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data-spm-anchor-id=\"5176.28103460.0.i16.2f2e7551jsXvQ4\">\u810a\u9ad3\u635f\u4f24\uff08SCI\uff09\u662f\u4e00\u79cd\u5bfc\u81f4\u4e25\u91cd\u762b\u75ea\u7684\u75be\u75c5\uff0c\u5168\u7403\u7ea61500\u4e07\u4eba\u53d7\u5176\u5f71\u54cd\uff0c\u4e14\u51e0\u4e4e\u65e0\u6cd5\u81ea\u6108\u3002\u521b\u4f24\u6027\u56e0\u7d20\uff08\u5982\u8dcc\u5012\u3001\u4ea4\u901a\u4e8b\u6545\uff09\u548c\u975e\u521b\u4f24\u6027\u56e0\u7d20\uff08\u5982\u9000\u884c\u6027\u75be\u75c5\u3001\u80bf\u7624\uff09\u5747\u53ef\u5f15\u53d1SCI\uff0c\u800c\u4eba\u53e3\u8001\u9f84\u5316\u5c06\u52a0\u5267\u56e0\u8f7b\u5fae\u635f\u4f24\u5bfc\u81f4\u7684\u75c5\u4f8b\u589e\u957f\u3002\u76ee\u524d\u7f3a\u4e4f\u6709\u6548\u7597\u6cd5\uff0c\u5c3d\u7ba1\u7cd6\u76ae\u8d28\u6fc0\u7d20\u3001\u5229\u9c81\u5511\u7b49\u836f\u7269\u88ab\u63a2\u7d22\uff0c\u4f46\u7597\u6548\u8bc1\u636e\u4e0d\u8db3\u3002SCI\u75c5\u7406\u590d\u6742\u6027\u6e90\u4e8e\u810a\u9ad3\u7ed3\u6784\u7684\u7cbe\u7ec6\u6027\uff0c\u635f\u4f24\u4f4d\u7f6e\u504f\u5dee\u3001\u5e76\u53d1\u75c7\uff08\u5982\u5fc3\u7406\u72b6\u6001\u3001\u5668\u5b98\u635f\u4f24\uff09\u7b49\u56e0\u7d20\u663e\u8457\u5f71\u54cd\u6cbb\u7597\u6548\u679c\uff0c\u9700\u5927\u89c4\u6a21\u4e34\u5e8a\u8bd5\u9a8c\u6216\u4e25\u683c\u8bbe\u8ba1\u7684\u8bd5\u9a8c\u4ee5\u83b7\u5f97\u53ef\u9760\u7ed3\u679c\u3002<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%E7%BB%86%E8%83%9E%E7%A7%BB%E6%A4%8D%E7%96%97%E6%B3%95%E6%B2%BB%E7%96%97%E8%84%8A%E9%AB%93%E6%8D%9F%E4%BC%A4%E7%9A%84%E5%A4%9A%E6%A0%B7%E6%80%A7%E4%B8%8E%E6%9C%BA%E5%88%B6\"><\/span>\u7ec6\u80de\u79fb\u690d\u7597\u6cd5\u6cbb\u7597\u810a\u9ad3\u635f\u4f24\u7684\u591a\u6837\u6027\u4e0e\u673a\u5236<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p data-spm-anchor-id=\"5176.28103460.0.i15.2f2e7551jsXvQ4\">\u7ec6\u80de\u79fb\u690d\u4f5c\u4e3a\u65b0\u5174\u7597\u6cd5\uff0c<strong>\u901a\u8fc7\u66ff\u4ee3\u53d7\u635f\u7ec4\u7ec7\u6216\u8c03\u8282\u5fae\u73af\u5883\u4fee\u590dSCI<\/strong>\u3002\u80ce\u513f\u795e\u7ecf\u5e72\/\u7956\u7ec6\u80de\uff08NS\/PCs\uff09\u3001\u591a\u80fd\u5e72\u7ec6\u80de\u6765\u6e90\u7684NS\/PCs\u3001\u96ea\u65fa\u7ec6\u80de\u548c\u55c5\u9798\u7ec6\u80de\uff08OECs\uff09\u4e3b\u8981\u901a\u8fc7\u7ec4\u7ec7\u66ff\u4ee3\u673a\u5236\u8d77\u6548\uff0c\u9700\u624b\u672f\u79fb\u690d\u5e76\u4e0e\u5bbf\u4e3b\u6574\u5408\u4ee5\u91cd\u5efa\u795e\u7ecf\u56de\u8def\u3002\u96ea\u65fa\u7ec6\u80de\u548cOECs\u56e0\u4f4e\u81f4\u7624\u98ce\u9669\u6210\u4e3a\u6f5c\u5728\u9009\u62e9\u3002<strong>\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09\u5219\u901a\u8fc7\u91ca\u653e\u751f\u7269\u6d3b\u6027\u56e0\u5b50\u548c\u8c03\u8282\u514d\u75ab\u7cfb\u7edf\u6539\u5584\u5fae\u73af\u5883<\/strong>(math.) genus<span dir=\"auto\">\u56e0\u6b64\uff0cMSCs\u79fb\u690d\u5e76\u975e\u603b\u662f\u9700\u8981\u624b\u672f\uff0c\u4e14\u88ab\u8ba4\u4e3a\u5177\u6709\u8f83\u4f4e\u7684\u80bf\u7624\u53d1\u751f\u98ce\u9669\uff1b\u7136\u800c\uff0c\u5176\u529f\u80fd\u6062\u590d\u7684\u786e\u5207\u673a\u5236\u4ecd\u4e0d\u6e05\u695a<\/span><span class=\"anchor-text-container\"><span class=\"anchor-text\"><span dir=\"auto\">\u3002\u7ec6\u80de\u79fb\u690d\u7597\u6cd5\u7684\u539f\u7406<\/span><\/span><\/span><span class=\"anchor-text-container\"><span class=\"anchor-text\"><span dir=\"auto\">\u5982\u56fe1<\/span><\/span><\/span><span dir=\"auto\">respond in singing<\/span><span class=\"anchor-text-container\"><span class=\"anchor-text\"><span dir=\"auto\">Figure 2<\/span><\/span><\/span><span dir=\"auto\">\u6240\u793a\u3002<\/span><\/p>\n<div id=\"attachment_20516\" style=\"width: 545px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-20516\" class=\"wp-image-20516 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/1-s2.0-S2772529425000268-gr1.jpg\" alt=\"\" width=\"535\" height=\"343\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/1-s2.0-S2772529425000268-gr1.jpg 535w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/1-s2.0-S2772529425000268-gr1-300x192.jpg 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/1-s2.0-S2772529425000268-gr1-18x12.jpg 18w\" sizes=\"(max-width: 535px) 100vw, 535px\" \/><p id=\"caption-attachment-20516\" class=\"wp-caption-text\">\u56fe 1.\u4e0d\u540c\u7ec6\u80de\u7c7b\u578b\u79fb\u690d\u65b9\u6cd5\u7684\u5dee\u5f02\u3002<\/p><\/div>\n<div id=\"attachment_20515\" style=\"width: 701px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-20515\" class=\"wp-image-20515 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/1-s2.0-S2772529425000268-gr2.jpg\" alt=\"\u56fe 2.\u810a\u9ad3\u635f\u4f24 (SCI) \u7684\u8fdb\u5c55\u4ee5\u53ca\u4e0d\u540c\u7ec6\u80de\u7c7b\u578b\u7ec6\u80de\u79fb\u690d\u9884\u671f\u6cbb\u7597\u6548\u679c\u7684\u6f5c\u5728\u673a\u5236\u3002\u7f29\u5199\uff1a\u795e\u7ecf\u5e72\/\u7956\u7ec6\u80de (NS\/PCs)\uff1b\u55c5\u9798\u7ec6\u80de (OECs)\u3002\" width=\"691\" height=\"340\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/1-s2.0-S2772529425000268-gr2.jpg 691w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/1-s2.0-S2772529425000268-gr2-300x148.jpg 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/1-s2.0-S2772529425000268-gr2-18x9.jpg 18w\" sizes=\"(max-width: 691px) 100vw, 691px\" \/><p id=\"caption-attachment-20515\" class=\"wp-caption-text\">\u56fe 2.