{"id":20541,"date":"2025-11-18T18:55:44","date_gmt":"2025-11-18T10:55:44","guid":{"rendered":"https:\/\/www.hjtdsm.cn\/?p=20541"},"modified":"2025-11-18T18:56:14","modified_gmt":"2025-11-18T10:56:14","slug":"https-www-hjtdsm-cn-stem-cells-mscs-20541-html","status":"publish","type":"post","link":"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/mscs\/20541.html","title":{"rendered":"\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6cbb\u7597\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\u83b7\u957f\u671f\u7597\u6548\uff1a\u5355\u7528\u4e0e\u8054\u7528IFN-\u03b3\u5747\u663e\u793a\u4e94\u5e74\u6301\u7eed\u6709\u6548\u6027"},"content":{"rendered":"<blockquote><p>\u4e3a\u4e86\u62a5\u544a\u95f4\u5145\u8d28\u5e72\u7ec6\u80de (MSC) \u4e0e IFN-\u03b3 \u8054\u5408\u6216\u4e0d\u8054\u5408\u6cbb\u7597\u7c7b\u98ce\u6e7f\u6027\u5173\u8282\u708e (RA) \u60a3\u8005\u7684\u957f\u671f\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\uff0c\u4f7f\u7528\u4e86\u6765\u81ea\u4e24\u9879\u5173\u4e8e\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6cbb\u7597\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\u7684\u968f\u673a\u4e34\u5e8a\u8bd5\u9a8c\u4ee5\u53ca\u540e\u7eed\u957f\u671f\u6269\u5c55 (LTE) \u7814\u7a76\u7684\u6c47\u603b\u6570\u636e\u3002<\/p><\/blockquote>\n<p>\u8fd1\u65e5\uff0c\u4e2d\u56fd\u91cd\u5e86\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u7b2c\u4e00\u533b\u9662\u98ce\u6e7f\u514d\u75ab\u79d1\u3001\u514d\u75ab\u8870\u8001\u4e0e\u518d\u751f\u4e2d\u5fc3\u8054\u5408\u4e2d\u56fd\u91cd\u5e86\u5e02\u9646\u519b\u519b\u533b\u5927\u5b66\u5927\u576a\u533b\u9662\u521b\u4f24\u4e0e\u5316\u5b66\u4e2d\u6bd2\u56fd\u5bb6\u91cd\u70b9\u5b9e\u9a8c\u5ba4\u5e72\u7ec6\u80de\u4e0e\u518d\u751f\u533b\u5b66\u79d1\u5728\u671f\u520a\u6742\u5fd7\u300aStem Cell Research &amp; Therapy\u300b\u4e0a\u53d1\u8868\u4e86\u4e00\u9879<a href=\"https:\/\/link.springer.com\/article\/10.1186\/s13287-025-04772-x\" target=\"_blank\" rel=\"noopener nofollow\">\u201c\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u8054\u5408\u5e72\u6270\u7d20-\u03b3\u6cbb\u7597\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\u4e0e\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u5355\u836f\u6cbb\u7597\u7684\u6bd4\u8f83\uff1a\u4e94\u5e74\u671f\u5ef6\u957f\u968f\u8bbf\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u8bc4\u4f30\u201d<\/a>\u7684\u7814\u7a76\u7efc\u8ff0\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-20546 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-18_175645_787.png\" alt=\"\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6cbb\u7597\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\u83b7\u957f\u671f\u7597\u6548\uff1a\u5355\u7528\u4e0e\u8054\u7528IFN-\u03b3\u5747\u663e\u793a\u4e94\u5e74\u6301\u7eed\u6709\u6548\u6027\" width=\"706\" height=\"434\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-18_175645_787.png 706w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-18_175645_787-300x184.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-18_175645_787-18x12.png 18w\" sizes=\"(max-width: 706px) 100vw, 706px\" \/><\/p>\n<p>\u7efc\u8ff0\u8868\u660e\uff1a<strong>\u4e24\u98791\/2\u671f\u968f\u673a\u4e34\u5e8a\u8bd5\u9a8c\u8868\u660e\uff0c\u5bf9\u4e8e\u5e38\u89c4\u6cbb\u7597\uff08\u5305\u62eccsDMARDs\u3001NSAIDs\u3001bDMARDs\u548c\u7c7b\u56fa\u9187\uff09\u5e94\u7b54\u4e0d\u8db3\u6216\u8010\u53d7\u4e0d\u826f\u7684\u6d3b\u52a8\u6027\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\u6210\u5e74\u60a3\u8005\uff0c\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09\u663e\u793a\u51fa\u663e\u8457\u7597\u6548\u3002\u672c\u6b21\u957f\u671f\u6269\u5c55\u7814\u7a76\u8bc1\u5b9e\uff0c\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u5355\u836f\u6cbb\u7597\u5177\u6709\u6301\u7eed\u826f\u597d\u7684\u5b89\u5168\u6027\u4e0e\u7597\u6548\u7279\u5f81\uff0c\u800c\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u8054\u5408\u03b3-\u5e72\u6270\u7d20\uff08IFN-\u03b3\uff09\u7684\u6cbb\u7597\u7b56\u7565\u53ef\u663e\u8457\u63d0\u5347\u57fa\u4e8eMSCs\u7684\u7597\u6cd5\u5bf9\u6d3b\u52a8\u6027\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\u7684\u4e34\u5e8a\u7597\u6548<\/strong>The<\/p>\n<p class=\"ds-markdown-paragraph\">\u5bf9\u4e8e\u5e38\u89c4\u6cbb\u7597\u5e94\u7b54\u4e0d\u8db3\u6216\u8010\u53d7\u4e0d\u826f\u7684\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\u60a3\u8005\uff0c\u57fa\u4e8eMSCs\u7684\u7ec6\u80de\u7597\u6cd5\u662f\u4e00\u79cd\u65b0\u578b\u6cbb\u7597\u9009\u62e9\u3002\u5176\u957f\u671f\u5b89\u5168\u6027\u548c\u7597\u6548\u4f18\u52bf\u6e90\u4e8eMSCs\u4ecb\u5bfc\u7684\u514d\u75ab\u8c03\u8282\u4f5c\u7528\uff0c\u8fd9\u4e00\u673a\u5236\u5e94\u5728\u672a\u6765\u4e34\u5e8a\u7ba1\u7406\u4e2d\u4e88\u4ee5\u5145\u5206\u8003\u8651\u3002<\/p>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_79_2 