{"id":20408,"date":"2025-11-12T14:45:56","date_gmt":"2025-11-12T06:45:56","guid":{"rendered":"https:\/\/www.hjtdsm.cn\/?p=20408"},"modified":"2025-11-12T14:45:56","modified_gmt":"2025-11-12T06:45:56","slug":"%e8%84%91%e7%a5%9e%e7%bb%8f%e5%b9%b2%e7%bb%86%e8%83%9e","status":"publish","type":"post","link":"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/nsc\/20408.html","title":{"rendered":"\u8111\u795e\u7ecf\u5e72\u7ec6\u80de\u7684\u751f\u7269\u5b66\u57fa\u7840\u4e0e\u518d\u751f\u533b\u5b66\u6f5c\u80fd\uff1a\u4ece\u795e\u7ecf\u53d1\u751f\u5230\u4e34\u5e8a\u7597\u6cd5"},"content":{"rendered":"<blockquote>\n<p data-start=\"79\" data-end=\"99\">\u8111\u795e\u7ecf\u5e72\u7ec6\u80de\uff08NSCs\uff09\u88ab\u5b9a\u4e49\u4e3a\u65e9\u671f\u795e\u7ecf\u4e0a\u76ae\u7ec4\u7ec7\u4e2d\u5177\u6709\u81ea\u6211\u66f4\u65b0\u80fd\u529b\u4e14\u80fd\u5206\u5316\u4e3a\u591a\u7c7b\u795e\u7ecf\u5143\u540e\u4ee3\u7684\u7ec6\u80de\uff0c\u53ef\u751f\u6210\u795e\u7ecf\u5143\u3001\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u548c\u5c11\u7a81\u80f6\u8d28\u7ec6\u80de\u3002\u8fd9\u7c7b\u7ec6\u80de\u4e3b\u8981\u5b58\u5728\u4e8e\u53d1\u80b2\u4e2d\u7684\u5927\u8111\u4e2d\uff0c\u5728\u6210\u5e74\u5927\u8111\u7684\u8111\u5ba4\u4e0b\u533a\u548c\u6d77\u9a6c\u533a\u4e5f\u6709\u5c11\u91cf\u5206\u5e03\uff0c\u53ef\u5728\u4f53\u5916\u8fdb\u884c\u5206\u79bb\u4e0e\u6269\u589e\u3002<\/p>\n<\/blockquote>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_79_2 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewbox=\"0 0 24 24\" version=\"1.2\" baseprofile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/nsc\/20408.html\/#%E4%B8%80%E3%80%81%E7%A5%9E%E7%BB%8F%E7%A7%91%E5%AD%A6%E4%B8%AD%E7%9A%84%E7%A5%9E%E7%BB%8F%E5%B9%B2%E7%BB%86%E8%83%9E%E7%AE%80%E4%BB%8B\" >\u4e00\u3001\u795e\u7ecf\u79d1\u5b66\u4e2d\u7684\u795e\u7ecf\u5e72\u7ec6\u80de\u7b80\u4ecb<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/nsc\/20408.html\/#%E4%BA%8C%E3%80%81%E8%84%91%E7%A5%9E%E7%BB%8F%E5%B9%B2%E7%BB%86%E8%83%9E%E7%9A%84%E7%94%9F%E7%89%A9%E5%AD%A6%E7%89%B9%E5%BE%81%E4%B8%8E%E8%B0%83%E6%8E%A7%E6%9C%BA%E5%88%B6\" >\u4e8c\u3001\u8111\u795e\u7ecf\u5e72\u7ec6\u80de\u7684\u751f\u7269\u5b66\u7279\u5f81\u4e0e\u8c03\u63a7\u673a\u5236<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/nsc\/20408.html\/#%E4%B8%89%E3%80%81%E7%A5%9E%E7%BB%8F%E5%B9%B2%E7%BB%86%E8%83%9E%E5%9C%A8%E7%A5%9E%E7%BB%8F%E5%8F%91%E7%94%9F%E3%80%81%E8%84%91%E5%8F%91%E8%82%B2%E4%B8%8E%E5%8F%AF%E5%A1%91%E6%80%A7%E4%B8%AD%E7%9A%84%E4%BD%9C%E7%94%A8\" >\u4e09\u3001\u795e\u7ecf\u5e72\u7ec6\u80de\u5728\u795e\u7ecf\u53d1\u751f\u3001\u8111\u53d1\u80b2\u4e0e\u53ef\u5851\u6027\u4e2d\u7684\u4f5c\u7528<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/nsc\/20408.html\/#%E5%9B%9B%E3%80%81%E7%A5%9E%E7%BB%8F%E5%B9%B2%E7%BB%86%E8%83%9E%E5%9C%A8%E7%A5%9E%E7%BB%8F%E7%B3%BB%E7%BB%9F%E7%96%BE%E7%97%85%E4%B8%8E%E6%8D%9F%E4%BC%A4%E4%B8%AD%E7%9A%84%E4%BD%9C%E7%94%A8\" >\u56db\u3001\u795e\u7ecf\u5e72\u7ec6\u80de\u5728\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u4e0e\u635f\u4f24\u4e2d\u7684\u4f5c\u7528<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/nsc\/20408.html\/#%E4%BA%94%E3%80%81%E7%A5%9E%E7%BB%8F%E5%B9%B2%E7%BB%86%E8%83%9E%E7%9A%84%E6%B2%BB%E7%96%97%E5%BA%94%E7%94%A8%E3%80%81%E6%8C%91%E6%88%98%E4%B8%8E%E6%9C%AA%E6%9D%A5%E6%96%B9%E5%90%91\" >\u4e94\u3001\u795e\u7ecf\u5e72\u7ec6\u80de\u7684\u6cbb\u7597\u5e94\u7528\u3001\u6311\u6218\u4e0e\u672a\u6765\u65b9\u5411<\/a><\/li><\/ul><\/nav><\/div>\n<h2 