{"id":20428,"date":"2025-11-12T18:56:30","date_gmt":"2025-11-12T10:56:30","guid":{"rendered":"https:\/\/www.hjtdsm.cn\/?p=20428"},"modified":"2025-11-12T18:56:30","modified_gmt":"2025-11-12T10:56:30","slug":"%e5%a4%9a%e8%83%bd%e5%b9%b2%e7%bb%86%e8%83%9e%e6%b2%bb%e7%96%97%e4%b8%ad%e6%9e%a2%e7%a5%9e%e7%bb%8f%e7%b3%bb%e7%bb%9f%e7%96%be%e7%97%85","status":"publish","type":"post","link":"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/psc\/20428.html","title":{"rendered":"\u591a\u80fd\u5e72\u7ec6\u80de\u6cbb\u7597\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u7684\uff083\u5927\uff09\u4e34\u5e8a\u7814\u7a76\u8fdb\u5c55"},"content":{"rendered":"<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\uff08CNS\uff09\u75be\u75c5\uff0c\u5982\u5e15\u91d1\u68ee\u75c5\u3001\u810a\u9ad3\u635f\u4f24\u4e0e\u766b\u75eb\uff0c\u56e0\u5176\u795e\u7ecf\u7ec6\u80de\u635f\u4f24\u6216\u6b7b\u4ea1\u540e\u81ea\u6211\u4fee\u590d\u80fd\u529b\u6781\u4f4e\uff0c\u4e00\u76f4\u662f\u533b\u5b66\u9886\u57df\u7684\u91cd\u5927\u6cbb\u7597\u6311\u6218\u3002\u8fd1\u5e74\u6765\uff0c<\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u591a\u80fd\u5e72\u7ec6\u80de\u6cbb\u7597\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7684\u7814\u7a76\u53d6\u5f97\u4e86\u4ee4\u4eba\u77a9\u76ee\u7684\u8fdb\u5c55\uff0c\u4e3a\u8fd9\u4e9b\u65e2\u5f80\u88ab\u8ba4\u4e3a\u4e0d\u53ef\u9006\u7684\u635f\u4f24\u63d0\u4f9b\u4e86\u6f5c\u5728\u7684\u4fee\u590d\u7b56\u7565\u3002\u4eba\u591a\u80fd\u5e72\u7ec6\u80de\uff08hPSCs\uff09\uff0c\u5305\u62ec\u4eba\u80da\u80ce\u5e72\u7ec6\u80de\uff08hESCs\uff09\u548c\u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de\uff08iPSCs\uff09\uff0c\u5177\u6709\u65e0\u9650\u81ea\u6211\u66f4\u65b0\u548c\u5206\u5316\u4e3a\u4efb\u4f55\u7ec6\u80de\u7c7b\u578b\u7684\u6f5c\u80fd\uff0c\u4f7f\u5176\u6210\u4e3a\u518d\u751f\u533b\u5b66\u9886\u57df\u7406\u60f3\u7684\u7ec6\u80de\u6765\u6e90\u3002<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u672c\u6587\u65e8\u5728\u7cfb\u7edf\u7efc\u8ff0<\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u591a\u80fd\u5e72\u7ec6\u80de\u6cbb\u7597\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5728\u5e15\u91d1\u68ee\u75c5\u3001\u810a\u9ad3\u635f\u4f24\u4e0e\u766b\u75eb\u4e09\u5927\u9002\u5e94\u75c7\u4e2d\u7684\u6700\u65b0\u4e34\u5e8a\u7814\u7a76\u8fdb\u5c55\uff0c\u5e76\u63a2\u8ba8\u5176\u4f5c\u7528\u673a\u5236\u3001\u9762\u4e34\u7684\u6311\u6218\u53ca\u672a\u6765\u53d1\u5c55\u65b9\u5411\u3002<\/span><\/span><\/p>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_79_2 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewbox=\"0 0 24 24\" version=\"1.2\" baseprofile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/psc\/20428.html\/#1_%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E5%B8%95%E9%87%91%E6%A3%AE%E7%97%85%EF%BC%9A%E4%BB%8E%E6%9B%BF%E4%BB%A3%E5%88%B0%E7%B2%BE%E5%87%86\" >1 \u5e72\u7ec6\u80de\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\uff1a\u4ece\u66ff\u4ee3\u5230\u7cbe\u51c6<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/psc\/20428.html\/#11_%E5%A4%9A%E8%83%BD%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E4%B8%AD%E6%9E%A2%E7%A5%9E%E7%BB%8F%E7%B3%BB%E7%BB%9F%E7%96%BE%E7%97%85%E7%9A%84%E7%AD%96%E7%95%A5%E4%B8%8E%E6%BC%94%E5%8F%98\" >1.1 \u591a\u80fd\u5e72\u7ec6\u80de\u6cbb\u7597\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u7684\u7b56\u7565\u4e0e\u6f14\u53d8<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/psc\/20428.html\/#12_%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E5%B8%95%E9%87%91%E6%A3%AE%E7%97%85%E7%9A%84%E6%97%A9%E6%9C%9F%E4%B8%B4%E5%BA%8A%E8%AF%95%E9%AA%8C\" >1.2 \u5e72\u7ec6\u80de\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\u7684\u65e9\u671f\u4e34\u5e8a\u8bd5\u9a8c<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/psc\/20428.html\/#12_%E8%BF%91%E5%B9%B4%E6%9D%A5%E5%A4%9A%E8%83%BD%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E5%B8%95%E9%87%91%E6%A3%AE%E7%97%85%E7%9A%84%E5%85%A8%E7%90%83%E4%B8%B4%E5%BA%8A%E7%A0%94%E7%A9%B6%E8%BF%9B%E5%B1%95\" >1.2 \u8fd1\u5e74\u6765\u591a\u80fd\u5e72\u7ec6\u80de\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\u7684\u5168\u7403\u4e34\u5e8a\u7814\u7a76\u8fdb\u5c55<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/psc\/20428.html\/#2_%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E8%84%8A%E9%AB%93%E6%8D%9F%E4%BC%A4%EF%BC%9A%E5%86%8D%E7%94%9F%E4%BF%AE%E5%A4%8D%E7%9A%84%E6%96%B0%E5%B8%8C%E6%9C%9B\" >2 \u5e72\u7ec6\u80de\u6cbb\u7597\u810a\u9ad3\u635f\u4f24\uff1a\u518d\u751f\u4fee\u590d\u7684\u65b0\u5e0c\u671b<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/psc\/20428.html\/#21_%E7%97%85%E7%90%86%E6%8C%91%E6%88%98%E4%B8%8E%E6%B2%BB%E7%96%97%E7%AD%96%E7%95%A5\" >2.1 \u75c5\u7406\u6311\u6218\u4e0e\u6cbb\u7597\u7b56\u7565<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/psc\/20428.html\/#22_%E5%A4%9A%E8%83%BD%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E8%84%8A%E9%AB%93%E6%8D%9F%E4%BC%A4%E7%9A%84%E4%B8%B4%E5%BA%8A%E8%BD%AC%E5%8C%96%E4%B8%8E%E8%BF%9B%E5%B1%95\" >2.2 \u591a\u80fd\u5e72\u7ec6\u80de\u6cbb\u7597\u810a\u9ad3\u635f\u4f24\u7684\u4e34\u5e8a\u8f6c\u5316\u4e0e\u8fdb\u5c55<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/psc\/20428.html\/#3_%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E7%99%AB%E7%97%AB%EF%BC%9A%E8%B0%83%E6%8E%A7%E7%A5%9E%E7%BB%8F%E7%8E%AF%E8%B7%AF%E7%9A%84%E6%96%B0%E7%AD%96%E7%95%A5\" >3 \u5e72\u7ec6\u80de\u6cbb\u7597\u766b\u75eb\uff1a\u8c03\u63a7\u795e\u7ecf\u73af\u8def\u7684\u65b0\u7b56\u7565<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/psc\/20428.html\/#31_%E7%97%85%E7%90%86%E5%9F%BA%E7%A1%80%E4%B8%8E%E6%B2%BB%E7%96%97%E6%96%B0%E6%80%9D%E8%B7%AF\" >3.1 \u75c5\u7406\u57fa\u7840\u4e0e\u6cbb\u7597\u65b0\u601d\u8def<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/psc\/20428.html\/#32_%E4%B8%B4%E5%BA%8A%E5%89%8D%E7%A0%94%E7%A9%B6%E4%B8%8E%E4%B8%B4%E5%BA%8A%E6%8E%A2%E7%B4%A2\" >3.2 \u4e34\u5e8a\u524d\u7814\u7a76\u4e0e\u4e34\u5e8a\u63a2\u7d22<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/psc\/20428.html\/#4%E5%A4%9A%E8%83%BD%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E5%85%B6%E5%AE%83%E4%B8%AD%E6%9E%A2%E7%A5%9E%E7%BB%8F%E7%B3%BB%E7%BB%9F%E7%96%BE%E7%97%85%E7%9A%84%E4%B8%B4%E5%BA%8A%E7%A0%94%E7%A9%B6%E8%BF%9B%E5%B1%95\" >4.\u591a\u80fd\u5e72\u7ec6\u80de\u6cbb\u7597\u5176\u5b83\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u7684\u4e34\u5e8a\u7814\u7a76\u8fdb\u5c55<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/psc\/20428.html\/#5_%E6%8C%91%E6%88%98%E4%B8%8E%E6%9C%AA%E6%9D%A5%E6%96%B9%E5%90%91\" >5. \u6311\u6218\u4e0e\u672a\u6765\u65b9\u5411<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/psc\/20428.html\/#51_%E7%A7%91%E5%AD%A6%E6%8C%91%E6%88%98\" >5.1 \u79d1\u5b66\u6311\u6218<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/psc\/20428.html\/#52_%E6%8A%80%E6%9C%AF%E4%B8%8E%E7%9B%91%E7%AE%A1%E7%93%B6%E9%A2%88\" >5.2 \u6280\u672f\u4e0e\u76d1\u7ba1\u74f6\u9888<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/psc\/20428.html\/#53_%E6%9C%AA%E6%9D%A5%E5%B1%95%E6%9C%9B\" >5.3 \u672a\u6765\u5c55\u671b<\/a><\/li><\/ul><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"1_%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E5%B8%95%E9%87%91%E6%A3%AE%E7%97%85%EF%BC%9A%E4%BB%8E%E6%9B%BF%E4%BB%A3%E5%88%B0%E7%B2%BE%E5%87%86\"><\/span><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">1 \u5e72\u7ec6\u80de\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\uff1a\u4ece\u66ff\u4ee3\u5230\u7cbe\u51c6<\/span><\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p class=\"ds-markdown-paragraph\"><a href=\"https:\/\/www.hjtdsm.cn\/en\/research\/ns\/pd\/19756.html\/\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5e15\u91d1\u68ee\u75c5\uff08Parkinson&#8217;s