751f<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>BIIB122\u7597\u6cd5\u7531Denali Therapeutics\u516c\u53f8\u7814\u53d1\uff0c\u65e8\u5728\u6291\u5236\u8be5\u9176\u7684\u6d3b\u6027\u3002\u8fd9\u5bb6\u603b\u90e8\u4f4d\u4e8e\u52a0\u5dde\u7684\u751f\u7269\u6280\u672f\u516c\u53f8\u5df2\u4e0e\u7f8e\u56fd\u8de8\u56fd\u5236\u836f\u516c\u53f8Biogen\u5408\u4f5c\uff0c\u4ee5\u52a0\u5feb\u5176\u4e34\u5e8a\u5f00\u53d1\u3002\u4f46\u8fc4\u4eca\u4e3a\u6b62\uff0c\u8be5\u836f\u7269\u7684\u4e34\u5e8a\u8bd5\u9a8c\u8fdb\u5c55\u5e76\u4e0d\u987a\u5229\u3002<\/p>\n<p>\u4e24\u5e74\u524d\uff0c\u4e00\u9879\u9488\u5bf9\u5e15\u91d1\u68ee\u75c5\u76843\u671f\u4e34\u5e8a\u8bd5\u9a8c\u88ab\u7ec8\u6b62\u3002\u8be5\u516c\u53f8\u58f0\u79f0\uff0c\u4ed6\u4eec\u5e0c\u671b\u5c06\u201c\u7cbe\u529b\u91cd\u65b0\u96c6\u4e2d\u201d\u4e8e\u8be5\u836f\u7269\u76842\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u76ee\u524d\u8be5\u8bd5\u9a8c\u6b63\u5728\u8fdb\u884c\u4e2d\u3002\u8fd9\u9879\u8bd5\u9a8c\u5c06\u6d4b\u8bd5\u8fd9\u79cd\u5c0f\u5206\u5b50\u836f\u7269\u5bf930\u81f380\u5c81\u65e9\u671f\u5e15\u91d1\u68ee\u75c5\u60a3\u8005\uff08\u5373\u5165\u7ec4\u524d\u4e24\u5e74\u5185\u786e\u8bca\u7684\u60a3\u8005\uff09\u7684\u7597\u6548\uff0c\u9884\u8ba1\u5c06\u4e8e\u4e00\u5e74\u5185\u7ed3\u675f\u3002<\/p>\n<p>\u7d27\u968f\u5176\u540e\u7684\u662f\u4e00\u4e9b\u6b63\u5728\u8fdb\u5165\u4e34\u5e8a\u8bd5\u9a8c\u9636\u6bb5\u7684\u5c0f\u5206\u5b50\u836f\u7269\u3002\u4f8b\u5982\uff0cNRG Therapeutics\u516c\u53f8\u7814\u53d1\u7684\u9776\u5411\u7ebf\u7c92\u4f53\u7684\u6291\u5236\u5242\u836f\u7269\uff0c\u7ebf\u7c92\u4f53\u7d20\u88ab\u8a89\u4e3a\u7ec6\u80de\u7684\u80fd\u91cf\u5de5\u5382\u3002<\/p>\n<p>NRG\u516c\u53f8\u7684NRG5051\u9776\u5411\u4e00\u79cd\u540d\u4e3a\u7ebf\u7c92\u4f53\u901a\u900f\u6027\u8f6c\u6362\u5b54\uff08mPTP\uff09\u7684\u901a\u9053\uff0c\u8be5\u901a\u9053\u5728\u9ad8\u5e94\u6fc0\u6761\u4ef6\u4e0b\u4f1a\u6253\u5f00\uff0c\u901a\u5411\u7ebf\u7c92\u4f53\u819c\u3002\u5f53TDP-43\u548c<span class=\"\">\u03b1-\u7a81\u89e6\u6838\u86cb\u767d<\/span>\uff08\u5e15\u91d1\u68ee\u75c5\u7684\u4e24\u79cd\u6807\u5fd7\u6027\u86cb\u767d\uff09\u7b49\u9519\u8bef\u6298\u53e0\u86cb\u767d\u79ef\u7d2f\u65f6\uff0c\u4f1a\u5bfc\u81f4\u7ec6\u80de\u6b7b\u4ea1\uff0c\u8fdb\u800c\u7834\u574f\u795e\u7ecf\u5143\u3002<\/p>\n<p>\u8be5\u836f\u7269\u5df2\u5b8c\u6210\u65b0\u836f\u7814\u7a76\u7533\u8bf7\uff08IND\uff09\u6240\u9700\u7814\u7a76\uff0c\u6709\u671b\u4e8e\u660e\u5e74\u521d\u8fdb\u5165\u4e34\u5e8a\u8bd5\u9a8c\u9636\u6bb5\u3002\u5c31\u5728\u4e0a\u4e2a\u6708\uff0c\u8be5\u836f\u7269\u5728B\u8f6e\u878d\u8d44\u4e2d\u7b79\u96c6\u4e865000\u4e07\u82f1\u9551\uff08\u7ea6\u54086700\u4e07\u7f8e\u5143\uff09\uff0c\u7528\u4e8e\u542f\u52a8\u5e15\u91d1\u68ee\u75c5\u548c\u808c\u840e\u7f29\u4fa7\u7d22\u786c\u5316\u75c7\uff08\u53e6\u4e00\u79cd\u5f71\u54cd\u8fd0\u52a8\u795e\u7ecf\u5143\u7684\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\uff09\u7684\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/p>\n<h2><span class=\"ez-toc-section\" id=\"04%E3%80%81%E7%BB%93%E8%AE%BA%E4%B8%8D%E4%B8%80%EF%BC%9AGLP-1%E8%83%BD%E5%90%A6%E6%B2%BB%E7%96%97%E5%B8%95%E9%87%91%E6%A3%AE%E7%97%85%EF%BC%9F\"><\/span><strong>04\u3001\u7ed3\u8bba\u4e0d\u4e00\uff1aGLP-1\u80fd\u5426\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\uff1f<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>\u968f\u7740\u4eba\u4eec\u5bf9\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u7814\u7a76\u7684\u5174\u8da3\u65e5\u76ca\u6d53\u539a\uff0c\u5c0f\u5206\u5b50\u836f\u7269\u4e5f\u968f\u4e4b\u5174\u8d77\uff0c\u79d1\u5b66\u5bb6\u4eec\u6b63\u5728\u63a2\u7d22GLP-1\u53d7\u4f53\u6fc0\u52a8\u5242\u662f\u5426\u80fd\u591f\u6cbb\u7597\u8fd9\u79cd\u75be\u75c5\u3002\u867d\u7136GLP-1\u53d7\u4f53\u6fc0\u52a8\u5242\u5728\u51cf\u80a5\u9886\u57df\u58f0\u540d\u9e4a\u8d77\uff0c\u4f46\u8fc4\u4eca\u4e3a\u6b62\uff0c\u5176\u5728\u5e15\u91d1\u68ee\u75c5\u6cbb\u7597\u65b9\u9762\u7684\u8fdb\u5c55\u5374\u5e76\u4e0d\u7406\u60f3\u3002<\/p>\n<p>\u66fe\u88ab\u5bc4\u4e88\u539a\u671b\u7684\u5019\u9009\u836f\u7269\u827e\u585e\u90a3\u80bd\uff0c\u4f462\u6708\u4efd\u516c\u5e03\u7684\u7cdf\u7cd5\u8bd5\u9a8c\u7ed3\u679c\u7c89\u788e\u4e86\u5e15\u91d1\u68ee\u75c5\u60a3\u8005\u7684\u5e0c\u671b\u3002\u4f26\u6566\u5927\u5b66\u5b66\u9662\uff08UCL\uff09\u7684\u7814\u7a76\u4eba\u5458\u6ca1\u6709\u53d1\u73b0\u4efb\u4f55\u8bc1\u636e\u8868\u660e\u8be5\u836f\u7269\u80fd\u591f\u963b\u6b62\u75be\u75c5\u8fdb\u5c55\u3002\u6b64\u5916\uff0c\u53f8\u7f8e\u683c\u9c81\u80bd\u2014\u2014\u8457\u540d\u836f\u7269<span