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewbox=\"0 0 24 24\" version=\"1.2\" baseprofile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/mscs\/20541.html\/#%E8%83%8C%E6%99%AF\" >\u80cc\u666f<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/mscs\/20541.html\/#%E9%AA%8C%E8%AF%81%E9%97%B4%E5%85%85%E8%B4%A8%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E7%B1%BB%E9%A3%8E%E6%B9%BF%E5%85%B3%E8%8A%82%E7%82%8E%E6%9C%89%E6%95%88%E6%80%A7%E7%9A%84%E6%96%B9%E6%B3%95\" >\u9a8c\u8bc1\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6cbb\u7597\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\u6709\u6548\u6027\u7684\u65b9\u6cd5<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/mscs\/20541.html\/#%E9%97%B4%E5%85%85%E8%B4%A8%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E7%B1%BB%E9%A3%8E%E6%B9%BF%E5%85%B3%E8%8A%82%E7%82%8E%E5%AE%89%E5%85%A8%E6%80%A7%E5%92%8C%E6%9C%89%E6%95%88%E6%80%A7%E7%9A%84%E7%BB%93%E6%9E%9C\" >\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6cbb\u7597\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u7684\u7ed3\u679c<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/mscs\/20541.html\/#%E6%82%A3%E8%80%85%E5%AE%89%E6%8E%92\" >\u60a3\u8005\u5b89\u6392<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/mscs\/20541.html\/#%E9%97%B4%E5%85%85%E8%B4%A8%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E7%B1%BB%E9%A3%8E%E6%B9%BF%E5%85%B3%E8%8A%82%E7%82%8E%E7%9A%84%E5%AE%89%E5%85%A8%E6%80%A7\" >\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6cbb\u7597\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\u7684\u5b89\u5168\u6027<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/mscs\/20541.html\/#%E9%97%B4%E5%85%85%E8%B4%A8%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E7%B1%BB%E9%A3%8E%E6%B9%BF%E5%85%B3%E8%8A%82%E7%82%8E%E7%9A%84%E4%B8%B4%E5%BA%8A%E7%96%97%E6%95%88\" >\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6cbb\u7597\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\u7684\u4e34\u5e8a\u7597\u6548<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/mscs\/20541.html\/#%E7%96%BE%E7%97%85%E6%B4%BB%E5%8A%A8%E6%80%A7\" >\u75be\u75c5\u6d3b\u52a8\u6027<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/mscs\/20541.html\/#%E7%94%A8%E8%8D%AF%E6%96%B9%E6%A1%88\" >\u7528\u836f\u65b9\u6848<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/mscs\/20541.html\/#%E8%AE%A8%E8%AE%BA%EF%BC%9A%E9%97%B4%E5%85%85%E8%B4%A8%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E7%B1%BB%E9%A3%8E%E6%B9%BF%E5%85%B3%E8%8A%82%E7%82%8E%E7%9A%84%E7%BB%93%E6%9E%9C\" >\u8ba8\u8bba\uff1a\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6cbb\u7597\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\u7684\u7ed3\u679c<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/mscs\/20541.html\/#%E6%9C%80%E7%BB%88%E7%BB%93%E8%AE%BA\" >\u6700\u7ec8\u7ed3\u8bba<\/a><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"%E8%83%8C%E6%99%AF\"><\/span>\u80cc\u666f<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span dir=\"auto\">\u5c3d\u7ba1\u7c7b\u98ce\u6e7f\u6027\u5173\u8282\u708e\uff08RA\uff09\u7684\u53d1\u75c5\u673a\u5236\u5c1a\u672a\u5b8c\u5168\u9610\u660e\uff0c\u4f46\u6700\u65b0\u7814\u7a76\u8868\u660e\uff0c\u591a\u79cd\u4fc3\u708e\u7ec6\u80de\u56e0\u5b50\u548c\u514d\u75ab\u7ec6\u80de\u5728\u5176\u53d1\u751f\u53d1\u5c55\u4e2d\u53d1\u6325\u7740\u91cd\u8981\u4f5c\u7528<\/span><span dir=\"auto\">\u3002\u5c3d\u7ba1RA\u6cbb\u7597\u836f\u7269\u53d6\u5f97\u4e86\u5de8\u5927\u7684\u533b\u5b66\u8fdb\u6b65\uff0c\u4f46\u53ea\u6709\u5c11\u6570\u60a3\u8005\u80fd\u591f\u5b9e\u73b0\u75be\u75c5\u7f13\u89e3\uff0c\u5e76\u5728\u505c\u836f\u540e\u4fdd\u6301\u6301\u7eed\u7f13\u89e3<\/span><span dir=\"auto\">The<\/span><\/p>\n<p><span dir=\"auto\">\u5927\u91cf\u4e34\u5e8a\u7814\u7a76\u5df2\u91c7\u7528\u5f02\u4f53<a href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/mscs\/20023.html\/\" target=\"_blank\" rel=\"noopener\">\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09<\/a>\u6cbb\u7597\u591a\u79cd\u4e34\u5e8a\u75be\u75c5\uff0c\u8fd9\u4e9b\u7ec6\u80de\u4e3b\u8981\u6765\u6e90\u4e8e<a href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/mscs\/19975.html\/\" target=\"_blank\" rel=\"noopener\">\u6210\u4eba\u9aa8\u9ad3\u3001\u8102\u80aa\u7ec4\u7ec7\u6216\u8110\u5e26\uff08UC\uff09<\/a><\/span><span dir=\"auto\">\u3002MSCs\u72ec\u7279\u7684\u6297\u708e\u548c\u514d\u75ab\u6291\u5236\u7279\u6027\u4f7f\u5176\u5728\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u4e2d\u5f97\u5230\u5e7f\u6cdb\u5e94\u7528\uff0c\u5e76\u56e0\u5176\u7597\u6548\u548c\u77ed\u671f\u5b89\u5168\u6027\u800c\u83b7\u5f97\u5e7f\u6cdb\u8ba4\u53ef<\/span><span