Disease, PD\uff09<\/span><\/span><\/a><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4f5c\u4e3a\u4e00\u79cd<\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5e38\u89c1\u7684\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff0c\u5176\u6838\u5fc3\u75c5\u7406\u7279\u5f81\u662f\u4e2d\u8111\u9ed1\u8d28\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u7684<\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u9009\u62e9\u6027\u4e27\u5931<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff0c\u5bfc\u81f4\u7eb9\u72b6\u4f53\u591a\u5df4\u80fa\u4e0d\u8db3\u800c\u5f15\u8d77\u8fd0\u52a8\u75c7\u72b6\u3002\u5168\u7403PD\u60a3\u8005\u4eba\u6570\u4f17\u591a\uff0c\u4e14\u968f\u7740\u4eba\u53e3\u8001\u9f84\u5316\u52a0\u5267\uff0c\u5176\u53d1\u75c5\u7387\u5448\u4e0a\u5347\u8d8b\u52bf\u3002\u5f53\u524d\u7684\u6cbb\u7597\u65b9\u6cd5\u4e3b\u8981\u4ee5\u5de6\u65cb\u591a\u5df4\u4e3a\u4ee3\u8868\u7684\u836f\u7269\u7f13\u89e3\u75c7\u72b6\uff0c\u4f46\u957f\u671f\u4f7f\u7528\u4f1a\u5bfc\u81f4\u7597\u6548\u51cf\u9000\u548c\u8fd0\u52a8\u5e76\u53d1\u75c7\u7b49\u5c40\u9650\u6027\u3002\u56e0\u6b64\uff0c\u5e72\u7ec6\u80de\u66ff\u4ee3\u6cbb\u7597\u4f5c\u4e3a\u4e00\u79cd<\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6f5c\u5728\u75be\u75c5\u4fee\u9970\u7b56\u7565<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff0c\u65e8\u5728\u91cd\u5efa\u53d7\u635f\u7684\u795e\u7ecf\u73af\u8def\uff0c\u4e3aPD\u60a3\u8005\u5e26\u6765\u65b0\u7684\u5e0c\u671b\u3002<\/span><\/span><\/p>\n<h3><span class=\"ez-toc-section\" id=\"11_%E5%A4%9A%E8%83%BD%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E4%B8%AD%E6%9E%A2%E7%A5%9E%E7%BB%8F%E7%B3%BB%E7%BB%9F%E7%96%BE%E7%97%85%E7%9A%84%E7%AD%96%E7%95%A5%E4%B8%8E%E6%BC%94%E5%8F%98\"><\/span><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">1.1 \u591a\u80fd\u5e72\u7ec6\u80de\u6cbb\u7597\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u7684\u7b56\u7565\u4e0e\u6f14\u53d8<\/span><\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p class=\"ds-markdown-paragraph\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u81ea20\u4e16\u7eaa80\u5e74\u4ee3\u672b\u4ee5\u6765\uff0c\u7814\u7a76\u4eba\u5458\u5c31\u5f00\u59cb\u5c1d\u8bd5\u901a\u8fc7\u8111\u5185\u79fb\u690d\u4eba\u7c7b\u80ce\u513f\u4e2d\u8111\u7ec4\u7ec7\u6765\u66ff\u4ee3PD\u60a3\u8005\u8111\u4e2d\u4e22\u5931\u7684\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u3002\u8fd9\u4e9b\u5f00\u521b\u6027\u7814\u7a76\u8bc1\u5b9e\u4e86\u7ec6\u80de\u66ff\u4ee3\u6cbb\u7597PD\u7684<\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6982\u5ff5\u53ef\u884c\u6027<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u2014\u2014\u79fb\u690d\u7684\u80ce\u513f\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u80fd\u591f\u5728\u60a3\u8005\u8111\u5185\u5b58\u6d3b\u3001\u6574\u5408\u5e76\u6539\u5584\u8fd0\u52a8\u529f\u80fd\u3002\u7136\u800c\uff0c\u80ce\u513f\u7ec4\u7ec7\u79fb\u690d\u5b58\u5728<\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6765\u6e90\u6709\u9650\u3001\u5f02\u8d28\u6027\u5f3a\u53ca\u4f26\u7406\u4e89\u8bae<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7b49\u7a81\u51fa\u95ee\u9898\uff0c\u9650\u5236\u4e86\u5176\u4e34\u5e8a\u63a8\u5e7f\u5e94\u7528\u3002<\/span><\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><a href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/psc\/19806.html\/\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4eba\u591a\u80fd\u5e72\u7ec6\u80de<\/span><\/span><\/a><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff08human pluripotent stem cells, hPSCs\uff09\u6280\u672f\uff0c\u5305\u62ec\u4eba\u80da\u80ce\u5e72\u7ec6\u80de\uff08human embryonic stem cells, hESCs\uff09\u548c\u4eba\u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de\uff08human induced pluripotent stem cells, hiPSCs\uff09\u7684\u53d1\u5c55\uff0c\u4e3aPD\u7684\u7ec6\u80de\u6cbb\u7597\u63d0\u4f9b\u4e86<\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6807\u51c6\u5316\u3001\u89c4\u6a21\u5316\u7684\u7ec6\u80de\u6765\u6e90<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u3002\u8fc7\u53bb\u5341\u5e74\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u5df2\u5efa\u7acb\u4e86\u591a\u79cd\u5c06hPSCs\u9ad8\u6548\u5206\u5316\u4e3a\u4e2d\u8111\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u524d\u4f53\u7ec6\u80de\uff08dopaminergic progenitor cells, DAPs\uff09\u7684\u65b9\u6848\uff0c\u8fd9\u4e9b\u7ec6\u80de\u5728\u79fb\u690d\u5230PD\u52a8\u7269\u6a21\u578b\u8111\u540e\u80fd\u591f\u6210\u719f\u4e3a\u529f\u80fd\u6027\u7684\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\uff0c\u6574\u5408\u5230\u5bbf\u4e3b\u795e\u7ecf\u73af\u8def\u4e2d\uff0c\u5e76\u663e\u7740\u6539\u5584\u52a8\u7269\u7684\u8fd0\u52a8\u884c\u4e3a\u7f3a\u9677\u3002<\/span><\/span><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-20436 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/istockphoto-610586196-612x612-1.jpg\" alt=\"\u591a\u80fd\u5e72\u7ec6\u80de\u6cbb\u7597\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u7684\u4e34\u5e8a\u7814\u7a76\u8fdb\u5c55\uff1a\u5e15\u91d1\u68ee\u75c5\u3001\u810a\u9ad3\u635f\u4f24\u4e0e\u766b\u75eb\" width=\"612\" height=\"398\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/istockphoto-610586196-612x612-1.jpg 612w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/istockphoto-610586196-612x612-1-300x195.jpg 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/istockphoto-610586196-612x612-1-18x12.jpg 18w\" sizes=\"(max-width: 612px) 100vw, 612px\" \/><\/p>\n<h3><span class=\"ez-toc-section\" id=\"12_%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E5%B8%95%E9%87%91%E6%A3%AE%E7%97%85%E7%9A%84%E6%97%A9%E6%9C%9F%E4%B8%B4%E5%BA%8A%E8%AF%95%E9%AA%8C\"><\/span><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">1.2 \u5e72\u7ec6\u80de\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\u7684\u65e9\u671f\u4e34\u5e8a\u8bd5\u9a8c<\/span><\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p data-start=\"344\" data-end=\"593\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u9996\u4e2a\u9488\u5bf9PD\u7684<\/span><\/span><strong data-start=\"351\" data-end=\"371\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4eba\u80da\u80ce\u5e72\u7ec6\u80de\uff08hESC\uff09\u4e34\u5e8a\u8bd5\u9a8c<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e8e2015\u5e74\u5728\u4e2d\u56fd\u542f\u52a8\uff08NCT03119636\uff09\uff0c\u5171\u4e3a24\u540d\u60a3\u8005\u79fb\u690d\u4e86DA\u524d\u4f53\u7ec6\u80de\uff0c\u4f46\u5c1a\u672a\u516c\u5e03\u4e34\u5e8a\u7ed3\u679c\u3002\u968f\u540e\uff0c<\/span><\/span><a href=\"https:\/\/www.accesswire.com\/653700\/International-Stem-Cell-Corporation-Announces-Successful-Completion-of-Its-Phase-1-Clinical-Trial-in-Parkinsons-Disease\" target=\"_blank\" rel=\"noopener nofollow\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6fb3\u5927\u5229\u4e9a\u7684\u56fd\u9645\u5e72\u7ec6\u80de\u516c\u53f8\uff08ISCO\uff09<\/span><\/span><strong data-start=\"446\" data-end=\"460\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e8e2016\u5e74\u5f00\u5c55\u4e86\u4ee5<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5b64\u96cc\u751f\u6b96\u5e72\u7ec6\u80de\uff08hpESCs\uff09\u4e3a\u57fa\u7840\u7684\u8bd5\u9a8c<\/span><\/span><\/a><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff0c\u5e76\u4e8e2021\u5e74\u8fbe\u5230\u4e3b\u8981\u5b89\u5168\u6027\u7ec8\u70b9\uff0c\u4f46\u516c\u53f8\u5e76\u672a\u516c\u5e03\u540e\u7eed\u4e34\u5e8a\u8ba1\u5212\u3002\u8be5\u8bd5\u9a8c\u56e0\u4f7f\u7528\u4e86\u4e00\u79cd\u201c\u901a\u7528\u578b\u795e\u7ecf\u5e72\u7ec6\u80de\uff08NSC\uff09\u201d\u4ea7\u54c1\u800c\u53d7\u5230\u8d28\u7591\u2014\u2014\u5176\u4f5c\u7528\u673a\u7406\u88ab\u8ba4\u4e3a\u662f\u901a\u8fc7\u8425\u517b\u56e0\u5b50\u652f\u6301\u4fdd\u62a4\u5185\u6e90DA\u795e\u7ecf\u5143\u514d\u4e8e\u51cb\u4ea1\uff0c\u800c\u975e\u771f\u6b63\u6062\u590d\u591a\u5df4\u80fa\u529f\u80fd\u3002<\/span><\/span><\/p>\n<div id=\"attachment_20430\" style=\"width: 1625px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-20430\" class=\"wp-image-20430 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-12_180044_356.png\" alt=\"\" width=\"1615\" height=\"296\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-12_180044_356.png 1615w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-12_180044_356-300x55.