data-start=\"79\" data-end=\"99\"><span class=\"ez-toc-section\" id=\"%E4%B8%80%E3%80%81%E7%A5%9E%E7%BB%8F%E7%A7%91%E5%AD%A6%E4%B8%AD%E7%9A%84%E7%A5%9E%E7%BB%8F%E5%B9%B2%E7%BB%86%E8%83%9E%E7%AE%80%E4%BB%8B\"><\/span>\u4e00\u3001\u795e\u7ecf\u79d1\u5b66\u4e2d\u7684\u795e\u7ecf\u5e72\u7ec6\u80de\u7b80\u4ecb<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p data-start=\"101\" data-end=\"270\"><strong data-start=\"101\" data-end=\"168\">\u795e\u7ecf\u5e72\u7ec6\u80de\uff08Neural Stem Cells, NSCs\uff09\u5177\u6709\u4e24\u4e2a\u6838\u5fc3\u7279\u5f81\uff1a\u65e0\u9650\u7684\u81ea\u6211\u66f4\u65b0\u80fd\u529b\u548c\u591a\u5411\u5206\u5316\u6f5c\u80fd<\/strong>\uff0c\u5373\u80fd\u591f\u5206\u5316\u4e3a\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\uff08CNS\uff09\u7684\u4e09\u79cd\u4e3b\u8981\u7ec6\u80de\u7c7b\u578b\u2014\u2014\u795e\u7ecf\u5143\u3001\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u548c\u5c11\u7a81\u80f6\u8d28\u7ec6\u80de\u3002\u795e\u7ecf\u5e72\u7ec6\u80de\u662f\u795e\u7ecf\u7cfb\u7edf\u4e2d\u5206\u5316\u7a0b\u5ea6\u6700\u4f4e\u7684\u7ec6\u80de\uff0c\u7531\u4e8e\u7f3a\u4e4f\u8db3\u591f\u7279\u5f02\u7684\u514d\u75ab\u7ec6\u80de\u5316\u5b66\u6807\u8bb0\uff0c\u56e0\u6b64\u4e3b\u8981\u901a\u8fc7\u529f\u80fd\u7279\u5f81\u6765\u5b9a\u4e49\u3002<\/p>\n<p data-start=\"272\" data-end=\"408\"><a href=\"https:\/\/www.sciencedirect.com\/topics\/neuroscience\/neural-stem-cell\" target=\"_blank\" rel=\"noopener nofollow\">20\u4e16\u7eaa80\u5e74\u4ee3\u672b\u81f390\u5e74\u4ee3\u521d\uff0c\u79d1\u5b66\u5bb6\u5728\u556e\u9f7f\u7c7b\u52a8\u7269\u8111\u5185\u53d1\u73b0\u4e86\u6210\u4f53\u795e\u7ecf\u5e72\u7ec6\u80de\uff0c\u968f\u540e\u53c8\u5728\u6210\u4eba\u5927\u8111\u4e2d\u5f97\u5230\u8bc1\u5b9e<\/a>\uff0c\u8fd9\u4e00\u53d1\u73b0\u63a8\u7ffb\u4e86\u201c\u795e\u7ecf\u53d1\u751f\u5728\u53d1\u80b2\u5b8c\u6210\u540e\u7ec8\u6b62\u201d\u7684\u957f\u671f\u6559\u6761\u3002\u795e\u7ecf\u5e72\u7ec6\u80de\u5728\u6574\u4e2a\u751f\u547d\u8fc7\u7a0b\u4e2d\u6301\u7eed\u5b58\u5728\u4e8e\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u4e2d\uff0c\u901a\u8fc7\u4e0d\u65ad\u4ea7\u751f\u65b0\u7684\u795e\u7ecf\u5143\u548c\u795e\u7ecf\u80f6\u8d28\u7ec6\u80de\uff0c\u53c2\u4e0e\u8111\u7684\u53d1\u80b2\u4e0e\u7ef4\u6301\u3002<\/p>\n<p data-start=\"410\" data-end=\"507\">\u5728\u53d1\u80b2\u4e2d\u53ca\u6210\u4f53\u54fa\u4e73\u52a8\u7269\u7684\u5927\u8111\u4e2d\uff0c<a href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/nsc\/20338.html\/\" target=\"_blank\" rel=\"noopener\">neural stem cell<\/a>\u4f4d\u4e8e\u79f0\u4e3a\u795e\u7ecf\u53d1\u751f\u5fae\u73af\u5883\uff08neurogenic niche\uff09\u7684\u7279\u6b8a\u533a\u57df\u4e2d\uff0c\u8fd9\u4e9b\u5fae\u73af\u5883\u8c03\u63a7\u7740\u5e72\u7ec6\u80de\u7684\u589e\u6b96\u3001\u5206\u5316\u548c\u7ef4\u6301\u3002\u4e24\u4e2a\u4e3b\u8981\u7684\u795e\u7ecf\u53d1\u751f\u533a\u5305\u62ec\uff1a<\/p>\n<ul