class=\"\">Ozempic<\/span>\u548cWegovy\u7684\u4e3b\u8981\u6210\u5206\u2014\u2014\u5728\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\u65b9\u9762\u4e5f\u6536\u6548\u751a\u5fae\u3002<\/p>\n<section>\n<div id=\"attachment_20384\" style=\"width: 1090px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-20384\" class=\"wp-image-20384 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-07_111544_078.png\" alt=\"\" width=\"1080\" height=\"378\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-07_111544_078.png 1080w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-07_111544_078-300x105.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-07_111544_078-1024x358.png 1024w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-07_111544_078-768x269.png 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-07_111544_078-18x6.png 18w\" sizes=\"(max-width: 1080px) 100vw, 1080px\" \/><p id=\"caption-attachment-20384\" class=\"wp-caption-text\">\u5728\u82f1\u56fd\u5f00\u5c55\u7684\u4e00\u98793\u671f\u3001\u591a\u4e2d\u5fc3\u3001\u53cc\u76f2\u3001\u5e73\u884c\u7ec4\u3001\u968f\u673a\u3001\u5b89\u6170\u5242\u5bf9\u7167\u8bd5\u9a8c\uff0c\u65e8\u5728\u8bc4\u4f30\u6bcf\u5468\u4e00\u6b21\u827e\u585e\u90a3\u80bd\u4e0e\u5b89\u6170\u5242\u4f5c\u4e3a\u5e15\u91d1\u68ee\u75c5\u60a3\u8005\u6f5c\u5728\u75be\u75c5\u6539\u5584\u7597\u6cd5\u7684\u7597\u6548\u3002<\/p><\/div>\n<\/section>\n<p>\u7136\u800c\uff0c\u5236\u836f\u5de8\u5934\u8d5b\u8bfa\u83f2\u5df2\u505c\u6b62\u7814\u53d1\u7684GLP-1\u53d7\u4f53\u6fc0\u52a8\u5242\u5229\u897f\u62c9\u80bd\u5728\u65e9\u671f\u4e34\u5e8a\u7814\u7a76\u4e2d\u53d6\u5f97\u4e86\u8fdb\u5c55\u3002\u8be5\u836f\u7269\u5df2\u6210\u529f\u7a7f\u8fc7\u8840\u8111\u5c4f\u969c\uff0c\u8fd9\u5bf9\u4e8e\u5e15\u91d1\u68ee\u75c5\u836f\u7269\u53d1\u6325\u7597\u6548\u81f3\u5173\u91cd\u8981\u3002\u53bb\u5e74\u7684\u4e00\u9879\u4e8c\u671f\u4e34\u5e8a\u8bd5\u9a8c\u53d1\u73b0\uff0c\u8be5\u836f\u7269\u53ef\u4ee5\u5ef6\u7f13\u60a3\u8005\u8fd0\u52a8\u76f8\u5173\u75c7\u72b6\u7684\u53d1\u5c55\u3002<\/p>\n<p>MDS-UPDRS\u8bc4\u5206\u8303\u56f4\u4e3a0\u81f3132\u5206\uff0c\u4ee3\u8868\u8fd0\u52a8\u529f\u80fd\u969c\u788d\u7a0b\u5ea6\u52a0\u91cd\u3002\u8bd5\u9a8c\u5f00\u59cb\u4e00\u5e74\u540e\uff0c\u6cbb\u7597\u7ec4\u7684\u8bc4\u5206\u63d0\u9ad8\u4e860.04\u5206\uff0c\u5b89\u6170\u5242\u7ec4\u63d0\u9ad8\u4e863.04\u5206\u3002\u968f\u540e\uff0c\u60a3\u8005\u505c\u7528\u836f\u7269\u548c\u5b89\u6170\u5242\u4e24\u4e2a\u6708\uff0c\u7ed3\u679c\u663e\u793a\u4e24\u7ec4\u8bc4\u5206\u76f8\u5dee3\u5206\u3002\u5c3d\u7ba1\u8fd9\u4e9b\u6570\u636e\u672c\u8eab\u53ef\u80fd\u5e76\u4e0d\u5177\u6709\u7a81\u7834\u6027\uff0c\u4f46\u7814\u7a76\u4eba\u5458\u8ba4\u4e3a\u8fd9\u63d0\u793a\u9700\u8981\u5f00\u5c55\u66f4\u591a\u7814\u7a76\u3002<\/p>\n<h2><span class=\"ez-toc-section\" id=\"05%E3%80%81Askbio%E3%80%81Prevail_Therapeutics%E5%92%8CCapsida_Biotherapeutics%E6%AD%A3%E5%9C%A8%E6%8E%A8%E8%BF%9B%E5%B8%95%E9%87%91%E6%A3%AE%E7%97%85%E5%9F%BA%E5%9B%A0%E7%96%97%E6%B3%95%E7%9A%84%E5%8F%91%E5%B1%95\"><\/span><strong>05\u3001Askbio\u3001Prevail Therapeutics\u548cCapsida Biotherapeutics\u6b63\u5728\u63a8\u8fdb\u5e15\u91d1\u68ee\u75c5\u57fa\u56e0\u7597\u6cd5\u7684\u53d1\u5c55<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>\u5c3d\u7ba1GLP-1\u5728\u6cbb\u7597\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u65b9\u9762\u7684\u4f5c\u7528\u5c1a\u4e0d\u660e\u786e\uff0c\u4f46\u57fa\u56e0\u7597\u6cd5\u548c\u5e72\u7ec6\u80de\u6cbb\u7597\u7b49\u518d\u751f\u533b\u5b66\u7b56\u7565\uff0c\u4f3c\u4e4e\u66f4\u9002\u5408\u7528\u4e8e\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\u3002Askbio\u516c\u53f8\u7684\u57fa\u56e0\u7597\u6cd5\u5019\u9009\u836f\u7269AB-1005\u7684\u4e34\u5e8a\u8bd5\u9a8c\u8fdb\u5c55\u987a\u5229\u3002\u8be5\u836f\u7269\u76ee\u524d\u6b63\u5728\u6ce2\u5170\u3001\u82f1\u56fd\u548c\u5fb7\u56fd\u8fdb\u884c\u4e8c\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u62db\u52df\u4e2d\u5ea6\u5e15\u91d1\u68ee\u75c5\u60a3\u8005\u3002<\/p>\n<p>\u80f6\u8d28\u7ec6\u80de\u7cfb\u884d\u751f\u795e\u7ecf\u8425\u517b\u56e0\u5b50\uff08GDNF\uff09\u57fa\u56e0\u2014\u2014\u4e00\u79cd\u6709\u52a9\u4e8e\u795e\u7ecf\u5143\u5b58\u6d3b\u7684\u86cb\u767d\u8d28\u2014\u2014\u901a\u8fc7\u817a\u76f8\u5173\u75c5\u6bd2\uff08AAV2\uff09\u8f7d\u4f53\u88ab\u9012\u9001\u5230\u5927\u8111\uff0c\u4ee5\u5e2e\u52a9\u4fdd\u62a4\u548c\u4fee\u590d\u4ea7\u751f\u591a\u5df4\u80fa\u7684\u795e\u7ecf\u5143\u3002\u4e00\u65e6\u8be5\u57fa\u56e0\u8fdb\u5165\u5927\u8111\uff0c\u8111\u7ec6\u80de\u5c31\u80fd\u6301\u7eed\u4ea7\u751fGDNF\uff0c\u4ece\u800c\u8fdb\u4e00\u6b65\u751f\u6210\u4ea7\u751f\u591a\u5df4\u80fa\u7684\u795e\u7ecf\u5143\u3002<\/p>\n<p>\u8fd9\u4e0e\u793c\u6765\u516c\u53f8\u65d7\u4e0b\u7684\u7f8e\u56fd\u751f\u7269\u6280\u672f\u516c\u53f8Prevail