{"id":20413,"date":"2025-11-12T15:31:56","date_gmt":"2025-11-12T07:31:56","guid":{"rendered":"https:\/\/www.hjtdsm.cn\/?p=20413"},"modified":"2025-11-12T15:31:56","modified_gmt":"2025-11-12T07:31:56","slug":"%e7%a5%9e%e7%bb%8f%e5%b9%b2%e7%bb%86%e8%83%9e%e5%88%86%e5%8c%96","status":"publish","type":"post","link":"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/nsc\/20413.html","title":{"rendered":"\u795e\u7ecf\u5e72\u7ec6\u80de\u5206\u5316\u7ec8\u6781\u6307\u5357\uff1a\u4ece\u673a\u5236\u3001\u8fc7\u7a0b\u5230\u7cbe\u51c6\u8c03\u63a7"},"content":{"rendered":"<blockquote>\n<p class=\"ds-markdown-paragraph\">\u5927\u8111\u5185\u7684\u6bcf\u4e00\u6b21\u4fee\u590d\u4e0e\u91cd\u5851\uff0c\u90fd\u59cb\u4e8e\u4e00\u573a\u9759\u9ed8\u800c\u7cbe\u5bc6\u7684\u7ec6\u80de\u5206\u5316\u4e4b\u65c5\u3002<\/p>\n<\/blockquote>\n<p class=\"ds-markdown-paragraph\">\u5728\u795e\u7ecf\u79d1\u5b66\u548c\u518d\u751f\u533b\u5b66\u9886\u57df\uff0c<strong>\u795e\u7ecf\u5e72\u7ec6\u80de\u5206\u5316<\/strong>\u662f\u4e00\u4e2a\u6838\u5fc3\u8fdb\u7a0b\u3002\u5b83\u4e0d\u4ec5\u662f\u5927\u8111\u53d1\u80b2\u7684\u57fa\u7840\uff0c<a href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/nsc\/20408.html\/\" target=\"_blank\" rel=\"noopener\">\u66f4\u662f\u6cbb\u7597\u795e\u7ecf\u7cfb\u7edf\u635f\u4f24\u4e0e\u75be\u75c5\u7684\u5e0c\u671b\u6240\u5728<\/a>\u3002\u7406\u89e3\u795e\u7ecf\u5e72\u7ec6\u80de\u5982\u4f55\u8f6c\u53d8\u4e3a\u6210\u719f\u7684\u795e\u7ecf\u7ec6\u80de\uff0c\u610f\u5473\u7740\u638c\u63e1\u4e86\u4fee\u590d\u5927\u8111\u7684\u6f5c\u5728\u94a5\u5319\u3002\u672c\u6587\u5c06\u5168\u65b9\u4f4d\u89e3\u6790\u795e\u7ecf\u5e72\u7ec6\u80de\u5206\u5316\u7684\u673a\u5236\u3001\u8fc7\u7a0b\u4e0e\u5e94\u7528\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-20415 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/istockphoto-1684997822-612x612-1.jpg\" alt=\"\u795e\u7ecf\u5e72\u7ec6\u80de\u5206\u5316\u7ec8\u6781\u6307\u5357\uff1a\u4ece\u673a\u5236\u3001\u8fc7\u7a0b\u5230\u7cbe\u51c6\u8c03\u63a7\" width=\"612\" height=\"344\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/istockphoto-1684997822-612x612-1.jpg 612w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/istockphoto-1684997822-612x612-1-300x169.jpg 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/istockphoto-1684997822-612x612-1-18x10.jpg 18w\" sizes=\"(max-width: 612px) 100vw, 612px\" \/><\/p>\n<hr \/>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_79_2 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewbox=\"0 0 24 24\" version=\"1.2\" baseprofile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/nsc\/20413.html\/#01_%E5%88%86%E5%8C%96%E5%9F%BA%E7%9F%B3%EF%BC%9A%E7%A5%9E%E7%BB%8F%E5%B9%B2%E7%BB%86%E8%83%9E%E7%9A%84%E4%B8%A4%E5%A4%A7%E6%A0%B8%E5%BF%83%E6%BD%9C%E8%83%BD\" >01 \u5206\u5316\u57fa\u77f3\uff1a\u795e\u7ecf\u5e72\u7ec6\u80de\u7684\u4e24\u5927\u6838\u5fc3\u6f5c\u80fd<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/nsc\/20413.html\/#02_%E5%91%BD%E8%BF%90%E6%8A%89%E6%8B%A9%EF%BC%9A%E7%A5%9E%E7%BB%8F%E5%B9%B2%E7%BB%86%E8%83%9E%E5%88%86%E5%8C%96%E6%88%90%E4%BB%80%E4%B9%88%EF%BC%9F\" >02 \u547d\u8fd0\u6289\u62e9\uff1a\u795e\u7ecf\u5e72\u7ec6\u80de\u5206\u5316\u6210\u4ec0\u4e48\uff1f<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/nsc\/20413.html\/#03_%E7%B2%BE%E5%AF%86%E8%B0%83%E6%8E%A7%EF%BC%9A%E7%A5%9E%E7%BB%8F%E5%B9%B2%E7%BB%86%E8%83%9E%E5%A6%82%E4%BD%95%E5%88%86%E5%8C%96%EF%BC%9F\" >03 \u7cbe\u5bc6\u8c03\u63a7\uff1a\u795e\u7ecf\u5e72\u7ec6\u80de\u5982\u4f55\u5206\u5316\uff1f<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/nsc\/20413.html\/#04_%E4%BD%93%E5%A4%96%E5%AE%9A%E5%90%91%E8%AF%B1%E5%AF%BC%EF%BC%9A%E4%BA%BA%E7%B1%BB%E5%A4%9A%E8%83%BD%E5%B9%B2%E7%BB%86%E8%83%9E%E7%9A%84%E7%A5%9E%E7%BB%8F%E5%88%86%E5%8C%96\" >04 \u4f53\u5916\u5b9a\u5411\u8bf1\u5bfc\uff1a\u4eba\u7c7b\u591a\u80fd\u5e72\u7ec6\u80de\u7684\u795e\u7ecf\u5206\u5316<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/nsc\/20413.html\/#05_%E8%AF%86%E5%88%AB%E4%B8%8E%E9%89%B4%E5%AE%9A%EF%BC%9A%E7%A5%9E%E7%BB%8F%E5%B9%B2%E7%BB%86%E8%83%9E%E5%88%86%E5%8C%96%E6%A0%87%E5%BF%97%E7%89%A9\" >05 \u8bc6\u522b\u4e0e\u9274\u5b9a\uff1a\u795e\u7ecf\u5e72\u7ec6\u80de\u5206\u5316\u6807\u5fd7\u7269<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/nsc\/20413.html\/#06_%E4%BD%93%E5%A4%96%E5%9F%B9%E5%85%BB%E7%9A%84%E5%9F%BA%E7%9F%B3%EF%BC%9A%E7%A5%9E%E7%BB%8F%E5%B9%B2%E7%BB%86%E8%83%9E%E5%88%86%E5%8C%96%E5%9F%B9%E5%85%BB%E5%9F%BA\" >06 \u4f53\u5916\u57f9\u517b\u7684\u57fa\u77f3\uff1a\u795e\u7ecf\u5e72\u7ec6\u80de\u5206\u5316\u57f9\u517b\u57fa<\/a><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"01_%E5%88%86%E5%8C%96%E5%9F%BA%E7%9F%B3%EF%BC%9A%E7%A5%9E%E7%BB%8F%E5%B9%B2%E7%BB%86%E8%83%9E%E7%9A%84%E4%B8%A4%E5%A4%A7%E6%A0%B8%E5%BF%83%E6%BD%9C%E8%83%BD\"><\/span>01 \u5206\u5316\u57fa\u77f3\uff1a\u795e\u7ecf\u5e72\u7ec6\u80de\u7684\u4e24\u5927\u6838\u5fc3\u6f5c\u80fd<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p class=\"ds-markdown-paragraph\"><a href=\"https:\/\/www.sciencedirect.com\/topics\/neuroscience\/neural-stem-cell\" target=\"_blank\" rel=\"noopener nofollow\">neural stem cell<\/a>\u4e4b\u6240\u4ee5\u6210\u4e3a\u518d\u751f\u533b\u5b66\u7684\u660e\u661f\uff0c\u6e90\u4e8e\u5176\u4e24\u5927\u6838\u5fc3\u7279\u6027\uff1a<strong>\u65e0\u9650\u7684\u81ea\u6211\u66f4\u65b0\u80fd\u529b<\/strong>\u4e0e\u00a0<strong>\u591a\u5411\u5206\u5316\u6f5c\u80fd<\/strong>The<\/p>\n<p