data-start=\"508\" data-end=\"564\">\n<li data-start=\"508\" data-end=\"534\">\n<p data-start=\"510\" data-end=\"534\"><strong data-start=\"510\" data-end=\"524\">\u4fa7\u8111\u5ba4\u4e0b\u533a\uff08SVZ\uff09<\/strong>\uff1a\u4f4d\u4e8e\u4fa7\u8111\u5ba4\u58c1\uff1b<\/p>\n<\/li>\n<li data-start=\"535\" data-end=\"564\">\n<p data-start=\"537\" data-end=\"564\"><strong data-start=\"537\" data-end=\"555\">\u6d77\u9a6c\u9f7f\u72b6\u56de\u4e0b\u9897\u7c92\u533a\uff08SGZ\uff09<\/strong>\uff1a\u4f4d\u4e8e\u6d77\u9a6c\u4f53\u3002<\/p>\n<\/li>\n<\/ul>\n<p data-start=\"566\" data-end=\"705\">\u6b64\u5916\uff0c\u7814\u7a76\u8fd8\u53d1\u73b0\u4e0b\u4e18\u8111\u7b49\u533a\u57df\u4e5f\u5b58\u5728\u6f5c\u5728\u7684\u795e\u7ecf\u53d1\u751f\u201c\u751f\u6001\u4f4d\u201d\u3002\u8fd9\u4e9b\u533a\u57df\u4e3a\u795e\u7ecf\u5e72\u7ec6\u80de\u63d0\u4f9b\u4e86\u6709\u5229\u7684\u5fae\u73af\u5883\uff0c\u652f\u6301\u5176\u81ea\u6211\u66f4\u65b0\u53ca\u5411\u795e\u7ecf\u5143\u3001\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u4e43\u81f3\u5c11\u7a81\u80f6\u8d28\u7ec6\u80de\u7684\u5206\u5316\u3002\u795e\u7ecf\u5e72\u7ec6\u80de\u5728\u795e\u7ecf\u53d1\u751f\u4e2d\u53d1\u6325\u6838\u5fc3\u4f5c\u7528\uff0c\u5176\u4ea7\u751f\u65b0\u795e\u7ecf\u7ec6\u80de\u7684\u80fd\u529b\u6b63\u662f\u5176\u5728\u518d\u751f\u533b\u5b66\u53ca\u795e\u7ecf\u75be\u75c5\u6cbb\u7597\u4e2d\u5177\u6709\u91cd\u8981\u610f\u4e49\u7684\u57fa\u7840\u3002<\/p>\n<p data-start=\"566\" data-end=\"705\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-20409 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/istockphoto-852110316-612x612-1.jpg\" alt=\"\u8111\u795e\u7ecf\u5e72\u7ec6\u80de\" width=\"612\" height=\"344\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/istockphoto-852110316-612x612-1.jpg 612w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/istockphoto-852110316-612x612-1-300x169.jpg 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/istockphoto-852110316-612x612-1-18x10.jpg 18w\" sizes=\"(max-width: 612px) 100vw, 612px\" \/><\/p>\n<hr data-start=\"707\" data-end=\"710\" \/>\n<h2 data-start=\"712\" data-end=\"735\"><span class=\"ez-toc-section\" id=\"%E4%BA%8C%E3%80%81%E8%84%91%E7%A5%9E%E7%BB%8F%E5%B9%B2%E7%BB%86%E8%83%9E%E7%9A%84%E7%94%9F%E7%89%A9%E5%AD%A6%E7%89%B9%E5%BE%81%E4%B8%8E%E8%B0%83%E6%8E%A7%E6%9C%BA%E5%88%B6\"><\/span>\u4e8c\u3001\u8111\u795e\u7ecf\u5e72\u7ec6\u80de\u7684\u751f\u7269\u5b66\u7279\u5f81\u4e0e\u8c03\u63a7\u673a\u5236<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p data-start=\"737\" data-end=\"864\">\u795e\u7ecf\u5e72\u7ec6\u80de\u8d77\u6e90\u4e8e\u795e\u7ecf\u677f\u4e2d\u7684<strong data-start=\"750\" data-end=\"783\">\u795e\u7ecf\u4e0a\u76ae\u7ec6\u80de\uff08neuroepithelial cells\uff09<\/strong>\uff0c\u8fd9\u4e9b\u7ec6\u80de\u901a\u8fc7\u5bf9\u79f0\u5206\u88c2\u6269\u589e\u540e\uff0c\u9010\u6e10\u8f6c\u5316\u4e3a<strong data-start=\"803\" data-end=\"827\">\u653e\u5c04\u72b6\u80f6\u8d28\u7ec6\u80de\uff08radial glia\uff09<\/strong>\u3002\u653e\u5c04\u72b6\u80f6\u8d28\u7ec6\u80de\u662f\u771f\u6b63\u7684\u795e\u7ecf\u5e72\u7ec6\u80de\uff0c\u5728\u4f53\u5185\u53ef\u751f\u6210\u795e\u7ecf\u5143\u548c\u795e\u7ecf\u80f6\u8d28\u7ec6\u80de\u3002<\/p>\n<p