{"id":20419,"date":"2025-11-12T17:18:52","date_gmt":"2025-11-12T09:18:52","guid":{"rendered":"https:\/\/www.hjtdsm.cn\/?p=20419"},"modified":"2025-11-12T17:19:31","modified_gmt":"2025-11-12T09:19:31","slug":"%e5%a4%9a%e8%83%bd%e5%b9%b2%e7%bb%86%e8%83%9e%e6%b2%bb%e7%96%97%e9%bb%84%e6%96%91%e5%8f%98%e6%80%a7","status":"publish","type":"post","link":"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/psc\/20419.html","title":{"rendered":"\u591a\u80fd\u5e72\u7ec6\u80de\u6cbb\u7597\u9ec4\u6591\u53d8\u6027\u53ca\u5176\u4ed6\u773c\u75c5\u7684\u4e34\u5e8a\u7814\u7a76\u8fdb\u5c55"},"content":{"rendered":"<p class=\"ds-markdown-paragraph\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u89c6\u7f51\u819c\u8272\u7d20\u4e0a\u76ae\uff08RPE\uff09\u7ec6\u80de\u7684\u529f\u80fd\u969c\u788d\u6216\u4e27\u5931\u662f\u591a\u79cd\u9ec4\u6591\u53d8\u6027\u75be\u75c5\uff08\u5982\u5e74\u9f84\u76f8\u5173\u6027\u9ec4\u6591\u53d8\u6027\u3001Stargardt\u75c5\u7b49\uff09\u7684\u6838\u5fc3\u75c5\u7406\u673a\u5236\u3002 RPE\u4f5c\u4e3a\u4e00\u5c42\u5177\u6709\u591a\u79cd\u5173\u952e\u529f\u80fd\u7684\u5355\u5c42\u7ec6\u80de\uff0c\u4e0d\u4ec5\u4e3a\u611f\u5149\u7ec6\u80de\u63d0\u4f9b\u8425\u517b\u652f\u6301\uff0c\u8fd8\u53c2\u4e0e\u89c6\u9ec4\u919b\u4ee3\u8c22\u548c\u541e\u566c\u611f\u5149\u7ec6\u80de\u5916\u8282\u76d8\u819c\u3002\u5176\u635f\u4f24\u5c06\u76f4\u63a5\u5bfc\u81f4\u611f\u5149\u7ec6\u80de\u9000\u5316\u4e0e\u4e2d\u5fc3\u89c6\u529b\u4e27\u5931\u3002\u8fd1\u5e74\u6765\uff0c\u57fa\u4e8e\u4eba\u591a\u80fd\u5e72\u7ec6\u80de\u6cbb\u7597\u9ec4\u6591\u53d8\u6027\u7684\u76f8\u5173\u7814\u7a76\u4e3a\u8fd9\u7c7b\u75be\u75c5\u63d0\u4f9b\u4e86\u65b0\u7684\u6cbb\u7597\u601d\u8def\uff0c\u5e76\u5df2\u8fdb\u5165\u4e34\u5e8a\u63a2\u7d22\u9636\u6bb5\u3002<\/span><\/span><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-20424 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/istockphoto-963177108-612x612-1.jpg\" alt=\"\u591a\u80fd\u5e72\u7ec6\u80de\u6cbb\u7597\u9ec4\u6591\u53d8\u6027\u53ca\u5176\u4ed6\u773c\u75c5\u7684\u4e34\u5e8a\u7814\u7a76\u8fdb\u5c55\" width=\"593\" height=\"612\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/istockphoto-963177108-612x612-1.jpg 593w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/istockphoto-963177108-612x612-1-291x300.jpg 291w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/istockphoto-963177108-612x612-1-12x12.jpg 12w\" sizes=\"(max-width: 593px) 100vw, 593px\" \/><\/p>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_79_2 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewbox=\"0 0 24 24\" version=\"1.2\" baseprofile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1' ><ul class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/psc\/20419.html\/#hPSC%E6%9D%A5%E6%BA%90%E7%9A%84RPE%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E7%AD%96%E7%95%A5\" >hPSC\u6765\u6e90\u7684RPE\u7ec6\u80de\u6cbb\u7597\u7b56\u7565<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/psc\/20419.html\/#2025%E5%B9%B4%E5%A4%9A%E8%83%BD%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E9%BB%84%E6%96%91%E5%8F%98%E6%80%A7%E5%8F%8A%E5%85%B6%E4%BB%96%E7%9C%BC%E7%97%85%E7%9A%84%E4%B8%B4%E5%BA%8A%E7%A0%94%E7%A9%B6%E8%BF%9B%E5%B1%95\" >2025\u5e74\u591a\u80fd\u5e72\u7ec6\u80de\u6cbb\u7597\u9ec4\u6591\u53d8\u6027\u53ca\u5176\u4ed6\u773c\u75c5\u7684\u4e34\u5e8a\u7814\u7a76\u8fdb\u5c55<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/psc\/20419.html\/#1_%E5%B9%B2%E6%80%A7%E5%B9%B4%E9%BE%84%E7%9B%B8%E5%85%B3%E6%80%A7%E9%BB%84%E6%96%91%E5%8F%98%E6%80%A7%EF%BC%88Dry_AMD%EF%BC%89%E4%B8%8EStargardt%E7%97%85%EF%BC%88SMD%EF%BC%89\" >1. \u5e72\u6027\u5e74\u9f84\u76f8\u5173\u6027\u9ec4\u6591\u53d8\u6027\uff08Dry