\u810a\u9ad3\u635f\u4f24 (SCI) \u7684\u8fdb\u5c55\u4ee5\u53ca\u4e0d\u540c\u7ec6\u80de\u7c7b\u578b\u7ec6\u80de\u79fb\u690d\u9884\u671f\u6cbb\u7597\u6548\u679c\u7684\u6f5c\u5728\u673a\u5236\u3002\u7f29\u5199\uff1a\u795e\u7ecf\u5e72\/\u7956\u7ec6\u80de (NS\/PCs)\uff1b\u55c5\u9798\u7ec6\u80de (OECs)\u3002<\/p><\/div>\n<h2 data-spm-anchor-id=\"5176.28103460.0.i17.2f2e7551jsXvQ4\"><span class=\"ez-toc-section\" id=\"%E4%B8%B4%E5%BA%8A%E7%A0%94%E7%A9%B6%E8%BF%9B%E5%B1%95%E4%B8%8E%E5%AE%89%E5%85%A8%E6%80%A7%E9%AA%8C%E8%AF%81\"><\/span>\u4e34\u5e8a\u7814\u7a76\u8fdb\u5c55\u4e0e\u5b89\u5168\u6027\u9a8c\u8bc1<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<div id=\"p0195\" class=\"u-margin-s-bottom\"><span dir=\"auto\">2006\u5e74\uff0c\u9996\u9879\u5229\u7528\u80ce\u513f\u6765\u6e90\u7684\u795e\u7ecf\u5e72\u7ec6\u80de\/\u7956\u7ec6\u80de\uff08NS\/PCs\uff09\u6cbb\u7597\u810a\u9ad3\u635f\u4f24\uff08SCI\uff09\u7684\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c\u53d1\u8868<\/span><span dir=\"auto\">\u3002\u968f\u540e\uff0c\u9996\u9879\u5229\u7528\u80da\u80ce\u5e72\u7ec6\u80de\uff08ES\u7ec6\u80de\uff09\u6765\u6e90\u7684NS\/PCs\u7684\u4e34\u5e8a\u7814\u7a76\u4e8e2009\u5e74\u542f\u52a8\u3002\u6700\u7ec8\u7ed3\u679c\uff08\u4e8e2022\u5e74\u516c\u5e03\uff09\u8bc1\u5b9e\u4e86\u8be5\u65b9\u6848\u7684\u5b89\u5168\u6027\uff0c\u4f46\u6307\u51fa\u5176\u7597\u6548\u4ecd\u9700\u8fdb\u4e00\u6b65\u8bc4\u4f30<\/span><span dir=\"auto\">\uff0c\u51f8\u663e\u4e86\u5f00\u53d1SCI\u7ec6\u80de\u7597\u6cd5\u7684\u96be\u5ea6\u3002\u6211\u4eec\u7684\u7814\u7a76\u56e2\u961f\u4e8e2020\u5e74\u542f\u52a8\u4e86\u9996\u9879\u5229\u7528\u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de\uff08iPS\u7ec6\u80de\uff09\u7684\u4e34\u5e8a\u7814\u7a76<\/span><span dir=\"auto\">\uff0c\u8be5\u7814\u7a76\u76ee\u524d\u6b63\u5728\u8fdb\u884c\u4e2d\u3002\u76ee\u524d\u5c1a\u65e0\u83b7\u5f97\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40 (FDA) \u6279\u51c6\u7684\u5e72\u7ec6\u80de\u7597\u6cd5\u53ef\u7528\u4e8e\u6cbb\u7597\u810a\u9ad3\u635f\u4f24<\/span><span dir=\"auto\">\uff1b\u7136\u800c\uff0c\u4e00\u79cd\u6d89\u53ca MSC \u7684\u7597\u6cd5\uff08\u5982\u4e0b\u6240\u8ff0\uff09\u5df2\u5728\u65e5\u672c\u83b7\u5f97\u6709\u6761\u4ef6\u7684\u516c\u5f00\u6279\u51c6<\/span><span dir=\"auto\">The<\/span><\/div>\n<div><\/div>\n<div class=\"u-margin-s-bottom\"><span dir=\"auto\">\u672c\u6587\u6982\u8ff0\u4e86\u7ec6\u80de\u79fb\u690d\u7597\u6cd5\u7684\u6700\u65b0\u8fdb\u5c55\uff0c\u91cd\u70b9\u5173\u6ce8\u53c2\u4e0e\u4e34\u5e8a\u7814\u7a76\u7684\u60a3\u8005\u3002<\/span><\/div>\n<div>\n<h2 id=\"sectitle0035\" class=\"u-h4 u-margin-l-top u-margin-xs-bottom\"><span class=\"ez-toc-section\" id=\"%E6%96%B9%E6%B3%95%E2%80%8B\"><\/span><span dir=\"auto\">\u65b9\u6cd5<\/span><span dir=\"auto\">\u200b<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<div id=\"p0205\" class=\"u-margin-s-bottom\"><span dir=\"auto\">2024\u5e745\u6708\u81f311\u6708\uff0c\u6211\u4eec\u4f7f\u7528\u5173\u952e\u8bcd\u201c\u7ec6\u80de\u79fb\u690d\u201d\u548c\u201c\u810a\u9ad3\u635f\u4f24\u201d\uff0c\u5e76\u7ed3\u5408\u201c\u4e34\u5e8a\u8bd5\u9a8c\u201d\u548c\u201c\u8fd110\u5e74\u201d\u7684\u7b5b\u9009\u6761\u4ef6\uff0c\u5728PubMed\u6570\u636e\u5e93\uff08<\/span><a class=\"anchor anchor-primary\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/\" target=\"_blank\" rel=\"noopener nofollow\"><span class=\"anchor-text-container\"><span class=\"anchor-text\"><span dir=\"auto\">https:\/\/pubmed.ncbi.nlm.nih.gov<\/span><\/span><\/span><\/a><span dir=\"auto\">\uff09\u4e2d\u68c0\u7d22\u4e86\u76f8\u5173\u4e34\u5e8a\u7814\u7a76\u3002\u68c0\u7d22\u7ed3\u679c\u5171\u83b7\u5f9734\u7bc7\u6587\u732e\u3002\u6211\u4eec\u5bf9\u6240\u6709\u6587\u732e\u8fdb\u884c\u4e86\u5ba1\u9605\uff0c\u5e76\u6392\u9664\u4e867\u7bc7\u4e0d\u76f8\u5173\u7684\u6587\u732e\u3002\u5728\u5269\u4f59\u768427\u7bc7\u6587\u732e\u4e2d\uff0c\u6211\u4eec\u6839\u636e\u5176\u9ad8\u5f71\u54cd\u529b\u3001\u79d1\u5b66\u91cd\u8981\u6027\u548c\u539f\u521b\u6027\uff0c\u9009\u62e9\u4e8617\u7bc7\u4f5c\u4e3a\u672c\u7814\u7a76\u7684\u53c2\u8003\u6587\u732e\u3002\u6b64\u5916\uff0c\u6211\u4eec\u8fd8\u4f7f\u7528\u5173\u952e\u8bcd\u201c\u810a\u9ad3\u635f\u4f24\u201d\u548c\u201c\u7ec6\u80de\u79fb\u690d\u201d\u5728\u4e16\u754c\u6700\u5927\u7684\u4e34\u5e8a\u7814\u7a76\u6ce8\u518c\u7f51\u7ad9\uff08<\/span><a class=\"anchor anchor-primary\" href=\"http:\/\/clinmicaltrials.gov\/\" target=\"_blank\" rel=\"noopener nofollow\"><span class=\"anchor-text-container\"><span class=\"anchor-text\"><span dir=\"auto\">ClinicalTrials.gov<\/span><\/span><\/span><\/a><span dir=\"auto\">\uff1b<\/span><a class=\"anchor anchor-primary\" href=\"https:\/\/clinicaltrials.gov\/\" target=\"_blank\" rel=\"noopener nofollow\"><span class=\"anchor-text-container\"><span class=\"anchor-text\"><span dir=\"auto\">https:\/\/clinicaltrials.gov<\/span><\/span><\/span><\/a><span dir=\"auto\">\uff09\u4e2d\u8fdb\u884c\u4e86\u68c0\u7d22\u3002\u540c\u65f6\uff0c\u6211\u4eec\u4e5f\u68c0\u7d22\u4e86\u8be5\u9886\u57df\u77e5\u540d\u5b66\u8005\u53d1\u8868\u7684\u4e0e\u4e0a\u8ff0\u6587\u732e\u76f8\u5173\u7684\u5176\u4ed6\u6587\u732e\uff0c\u5e76\u5c06\u5176\u4f5c\u4e3a\u672c\u7814\u7a76\u7684\u53c2\u8003\u6587\u732e\u3002<\/span><\/div>\n<\/div>\n<div>\n<h2 id=\"sectitle0040\" class=\"u-h4 u-margin-l-top u-margin-xs-bottom\"><span class=\"ez-toc-section\" id=\"%E7%A5%9E%E7%BB%8F%E5%B9%B2%E7%BB%86%E8%83%9E%E7%A5%96%E7%BB%86%E8%83%9E%EF%BC%88NSPCs%EF%BC%89%E6%B2%BB%E7%96%97%E8%84%8A%E9%AB%93%E6%8D%9F%E4%BC%A4%E7%9A%84%E4%B8%B4%E5%BA%8A%E7%A0%94%E7%A9%B6\"><\/span><span dir=\"auto\">\u795e\u7ecf\u5e72\u7ec6\u80de\/\u7956\u7ec6\u80de\uff08NS\/PCs\uff09\u6cbb\u7597\u810a\u9ad3\u635f\u4f24\u7684\u4e34\u5e8a\u7814\u7a76<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<div