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-12_180044_356-1024x188.png 1024w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-12_180044_356-768x141.png 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-12_180044_356-1536x282.png 1536w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-12_180044_356-18x3.png 18w\" sizes=\"(max-width: 1615px) 100vw, 1615px\" \/><p id=\"caption-attachment-20430\" class=\"wp-caption-text\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u56fd\u9645\u5e72\u7ec6\u80de\u516c\u53f8\u5ba3\u5e03\u5176\u5e15\u91d1\u68ee\u75c5\u4e00\u671f\u4e34\u5e8a\u8bd5\u9a8c\u6210\u529f\u5b8c\u6210<\/span><\/span><\/p><\/div>\n<p data-start=\"595\" data-end=\"891\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7814\u7a76\u65b9\u5411\u968f\u540e\u8f6c\u5411<\/span><\/span><strong data-start=\"603\" data-end=\"619\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u66f4\u9ad8\u5206\u8fa8\u7387\u3001\u66f4\u7cbe\u51c6\u7684\u4ea7\u54c1<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff0c\u5373\u57fa\u4e8e<\/span><\/span><strong data-start=\"623\" data-end=\"650\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4eba\u591a\u80fd\u5e72\u7ec6\u80de\uff08hPSC\uff09\u5206\u5316\u7684\u4e2d\u8111DA\u524d\u4f53\u7ec6\u80de<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">The<\/span><\/span><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2352320420300614?via%3Dihub\" target=\"_blank\" rel=\"noopener nofollow\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u65e5\u672c\u4eac\u90fd\u5927\u5b66iPS\u7ec6\u80de\u7814\u7a76\u4e2d\u5fc3\uff08CiRA\uff09\u7684<\/span><\/span><\/a><strong data-start=\"673\" data-end=\"757\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u9ad8\u6865\u6df3\uff08Jun Takahashi\uff09\u56e2\u961f\u5f00\u53d1\u4e86\u9996\u4e2a\u8fdb\u5165PD\u4e34\u5e8a\u8bd5\u9a8c\u7684\u4eba\u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de\uff08hiPSC\uff09\u4ea7\u54c1\u3002\u8be5\u4ea7\u54c1\u6765\u81ea\u5177\u6709HLA\u5355\u500d\u578b\u7684\u540c\u79cd\u5f02\u4f53hiPSC\u7cfb<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff0c\u5e76\u7ecf<\/span><\/span><strong data-start=\"760\" data-end=\"769\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">CORIN<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8868\u9762\u6807\u5fd7\u7eaf\u5316\uff0c\u4ee3\u8868\u4e2d\u8111\u5e95\u677f\u524d\u4f53\u7ec6\u80de\u8c31\u7cfb\u3002\u8bd5\u9a8c\u4e8e2018\u5e74\u542f\u52a8\uff0c\u51717\u4f8b\u60a3\u8005\uff0c\u7ed3\u679c\u663e\u793a\u826f\u597d\u7684\u5b89\u5168\u6027\uff0c\u5e76\u5728\u90e8\u5206\u60a3\u8005\u4e2d\u89c2\u5bdf\u5230\u4e2d\u5ea6\u6539\u5584\uff08\u9ad8\u6865\u6df3\u4e2a\u4eba\u901a\u4fe1\uff09\u3002\u8be5\u4ea7\u54c1\u73b0\u7531\u65e5\u672c\u4f4f\u53cb\u5236\u836f\uff08Sumitomo Pharma\uff09\u4e0e\u5b66\u672f\u673a\u6784\u5408\u4f5c\uff0c\u5728\u7f8e\u56fd\u7ee7\u7eed\u63a8\u8fdb\u4e34\u5e8a\u7814\u7a76\u3002<\/span><\/span><\/p>\n<div id=\"attachment_20429\" style=\"width: 688px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-20429\" class=\"wp-image-20429 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-12_180223_141.png\" alt=\"\" width=\"678\" height=\"448\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-12_180223_141.png 678w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-12_180223_141-300x198.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-12_180223_141-18x12.png 18w\" sizes=\"(max-width: 678px) 100vw, 678px\" \/><p id=\"caption-attachment-20429\" class=\"wp-caption-text\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u57fa\u4e8e\u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de\u7684\u5e15\u91d1\u68ee\u75c5\u7597\u6cd5\uff1a\u4eac\u90fd\u8bd5\u9a8c<\/span><\/span><\/p><\/div>\n<h3><span class=\"ez-toc-section\" id=\"12_%E8%BF%91%E5%B9%B4%E6%9D%A5%E5%A4%9A%E8%83%BD%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E5%B8%95%E9%87%91%E6%A3%AE%E7%97%85%E7%9A%84%E5%85%A8%E7%90%83%E4%B8%B4%E5%BA%8A%E7%A0%94%E7%A9%B6%E8%BF%9B%E5%B1%95\"><\/span><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">1.2 \u8fd1\u5e74\u6765\u591a\u80fd\u5e72\u7ec6\u80de\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\u7684\u5168\u7403\u4e34\u5e8a\u7814\u7a76\u8fdb\u5c55<\/span><\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p class=\"ds-markdown-paragraph\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8fd1\u5e74\u6765\uff0c\u57fa\u4e8ehPSCs\u7684PD\u7ec6\u80de\u6cbb\u7597\u5df2\u4ece\u4e34\u5e8a\u524d\u7814\u7a76\u9010\u6b65\u8d70\u5411\u4e34\u5e8a\u8bc4\u4f30\u3002 2025\u5e74\u53d1\u8868\u5728\u300a\u81ea\u7136\u300b\u6742\u5fd7\u4e0a\u7684\u4e24\u9879\u72ec\u7acb\u4e34\u5e8a\u8bd5\u9a8c\u4e3a\u8fd9\u4e00\u9886\u57df\u63d0\u4f9b\u4e86<\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4ee4\u4eba\u9f13\u821e\u7684\u5b89\u5168\u6027\u548c\u521d\u6b65\u6709\u6548\u6027\u6570\u636e<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">The<\/span><\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><a href=\"https:\/\/www.nature.com\/articles\/s41586-025-08700-0\" target=\"_blank\" rel=\"noopener nofollow\">\u65e5\u672c\u4eac\u90fd\u5927\u5b66\u56e2\u961f\u5f00\u5c55\u4e86\u4e00\u9879I\/II\u671f\u4e34\u5e8a\u8bd5\u9a8c<\/a>\uff0c\u4e3a7\u540d50-69\u5c81\u7684PD\u60a3\u8005\u79fb\u690d\u4e86\u7531hiPSCs\u5206\u5316\u800c\u6765\u7684\u591a\u5df4\u80fa\u80fd\u524d\u4f53\u7ec6\u80de\u3002\u5728<strong>24\u4e2a\u6708\u7684\u968f\u8bbf\u671f\u5185<\/strong>\uff0c\u672a\u62a5\u544a\u4e25\u91cd\u526f\u4f5c\u7528\uff0c\u79fb\u690d\u7684\u7ec6\u80de\u4ea7\u751f\u4e86\u591a\u5df4\u80fa\uff0c\u4e14\u6ca1\u6709\u8fc7\u5ea6\u751f\u957f\u6216\u5f62\u6210\u80bf\u7624\u2014\u2014\u8fd9\u662f\u5e72\u7ec6\u80de\u7597\u6cd5\u7684\u4e00\u79cd\u6f5c\u5728\u98ce\u9669\u3002\u7279\u522b\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u5728\u7ee7\u7eed\u53c2\u4e0e\u8bd5\u9a8c\u5e76\u8fdb\u884c\u6709\u6548\u6027\u8bc4\u4f30\u76846\u4f4d\u60a3\u8005\u4e2d\uff0c4\u4f4d\u5728\u672a\u670d\u7528\u6807\u51c6\u836f\u7269\u7684\u60c5\u51b5\u4e0b\u5e15\u91d1\u68ee\u75c5\u76f8\u5173\u8fd0\u52a8\u75c7\u72b6\u51cf\u5c11\uff0c5\u4f4d\u5728\u670d\u836f\u671f\u95f4\u89c2\u5bdf\u5230\u76f8\u5173\u8fd0\u52a8\u75c7\u72b6\u51cf\u5c11\u3002<\/p>\n<div id=\"attachment_20432\" style=\"width: 767px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-20432\" class=\"wp-image-20432 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/wechat_2025-10-17_123621_053.png\" alt=\"\" width=\"757\" height=\"508\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/wechat_2025-10-17_123621_053.png 757w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/wechat_2025-10-17_123621_053-300x201.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/wechat_2025-10-17_123621_053-18x12.png 18w\" sizes=\"(max-width: 757px) 100vw, 757px\" \/><p id=\"caption-attachment-20432\" class=\"wp-caption-text\">\u5e15\u91d1\u68ee\u75c5iPS\u7ec6\u80de\u884d\u751f\u591a\u5df4\u80fa\u80fd\u7ec6\u80de\u7684I\/II\u671f\u4e34\u5e8a\u8bd5\u9a8c<\/p><\/div>\n<p class=\"ds-markdown-paragraph\"><a href=\"https:\/\/www.nature.com\/articles\/s41586-025-08845-y\" target=\"_blank\" rel=\"noopener nofollow\">\u53e6\u4e00\u9879\u7531\u7f8e\u56fd\u7eaa\u5ff5\u65af\u9686-\u51ef\u7279\u7433\u764c\u75c7\u4e2d\u5fc3\u56e2\u961f\u57282025\u5e74\u8fdb\u884c\u7684I\u671f\u4e34\u5e8a\u8bd5\u9a8c<\/a>\uff0c\u8bc4\u4f30\u4e86\u6765\u81ea\u4eba\u80da\u80ce\u5e72\u7ec6\u80de\u7684\u591a\u5df4\u80fa\u80fd\u524d\u4f53\u7ec6\u80de\u4ea7\u54c1\uff08bemdaneprocel\uff09\u7684\u5b89\u5168\u6027\u300212\u540d\u4e2d\u4f4d\u5e74\u9f84\u4e3a67\u5c81\u7684\u60a3\u8005\u63a5\u53d7\u4e86\u5c06\u8be5\u4ea7\u54c1\u79fb\u690d\u5230\u53cc\u4fa7\u5927\u8111\u58f3\u6838\u7684\u624b\u672f\u3002\u7ed3\u679c\u663e\u793a\uff0c\u7ec6\u80de\u4ea7\u54c1<strong>\u8010\u53d7\u6027\u666e\u904d\u826f\u597d<\/strong>\uff0c\u572818\u4e2a\u6708\u7684\u968f\u8bbf\u4e2d\u672a\u62a5\u544a\u4e0e\u6cbb\u7597\u76f8\u5173\u7684\u4e25\u91cd\u526f\u4f5c\u7528\uff0c\u4e5f\u6ca1\u6709\u51fa\u73b0\u8fd0\u52a8\u969c\u788d\u7684\u8ff9\u8c61\u3002\u7814\u7a76\u56e2\u961f\u5728\u4f4e\u5242\u91cf\u548c\u9ad8\u5242\u91cf\u7ec4\u5747\u89c2\u5bdf\u5230\u4e86\u4e0d\u540c\u7a0b\u5ea6\u7684\u8fd0\u52a8\u529f\u80fd\u6539\u5584\u3002\u516c\u53f8\u5df2\u5ba3\u5e03\u5373\u5c06\u542f\u52a8\u2161\u671f\u7814\u7a76\u3002<\/p>\n<div id=\"attachment_20431\" style=\"width: 756px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-20431\" class=\"wp-image-20431 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/wechat_2025-10-17_123722_444.png\" alt=\"\" width=\"746\" height=\"443\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/wechat_2025-10-17_123722_444.png 746w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/wechat_2025-10-17_123722_444-300x178.