AMD\uff09\u4e0eStargardt\u75c5\uff08SMD\uff09<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/psc\/20419.html\/#2_%E6%B9%BF%E6%80%A7%E5%B9%B4%E9%BE%84%E7%9B%B8%E5%85%B3%E6%80%A7%E9%BB%84%E6%96%91%E5%8F%98%E6%80%A7%EF%BC%88Wet_AMD%EF%BC%89\" >2. \u6e7f\u6027\u5e74\u9f84\u76f8\u5173\u6027\u9ec4\u6591\u53d8\u6027\uff08Wet AMD\uff09<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/psc\/20419.html\/#3_%E5%85%B6%E4%BB%96%E7%9C%BC%E7%A7%91%E7%96%BE%E7%97%85\" >3. \u5176\u4ed6\u773c\u79d1\u75be\u75c5<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/psc\/20419.html\/#%E6%8A%80%E6%9C%AF%E6%8C%91%E6%88%98%E4%B8%8E%E6%9C%AA%E6%9D%A5%E6%96%B9%E5%90%91\" >\u6280\u672f\u6311\u6218\u4e0e\u672a\u6765\u65b9\u5411<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/psc\/20419.html\/#%E6%80%BB%E7%BB%93%E4%B8%8E%E5%B1%95%E6%9C%9B\" >Summary and outlook<\/a><\/li><\/ul><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"hPSC%E6%9D%A5%E6%BA%90%E7%9A%84RPE%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E7%AD%96%E7%95%A5\"><\/span><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">hPSC\u6765\u6e90\u7684RPE\u7ec6\u80de\u6cbb\u7597\u7b56\u7565<\/span><\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p class=\"ds-markdown-paragraph\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">hPSC\u4e3b\u8981\u5305\u62ec<\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u80da\u80ce\u5e72\u7ec6\u80de\uff08human embryonic stem cells, hESCs\uff09<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u00a0\u4e0e<\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de\uff08induced pluripotent stem cells, iPSCs\uff09<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u3002\u5b83\u4eec\u80fd\u591f\u5206\u5316\u4e3aRPE\u7ec6\u80de\uff0c\u5e76\u901a\u8fc7\u4ee5\u4e0b\u5f62\u5f0f\u8fdb\u884c\u79fb\u690d\uff1a<\/span><\/span><\/p>\n<ol start=\"1\">\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7ec6\u80de\u60ac\u6db2\u79fb\u690d<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff1a\u901a\u8fc7\u89c6\u7f51\u819c\u4e0b\u6ce8\u5c04\u8f93\u9001hPSC\u6765\u6e90\u7684RPE\u7ec6\u80de\u3002<\/span><\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7ec6\u80de\u7247\u5c42\u79fb\u690d<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff1a\u5c06RPE\u7ec6\u80de\u5728\u53ef\u964d\u89e3\u6216\u975e\u964d\u89e3\u652f\u67b6\u4e0a\u57f9\u517b\u6210\u5355\u5c42\u540e\u690d\u5165\uff0c\u4f8b\u5982\u57fa\u4e8e\u805a\u4e73\u9178-\u7f9f\u57fa\u4e59\u9178\uff08PLGA\uff09\u652f\u67b6\u7684RPE\u5355\u5c42\uff0c\u6216\u4f7f\u7528ORMOCER\u00ae\u7b49\u6750\u6599\u4f5c\u4e3a\u8f7d\u4f53\u819c\u3002<\/span><\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u590d\u5408\u79fb\u690d<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff1a\u5c1d\u8bd5\u79fb\u690dRPE-\u8109\u7edc\u819c\u590d\u5408\u7269\u6216\u89c6\u7f51\u819c\u7c7b\u5668\u5b98\u7247\u3002<\/span><\/span><\/p>\n<\/li>\n<\/ol>\n<h1><span class=\"ez-toc-section\" id=\"2025%E5%B9%B4%E5%A4%9A%E8%83%BD%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E9%BB%84%E6%96%91%E5%8F%98%E6%80%A7%E5%8F%8A%E5%85%B6%E4%BB%96%E7%9C%BC%E7%97%85%E7%9A%84%E4%B8%B4%E5%BA%8A%E7%A0%94%E7%A9%B6%E8%BF%9B%E5%B1%95\"><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">2025\u5e74\u591a\u80fd\u5e72\u7ec6\u80de\u6cbb\u7597\u9ec4\u6591\u53d8\u6027\u53ca\u5176\u4ed6\u773c\u75c5\u7684\u4e34\u5e8a\u7814\u7a76\u8fdb\u5c55<\/span><\/span><\/strong><span class=\"ez-toc-section-end\"><\/span><\/h1>\n<h3><span class=\"ez-toc-section\" id=\"1_%E5%B9%B2%E6%80%A7%E5%B9%B4%E9%BE%84%E7%9B%B8%E5%85%B3%E6%80%A7%E9%BB%84%E6%96%91%E5%8F%98%E6%80%A7%EF%BC%88Dry_AMD%EF%BC%89%E4%B8%8EStargardt%E7%97%85%EF%BC%88SMD%EF%BC%89\"><\/span><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">1. \u5e72\u6027\u5e74\u9f84\u76f8\u5173\u6027\u9ec4\u6591\u53d8\u6027\uff08Dry