Therapeutics\u7684\u57fa\u56e0\u7597\u6cd5\u4ee5\u53ca\u52a0\u5ddeCapsida Biotherapeutics\u516c\u53f8\u7684CAP-003\u7684\u6cbb\u7597\u65b9\u6cd5\u4e0d\u540c\uff0c\u540e\u4e24\u8005\u5747\u9776\u5411<span class=\"\">GBA<\/span>\u57fa\u56e0\u7a81\u53d8\u3002GBA\u57fa\u56e0\u7a81\u53d8\u662f\u5e15\u91d1\u68ee\u75c5\u6700\u91cd\u8981\u7684\u9057\u4f20\u98ce\u9669\u56e0\u7d20\uff0c\u7ea65%\u81f315%\u7684\u5e15\u91d1\u68ee\u75c5\u60a3\u8005\u643a\u5e26\u8be5\u7a81\u53d8\u3002\u5b83\u4f1a\u5bfc\u81f4\u4e00\u79cd\u4e0e\u5e15\u91d1\u68ee\u75c5\u8fdb\u5c55\u548c\u795e\u7ecf\u9000\u884c\u6027\u53d8\u76f8\u5173\u7684\u9176\u7f3a\u4e4f\u3002Capsida\u516c\u53f8\u7684CAP-003\u4f7f\u7528\u7ecf\u8fc7\u57fa\u56e0\u6539\u9020\u7684AAV\u8863\u58f3\u5c06\u836f\u7269\u9012\u9001\u81f3\u5927\u8111\uff0c\u5e76\u4e8e\u4eca\u5e746\u6708\u83b7\u5f97\u4e86\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u7684IND\u6279\u51c6\u3002<\/p>\n<section>\n<div id=\"attachment_20383\" style=\"width: 1132px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-20383\" class=\"wp-image-20383 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-07_111735_238.png\" alt=\"\" width=\"1122\" height=\"337\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-07_111735_238.png 1122w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-07_111735_238-300x90.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-07_111735_238-1024x308.png 1024w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-07_111735_238-768x231.png 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-07_111735_238-18x5.png 18w\" sizes=\"(max-width: 1122px) 100vw, 1122px\" \/><p id=\"caption-attachment-20383\" class=\"wp-caption-text\">Capsida\u516c\u53f8\u7528\u4e8e\u6cbb\u7597GBA\u57fa\u56e0\u7a81\u53d8\u76f8\u5173\u5e15\u91d1\u68ee\u75c5\u7684\u9759\u8109\u6ce8\u5c04\u57fa\u56e0\u7597\u6cd5\u83b7\u5f97FDA IND\u6279\u51c6<\/p><\/div>\n<\/section>\n<p>\u4e0e\u6b64\u540c\u65f6\uff0c\u745e\u58eb\u5236\u836f\u5de8\u5934\u8bfa\u534e\u4e00\u76f4\u81f4\u529b\u4e8e\u7814\u53d1\u5e15\u91d1\u68ee\u75c5\u836f\u7269\u3002\u5c3d\u7ba1\u8bfa\u534e\u6b64\u524d\u4e0e\u4f18\u65f6\u6bd4\uff08<span class=\"\">UCB<\/span>\uff09\u7684\u5408\u4f5c\u8bd5\u9a8c\u4ee5\u5931\u8d25\u544a\u7ec8\uff0c\u4f46\u5b83\u5e76\u672a\u5c31\u6b64\u653e\u5f03\u3002<\/p>\n<p>\u4e0a\u4e2a\u6708\uff0c\u8bfa\u534e\u4e0e\u603b\u90e8\u4f4d\u4e8e\u52a0\u5dde\u7684Arrowhead Pharmaceuticals\u516c\u53f8\u8fbe\u6210\u4e86\u4e00\u9879\u4ef7\u503c2\u4ebf\u7f8e\u5143\u7684\u8bb8\u53ef\u534f\u8bae\uff0c\u65e8\u5728\u63a8\u52a8\u540e\u8005\u9488\u5bf9\u5e15\u91d1\u68ee\u75c5\u6807\u5fd7\u6027\u86cb\u767d\u03b1-\u7a81\u89e6\u6838\u86cb\u767d\u7684RNA\u9879\u76ee\u8fdb\u5165\u4e34\u5e8a\u8bd5\u9a8c\u9636\u6bb5\u3002\u8fd9\u9879\u4ef7\u503c\u9ad8\u8fbe20\u4ebf\u7f8e\u5143\u7684\u91cc\u7a0b\u7891\u4ed8\u6b3e\u534f\u8bae\u5c06\u6388\u4e88\u8bfa\u534e\u4e00\u79cd\u540d\u4e3aARO-SNCA\u7684\u5c0f\u5e72\u6270RNA\uff08siRNA\uff09\u7684\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u6743\u5229\u3002<\/p>\n<section>\n<div id=\"attachment_20382\" style=\"width: 953px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-20382\" class=\"wp-image-20382 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-07_112023_878.png\" alt=\"Arrowhead Pharmaceuticals\u4e0e\u8bfa\u534e\u8fbe\u6210\u5168\u7403\u8bb8\u53ef\u548c\u5408\u4f5c\u534f\u8bae\" width=\"943\" height=\"414\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-07_112023_878.png 943w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-07_112023_878-300x132.