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/wechat_2025-10-17_123722_444-18x12.png 18w\" sizes=\"(max-width: 746px) 100vw, 746px\" \/><p id=\"caption-attachment-20431\" class=\"wp-caption-text\">\u5229\u7528\u4eba\u80da\u80ce\u5e72\u7ec6\u80de\u884d\u751f\u7684\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\u7684I\u671f\u4e34\u5e8a\u8bd5\u9a8c<\/p><\/div>\n<p>\u540c\u6837\uff0c<a href=\"https:\/\/clinicaltrials.gov\/study\/NCT05887466\" target=\"_blank\" rel=\"noopener nofollow\">\u97e9\u56fd<strong data-start=\"1105\" data-end=\"1120\">S.Biomedics<\/strong>\u516c\u53f8\u4e8e2023\u5e74\u5f00\u5c55hESC\u8bd5\u9a8c\uff08NCT05887466\uff09<\/a>\uff0c\u57282024\u5e74\u516c\u5e03\u7ed3\u679c\u8868\u660e\u57283\u540d\u9ad8\u5242\u91cf\u60a3\u8005\u4e2d\u89c2\u5bdf\u523012\u4e2a\u6708\u65f6<strong data-start=\"1167\" data-end=\"1184\">PD\u75c7\u72b6\u4e0b\u964d25%\u201344%<\/strong>The<\/p>\n<div id=\"attachment_20434\" style=\"width: 964px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-20434\" class=\"wp-image-20434 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-12_181740_030.png\" alt=\"\" width=\"954\" height=\"582\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-12_181740_030.png 954w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-12_181740_030-300x183.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-12_181740_030-768x469.png 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-12_181740_030-18x12.png 18w\" sizes=\"(max-width: 954px) 100vw, 954px\" \/><p id=\"caption-attachment-20434\" class=\"wp-caption-text\">S.BIOMEDICS\u516c\u53f8\u7814\u53d1\u7684\u7528\u4e8e\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\u7684TED-A9\u7ec6\u80de\u7597\u6cd5\u57281\/2a\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d12\u4e2a\u6708\u65f6\u663e\u793a\u51fa\u79ef\u6781\u6570\u636e<\/p><\/div>\n<p>2022\u5e74\uff0c\u745e\u5178<strong data-start=\"1187\" data-end=\"1278\">\u9686\u5fb7\u5927\u5b66\u533b\u9662\uff08Sk\u00e5ne University Hospital\uff09\u7531Malin Parmar\u4e0eRoger Barker\u9886\u5bfc\u7684\u56e2\u961f\u4e5f\u57282022\u5e74\u542f\u52a8\u4e86\u540d\u4e3aSTEM-PD<\/strong>\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff08NCT05635409\uff09\u3002\u8fd9\u4e9b\u5728\u7f8e\u3001\u65e5\u3001\u745e\u3001\u97e9\u7684\u7814\u7a76\u5747\u91c7\u7528<strong data-start=\"1313\" data-end=\"1332\">16\u201328\u5929\u7684\u77ed\u7a0b\u5b9a\u5411\u5206\u5316\u4f53\u7cfb<\/strong>The<\/p>\n<div id=\"attachment_20433\" style=\"width: 1104px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-20433\" class=\"wp-image-20433 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-12_182048_748.png\" alt=\"\" width=\"1094\" height=\"374\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-12_182048_748.png 1094w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-12_182048_748-300x103.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-12_182048_748-1024x350.png 1024w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-12_182048_748-768x263.png 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-12_182048_748-18x6.png 18w\" sizes=\"(max-width: 1094px) 100vw, 1094px\" \/><p id=\"caption-attachment-20433\" class=\"wp-caption-text\">STEM-PD\u4e34\u5e8a\u8bd5\u9a8c\u6700\u65b0\u8fdb\u5c55\u2014\u2014\u57fa\u4e8e\u5e72\u7ec6\u80de\u7684\u5e15\u91d1\u68ee\u75c5\u79fb\u690d<\/p><\/div>\n<p>\u6b64\u5916\uff0c\u4e2d\u56fd\u7684<strong data-start=\"1339\" data-end=\"1403\">iRegene Therapeutics\uff08\u827e\u745e\u57fa\u56e0\uff09\u5f00\u53d1\u4e86\u5316\u5b66\u8bf1\u5bfc\u578b\u540c\u79cd\u5f02\u4f53hiPSC\u4ea7\u54c1 NouvNeu001<\/strong>\uff0c\u4e8e2024\u5e741\u6708\u5728\u4e2d\u56fd\u542f\u52a8\u4e34\u5e8a\uff0c\u5e76\u4e8e\u540c\u5e746\u6708\u83b7\u5f97FDA\u6279\u51c6\u5728\u7f8e\u56fd\u5f00\u5c55\u8bd5\u9a8c\u3002<\/p>\n<p>PD\u7814\u7a76\u7684\u6210\u529f\u4e5f\u63a8\u52a8\u4e86<strong data-start=\"1456\" data-end=\"1466\">\u81ea\u4f53\u7ec6\u80de\u6cbb\u7597<\/strong>\u7684\u53d1\u5c55\u3002<\/p>\n<p>2017\u5e74\uff0c\u7f8e\u56fd\u6ce2\u58eb\u987f\u9ea6\u514b\u83b1\u6069\u533b\u9662\uff08McLean Hospital\uff09\u7684\u4e00\u540d\u60a3\u8005\u6210\u4e3a\u5168\u7403\u7b2c\u4e8c\u4e2a\u63a5\u53d7<strong data-start=\"1518\" data-end=\"1531\">\u81ea\u4f53hiPSC\u79fb\u690d<\/strong>\u7684PD\u60a3\u8005\uff08\u5355\u4f8b\u6269\u5c55\u51c6\u5165\u7814\u7a76\uff0c\u9886\u5bfc\u8005Kwang-Soo Kim\u56e2\u961f\uff09\u3002\u672f\u540e12\u4e2a\u6708PET\u6210\u50cf\u663e\u793a\u79fb\u690d\u7269\u5b58\u6d3b\u8ff9\u8c61\u3002<\/p>\n<p>2023\u5e74\uff0c\u8be5\u56e2\u961f\u83b7\u5f97FDA\u6279\u51c6\uff0c\u5c06<strong data-start=\"1605\" data-end=\"1624\">\u81ea\u4f53DA\u7ec6\u80de\u79fb\u690d\u6269\u5927\u81f38\u540d\u60a3\u8005<\/strong>\uff08NCT06687837\uff09\u3002\u540c\u5e74\uff0cFDA\u53c8\u6279\u51c6\u4e86\u4e24\u9879\u57fa\u4e8e\u81ea\u4f53hiPSCs\u7684PD\u8bd5\u9a8c\uff1a\u4e00\u9879\u4e3a<strong data-start=\"1669\" data-end=\"1691\">Aspen Neuroscience<\/strong>\u516c\u53f8\u7684<strong data-start=\"1694\" data-end=\"1707\">ANPD001\u9879\u76ee<\/strong>\uff08\u9996\u4f8b\u60a3\u8005\u4e8e2024\u5e74\u6625\u5b63\u63a5\u53d7\u79fb\u690d\uff09\uff0c\u53e6\u4e00\u9879\u7531\u9ea6\u514b\u83b1\u6069\u533b\u9662<strong data-start=\"1736\" data-end=\"1756\">Penelope Hallett<\/strong>\u56e2\u961f\u5f00\u5c55\uff08NCT06422208\uff09\uff0c\u5df2\u5b8c\u6210\u4e24\u4f8b\u79fb\u690d\u3002<\/p>\n<p class=\"ds-markdown-paragraph\">\u8fd9\u4e9b\u7814\u7a76\u9996\u6b21\u5728\u8f83\u5927\u6837\u672c\u7684\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u8bc1\u5b9e\u4e86hPSC\u6765\u6e90\u7684\u591a\u5df4\u80fa\u80fd\u524d\u4f53\u7ec6\u80de\u5728PD\u60a3\u8005\u4e2d\u7684<strong>\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027<\/strong>\uff0c\u4e3a\u540e\u7eed\u66f4\u5927\u89c4\u6a21\u7684\u4e34\u5e8a\u8bd5\u9a8c\u5960\u5b9a\u4e86\u57fa\u7840\u3002\u4e0d\u8fc7\uff0c\u7814\u7a76\u4eba\u5458\u4e5f\u5f3a\u8c03\uff0c\u4ecd\u9700\u8fdb\u4e00\u6b65\u7814\u7a76\u6765\u6d4b\u8bd5\u8fd9\u4e9b\u7597\u6cd5\u7684\u6709\u6548\u6027\u548c\u4e34\u5e8a\u83b7\u76ca\u3002<\/p>\n<p class=\"ds-markdown-paragraph\">\u9664\u4e86\u4f20\u7edf\u7684\u7ec6\u80de\u66ff\u4ee3\u7b56\u7565\uff0c<strong>\u521b\u65b0\u6027\u7684\u7ed9\u836f\u65b9\u5f0f\u548c\u5236\u5242\u7b56\u7565<\/strong>\u4e5f\u5728\u4e0d\u65ad\u6d8c\u73b0\u3002\u4f8b\u5982\uff0c2025\u5e7410\u6708\u53d1\u8868\u7684\u4e00\u9879\u4e34\u5e8a\u524d\u7814\u7a76\u63a2\u7d22\u4e86\u901a\u8fc7\u9f3b\u5185\u9012\u9001\u7259\u9ad3\u5e72\u7ec6\u80de\u6765\u6e90\u7684\u5c0f\u7ec6\u80de\u5916\u56ca\u6ce1\uff08sEV\uff09\u5305\u88f9\u6839\u76ae\u82f7\uff08sEV-Phl\uff09\u6cbb\u7597PD\u7684\u65b0\u7b56\u7565\u3002\u8fd9\u79cd\u7b56\u7565\u5728\u6162\u6027MPTP PD\u5927\u9f20\u6a21\u578b\u4e2d\u663e\u793a\u51fa\u80fd\u591f<strong>\u663e\u8457\u6539\u5584\u8fd0\u52a8\u548c\u8ba4\u77e5\u529f\u80fd<\/strong>\uff0c\u589e\u52a0\u9ed1\u8d28\u4e2d\u916a\u6c28\u9178\u7f9f\u5316\u9176\uff08TH\uff09\u9633\u6027\u795e\u7ecf\u5143\u6570\u91cf\uff0c\u5e76\u51cf\u5c11\u795e\u7ecf\u708e\u75c7\u3002\u8fd9\u79cd<strong>\u65e0\u521b\u3001\u9776\u5411\u7684\u7ed9\u836f\u65b9\u5f0f<\/strong>\u4e3aPD\u6cbb\u7597\u63d0\u4f9b\u4e86\u65b0\u7684\u601d\u8def\u3002<\/p>\n<p>\u76ee\u524d\uff0c\u5168\u7403<strong data-start=\"1790\" data-end=\"1809\">\u517113\u9879\u7ecf\u6279\u51c6\u7684PD\u5e72\u7ec6\u80de\u8bd5\u9a8c<\/strong>\u6b63\u5728\u8fdb\u884c\uff0c\u672a\u67652\u20133\u5e74\uff0c\u5f53\u79fb\u690d\u7269\u6210\u719f\u540e\uff0c\u5c06\u83b7\u5f97\u5173\u952e\u7597\u6548\u6570\u636e\u3002<\/p>\n<h2><span class=\"ez-toc-section\" id=\"2_%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E8%84%8A%E9%AB%93%E6%8D%9F%E4%BC%A4%EF%BC%9A%E5%86%8D%E7%94%9F%E4%BF%AE%E5%A4%8D%E7%9A%84%E6%96%B0%E5%B8%8C%E6%9C%9B\"><\/span>2 \u5e72\u7ec6\u80de\u6cbb\u7597\u810a\u9ad3\u635f\u4f24\uff1a\u518d\u751f\u4fee\u590d\u7684\u65b0\u5e0c\u671b<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p class=\"ds-markdown-paragraph\">\u810a\u9ad3\u635f\u4f24\uff08Spinal Cord Injury, SCI\uff09\u662f\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u7684\u4e25\u91cd\u521b\u4f24\u6027\u75be\u75c5\uff0c\u5168\u7403\u60a3\u8005\u7ea61500\u4e07\uff0c\u6211\u56fd\u60a3\u8005\u8d85\u8fc7300\u4e07\uff0c\u4e14\u6bcf\u5e74\u65b0\u589e\u7ea610\u4e07\u6025\u6027\/\u4e9a\u6025\u6027\u75c5\u4f8b\u3002\u810a\u9ad3\u635f\u4f24\u591a\u89c1\u4e8e\u9752\u58ee\u5e74\uff0c\u5e38\u7531\u4ea4\u901a\u4e8b\u6545\u3001\u8fd0\u52a8\u635f\u4f24\u7b49\u5f15\u8d77\uff0c\u5177\u6709<strong>\u9ad8\u81f4\u6b8b\u7387\u3001\u4e0d\u53ef\u9006\u6027\u548c\u5e74\u8f7b\u5316<\/strong>\u7b49\u7279\u70b9\uff0c\u7ed9\u60a3\u8005\u5bb6\u5ead\u548c\u793e\u4f1a\u5e26\u6765\u6c89\u91cd\u8d1f\u62c5\u3002<\/p>\n<h3><span class=\"ez-toc-section\" id=\"21_%E7%97%85%E7%90%86%E6%8C%91%E6%88%98%E4%B8%8E%E6%B2%BB%E7%96%97%E7%AD%96%E7%95%A5\"><\/span>2.1 \u75c5\u7406\u6311\u6218\u4e0e\u6cbb\u7597\u7b56\u7565<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p