AMD\uff09\u4e0eStargardt\u75c5\uff08SMD\uff09<\/span><\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p class=\"ds-markdown-paragraph\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5e72\u6027AMD\u7684\u5730\u7406\u840e\u7f29\uff08GA\uff09\u9636\u6bb5\u53caSMD\u76ee\u524d\u5747<\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7f3a\u4e4f\u6709\u6548\u6cbb\u7597\u65b9\u6cd5<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff0c\u56e0\u6b64\u6210\u4e3ahPSC-RPE\u7597\u6cd5\u7684\u91cd\u8981\u7814\u7a76\u65b9\u5411\u3002<\/span><\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u65e9\u671f\u4e34\u5e8a\u5c1d\u8bd5<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff1a2011\u5e74\uff0c<\/span><\/span><a href=\"https:\/\/www.thelancet.com\/journals\/lancet\/article\/PIIS0140-6736(12)60028-2\/abstract\" rel=\"nofollow noopener\" target=\"_blank\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7f8e\u56fdAdvanced Cell Technology<\/span><\/span><\/a><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff08\u540e\u4e3aOcata Therapeutics\uff09\u6700\u65e9\u5f00\u5c55hESC\u6765\u6e90RPE\u7ec6\u80de\uff08MA09-hRPE\uff09\u60ac\u6db2\u6cbb\u7597SMD\uff08NCT01345006\uff09\u4e0e\u5e72\u6027AMD\uff08NCT01344993\uff09\u7684\u4e34\u5e8a\u8bd5\u9a8c\u3002\u90e8\u5206\u60a3\u8005\u89c6\u529b\u63d0\u534710\u201315\u4e2a\u5b57\u6bcd\uff0c\u4f46\u7814\u7a76\u8005\u6307\u51fa\u665a\u671f\u60a3\u8005\u89c6\u529b\u8bc4\u4f30\u53ef\u9760\u6027\u6709\u9650\u3002<\/span><\/span><\/p>\n<div id=\"attachment_20421\" style=\"width: 906px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-20421\" class=\"wp-image-20421 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-12_163350_907.png\" alt=\"\" width=\"896\" height=\"289\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-12_163350_907.png 896w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-12_163350_907-300x97.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-12_163350_907-768x248.png 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-12_163350_907-18x6.png 18w\" sizes=\"(max-width: 896px) 100vw, 896px\" \/><p id=\"caption-attachment-20421\" class=\"wp-caption-text\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u80da\u80ce\u5e72\u7ec6\u80de\u6cbb\u7597\u9ec4\u6591\u53d8\u6027\u7684\u8bd5\u9a8c\uff1a\u521d\u6b65\u62a5\u544a<\/span><\/span><\/p><\/div>\n<p class=\"ds-markdown-paragraph\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u540e\u7eed<\/span><\/span><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff0c\u82f1\u56fd\u542f\u52a8\u4e86\u4e00\u9879\u9488\u5bf9SMD\u7684MA09-hRPE\u7684\u989d\u5916\u8bd5\u9a8c\uff08NCT01469832\uff09\u3002\u8be5\u8bd5\u9a8c\u5bf9\u89c6\u7f51\u819c\u7ed3\u6784\u548c\u529f\u80fd\u7684\u7a7a\u95f4\u76f8\u5173\u6027\u8fdb\u884c\u4e86\u66f4\u8be6\u7ec6\u7684\u5206\u6790\uff0c\u4f4612\u4e2a\u6708\u65f6\uff0c\u6240\u6709\u63a5\u53d7\u6cbb\u7597\u7684\u60a3\u8005\u5747\u672a\u53d1\u73b0\u663e\u7740\u83b7\u76ca\uff0c\u8fd9\u53ef\u80fd\u662f\u7531\u4e8e\u7eb3\u5165\u7814\u7a76\u7684\u60a3\u8005\u75c5\u60c5\u5df2\u53d1\u5c55\u5230\u665a\u671f\u3002<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">2015\u5e74\uff0c<\/span><\/span><a href=\"https:\/\/www.cell.com\/stem-cell-reports\/fulltext\/S2213-6711(15)00105-8?