dir=\"auto\">\u3002\u8fc7\u53bb\u5341\u5e74\uff0cMSCs\u79fb\u690d\uff08MSCT\uff09\u5df2\u5c1d\u8bd5\u7528\u4e8e\u6cbb\u7597\u7cfb\u7edf\u6027\u7ea2\u6591\u72fc\u75ae\u3001\u5e72\u71e5\u7efc\u5408\u5f81\u3001\u7cfb\u7edf\u6027\u786c\u5316\u75c7\u3001\u79fb\u690d\u7269\u6297\u5bbf\u4e3b\u75c5\u548c\u76ae\u808c\u708e\/\u591a\u53d1\u6027\u808c\u708e\uff0c\u5e76\u663e\u793a\u51fa\u4ee4\u4eba\u6ee1\u610f\u7684\u4e34\u5e8a\u5b89\u5168\u6027<\/span><span dir=\"auto\">\u3002\u7406\u8bba\u4e0a\uff0cMSCT\u540e\u7684\u957f\u671f\u5f71\u54cd\u53ef\u80fd\u5305\u62ec\u6f5c\u5728\u7684\u514d\u75ab\u6291\u5236\u3001\u611f\u67d3\u548c\u80bf\u7624\u53d1\u751f\u3002\u7136\u800c\uff0c\u8fc4\u4eca\u4e3a\u6b62\uff0c\u8fd8\u6ca1\u6709\u5173\u4e8eMSCT\u6cbb\u7597\u7c7b\u98ce\u6e7f\u6027\u5173\u8282\u708e\u60a3\u8005\u7684\u957f\u671f\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u7684\u62a5\u9053\u3002<\/span><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-20547 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/istockphoto-1289026009-612x612-1.jpg\" alt=\"\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6cbb\u7597\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\u83b7\u957f\u671f\u7597\u6548\uff1a\u5355\u7528\u4e0e\u8054\u7528IFN-\u03b3\u5747\u663e\u793a\u4e94\u5e74\u6301\u7eed\u6709\u6548\u6027\" width=\"612\" height=\"376\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/istockphoto-1289026009-612x612-1.jpg 612w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/istockphoto-1289026009-612x612-1-300x184.jpg 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/istockphoto-1289026009-612x612-1-18x12.jpg 18w\" sizes=\"(max-width: 612px) 100vw, 612px\" \/><\/p>\n<p><span dir=\"auto\">\u5728\u672c\u7814\u7a76\u4e2d\uff0c\u4e24\u9879\u4e3a\u671f48\u5468\u7684I\/II\u671f\u968f\u673a\u3001\u53cc\u76f2\u4e34\u5e8a\u8bd5\u9a8c\u5206\u522b\u8bc4\u4f30\u4e86\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09\u5355\u836f\u6cbb\u7597\u548cMSCs\u8054\u5408\u5e72\u6270\u7d20-\u03b3\uff08IFN-\u03b3\uff09\u6cbb\u7597\u7684\u6548\u679c\u3002\u7ed3\u679c\u663e\u793a\uff0cMSCs\u663e\u8457\u6539\u5584\u4e86\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\uff08RA\uff09\u7684\u4f53\u5f81\u548c\u75c7\u72b6\uff0c\u5bf9\u4e8e\u4e2d\u91cd\u5ea6\u6d3b\u52a8\u6027RA\u60a3\u8005\uff0c\u5c24\u5176\u662f\u90a3\u4e9b\u5bf9\u5305\u62ec\u4f20\u7edf\u5408\u6210\u75be\u75c5\u4fee\u9970\u6297\u98ce\u6e7f\u836f\uff08csDMARDs\uff09\u3001\u975e\u753e\u4f53\u7c7b\u6297\u708e\u836f\uff08NSAIDs\uff09\u3001\u751f\u7269\u5236\u5242DMARDs\uff08bDMARDs\uff09\u548c\u7cd6\u76ae\u8d28\u6fc0\u7d20\u5728\u5185\u7684\u5e38\u89c4\u4e34\u5e8a\u6cbb\u7597\u53cd\u5e94\u4e0d\u4f73\u6216\u65e0\u6cd5\u8010\u53d7\u8fd9\u4e9b\u836f\u7269\u4e25\u91cd\u526f\u4f5c\u7528\u7684\u60a3\u8005\uff0cMSCs\u80fd\u591f\u6539\u5584\u5176\u8eab\u4f53\u673a\u80fd\u548c\u5065\u5eb7\u72b6\u51b5\uff08ChiCTR-ONC-16008770\u548cChiCTR-INR-17012462\uff09\u3002\u6b64\u5916\uff0cMSCs\u8054\u5408IFN-\u03b3\u6cbb\u7597\u7684\u7597\u6548\u4f18\u4e8eMSCs\u5355\u836f\u6cbb\u7597<\/span><span dir=\"auto\">The<\/span><\/p>\n<p><span dir=\"auto\">\u53c2\u4e0e\u6838\u5fc3\u53cc\u76f2\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\uff08RCT\uff09\u7684\u60a3\u8005\u5728\u7b7e\u7f72\u77e5\u60c5\u540c\u610f\u4e66\uff08ICF\uff09\u540e\uff0c\u53ef\u53c2\u4e0e\u540e\u7eed\u7684\u957f\u671f\u6269\u5c55\uff08LTE\uff09\u7814\u7a76\u3002\u672c\u62a5\u544a\u6c47\u603b\u4e86\u6765\u81ea\u540c\u4e00\u4e2d\u5fc3\u4e24\u98791\/2\u671f\u7814\u7a76\u7684\u957f\u671f\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSC\uff09\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u6570\u636e\uff0c\u4e3a\u672a\u6765\u7684\u4e34\u5e8a\u5b9e\u8df5\u63d0\u4f9b\u4e86\u91cd\u8981\u4fe1\u606f\u3002<\/span><\/p>\n<h2 id=\"Sec2\" class=\"c-article-section__title js-section-title js-c-reading-companion-sections-item\"><span class=\"ez-toc-section\" id=\"%E9%AA%8C%E8%AF%81%E9%97%B4%E5%85%85%E8%B4%A8%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E7%B1%BB%E9%A3%8E%E6%B9%BF%E5%85%B3%E8%8A%82%E7%82%8E%E6%9C%89%E6%95%88%E6%80%A7%E7%9A%84%E6%96%B9%E6%B3%95\"><\/span><span dir=\"auto\">\u9a8c\u8bc1\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6cbb\u7597\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\u6709\u6548\u6027\u7684\u65b9\u6cd5<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<div id=\"Sec2-content\" class=\"c-article-section__content\">\n<p id=\"Sec3\" class=\"c-article__sub-heading\"><strong><span