class=\"ds-markdown-paragraph\">\u810a\u9ad3\u635f\u4f24\u540e\uff0c\u53d7\u635f\u8f74\u7a81\u7684<strong>\u518d\u751f\u80fd\u529b\u6781\u5176\u6709\u9650<\/strong>\uff0c\u90e8\u5206\u539f\u56e0\u662f\u635f\u4f24\u90e8\u4f4d\u5f62\u6210\u7684\u6291\u5236\u6027\u5fae\u73af\u5883\u4ee5\u53ca\u9ad3\u9798\u5f62\u6210\u7ec6\u80de\u2014\u2014\u5c11\u7a81\u80f6\u8d28\u7ec6\u80de\u7684\u4e27\u5931\u3002\u56e0\u6b64\uff0c\u4fc3\u8fdb\u8f74\u7a81\u518d\u751f\u548c\u518d\u9ad3\u9798\u5316\u6210\u4e3a\u810a\u9ad3\u635f\u4f24\u4fee\u590d\u7684\u5173\u952e\u7b56\u7565\u3002<\/p>\n<p class=\"ds-markdown-paragraph\">\u5e72\u7ec6\u80de\u6cbb\u7597\u901a\u8fc7<strong>\u66ff\u4ee3\u4e22\u5931\u7684\u7ec6\u80de\u7c7b\u578b\u3001\u63d0\u4f9b\u795e\u7ecf\u8425\u517b\u652f\u6301\u53ca\u8c03\u5236\u635f\u4f24\u540e\u708e\u75c7\u53cd\u5e94<\/strong>\u7b49\u591a\u79cd\u673a\u5236\u4fc3\u8fdb\u810a\u9ad3\u635f\u4f24\u4fee\u590d\u3002\u5176\u4e2d\uff0c\u4eba\u591a\u80fd\u5e72\u7ec6\u80de\u6765\u6e90\u7684\u5c11\u7a81\u80f6\u8d28\u524d\u4f53\u7ec6\u80de\uff08oligodendrocyte progenitor cells, OPCs\uff09\u548c\u795e\u7ecf\u524d\u4f53\u7ec6\u80de\uff08neural progenitor cells, NPCs\uff09\u662f\u4e3b\u8981\u7684\u7814\u7a76\u65b9\u5411\u3002<\/p>\n<h3><span class=\"ez-toc-section\" id=\"22_%E5%A4%9A%E8%83%BD%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E8%84%8A%E9%AB%93%E6%8D%9F%E4%BC%A4%E7%9A%84%E4%B8%B4%E5%BA%8A%E8%BD%AC%E5%8C%96%E4%B8%8E%E8%BF%9B%E5%B1%95\"><\/span>2.2 \u591a\u80fd\u5e72\u7ec6\u80de\u6cbb\u7597\u810a\u9ad3\u635f\u4f24\u7684\u4e34\u5e8a\u8f6c\u5316\u4e0e\u8fdb\u5c55<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u810a\u9ad3\u635f\u4f24\u540e\uff0c<strong data-start=\"1889\" data-end=\"1904\">\u9ad3\u9798\u5f62\u6210\u7684\u5c11\u7a81\u80f6\u8d28\u7ec6\u80de<\/strong>\u4e27\u5931\uff0c\u5bfc\u81f4\u8f74\u7a81\u5931\u53bb\u4fdd\u62a4\u4e0e\u8425\u517b\u652f\u6301\u3002\u56e0\u6b64\uff0c<strong data-start=\"1924\" data-end=\"1936\">\u66ff\u4ee3\u5c11\u7a81\u80f6\u8d28\u7ec6\u80de<\/strong>\u53ef\u80fd\u6709\u52a9\u4e8e\u4fc3\u8fdb\u8f74\u7a81\u4fee\u590d\u4e0e\u529f\u80fd\u6062\u590d\u3002\u8fd1\u5e74\u6765\uff0c\u810a\u9ad3\u635f\u4f24\u7684\u5e72\u7ec6\u80de\u6cbb\u7597\u53d6\u5f97\u4e86<strong>\u7a81\u7834\u6027\u8fdb\u5c55<\/strong>\uff0c\u7279\u522b\u662f\u5728\u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de\uff08iPSC\uff09\u884d\u751f\u7ec6\u80de\u6cbb\u7597\u9886\u57df\u3002<\/p>\n<p>2010\u5e74\uff0c\u8be5\u4ea7\u54c1\u83b7\u5f97FDA\u6279\u51c6\u8fdb\u5165\u4e34\u5e8a\uff0c\u6210\u4e3a<strong data-start=\"2098\" data-end=\"2117\">\u5168\u7403\u9996\u4e2a\u8fdb\u5165\u4eba\u4f53\u7684hPSC\u4ea7\u54c1<\/strong>\u3002\u9996\u9879I\u671f\u7814\u7a76\uff08NCT01217008\uff09\u51715\u4f8b\u6025\u6027\u80f8\u6bb5\u635f\u4f24\u60a3\u8005\uff0c10\u5e74\u5b89\u5168\u6027\u968f\u8bbf\u663e\u793a\u6cbb\u7597\u8010\u53d7\u826f\u597d\uff0c\u65e0\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\u6216\u80bf\u7624\u5f62\u6210\uff0c\u4f46\u7597\u6548\u6709\u9650\uff0c\u53ef\u80fd\u4e0e\u5242\u91cf\u504f\u4f4e\u6709\u5173\u3002Geron\u4e8e2011\u5e74\u7ec8\u6b62\u8be5\u9879\u76ee\uff0c\u968f\u540e\u6280\u672f\u8f6c\u79fb\u81f3<strong data-start=\"2219\" data-end=\"2247\">Asterias Biotherapeutics<\/strong>\u5e76\u6539\u540d\u4e3a<strong data-start=\"2251\" data-end=\"2263\">AST-OPC1<\/strong>\uff0c\u4e8e2015\u5e74\u5728\u9888\u9ad3\u635f\u4f24\u60a3\u8005\u4e2d\u542f\u52a8I\/II\u671f\u5242\u91cf\u9012\u589e\u8bd5\u9a8c\uff08NCT02302157\uff09\u3002<\/p>\n<p>\u7ed3\u679c\u663e\u793a\uff0c\u5927\u591a\u6570\u60a3\u8005\uff0896%\uff09\u6062\u590d\u4e86\u81f3\u5c11\u4e00\u4fa7\u8eab\u4f53\u7684\u4e00\u4e2a\u6216\u591a\u4e2a\u795e\u7ecf\u8282\u6bb5\u529f\u80fd\uff0c32%\u6062\u590d\u4e86\u4e24\u4e2a\u6216\u4ee5\u4e0a\u529f\u80fd\u6c34\u5e73\uff0c\u5b89\u5168\u6027\u826f\u597d\u3002\u7531\u4e8e\u6837\u672c\u91cf\u6709\u9650\uff0c\u7597\u6548\u5f52\u56e0\u5c1a\u4e0d\u660e\u786e\u3002Asterias\u540e\u88ab<strong data-start=\"2395\" data-end=\"2408\">BioTime\u516c\u53f8<\/strong>\u6536\u8d2d\u5e76\u66f4\u540d\u4e3a<strong data-start=\"2414\" data-end=\"2443\">Lineage Cell Therapeutics<\/strong>\uff0c\u4ea7\u54c1\u4ea6\u6539\u79f0<strong data-start=\"2449\" data-end=\"2461\">LCT-OPC1<\/strong>The<\/p>\n<p>\u6b64\u5916\uff0c\u65e5\u672c<strong data-start=\"2471\" data-end=\"2481\">\u5e86\u5e94\u4e49\u587e\u5927\u5b66<\/strong>\u4e0e\u97e9\u56fd<strong data-start=\"2484\" data-end=\"2499\">S.Biomedics<\/strong>\u4e5f\u5206\u522b\u5f00\u5c55\u4e86\u57fa\u4e8ehPSC\u6765\u6e90\u795e\u7ecf\u5e72\/\u524d\u4f53\u7ec6\u80de\u7684\u810a\u9ad3\u635f\u4f24\u8bd5\u9a8c\u3002\u4e24\u8005\u7684\u4f5c\u7528\u673a\u5236\u5747\u662f\u901a\u8fc7<strong data-start=\"2540\" data-end=\"2552\">\u5206\u6ccc\u795e\u7ecf\u8425\u517b\u56e0\u5b50<\/strong>\u4fc3\u8fdb\u4fee\u590d\u4e0e\u518d\u9ad3\u9798\u5316\u3002\u97e9\u56fd\u9879\u76ee\u91c7\u7528<strong data-start=\"2568\" data-end=\"2593\">hESC\u6765\u6e90PSA-NCAM+\u795e\u7ecf\u524d\u4f53\u7ec6\u80de<\/strong>\u9798\u5185\u6ce8\u5c04\uff0c\u5c1a\u65e0\u516c\u5e03\u6570\u636e\u3002<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S235232042100064X?via%3Dihub\" target=\"_blank\" rel=\"noopener nofollow\">\u5e86\u5e94\u5927\u5b66<strong data-start=\"2609\" data-end=\"2654\">\u5188\u91ce\u82f1\u4e4b\uff08Hideyuki Okano\uff09\u56e2\u961f\u5219\u5728\u5b8c\u5168\u6027\u9888\/\u80f8\u6bb5\u6025\u6027\u810a\u9ad3\u635f\u4f24<\/strong>\u60a3\u8005\u4e2d\u79fb\u690d<strong data-start=\"2659\" data-end=\"2674\">hiPSC\u6765\u6e90NSCs<\/strong><\/a>\uff08\u6bcf\u4f8b200\u4e07\u7ec6\u80de\uff09\uff0c\u76ee\u524d4\u4f8b\u53d7\u8bd5\u8005\u5747\u672a\u62a5\u544a\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\uff08\u5188\u91ce\u82f1\u4e4b\u4e2a\u4eba\u901a\u4fe1\uff09\u3002<\/p>\n<div id=\"attachment_20435\" style=\"width: 688px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-20435\" class=\"wp-image-20435 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-12_183357_397.png\" alt=\"\" width=\"678\" height=\"466\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-12_183357_397.png 678w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-12_183357_397-300x206.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-12_183357_397-18x12.png 18w\" sizes=\"(max-width: 678px) 100vw, 678px\" \/><p id=\"caption-attachment-20435\" class=\"wp-caption-text\">\u9996\u6b21\u4eba\u4f53\u4e34\u5e8a\u8bd5\u9a8c\uff1a\u79fb\u690d\u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de\u6765\u6e90\u7684\u795e\u7ecf\u5e72\u7ec6\u80de\/\u7956\u7ec6\u80de\u6cbb\u7597\u4e9a\u6025\u6027\u5b8c\u5168\u6027\u810a\u9ad3\u635f\u4f24\uff1a\u7814\u7a76\u65b9\u6848\u9996\u6b21\u4eba\u4f53\u4e34\u5e8a\u8bd5\u9a8c\uff1a\u79fb\u690d\u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de\u6765\u6e90\u7684\u795e\u7ecf\u5e72\u7ec6\u80de\/\u7956\u7ec6\u80de\u6cbb\u7597\u4e9a\u6025\u6027\u5b8c\u5168\u6027\u810a\u9ad3\u635f\u4f24\uff1a\u7814\u7a76\u65b9\u6848<\/p><\/div>\n<p class=\"ds-markdown-paragraph\">2025\u5e74\uff0c\u5168\u7403\u9996\u4e2a\u5f02\u4f53\u901a\u7528\u578b&#8221;\u73b0\u8d27\u578b&#8221;iPSC\u884d\u751f\u4e9a\u578b\u795e\u7ecf\u7ec6\u80de\u65b0\u836f\u6ce8\u518c\u4e34\u5e8a\u8bd5\u9a8c\u6b63\u5f0f\u901a\u8fc7\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u4e0e\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u7684<strong>\u4e2d\u7f8e\u53cc\u62a5\u5ba1\u6279<\/strong>\uff0c\u4e14\u5747\u83b7\u4e00\u6b21\u6027\u65e0\u53d1\u8865\u5b8c\u5168\u6279\u51c6\uff0c\u7528\u4e8e\u810a\u9ad3\u635f\u4f24\u7684\u6cbb\u7597\u3002\u8fd9\u4e00\u91cc\u7a0b\u7891\u4e8b\u4ef6\u6807\u5fd7\u7740\u6211\u56fd\u5728\u518d\u751f\u533b\u5b66\u9886\u57df\u7684\u521b\u65b0\u5b9e\u529b\u548c\u56fd\u9645\u9886\u5148\u5730\u4f4d\u3002<\/p>\n<p class=\"ds-markdown-paragraph\">\u8be5\u4e34\u5e8a\u8bd5\u9a8c\u7531\u4e2d\u5c71\u5927\u5b66\u9644\u5c5e\u7b2c\u4e09\u533b\u9662\u620e\u5229\u6c11\u6559\u6388\u548c\u5927\u8fde\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u7b2c\u4e00\u533b\u9662\u5218\u6676\u6559\u6388\u5171\u540c\u7275\u5934\uff0c\u4e8e2025\u5e747\u6708\u6b63\u5f0f\u542f\u52a8\u3002\u8fd9\u6b3eiPSC\u884d\u751f\u4e9a\u578b\u795e\u7ecf\u7ec6\u80de\u836f\u7269\u5177\u6709\u4e09\u5927\u521b\u65b0\u7279\u70b9\uff1a<\/p>\n<ul>\n<li class=\"ds-markdown-paragraph\">\u4e00\u662f&#8221;<strong>\u73b0\u8d27\u578b<\/strong>&#8220;\u4f9b\u5e94\uff0c\u5229\u7528iPSC\u6280\u672f\u5c06\u666e\u901a\u4f53\u7ec6\u80de\u91cd\u7f16\u7a0b\u4e3a\u5177\u6709\u80da\u80ce\u5e72\u7ec6\u80de\u7279\u6027\u7684\u7ec6\u80de\uff0c\u518d\u5b9a\u5411\u5206\u5316\u4e3a\u7279\u5b9a\u795e\u7ecf\u524d\u4f53\u7ec6\u80de\uff0c\u6807\u51c6\u5316\u5236\u5907\u7684\u7ec6\u80de\u5236\u5242\u53ef\u968f\u65f6\u8c03\u7528\uff0c\u4e0d\u5fc5\u4e3a\u60a3\u8005\u5355\u72ec\u5b9a\u5236\uff1b<\/li>\n<li