data-start=\"866\" data-end=\"997\">\u795e\u7ecf\u5e72\u7ec6\u80de\u7684\u4e24\u4e2a\u6838\u5fc3\u5c5e\u6027\u662f<strong data-start=\"879\" data-end=\"889\">\u65e0\u9650\u81ea\u6211\u66f4\u65b0<\/strong>respond in singing<strong data-start=\"890\" data-end=\"900\">\u591a\u5411\u5206\u5316\u6f5c\u80fd<\/strong>\uff0c\u80fd\u591f\u4ea7\u751f\u5305\u62ec\u795e\u7ecf\u5143\u3001\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u548c\u5c11\u7a81\u80f6\u8d28\u7ec6\u80de\u5728\u5185\u7684\u5168\u90e8\u4e3b\u8981\u795e\u7ecf\u8c31\u7cfb\u3002\u4e0e\u5176\u540e\u4ee3\u2014\u2014**\u7956\u7ec6\u80de\uff08progenitors\uff09**\u7684\u533a\u522b\u5728\u4e8e\uff1a\u7956\u7ec6\u80de\u7684\u5206\u5316\u6f5c\u80fd\u66f4\u53d7\u9650\uff0c\u800c\u795e\u7ecf\u5e72\u7ec6\u80de\u5177\u5907\u8f83\u5f3a\u7684\u53ef\u5851\u6027\u3002<\/p>\n<p data-start=\"999\" data-end=\"1028\">\u5728\u53d1\u80b2\u8fc7\u7a0b\u4e2d\uff0c\u795e\u7ecf\u5e72\u7ec6\u80de\u7ecf\u5386<strong data-start=\"1013\" data-end=\"1025\">\u5bf9\u79f0\u4e0e\u975e\u5bf9\u79f0\u5206\u88c2<\/strong>::<\/p>\n<ul data-start=\"1029\" data-end=\"1084\">\n<li data-start=\"1029\" data-end=\"1045\">\n<p data-start=\"1031\" data-end=\"1045\">\u5bf9\u79f0\u5206\u88c2\u53ef\u6269\u5927\u5e72\u7ec6\u80de\u5e93\uff1b<\/p>\n<\/li>\n<li data-start=\"1046\" data-end=\"1084\">\n<p data-start=\"1048\" data-end=\"1084\">\u975e\u5bf9\u79f0\u5206\u88c2\u5219\u4ea7\u751f\u4e00\u4e2a\u5e72\u7ec6\u80de\u4e0e\u4e00\u4e2a\u5206\u5316\u7684\u7956\u7ec6\u80de\uff0c\u8fdb\u800c\u4fc3\u8fdb\u795e\u7ecf\u5143\u591a\u6837\u6027\u3002<\/p>\n<\/li>\n<\/ul>\n<p data-start=\"1086\" data-end=\"1150\">\u5728\u6210\u4f53\u8111\u4e2d\uff0c\u795e\u7ecf\u5e72\u7ec6\u80de\u4e3b\u8981\u4f4d\u4e8e<strong data-start=\"1101\" data-end=\"1134\">\u4fa7\u8111\u5ba4\u4e0b\u533a\uff08SVZ\uff09\u4e0e\u6d77\u9a6c\u9f7f\u72b6\u56de\u4e0b\u9897\u7c92\u533a\uff08SGZ\uff09<\/strong>\uff0c\u5e76\u80fd\u5728\u6574\u4e2a\u6210\u5e74\u671f\u6301\u7eed\u5b58\u5728\u3002<\/p>\n<p data-start=\"1152\" data-end=\"1171\">\u8bc6\u522b\u795e\u7ecf\u5e72\u7ec6\u80de\u5e38\u7528\u7684\u5206\u5b50\u6807\u5fd7\u5305\u62ec\uff1a<\/p>\n<ul>\n<li data-start=\"1174\" data-end=\"1186\"><strong data-start=\"1174\" data-end=\"1184\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5185\u65af\u5ef7<\/span><\/span><\/strong><\/li>\n<li data-start=\"1174\" data-end=\"1186\"><strong data-start=\"1189\" data-end=\"1197\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">Sox2<\/span><\/span><\/strong><\/li>\n<li data-start=\"1174\" data-end=\"1186\"><strong data-start=\"1202\" data-end=\"1214\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6b66\u85cf1<\/span><\/span><\/strong><\/li>\n<\/ul>\n<p data-start=\"1202\" data-end=\"1252\">\u4f46\u8fd9\u4e9b\u6807\u5fd7\u5e76\u975e\u795e\u7ecf\u5e72\u7ec6\u80de\u6240\u72ec\u6709\uff0c\u4e5f\u53ef\u5728\u7956\u7ec6\u80de\u6216\u6210\u719f\u795e\u7ecf\u7ec6\u80de\u4e2d\u8868\u8fbe\u3002<\/p>\n<p