dir=\"auto\">\u60a3\u8005\u7fa4\u4f53\uff1a<\/span><\/strong><span dir=\"auto\">\u6838\u5fc3\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\u7eb3\u5165\u4e86\u5bf9\u4f20\u7edf\u6cbb\u7597\uff08\u5305\u62ec\u4f20\u7edf\u5408\u6210DMARDs\u3001\u975e\u753e\u4f53\u6297\u708e\u836f\u3001\u751f\u7269\u5236\u5242DMARDs\u548c\u7cd6\u76ae\u8d28\u6fc0\u7d20\uff09\u53cd\u5e94\u4e0d\u8db3\u6216\u4e0d\u8010\u53d7\u7684\u6d3b\u52a8\u6027\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\uff08RA\uff09\u6210\u4eba\u60a3\u8005\u3002\u5b8c\u621048\u5468\u968f\u8bbf\u671f\u7684\u60a3\u8005\u7b26\u5408\u6761\u4ef6\uff0c\u53ef\u7ee7\u7eed\u53c2\u4e0e\u957f\u671f\u6269\u5c55\uff08LTE\uff09\u7814\u7a76\u3002\u6838\u5fc3\u7814\u7a76\u7684\u8be6\u7ec6\u7eb3\u5165\u548c\u6392\u9664\u6807\u51c6\u5df2\u5728\u5148\u524d\u53d1\u8868\u7684\u6587\u732e\u4e2d\u9610\u8ff0<\/span><span dir=\"auto\">The<\/span><\/p>\n<p id=\"Sec4\" class=\"c-article__sub-heading\"><strong><span dir=\"auto\">\u7814\u7a76\u8bbe\u8ba1\uff1a<\/span><\/strong><span dir=\"auto\">\u5728\u6838\u5fc3\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\uff08RCT\uff09\u4e2d\uff0c\u5bf9\u5e38\u89c4\u6cbb\u7597\u53cd\u5e94\u4e0d\u8db3\u7684\u60a3\u8005\u6839\u636e\u5177\u4f53\u7814\u7a76\u88ab\u968f\u673a\u5206\u914d\u63a5\u53d7\u5355\u6b21\u9759\u8109\u6ce8\u5c04\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff0c1 \u00d7 10\u2076\u4e2a\u7ec6\u80de\/kg\uff09\u6216 MSCs\uff081\u00d710\u2076\u4e2a\u7ec6\u80de\/kg\uff09\u8054\u5408\u808c\u6ce8\u5e72\u6270\u7d20-\u03b3\uff08IFN-\u03b3\uff0c100 \u4e07 IU\uff09\u3002\u6240\u6709\u53d7\u8bd5\u8005\u7684 MSCs \u6765\u6e90\u548c\u5236\u5907\u65b9\u6cd5\u5747\u4e00\u81f4\uff0c\u5747\u6765\u81ea\u540c\u4e00\u4f9b\u4f53\uff0c\u6b64\u524d\u5df2\u6709\u63cf\u8ff0<\/span><span dir=\"auto\">\u3002\u5b8c\u6210\u6838\u5fc3RCT \u5e76\u540c\u610f\u53c2\u4e0e\u957f\u671f\u6269\u5c55\u7814\u7a76\uff08LTE\uff09\u7684\u60a3\u8005\u5747\u63a5\u53d7\u6807\u51c6\u5316\u7684\u836f\u7269\u51cf\u91cf\u65b9\u6848\u3002\u51cf\u91cf\u65b9\u6848\u9075\u5faa\u6211\u4eec\u5df2\u53d1\u8868\u7684\u6807\u51c6<\/span><span dir=\"auto\">\uff0c\u8981\u6c42\u5728\u6bcf\u4e2a\u51cf\u91cf\u6b65\u9aa4\u5f00\u59cb\u524d\u81f3\u5c1112\u5468DAS28\u8bc4\u5206&lt;3.2\u3002\u5982\u679c\u53d7\u8bd5\u8005\u7684\u75c5\u60c5\u6301\u7eed\u6539\u5584\uff0c\u5219\u91c7\u7528\u505c\u836f\u65b9\u6848\uff0c\u6309\u4ee5\u4e0b\u987a\u5e8f\u9010\u6b65\u505c\u7528\u5e38\u89c4\u836f\u7269\u6cbb\u7597\uff1a\u7cd6\u76ae\u8d28\u6fc0\u7d20\u3001\u975e\u753e\u4f53\u6297\u708e\u836f\uff08NSAIDs\uff09\u548c\u6539\u5584\u75c5\u60c5\u6297\u98ce\u6e7f\u836f\uff08DMARDs\uff09\u3002\u6240\u6709\u6cbb\u7597\u65b9\u6848\u7684\u8c03\u6574\u5747\u5df2\u83b7\u5f97\u4e3b\u7ba1\u98ce\u6e7f\u75c5\u4e13\u5bb6\u7684\u6279\u51c6\u3002\u6838\u5fc3\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\u7684\u7814\u7a76\u8bbe\u8ba1\u8be6\u60c5\u89c1\u8865\u5145\u6750\u6599\u3002<\/span><\/p>\n<p id=\"Sec5\" class=\"c-article__sub-heading\"><strong><span dir=\"auto\">\u5b89\u5168\u8bc4\u4f30\uff1a<\/span><\/strong><span dir=\"auto\">\u5b89\u5168\u6027\u8bc4\u4f30\u5305\u62ec\u4e0d\u826f\u4e8b\u4ef6 (AE) \u548c\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6 (SAE)\uff0c\u4f7f\u7528\u533b\u5b66\u672f\u8bed\u96c6 (MedDRA) 27.1 \u7248\u8fdb\u884c\u7f16\u7801\uff0c\u4ee5\u53ca\u5728\u6574\u4e2a\u7814\u7a76\u671f\u95f4\u76d1\u6d4b\u7684\u5b9e\u9a8c\u5ba4\u68c0\u67e5\u3001\u751f\u547d\u4f53\u5f81\u3001\u4f53\u683c\u68c0\u67e5\u548c\u5176\u4ed6\u4e34\u5e8a\u76f8\u5173\u53c2\u6570\u3002<\/span><\/p>\n<p id=\"Sec6\" class=\"c-article__sub-heading\"><strong><span dir=\"auto\">\u4e34\u5e8a\u53cd\u5e94\uff1a<\/span><\/strong><span dir=\"auto\">\u7597\u6548\u8bc4\u4f30\u6307\u6807\u5305\u62ec\u75be\u75c5\u6d3b\u52a8\u5ea6\u8bc4\u520628 (DAS28) &lt; 2.6\uff08\u8868\u793a\u7f13\u89e3\uff09\u548c \u2264 3.2\uff08\u8868\u793a\u4f4e\u75be\u75c5\u6d3b\u52a8\u5ea6\uff09<\/span><span dir=\"auto\">\u3001\u7f8e\u56fd\u98ce\u6e7f\u75c5\u5b66\u4f1a (ACR) 20\/50\/70 \u8bc4\u5206<\/span><span dir=\"auto\">\u4ee5\u53ca\u5065\u5eb7\u8bc4\u4f30\u95ee\u5377-\u6b8b\u75be\u6307\u6570 (HAQ-DI)\u3002\u8fd9\u4e9b\u8bc4\u4f30\u5747\u6309\u7167\u6b27\u6d32\u98ce\u6e7f\u75c5\u534f\u4f1a\u8054\u76df (EULAR) \u5173\u4e8e\u98ce\u6e7f\u75c5\u4e34\u5e8a\u8bd5\u9a8c\u6269\u5c55\u7814\u7a76\u62a5\u544a\u7684\u5efa\u8bae\u8fdb\u884c<\/span><span dir=\"auto\">The<\/span><\/p>\n<p id=\"Sec7\" class=\"c-article__sub-heading\"><strong><span dir=\"auto\">\u7edf\u8ba1\u5206\u6790\uff1a<\/span><\/strong><span