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2213671115001058%3Fshowall%3Dtrue\" target=\"_blank\" rel=\"noopener nofollow\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u97e9\u56fdCHABiotech\u516c\u53f8\u4e5f\u8fdb\u884c\u4e86MA09-hRPE\u4e34\u5e8a\u8bd5\u9a8c<\/span><\/span><\/a><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff0c\u5728SMD\u60a3\u8005\u4e2d\u89c2\u5bdf\u523012\u81f319\u4e2a\u5b57\u6bcd\u7684\u6539\u5584\uff08NCT01625559\uff09\uff0c\u5728\u5e72\u6027AMD\u60a3\u8005\u4e2d\u63d0\u53471\u20139\u4e2a\u5b57\u6bcd\uff08NCT01674829\uff09\u3002\u7136\u800c\uff0c\u672a\u6cbb\u7597\u7684\u5bf9\u4fa7SMD\u773c\u4ea6\u63d0\u5347\u4e869\u4e2a\u5b57\u6bcd\uff0c\u800c\u672a\u6cbb\u7597\u7684AMD\u773c\u53cd\u800c\u4e0b\u964d6\u81f320\u4e2a\u5b57\u6bcd\uff0c\u63d0\u793a\u9700\u8c28\u614e\u89e3\u8bfb\u8fd9\u4e9b\u6539\u5584\u7ed3\u679c\u3002<\/span><\/span><\/p>\n<div id=\"attachment_20422\" style=\"width: 1142px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-20422\" class=\"wp-image-20422 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-12_164238_091.png\" alt=\"\" width=\"1132\" height=\"353\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-12_164238_091.png 1132w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-12_164238_091-300x94.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-12_164238_091-1024x319.png 1024w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-12_164238_091-768x239.png 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-12_164238_091-18x6.png 18w\" sizes=\"(max-width: 1132px) 100vw, 1132px\" \/><p id=\"caption-attachment-20422\" class=\"wp-caption-text\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5229\u7528\u80da\u80ce\u5e72\u7ec6\u80de\u884d\u751f\u7684\u89c6\u7f51\u819c\u8272\u7d20\u4e0a\u76ae\u6cbb\u7597\u9ec4\u6591\u53d8\u6027\uff1a\u4e9a\u6d32\u60a3\u8005\u7684\u521d\u6b65\u7ed3\u679c<\/span><\/span><\/p><\/div>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">2015\u5e74\uff0cCell Cure Neurosciences\uff08Lineage Cell Therapeutics\u5b50\u516c\u53f8\uff09\u5f00\u53d1\u7684OpRegen\u4ea7\u54c1\u8fdb\u5165\u4e34\u5e8a\u3002\u8be5\u4ea7\u54c1\u4e3a\u51b7\u51bb\u4fdd\u5b58\u7684hESC\u884d\u751fRPE\u7ec6\u80de\u60ac\u6db2\uff0c<\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7ecf\u73bb\u7483\u4f53\u5207\u9664\u672f\u53ca\u89c6\u7f51\u819c\u5207\u5f00\u6216\u7ecf\u8109\u7edc\u819c\u4e0a\u8154\u9014\u5f84\u6ce8\u5165\u89c6\u7f51\u819c\u4e0b\u8154\uff08NCT02286089\uff09\u3002\u7ed3\u679c\u663e\u793a\uff0c\u91cd\u5ea6\u89c6\u529b\u635f\u5bb3\u60a3\u8005\u75c5\u7a0b\u4ecd\u5448\u8fdb\u5c55\uff0c\u4f46\u8f7b\u5ea6\u60a3\u8005\u7684\u89c6\u529b\u53ef\u7ef4\u6301\u6216\u6539\u5584\uff08-2\u81f3+24\u4e2a\u5b57\u6bcd\uff09\uff0c\u8bf4\u660e\u5728\u75be\u75c5\u65e9\u671f\u60a3\u8005\u4e2d\u5b9e\u73b0\u7597\u6548\u66f4\u4e3a\u53ef\u884c<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u3002 2023\u5e74\uff0c\u8be5\u4ea7\u54c1\u7684II\u671f\u8bd5\u9a8c\uff08NCT05626114\uff09\u5df2\u542f\u52a8\u3002<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u540c\u5e74\uff0c\u4e2d\u56fd\u897f\u5357\u533b\u9662\u5f00\u5c55\u4e86\u4e00\u9879\u672a\u51b7\u51bb\u4fdd\u5b58\u7684RPE\u7ec6\u80de\u6cbb\u7597SMD\u7684\u7814\u7a76\uff08NCT02749734\uff09\u3002\u7814\u7a76\u4f18\u5316\u4e86\u7ec6\u80de\u9012\u9001\u65b9\u5f0f\uff0c\u4ee5\u907f\u514d\u7ec6\u80de\u5f25\u6563\u81f3\u73bb\u7483\u4f53\u8154\u5e76\u5f15\u53d1RPE\u66b4\u9732\u4e8e\u7ec6\u80de\u56e0\u5b50\u540e\u5bfc\u81f4\u7684\u589e\u6b96\u6027\u73bb\u7483\u4f53\u89c6\u7f51\u819c\u75c5\u53d8\u3002\u7ed3\u679c\u663e\u793a\uff0c<\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u672f\u540e1\u20134\u4e2a\u6708\u89c6\u529b\u7a33\u5b9a\u6216\u77ed\u6682\u63d0\u5347\uff0c\u4f46\u81f360\u4e2a\u6708\u65f6\u67093\u4f8b\u60a3\u8005\u51fa\u73b0\u89c6\u529b\u4e0b\u964d<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u3002 2015\u5e74\uff0c\u5df4\u897f\u5723\u4fdd\u7f57\u5927\u5b66\u542f\u52a8\u4e86\u4e00\u9879\u6bd4\u8f83RPE\u5355\u5c42\u79fb\u690d\u4e0e\u60ac\u6db2\u79fb\u690d\u7684\u7814\u7a76\uff08NCT02903576\uff09\uff0c\u7ed3\u679c\u5c1a\u672a\u516c\u5e03\uff0c\u4ec5\u5728SMD\u60a3\u8005\u4e2d\u89c2\u5bdf\u5230\u975e\u663e\u7740\u6027\u89c6\u529b\u63d0\u5347\u3002<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">2016\u5e74\uff0cRegenerative