class=\"ds-markdown-paragraph\">\u4e8c\u662f<strong>\u7cbe\u51c6\u795e\u7ecf\u4fee\u590d<\/strong>\uff0c\u4e0e\u4f20\u7edf\u5e72\u7ec6\u80de\u7597\u6cd5\u4e0d\u540c\uff0c\u8be5\u836f\u7269\u9776\u5411\u518d\u751f\u810a\u9ad3\u533a\u7684\u4e9a\u578b\u7279\u5316\u795e\u7ecf\u7ec6\u80de\uff0c\u80fd\u66f4\u7cbe\u51c6\u5730\u6574\u5408\u5230\u635f\u4f24\u90e8\u4f4d\uff0c\u91cd\u5efa\u795e\u7ecf\u4fe1\u53f7\u4f20\u5bfc\u901a\u8def\uff1b<\/li>\n<li class=\"ds-markdown-paragraph\">\u4e09\u662f<strong>\u4e2d\u7f8e\u53cc\u8ba4\u8bc1\u8d28\u63a7<\/strong>\uff0c\u4f9d\u6258\u5168\u6d41\u7a0b\u8d28\u63a7\u4f53\u7cfb\uff0c\u7ec6\u80de\u4ea7\u54c1\u540c\u65f6\u6ee1\u8db3\u4e2d\u3001\u7f8e\u836f\u54c1\u751f\u4ea7\u89c4\u8303\uff0c\u4e3a\u5168\u7403\u5e94\u7528\u94fa\u5e73\u9053\u8def\u3002<\/li>\n<\/ul>\n<p class=\"ds-markdown-paragraph\">2025\u5e747\u6708\uff0c\u8fd9\u4e00\u5168\u7403\u9996\u6b3eiPSC\u518d\u751f\u810a\u9ad3\u795e\u7ecf\u7ec6\u80de\u65b0\u836f\uff08XS228\u7ec6\u80de\u6ce8\u5c04\u6db2\uff09\u6cbb\u7597\u810a\u9ad3\u635f\u4f24\u7684\u6ce8\u518c\u4e34\u5e8aI\u671f\u7814\u7a76\u6210\u529f\u5b8c\u6210<strong>\u5168\u7403\u9996\u4f8b\u53d7\u8bd5\u8005\u7ed9\u836f<\/strong>\u3002\u636e\u62a5\u9053\uff0c\u9996\u4f8b\u53d7\u8bd5\u8005\u63a5\u53d7\u4e34\u5e8a\u7ea7iPS\u518d\u751f\u810a\u9ad3\u795e\u7ecf\u7ec6\u80de\u79fb\u690d\u540e\uff0c\u65e0\u624b\u672f\u53ca\u56f4\u672f\u671f\u7684\u5e76\u53d1\u75c7\u6216\u5176\u4ed6\u4e0d\u826f\u5b89\u5168\u4e8b\u4ef6\uff0c\u5404\u9879\u68c0\u6d4b\u6307\u6807\u6b63\u5e38\uff0c\u5e73\u7a33\u5ea6\u8fc7\u89c2\u5bdf\u671f\u5e76\u8fdb\u5165\u6b63\u5f0f\u968f\u8bbf\u671f\u3002\u8fd9\u4e00\u6210\u529f\u6848\u4f8b\u4e3a\u5168\u7403\u4e2d\u67a2\u795e\u7ecf\u635f\u4f24\u4fee\u590d\u9886\u57df\u6811\u7acb\u4e86\u91cd\u8981\u91cc\u7a0b\u7891\u3002<\/p>\n<p class=\"ds-markdown-paragraph\">\u9664\u4e86iPSC\u6765\u6e90\u7684\u7ec6\u80de\u4ea7\u54c1\uff0c\u5176\u4ed6\u7c7b\u578b\u7684\u5e72\u7ec6\u80de\u4e5f\u5728\u810a\u9ad3\u635f\u4f24\u6cbb\u7597\u4e2d\u5c55\u73b0\u51fa\u6f5c\u529b\u3002\u4f8b\u5982\uff0c\u7f8e\u56fdLineage Cell Therapeutics\u516c\u53f8\u5f00\u53d1\u7684\u4eba\u80da\u80ce\u5e72\u7ec6\u80de\u6765\u6e90\u7684\u5c11\u7a81\u80f6\u8d28\u524d\u4f53\u7ec6\u80de\u4ea7\u54c1\uff08LCT-OPC1\uff09\u5728\u9888\u9ad3\u635f\u4f24\u60a3\u8005\u4e2d\u8fdb\u884c\u7684I\/II\u671f\u5242\u91cf\u9012\u589e\u8bd5\u9a8c\u663e\u793a\uff0c\u5927\u591a\u6570\u60a3\u8005\uff0896%\uff09\u6062\u590d\u4e86\u81f3\u5c11\u4e00\u4fa7\u8eab\u4f53\u7684\u4e00\u4e2a\u6216\u591a\u4e2a\u795e\u7ecf\u8282\u6bb5\u529f\u80fd\uff0c32%\u6062\u590d\u4e86\u4e24\u4e2a\u6216\u4ee5\u4e0a\u529f\u80fd\u6c34\u5e73\uff0c\u4e14\u5b89\u5168\u6027\u826f\u597d\u3002<\/p>\n<h2><span class=\"ez-toc-section\" id=\"3_%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E7%99%AB%E7%97%AB%EF%BC%9A%E8%B0%83%E6%8E%A7%E7%A5%9E%E7%BB%8F%E7%8E%AF%E8%B7%AF%E7%9A%84%E6%96%B0%E7%AD%96%E7%95%A5\"><\/span>3 \u5e72\u7ec6\u80de\u6cbb\u7597\u766b\u75eb\uff1a\u8c03\u63a7\u795e\u7ecf\u73af\u8def\u7684\u65b0\u7b56\u7565<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p class=\"ds-markdown-paragraph\">\u766b\u75eb\u662f\u4e00\u79cd\u5e38\u89c1\u7684\u6162\u6027\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\uff0c\u5168\u7403\u60a3\u8005\u7ea66500\u4e07\uff0c\u5176\u4e2d\u7ea638%\u7684\u60a3\u8005\u4f7f\u7528\u4f20\u7edf\u6297\u766b\u75eb\u836f\u7269\u4ecd\u65e0\u6cd5\u6709\u6548\u63a7\u5236\u53d1\u4f5c\uff0c\u53d1\u5c55\u4e3a\u836f\u7269\u96be\u6cbb\u6027\u766b\u75eb\u3002\u8fd9\u4e9b\u60a3\u8005\u4e0d\u4ec5\u9762\u4e34\u53cd\u590d\u766b\u75eb\u53d1\u4f5c\u7684\u56f0\u6270\uff0c\u8fd8\u5e38\u4f34\u6709<strong>\u8bb0\u5fc6\u8870\u9000\u7b49\u8ba4\u77e5\u529f\u80fd\u969c\u788d<\/strong>\uff0c\u8feb\u5207\u9700\u8981\u65b0\u7684\u6cbb\u7597\u7b56\u7565\u3002<\/p>\n<h3><span class=\"ez-toc-section\" id=\"31_%E7%97%85%E7%90%86%E5%9F%BA%E7%A1%80%E4%B8%8E%E6%B2%BB%E7%96%97%E6%96%B0%E6%80%9D%E8%B7%AF\"><\/span>3.1 \u75c5\u7406\u57fa\u7840\u4e0e\u6cbb\u7597\u65b0\u601d\u8def<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p class=\"ds-markdown-paragraph\">\u766b\u75eb\u53d1\u4f5c\u7684\u6838\u5fc3\u673a\u5236\u662f\u5927\u8111\u795e\u7ecf\u5143<strong>\u5174\u594b\u6027\u4e0e\u6291\u5236\u6027\u5e73\u8861\u5931\u8c03<\/strong>\uff0c\u5bfc\u81f4\u5f02\u5e38\u540c\u6b65\u653e\u7535\u3002\u7279\u522b\u662f\u5728\u989e\u53f6\u766b\u75eb\u4e2d\uff0c\u6d77\u9a6c\u533a\u6291\u5236\u6027\u4e2d\u95f4\u795e\u7ecf\u5143\uff08\u5982GABA\u80fd\u795e\u7ecf\u5143\uff09\u7684\u4e22\u5931\u6216\u529f\u80fd\u5f02\u5e38\u662f\u5bfc\u81f4\u7f51\u7edc\u5174\u594b\u6027\u589e\u9ad8\u7684\u91cd\u8981\u56e0\u7d20\u3002<\/p>\n<p class=\"ds-markdown-paragraph\">\u57fa\u4e8e\u8fd9\u4e00\u8ba4\u8bc6\uff0c\u5e72\u7ec6\u80de\u6cbb\u7597\u766b\u75eb\u7684\u7b56\u7565\u4e3b\u8981\u96c6\u4e2d\u5728<strong>\u4fee\u590d\u53d7\u635f\u7684\u6291\u5236\u6027\u795e\u7ecf\u73af\u8def<\/strong>\u4e0a\uff0c\u5373\u901a\u8fc7\u79fb\u690d\u6291\u5236\u6027\u4e2d\u95f4\u795e\u7ecf\u5143\u6216\u80fd\u591f\u5206\u6ccc\u6297\u766b\u75eb\u56e0\u5b50\u7684\u7ec6\u80de\uff0c\u91cd\u5efa\u6b63\u5e38\u7684\u5174\u594b-\u6291\u5236\u5e73\u8861\u3002<\/p>\n<h3><span class=\"ez-toc-section\" id=\"32_%E4%B8%B4%E5%BA%8A%E5%89%8D%E7%A0%94%E7%A9%B6%E4%B8%8E%E4%B8%B4%E5%BA%8A%E6%8E%A2%E7%B4%A2\"><\/span>3.2 \u4e34\u5e8a\u524d\u7814\u7a76\u4e0e\u4e34\u5e8a\u63a2\u7d22<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p class=\"ds-markdown-paragraph\">\u8fd1\u5e74\u6765\uff0c\u5e72\u7ec6\u80de\u6cbb\u7597\u766b\u75eb\u9886\u57df\u53d6\u5f97\u4e86\u591a\u9879\u7a81\u7834\u6027\u8fdb\u5c55\u30022025\u5e741\u6708\uff0c\u6885\u5965\u8bca\u6240\u5ba3\u5e03\u53c2\u4e0e\u9996\u4e2a\u518d\u751f\u7597\u6cd5\u6cbb\u7597\u8010\u836f\u6027\u766b\u75eb\u7684\u4eba\u4f53\u7814\u7a76\u3002\u8fd9\u9879\u591a\u4e2d\u5fc3\u7814\u7a76\u6d4b\u8bd5\u7684\u662f\u5c06\u4e2d\u95f4\u795e\u7ecf\u5143\u79fb\u690d\u5230\u766b\u75eb\u60a3\u8005\u7684\u6d77\u9a6c\u4f53\u4e2d\uff0c\u65e8\u5728<strong>\u6062\u590d\u6b63\u5e38\u7684\u5174\u594b-\u6291\u5236\u5e73\u8861<\/strong>The<\/p>\n<p class=\"ds-markdown-paragraph\">\u6885\u5965\u8bca\u6240\u7684Jonathon J. Parker\u535a\u58eb\u89e3\u91ca\u9053\uff1a&#8221;\u8fd9\u9879\u5de5\u4f5c\u6709\u6f5c\u529b<strong>\u91cd\u5199\u766b\u75eb\u7684\u6cbb\u7597\u8def\u5f84<\/strong>\u3002\u4ece\u57fa\u7840\u5c42\u9762\u770b\uff0c\u53cd\u590d\u766b\u75eb\u53d1\u4f5c\u540e\uff0c\u6d77\u9a6c\u533a\u4e2d\u95f4\u795e\u7ecf\u5143\u5e38\u5e38\u4e22\u5931\u3002\u6211\u4eec\u5e0c\u671b\u901a\u8fc7\u66ff\u6362\u8fd9\u4e9b\u6291\u5236\u6027\u7ec6\u80de\u6765\u6062\u590d\u6b63\u5e38\u7684\u5174\u594b\u5e73\u8861\uff0c\u51cf\u5c11\u751a\u81f3\u6d88\u9664\u766b\u75eb\u53d1\u4f5c\u3002&#8221;<\/p>\n<p class=\"ds-markdown-paragraph\">\u53e6\u4e00\u9879\u503c\u5f97\u5173\u6ce8\u7684\u8fdb\u5c55\u662f\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u5916\u6ccc\u4f53\u7684\u7ecf\u9f3b\u7ed9\u836f\u7b56\u7565\u30022025\u5e744\u6708\uff0c\u7f8e\u56fd\u5f97\u514b\u8428\u65af\u519c\u5de5\u5927\u5b66\u56e2\u961f\u5728\u300aPNAS\u300b\u4e0a\u53d1\u8868\u7684\u7814\u7a76\u8868\u660e\uff0c\u901a\u8fc7\u9f3b\u8154\u6ef4\u6ce8\u5e72\u7ec6\u80de\u5916\u6ccc\u4f53\uff0c\u53ef\u5b9e\u73b0<strong>\u5bf9\u766b\u75eb\u75c5\u7076\u7684\u591a\u7ef4\u5ea6\u4fee\u590d<\/strong>\u3002\u7814\u7a76\u91c7\u7528\u6bdb\u679c\u82b8\u9999\u78b1\u8bf1\u5bfc\u7684\u766b\u75eb\u5c0f\u9f20\u6a21\u578b\uff0c\u53d1\u73b0\u7ecf\u9f3b\u6ef4\u6ce8\u7684\u5e72\u7ec6\u80de\u5916\u6ccc\u4f53\u53ef\u57286\u5c0f\u65f6\u5185\u8de8\u8d8a\u8840\u8111\u5c4f\u969c\uff0c\u7cbe\u51c6\u62b5\u8fbe\u6d77\u9a6c\u533a\u75c5\u7076\uff0c\u5e76\u6301\u7eed\u91ca\u653e\u6d3b\u6027\u6210\u520672\u5c0f\u65f6\u3002<\/p>\n<p