dir=\"auto\">\u5b89\u5168\u6027\u5206\u6790\u4eba\u7fa4\u5305\u62ec\u6240\u6709\u63a5\u53d7\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09\u79fb\u690d\u7684\u53d7\u8bd5\u8005\u3002\u60a3\u8005\u6309\u6cbb\u7597\u7ec4\u8fdb\u884c\u5206\u6790\uff1a\uff081\uff09MSCs\u5355\u836f\u6cbb\u7597\u7ec4\u548c\uff082\uff09MSCs\u8054\u5408\u5e72\u6270\u7d20-\u03b3\uff08IFN-\u03b3\uff09\u6cbb\u7597\u7ec4\u3002\u57fa\u7ebf\u5b89\u5168\u6027\u53d8\u91cf\u5b9a\u4e49\u4e3aMSCs\u79fb\u690d\u524d\u8bb0\u5f55\u7684\u6700\u65b0\u503c\u3002\u4e0d\u826f\u4e8b\u4ef6\uff08AEs\uff09\u4ee5\u4e8b\u4ef6\u603b\u6570\u548c\u66b4\u9732\u8c03\u6574\u540e\u7684\u4e8b\u4ef6\u53d1\u751f\u7387\uff08ERs\uff09\u8fdb\u884c\u6c47\u603b\uff0cERs\u7684\u8ba1\u7b97\u65b9\u6cd5\u4e3a\u6bcf100\u60a3\u8005\u5e74\uff08PYs\uff09\u89c2\u5bdf\u671f\u95f4\u7684\u4e8b\u4ef6\u6570\u3002\u603b\u89c2\u5bdf\u671f\u5b9a\u4e49\u4e3a\u4eceMSCs\u79fb\u690d\u5230\u6700\u540e\u4e00\u6b21\u8bb0\u5f55\u7684\u5b89\u5168\u6027\u8bc4\u4f30\u7684\u65f6\u95f4\u3002<\/span><\/p>\n<p><span dir=\"auto\">\u5bf9\u6240\u6709\u63a5\u53d7\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u79fb\u690d\u4e14\u5b8c\u6210\u22655\u5e74\u968f\u8bbf\u7684\u968f\u673a\u53d7\u8bd5\u8005\u8fdb\u884c\u4e86\u7597\u6548\u8bc4\u4f30\uff08\u56fe1<\/span><span dir=\"auto\">\uff09\u3002\u4e2d\u9014\u9000\u51fa\u7814\u7a76\u6216\u672a\u8fdb\u5165\u957f\u671f\u6269\u5c55\u7814\u7a76\u9636\u6bb5\u7684\u60a3\u8005\u88ab\u5f52\u7c7b\u4e3a\u65e0\u5e94\u7b54\u8005\uff0c\u800c\u5b8c\u6210\u8005\u5206\u6790\u4ec5\u5305\u62ec\u5728\u5206\u6790\u65f6\u95f4\u70b9\u6709\u53ef\u7528\u6570\u636e\u7684\u60a3\u8005\u3002<\/span><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-20545 aligncenter\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5fae\u4fe1\u56fe\u7247_2025-11-18_175823_893.png\" alt=\"\" width=\"685\" height=\"553\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5fae\u4fe1\u56fe\u7247_2025-11-18_175823_893.png 685w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5fae\u4fe1\u56fe\u7247_2025-11-18_175823_893-300x242.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5fae\u4fe1\u56fe\u7247_2025-11-18_175823_893-15x12.png 15w\" sizes=\"(max-width: 685px) 100vw, 685px\" \/><\/p>\n<h2 id=\"Sec8\" class=\"c-article-section__title js-section-title js-c-reading-companion-sections-item\"><span class=\"ez-toc-section\" id=\"%E9%97%B4%E5%85%85%E8%B4%A8%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E7%B1%BB%E9%A3%8E%E6%B9%BF%E5%85%B3%E8%8A%82%E7%82%8E%E5%AE%89%E5%85%A8%E6%80%A7%E5%92%8C%E6%9C%89%E6%95%88%E6%80%A7%E7%9A%84%E7%BB%93%E6%9E%9C\"><\/span><span dir=\"auto\">\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6cbb\u7597\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u7684\u7ed3\u679c<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<div id=\"Sec8-content\" class=\"c-article-section__content\">\n<h3 id=\"Sec9\" class=\"c-article__sub-heading\"><span class=\"ez-toc-section\" id=\"%E6%82%A3%E8%80%85%E5%AE%89%E6%8E%92\"><\/span><span dir=\"auto\">\u60a3\u8005\u5b89\u6392<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span dir=\"auto\">\u5171\u6709110\u4f8b\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\uff08RA\uff09\u60a3\u8005\u88ab\u968f\u673a\u5206\u914d\u81f3\u6838\u5fc3\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\uff08RCT\uff09\u5e76\u7eb3\u5165\u957f\u671f\u6269\u5c55\u7814\u7a76\uff08LTE\uff09\uff0c\u5176\u4e2d97\u4f8b\uff0888.2%\uff09\u5b8c\u6210\u4e86\u4e3a\u671f\u4e94\u5e74\u7684LTE\u7814\u7a76\uff08\u56fe1<\/span><span dir=\"auto\">\uff09\u3002\u603b\u4f53\u800c\u8a00\uff0c13\u4f8b\uff08\u5360\u521d\u59cb\u968f\u673a\u5206\u7ec4\u60a3\u8005\u768411.8%\uff09\u60a3\u8005\u5728LTE\u7814\u7a76\u671f\u95f4\u9000\u51fa\u7814\u7a76\uff1a7\u4f8b\uff086.4%\uff09\u56e0\u7597\u6548\u4e0d\u4f73\uff0c6\u4f8b\uff085.5%\uff09\u56e0\u4e0d\u826f\u4e8b\u4ef6\uff08AE\uff09\u9000\u51fa\u3002\u5728\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSC\uff09\u8054\u5408\u5e72\u6270\u7d20-\u03b3\uff08IFN-\u03b3\uff09\u6cbb\u7597\u7ec4\u4e2d\uff0c\u67092\u4f8b\u9000\u51fa\u7814\u7a76\u7684\u60a3\u8005\u4e0d\u4ec5\u51fa\u73b0\u4e86\u65b0\u53d1\u7684\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\uff0c\u800c\u4e14\u672a\u80fd\u8fbe\u5230ACR20\u7f13\u89e3\u6807\u51c6\u3002\u5728\u5b8c\u62105\u5e74\u968f\u8bbf\u768497\u4f8b\u60a3\u8005\u4e2d\uff0c69\u4f8b\u63a5\u53d7\u4e86MSC\u5355\u836f\u6cbb\u7597\uff0c28\u4f8b\u63a5\u53d7\u4e86MSC\u8054\u5408IFN-\u03b3\u6cbb\u7597\u3002\u6700\u957f\u968f\u8bbf\u65f6\u95f4\u4e3a7\u5e74\uff0c\u5e73\u5747\u968f\u8bbf\u65f6\u95f4\u4e3a6\u5e74\uff08\u8303\u56f4\uff1a5-7\u5e74\uff09\u3002 MSC \u6cbb\u7597\u7ec4\u7684\u4eba\u53e3\u7edf\u8ba1\u5b66\u548c\u4e34\u5e8a\u200b\u200b\u7279\u5f81\u5e73\u8861\u826f\u597d\uff08\u88681<\/span><span