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-07_112023_878-768x337.png 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-07_112023_878-18x8.png 18w\" sizes=\"(max-width: 943px) 100vw, 943px\" \/><p id=\"caption-attachment-20382\" class=\"wp-caption-text\">Arrowhead Pharmaceuticals\u4e0e\u8bfa\u534e\u8fbe\u6210\u5168\u7403\u8bb8\u53ef\u548c\u5408\u4f5c\u534f\u8bae<\/p><\/div>\n<\/section>\n<section data-role=\"outer\" data-pm-slice=\"0 0 []\">\n<section data-role=\"paragraph\">\n<section data-role=\"list\" data-pm-slice=\"7 5 [&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;outer&quot;,&quot;label&quot;:&quot;edit by 135editor&quot;,&quot;data-pm-slice&quot;:&quot;0 0 []&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;paragraph&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;list&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;list&quot;,&quot;data-pm-slice&quot;:&quot;4 4 [\\&quot;para\\&quot;,{\\&quot;tagName\\&quot;:\\&quot;section\\&quot;,\\&quot;attributes\\&quot;:{\\&quot;data-role\\&quot;:\\&quot;outer\\&quot;,\\&quot;label\\&quot;:\\&quot;edit by 135editor\\&quot;,\\&quot;data-pm-slice\\&quot;:\\&quot;0 0 []\\&quot;},\\&quot;namespaceURI\\&quot;:\\&quot;http:\/\/www.w3.org\/1999\/xhtml\\&quot;},\\&quot;para\\&quot;,{\\&quot;tagName\\&quot;:\\&quot;section\\&quot;,\\&quot;attributes\\&quot;:{\\&quot;data-role\\&quot;:\\&quot;paragraph\\&quot;},\\&quot;namespaceURI\\&quot;:\\&quot;http:\/\/www.w3.org\/1999\/xhtml\\&quot;}]&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;outer&quot;,&quot;label&quot;:&quot;edit by 135editor&quot;,&quot;data-pm-slice&quot;:&quot;0 0 []&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;paragraph&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;}]\">\n<section data-role=\"list\" data-pm-slice=\"4 4 [&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;outer&quot;,&quot;label&quot;:&quot;edit by 135editor&quot;,&quot;data-pm-slice&quot;:&quot;0 0 []&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;paragraph&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;}]\">\n<h2><span class=\"ez-toc-section\" id=\"06%E3%80%81%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%EF%BC%9A%E4%BF%AE%E5%A4%8D%E5%8F%97%E6%8D%9F%E5%A4%A7%E8%84%91%E7%9A%84%E6%96%B0%E5%B8%8C%E6%9C%9B\"><\/span><strong>06\u3001\u5e72\u7ec6\u80de\u6cbb\u7597\uff1a\u4fee\u590d\u53d7\u635f\u5927\u8111\u7684\u65b0\u5e0c\u671b<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>\u5728\u63a2\u7d22\u75be\u75c5\u4fee\u9970\u7597\u6cd5\u7684\u591a\u79cd\u8def\u5f84\u4e2d\uff0c\u5e72\u7ec6\u80de\u6cbb\u7597\u4ee3\u8868\u4e86\u518d\u751f\u533b\u5b66\u7684\u524d\u6cbf\u3002\u8be5\u7b56\u7565\u7684\u6838\u5fc3\u5728\u4e8e\uff0c\u901a\u8fc7\u79fb\u690d\u5065\u5eb7\u7684\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u524d\u4f53\u7ec6\u80de\uff0c\u66ff\u4ee3\u5e15\u91d1\u68ee\u75c5\u60a3\u8005\u8111\u4e2d\u9000\u884c\u6027\u4e22\u5931\u7684\u795e\u7ecf\u5143\uff0c\u4ece\u800c\u5728\u6839\u672c\u4e0a\u6062\u590d\u591a\u5df4\u80fa\u7684\u5206\u6ccc\u4e0e\u8fd0\u52a8\u529f\u80fd\u7684\u8c03\u63a7\u3002<\/p>\n<p>\u76ee\u524d\uff0c\u591a\u9879\u91c7\u7528\u4eba\u591a\u80fd\u5e72\u7ec6\u80de\uff08\u5305\u62ec\u80da\u80ce\u5e72\u7ec6\u80de\u548c\u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80deiPSC\uff09\u5206\u5316\u6765\u6e90\u7684\u7ec6\u80de\u7597\u6cd5\u5df2\u8fdb\u5165\u4e34\u5e8a\u9636\u6bb5\u3002<\/p>\n<ul class=\"list-paddingleft-1\">\n<li><a class=\"normal_text_link mp_article_text_link\" href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzkwOTEzMDY0Nw==&amp;mid=2247513080&amp;idx=1&amp;sn=5328adeab2c2c20c9661a8d3a279b021&amp;scene=21#wechat_redirect\" target=\"_blank\" rel=\"noopener nofollow\" data-itemshowtype=\"0\" data-linktype=\"2\">\u5e7f\u5927\u5e15\u91d1\u68ee\u75c5\u60a3\u8005\u798f\u97f3\uff01\u5ba3\u6b66\u533b\u9662\uff1a\u81ea\u4f53\u8bf1\u5bfc\u795e\u7ecf\u5e72\u7ec6\u80de\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\u7684\u9996\u4f8b\u60a3\u8005\u83b7\u76ca<\/a><\/li>\n<li><a class=\"normal_text_link mp_article_text_link\" href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzkwOTEzMDY0Nw==&amp;mid=2247515002&amp;idx=1&amp;sn=72dd641178778a5861a0e29dd73ea901&amp;scene=21#wechat_redirect\" target=\"_blank\" rel=\"noopener nofollow\" data-itemshowtype=\"0\" data-linktype=\"2\">\u91cd\u78c5\uff01\u5e15\u91d1\u68ee\u75c5\u518d\u751f\u7597\u6cd5\u7a81\u7834\uff1ahESC\u884d\u751f\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u5728I\u671f\u8bd5\u9a8c\u5c55\u73b0\u5b89\u5168\u6027\u4e0e\u529f\u80fd\u6062\u590d\u6f5c\u529b<\/a><\/li>\n<li><a class=\"normal_text_link mp_article_text_link\" href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzkwOTEzMDY0Nw==&amp;mid=2247516844&amp;idx=1&amp;sn=2e6df8a67e9584180cd5774689336037&amp;scene=21#wechat_redirect\" target=\"_blank\" rel=\"noopener