class=\"u-margin-s-bottom\">\n<div id=\"p0210\"><span dir=\"auto\">\u8fd1\u671f\u7814\u7a76\u8868\u660e\uff0c\u6210\u4eba\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u4e2d\u4ecd\u6b8b\u7559\u5c11\u91cf\u795e\u7ecf\u5e72\u7ec6\u80de\/\u7956\u7ec6\u80de\uff08NS\/PCs\uff09<\/span><span dir=\"auto\">\u3002\u7136\u800c\uff0c\u8fd9\u4e9b\u5e72\u7ec6\u80de\u7f3a\u4e4f\u8db3\u591f\u7684\u6d3b\u6027\u6765\u4fee\u590d\u8111\u6216\u810a\u9ad3\u635f\u4f24\u3002\u56e0\u6b64\uff0c\u81ea20\u4e16\u7eaa80\u5e74\u4ee3\u4ee5\u6765\uff0c\u65b0\u751f\u513f\u7ec4\u7ec7\u79fb\u690d\u7597\u6cd5\u5907\u53d7\u5173\u6ce8<\/span><span dir=\"auto\">\uff0c\u800c\u5229\u7528NS\/PCs\u7684\u4e34\u5e8a\u7814\u7a76\u81ea2010\u5e74\u4ee5\u6765\u4e5f\u4e00\u76f4\u5728\u79ef\u6781\u5f00\u5c55\u3002NS\/PCs\u53ef\u6765\u6e90\u4e8e\u4e09\u79cd\u9014\u5f84\uff1a\u65b0\u751f\u513f\u7ec4\u7ec7\u3001\u80da\u80ce\u5e72\u7ec6\u80de\uff08ES\u7ec6\u80de\uff09\u548c\u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de\uff08iPS\u7ec6\u80de\uff09\u3002<\/span><span class=\"anchor-text-container\"><span class=\"anchor-text\"><span dir=\"auto\">\u88681<\/span><\/span><\/span><span dir=\"auto\">\u603b\u7ed3\u4e86\u8fd1\u671f\u5173\u4e8e NS\/PC \u7684\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c<\/span><span dir=\"auto\">The<\/span><\/div>\n<\/div>\n<\/div>\n<div><\/div>\n<div>\n<div id=\"attachment_20522\" style=\"width: 2990px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-20522\" class=\"wp-image-20522 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5de5\u4f5c\u7c3f1_Sheet128.png\" alt=\"\" width=\"2980\" height=\"1426\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5de5\u4f5c\u7c3f1_Sheet128.png 2980w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5de5\u4f5c\u7c3f1_Sheet128-300x144.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5de5\u4f5c\u7c3f1_Sheet128-1024x490.png 1024w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5de5\u4f5c\u7c3f1_Sheet128-768x368.png 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5de5\u4f5c\u7c3f1_Sheet128-1536x735.png 1536w, 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class=\"ds-markdown-paragraph\"><strong>\u4eba\u591a\u80fd\u5e72\u7ec6\u80de\u6765\u6e90\u7684\u795e\u7ecf\u5e72\/\u7956\u7ec6\u80de\u6cbb\u7597\u810a\u9ad3\u635f\u4f24<\/strong><\/p>\n<p 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class=\"ds-markdown-paragraph\"><strong>ES\u7ec6\u80de\u6765\u6e90\u7684\u795e\u7ecf\u5e72\/\u7956\u7ec6\u80de<\/strong><\/p>\n<p 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\u00d7 10^6\u4e2aLTCOPC1\u7ec6\u80de\u79fb\u690d\uff0c\u5e76\u8f85\u4ee5\u4f4e\u5242\u91cf\u4ed6\u514b\u83ab\u53f8\u6cbb\u759760\u5929\u30022022\u5e74\u62a5\u9053\u768410\u5e74\u968f\u8bbf\u6570\u636e\u663e\u793a\uff0c\u672a\u53d1\u751f\u4e0eLCTOPC1\u7ec6\u80de\u76f8\u5173\u7684\u975e\u9884\u671f\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\uff08SAEs\uff09\u3002<\/p>\n<p class=\"ds-markdown-paragraph\">\u7b2c\u4e8c\u9879\u7814\u7a76\u662f\u4e00\u98791\/2\u671f\u3001\u5242\u91cf\u9012\u589e\u3001\u591a\u4e2d\u5fc3\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5e72\u9884\u63aa\u65bd\u57282015\u5e74\u81f32017\u5e74\u95f4\u5b9e\u65bd\u3002\u8be5\u7814\u7a76\u4e2d\uff0c\u62db\u52df\u4e86\u635f\u4f24\u4e25\u91cd\u7a0b\u5ea6\u4e3aAIS A\u7ea7\u6216B\u7ea7\u3001\u635f\u4f24\u8282\u6bb5\u5728C4\u81f3C7\u7684\u60a3\u8005\uff0c25\u540d\u5165\u7ec4\u60a3\u8005\u5728\u635f\u4f24\u540e21\u81f342\u5929\u5185\u63a5\u53d7\u4e86\u9ad3\u5185\u6ce8\u5c042 \u00d7 10^6\u30011 \u00d7 10^7\u62162 \u00d7 10^7\u4e2a\u7ec6\u80de\u3002\u4e3a\u8bc4\u4f30\u6cbb\u7597\u6548\u679c\uff0c\u8be5\u7814\u7a76\u7684\u610f\u5411\u6cbb\u7597\uff08ITT\uff09\u4eba\u7fa4\u5b9a\u4e49\u4e3a\u63a5\u53d71\u62162 \u00d7 10^7\u4e2a\u7ec6\u80de\u768422\u540d\u53c2\u4e0e\u8005\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u6839\u636e\u56fd\u9645\u810a\u9ad3\u635f\u4f24\u795e\u7ecf\u5b66\u5206\u7c7b\u6807\u51c6\uff08ISNCSCI\uff09\uff0c95.5%\u7684ITT\u4eba\u7fa4\u663e\u793a\u51fa\u81f3\u5c11\u4e00\u4e2a\u8fd0\u52a8\u8282\u6bb5\u8f83\u57fa\u7ebf\u6709\u6240\u6539\u5584\uff0c\u4e14\u6539\u5584\u7a0b\u5ea6\u4e0e\u7ec6\u80de\u5242\u91cf\u672a\u89c2\u5bdf\u5230\u76f8\u5173\u6027\u3002<\/p>\n<p class=\"ds-markdown-paragraph\">\u7136\u800c\uff0c\u4f5c\u8005\u603b\u7ed3\u79f0\uff0c\u7531\u4e8e\u6837\u672c\u91cf\u5c0f\uff0c\u5f88\u96be\u5c06\u6062\u590d\u7a0b\u5ea6 specifically \u5f52\u56e0\u4e8e\u7ec6\u80de\u7597\u6cd5\u8fd8\u662f\u81ea\u7136\u6062\u590d\u3002\u4ed6\u4eec\u5efa\u8bae\u7ed3\u5408\u5eb7\u590d\u8bad\u7ec3\u8fdb\u884c\u8fdb\u4e00\u6b65\u7814\u7a76\uff0c\u5e76\u91c7\u7528\u65b0\u7b56\u7565\u4ee5\u6700\u5927\u5316\u7ec6\u80de\u6cbb\u7597\u7684\u76ca\u5904 (Fessler et al., 2022)\u3002\u810a\u9ad3\u635f\u4f24\u60a3\u8005\u53d7\u4f24\u540e\u7ea6\u4e09\u4e2a\u6708\u5185\u4ecd\u53ef\u80fd\u53d1\u751f\u81ea\u53d1\u6027\u795e\u7ecf\u529f\u80fd\u6062\u590d\uff0c\u8fd9\u51f8\u663e\u4e86\u8bbe\u7acb\u5bf9\u7167\u7ec4\u4ee5\u51c6\u786e\u786e\u5b9a\u6cbb\u7597\u6548\u679c\u7684\u7684\u5fc5\u8981\u6027\uff0c\u5c24\u5176\u662f\u5728\u6cbb\u7597\u4e9a\u6025\u6027\u671f\u60a3\u8005\u65f6\u3002<\/p>\n<p class=\"ds-markdown-paragraph\"><strong>iPS\u7ec6\u80de\u6765\u6e90\u7684\u795e\u7ecf\u5e72\/\u7956\u7ec6\u80de\u6cbb\u7597\u810a\u9ad3\u635f\u4f24<\/strong><\/p>\n<p