Patch Technologies\u516c\u53f8\u5c06hESC\u884d\u751fRPE\u4ee5\u975e\u51b7\u51bb\u4fdd\u5b58\u7684\u7ec6\u80de\u7247\u5f62\u5f0f\u690d\u5165\u5e72\u6027AMD\u60a3\u8005\uff08NCT02590692\uff09\u3002\u8fd9\u79cd\u57fa\u4e8e\u652f\u67b6\u7684\u7ec6\u80de\u5c42\u53ef\u6a21\u62dfBruch\u819c\u7684\u652f\u6301\u529f\u80fd\uff0c\u4ece\u800c\u63d0\u9ad8\u79fb\u690d\u7ec6\u80de\u7684\u5b58\u6d3b\u4e0e\u529f\u80fd\u3002<\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">16\u540d\u53d7\u8bd5\u8005\u4e2d\uff0c4\u540d\u572812\u4e2a\u6708\u540e\u89c6\u529b\u63d0\u5347\u8d85\u8fc75\u4e2a\u5b57\u6bcd<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u3002\u5c38\u68c0\u968f\u8bbf\u7ed3\u679c\u663e\u793a\uff0c\u79fb\u690d\u7269\u57282\u5e74\u540e\u4ecd\u5b58\u6d3b\uff0c\u4e14\u65e0\u660e\u663e\u708e\u75c7\u6216\u514d\u75ab\u6392\u65a5\u53cd\u5e94\u3002 3\u5e74\u4e2d\u4f4d\u968f\u8bbf\u663e\u793a\uff0c\u79fb\u690d\u773c\u6539\u5584\u8d85\u8fc75\u4e2a\u5b57\u6bcd\u7684\u6bd4\u4f8b\u8f83\u9ad8\uff0c\u4f46\u6837\u672c\u91cf\u4e0d\u8db3\u4ee5\u8fbe\u5230\u7edf\u8ba1\u5b66\u663e\u7740\u6027\u3002<\/span><\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7ec6\u80de\u7247\u5c42\/\u652f\u67b6\u6280\u672f\u7a81\u7834<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff1a\u7f8e\u56fdNIH\u56fd\u5bb6\u773c\u79d1\u7814\u7a76\u6240\u7684Kapil Bharti\u56e2\u961f\u5f00\u5c55\u4e86\u57fa\u4e8e<\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u81ea\u4f53iPSC-RPE<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u00a0\u7684I\/IIa\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08NCT04339764\uff09\u3002\u8be5\u7814\u7a76\u4f7f\u7528\u53ef\u751f\u7269\u964d\u89e3\u7684PLGA\u652f\u67b6\uff0c\u5c06\u60a3\u8005\u81ea\u4f53iPSC\u6765\u6e90\u7684RPE\u5355\u5c42\u79fb\u690d\u81f3\u89c6\u7f51\u819c\u4e0b\u7a7a\u95f4\uff0c\u65e8\u5728\u8bc4\u4f30\u5176\u5b89\u5168\u6027\u4e0e\u53ef\u884c\u6027\u3002<\/span><\/span><\/p>\n<p><a href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/20358.html\/\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">2025\u5e74\uff0cRPESC-RPE\u7ec6\u80de\u6cbb\u7597\u5e72\u6027AMD\u7684\u65e9\u671f\u4e34\u5e8a\u7ed3\u679c\uff1a\u5b89\u5168\u6027\u826f\u597d\u5e76\u663e\u73b0\u89c6\u529b\u6539\u5584\u4fe1\u53f7<\/span><\/span><\/a><\/p>\n<h3><span class=\"ez-toc-section\" id=\"2_%E6%B9%BF%E6%80%A7%E5%B9%B4%E9%BE%84%E7%9B%B8%E5%85%B3%E6%80%A7%E9%BB%84%E6%96%91%E5%8F%98%E6%80%A7%EF%BC%88Wet_AMD%EF%BC%89\"><\/span><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">2. \u6e7f\u6027\u5e74\u9f84\u76f8\u5173\u6027\u9ec4\u6591\u53d8\u6027\uff08Wet AMD\uff09<\/span><\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p class=\"ds-markdown-paragraph\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6e7f\u6027\uff08\u65b0\u751f\u8840\u7ba1\u6027\uff09AMD\u7684\u6807\u51c6\u6cbb\u7597\u4e3a\u6297VEGF\u6297\u4f53\u6291\u5236\u5f02\u5e38\u8840\u7ba1\u751f\u6210\uff0c\u6548\u679c\u663e\u7740\uff0c\u4f46\u65e0\u6cd5\u9006\u8f6cRPE\u9000\u5316\u3002\u76ee\u524d\uff0c\u57fa\u4e8ehPSC\u6765\u6e90\u7684RPE\u7ec6\u80de\u60ac\u6db2\u53ca\u7ec6\u80de\u7247\u7597\u6cd5\u5747\u5728\u6e7f\u6027AMD\u4e34\u5e8a\u4e2d\u63a2\u7d22\u3002 \u9996\u4e2ahiPSC\u6765\u6e90\u7ec6\u80de\u6cbb\u7597\u8bd5\u9a8c\u4e8e2013\u5e74\u7531\u65e5\u672c\u7406\u5316\u5b66\u7814\u7a76\u6240\u7684\u9ad8\u6865\u653f\u4ee3\uff08Masayo Takahashi\uff09\u53d1\u8d77\uff08UMIN000011929\uff09\u3002\u8be5\u7814\u7a76\u5c06\u81ea\u4f53hiPSC\u884d\u751fRPE\u7ec6\u80de\u7247\uff081.3\u00d73 