nofollow\" data-itemshowtype=\"0\" data-linktype=\"2\">\u7ec6\u80de\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\u8fce\u6765\u91cc\u7a0b\u7891\uff1a\u4eba\u80da\u80ce\u5e72\u7ec6\u80de\u7597\u6cd5\u5b89\u5168\u6709\u6548\uff0c\u957f\u671f\u968f\u8bbf\u8bc1\u5b9e\u8fd0\u52a8\u529f\u80fd\u663e\u8457\u63d0\u5347 | Cell\u91cd\u78c5<\/a><\/li>\n<\/ul>\n<p>\u4f8b\u5982\uff0c2023\u5e74\uff0c\u62dc\u8033\u65d7\u4e0b\u7684BlueRock Therapeutics\u516c\u53f8\u5f00\u53d1\u7684<span data-pm-slice=\"0 0 []\">bemdaneprocel\uff08BRT-DA01\uff09\u5728I\u671f\u4e34\u5e8a\u8bd5\u9a8c\u53d6\u5f97\u79ef\u6781\u7ed3\u679c\u7684\u8be6\u7ec6\u4fe1\u606f\u3002Bemdaneprocel\u662f\u4e00\u79cd\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\u7684\u5e72\u7ec6\u80de\u884d\u751f\u7597\u6cd5\u3002\u4e0a\u8ff0\u6570\u636e\u5df2\u5728\u4e39\u9ea6\u54e5\u672c\u54c8\u6839\u4e3e\u884c\u7684\u56fd\u9645\u5e15\u91d1\u68ee\u75c5\u548c\u8fd0\u52a8\u969c\u788d\u5927\u4f1a\u4e0a\u516c\u5e03\u3002<\/span><\/p>\n<section>\n<div id=\"attachment_20376\" style=\"width: 643px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-20376\" class=\"wp-image-20376 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-07_115157_236.png\" alt=\"\" width=\"633\" height=\"357\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-07_115157_236.png 633w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-07_115157_236-300x169.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-07_115157_236-18x10.png 18w\" sizes=\"(max-width: 633px) 100vw, 633px\" \/><p id=\"caption-attachment-20376\" class=\"wp-caption-text\">\u56fe\u6e90\uff1a\u62dc\u5c14\u4e2d\u56fd\u5b98\u7f51\u622a\u56fe<\/p><\/div>\n<\/section>\n<p><span data-pm-slice=\"0 0 []\">2025\u5e744\u6708\uff0c<a href=\"https:\/\/www.bluerocktx.com\/bluerock-therapeutics-announces-publication-in-nature-of-18-month-data-from-phase-1-clinical-trial-for-bemdaneprocel-an-investigational-cell-therapy-for-parkinsons-disease\/\" target=\"_blank\" rel=\"noopener nofollow\">BlueRock Therapeutics\u5ba3\u5e03\u5728\u300a\u81ea\u7136\u300b\u6742\u5fd7\u4e0a\u53d1\u8868\u4e86\u5176\u7528\u4e8e\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\u7684\u5728\u7814\u7ec6\u80de\u7597\u6cd5bemdaneprocel\u76841\u671f\u4e34\u5e8a\u8bd5\u9a8c\u768418\u4e2a\u6708\u6570\u636e<\/a>The<\/span><\/p>\n<section><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-20377 aligncenter\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-07_115026_941.png\" alt=\"\" width=\"1172\" height=\"309\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-07_115026_941.png 1172w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-07_115026_941-300x79.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-07_115026_941-1024x270.png 1024w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-07_115026_941-768x202.png 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-07_115026_941-18x5.png 18w\" sizes=\"(max-width: 1172px) 100vw, 1172px\" \/><\/section>\n<p><span data-pm-slice=\"0 0 []\"><span dir=\"auto\" data-pm-slice=\"0 0 []\">\u8be5\u8bba\u6587<\/span><span dir=\"auto\">\u8bc1\u5b9e\uff0c\u672f\u540e18\u4e2a\u6708\uff0c\u4f7f\u7528bemdaneprocel\u6cbb\u7597\u672a\u5f15\u8d77\u4efb\u4f55\u4e0e\u7ec6\u80de\u6cbb\u7597\u76f8\u5173\u7684\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\u3002\u6b64\u5916\uff0c\u6b63\u7535\u5b50\u53d1\u5c04\u65ad\u5c42\u626b\u63cf\uff08PET\uff09\u6210\u50cf\u6280\u672f\u663e\u793a\uff0c\u5728\u6cbb\u7597\u4e00\u5e74\u540e\u505c\u6b62\u514d\u75ab\u6291\u5236\u6cbb\u7597\u540e\uff0c\u8bd5\u9a8c\u7684\u9ad8\u5242\u91cf\u7ec4\u548c\u4f4e\u5242\u91cf\u7ec4\u4e2d\u5747\u89c2\u5bdf\u5230\u6301\u7eed\u7684\u795e\u7ecf\u5143\u7ec6\u80de\u690d\u5165\u3002\u8be5\u8bba\u6587\u8fd8\u62a5\u544a\u4e86\u4e0e\u8fd0\u52a8\u529f\u80fd\u76f8\u5173\u7684\u6b21\u8981\u7ec8\u70b9\u548c\u63a2\u7d22\u6027\u4e3b\u89c2\u53ca\u5ba2\u89c2\u7ec8\u70b9\u7684\u4ee4\u4eba\u9f13\u821e\u7684\u8d8b\u52bf\u3002<\/span><\/span><\/p>\n<p><b data-pm-slice=\"0 0 []\"><span data-contrast=\"auto\"><span dir=\"auto\">2025\u5e7410\u67087\u65e5<\/span><\/span><\/b><span data-contrast=\"auto\"><span dir=\"auto\">\u2014\u2014<a href=\"https:\/\/www.bluerocktx.com\/bluerock-therapeutics-reports-positive-36-month-results-from-phase-i-trial-of-bemdaneprocel-for-treating-parkinsons-disease\/\" target=\"_blank\" rel=\"noopener nofollow\">\u62dc\u8033\u516c\u53f8\u53ca\u5176\u5168\u8d44\u62e5\u6709\u5e76\u72ec\u7acb\u8fd0\u8425\u7684\u5b50\u516c\u53f8BlueRock Therapeutics