class=\"ds-markdown-paragraph\">\u8fd9\u610f\u5473\u7740\uff0c\u5b83\u4eec\u65e2\u80fd\u901a\u8fc7\u5206\u88c2\u4e0d\u65ad\u590d\u5236\u81ea\u8eab\uff0c\u7ef4\u6301\u5e72\u7ec6\u80de\u6c60\u7684\u7a33\u5b9a\uff1b\u53c8\u80fd\u6839\u636e\u673a\u4f53\u4fe1\u53f7\uff0c\u5206\u5316\u4e3a\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u7684\u6240\u6709\u4e09\u79cd\u4e3b\u8981\u529f\u80fd\u7ec6\u80de\uff1a<br \/>\n<strong>\u795e\u7ecf\u5143<\/strong>,<strong>\u661f\u5f62\u80f6\u8d28\u7ec6\u80de<\/strong>respond in singing<strong>\u5c11\u7a81\u80f6\u8d28\u7ec6\u80de<\/strong>The<\/p>\n<p class=\"ds-markdown-paragraph\">\u8fd9\u79cd\u4ece\u201c\u4e07\u80fd\u201d\u5230\u201c\u4e13\u7cbe\u201d\u7684\u8f6c\u53d8\uff0c\u662f\u4e00\u4e2a\u53d7\u5230\u7cbe\u5bc6\u8c03\u63a7\u7684\u590d\u6742\u8fc7\u7a0b\uff0c\u662f\u795e\u7ecf\u53d1\u751f\u3001\u80f6\u8d28\u53d1\u751f\u4ee5\u53ca\u6700\u7ec8\u5b9e\u73b0\u795e\u7ecf\u56de\u8def\u529f\u80fd\u6574\u5408\u7684\u8d77\u70b9\u3002<\/p>\n<h2><span class=\"ez-toc-section\" id=\"02_%E5%91%BD%E8%BF%90%E6%8A%89%E6%8B%A9%EF%BC%9A%E7%A5%9E%E7%BB%8F%E5%B9%B2%E7%BB%86%E8%83%9E%E5%88%86%E5%8C%96%E6%88%90%E4%BB%80%E4%B9%88%EF%BC%9F\"><\/span>02 \u547d\u8fd0\u6289\u62e9\uff1a\u795e\u7ecf\u5e72\u7ec6\u80de\u5206\u5316\u6210\u4ec0\u4e48\uff1f<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p class=\"ds-markdown-paragraph\">\u5f53\u795e\u7ecf\u5e72\u7ec6\u80de\u542f\u52a8\u5206\u5316\u7a0b\u5e8f\uff0c\u5176\u547d\u8fd0\u8d70\u5411\u5e76\u975e\u968f\u673a\uff0c\u800c\u662f\u7531\u5185\u5916\u4fe1\u53f7\u5171\u540c\u51b3\u5b9a\u7684\u3002\u5176\u4e3b\u8981\u5206\u5316\u65b9\u5411\u5305\u62ec\uff1a<\/p>\n<ul>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>\u795e\u7ecf\u5143<\/strong>\uff1a\u8d1f\u8d23\u63a5\u6536\u3001\u5904\u7406\u548c\u4f20\u9012\u795e\u7ecf\u7535\u4fe1\u53f7\uff0c\u662f\u6784\u6210\u795e\u7ecf\u7f51\u7edc\u529f\u80fd\u7684\u57fa\u7840\u5355\u5143\u3002<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>\u661f\u5f62\u80f6\u8d28\u7ec6\u80de<\/strong>\uff1a\u4e3a\u795e\u7ecf\u5143\u63d0\u4f9b\u8425\u517b\u652f\u6301\u3001\u7ef4\u6301\u7ec6\u80de\u5916\u79bb\u5b50\u5e73\u8861\uff0c\u5e76\u53c2\u4e0e\u8840\u8111\u5c4f\u969c\u7684\u5f62\u6210\u4e0e\u7a81\u89e6\u529f\u80fd\u7684\u8c03\u8282\u3002<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>\u5c11\u7a81\u80f6\u8d28\u7ec6\u80de<\/strong>\uff1a\u5728\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u4e2d\u5305\u88f9\u8f74\u7a81\uff0c\u5f62\u6210\u9ad3\u9798\uff0c\u50cf\u7535\u7ebf\u7edd\u7f18\u5c42\u4e00\u6837\u786e\u4fdd\u795e\u7ecf\u4fe1\u53f7\u7684\u9ad8\u901f\u4f20\u5bfc\u3002<\/p>\n<\/li>\n<\/ul>\n<p