mm\uff09\u690d\u5165\u4e00\u540d\u6e7f\u6027AMD\u60a3\u8005\u773c\u5185\uff0c\u672a\u4f7f\u7528\u514d\u75ab\u6291\u5236\u5242\u3002\u7ed3\u679c\u663e\u793a\uff0c4\u5e74\u540e\u79fb\u690d\u7269\u4ecd\u5b58\u6d3b\uff0c\u4e14\u57281\u5e74\u4e0e4\u5e74\u65f6\u89c6\u529b\u7a33\u5b9a\uff0c\u65e0\u9700\u989d\u5916\u6297VEGF\u6cbb\u7597\u3002<\/span><\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">2015\u5e74\uff0c\u82f1\u56fdMoorfields\u773c\u79d1\u533b\u9662\u7684Pete Coffey\u56e2\u961f\u5728\u4e24\u540d\u60a3\u8005\u4e2d\u690d\u5165\u4e86\u805a\u916f\u819c\u652f\u6491\u7684RPE\u5355\u5c42\uff08NCT01691261\uff09\u3002\u4e24\u540d\u60a3\u800512\u4e2a\u6708\u540e\u5747\u63d0\u5347\u8d85\u8fc720\u4e2a\u5b57\u6bcd\uff0c\u663e\u793ahPSC\u4ea7\u54c1\u7684\u660e\u786e\u7597\u6548\u3002\u7136\u800c5\u5e74\u540e\uff0c\u4e00\u540d\u60a3\u8005\u89c6\u529b\u4e0b\u964d\u81f3\u6bd4\u57fa\u7ebf\u4f4e2\u4e2a\u5b57\u6bcd\uff0c\u53e6\u4e00\u540d\u4ecd\u8f83\u57fa\u7ebf\u9ad89\u4e2a\u5b57\u6bcd\uff0c\u63d0\u793a\u79fb\u690d\u7269\u53ef\u80fd\u90e8\u5206\u4e22\u5931\u3002\u79fb\u690d\u533a\u6301\u7eed\u8272\u7d20\u6c89\u7740\u7684\u89c2\u5bdf\u8868\u660e\uff0c\u79fb\u690d\u7269\u53ef\u80fd\u57285\u5e74\u540e\u4ecd\u5b58\u5728\u3002<\/span><\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1111\/cpr.13100\" target=\"_blank\" rel=\"noopener nofollow\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e2d\u56fd\u897f\u5357\u533b\u9662\u4ea6\u5728\u6e7f\u6027AMD\u60a3\u8005\u4e2d\u5e94\u7528\u4e0eSMD\u76f8\u540c\u7684RPE\u7ec6\u80de\u60ac\u6db2\u65b9\u6848\uff08NCT02749734\uff09<\/span><\/span><\/a><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff0c\u4f46\u6ce8\u5c04\u7ec6\u80de\u91cf\u63d0\u9ad8\u5341\u500d\uff08100\u4e07\/\u773c\uff09\uff0c3\u540d\u60a3\u8005\u5747\u51fa\u73b0\u89c6\u529b\u63d0\u5347\uff08\u589e\u52a011\u201326\u4e2a\u5b57\u6bcd\uff09\u3002<\/span><\/span><\/p>\n<div id=\"attachment_20423\" style=\"width: 722px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-20423\" class=\"wp-image-20423 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-12_170507_883.png\" alt=\"\" width=\"712\" height=\"343\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-12_170507_883.png 712w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-12_170507_883-300x145.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-12_170507_883-18x9.png 18w\" sizes=\"(max-width: 712px) 100vw, 712px\" \/><p id=\"caption-attachment-20423\" class=\"wp-caption-text\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e00\u9879\u5229\u7528\u4eba\u80da\u80ce\u5e72\u7ec6\u80de\u884d\u751f\u7684\u89c6\u7f51\u819c\u8272\u7d20\u4e0a\u76ae\u7ec6\u80de\u6cbb\u7597\u65e9\u671fStargardt\u9ec4\u6591\u53d8\u6027\u7684I\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff1a5\u5e74\u968f\u8bbf<\/span><\/span><\/p><\/div>\n<p class=\"ds-markdown-paragraph\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">2021\u5e74\uff0c\u9ad8\u6865\u653f\u4ee3\u56e2\u961f\u5728\u795e\u6237\u5e02\u773c\u79d1\u533b\u9662\u542f\u52a8\u4e86\u53e6\u4e00\u9879\u6e7f\u6027AMD\u7814\u7a76\uff08UMIN000026003\uff09\uff0c\u4f7f\u7528HLA\u5339\u914d\u7684\u540c\u79cd\u5f02\u4f53iPSC\u884d\u751fRPE\u60ac\u6db2\u4e14\u672a\u65bd\u514d\u75ab\u6291\u5236\u3002 5\u540d\u60a3\u8005\u4e2d\uff0c2\u540d\u63d0\u5347\u8d85\u8fc710\u4e2a\u5b57\u6bcd\uff0c3\u540d\u89c6\u529b\u7a33\u5b9a\uff0c\u968f\u8bbf1\u5e74\u786e\u8ba4\u79fb\u690d\u7269\u4ecd\u5b58\u6d3b\u3002<\/span><\/span><\/p>\n<h3><span class=\"ez-toc-section\" id=\"3_%E5%85%B6%E4%BB%96%E7%9C%BC%E7%A7%91%E7%96%BE%E7%97%85\"><\/span><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">3. \u5176\u4ed6\u773c\u79d1\u75be\u75c5<\/span><\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p