dir=\"auto\">\uff09\uff0c\u5b8c\u6210\u7814\u7a76\u8005\u548c\u9000\u51fa\u7814\u7a76\u8005\u4e4b\u95f4\u7684\u4eba\u53e3\u7edf\u8ba1\u5b66\u548c\u4e34\u5e8a\u200b\u200b\u7279\u5f81\u4e5f\u5e73\u8861\u826f\u597d<\/span><span dir=\"auto\">The<\/span><\/p>\n<table class=\"data last-table\" style=\"width: 41.9119%;\">\n<thead class=\"c-article-table-head\">\n<tr>\n<th class=\"u-text-left\" style=\"width: 36.5517%;\"><span dir=\"auto\">\u7279\u5f81<\/span><\/th>\n<th class=\"u-text-left\" style=\"width: 25.8621%;\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">MSCs\uff08<\/span><\/span><\/span><i><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">N<\/span><\/span><\/span><\/i><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u00a0\u2009= 69\uff09<\/span><\/span><\/span><sup><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">#<\/span><\/span><\/span><\/sup><\/th>\n<th class=\"u-text-left\" style=\"width: 35.8621%;\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">MSCs + IFN-\u03b3 (\u00a0 <\/span><\/span><\/span><i><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">N<\/span><\/span><\/span><\/i><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u00a0\u2009= 28)\u00a0 <\/span><\/span><\/span><sup><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">#<\/span><\/span><\/span><\/sup><\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td class=\"u-text-left\" style=\"width: 36.5517%;\"><span dir=\"auto\">\u5973\u6027\u4eba\u6570\uff08%\uff09<\/span><\/td>\n<td class=\"u-text-left\" style=\"width: 25.8621%;\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">59 (85.5)<\/span><\/span><\/span><\/td>\n<td class=\"u-text-left\" style=\"width: 35.8621%;\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">24 (85.7)<\/span><\/span><\/span><\/td>\n<\/tr>\n<tr>\n<td class=\"u-text-left\" style=\"width: 36.5517%;\"><span dir=\"auto\">\u5e73\u5747\u5e74\u9f84\uff08\u5c81\uff09<\/span><\/td>\n<td class=\"u-text-left\" style=\"width: 25.8621%;\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">46.7 \u00b1 10.2<\/span><\/span><\/span><\/td>\n<td class=\"u-text-left\" style=\"width: 35.8621%;\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">47.4 \u00b1 10.8<\/span><\/span><\/span><\/td>\n<\/tr>\n<tr>\n<td class=\"u-text-left\" style=\"width: 36.5517%;\"><span dir=\"auto\">\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\u5e73\u5747\u75c5\u7a0b\uff08\u5e74\uff09<\/span><\/td>\n<td class=\"u-text-left\" style=\"width: 25.8621%;\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">4.02 \u00b1 2.4<\/span><\/span><\/span><\/td>\n<td class=\"u-text-left\" style=\"width: 35.8621%;\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">4.13 \u00b1 2.6<\/span><\/span><\/span><\/td>\n<\/tr>\n<tr>\n<td class=\"u-text-left\" style=\"width: 36.5517%;\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">DAS28-ESR<\/span><\/span><\/span><\/td>\n<td class=\"u-text-left\" style=\"width: 25.8621%;\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">5.72 \u00b1 0.56<\/span><\/span><\/span><\/td>\n<td class=\"u-text-left\" style=\"width: 35.8621%;\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">5.70 \u00b1 0.47<\/span><\/span><\/span><\/td>\n<\/tr>\n<tr>\n<td class=\"u-text-left\" style=\"width: 36.5517%;\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">HAQ-DI<\/span><\/span><\/span><\/td>\n<td class=\"u-text-left\" style=\"width: 25.8621%;\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">1.63 \u00b1 0.21<\/span><\/span><\/span><\/td>\n<td class=\"u-text-left\" style=\"width: 35.8621%;\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">1.60 \u00b1 0.20<\/span><\/span><\/span><\/td>\n<\/tr>\n<tr>\n<td class=\"u-text-left\" style=\"width: 36.5517%;\"><span dir=\"auto\">\u7ea2\u7ec6\u80de\u6c89\u964d\u7387\uff08\u6beb\u7c73\/\u5c0f\u65f6\uff09<\/span><\/td>\n<td class=\"u-text-left\" style=\"width: 25.8621%;\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">45.87 \u00b1 9.39<\/span><\/span><\/span><\/td>\n<td class=\"u-text-left\" style=\"width: 35.8621%;\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">46.59 \u00b1 8.62<\/span><\/span><\/span><\/td>\n<\/tr>\n<tr>\n<td class=\"u-text-left\" style=\"width: 36.5517%;\"><span dir=\"auto\">C\u53cd\u5e94\u86cb\u767d\u6c34\u5e73\uff08\u6beb\u514b\/\u5347\uff09<\/span><\/td>\n<td class=\"u-text-left\" style=\"width: 25.8621%;\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">24.13 \u00b1 5.83<\/span><\/span><\/span><\/td>\n<td class=\"u-text-left\" style=\"width: 35.8621%;\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">23.43 \u00b1 6.38<\/span><\/span><\/span><\/td>\n<\/tr>\n<tr>\n<td