class=\"ds-markdown-paragraph\">\u5728\u65e5\u672c\uff0c\u4e00\u9879\u540d\u4e3a\u201c\u4f7f\u7528iPSC\u6765\u6e90\u7684\u795e\u7ecf\u7956\u7ec6\u80de\u6cbb\u7597\u4e9a\u6025\u6027\u810a\u9ad3\u635f\u4f24\u7684\u518d\u751f\u533b\u5b66\u201d\uff08UMIN000035074\uff09\u7684\u4e34\u5e8a\u7814\u7a76\u6b63\u5728\u8fdb\u884c\u4e2d (Sugai et al., 2021)\u3002\u8be5\u8bd5\u9a8c\u65e8\u5728\u805a\u7126\u4e8e\u5c06\u4f9b\u4f53iPS\u7ec6\u80de\u6765\u6e90\u7684NS\/PCs\u79fb\u690d\u5230\u56db\u540d\u4e9a\u6025\u6027\u5b8c\u5168\u6027\u810a\u9ad3\u635f\u4f24\uff08AIS-A\u7ea7\uff09\u60a3\u8005\u4f53\u5185\u7684\u6548\u679c\u3002\u56db\u540d\u635f\u4f24\u8282\u6bb5\u5728C3\/4\u81f3T10\u4e4b\u95f4\u7684\u60a3\u8005\u5728\u635f\u4f24\u540e24\u5929\u5185\u5165\u7ec4\u3002<\/p>\n<p class=\"ds-markdown-paragraph\">\u8be5\u7814\u7a76\u9075\u5faa\u65e5\u672c\u539a\u751f\u52b3\u52a8\u7701\u6279\u51c6\u7684\u65b9\u6848\uff0c\u5e76\u5728\u65e5\u672c\u4e34\u5e8a\u8bd5\u9a8c\u6ce8\u518c\u4e2d\u5fc3\uff08jRCT\uff1b\u8bd5\u9a8c\u7f16\u53f7jRCTa031190228\uff09\u6ce8\u518c\u3002\u6b64\u9879\u7814\u7a76\u662f\u9996\u4e2a\u4f7f\u7528iPS\u6765\u6e90\u7ec6\u80de\u6cbb\u7597\u810a\u9ad3\u635f\u4f24\u7684\u7814\u7a76\u3002\u4f7f\u7528iPS\u7ec6\u80de\u7684\u4e00\u4e2a\u987e\u8651\u662f\u5b83\u4eec\u53ef\u80fd\u56e0\u57fa\u56e0\u7a81\u53d8\u548c\u9057\u4f20\u4e0d\u7a33\u5b9a\u6027\u800c\u663e\u793a\u5f02\u5e38\u589e\u6b96 (Sugai et al., 2016)\u3002\u4e3a\u964d\u4f4e\u79fb\u690d\u540e\u5f02\u5e38\u589e\u6b96\u7684\u98ce\u9669\uff0c\u4e34\u5e8a\u7814\u7a76\u4e2d\u4f7f\u7528\u7684\u7ec6\u80de\u7ecf\u8fc7\u4e86\u4e25\u683c\u68c0\u67e5\uff0c\u5305\u62ec\u67d3\u8272\u4f53\u5206\u6790\u3001\u9057\u4f20\u5206\u6790\u548c\u4f53\u5185\u8bc4\u4f30\u3002\u6b64\u5916\uff0c\u8fd8\u4f7f\u7528\u4e86\u03b3-\u5206\u6ccc\u9176\u6291\u5236\u5242\u4ee5\u8fdb\u4e00\u6b65\u4fc3\u8fdb\u7ec6\u80de\u5206\u5316 (Okubo et al., 2016)\u3002\u9996\u540d\u60a3\u8005\u4e8e2020\u5e74\u63a5\u53d7\u79fb\u690d\uff0c\u7814\u7a76\u62a5\u544a\u5b8c\u6210\u4e8e2024\u5e7411\u6708\u3002\u622a\u81f3\u76ee\u524d\uff0c\u672a\u89c2\u5bdf\u5230\u4e0e\u6cbb\u7597\u76f8\u5173\u7684\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\u3002<\/p>\n<h2 id=\"sectitle0065\" class=\"u-h4 u-margin-l-top u-margin-xs-bottom\"><span class=\"ez-toc-section\" id=\"%E9%97%B4%E5%85%85%E8%B4%A8%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E8%84%8A%E9%AB%93%E6%8D%9F%E4%BC%A4\"><\/span><span dir=\"auto\">\u95f4<\/span><span dir=\"auto\">\u5145\u8d28\u5e72\u7ec6\u80de<strong>\u6cbb\u7597\u810a\u9ad3\u635f\u4f24<\/strong><\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<div class=\"u-margin-s-bottom\">\n<div id=\"p0255\"><span dir=\"auto\">\u795e\u7ecf\u5e72\u7ec6\u80de\/\u7956\u7ec6\u80de\u901a\u5e38\u91c7\u7528\u75c5\u7076\u5185\u79fb\u690d\uff0c\u800c\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u901a\u5e38\u91c7\u7528\u9798\u5185\u6216\u9759\u8109\u79fb\u690d\u3002\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u53ef\u4ece\u9aa8\u9ad3\u3001\u8102\u80aa\u7ec4\u7ec7\u6216\u8110\u5e26\u8840\u63d0\u53d6\u7269\u4e2d\u6269\u589e\u83b7\u5f97\u3002\u79fb\u690d\u7684\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u88ab\u8ba4\u4e3a\u901a\u8fc7\u5f52\u5de2\u81f3\u53d7\u635f\u90e8\u4f4d\uff0c\u5e76\u5229\u7528\u795e\u7ecf\u8425\u517b\u56e0\u5b50\u8bf1\u5bfc\u795e\u7ecf\u8425\u517b\u548c\u4fdd\u62a4\u4f5c\u7528\u4ee5\u53ca\u6297\u708e\u4f5c\u7528\u6765\u53d1\u6325\u4f5c\u7528\u3002\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u901a\u8fc7\u7a33\u5b9a\u8840\u810a\u9ad3\u5c4f\u969c\uff0c\u5e76\u521b\u9020\u6709\u5229\u4e8e\u518d\u751f\u7684\u73af\u5883\uff0c\u95f4\u63a5\u4fc3\u8fdb\u795e\u7ecf\u518d\u751f\u548c\u9ad3\u9798\u518d\u751f\uff0c\u4ece\u800c\u53d1\u6325\u795e\u7ecf\u4fdd\u62a4\u4f5c\u7528\u3002\u4e0e\u795e\u7ecf\u5e72\u7ec6\u80de\/\u7956\u7ec6\u80de\u76f8\u6bd4\uff0c\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09\u7684\u6765\u6e90\u66f4\u4e3a\u4e30\u5bcc\uff0c\u76ee\u524d\u5df2\u6709\u591a\u4e2aMSCs\u4e34\u5e8a\u8bd5\u9a8c\u6b63\u5728\u8fdb\u884c\u4e2d\uff0c\u5176\u4e2d\u4e00\u4e9b\u5df2\u8fdb\u5165II\u671f\u6216III\u671f\u3002<\/span><\/div>\n<div><\/div>\n<div><span class=\"anchor-text-container\"><span class=\"anchor-text\"><span dir=\"auto\">\u88682<\/span><\/span><\/span><span dir=\"auto\">\u603b\u7ed3\u4e86\u8fd9\u4e9b\u4e34\u5e8a\u8bd5\u9a8c\u7684\u6700\u65b0\u62a5\u544a<\/span><span dir=\"auto\">\u3002\u5927\u591a\u6570\u7814\u7a76\u8868\u660eMSCs\u7597\u6548\u6709\u9650\uff1b\u7136\u800c\uff0c\u8fd1\u671f\u4e5f\u62a5\u9053\u4e86\u4e00\u4e9b\u53ef\u80fd\u6709\u6548\u7684\u6cbb\u7597\u65b9\u6cd5\u3002\u6570\u636e\u8868\u660e\uff0cMSCs\u53ef\u80fd\u901a\u8fc7\u8425\u517b\u56e0\u5b50\u53d1\u6325\u4f5c\u7528\u3002\u6b64\u5916\uff0c\u6700\u8fd1\u51fa\u73b0\u4e86\u53ef\u80fd\u6709\u6548\u7684\u57fa\u4e8eMSC\u5916\u6ccc\u4f53\u7684\u65b0\u578b\u65b9\u6cd5<\/span><span dir=\"auto\">The<\/span><\/div>\n<div><\/div>\n<\/div>\n<div>\n<div id=\"attachment_20524\" style=\"width: 3044px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-20524\" class=\"wp-image-20524 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5de5\u4f5c\u7c3f2_Sheet11.png\" alt=\"\" width=\"3034\" height=\"2570\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5de5\u4f5c\u7c3f2_Sheet11.png 3034w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5de5\u4f5c\u7c3f2_Sheet11-300x254.