class=\"ds-markdown-paragraph\">\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0cNSCs\u53ca\u5176\u5b50\u4ee3\u7ec6\u80de\u5177\u6709\u9ad8\u5ea6<strong>\u5f02\u8d28\u6027<\/strong>\uff0c\u4e0d\u540c\u4e9a\u7fa4\u56e0\u5176\u533a\u57df\u8eab\u4efd\u548c\u5206\u5b50\u7279\u5f81\uff0c\u5176\u5206\u5316\u503e\u5411\u4e5f\u5404\u4e0d\u76f8\u540c\u3002<\/p>\n<h2><span class=\"ez-toc-section\" id=\"03_%E7%B2%BE%E5%AF%86%E8%B0%83%E6%8E%A7%EF%BC%9A%E7%A5%9E%E7%BB%8F%E5%B9%B2%E7%BB%86%E8%83%9E%E5%A6%82%E4%BD%95%E5%88%86%E5%8C%96%EF%BC%9F\"><\/span>03 \u7cbe\u5bc6\u8c03\u63a7\uff1a\u795e\u7ecf\u5e72\u7ec6\u80de\u5982\u4f55\u5206\u5316\uff1f<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p class=\"ds-markdown-paragraph\">\u5206\u5316\u8fc7\u7a0b\u5982\u540c\u4e00\u573a\u7cbe\u5fc3\u7f16\u6392\u7684\u4ea4\u54cd\u4e50\uff0c\u53d7\u5230\u591a\u91cd\u56e0\u7d20\u7684\u7cbe\u5bc6\u8c03\u63a7\u3002<\/p>\n<ul>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>\u5173\u952e\u4fe1\u53f7\u901a\u8def<\/strong>\uff1a\u8bf8\u5982\u00a0<strong>Wnt\/\u03b2-\u8fde\u73af\u86cb\u767d<\/strong>,<strong>Notch<\/strong>,<strong>Sonic Hedgehog<\/strong>\u00a0respond in singing<strong>\u9aa8\u5f62\u6001\u53d1\u751f\u86cb\u767d<\/strong>\u00a0\u7b49\u6838\u5fc3\u4fe1\u53f7\u901a\u8def\uff0c\u6784\u6210\u4e86\u8c03\u63a7NSCs\u7ef4\u6301\u3001\u589e\u6b96\u4e0e\u547d\u8fd0\u51b3\u5b9a\u7684\u5206\u5b50\u5f00\u5173\u7f51\u7edc\u3002<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>\u8f6c\u5f55\u56e0\u5b50<\/strong>::<strong>Sox2<\/strong>,<strong>TLX<\/strong>\u7b49\u8f6c\u5f55\u56e0\u5b50\u662f\u6267\u884c\u5206\u5316\u6307\u4ee4\u7684\u5173\u952e\u86cb\u767d\u3002Sox2\u4e3aNSCs\u589e\u6b96\u548c\u795e\u7ecf\u5143\u6210\u719f\u6240\u5fc5\u9700\uff0c\u800cTLX\u5219\u8d1f\u8d23\u7ef4\u6301NSCs\u7684\u672a\u5206\u5316\u72b6\u6001\u3002<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>\u8868\u89c2\u9057\u4f20\u4e0e\u4ee3\u8c22\u8c03\u63a7<\/strong>\uff1a\u67d3\u8272\u8d28\u91cd\u5851\u3001\u975e\u7f16\u7801RNA\u7b49\u8868\u89c2\u9057\u4f20\u673a\u5236\u51b3\u5b9a\u4e86\u57fa\u56e0\u7684\u53ef\u53ca\u6027\uff0c\u5f71\u54cd\u7740NSCs\u7684\u5206\u5316\u65b9\u5411\u3002\u540c\u65f6\uff0cNSCs\u4f18\u5148\u5229\u7528\u7cd6\u9175\u89e3\u4ee3\u8c22\uff0c\u5176\u9759\u606f\u4e0e\u6fc0\u6d3b\u72b6\u6001\u7684\u8f6c\u6362\u4e5f\u6df1\u53d7\u8425\u517b\u53ef\u7528\u6027\u4e0e\u4ee3\u8c22\u4fe1\u53f7\u7684\u5f71\u97ff\u3002<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>\u5fae\u73af\u5883\uff08\u9f9b\u4f4d\uff09<\/strong>\uff1aNSCs\u5b58\u5728\u4e8e<strong>\u8111\u5ba4\u4e0b\u533a<\/strong>respond in