class=\"ds-markdown-paragraph\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">hPSC\u7597\u6cd5\u4e5f\u9010\u6e10\u5e94\u7528\u4e8e\u5176\u4ed6\u773c\u79d1\u75be\u75c5\u7684\u6cbb\u7597\u63a2\u7d22\uff1a<\/span><\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8272\u7d20\u6027\u89c6\u7f51\u819c\u708e<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff1a\u6cd5\u56fd\uff08NCT03963154\uff09\u3001\u65e5\u672c\uff08jRCTa050200027\uff09\u53ca\u4e2d\u56fd\uff08NCT03944239\uff09\u5747\u6709\u7814\u7a76\u56e2\u961f\u5c1d\u8bd5hESC\u6216iPSC\u6765\u6e90\u7684\u89c6\u7f51\u819c\u7c7b\u5668\u5b98\u6216RPE\u7ec6\u80de\u7247\u79fb\u690d\uff0c\u90e8\u5206\u7814\u7a76\u663e\u793a\u79fb\u690d\u7ec6\u80de\u53ef\u5b58\u6d3b\uff0c\u4f46\u89c6\u529b\u6539\u5584\u6709\u9650\u3002<\/span><\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u89d2\u819c\u75be\u75c5<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff1a\u65e5\u672c\u5927\u962a\u5927\u5b66\u897f\u7530\u5e78\u53f8\u56e2\u961f\uff08UMIN000036539\uff09\u4f7f\u7528hiPSC\u884d\u751f\u89d2\u819c\u4e0a\u76ae\u7ec6\u80de\u7247\u6cbb\u7597\u89d2\u819c\u7f18\u5e72\u7ec6\u80de\u7f3a\u4e4f\u75c7\uff0c2\u5e74\u968f\u8bbf\u663e\u793a4\u4f8b\u60a3\u8005\u4e2d3\u4f8b\u75c7\u72b6\u6539\u5584\uff0c\u4e14\u65e0\u9700\u5168\u8eab\u514d\u75ab\u6291\u5236\u3002<\/span><\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u9488\u5bf9\u6c34\u75b1\u6027\u89d2\u819c\u75c5\u53d8\u7684\u89d2\u819c\u5185\u76ae\u7ec6\u80de\u79fb\u690d\u8bd5\u9a8c\uff08CLS001\uff09\u4e5f\u5df2\u542f\u52a8\u3002<\/span><\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u89c6\u7f51\u819c\u75c5\u53d8<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff1a\u52a0\u5dde\u5927\u5b66\u6234\u7ef4\u65af\u5206\u6821\uff08NCT01736059\uff09\u63a2\u7d22\u4e86\u81ea\u4f53\u9aa8\u9ad3CD34+\u5e72\u7ec6\u80de\u73bb\u7483\u4f53\u5185\u6ce8\u5c04\u6cbb\u7597\u89c6\u7f51\u819c\u75c5\u53d8\uff08\u5982\u7cd6\u5c3f\u75c5\u89c6\u7f51\u819c\u75c5\u53d8\u3001\u89c6\u7f51\u819c\u9759\u8109\u963b\u585e\uff09\u7684\u53ef\u884c\u6027\uff0c\u521d\u6b65\u7ed3\u679c\u663e\u793a\u5176\u5728\u5b89\u5168\u6027\u548c\u89c6\u529b\u6539\u5584\u65b9\u9762\u5177\u6709\u4e00\u5b9a\u6f5c\u529b\u3002<\/span><\/span><\/p>\n<h2><span class=\"ez-toc-section\" id=\"%E6%8A%80%E6%9C%AF%E6%8C%91%E6%88%98%E4%B8%8E%E6%9C%AA%E6%9D%A5%E6%96%B9%E5%90%91\"><\/span><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6280\u672f\u6311\u6218\u4e0e\u672a\u6765\u65b9\u5411<\/span><\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p class=\"ds-markdown-paragraph\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7ec6\u80de\u5236\u5907\u4e0e\u50a8\u5b58<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff1aiPSC\u5206\u5316RPE\u7684\u6548\u7387\u3001\u7a33\u5b9a\u6027\u53ca\u5927\u89c4\u6a21\u751f\u4ea7\u4ecd\u662f\u6311\u6218\u3002\u5f17\u52b3\u6069\u970d\u592b\u534f\u4f1a\u7684\u201cKryoRet\u201d\u9879\u76ee\u81f4\u529b\u4e8e\u4f18\u5316hiPSC\u6765\u6e90\u89c6\u7f51\u819c\u690d\u5165\u7269\u7684\u751f\u4ea7\u3001\u957f\u671f\u50a8\u5b58\u548c\u8fd0\u8f93\uff0c\u901a\u8fc7\u63a7\u5236\u51b7\u51bb\u8fc7\u7a0b\u548c\u673a\u5668\u5b66\u4e60\u8fdb\u884c\u8d28\u91cf\u63a7\u5236\u3002<\/span><\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u514d\u75ab\u6392\u65a5\u98ce\u9669<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff1a\u5c3d\u7ba1\u81ea\u4f53iPSC\u7406\u8bba\u4e0a\u53ef\u907f\u514d\u514d\u75ab\u6392\u65a5\uff0c\u4f46\u540c\u79cd\u5f02\u4f53\u79fb\u690d\uff08\u5982HLA\u5339\u914d\u7684iPSC\u4ea7\u54c1\uff09\u4ecd\u9700\u5173\u6ce8\u514d\u75ab\u53cd\u5e94\u3002\u591a\u6570\u8bd5\u9a8c\u672a\u62a5\u544a\u4e25\u91cd\u6392\u65a5\uff0c\u4f46\u957f\u671f\u5b89\u5168\u6027\u9700\u8fdb\u4e00\u6b65\u89c2\u5bdf\u3002<\/span><\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6700\u4f73\u79fb\u690d\u7b56\u7565<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff1a\u7ec6\u80de\u60ac\u6db2\u64cd\u4f5c\u7b80\u4fbf\u4f46\u7ec