data-start=\"1254\" data-end=\"1298\">\u795e\u7ecf\u5e72\u7ec6\u80de\u53ca\u5176\u540e\u4ee3\u5448\u73b0\u51fa\u660e\u663e\u7684\u5f02\u8d28\u6027\uff0c\u4e0d\u540c\u533a\u57df\u7684\u7ec6\u80de\u7fa4\u5177\u6709\u72ec\u7279\u7684\u5206\u5b50\u7279\u5f81\u548c\u529f\u80fd\u6807\u8bb0\u3002<\/p>\n<p data-start=\"1300\" data-end=\"1329\">\u8c03\u63a7\u795e\u7ecf\u5e72\u7ec6\u80de\u7ef4\u6301\u3001\u589e\u6b96\u53ca\u547d\u8fd0\u51b3\u5b9a\u7684\u5173\u952e\u4fe1\u53f7\u901a\u8def\u5305\u62ec\uff1a<\/p>\n<ul data-start=\"1330\" data-end=\"1414\">\n<li data-start=\"1330\" data-end=\"1351\">\n<p data-start=\"1332\" data-end=\"1351\"><strong data-start=\"1332\" data-end=\"1349\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">Wnt\/\u03b2-catenin<\/span><\/span><\/strong><\/p>\n<\/li>\n<li data-start=\"1352\" data-end=\"1365\">\n<p data-start=\"1354\" data-end=\"1365\"><strong data-start=\"1354\" data-end=\"1363\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7f3a\u53e3<\/span><\/span><\/strong><\/p>\n<\/li>\n<li data-start=\"1366\" data-end=\"1393\">\n<p data-start=\"1368\" data-end=\"1393\"><strong data-start=\"1368\" data-end=\"1391\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7d22\u5c3c\u514b\u523a\u732c\uff08\u5618\uff09<\/span><\/span><\/strong><\/p>\n<\/li>\n<li data-start=\"1394\" data-end=\"1414\">\n<p data-start=\"1396\" data-end=\"1414\"><strong data-start=\"1396\" data-end=\"1412\">\u9aa8\u5f62\u6001\u53d1\u751f\u86cb\u767d\uff08BMP\uff09<\/strong><\/p>\n<\/li>\n<\/ul>\n<p data-start=\"1416\" data-end=\"1451\">\u8f6c\u5f55\u56e0\u5b50<strong data-start=\"1420\" data-end=\"1428\">Sox2<\/strong>\u4e0e<strong data-start=\"1429\" data-end=\"1436\">TLX<\/strong>\u5bf9\u81ea\u6211\u66f4\u65b0\u548c\u5206\u5316\u81f3\u5173\u91cd\u8981\uff1a<\/p>\n<ul data-start=\"1452\" data-end=\"1545\">\n<li data-start=\"1452\" data-end=\"1474\">\n<p data-start=\"1454\" data-end=\"1474\">Sox2\u4fc3\u8fdb\u5e72\u7ec6\u80de\u589e\u6b96\u4e0e\u795e\u7ecf\u5143\u6210\u719f\uff1b<\/p>\n<\/li>\n<li data-start=\"1475\" data-end=\"1545\">\n<p data-start=\"1477\" data-end=\"1545\">TLX\u7ef4\u6301\u5176\u672a\u5206\u5316\u72b6\u6001\u3002BMP\u4fe1\u53f7\u4fc3\u8fdb\u5e72\u7ec6\u80de\u9759\u606f\u53ca\u661f\u5f62\u80f6\u8d28\u5206\u5316\uff0c\u800c\u5176\u62ee\u6297\u7269<strong data-start=\"1517\" data-end=\"1527\">Noggin<\/strong>\u53ef\u4fc3\u8fdb\u5e72\u7ec6\u80de\u81ea\u6211\u66f4\u65b0\u4e0e\u795e\u7ecf\u53d1\u751f\u3002<\/p>\n<\/li>\n<\/ul>\n<p data-start=\"1547\" data-end=\"1677\"><strong data-start=\"1547\" 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data-end=\"2392\">\u8fd0\u52a8\u3001\u73af\u5883\u4e30\u5bcc\u5316\u7b49\u751f\u7406\u523a\u6fc0\u53ef\u4fc3\u8fdb\u795e\u7ecf\u53d1\u751f\uff0c\u800c\u5e94\u6fc0\u53ca\u75c5\u7406\u72b6\u6001\uff08\u5982\u766b\u75eb\uff09\u5219\u4f1a\u8c03\u8282\u8fd9\u4e00\u8fc7\u7a0b\u2014\u2014\u766b\u75eb\u53d1\u4f5c\u5728\u6025\u6027\u671f\u53ef\u77ed\u6682\u4fc3\u8fdb\u795e\u7ecf\u53d1\u751f\uff0c\u4f46\u957f\u671f\u5219\u5bfc\u81f4\u795e\u7ecf\u518d\u751f\u53d7\u635f\u3002<\/p>\n<p