class=\"ds-markdown-paragraph\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8fd9\u79cd<\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u9776\u5411\u9012\u9001\u65b9\u5f0f<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7ed5\u8fc7\u4e86\u9996\u8fc7\u6548\u5e94\uff0c\u663e\u7740\u63d0\u9ad8\u4e86\u751f\u7269\u5229\u7528\u5ea6\uff0c\u5e76\u901a\u8fc7\u4e09\u91cd\u673a\u5236\u53d1\u6325\u6cbb\u7597\u4f5c\u7528\uff1a\u4e00\u662f<\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u708e\u75c7\u8c03\u63a7<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff0c\u901a\u8fc7\u6291\u5236NF-\u03baB\u901a\u8def\uff0c\u4f7f\u5173\u952e\u4fc3\u708e\u56e0\u5b50TNF-\u03b1\u6c34\u5e73\u964d\u4f4e58%\uff0c\u540c\u65f6\u6fc0\u6d3bIL-10\u7b49\u4fdd\u62a4\u6027\u56e0\u5b50\uff1b\u4e8c\u662f<\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u795e\u7ecf\u5143\u4fdd\u62a4<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff0c\u6d77\u9a6cCA1\u533a\u9525\u4f53\u7ec6\u80de\u6b7b\u4ea1\u7387\u964d\u4f4e30%\uff0c\u6291\u5236\u6027\u4e2d\u95f4\u795e\u7ecf\u5143\u4fdd\u7559\u7387\u63d0\u9ad847%\uff1b\u4e09\u662f<\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u795e\u7ecf\u518d\u751f<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff0c\u6162\u6027\u671f\uff086\u5468\u540e\uff09\u6d77\u9a6c\u9f7f\u72b6\u56de\u65b0\u751f\u795e\u7ecf\u5143\u6570\u91cf\u589e\u52a02.8\u500d\uff0c\u5f02\u5e38\u8fc1\u79fb\u51cf\u5c1162%\uff0c\u540c\u65f6\u6539\u5584\u7a7a\u95f4\u8bb0\u5fc6\u548c\u8ba4\u77e5\u80fd\u529b\u3002<\/span><\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u76ee\u524d\uff0c\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u5916\u6ccc\u4f53\u6cbb\u7597\u766b\u75eb\u7684\u2160\/\u2161\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5df2\u5f00\u5c55\uff08NCT04388982\uff09\uff0c\u521d\u6b65\u7ed3\u679c\u663e\u793a\u5176<\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5b89\u5168\u6027\u826f\u597d<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u3002\u7c7b\u4f3c\u7684\u9f3b\u5185\u7ed9\u836f\u7b56\u7565\u5728\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7b49\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u4e2d\u4e5f\u5c55\u73b0\u51fa\u6f5c\u529b\uff0c\u4e3a\u836f\u7269\u96be\u6cbb\u6027\u766b\u75eb\u60a3\u8005\u63d0\u4f9b\u4e86\u65b0\u7684\u5e0c\u671b\u3002<\/span><\/span><\/p>\n<h2><span class=\"ez-toc-section\" id=\"4%E5%A4%9A%E8%83%BD%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E5%85%B6%E5%AE%83%E4%B8%AD%E6%9E%A2%E7%A5%9E%E7%BB%8F%E7%B3%BB%E7%BB%9F%E7%96%BE%E7%97%85%E7%9A%84%E4%B8%B4%E5%BA%8A%E7%A0%94%E7%A9%B6%E8%BF%9B%E5%B1%95\"><\/span><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">4.\u591a\u80fd\u5e72\u7ec6\u80de\u6cbb\u7597<\/span><\/span><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5176\u5b83\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u7684\u4e34\u5e8a\u7814\u7a76\u8fdb\u5c55<\/span><\/span><\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p data-start=\"3401\" data-end=\"3419\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5176\u4ed6\u9488\u5bf9CNS\u7684\u4e34\u5e8a\u7814\u7a76\u8fd8\u5305\u62ec\uff1a<\/span><\/span><\/p>\n<ul data-start=\"3421\" data-end=\"3797\">\n<li data-start=\"3421\" data-end=\"3540\">\n<p data-start=\"3423\" data-end=\"3540\"><a href=\"https:\/\/translational-medicine.biomedcentral.com\/articles\/10.1186\/s12967-023-03903-3\" target=\"_blank\" rel=\"noopener nofollow\"><strong data-start=\"3423\" data-end=\"3442\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4ee5\u8272\u5217KadimaStem\u516c\u53f8<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e8e2018\u5e74\u542f\u52a8\u7684ALS\uff08\u808c\u840e\u7f29\u4fa7\u7d22\u786c\u5316\u75c7\uff09\u8bd5\u9a8c<\/span><\/span><\/a><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff0c\u5c06hESC\u6765\u6e90\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\uff08AstroRx\uff09\u9798\u5185\u6ce8\u5c04\u81f3\u60a3\u8005\u810a\u9ad3\u3002 10\u540d\u60a3\u8005\u63a5\u53d7\u4e24\u79cd\u5242\u91cf\u6cbb\u7597\uff0c\u672f\u540e3\u4e2a\u6708\u75c5\u7a0b\u8fdb\u5c55\u51cf\u7f13\uff0c\u4f4612\u4e2a\u6708\u65f6\u672a\u89c1\u663e\u7740\u6539\u5584\u3002<\/span><\/span><\/p>\n<\/li>\n<li data-start=\"3541\" data-end=\"3630\">\n<p data-start=\"3543\" data-end=\"3630\"><a href=\"https:\/\/www.ahajournals.org\/doi\/abs\/10.1161\/str.54.suppl_1.147\" target=\"_blank\" rel=\"noopener nofollow\"><strong data-start=\"3543\" data-end=\"3552\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u65af\u5766\u798f\u5927\u5b66<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e8e2021\u5e74\u5f00\u5c55\u7684<\/span><\/span><strong data-start=\"3561\" data-end=\"3573\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7f3a\u8840\u6027\u76ae\u8d28\u4e0b\u4e2d\u98ce<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7814\u7a76<\/span><\/span><\/a><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff0c\u4f7f\u7528H9\u7cfbhESC\u6765\u6e90NSCs\u4ea7\u54c1\uff1b2023\u5e74\u516c\u5e03\u7684\u4e2d\u671f\u6570\u636e\u8868\u660e\uff0c\u5728\u9996\u62796\u4f8b\u60a3\u8005\u4e2d\uff0c6\u4e2a\u6708\u65f6\u8010\u53d7\u6027\u826f\u597d\u3002<\/span><\/span><\/p>\n<\/li>\n<li data-start=\"3631\" data-end=\"3797\">\n<p data-start=\"3633\" data-end=\"3797\"><strong data-start=\"3633\" data-end=\"3670\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u52a0\u5dde\u5927\u5b66\u6b27\u6587\u5206\u6821\uff08UCI\uff09\u7684Leslie Thompson<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u56e2\u961f\u5f00\u53d1\u7684<\/span><\/span><strong data-start=\"3675\" data-end=\"3688\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4ea8\u5ef7\u987f\u75c5NSC\u7597\u6cd5<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5df2\u4e8e2024\u5e74\u83b7\u5f97FDA\u6279\u51c6\u8fdb\u5165\u4e34\u5e8a\uff08L. Thompson\u4e2a\u4eba\u901a\u4fe1\uff09\u3002\u867d\u7136\u4e34\u5e8a\u5c1a\u672a\u5f00\u59cb\uff0c\u4f46\u52a8\u7269\u5b9e\u9a8c\u663e\u793a\uff0c\u8be5\u7ec6\u80de\u53ef<\/span><\/span><strong data-start=\"3745\" data-end=\"3761\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u51cf\u5c11\u7a81\u53d8\u578b\u4ea8\u5ef7\u987f\u86cb\u767d\u79ef\u805a<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5e76<\/span><\/span><strong data-start=\"3762\" data-end=\"3776\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u589e\u5f3a\u795e\u7ecf\u8425\u517b\u56e0\u5b50\u5206\u6ccc<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff0c\u6709\u52a9\u4e8e\u652f\u6301\u5185\u6e90\u6027\u795e\u7ecf\u5143\u7684\u5b58\u6d3b\u4e0e\u4fee\u590d\u3002<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<h2><span class=\"ez-toc-section\" id=\"5_%E6%8C%91%E6%88%98%E4%B8%8E%E6%9C%AA%E6%9D%A5%E6%96%B9%E5%90%91\"><\/span><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">5. \u6311\u6218\u4e0e\u672a\u6765\u65b9\u5411<\/span><\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p class=\"ds-markdown-paragraph\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5c3d\u7ba1\u591a\u80fd\u5e72\u7ec6\u80de\u6cbb\u7597\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u53d6\u5f97\u4e86\u4ee4\u4eba\u9f13\u821e\u7684\u8fdb\u5c55\uff0c\u4f46\u4ece\u5b9e\u9a8c\u5ba4\u8d70\u5411\u5e7f\u6cdb\u7684\u4e34\u5e8a\u5e94\u7528\u4ecd\u9762\u4e34\u8bf8\u591a\u6311\u6218\u3002<\/span><\/span><\/p>\n<h3><span class=\"ez-toc-section\" id=\"51_%E7%A7%91%E5%AD%A6%E6%8C%91%E6%88%98\"><\/span><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">5.1 \u79d1\u5b66\u6311\u6218<\/span><\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p class=\"ds-markdown-paragraph\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7ec6\u80de\u5b58\u6d3b\u4e0e\u6574\u5408\u6548\u7387\uff1a<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u662f\u5f71\u54cd\u6cbb\u7597\u6548\u679c\u7684\u5173\u952e\u56e0\u7d20\u3002\u79fb\u690d\u540e\u7684\u7ec6\u80de\u9700\u8981\u5728\u635f\u4f24\u73af\u5883\u4e2d\u5b58\u6d3b\uff0c\u5e76\u6709\u6548\u5730\u6574\u5408\u5230\u5bbf\u4e3b\u795e\u7ecf\u7f51\u7edc\u4e2d\uff0c\u624d\u80fd\u53d1\u6325\u529f\u80fd\u3002\u7814\u7a76\u8868\u660e\uff0c\u5728PD\u52a8\u7269\u6a21\u578b\u4e2d\uff0c\u53ea\u6709\u7ea65-20%\u7684\u79fb\u690d\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u80fd\u591f\u5b58\u6d3b\uff0c\u8fd9\u63d0\u793a\u6211\u4eec\u9700\u8981\u8fdb\u4e00\u6b65\u4f18\u5316\u7ec6\u80de\u5236\u5907\u548c\u79fb\u690d\u7b56\u7565\u3002<\/span><\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u80bf\u7624\u5f62\u6210\u98ce\u9669\uff1a<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u662fhPSCs\u884d\u751f\u7ec6\u80de\u6cbb\u7597\u5fc5\u987b\u9762\u5bf9\u7684\u5b89\u5168\u95ee\u9898\u3002\u672a\u5206\u5316\u7684\u591a\u80fd\u5e72\u7ec6\u80de\u6216\u589e\u6b96\u80fd\u529b\u5f3a\u7684\u524d\u4f53\u7ec6\u80de\u53ef\u80fd\u5728\u79fb\u690d\u540e\u5f62\u6210\u80bf\u7624\u3002\u56e0\u6b64\uff0c\u5f00\u53d1\u9ad8\u6548\u7684\u5206\u5316\u65b9\u6848\u548c\u7ec6\u80de\u7eaf\u5316\u7b56\u7565\uff0c\u786e\u4fdd\u7ec6\u80de\u4ea7\u54c1\u7684\u5747\u4e00\u6027\u548c\u7a33\u5b9a\u6027\uff0c\u662f\u964d\u4f4e\u80bf\u7624\u98ce\u9669\u7684\u5173\u952e\u3002<\/span><\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u514d\u75ab\u6392\u65a5\u53cd\u5e94\uff1a<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u540c\u6837\u4e0d\u5bb9\u5ffd\u89c6\u3002\u5c3d\u7ba1\u5927\u8111\u88ab\u8ba4\u4e3a\u662f<\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u514d\u75ab\u8c41\u514d\u5668\u5b98<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff0c\u4f46\u79fb\u690d\u7684\u5f02\u4f53\u7ec6\u80de\u4ecd\u53ef\u80fd\u5f15\u53d1\u514d\u75ab\u53cd\u5e94\uff0c\u5f71\u54cd\u7ec6\u80de\u5b58\u6d3b\u548c\u529f\u80fd\u3002\u76ee\u524d\uff0c\u5927\u591a\u6570\u4e34\u5e8a\u8bd5\u9a8c\u4f7f\u7528\u514d\u75ab\u6291\u5236\u5242\u6765\u63a7\u5236\u6392\u65a5\u53cd\u5e94\uff0c\u4f46\u957f\u671f\u514d\u75ab\u6291\u5236\u53ef\u80fd\u5e26\u6765\u611f\u67d3\u548c\u80bf\u7624\u7b49\u98ce\u9669\u3002\u4f7f\u7528\u60a3\u8005\u7279\u5f02\u6027iPSCs\uff08\u81ea\u4f53\u79fb\u690d\uff09\u6216\u5efa\u7acbHLA\u914d\u578b\u7684\u5e72\u7ec6\u80de\u5e93\u662f\u89e3\u51b3\u514d\u75ab\u6392\u65a5\u7684\u6f5c\u5728\u7b56\u7565\u3002<\/span><\/span><\/p>\n<h3><span