singing<strong>\u6d77\u9a6c\u9897\u7c92\u4e0b\u533a<\/strong>\u7b49\u7279\u6b8a\u5fae\u73af\u5883\u4e2d\u3002\u8fd9\u4e9b\u9f9b\u4f4d\u901a\u8fc7\u7ec6\u80de\u5916\u57fa\u8d28\uff08\u5982\u5c42\u7c98\u8fde\u86cb\u767d\u3001\u751f\u8171\u86cb\u767d\uff09\u3001\u8840\u7ba1\u4fe1\u53f7\u4ee5\u53ca\u7ec6\u80de\u95f4\u76f8\u4e92\u4f5c\u7528\uff0c\u4e3a\u5206\u5316\u63d0\u4f9b\u4e86\u5fc5\u8981\u7684\u7ed3\u6784\u652f\u6301\u548c\u5206\u5b50\u4fe1\u53f7\u3002<\/p>\n<\/li>\n<\/ul>\n<h2><span class=\"ez-toc-section\" id=\"04_%E4%BD%93%E5%A4%96%E5%AE%9A%E5%90%91%E8%AF%B1%E5%AF%BC%EF%BC%9A%E4%BA%BA%E7%B1%BB%E5%A4%9A%E8%83%BD%E5%B9%B2%E7%BB%86%E8%83%9E%E7%9A%84%E7%A5%9E%E7%BB%8F%E5%88%86%E5%8C%96\"><\/span>04 \u4f53\u5916\u5b9a\u5411\u8bf1\u5bfc\uff1a\u4eba\u7c7b\u591a\u80fd\u5e72\u7ec6\u80de\u7684\u795e\u7ecf\u5206\u5316<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p class=\"ds-markdown-paragraph\">\u5728\u5b9e\u9a8c\u5ba4\u4e2d\uff0c\u5b9a\u5411\u8bf1\u5bfc\u4eba\u7c7b\u591a\u80fd\u5e72\u7ec6\u80de\uff08\u5305\u62ec<strong>embryonic stem cell<\/strong>respond in singing<strong>induced pluripotent stem cell<\/strong>\uff09\u5206\u5316\u4e3a\u7279\u5b9a\u795e\u7ecf\u7ec6\u80de\uff0c\u662f\u8fdb\u884c\u7814\u7a76\u4e0e\u7ec6\u80de\u6cbb\u7597\u7684\u57fa\u7840\u3002<\/p>\n<p class=\"ds-markdown-paragraph\">\u5176\u57fa\u672c\u8303\u5f0f\u662f\u6a21\u62df\u4f53\u5185\u53d1\u80b2\u8fc7\u7a0b\uff0c\u901a\u8fc7\u7cbe\u786e\u64cd\u63a7\u4fe1\u53f7\u901a\u8def\uff0c\u5f15\u5bfc\u7ec6\u80de\u7ecf\u5386\u4e00\u7cfb\u5217\u5173\u952e\u9636\u6bb5\uff1a<br \/>\n<strong>\u591a\u80fd\u5e72\u7ec6\u80de \u2192 \u795e\u7ecf\u4e0a\u76ae\u7ec6\u80de \u2192 \u653e\u5c04\u72b6\u80f6\u8d28\u7ec6\u80de\uff08\u771f\u6b63\u7684NSCs\uff09\u2192 \u7279\u5b9a\u7684\u795e\u7ecf\u5143\u6216\u80f6\u8d28\u7ec6\u80de\u524d\u4f53 \u2192 \u6210\u719f\u7684\u795e\u7ecf\u7ec6\u80de<\/strong>The<\/p>\n<p class=\"ds-markdown-paragraph\">\u4f8b\u5982\uff0c\u901a\u8fc7\u6291\u5236BMP\u548cTGF-\u03b2\u4fe1\u53f7\u53ef\u8bf1\u5bfc\u795e\u7ecf\u80da\u5c42\u5f62\u6210\uff1b\u968f\u540e\u4f7f\u7528\u97f3\u732c\u56e0\u5b50\u7b49\u6a21\u5f0f\u5316\u56e0\u5b50\uff0c\u53ef\u8fdb\u4e00\u6b65\u6307\u5bfc\u7ec6\u80de\u5206\u5316\u4e3a\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u3001\u8fd0\u52a8\u795e\u7ecf\u5143\u7b49\u7279\u5b9a\u4e9a\u578b\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-20416 aligncenter\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/istockphoto-2066255011-612x612-1.jpg\" alt=\"\" width=\"612\" height=\"344\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/istockphoto-2066255011-612x612-1.jpg 612w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/istockphoto-2066255011-612x612-1-300x169.jpg 