data-start=\"2394\" data-end=\"2490\">\u795e\u7ecf\u53d1\u751f\uff08Neurogenesis\uff09\u4f7f\u795e\u7ecf\u7cfb\u7edf\u83b7\u5f97\u65b0\u7684\u795e\u7ecf\u5143\u6765\u6e90\uff0c\u589e\u5f3a\u795e\u7ecf\u53ef\u5851\u6027\u3002\u795e\u7ecf\u53d1\u751f\u5fae\u73af\u5883\u7531\u4fe1\u53f7\u5206\u5b50\u3001\u7ec6\u80de\u5916\u57fa\u8d28\u53ca\u7ec6\u80de\u95f4\u76f8\u4e92\u4f5c\u7528\u7ec4\u6210\uff0c\u51b3\u5b9a\u7740\u5e72\u7ec6\u80de\u7684\u81ea\u6211\u66f4\u65b0\u3001\u5206\u5316\u4e0e\u795e\u7ecf\u53d1\u751f\u80fd\u529b\u3002<\/p>\n<hr data-start=\"2492\" data-end=\"2495\" \/>\n<h2 data-start=\"2497\" data-end=\"2523\"><span class=\"ez-toc-section\" id=\"%E5%9B%9B%E3%80%81%E7%A5%9E%E7%BB%8F%E5%B9%B2%E7%BB%86%E8%83%9E%E5%9C%A8%E7%A5%9E%E7%BB%8F%E7%B3%BB%E7%BB%9F%E7%96%BE%E7%97%85%E4%B8%8E%E6%8D%9F%E4%BC%A4%E4%B8%AD%E7%9A%84%E4%BD%9C%E7%94%A8\"><\/span>\u56db\u3001\u795e\u7ecf\u5e72\u7ec6\u80de\u5728\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u4e0e\u635f\u4f24\u4e2d\u7684\u4f5c\u7528<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p data-start=\"2525\" data-end=\"2596\">\u5728\u6210\u4eba\u8111\u4e2d\uff0c\u795e\u7ecf\u5e72\u7ec6\u80de\u4e3b\u8981\u5b58\u5728\u4e8e\u4fa7\u8111\u5ba4\u4e0b\u533a\uff08SVZ\uff09\u4e0e\u6d77\u9a6c\u9f7f\u72b6\u56de\u4e0b\u9897\u7c92\u533a\uff08SGZ\uff09\uff0c\u53ef\u81ea\u6211\u66f4\u65b0\u5e76\u5206\u5316\u4e3a\u795e\u7ecf\u5143\u3001\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u4e0e\u5c11\u7a81\u80f6\u8d28\u7ec6\u80de\u3002<\/p>\n<p data-start=\"2598\" data-end=\"2670\">\u5728\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u4e2d\uff0c\u5982<strong data-start=\"2609\" data-end=\"2623\">\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\uff08AD\uff09<\/strong>,<strong data-start=\"2624\" data-end=\"2650\">\u5e15\u91d1\u68ee\u75c5\uff08PD\uff09\u4e0e\u591a\u53d1\u6027\u786c\u5316\uff08MS\uff09<\/strong>\uff0c\u795e\u7ecf\u5e72\u7ec6\u80de\u7684\u589e\u6b96\u4e0e\u795e\u7ecf\u53d1\u751f\u5747\u53d7\u635f\uff1a<\/p>\n<ul data-start=\"2671\" data-end=\"2719\">\n<li data-start=\"2671\" data-end=\"2691\">\n<p data-start=\"2673\" data-end=\"2691\">AD\u60a3\u8005\u7684\u524d\u4f53\u7ec6\u80de\u589e\u6b96\u80fd\u529b\u4e0b\u964d\uff1b<\/p>\n<\/li>\n<li data-start=\"2692\" data-end=\"2719\">\n<p data-start=\"2694\" data-end=\"2719\">PD\u4e2d\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u7f3a\u5931\u5bfc\u81f4\u524d\u4f53\u7ec6\u80de\u6570\u91cf\u51cf\u5c11\u3002<\/p>\n<\/li>\n<\/ul>\n<p data-start=\"2721\" data-end=\"2821\">\u5728\u4e2d\u98ce\uff08\u5352\u4e2d\uff09<strong data-start=\"2730\" data-end=\"2735\">up to<\/strong>\u521b\u4f24\u6027\u8111\u635f\u4f24\uff08TBI\uff09\u7b49\u4e2d\u67a2\u795e\u7ecf\u635f\u4f24\u540e\uff0c\u5185\u6e90\u6027\u795e\u7ecf\u5e72\u7ec6\u80de\u88ab\u6fc0\u6d3b\u5e76\u8fc1\u79fb\u81f3\u635f\u4f24\u533a\uff0c\u4f46\u65b0\u751f\u795e\u7ecf\u5143\u7684\u5b58\u6d3b\u7387\u6781\u4f4e\uff0c\u4f8b\u5982\u5728\u7f3a\u8840\u6027\u635f\u4f24\u5927\u9f20\u6a21\u578b\u4e2d\uff0c\u4ec5\u7ea60.2%\u7684\u53d7\u635f\u795e\u7ecf\u5143\u88ab\u66ff\u4ee3\u3002<\/p>\n<p data-start=\"2823\" data-end=\"2975\">\u635f\u4f24\u533a\u5f62\u6210\u7684<strong