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5de5\u4f5c\u7c3f2_Sheet11-1024x867.png 1024w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5de5\u4f5c\u7c3f2_Sheet11-768x651.png 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5de5\u4f5c\u7c3f2_Sheet11-1536x1301.png 1536w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5de5\u4f5c\u7c3f2_Sheet11-2048x1735.png 2048w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5de5\u4f5c\u7c3f2_Sheet11-14x12.png 14w\" sizes=\"(max-width: 3034px) 100vw, 3034px\" \/><p id=\"caption-attachment-20524\" class=\"wp-caption-text\">\u88682.\u8fd1\u671f\u6d89\u53ca\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6cbb\u7597\u810a\u9ad3\u635f\u4f24\u7684\u4e3b\u8981\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/p><\/div>\n<div><\/div>\n<div id=\"p0260\" class=\"u-margin-s-bottom\"><span dir=\"auto\">\u5728\u65e5\u672c\uff0c\u518d\u751f\u533b\u5b66\u4ea7\u54c1Stemirac\u5df2\u88ab\u539a\u751f\u52b3\u52a8\u7701\u8ba4\u5b9a\u5bf9\u4e9a\u6025\u6027\u810a\u9ad3\u635f\u4f24\uff08SCI\uff09\u60a3\u8005\u6709\u6548\uff0c\u5e76\u7eb3\u5165\u6709\u6761\u4ef6\u533b\u4fdd\u62a5\u9500\u8303\u56f4\u3002\u636e\u6211\u4eec\u6240\u77e5\uff0cStemirac\u662f\u76ee\u524d\u5168\u7403\u552f\u4e00\u7eb3\u5165\u56fd\u5bb6\u533b\u4fdd\u62a5\u9500\u8303\u56f4\u7684SCI\u6cbb\u7597\u836f\u7269\u3002Stemirac\u7684\u539f\u6599\u5305\u62ec\u60a3\u8005\u7684\u9aa8\u9ad3\u6db2\u548c\u8840\u6e05\u3002\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09\u53d6\u81ea\u60a3\u8005\u7684\u9aa8\u9ad3\uff0c\u57f9\u517b\u57fa\u5219\u7531\u60a3\u8005\u7684\u8840\u6e05\u914d\u5236\u800c\u6210\u3002\u7ecf\u8fc72-3\u5468\u7684\u4f53\u5916\u57f9\u517b\uff0c\u60a3\u8005\u9aa8\u9ad3\u6765\u6e90\u7684MSCs\u6269\u589e\u7ea61\u4e07\u500d\uff08\u81f31\u4ebf\u4e2a\u7ec6\u80de\uff09\uff0c\u4e4b\u540e\u8fdb\u884c\u5b89\u5168\u6027\u548c\u8d28\u91cf\u68c0\u6d4b\uff0c\u7136\u540e\u56de\u8f93\u7ed9\u60a3\u8005\u3002\u7ec6\u80de\u901a\u8fc7\u5916\u5468\u9759\u8109\u8f93\u6ce8\uff0c\u8f93\u6ce8\u8fc7\u7a0b\u5927\u7ea6\u9700\u898160\u5206\u949f\u3002<\/span><\/div>\n<div><\/div>\n<div id=\"p0265\" class=\"u-margin-s-bottom\"><span dir=\"auto\">\u5728\u4e0a\u5e02\u524d\u8bd5\u9a8c\u4e2d\uff0c<strong>MSC\u8f93\u6ce86\u4e2a\u6708\u540e\uff0c13\u4f8b\u60a3\u8005\u4e2d\u670912\u4f8b\u6839\u636eAIS\u8bc4\u5206\u663e\u793a\u51fa\u795e\u7ecf\u529f\u80fd\u6539\u5584\u3002MSC\u8f93\u6ce8\u524dAIS A\u7ea7\u76846\u4f8b\u60a3\u8005\u4e2d\uff0c5\u4f8b\u6539\u5584\u81f3AIS B\u7ea7\uff083\/6\uff09\u6216AIS C\u7ea7\uff082\/6\uff09\uff0c2\u4f8bAIS B\u7ea7\u60a3\u8005\u6539\u5584\u81f3AIS C\u7ea7\uff081\/2\uff09\u6216AIS D\u7ea7\uff081\/2\uff09\uff0c5\u4f8bAIS C\u7ea7\u60a3\u8005\u529f\u80fd\u72b6\u6001\u6539\u5584\u81f3AIS D\u7ea7\uff085\/5\uff09<\/strong><\/span><span dir=\"auto\">\u3002\u57fa\u4e8e\u8fd9\u4e9b\u7ed3\u679c\uff0cStemirac\u83b7\u6279\u7528\u4e8eAIS\u5206\u7ea7\u4e3aA\u3001B\u6216C\u7ea7\u7684\u4e9a\u6025\u6027\u521b\u4f24\u6027\u810a\u9ad3\u635f\u4f24\u3002\u8be5\u6279\u51c6\u5f15\u8d77\u4e86\u5168\u7403\u5173\u6ce8\uff0c\u5e76\u5f15\u53d1\u4e86\u5173\u4e8e\u662f\u5426\u5e94\u63a5\u53d7\u8be5\u6279\u51c6\u7684\u8ba8\u8bba<\/span><span dir=\"auto\">\u3002\u7531\u4e8e\u8be5\u836f\u7269\u7684\u83b7\u6279\u662f\u6709\u6761\u4ef6\u4e14\u6709\u65f6\u9650\u7684\uff0c\u76ee\u524d\u65e5\u672c\u53ea\u6709\u5c11\u6570\u533b\u9662\u5f00\u59cb\u4f7f\u7528Stemirac\u6cbb\u7597\u60a3\u8005\uff0c\u4e14\u6cbb\u7597\u540e\u957f\u8fbe1\u5e74\u7684\u6570\u636e\u4ecd\u5728\u6536\u96c6\u4e2d\u3002\u6b64\u5916\uff0c\u76ee\u524d\u7684\u83b7\u6279\u4ec5\u9650\u4e8e\u4f24\u540e31\u5929\u5185\u5904\u4e8e\u6025\u6027\u671f\u7684\u60a3\u8005\uff0c\u8fd9\u4f7f\u5f97\u8bb8\u591a\u6162\u6027\u810a\u9ad3\u635f\u4f24\u60a3\u8005\u65e0\u6cd5\u53d7\u76ca\u4e8e\u6b64\u7597\u6cd5\u3002\u975e\u4e34\u5e8a\u8bd5\u9a8c<\/span><span dir=\"auto\">\u663e\u793a\u8be5\u836f\u7269\u5728\u6162\u6027\u671f\u6a21\u578b\u4e2d\u6709\u6548\uff0c\u56e0\u6b64\u76ee\u524d\u6b63\u5728\u8fdb\u884c\u4e00\u9879\u9488\u5bf9\u6162\u6027\u671f\u60a3\u8005\u7684\u4e34\u5e8a\u7814\u7a76\uff08jRCT2013230003\uff09\u3002<\/span><\/div>\n<div><\/div>\n<div id=\"p0270\" class=\"u-margin-s-bottom\"><span dir=\"auto\">\u53e6\u4e00\u9879\u5728\u65e5\u672c\u5f00\u5c55\u7684\u4e34\u5e8a\u7814\u7a76\u5229\u7528\u4e00\u79cd\u88ab\u79f0\u4e3a\u591a\u7cfb\u5206\u5316\u5e94\u6fc0\u8010\u53d7\uff08Muse\uff09\u7ec6\u80de\u7684\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u4e9a\u578b\u53d6\u5f97\u4e86\u79ef\u6781\u6210\u679c\u3002Muse\u7ec6\u80de\u662f\u5185\u6e90\u6027\u591a\u80fd\u9aa8\u9ad3\u5e72\u7ec6\u80de\uff0c\u5176\u8868\u9762\u6807\u5fd7\u7269\u9636\u6bb5\u7279\u5f02\u6027\u80da\u80ce\u6297\u539f-3\uff08SEA-3\uff09\u7684\u9633\u6027\u7387\u7ea6\u4e3a0.03%<\/span><span dir=\"auto\">\u3002\u5b83\u4eec\u4e0d\u5177\u6709\u81f4\u7624\u6027\uff0c\u5e76\u5177\u6709\u591a\u5411\u5206\u5316\u6f5c\u80fd\u548c\u81ea\u6211\u590d\u5236\u80fd\u529b\u3002\u7531\u4e8eMuse\u7ec6\u80de\u5929\u7136\u5b58\u5728\u4e8e\u4eba\u4f53\u5185\uff0c\u56e0\u6b64\u5176\u53d1\u751f\u80bf\u7624\u7684\u98ce\u9669\u6781\u4f4e\uff0c\u4f7f\u5176\u6210\u4e3a\u9488\u5bf9\u5305\u62ec\u8111\u6897\u6b7b\u3001\u6025\u6027\u5fc3\u808c\u6897\u6b7b\u548c\u808c\u840e\u7f29\u4fa7\u7d22\u786c\u5316\u75c7\u5728\u5185\u7684\u591a\u79cd\u75be\u75c5\u8fdb\u884c\u4e34\u5e8a\u8bd5\u9a8c\u7684\u7406\u60f3\u5019\u9009\u7ec6\u80de\u3002<\/span><\/div>\n<div><\/div>\n<div class=\"u-margin-s-bottom\"><span dir=\"auto\">\u5728\u4e00\u9879\u9488\u5bf9\u810a\u9ad3\u635f\u4f24\uff08SCI\uff09\u7684\u4e34\u5e8a\u7814\u7a76\u4e2d\uff0c10\u540d\u9888\u690e\u810a\u9ad3\u635f\u4f24\u60a3\u8005\uff08\u6539\u826fFrankel\u5206\u7ea7\u4e3aB1\u6216B2\u7ea7\uff09\u63a5\u53d7\u4e86\u5355\u6b21\u5f02\u4f53CL2020\u7ec6\u80de\uff081.5 \u00d7 10\u2077\u4e2a\u7ec6\u80de\uff09\u8f93\u6ce8\uff0c<\/span><span dir=\"auto\">CL2020\u662f\u4e00\u79cd\u57fa\u4e8eMuse\u7ec6\u80de\u7684\u3001\u7531\u4eba\u6e90\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSC\uff09\u884d\u751f\u7684\u4ea7\u54c1\uff08JRCT1080224764\uff09<\/span><span dir=\"auto\">\u3002\u4ed6\u4eec\u7684ISNCSCI\u8fd0\u52a8\u8bc4\u5206\u3001\u65e5\u5e38\u751f\u6d3b\u6d3b\u52a8\u80fd\u529b\u8bc4\u5206\u548c\u751f\u6d3b\u8d28\u91cf\u8bc4\u5206\u5747\u663e\u8457\u9ad8\u4e8e\u76f8\u5e94\u7684\u57fa\u7ebf\u503c\u3002\u5c3d\u7ba1\u8003\u8651\u5230\u81ea\u7136\u6062\u590d\u7684\u53ef\u80fd\u6027\uff0c\u96be\u4ee5\u8bc4\u4f30\u8be5\u7814\u7a76\u7684\u6709\u6548\u6027\uff0c\u4f46<\/span><a class=\"anchor anchor-primary\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2772529425000268#bib22\" name=\"bbib22\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib22\" rel=\"nofollow noopener\" target=\"_blank\"><span class=\"anchor-text-container\"><span class=\"anchor-text\"><span dir=\"auto\">Koda\u7b49\u4eba\uff082024\uff09<\/span><\/span><\/span><\/a><span dir=\"auto\">\u5f97\u51fa\u7ed3\u8bba\uff0cCL2020\u7684\u6548\u679c\u4e0eHonmou\u7b49\u4eba\u62a5\u9053\u7684Stemirac\u7684\u6548\u679c\u76f8\u5f53<\/span><span dir=\"auto\">\u3002\u5c3d\u7ba1\u7ed3\u679c\u79ef\u6781\uff0c\u4f46\u7533\u529e\u65b9\u5df2\u64a4\u56de\u8be5\u7814\u7a76\uff0c\u76ee\u524d\u5c1a\u65e0\u7ee7\u7eed\u5f00\u5c55\u8be5\u7814\u7a76\u7684\u8ba1\u5212\u3002<\/span><\/div>\n<div><\/div>\n<div class=\"u-margin-s-bottom\"><span dir=\"auto\">\u897f\u73ed\u7259\u666e\u57c3\u5c14\u5854\u5fb7\u8036\u7f57\u5927\u5b66\u533b\u9662\u795e\u7ecf\u7ec6\u80de\u6cbb\u7597\u5c0f\u7ec4\u62a5\u544a\u4e86\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSC\uff09\u79fb\u690d\u7684\u7597\u6548\u3002\u4ed6\u4eec\u5f00\u5c55\u4e86\u4e34\u5e8a\u7814\u7a76\uff0c\u91c7\u7528\u4e0d\u540c\u65b9\u6848\u591a\u6b21\u79fb\u690d\u81ea\u4f53\u9aa8\u9ad3MSC\uff0c\u6cbb\u7597\u6162\u6027\u810a\u9ad3\u635f\u4f24\uff08SCI\uff09\u60a3\u8005\u3002\u57282016\u5e74\u53d1\u8868\u7684\u4e00\u9879\u7814\u7a76\uff08NCT01909154\uff09\u4e2d\uff0c12\u540d\u6162\u6027\u5b8c\u5168\u6027SCI\u60a3\u8005\uff08\u5e73\u5747\u75c5\u7a0b\uff1a13.86\u5e74\uff09\u63a5\u53d7\u4e86\u75c5\u7076\u5185\u548c\u9798\u5185\u6ce8\u5c04MSC\u6cbb\u7597\uff08\u6bcf\u4f8b\u60a3\u80051.3 \u00d7 10\u2078<\/span><sup><span dir=\"auto\">\u81f3<\/span><\/sup><span dir=\"auto\">2.3 \u00d7 10\u2078<\/span><sup><span dir=\"auto\">\u4e2a<\/span><\/sup><span dir=\"auto\"> \u7ec6\u80de\uff09\uff0c\u6ce8\u5c04\u5242\u91cf\u6839\u636e\u78c1\u5171\u632f\u6210\u50cf\u786e\u5b9a\u7684\u7591\u4f3c\u635f\u4f24\u5927\u5c0f\u800c\u5b9a<\/span><span dir=\"auto\">\u3002\u57282017\u5e74\u53d1\u8868\u7684\u53e6\u4e00\u9879\u7814\u7a76\uff08NCT02165904\uff09\u4e2d\uff0c10\u540d\u4e0d\u5b8c\u5168\u6027\u810a\u9ad3\u635f\u4f24\uff08SCI\uff09\u60a3\u8005\u63a5\u53d7\u4e864\u6b21\u9798\u5185\u6ce8\u5c04\uff0c\u6bcf\u6b21\u6ce8\u5c043.0 \u00d7\u00a0<\/span><sup><span dir=\"auto\">10\u2077<\/span><\/sup><span dir=\"auto\">\u4e2a\u95f4<\/span><span dir=\"auto\">\u5145\u8d28\u5e72\u7ec6\u80de\uff08 MSCs\uff09\uff08\u6bcf\u4f4d\u60a3\u8005\u51711.2 \u00d7 10\u2078<\/span><sup><span dir=\"auto\">\u4e2a<\/span><\/sup><span dir=\"auto\">MSCs\uff09<\/span><span dir=\"auto\">\u30022018\u5e74\u53d1\u8868\u7684\u53e6\u4e00\u9879\u7814\u7a76\uff08NCT02570932\uff09\u63cf\u8ff0\u4e86\u5bf911\u540d\u6162\u6027SCI\u60a3\u8005\u8fdb\u884c3\u6b21\u9798\u5185\u6ce8\u5c04\uff0c\u6bcf\u6b21\u6ce8\u5c041.0 \u00d7\u00a0<\/span><sup><span dir=\"auto\">10\u2078<\/span><\/sup><span dir=\"auto\">\u4e2aMSCs<\/span><span dir=\"auto\">\u3002\u5c3d\u7ba1\u4f5c\u8005\u62a5\u544a\u4e86\u6bcf\u79cd\u65b9\u6cd5\u7684\u7597\u6548\uff0c\u4f46\u7ec6\u80de\u79fb\u690d\u7814\u7a76\u5f88\u5c11\u8bc1\u5b9e\u5176\u5bf9\u6162\u6027SCI\u60a3\u8005\u7684\u6cbb\u7597\u6548\u679c\u3002\u6b64\u5916\uff0c\u8be5\u56e2\u961f\u5c1a\u672a\u5411<\/span><a class=\"anchor anchor-primary\" href=\"http:\/\/clinicaltrials.gov\/\" target=\"_blank\" rel=\"noopener nofollow\"><span class=\"anchor-text-container\"><span class=\"anchor-text\"><span dir=\"auto\">ClinicalTrials.gov<\/span><\/span><\/span><\/a><span dir=\"auto\">\u63d0\u4ea4\u4efb\u4f55\u4e34\u5e8a\u8bd5\u9a8c\u7533\u8bf7\uff0c\u5176\u7814\u7a76\u8fdb\u5c55\u60c5\u51b5\u4e0d\u660e\u3002<\/span><\/div>\n<\/div>\n<div>\n<h2 id=\"sectitle0070\" class=\"u-h4 u-margin-l-top u-margin-xs-bottom\"><span class=\"ez-toc-section\" id=\"%E9%9B%AA%E6%97%BA%E6%B0%8F%E7%BB%86%E8%83%9E\"><\/span><span dir=\"auto\">\u96ea\u65fa<\/span><span dir=\"auto\">\u6c0f<\/span><span dir=\"auto\">\u7ec6\u80de<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<div id=\"p0285\" class=\"u-margin-s-bottom\"><span dir=\"auto\">\u96ea\u65fa\u7ec6\u80de\u5f62\u6210\u5e76\u7ef4\u6301\u5305\u88f9\u5468\u56f4\u795e\u7ecf\u8f74\u7a81\u7684\u9ad3\u9798\uff0c\u5e76\u4ea7\u751f\u5bf9\u7ef4\u6301\u8fd0\u52a8\u795e\u7ecf\u5143\u548c\u611f\u89c9\u795e\u7ecf\u5143\u81f3\u5173\u91cd\u8981\u7684\u7ec6\u80de\u56e0\u5b50\u3002\u6b64\u5916\uff0c\u96ea\u65fa\u7ec6\u80de\u5728\u795e\u7ecf\u635f\u4f24\u540e\u7684\u8f74\u7a81\u518d\u751f\u8fc7\u7a0b\u4e2d\u53d1\u6325\u7740\u5f15\u5bfc\u548c\u4fee\u590d\u8f74\u7a81\u7684\u91cd\u8981\u4f5c\u7528<\/span><span