LP\u516c\u5e03\u4e86\u5176\u5728\u7814\u7ec6\u80de\u7597\u6cd5bemdaneprocel\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\uff08PD\uff09\u7684I\u671f\u4e34\u5e8a\u8bd5\u9a8cexPDite\u768436\u4e2a\u6708\u79ef\u6781\u6570\u636e<\/a>The<\/span><\/span><\/section>\n<section data-role=\"list\" data-pm-slice=\"4 4 [&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;outer&quot;,&quot;label&quot;:&quot;edit by 135editor&quot;,&quot;data-pm-slice&quot;:&quot;0 0 []&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;paragraph&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;}]\"><span data-contrast=\"auto\"><span dir=\"auto\">\u00a0<\/span><\/span><\/section>\n<section><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-20378 aligncenter\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-07_114933_461.png\" alt=\"\" width=\"1160\" height=\"472\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-07_114933_461.png 1160w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-07_114933_461-300x122.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-07_114933_461-1024x417.png 1024w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-07_114933_461-768x312.png 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-07_114933_461-18x7.png 18w\" sizes=\"(max-width: 1160px) 100vw, 1160px\" \/><\/section>\n<section data-role=\"list\" data-pm-slice=\"4 4 [&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;outer&quot;,&quot;label&quot;:&quot;edit by 135editor&quot;,&quot;data-pm-slice&quot;:&quot;0 0 []&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;paragraph&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;}]\"><span data-contrast=\"auto\"><span dir=\"auto\">\u00a0<\/span><\/span><\/section>\n<section data-role=\"list\" data-pm-slice=\"4 4 [&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;outer&quot;,&quot;label&quot;:&quot;edit by 135editor&quot;,&quot;data-pm-slice&quot;:&quot;0 0 []&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;paragraph&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;}]\"><span data-contrast=\"auto\"><span dir=\"auto\">\u6700\u7ec8\u6570\u636e\u8868\u660eBemdaneprocel\u6cbb\u759736\u4e2a\u6708\u7684\u5b89\u5168\u6027\u4e0e\u4e4b\u524d\u7684\u7814\u7a76\u7ed3\u679c\u4e00\u81f4\uff0c\u8868\u660e\u60a3\u8005\u5bf9\u5176\u8010\u53d7\u6027\u826f\u597d\uff0c\u672a\u62a5\u544a\u4e0e\u6cbb\u7597\u6216\u624b\u672f\u76f8\u5173\u7684\u4efb\u4f55\u4e0d\u826f\u4e8b\u4ef6\u3002<\/span><\/span><\/section>\n<section data-role=\"list\" data-pm-slice=\"4 4 [&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;outer&quot;,&quot;label&quot;:&quot;edit by 135editor&quot;,&quot;data-pm-slice&quot;:&quot;0 0 []&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;paragraph&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;}]\"><\/section>\n<section data-role=\"list\" data-pm-slice=\"4 4 [&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;outer&quot;,&quot;label&quot;:&quot;edit by 135editor&quot;,&quot;data-pm-slice&quot;:&quot;0 0 []&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;paragraph&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;}]\">\u6839\u636e\u5e15\u91d1\u68ee\u75c5\u65e5\u8bb0\u7684\u8bc4\u4f30\u7ed3\u679c\uff0c\u5728\u4e3a\u671f36\u4e2a\u6708\u7684\u7814\u7a76\u4e2d\uff0c\u4e0d\u540c\u5242\u91cf\u7ec4\u5747\u663e\u793a\u51fa\u5bf9\u60a3\u8005\u8fd0\u52a8\u72b6\u6001\u7684\u6539\u5584\u3002\u9ad8\u5242\u91cf\u7ec4\u53c2\u4e0e\u8005\u7684\u201c\u826f\u597d\u5f00\u201d\u72b6\u6001\u65f6\u95f4\u5e73\u5747\u589e\u52a0\u4e861\u5c0f\u65f6\uff0c\u540c\u65f6\u201c\u5173\u201d\u72b6\u6001\u65f6\u95f4\u5e73\u5747\u51cf\u5c11\u4e860.93\u5c0f\u65f6\uff1b\u800c\u4f4e\u5242\u91cf\u7ec4\u7684\u6539\u5584\u5e45\u5ea6\u76f8\u5bf9\u8f83\u5c0f\uff0c\u201c\u826f\u597d\u5f00\u201d\u72b6\u6001\u65f6\u95f4\u4ec5\u5e73\u5747\u589e\u52a00.23\u5c0f\u65f6\uff0c\u4f46\u201c\u5173\u201d\u72b6\u6001\u65f6\u95f4\u51cf\u5c11\u66f4\u4e3a\u660e\u663e\uff0c\u8fbe1.15\u5c0f\u65f6\u3002\u9700\u8981\u8bf4\u660e\u7684\u662f\uff0c\u9ad8\u5242\u91cf\u7ec4\u4e2d\u6709\u4e24\u540d\u53c2\u4e0e\u8005\u672a\u63d0\u4ea4\u6700\u7ec8\u8bc4\u4f30\u6570\u636e\u3002<\/section>\n<p>\u8fdb\u4e00\u6b65\u901a\u8fc7MDS-UPDRS\u7b2c\u4e8c\u90e8\u5206\u8bc4\u4f30\u65e5\u5e38\u751f\u6d3b\u6d3b\u52a8\u80fd\u529b\u7684\u53d8\u5316\u53d1\u73b0\uff0c\u9ad8\u5242\u91cf\u7ec4\u572836\u4e2a\u6708\u540e\u8bc4\u5206\u5e73\u5747\u4e0b\u964d4.3\u5206\uff0c\u8868\u660e\u529f\u80fd\u5f97\u5230\u6539\u5584\uff1b\u800c\u4f4e\u5242\u91cf\u7ec4\u8bc4\u5206\u53cd\u800c\u5e73\u5747\u4e0a\u53470.2\u5206\uff0c\u63d0\u793a\u529f\u80fd\u7565\u6709\u6076\u5316\u3002\u4e24\u4e2a\u5242\u91cf\u7ec4\u7684\u53c2\u4e0e\u8005\u76ee\u524d\u90fd\u4ecd\u5728\u53c2\u4e0e\u957f\u671f\u968f\u8bbf\u7814\u7a76\uff0c\u4ee5\u8bc4\u4f30\u6cbb\u7597\u7684\u6301\u7eed\u6548\u679c\u3002<\/p>\n<p><span