data-start=\"2829\" data-end=\"2837\">\u80f6\u8d28\u7622\u75d5<\/strong>\u4f1a\u9650\u5236\u795e\u7ecf\u5e72\u7ec6\u80de\u7684\u5206\u5316\u4e0e\u6574\u5408\uff0c\u4f7f\u5176\u66f4\u6613\u5206\u5316\u4e3a\u80f6\u8d28\u7ec6\u80de\u800c\u975e\u795e\u7ecf\u5143\u3002\u795e\u7ecf\u5e72\u7ec6\u80de\u529f\u80fd\u969c\u788d\uff08\u5982\u81ea\u6211\u66f4\u65b0\u80fd\u529b\u4e0b\u964d\u3001\u5206\u5316\u53d7\u963b\uff09\u4f1a\u52a0\u91cd\u75c5\u7406\u72b6\u6001\uff0c\u5e76\u53d7\u8001\u5316\u3001\u708e\u75c7\u53ca\u8868\u89c2\u9057\u4f20\u5f02\u5e38\u5f71\u54cd\u3002\u5728\u766b\u75eb\u7b49\u75be\u75c5\u4e2d\u51fa\u73b0\u7684<strong data-start=\"2935\" data-end=\"2945\">\u5f02\u5e38\u795e\u7ecf\u53d1\u751f<\/strong>\u53ef\u80fd\u5bfc\u81f4\u65b0\u751f\u795e\u7ecf\u5143\u8fc1\u79fb\u4e0e\u6574\u5408\u5931\u8d25\uff0c\u4ece\u800c\u589e\u52a0\u766b\u75eb\u590d\u53d1\u98ce\u9669\u3002<\/p>\n<p data-start=\"2977\" data-end=\"3025\">\u795e\u7ecf\u5e72\u7ec6\u80de\u8fd8\u80fd\u4e0e\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u514d\u75ab\u53cd\u5e94\u4e92\u4f5c\uff0c\u8c03\u8282\u708e\u75c7\u5e76\u4fc3\u8fdb\u4fee\u590d\u3002\u7814\u7a76\u8868\u660e\uff0c\u79fb\u690d\u7684\u795e\u7ecf\u5e72\u7ec6\u80de\u53ef\uff1a<\/p>\n<ul data-start=\"3026\" data-end=\"3072\">\n<li data-start=\"3026\" data-end=\"3037\">\n<p data-start=\"3028\" data-end=\"3037\">\u6291\u5236\u708e\u75c7\u53cd\u5e94\uff1b<\/p>\n<\/li>\n<li data-start=\"3038\" data-end=\"3051\">\n<p data-start=\"3040\" data-end=\"3051\">\u51cf\u5c11\u514d\u75ab\u7ec6\u80de\u6d78\u6da6\uff1b<\/p>\n<\/li>\n<li data-start=\"3052\" data-end=\"3072\">\n<p data-start=\"3054\" data-end=\"3072\">\u5206\u6ccc\u4fc3\u8840\u7ba1\u751f\u6210\u53ca\u4fee\u590d\u7684\u8425\u517b\u56e0\u5b50\u3002<\/p>\n<\/li>\n<\/ul>\n<p data-start=\"3074\" data-end=\"3174\">\u5176\u4fee\u590d\u673a\u5236\u6d89\u53ca<strong data-start=\"3081\" data-end=\"3104\">Notch\u3001Wnt\/\u03b2-Catenin<\/strong>up to<strong data-start=\"3105\" data-end=\"3170\">\u8111\u6e90\u6027\u795e\u7ecf\u8425\u517b\u56e0\u5b50\uff08BDNF\uff09\u7b49\u4fe1\u53f7\u901a\u8def\u3002\u7136\u800c\uff0c\u5e72\u7ec6\u80de\u7597\u6cd5\u7684\u7597\u6548\u4ecd\u53d7\u9650\u4e8e\u7ec6\u80de\u5b58\u6d3b\u7387\u4f4e\u3001\u5206\u5316\u53d7\u9650\u53ca\u6291\u5236\u6027\u5fae\u73af\u5883<\/strong>\u7b49\u56e0\u7d20\u3002<\/p>\n<hr data-start=\"3176\" data-end=\"3179\" \/>\n<h2 data-start=\"3181\" data-end=\"3206\"><span class=\"ez-toc-section\" id=\"%E4%BA%94%E3%80%81%E7%A5%9E%E7%BB%8F%E5%B9%B2%E7%BB%86%E8%83%9E%E7%9A%84%E6%B2%BB%E7%96%97%E5%BA%94%E7%94%A8%E3%80%81%E6%8C%91%E6%88%98%E4%B8%8E%E6%9C%AA%E6%9D%A5%E6%96%B9%E5%90%91\"><\/span>\u4e94\u3001\u795e\u7ecf\u5e72\u7ec6\u80de\u7684\u6cbb\u7597\u5e94\u7528\u3001\u6311\u6218\u4e0e\u672a\u6765\u65b9\u5411<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p data-start=\"3208\" data-end=\"3281\">\u795e\u7ecf\u5e72\u7ec6\u80de\u4f5c\u4e3a\u591a\u80fd\u524d\u4f53\u7ec6\u80de\uff0c\u5177\u6709\u81ea\u6211\u66f4\u65b0\u53ca\u5206\u5316\u4e3a\u795e\u7ecf\u5143\u3001\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u4e0e\u5c11\u7a81\u80f6\u8d28\u7ec6\u80de\u7684\u80fd\u529b\uff0c\u5e76\u5728\u4e00\u751f\u4e2d\u6301\u7eed\u5b58\u5728\u4e8e\u5982SVZ\u4e0e\u9f7f\u72b6\u56de\u7b49\u795e\u7ecf\u53d1\u751f\u533a\u4e2d\u3002<\/p>\n<p