dir=\"auto\">\u3002\u96ea\u65fa\u7ec6\u80de\u88ab\u8ba4\u4e3a\u662f\u4fee\u590d\u795e\u7ecf\u7cfb\u7edf\u635f\u4f24\u7684\u6f5c\u5728\u79fb\u690d\u7597\u6cd5\u5019\u9009\u7ec6\u80de\u3002\u7136\u800c\uff0c\u7531\u4e8e\u7ec4\u7ec7\u57f9\u517b\u56f0\u96be\u4ee5\u53ca\u5bf9\u795e\u7ecf\u83b7\u53d6\u4fb5\u5165\u6027\u7684\u62c5\u5fe7\uff0c\u9488\u5bf9\u8be5\u7597\u6cd5\u7684\u4e34\u5e8a\u7814\u7a76\u8f83\u5c11\u3002\u9274\u4e8e\u76ee\u524d\u5173\u4e8e\u96ea\u65fa\u7ec6\u80de\u79fb\u690d\u7684\u4e34\u5e8a\u7814\u7a76\u532e\u4e4f\uff0c\u672a\u6765\u9700\u8981\u5f00\u5c55\u66f4\u591a\u7814\u7a76\u6765\u8bc4\u4f30\u5176\u7597\u6548\u548c\u5b89\u5168\u6027\u3002<\/span><\/div>\n<div><\/div>\n<div class=\"u-margin-s-bottom\"><span dir=\"auto\">2017\u5e74\uff0cAnderson\u7b49\u4eba\u53d1\u8868\u4e86\u4e00\u9879I\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\uff0c\u8be5\u8bd5\u9a8c\u8bc4\u4f30\u4e86\u81ea\u4f53\u4eba\u96ea\u65fa\u7ec6\u80de\u79fb\u690d\u5230\u4e9a\u6025\u6027\u80f8\u6bb5\u5b8c\u5168\u6027\u810a\u9ad3\u635f\u4f24\uff08SCI\uff09\u60a3\u8005\u635f\u4f24\u4e2d\u5fc3\u90e8\u4f4d\u7684\u5b89\u5168\u6027\uff0c\u8bc1\u5b9e\u4e86\u5176\u5b89\u5168\u6027<\/span><span dir=\"auto\">\u30022022\u5e74\uff0cGrant\u7b49\u4eba\uff08\u540c\u4e00\u7814\u7a76\u56e2\u961f\u7684\u6210\u5458\uff09\u62a5\u544a\u4e86\u4e00\u9879\u9488\u5bf9\u6162\u6027SCI\u60a3\u8005\u7684\u7c7b\u4f3c\u7814\u7a76\uff08NCT02354625\uff09<\/span><span dir=\"auto\">\u3002\u4ed6\u4eec\u5c06\u79fb\u690d\u4e0e\u4f53\u80fd\u548c\u5eb7\u590d\u8bad\u7ec3\u76f8\u7ed3\u5408\uff0c\u65e8\u5728\u89e3\u51b3\u56e0\u8eab\u4f53\u5e9f\u7528\u5bfc\u81f4\u7684\u529f\u80fd\u8870\u9000\uff0c\u5e76\u523a\u6fc0\u534f\u8c03\u7684\u795e\u7ecf\u6d3b\u52a8\uff0c\u4ece\u800c\u589e\u5f3a\u795e\u7ecf\u53ef\u5851\u6027\uff0c\u8fd9\u5bf9\u4e8e\u4fc3\u8fdbSCI\u540e\u7684\u5eb7\u590d\u81f3\u5173\u91cd\u8981\u3002\u4e3a\u4e86\u907f\u514d\u79fb\u690d\u548c\u5eb7\u590d\u4e4b\u95f4\u7684\u6df7\u6742\u56e0\u7d20\uff0c\u6bcf\u4f4d\u53c2\u4e0e\u8005\u90fd\u5b9e\u65bd\u4e86\u6807\u51c6\u5316\u7684\u79fb\u690d\u524d\u540e\u8bad\u7ec3\u65b9\u6848\u3002\u8be5\u65b9\u6848\u672a\u53d1\u751f\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\uff08SAE\uff09\uff0c\u79fb\u690d\u540e6\u4e2a\u6708\u8fdb\u884c\u7684\u529f\u80fd\u8bc4\u4f30\u663e\u793a\uff0c\u90e8\u5206\u60a3\u8005\u7684\u611f\u89c9\u548c\u8fd0\u52a8\u529f\u80fd\u6709\u6240\u6539\u5584\u3002<\/span><\/div>\n<\/div>\n<div>\n<h2 id=\"sectitle0075\" class=\"u-h4 u-margin-l-top u-margin-xs-bottom\"><span class=\"ez-toc-section\" id=\"OEC\"><\/span><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\">OEC<\/span><\/span><\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<div id=\"p0295\" class=\"u-margin-s-bottom\"><span dir=\"auto\">\u4ece\u55c5\u9ecf\u819c\u5230\u55c5\u7403\u7684\u55c5\u89c9\u795e\u7ecf\u7cfb\u7edf\u662f\u4e00\u4e2a\u7279\u6b8a\u7684\u90e8\u4f4d\uff0c\u5728\u751f\u7406\u6761\u4ef6\u4e0b\uff0c\u795e\u7ecf\u548c\u8f74\u7a81\u53ef\u4ee5\u518d\u751f<\/span><span dir=\"auto\">\u3002\u8fd9\u79cd\u518d\u751f\u6548\u5e94\u88ab\u8ba4\u4e3a\u662f\u7531\u5b58\u5728\u4e8e\u55c5\u9ecf\u819c\u4e0a\u76ae\u4e2d\u7684\u795e\u7ecf\u5e72\u7ec6\u80de\u548c\u55c5\u9798\u7ec6\u80de\uff08OEC\uff09\u5f15\u8d77\u7684\u3002OEC\u5305\u88f9\u7740\u55c5\u89c9\u795e\u7ecf\u5143\u7684\u65e0\u9ad3\u9798\u8f74\u7a81\uff0c\u5176\u4f5c\u7528\u65b9\u5f0f\u4e0e\u96ea\u65fa\u7ec6\u80de\u5305\u88f9\u5468\u56f4\u795e\u7ecf\u5143\u7c7b\u4f3c\u3002\u56e0\u6b64\uff0c\u5728\u8fc7\u53bb\u7684\u4e8c\u5341\u5e74\u4e2d\uff0c\u5df2\u6709\u5173\u4e8e\u4f7f\u7528\u542b\u6709OEC\u7684\u55c5\u9ecf\u819c<\/span><span dir=\"auto\">\u548c\u55c5\u56fa\u6709\u5c42<\/span><span dir=\"auto\">\u8fdb\u884c\u4e34\u5e8a\u7814\u7a76\u7684\u62a5\u9053\u3002\u7531\u4e8e\u5355\u72ec\u79fb\u690d OEC \u65f6\u529f\u80fd\u6539\u5584\u6709\u9650<\/span><span dir=\"auto\">\uff0c\u8fd1\u5e74\u6765\u5df2\u5f00\u59cb\u5bf9 OEC \u4e0e MSC<\/span><span dir=\"auto\">\u6216\u96ea\u65fa\u7ec6\u80de<\/span><span class=\"anchor-text-container\"><span class=\"anchor-text\"><span dir=\"auto\">\u5171\u540c\u79fb\u690d\u7684\u4e34\u5e8a\u7814\u7a76\u3002<\/span><\/span><\/span><\/div>\n<div><\/div>\n<div class=\"u-margin-s-bottom\"><span dir=\"auto\">Chen\u7b49\u4eba\u5f00\u5c55\u4e86\u4e00\u9879\u968f\u673a\u53cc\u76f2\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u91c7\u7528\u55c5\u9798\u7ec6\u80de\uff08OECs\uff09\u548c\u96ea\u65fa\u7ec6\u80de\u8054\u5408\u6cbb\u7597\u6162\u6027\u5b8c\u5168\u6027\u9888\u690e\u810a\u9ad3\u635f\u4f24\uff08SCI\uff09\u60a3\u8005<\/span><span dir=\"auto\">\u3002\u4e03\u540d\u53d7\u8bd5\u8005\u88ab\u5206\u4e3a\u56db\u7ec4\uff1a\u4e09\u7ec4\u4ec5\u63a5\u53d7OECs\u79fb\u690d\uff0c\u4e00\u7ec4\u4ec5\u63a5\u53d7\u96ea\u65fa\u7ec6\u80de\u79fb\u690d\uff0c\u4e00\u7ec4\u540c\u65f6\u63a5\u53d7OECs\u548c\u96ea\u65fa\u7ec6\u80de\u79fb\u690d\uff0c\u4e24\u540d\u60a3\u8005\u4f5c\u4e3a\u5bf9\u7167\u7ec4\u672a\u63a5\u53d7\u4efb\u4f55\u79fb\u690d\u3002OECs\u548c\u96ea\u65fa\u7ec6\u80de\u5206\u522b\u6765\u6e90\u4e8e\u6d41\u4ea7\u7684\u4eba\u7c7b\u80ce\u513f\u55c5\u7403\u548c\u5750\u9aa8\u795e\u7ecf\u3002\u79fb\u690d\u65f6\uff0c\u6bcf\u4f4d\u60a3\u8005\u810a\u9ad3\u635f\u4f24\u4e2d\u5fc3\u4e0a\u65b9\u548c\u4e0b\u65b9\u5404\u6ce8\u5c04\u4e00\u767e\u4e07\u4e2a\u7ec6\u80de\u3002\u7ed3\u679c\u663e\u793a\uff0c\u79fb\u690d\u540e6\u4e2a\u6708\uff0c\u6cbb\u7597\u7ec4\u7684\u4e94\u540d\u53d7\u8bd5\u8005\u5747\u8868\u73b0\u51fa\u4e00\u5b9a\u7a0b\u5ea6\u7684\u795e\u7ecf\u529f\u80fd\u6539\u5584\uff0c\u800c\u5bf9\u7167\u7ec4\u672a\u89c2\u5bdf\u5230\u4efb\u4f55\u53d8\u5316\u3002\u7136\u800c\uff0c\u7edf\u8ba1\u5206\u6790\u663e\u793a\u6cbb\u7597\u7ec4\u548c\u5bf9\u7167\u7ec4\u4e4b\u95f4\u65e0\u663e\u8457\u5dee\u5f02\uff0c\u4f5c\u8005\u8ba4\u4e3a\u9700\u8981\u5f00\u5c55\u66f4\u5927\u6837\u672c\u91cf\u7684\u7814\u7a76\u3002<\/span><\/div>\n<div><\/div>\n<div