class=\"u-text-left\" style=\"width: 36.5517%;\"><span dir=\"auto\">\u7c7b\u98ce\u6e7f\u56e0\u5b50\u9633\u6027\u7387\uff08%\uff09<\/span><\/td>\n<td class=\"u-text-left\" style=\"width: 25.8621%;\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">95.7<\/span><\/span><\/span><\/td>\n<td class=\"u-text-left\" style=\"width: 35.8621%;\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">96.4<\/span><\/span><\/span><\/td>\n<\/tr>\n<tr>\n<td class=\"u-text-left\" style=\"width: 36.5517%;\"><span dir=\"auto\">\u6297CCP\u6297\u4f53\u9633\u6027\u7387\uff08%\uff09<\/span><\/td>\n<td class=\"u-text-left\" style=\"width: 25.8621%;\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">94.2<\/span><\/span><\/span><\/td>\n<td class=\"u-text-left\" style=\"width: 35.8621%;\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">92.9<\/span><\/span><\/span><\/td>\n<\/tr>\n<tr>\n<td class=\"u-text-left\" style=\"width: 36.5517%;\"><span dir=\"auto\">\u7528\u836f\u53f2\u7f16\u53f7\uff08%\uff09<\/span><\/td>\n<td class=\"u-text-left\" style=\"width: 25.8621%;\"><\/td>\n<td class=\"u-text-left\" style=\"width: 35.8621%;\"><\/td>\n<\/tr>\n<tr>\n<td class=\"u-text-left\" style=\"width: 36.5517%;\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u00a0DMARDs<\/span><\/span><\/span><\/td>\n<td class=\"u-text-left\" style=\"width: 25.8621%;\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">69 (100)<\/span><\/span><\/span><\/td>\n<td class=\"u-text-left\" style=\"width: 35.8621%;\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">28 (100)<\/span><\/span><\/span><\/td>\n<\/tr>\n<tr>\n<td class=\"u-text-left\" style=\"width: 36.5517%;\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u751f\u7269\u5236\u5242<\/span><\/span><\/span><\/td>\n<td class=\"u-text-left\" style=\"width: 25.8621%;\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">27 (39)<\/span><\/span><\/span><\/td>\n<td class=\"u-text-left\" style=\"width: 35.8621%;\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">13\uff0846\uff09<\/span><\/span><\/span><\/td>\n<\/tr>\n<tr>\n<td class=\"u-text-left\" style=\"width: 36.5517%;\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u975e\u753e\u4f53\u6297\u708e\u836f<\/span><\/span><\/span><\/td>\n<td class=\"u-text-left\" style=\"width: 25.8621%;\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">69 (100)<\/span><\/span><\/span><\/td>\n<td class=\"u-text-left\" style=\"width: 35.8621%;\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">28 (100)<\/span><\/span><\/span><\/td>\n<\/tr>\n<tr>\n<td class=\"u-text-left\" style=\"width: 36.5517%;\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u00a0\u5f3a\u7684\u677e<\/span><\/span><\/span><\/td>\n<td class=\"u-text-left\" style=\"width: 25.8621%;\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">59\uff0886\uff09<\/span><\/span><\/span><\/td>\n<td class=\"u-text-left\" style=\"width: 35.8621%;\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">25 (89)<\/span><\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<blockquote><p>HAQ-DI\uff0c\u5065\u5eb7\u8bc4\u4f30\u95ee\u5377-\u6b8b\u75be\u6307\u6570\uff1bDAS28-ESR\uff0c\u57fa\u4e8e\u7ea2\u7ec6\u80de\u6c89\u964d\u7387\u768428\u4e2a\u5173\u8282\u75be\u75c5\u6d3b\u52a8\u5ea6\u8bc4\u5206\uff1bDMARDs\uff0c\u6539\u5584\u75c5\u60c5\u6297\u98ce\u6e7f\u836f\uff1bbDMARDs\uff0c\u751f\u7269\u5236\u5242DMARDs\uff1bNSAIDs\uff0c\u975e\u753e\u4f53\u7c7b\u6297\u708e\u836f\uff1bCCP\uff0c\u73af\u74dc\u6c28\u9178\u80bd\u3002<\/p><\/blockquote>\n<h2><span class=\"ez-toc-section\" id=\"%E9%97%B4%E5%85%85%E8%B4%A8%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E7%B1%BB%E9%A3%8E%E6%B9%BF%E5%85%B3%E8%8A%82%E7%82%8E%E7%9A%84%E5%AE%89%E5%85%A8%E6%80%A7\"><\/span>\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6cbb\u7597\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\u7684\u5b89\u5168\u6027<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span dir=\"auto\">\u968f\u8bbf\u671f\u95f4\u5171\u8bb0\u5f55\u5230223\u4f8b\u4e0d\u826f\u4e8b\u4ef6\uff08AE\uff09\uff0cMSC\u5355\u836f\u6cbb\u7597\u7ec4\u7684\u6bcf100\u4eba\u5e74\u4e0d\u826f\u4e8b\u4ef6\u53d1\u751f\u7387\uff08ER\uff09\u4e3a36.17\uff0cMSC\u8054\u5408IFN-\u03b3\u6cbb\u7597\u7ec4\u4e3a35.86\uff08\u88682<\/span><span dir=\"auto\">\uff09\u3002<\/span><\/p>\n<p