data-contrast=\"auto\"><span dir=\"auto\">\u8fd9\u9879I\u671f\u7814\u7a76\u768436\u4e2a\u6708\u6570\u636e\u8fdb\u4e00\u6b65\u5370\u8bc1\u4e86\u6211\u4eec\u7684\u5e0c\u671b\uff0c\u5373bemdaneprocel\u53ef\u80fd\u6210\u4e3a\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\u60a3\u8005\u4e00\u79cd\u6f5c\u5728\u6709\u6548\u4e14\u6301\u4e45\u7684\u6cbb\u7597\u9009\u62e9\u3002<\/span><\/span><\/p>\n<section data-role=\"list\" data-pm-slice=\"4 4 [&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;outer&quot;,&quot;label&quot;:&quot;edit by 135editor&quot;,&quot;data-pm-slice&quot;:&quot;0 0 []&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;paragraph&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;}]\">\u6b64\u5916\uff0c\u4eac\u90fd\u5927\u5b66\u7684iPS\u7ec6\u80de\u7814\u7a76\u9879\u76ee\u4e5f\u6b63\u81f4\u529b\u4e8e\u63a8\u52a8\u65e0\u9700\u514d\u75ab\u6291\u5236\u7684\u201c\u73b0\u8d27\u578b\u201d\u7ec6\u80de\u7597\u6cd5\u8fdb\u5165\u4e34\u5e8a\u3002<\/p>\n<p>\u65e9\u671f\u7684\u4e34\u5e8a\u524d\u4e0e\u975e\u4eba\u7075\u957f\u7c7b\u7814\u7a76\u663e\u793a\uff0c\u79fb\u690d\u7684\u7ec6\u80de\u80fd\u591f\u5728\u5bbf\u4e3b\u8111\u5185\u5b58\u6d3b\u3001\u6574\u5408\uff0c\u5e76\u6709\u6548\u6539\u5584\u8fd0\u52a8\u75c7\u72b6\u3002\u5c3d\u7ba1\u5728\u7ec6\u80de\u7eaf\u5ea6\u3001\u79fb\u690d\u6280\u672f\u53ca\u53ef\u80fd\u6d89\u53ca\u7684\u514d\u75ab\u6392\u65a5\u65b9\u9762\u4ecd\u9700\u4f18\u5316\uff0c\u5e72\u7ec6\u80de\u7597\u6cd5\u65e0\u7591\u4e3a\u9006\u8f6c\u75be\u75c5\u8fdb\u7a0b\u5e26\u6765\u4e86\u524d\u6240\u672a\u6709\u7684\u6f5c\u529b\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<h2><span class=\"ez-toc-section\" id=\"07%E3%80%81RNA%E5%B9%B2%E6%89%B0%E6%98%AF%E8%A7%A3%E5%86%B3%E9%97%AE%E9%A2%98%E7%9A%84%E6%AD%A3%E7%A1%AE%E6%96%B9%E6%B3%95%E5%90%97%EF%BC%9F\"><\/span><strong>07\u3001RNA\u5e72\u6270\u662f\u89e3\u51b3\u95ee\u9898\u7684\u6b63\u786e\u65b9\u6cd5\u5417\uff1f<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>siRNA\u662fRNA\u5e72\u6270\u8fc7\u7a0b\u4e2d\u7684\u5173\u952e\u7ec4\u6210\u90e8\u5206\uff0c\u8be5\u8fc7\u7a0b\u5229\u7528RNA\u5206\u5b50\u9776\u5411\u5176\u4ed6RNA\uff08\u79f0\u4e3a\u4fe1\u4f7fRNA\uff0cmRNA\uff09\u6765\u6c89\u9ed8\u57fa\u56e0\u3002Arrowhead\u516c\u53f8\u7684siRNA\u65e8\u5728\u89e6\u53d1\u8fd9\u4e00\u673a\u5236\uff0c\u4ece\u800c\u7279\u5f02\u6027\u5730\u5173\u95ed\u5e15\u91d1\u68ee\u75c5\u60a3\u8005\u4f53\u5185\u7f16\u7801\u03b1-\u7a81\u89e6\u6838\u86cb\u767d\u7684\u57fa\u56e0\u3002<\/p>\n<p>\u867d\u7136\u8fd9\u4e24\u5bb6\u516c\u53f8\u5c1a\u672a\u900f\u9732ARO-SNCA\u7814\u53d1\u7684\u5b8c\u6574\u65f6\u95f4\u8868\uff0c\u4f46\u8fc7\u53bb\u66fe\u5f15\u8d77\u6b66\u7530\u3001\u845b\u5170\u7d20\u53f2\u514b\u548c\u8d5b\u8bfa\u83f2\u7b49\u5927\u578b\u5236\u836f\u516c\u53f8\u5173\u6ce8\u7684Arrowhead\u516c\u53f8\u5ba3\u5e03\uff0c\u8be5\u836f\u7269\u5c06\u5c3d\u5feb\u8fdb\u5165\u4e34\u5e8a\u8bd5\u9a8c\u9636\u6bb5\u3002<\/p>\n<p>\u53e6\u4e00\u9879\u6709\u671b\u5c06\u5e15\u91d1\u68ee\u75c5\u7597\u6cd5\u63a8\u5411\u4e34\u5e8a\u7684\u5408\u4f5c\u534f\u8bae\u7531\u6bd4\u5229\u65f6\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u6cbb\u7597\u516c\u53f8Clouds of Care\u548c\u745e\u58eb\u7814\u7a76\u516c\u53f8Indivi\u8fbe\u6210\u3002\u53cc\u65b9\u81f4\u529b\u4e8e\u63a8\u8fdb\u7cbe\u51c6\u533b\u7597\uff0c\u5c06\u7ed3\u5408\u795e\u7ecf\u7535\u751f\u7406\u5b66\u548c\u6570\u5b57\u5065\u5eb7\u6280\u672f\u5de5\u5177\uff0c\u7814\u53d1\u4e00\u79cd\u9488\u5bf9\u5e15\u91d1\u68ee\u75c5\u60a3\u8005\u8ba4\u77e5\u548c\u8fd0\u52a8\u884c\u4e3a\u7684\u7597\u6cd5\u3002<\/p>\n<p>\u5c3d\u7ba1\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u9886\u57df\u662f\u533b\u5b66\u754c\u6700\u4e25\u5cfb\u7684\u6311\u6218\u4e4b\u4e00\uff0c\u6280\u672f\u548c\u76d1\u7ba1\u65b9\u9762\u7684\u6210\u529f\u6982\u7387\u5386\u6765\u5f88\u4f4e\uff0c\u4f46\u4ea4\u6613\u64ae\u5408\u8005\u4ecd\u7136\u62b1\u6709\u5f88\u9ad8\u7684\u671f\u671b\u3002<\/p>\n<p>\u201c\u5e74\u9f84\u662f\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u7684\u4e3b\u8981\u98ce\u9669\u56e0\u7d20\uff0c\u6211\u4eec\u6b63\u9762\u4e34\u4e00\u573a\u5168\u7403\u6027\u6d41\u884c\u75c5\uff0c\u201dClouds