data-start=\"3283\" data-end=\"3294\">\u8fd9\u4e9b\u7ec6\u80de\u53ef\u6765\u6e90\u4e8e\uff1a<\/p>\n<ul data-start=\"3295\" data-end=\"3349\">\n<li data-start=\"3295\" data-end=\"3303\">\n<p data-start=\"3297\" data-end=\"3303\">\u80ce\u513f\u7ec4\u7ec7<\/p>\n<\/li>\n<li data-start=\"3304\" data-end=\"3319\">\n<p data-start=\"3306\" data-end=\"3319\">\u80da\u80ce\u5e72\u7ec6\u80de\uff08ESCs\uff09<\/p>\n<\/li>\n<li data-start=\"3320\" data-end=\"3338\">\n<p data-start=\"3322\" data-end=\"3338\">Induced Pluripotent Stem Cells (iPSCs)<\/p>\n<\/li>\n<li data-start=\"3339\" data-end=\"3349\">\n<p data-start=\"3341\" data-end=\"3349\">\u6210\u4eba\u6765\u6e90\u7ec6\u80de<\/p>\n<\/li>\n<\/ul>\n<p data-start=\"3351\" data-end=\"3372\">\u4e0d\u540c\u6765\u6e90\u5728\u79fb\u690d\u6cbb\u7597\u4e2d\u7684\u4f18\u52bf\u4e0e\u6311\u6218\u5404\u5f02\u3002<\/p>\n<p data-start=\"3374\" data-end=\"3502\">\u795e\u7ecf\u5e72\u7ec6\u80de\u9002\u5408\u8fdb\u884c<strong data-start=\"3383\" data-end=\"3393\">\u57fa\u56e0\u5de5\u7a0b\u6539\u9020<\/strong>\uff0c\u5e38\u7528\u6280\u672f\u5305\u62ec\u75c5\u6bd2\u8f7d\u4f53\u8f6c\u67d3\u3001\u8102\u8d28\u4f53\u8f6c\u67d3\u3001\u7535\u7a7f\u5b54\u53ca\u78f7\u9178\u9499\u5171\u6c89\u6dc0\u7b49\uff0c\u53ef\u7528\u4e8e\u4f53\u5916\u4fee\u9970\u4ee5\u8868\u8fbe\u6cbb\u7597\u6027\u5206\u5b50\u3002<br data-start=\"3441\" data-end=\"3444\" \/><strong data-start=\"3444\" data-end=\"3459\">CRISPR\/Cas9<\/strong>\u57fa\u56e0\u7f16\u8f91\u6280\u672f\u5df2\u5e7f\u6cdb\u5e94\u7528\u4e8e\u795e\u7ecf\u5e72\u7ec6\u80de\u4e0eiPSCs\uff0c\u53ef\u5b9e\u73b0\u7cbe\u786e\u57fa\u56e0\u6821\u6b63\u6216\u75be\u75c5\u7a81\u53d8\u4fee\u590d\u3002<\/p>\n<p data-start=\"3504\" data-end=\"3519\">\u5e72\u7ec6\u80de\u6cbb\u7597\u7684\u4e3b\u8981\u6311\u6218\u5305\u62ec\uff1a<\/p>\n<ul data-start=\"3520\" data-end=\"3562\">\n<li data-start=\"3520\" data-end=\"3534\">\n<p data-start=\"3522\" data-end=\"3534\"><strong data-start=\"3522\" data-end=\"3532\">immune rejection<\/strong><\/p>\n<\/li>\n<li data-start=\"3535\" data-end=\"3549\">\n<p data-start=\"3537\" data-end=\"3549\"><strong data-start=\"3537\" data-end=\"3547\">\u80bf\u7624\u5f62\u6210\u98ce\u9669<\/strong><\/p>\n<\/li>\n<li data-start=\"3550\" data-end=\"3562\">\n<p data-start=\"3552\" data-end=\"3562\"><strong data-start=\"3552\" data-end=\"3560\">\u4f26\u7406\u4e89\u8bae<\/strong><\/p>\n<\/li>\n<\/ul>\n<p data-start=\"3564\" data-end=\"3685\">\u79fb\u690d\u53ef\u80fd\u5f15\u53d1\u5bbf\u4e3b\u514d\u75ab\u53cd\u5e94\u5bfc\u81f4\u79fb\u690d\u7269\u7834\u574f\uff0c\u89e3\u51b3\u7b56\u7565\u5305\u62ec\u4f7f\u7528\u60a3\u8005\u7279\u5f02\u6027\u5e72\u7ec6\u80de\u53ca\u514d\u75ab\u6291\u5236\u7597\u6cd5\u3002\u591a\u80fd\u5e72\u7ec6\u80de\u6765\u6e90\u7684\u795e\u7ecf\u5e72\u7ec6\u80de\u53ef\u80fd\u5177\u6709\u80bf\u7624\u5f62\u6210\u98ce\u9669\uff0c\u56e0\u6b64\u9700\u4e25\u683c\u5b89\u5168\u8bc4\u4f30\u3002\u80da\u80ce\u6216\u80ce\u513f\u6765\u6e90\u7ec6\u80de\u5f15\u53d1\u4f26\u7406\u95ee\u9898\uff0c\u800ciPSC\u6765\u6e90\u7ec6\u80de\u53ef\u5728\u4e00\u5b9a\u7a0b\u5ea6\u4e0a\u907f\u514d\u3002<\/p>\n<p data-start=\"3687\" 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