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/istockphoto-2066255011-612x612-1-18x10.jpg 18w\" sizes=\"(max-width: 612px) 100vw, 612px\" \/><\/p>\n<h2><span class=\"ez-toc-section\" id=\"05_%E8%AF%86%E5%88%AB%E4%B8%8E%E9%89%B4%E5%AE%9A%EF%BC%9A%E7%A5%9E%E7%BB%8F%E5%B9%B2%E7%BB%86%E8%83%9E%E5%88%86%E5%8C%96%E6%A0%87%E5%BF%97%E7%89%A9\"><\/span>05 \u8bc6\u522b\u4e0e\u9274\u5b9a\uff1a\u795e\u7ecf\u5e72\u7ec6\u80de\u5206\u5316\u6807\u5fd7\u7269<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p class=\"ds-markdown-paragraph\">\u5728\u5206\u5316\u8fc7\u7a0b\u4e2d\uff0c\u7ec6\u80de\u4f1a\u8868\u8fbe\u7279\u5b9a\u7684\u5206\u5b50\u6807\u8bb0\u7269\uff0c\u8fd9\u4e9b<strong>\u6807\u5fd7\u7269<\/strong>\u5982\u540c\u7ec6\u80de\u7684\u8eab\u4efdID\uff0c\u5e2e\u52a9\u6211\u4eec\u8bc6\u522b\u548c\u8ffd\u8e2a\u5176\u5206\u5316\u9636\u6bb5\u4e0e\u7c7b\u578b\u3002<\/p>\n<p class=\"ds-markdown-paragraph\">\u4e0b\u9762\u7684\u8868\u683c\u603b\u7ed3\u4e86\u5173\u952e\u7684\u5206\u5316\u6807\u5fd7\u7269\uff1a<\/p>\n<div class=\"ds-scroll-area _1210dd7 c03cafe9\">\n<table>\n<thead>\n<tr>\n<th><strong>\u5206\u5316\u9636\u6bb5\/\u7ec6\u80de\u7c7b\u578b<\/strong><\/th>\n<th><strong>\u5173\u952e\u6807\u5fd7\u7269<\/strong><\/th>\n<th><strong>\u529f\u80fd\u610f\u4e49<\/strong><\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><strong>\u795e\u7ecf\u5e72\u7ec6\u80de\/\u524d\u4f53\u7ec6\u80de<\/strong><\/td>\n<td><strong>\u5de2\u86cb\u767d<\/strong>,<strong>Sox2<\/strong>,<strong>Musashi1<\/strong><\/td>\n<td>\u6807\u5fd7\u672a\u5206\u5316\u72b6\u6001\u4e0e\u81ea\u6211\u66f4\u65b0\u80fd\u529b<\/td>\n<\/tr>\n<tr>\n<td><strong>\u65e9\u671f\u795e\u7ecf\u5143\/\u795e\u7ecf\u7956\u7ec6\u80de<\/strong><\/td>\n<td><strong>\u03b2-III\u5fae\u7ba1\u86cb\u767d<\/strong>,<strong>Doublecortin<\/strong><\/td>\n<td>\u6807\u5fd7\u795e\u7ecf\u5143\u8c31\u7cfb\u627f\u8bfa\u548c\u8fc1\u79fb\u8fc7\u7a0b<\/td>\n<\/tr>\n<tr>\n<td><strong>\u6210\u719f\u795e\u7ecf\u5143<\/strong><\/td>\n<td><strong>NeuN<\/strong>,<strong>\u5fae\u7ba1\u76f8\u5173\u86cb\u767d2<\/strong>,<strong>\u7a81\u89e6\u7d20<\/strong><\/td>\n<td>\u6807\u5fd7\u795e\u7ecf\u5143\u6210\u719f\u4e0e\u529f\u80fd\u7a81\u89e6\u5f62\u6210<\/td>\n<\/tr>\n<tr>\n<td><strong>\u661f\u5f62\u80f6\u8d28\u7ec6\u80de<\/strong><\/td>\n<td><strong>\u80f6\u8d28\u7ea4\u7ef4\u9178\u6027\u86cb\u767d<\/strong>,<strong>S100\u03b2<\/strong><\/td>\n<td>\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u7684\u5178\u578b\u4e2d\u95f4\u4e1d\u86cb\u767d<\/td>\n<\/tr>\n<tr>\n<td><strong>\u5c11\u7a81\u80f6\u8d28\u7ec6\u80de<\/strong><\/td>\n<td><strong>\u9ad3\u9798\u78b1\u6027\u86cb\u767d<\/strong>,<strong>O4<\/strong>,<strong>\u5c11\u7a81\u80f6\u8d28\u7ec6\u80de\u8f6c\u5f55\u56e0\u5b502<\/strong><\/td>\n<td>\u6807\u5fd7\u5c11\u7a81\u80f6\u8d28\u7ec6\u80de\u6210\u719f\u4e0e\u9ad3\u9798\u5f62\u6210<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<h2><span