class=\"ez-toc-section\" id=\"52_%E6%8A%80%E6%9C%AF%E4%B8%8E%E7%9B%91%E7%AE%A1%E7%93%B6%E9%A2%88\"><\/span><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">5.2 \u6280\u672f\u4e0e\u76d1\u7ba1\u74f6\u9888<\/span><\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p class=\"ds-markdown-paragraph\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5728\u751f\u4ea7\u5de5\u827a\u65b9\u9762\uff0c\u4ece\u79d1\u7814\u7ea7\u8d70\u5411\u4e34\u5e8a\u7ea7\u7684\u7ec6\u80de\u4ea7\u54c1\u751f\u4ea7\u9700\u8981\u5efa\u7acb<\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7a33\u5b9a\u3001\u53ef\u63a7\u3001\u53ef\u6269\u5c55\u7684\u5236\u9020\u5de5\u827a<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u3002\u7ec6\u80de\u4ea7\u54c1\u7684\u8d28\u91cf\u5c5e\u6027\u5fc5\u987b\u5f97\u5230\u7cbe\u786e\u9274\u5b9a\u548c\u63a7\u5236\uff0c\u786e\u4fdd\u4e0d\u540c\u6279\u6b21\u95f4\u7684\u4e00\u81f4\u6027\u548c\u7a33\u5b9a\u6027\u3002<\/span><\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u79fb\u690d\u7b56\u7565\u7684\u6807\u51c6\u5316<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e5f\u81f3\u5173\u91cd\u8981\u3002\u5305\u62ec\u7ec6\u80de\u5242\u91cf\u3001\u79fb\u690d\u8f68\u8ff9\u3001\u6ce8\u5c04\u901f\u5ea6\u7b49\u591a\u4e2a\u53c2\u6570\u90fd\u9700\u8981\u7cfb\u7edf\u4f18\u5316\uff0c\u4ee5\u6700\u5927\u7a0b\u5ea6\u63d0\u9ad8\u7ec6\u80de\u5b58\u6d3b\u5e76\u51cf\u5c11\u624b\u672f\u76f8\u5173\u635f\u4f24\u3002<\/span><\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5728\u76d1\u7ba1\u5c42\u9762\uff0c\u5e72\u7ec6\u80de\u4ea7\u54c1\u4f5c\u4e3a<\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6d3b\u7684\u836f\u7269<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff0c\u5176\u76d1\u7ba1\u6846\u67b6\u76f8\u8f83\u4e8e\u4f20\u7edf\u836f\u7269\u66f4\u4e3a\u590d\u6742\u3002\u76d1\u7ba1\u673a\u6784\u9700\u8981\u5236\u5b9a\u9002\u5e94\u7ec6\u80de\u4ea7\u54c1\u7279\u70b9\u7684\u5ba1\u8bc4\u6807\u51c6\uff0c\u5e73\u8861\u521b\u65b0\u4ea7\u54c1\u7684\u52a0\u901f\u5ba1\u6279\u548c\u98ce\u9669\u63a7\u5236\u3002<\/span><\/span><\/p>\n<h3><span class=\"ez-toc-section\" id=\"53_%E6%9C%AA%E6%9D%A5%E5%B1%95%E6%9C%9B\"><\/span><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">5.3 \u672a\u6765\u5c55\u671b<\/span><\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p class=\"ds-markdown-paragraph\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u9762\u5bf9\u8fd9\u4e9b\u6311\u6218\uff0c\u591a\u80fd\u5e72\u7ec6\u80de\u6cbb\u7597\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u7684\u672a\u6765\u53d1\u5c55\u53ef\u80fd\u5448\u73b0\u4ee5\u4e0b\u8d8b\u52bf\uff1a<\/span><\/span><\/p>\n<ul>\n<li class=\"ds-markdown-paragraph\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e00\u662f\u8d70\u5411<\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7cbe\u51c6\u533b\u7597\u4e0e\u4e2a\u4f53\u5316\u6cbb\u7597<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u3002\u968f\u7740iPSC\u6280\u672f\u548c\u57fa\u56e0\u7f16\u8f91\u6280\u672f\u7684\u53d1\u5c55\uff0c\u672a\u6765\u53ef\u80fd\u5b9e\u73b0\u57fa\u4e8e\u60a3\u8005\u7279\u5b9a\u9057\u4f20\u80cc\u666f\u7684\u4e2a\u4f53\u5316\u7ec6\u80de\u6cbb\u7597\uff0c\u7279\u522b\u662f\u5bf9\u4e8e\u9057\u4f20\u6027\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u3002<\/span><\/span><\/li>\n<li class=\"ds-markdown-paragraph\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e8c\u662f<\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8054\u5408\u6cbb\u7597\u7b56\u7565<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7684\u5e94\u7528\u3002\u5e72\u7ec6\u80de\u53ef\u80fd\u4e0e\u57fa\u56e0\u6cbb\u7597\u3001\u751f\u7269\u6750\u6599\u3001\u7269\u7406\u6cbb\u7597\u7b49\u591a\u79cd\u7b56\u7565\u76f8\u7ed3\u5408\uff0c\u534f\u540c\u4fc3\u8fdb\u795e\u7ecf\u4fee\u590d\u3002\u4f8b\u5982\uff0c\u5c06\u5e72\u7ec6\u80de\u4e0e\u652f\u67b6\u6750\u6599\u7ed3\u5408\uff0c\u4e3a\u7ec6\u80de\u63d0\u4f9b\u66f4\u9002\u5408\u5b58\u6d3b\u548c\u5206\u5316\u7684\u5fae\u73af\u5883\u3002<\/span><\/span><\/li>\n<li class=\"ds-markdown-paragraph\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e09\u662f<\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u75be\u75c5\u4fee\u9970\u4e0e\u65e9\u671f\u5e72\u9884<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u3002\u968f\u7740\u5bf9\u75be\u75c5\u65e9\u671f\u6807\u5fd7\u7269\u8ba4\u8bc6\u7684\u6df1\u5165\uff0c\u5e72\u7ec6\u80de\u6cbb\u7597\u53ef\u80fd\u9010\u6b65\u4ece\u665a\u671f\u60a3\u8005\u524d\u79fb\u5230\u75be\u75c5\u65e9\u671f\u9636\u6bb5\uff0c\u771f\u6b63\u5b9e\u73b0\u75be\u75c5\u4fee\u9970\u800c\u4e0d\u4ec5\u4ec5\u662f\u75c7\u72b6\u7f13\u89e3\u3002<\/span><\/span><\/li>\n<\/ul>\n<p class=\"ds-markdown-paragraph\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u590d\u65e6\u5927\u5b66\u7814\u7a76\u4eba\u5458\u5728\u5efa\u7acb\u7eb9\u72b6\u4f53\u4e2d\u578b\u591a\u68d8\u795e\u7ecf\u5143\u5206\u5316\u65b0\u6280\u672f\u65b9\u9762\u7684\u7a81\u7834\uff0c\u4e0d\u4ec5\u4e3a\u4ea8\u5ef7\u987f\u75c5\u7684\u7ec6\u80de\u6cbb\u7597\u63d0\u4f9b\u4e86\u7406\u8bba\u57fa\u7840\u53ca\u7ec6\u80de\u6765\u6e90\uff0c\u4e5f\u4e3a\u5176\u4ed6\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u7684\u7ec6\u80de\u6cbb\u7597\u7814\u53d1\u63d0\u4f9b\u4e86\u53ef\u501f\u9274\u7684\u6280\u672f\u8def\u5f84\u3002<\/span><\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u591a\u80fd\u5e72\u7ec6\u80de\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\u3001\u810a\u9ad3\u635f\u4f24\u548c\u766b\u75eb\u7b49\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u7684\u7814\u7a76\u5df2\u8fdb\u5165\u4e00\u4e2a\u5feb\u901f\u53d1\u5c55\u9636\u6bb5\u3002\u968f\u7740\u79d1\u5b66\u6280\u672f\u7684\u8fdb\u6b65\u548c\u4e34\u5e8a\u7ecf\u9a8c\u7684\u79ef\u7d2f\uff0c\u8fd9\u79cd\u521b\u65b0\u6cbb\u7597\u7b56\u7565\u6709\u671b\u4e3a\u4f17\u591a\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u60a3\u8005\u5e26\u6765\u5b9e\u8d28\u6027\u7684\u4e34\u5e8a\u83b7\u76ca\uff0c\u6700\u7ec8\u5b9e\u73b0\u4ece\u57fa\u7840\u7814\u7a76\u5230\u4e34\u5e8a\u5e94\u7528\u7684\u8f6c\u5316\u3002<\/span><\/span><\/p>","protected":false},"excerpt":{"rendered":"<p>\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\uff08CNS\uff09\u75be\u75c5\uff0c\u5982\u5e15\u91d1\u68ee\u75c5\u3001\u810a\u9ad3\u635f\u4f24\u4e0e\u766b\u75eb\uff0c\u56e0\u5176\u795e\u7ecf\u7ec6\u80de\u635f\u4f24\u6216\u6b7b\u4ea1\u540e\u81ea\u6211\u4fee\u590d\u80fd\u529b\u6781\u4f4e\uff0c\u4e00\u76f4\u662f\u533b\u5b66\u9886 [&hellip;]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[75],"tags":[193,158,173],"_links":{"self":[{"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/posts\/20428"}],"collection":[{"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/comments?post=20428"}],"version-history":[{"count":2,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/posts\/20428\/revisions"}],"predecessor-version":[{"id":20438,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/posts\/20428\/revisions\/20438"}],"wp:attachment":[{"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/media?parent=20428"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/categories?post=20428"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/tags?post=20428"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}