of Care\u8463\u4e8b\u4f1a\u4e3b\u5e2d\u7c73\u6b47\u5c14\u00b7\u6c83\u7eb3\u7279\u7d22\u65af\uff08Michel Vounatsos\uff09\u5728\u4e00\u4efd\u65b0\u95fb\u7a3f\u4e2d\u8868\u793a\u3002\u201c\u6df1\u5ea6\u8868\u578b\u5206\u6790\u6280\u672f\u5bf9\u4e8e\u63d0\u9ad8\u963f\u5c14\u8328\u6d77\u9ed8\u6c0f\u75c7\u548c\u5e15\u91d1\u68ee\u6c0f\u75c7\u7684\u836f\u7269\u5f00\u53d1\u6210\u529f\u7387\u4ee5\u53ca\u5ef6\u957f\u5065\u5eb7\u5927\u8111\u7684\u6574\u4e2a\u751f\u547d\u5468\u671f\u81f3\u5173\u91cd\u8981\u3002\u201d<\/p>\n<section>\n<div id=\"attachment_20381\" style=\"width: 889px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-20381\" class=\"wp-image-20381 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-07_112623_925.png\" alt=\"\" width=\"879\" height=\"193\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-07_112623_925.png 879w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-07_112623_925-300x66.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-07_112623_925-768x169.png 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-07_112623_925-18x4.png 18w\" sizes=\"(max-width: 879px) 100vw, 879px\" \/><p id=\"caption-attachment-20381\" class=\"wp-caption-text\">Indivi\u4e0eClouds of Care\u5408\u4f5c\uff0c\u63a8\u8fdb\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u548c\u5e15\u91d1\u68ee\u75c5\u65e9\u671f\u836f\u7269\u7814\u53d1\u4e2d\u7684\u6df1\u5ea6\u8868\u578b\u5206\u6790<\/p><\/div>\n<\/section>\n<h2><span class=\"ez-toc-section\" id=\"08%E3%80%81%E5%B8%95%E9%87%91%E6%A3%AE%E7%97%85%EF%BC%9A%E7%BD%97%E6%B0%8F%E5%8D%95%E5%85%8B%E9%9A%86%E6%8A%97%E4%BD%93prasinezumab%E5%85%8B%E6%9C%8D%E6%8C%AB%E6%8A%98\"><\/span><strong>08\u3001\u5e15\u91d1\u68ee\u75c5\uff1a\u7f57\u6c0f\u5355\u514b\u9686\u6297\u4f53prasinezumab\u514b\u670d\u632b\u6298<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>\u7531\u4e8e\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u7814\u7a76\u662f\u70ed\u95e8\u8bdd\u9898\uff0c\u8bb8\u591a\u4eba\u90fd\u5728\u7b49\u5f85FDA\u5bf9tavapadon\u7684\u51b3\u5b9a\u3002\u4e0e\u6b64\u540c\u65f6\uff0c\u7d27\u968f\u5176\u540e\u7684\u662f\u745e\u58eb\u5236\u836f\u5de8\u5934\u7f57\u6c0f\u7684\u5355\u514b\u9686\u6297\u4f53\u836f\u7269prasinezumab\uff0c\u8be5\u836f\u7269\u76ee\u524d\u5904\u4e8e3\u671f\u4e34\u5e8a\u8bd5\u9a8c\u9636\u6bb5\uff0c\u4f46\u8fdb\u5c55\u5e76\u4e0d\u987a\u5229\u3002<\/p>\n<p>\u4e0e\u5176\u4ed6\u8bb8\u591a\u7597\u6cd5\u4e00\u6837\uff0cprasinezumab\u4e5f\u9776\u5411\u805a\u96c6\u7684\u03b1-\u7a81\u89e6\u6838\u86cb\u767d\u7c07\uff0c\u4f46\u5b83\u662f\u901a\u8fc7\u4e0e\u8fd9\u4e9b\u86cb\u767d\u7ed3\u5408\u6765\u964d\u4f4e\u6bd2\u6027\u7684\u3002\u53bb\u5e74\uff0c\u4e00\u98792b\u671f\u4e34\u5e8a\u8bd5\u9a8c\u672a\u80fd\u8fbe\u5230\u7ec8\u70b9\uff0c\u5373\u60a3\u8005\u8fd0\u52a8\u529f\u80fd\u4e0b\u964d\u6240\u9700\u7684\u65f6\u95f4\u3002\u4f46\u7531\u4e8e\u8be5\u836f\u7269\u5df2\u663e\u793a\u51fa\u7597\u6548\uff0c\u76ee\u524d\u4ecd\u5728\u8fdb\u884c\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5df2\u6709\u8d85\u8fc7750\u540d\u65e9\u671f\u5e15\u91d1\u68ee\u75c5\u60a3\u8005\u53c2\u4e0e\u5176\u4e2d\u3002<\/p>\n<section>\n<div id=\"attachment_20380\" style=\"width: 1440px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-20380\" class=\"wp-image-20380 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-07_112902_048.png\" alt=\"\" width=\"1430\" height=\"598\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-07_112902_048.png 1430w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-07_112902_048-300x125.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-07_112902_048-1024x428.png 1024w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-07_112902_048-768x321.png 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-07_112902_048-18x8.png 18w\" sizes=\"(max-width: 1430px) 100vw, 1430px\" \/><p id=\"caption-attachment-20380\" class=\"wp-caption-text\">\u7f57\u6c0f\u516c\u53f8\u666e\u62c9\u897f\u73e0\u5355\u6297\u7684IIb\u671f\u7814\u7a76\u672a\u80fd\u8fbe\u5230\u4e3b\u8981\u7ec8\u70b9\uff0c\u4f46\u63d0\u793a\u8be5\u836f\u7269\u53ef\u80fd\u5bf9\u65e9\u671f\u5e15\u91d1\u68ee\u75c5\u60a3\u8005\u6709\u76ca<\/p><\/div>\n<\/section>\n<h2><span class=\"ez-toc-section\" id=\"%E6%80%BB%E7%BB%93\"><\/span><strong>\u603b\u7ed3<\/strong><span 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