class=\"ez-toc-section\" id=\"06_%E4%BD%93%E5%A4%96%E5%9F%B9%E5%85%BB%E7%9A%84%E5%9F%BA%E7%9F%B3%EF%BC%9A%E7%A5%9E%E7%BB%8F%E5%B9%B2%E7%BB%86%E8%83%9E%E5%88%86%E5%8C%96%E5%9F%B9%E5%85%BB%E5%9F%BA\"><\/span>06 \u4f53\u5916\u57f9\u517b\u7684\u57fa\u77f3\uff1a\u795e\u7ecf\u5e72\u7ec6\u80de\u5206\u5316\u57f9\u517b\u57fa<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p class=\"ds-markdown-paragraph\"><strong>\u5206\u5316\u57f9\u517b\u57fa<\/strong>\u662f\u4f53\u5916\u5f15\u5bfcNSCs\u547d\u8fd0\u7684\u201c\u6307\u6325\u68d2\u201d\u3002\u5176\u6210\u5206\u7ecf\u8fc7\u7cbe\u5fc3\u8bbe\u8ba1\uff0c\u65e8\u5728\u63d0\u4f9b\u5206\u5316\u7684\u9a71\u52a8\u529b\u5e76\u6291\u5236\u975e\u76ee\u6807\u8def\u5f84\u3002<\/p>\n<ul>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>\u57fa\u7840\u57f9\u517b\u57fa<\/strong>\uff1a\u901a\u5e38\u4e3aDMEM\/F12\u7b49\uff0c\u63d0\u4f9b\u57fa\u672c\u8425\u517b\u3002<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>\u5173\u952e\u6dfb\u52a0\u5242<\/strong>::<\/p>\n<ul>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>\u65e0\u8840\u6e05\u6dfb\u52a0\u5242<\/strong>\uff1a\u5982B27\u4e0eN2\uff0c\u63d0\u4f9b\u8102\u8d28\u3001\u6fc0\u7d20\u3001\u6297\u6c27\u5316\u5242\u7b49\u795e\u7ecf\u8425\u517b\u652f\u6301\uff0c\u662f\u8bf1\u5bfc\u548c\u7ef4\u6301\u795e\u7ecf\u5206\u5316\u7684\u6838\u5fc3\u3002<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>\u751f\u957f\u56e0\u5b50\u4e0e\u7ec6\u80de\u56e0\u5b50<\/strong>::<\/p>\n<ul>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>bFGF<\/strong>\uff1a\u5e38\u7528\u4e8e\u7ef4\u6301NSCs\u7684\u589e\u6b96\u3002<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>EGF<\/strong>\uff1a\u4fc3\u8fdbNSCs\u7684\u589e\u6b96\u3002<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>BDNF<\/strong>,<strong>GDNF<\/strong>\uff1a\u5f3a\u529b\u4fc3\u8fdb\u795e\u7ecf\u5143\u5b58\u6d3b\u3001\u6210\u719f\u4e0e\u7a81\u89e6\u5f62\u6210\u3002<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>CNTF<\/strong>,<strong>LIF<\/strong>\uff1a\u53ef\u8bf1\u5bfc\u5411\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u5206\u5316\u3002<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>\u7532\u72b6\u817a\u6fc0\u7d20T3<\/strong>,<strong>\u89c6\u9ec4\u9178<\/strong>\uff1a\u662f\u9a71\u52a8\u5c11\u7a81\u80f6\u8d28\u7ec6\u80de\u5206\u5316\u548c\u6210\u719f\u7684\u5f3a\u6548\u8bf1\u5bfc\u5242\u3002<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>\u5c0f\u5206\u5b50\u5316\u5408\u7269<\/strong>\uff1a\u5229\u7528\u5c0f\u5206\u5b50\u836f\u7269\u7279\u5f02\u6027\u6fc0\u6d3b\u6216\u6291\u5236\u5173\u952e\u4fe1\u53f7\u901a\u8def\uff08\u5982Notch\u3001BMP\u3001Wnt\u7b49\uff09\uff0c\u5df2\u6210\u4e3a\u5b9e\u73b0\u9ad8\u6548\u3001\u540c\u6b65\u5206\u5316\u7684\u524d\u6cbf\u7b56\u7565\u3002<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<hr \/>\n<p class=\"ds-markdown-paragraph\">\u4ece\u7406\u89e3\u5927\u8111\u53d1\u80b2\u7684\u5965\u79d8\uff0c\u5230\u4e3a\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u3001\u5e15\u91d1\u68ee\u75c5\u3001\u810a\u9ad3\u635f\u4f24\u7b49\u987d\u75be\u63d0\u4f9b\u6f5c\u5728\u7684\u7ec6\u80de\u66ff\u4ee3\u7597\u6cd5\uff0c\u5bf9<strong>\u795e\u7ecf\u5e72\u7ec6\u80de\u5206\u5316<\/strong>\u7684\u6df1\u5165\u7814\u7a76\u662f\u8fd9\u4e00\u5207\u7684\u57fa\u77f3\u3002<\/p>\n<p class=\"ds-markdown-paragraph\">\u968f\u7740\u57fa\u56e0\u7f16\u8f91\u6280\u672f\uff08\u5982CRISPR\/Cas9\uff09\u4e0e\u751f\u7269\u6750\u6599\u3001\u7ec4\u7ec7\u5de5\u7a0b\u7684\u878d\u5408\uff0c\u6211\u4eec\u6b63\u671d\u7740<strong>\u7cbe\u51c6\u8c03\u63a7\u5206\u5316\u547d\u8fd0\u3001\u5b9a\u5236\u4e2a\u6027\u5316\u795e\u7ecf\u7ec6\u80de<\/strong>\u7684\u65f6\u4ee3\u8fc8\u8fdb\u3002<\/p>\n<p class=\"ds-markdown-paragraph\">\u672a\u6765\uff0c\u6211\u4eec\u6216\u8bb8\u4e0d\u4ec5\u80fd\u4fee\u590d\u53d7\u635f\u7684\u795e\u7ecf\u56de\u8def\uff0c\u66f4\u80fd\u6df1\u5165\u7406\u89e3\u4eba\u7c7b\u667a\u6167\u4e0e\u610f\u8bc6\u7684\u7ec6\u80de\u8d77\u6e90\u3002<\/p>","protected":false},"excerpt":{"rendered":"<p>\u5927\u8111\u5185\u7684\u6bcf\u4e00\u6b21\u4fee\u590d\u4e0e\u91cd\u5851\uff0c\u90fd\u59cb\u4e8e\u4e00\u573a\u9759\u9ed8\u800c\u7cbe\u5bc6\u7684\u7ec6\u80de\u5206\u5316\u4e4b\u65c5\u3002 \u5728\u795e\u7ecf\u79d1\u5b66\u548c\u518d\u751f\u533b\u5b66\u9886\u57df\uff0c\u795e\u7ecf\u5e72\u7ec6\u80de\u5206\u5316\u662f\u4e00\u4e2a [&hellip;]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[73],"tags":[165],"_links":{"self":[{"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/posts\/20413"}],"collection":[{"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/comments?post=20413"}],"version-history":[{"count":3,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/posts\/20413\/revisions"}],"predecessor-version":[{"id":20418,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/posts\/20413\/revisions\/20418"}],"wp:attachment":[{"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/media?parent=20413"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/categories?post=20413"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/tags?post=20413"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}