class=\"u-margin-s-bottom\"><span dir=\"auto\">2021\u5e74\uff0cZamai\u7b49\u4eba\u53d1\u8868\u4e86\u4e00\u9879I\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\uff0c\u8be5\u8bd5\u9a8c\u5bf9\u4e09\u540d\u6162\u6027\u5b8c\u5168\u6027\u80f8\u6bb5\u810a\u9ad3\u635f\u4f24\u60a3\u8005\u8fdb\u884c\u4e86\u9798\u5185OEC\u548cMSC\u8054\u5408\u79fb\u690d<\/span><span dir=\"auto\">\u3002\u7ed3\u679c\u663e\u793a\uff0c\u5728\u4e3a\u671f\u4e24\u5e74\u7684\u968f\u8bbf\u671f\u95f4\uff0c\u672a\u89c2\u5bdf\u5230\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\u3002\u5176\u4e2d\u4e00\u540d\u60a3\u8005\u7684\u611f\u89c9\u8bc4\u5206\u548c\u810a\u9ad3\u72ec\u7acb\u6027\u8bc4\u5b9a\u91cf\u8868III\u8bc4\u5206\u6709\u6240\u6539\u5584\uff0c\u4f46\u6240\u6709\u60a3\u8005\u5747\u672a\u89c2\u5bdf\u5230\u8fd0\u52a8\u529f\u80fd\u6062\u590d\u3002<\/span><\/div>\n<div><\/div>\n<div class=\"u-margin-s-bottom\"><span dir=\"auto\">\u5173\u4e8eOEC\u79fb\u690d\u7684\u4e34\u5e8a\u7814\u7a76\u62a5\u9053\u8f83\u5c11\uff1b\u56e0\u6b64\uff0c\u671f\u5f85\u672a\u6765\u7684\u7814\u7a76\u6765\u8bc4\u4f30\u5176\u7597\u6548\u548c\u5b89\u5168\u6027\u3002<\/span><span class=\"anchor-text-container\"><span class=\"anchor-text\"><span dir=\"auto\">\u88683<\/span><\/span><\/span><span dir=\"auto\">\u603b\u7ed3\u4e86\u8fd1\u671f\u5173\u4e8e\u96ea\u65fa\u7ec6\u80de\u548cOEC\u7684\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c<\/span><span dir=\"auto\">The<\/span><\/div>\n<div><\/div>\n<\/div>\n<div>\n<div id=\"attachment_20526\" style=\"width: 2838px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-20526\" class=\"wp-image-20526 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5de5\u4f5c\u7c3f3_Sheet11.png\" alt=\"\" width=\"2828\" height=\"1508\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5de5\u4f5c\u7c3f3_Sheet11.png 2828w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5de5\u4f5c\u7c3f3_Sheet11-300x160.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5de5\u4f5c\u7c3f3_Sheet11-1024x546.png 1024w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5de5\u4f5c\u7c3f3_Sheet11-768x410.png 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5de5\u4f5c\u7c3f3_Sheet11-1536x819.png 1536w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5de5\u4f5c\u7c3f3_Sheet11-2048x1092.png 2048w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5de5\u4f5c\u7c3f3_Sheet11-18x10.png 18w\" sizes=\"(max-width: 2828px) 100vw, 2828px\" \/><p id=\"caption-attachment-20526\" class=\"wp-caption-text\">\u8868 3.\u8fd1\u671f\u6d89\u53ca\u96ea\u65fa\u7ec6\u80de\u548c OEC \u6cbb\u7597\u810a\u9ad3\u635f\u4f24\u7684\u4e3b\u8981\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/p><\/div>\n<p>&nbsp;<\/p>\n<div class=\"groups\"><\/div>\n<\/div>\n<h2><span class=\"ez-toc-section\" id=\"%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E4%BA%BA%E7%B1%BB%E8%84%8A%E9%AB%93%E6%8D%9F%E4%BC%A4%EF%BC%9A%E8%BF%91%E6%9C%9F%E4%B8%B4%E5%BA%8A%E7%A0%94%E7%A9%B6%E7%BB%BC%E8%BF%B0%E7%9A%84%E8%AE%A8%E8%AE%BA%E4%B8%8E%E7%BB%93%E8%AE%BA\"><\/span>\u5e72\u7ec6\u80de\u6cbb\u7597\u4eba\u7c7b\u810a\u9ad3\u635f\u4f24\uff1a\u8fd1\u671f\u4e34\u5e8a\u7814\u7a76\u7efc\u8ff0\u7684\u8ba8\u8bba\u4e0e\u7ed3\u8bba<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<h3><span class=\"ez-toc-section\" id=\"1_%E5%B9%B2%E7%BB%86%E8%83%9E%E7%96%97%E6%B3%95%E7%96%97%E6%95%88%E4%B8%8D%E4%BD%B3%E7%9A%84%E5%A4%9A%E9%87%8D%E6%8C%91%E6%88%98\"><\/span>1.\u00a0<strong>\u5e72\u7ec6\u80de\u7597\u6cd5\u7597\u6548\u4e0d\u4f73\u7684\u591a\u91cd\u6311\u6218<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p data-spm-anchor-id=\"5176.28103460.0.i9.51d07551FH8sxE\">\u5e72\u7ec6\u80de\u7597\u6cd5\u5e94\u7528\u4e8e\u810a\u9ad3\u635f\u4f24\uff08SCI\uff09\u4e34\u5e8a\u6cbb\u7597\u5df2\u903e\u5341\u5e74\uff0c\u4f46\u5c1a\u672a\u5b9e\u73b0\u663e\u8457\u7597\u6548\u7a81\u7834\u3002\u8fd9\u4e00\u56f0\u5883\u6e90\u4e8e\u591a\u56e0\u7d20\u7684\u590d\u6742\u6027\uff1a\u635f\u4f24\u90e8\u4f4d\uff08\u9888\u690e\u6216\u80f8\u690e\uff09\u3001\u53d7\u4f24\u65f6\u95f4\uff08\u6025\u6027\/\u6162\u6027\u671f\uff09\u3001\u60a3\u8005\u57fa\u7ebf\u529f\u80fd\u72b6\u6001\u3001\u5e76\u53d1\u75c7\uff08\u5982\u547c\u5438\u7cfb\u7edf\u75be\u75c5\uff09\u53ca\u5eb7\u590d\u5e72\u9884\u5f3a\u5ea6\u5747\u9700\u7efc\u5408\u8003\u91cf\u3002\u6b64\u5916\uff0c\u4e34\u5e8a\u8bd5\u9a8c\u62db\u52df\u96be\u5ea6\u5927\uff0c\u56e0\u60a3\u8005\u533b\u7597\u8d1f\u62c5\u91cd\u4e14\u9700\u957f\u671f\u968f\u8bbf\u3002\u5c3d\u7ba1\u591a\u6570SCI\u60a3\u8005\u4e3a\u9888\u690e\u635f\u4f24\uff0c\u4f46\u80f8\u690eSCI\u5e38\u88ab\u4f18\u5148\u9009\u62e9\uff0c\u56e0\u5176\u98ce\u9669\u8f83\u4f4e\uff0c\u800c\u9888\u690e\u635f\u4f24\u60a3\u8005\u56e0\u8f7b\u5fae\u529f\u80fd\u6076\u5316\u53ef\u80fd\u5371\u53ca\u751f\u547d\uff0c\u5bfc\u81f4\u4e34\u5e8a\u8bd5\u9a8c\u7eb3\u5165\u7387\u53d7\u9650\u3002\u80f8\u690e\u8282\u6bb5\u7f3a\u4e4f\u8282\u6bb5\u6027\u8fd0\u52a8\u795e\u7ecf\uff0c\u529f\u80fd\u6539\u5584\u8bc4\u4f30\u672c\u8eab\u5b58\u5728\u6311\u6218\uff0c\u8fdb\u4e00\u6b65\u963b\u788d\u7597\u6548\u9a8c\u8bc1\u3002<\/p>\n<hr \/>\n<h3><span class=\"ez-toc-section\" id=\"2_%E7%BB%86%E8%83%9E%E7%A7%BB%E6%A4%8D%E9%80%94%E5%BE%84%E7%9A%84%E6%8A%80%E6%9C%AF%E6%9D%83%E8%A1%A1\"><\/span>2.\u00a0<strong>\u7ec6\u80de\u79fb\u690d\u9014\u5f84\u7684\u6280\u672f\u6743\u8861<\/strong><span 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