6\u80de\u5b58\u6d3b\u4e0e\u6574\u5408\u6548\u7387\u4f4e\uff1b\u7ec6\u80de\u7247\u5c42\u66f4\u6a21\u62df\u751f\u7406\u7ed3\u6784\u4f46\u624b\u672f\u590d\u6742\u3002\u672a\u6765\u9700\u7ed3\u5408\u751f\u7269\u6750\u6599\uff08\u5982PLGA\u652f\u67b6\u3001ORMOCER\u00ae\u819c\uff09\u4f18\u5316\u79fb\u690d\u6548\u679c\u3002<\/span><\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u60a3\u8005\u9009\u62e9\u4e0e\u7597\u6548\u8bc4\u4f30<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff1a\u65e9\u671f\u5e72\u9884\u53ef\u80fd\u5728\u75be\u75c5\u65e9\u671f\u9636\u6bb5\u53d6\u5f97\u66f4\u597d\u7597\u6548\u3002\u4f8b\u5982\uff0cCell Cure Neurosciences\u7684OpRegen\u5728\u8f7b\u5ea6AMD\u60a3\u8005\u4e2d\u663e\u793a\u89c6\u529b\u7ef4\u6301\u6216\u6539\u5584\uff08-2\u81f3+24\u4e2a\u5b57\u6bcd\uff09\uff0c\u800c\u91cd\u5ea6\u60a3\u8005\u6548\u679c\u6709\u9650\u3002<\/span><\/span><\/p>\n<h2><span class=\"ez-toc-section\" id=\"%E6%80%BB%E7%BB%93%E4%B8%8E%E5%B1%95%E6%9C%9B\"><\/span><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">Summary and outlook<\/span><\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p class=\"ds-markdown-paragraph\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">hPSC\u6765\u6e90\u7684RPE\u6cbb\u7597\u5728\u9ec4\u6591\u53d8\u6027\u7684\u4e34\u5e8a\u5e94\u7528\u4e2d\u5c55\u73b0\u51fa<\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u826f\u597d\u7684\u5b89\u5168\u6027\u4e0e\u521d\u6b65\u7597\u6548<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff0c\u591a\u9879\u65e9\u671f\u4e34\u5e8a\u8bd5\u9a8c\u8868\u660e\u79fb\u690d\u7ec6\u80de\u53ef\u957f\u671f\u5b58\u6d3b\u5e76\u53ef\u80fd\u7a33\u5b9a\u751a\u81f3\u6539\u5584\u89c6\u529b\u3002\u968f\u7740\u7ec6\u80de\u5236\u5907\u6280\u672f\u3001\u652f\u67b6\u6750\u6599\u53ca\u624b\u672f\u65b9\u5f0f\u7684\u4e0d\u65ad\u4f18\u5316\uff0c\u4ee5\u53ca\u9488\u5bf9\u66f4\u65e9\u671f\u60a3\u8005\u7684\u7814\u7a76\u5f00\u5c55\uff0chPSC\u7597\u6cd5\u6709\u671b\u4e3a\u5e72\u6027AMD\u3001Stargardt\u75c5\u3001\u6e7f\u6027AMD\u53ca\u5176\u4ed6\u89c6\u7f51\u819c\u9000\u884c\u6027\u75be\u75c5\u63d0\u4f9b\u7a81\u7834\u6027\u6cbb\u7597\u624b\u6bb5\u3002<\/span><\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u672a\u6765\u7684\u6838\u5fc3\u5728\u4e8e\u901a\u8fc7\u89c4\u6a21\u5316\u3001\u81ea\u52a8\u5316\u7684\u7ec6\u80de\u751f\u4ea7\u4f53\u7cfb\uff08\u5982\u5f17\u52b3\u6069\u970d\u592b\u534f\u4f1a\u5f00\u53d1\u7684\u7cfb\u7edf\uff09\u53ca\u7cbe\u51c6\u7684\u4e2a\u4f53\u5316\u6cbb\u7597\u65b9\u6848\uff0c\u63a8\u52a8\u8fd9\u4e00\u518d\u751f\u533b\u5b66\u7b56\u7565\u5411\u4e34\u5e8a\u5e38\u89c4\u5e94\u7528\u7684\u8f6c\u5316\u3002<\/span><\/span><\/p>","protected":false},"excerpt":{"rendered":"<p>\u89c6\u7f51\u819c\u8272\u7d20\u4e0a\u76ae\uff08RPE\uff09\u7ec6\u80de\u7684\u529f\u80fd\u969c\u788d\u6216\u4e27\u5931\u662f\u591a\u79cd\u9ec4\u6591\u53d8\u6027\u75be\u75c5\uff08\u5982\u5e74\u9f84\u76f8\u5173\u6027\u9ec4\u6591\u53d8\u6027\u3001Stargardt\u75c5\u7b49\uff09 [&hellip;]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[75],"tags":[193,221],"_links":{"self":[{"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/posts\/20419"}],"collection":[{"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/comments?post=20419"}],"version-history":[{"count":4,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/posts\/20419\/revisions"}],"predecessor-version":[{"id":20427,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/posts\/20419\/revisions\/20427"}],"wp:attachment":[{"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/media?parent=20419"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/categories?post=20419"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/tags?post=20419"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}