class=\"ds-markdown-paragraph\">\u9996\u5148\uff0c<strong>\u5728\u603b\u4f53\u548c\u5e38\u89c1\u4e0d\u826f\u4e8b\u4ef6\u65b9\u9762\uff0c\u5e72\u7ec6\u80de\u6cbb\u7597\u8868\u73b0\u51fa\u53ef\u63a5\u53d7\u7684\u5b89\u5168\u6027\u3002\u4e24\u79cd\u6cbb\u7597\u65b9\u6848\uff08MSCs\u5355\u836f\u548cMSCs\u8054\u5408IFN-\u03b3\uff09\u7684\u603b\u4f53\u4e0d\u826f\u4e8b\u4ef6\u53d1\u751f\u7387\u76f8\u8fd1<\/strong>\u3002\u6700\u5e38\u89c1\u7684\u5f02\u5e38\u662f\u6cbb\u7597\u540e\u4e00\u8fc7\u6027\u7684\u6dcb\u5df4\u7ec6\u80de\u8ba1\u6570\u4e0b\u964d\uff0c\u4f46\u5747\u5c5e\u8f7b\u4e2d\u5ea6\u4e14\u80fd\u5728\u77ed\u671f\u5185\u81ea\u884c\u6062\u590d\uff0c\u672a\u5f71\u54cd\u540e\u7eed\u6cbb\u7597\u3002\u5176\u4ed6\u5e38\u89c4\u68c0\u67e5\u672a\u89c1\u660e\u663e\u5f02\u5e38\uff0c\u8868\u660e\u8be5\u7597\u6cd5\u672a\u5bf9\u4e3b\u8981\u810f\u5668\u529f\u80fd\u4ea7\u751f\u663e\u8457\u5f71\u54cd\u3002<\/p>\n<div id=\"attachment_20542\" style=\"width: 1134px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-20542\" class=\"wp-image-20542 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-18_172849_462.png\" alt=\"\" width=\"1124\" height=\"697\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-18_172849_462.png 1124w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-18_172849_462-300x186.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-18_172849_462-1024x635.png 1024w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-18_172849_462-768x476.png 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-18_172849_462-18x12.png 18w\" sizes=\"(max-width: 1124px) 100vw, 1124px\" \/><p id=\"caption-attachment-20542\" class=\"wp-caption-text\">\u88682 \u4e0d\u826f\u4e8b\u4ef6\u6c47\u603b<\/p><\/div>\n<p class=\"ds-markdown-paragraph\">\u5176\u6b21\uff0c\u5728\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\u65b9\u9762\uff0c\u5176\u603b\u4f53\u53d1\u751f\u7387\u8f83\u4f4e\u3002<span dir=\"auto\">\u5171\u67098\u4f8b\uff087.3%\uff09\u60a3\u8005\u51fa\u73b0\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\uff08SAE\uff09\uff0cMSC\u5355\u836f\u6cbb\u7597\u7ec4\u7684\u53d1\u751f\u7387\u4e3a2.47\/100\u4eba\u5e74\uff0cMSC\u8054\u5408IFN-\u03b3\u6cbb\u7597\u7ec4\u7684\u53d1\u751f\u7387\u4e3a2.31\/100\u4eba\u5e74\u3002\u6700\u5e38\u89c1\u7684SAE\u4e3a\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u548c\u611f\u67d3\u3002MSC\u5355\u836f\u6cbb\u7597\u7ec4\u548cMSC\u8054\u5408IFN-\u03b3\u6cbb\u7597\u7ec4\u7684\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u53d1\u751f\u7387\u5206\u522b\u4e3a0.45\/100\u4eba\u5e74\u548c1.16\/100\u4eba\u5e74\uff08\u88682<\/span><span dir=\"auto\">\uff09\uff0c\u5305\u62ec\u65b0\u53d1\u7cfb\u7edf\u6027\u7ea2\u6591\u72fc\u75ae\uff08SLE\uff09\u548c\u5e72\u71e5\u7efc\u5408\u5f81\u3002\u4e25\u91cd\u611f\u67d3\u4ec5\u53d1\u751f\u4e8eMSC\u5355\u836f\u6cbb\u7597\u7ec4\uff0c\u53d1\u751f\u7387\u4e3a0.45\/100\u4eba\u5e74\uff08\u88682<\/span><span dir=\"auto\">\uff09\u3002<\/span><\/p>\n<p class=\"ds-markdown-paragraph\">\u4e25\u91cd\u4e8b\u4ef6\u4e3b\u8981\u5305\u62ec\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u548c\u611f\u67d3\uff0c\u4f46\u53d1\u751f\u7387\u5747\u5904\u4e8e\u8f83\u4f4e\u6c34\u5e73\u3002\u4e2a\u522b\u4e25\u91cd\u611f\u67d3\u75c5\u4f8b\u5b58\u5728\u590d\u6742\u7684\u5408\u5e76\u75c7\u80cc\u666f\u3002<strong>\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u6574\u4e2a\u7814\u7a76\u671f\u95f4\u672a\u53d1\u751f\u4e0e\u6cbb\u7597\u76f4\u63a5\u76f8\u5173\u7684\u79fb\u690d\u7269\u6297\u5bbf\u4e3b\u75c5\u6216\u6b7b\u4ea1\u4e8b\u4ef6\uff0c\u8fd9\u8fdb\u4e00\u6b65\u652f\u6301\u4e86\u8be5\u7597\u6cd5\u5728\u957f\u671f\u5e94\u7528\u4e2d\u7684\u5b89\u5168\u53ef\u63a7\u6027<\/strong>The<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%E9%97%B4%E5%85%85%E8%B4%A8%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E7%B1%BB%E9%A3%8E%E6%B9%BF%E5%85%B3%E8%8A%82%E7%82%8E%E7%9A%84%E4%B8%B4%E5%BA%8A%E7%96%97%E6%95%88\"><\/span>\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6cbb\u7597\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\u7684\u4e34\u5e8a\u7597\u6548<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<h3 id=\"Sec14\" class=\"c-article__sub-heading c-article__sub-heading--small\"><span class=\"ez-toc-section\" id=\"%E7%96%BE%E7%97%85%E6%B4%BB%E5%8A%A8%E6%80%A7\"><\/span><span dir=\"auto\">\u75be\u75c5\u6d3b\u52a8\u6027<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p class=\"ds-markdown-paragraph\">\u6839\u636e\u7597\u6548\u8bc4\u4f30\uff0c\u5bf9\u4e8e\u6d3b\u52a8\u6027\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\uff0c<strong>\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u8054\u5408IFN-\u03b3\u7597\u6cd5\u76f8\u8f83\u4e8e\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u5355\u836f\u6cbb\u7597\u80fd\u5e26\u6765\u66f4\u663e\u8457\u7684\u4e34\u5e8a\u548c\u529f\u80fd\u6539\u5584\u3002\u5728\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\u671f\u95f4\uff0c\u8054\u5408\u6cbb\u7597\u7ec4\u7684ACR20\u7f13\u89e3\u7387\u9ad8\u8fbe100%\uff0c\u800c\u5355\u836f\u6cbb\u7597\u7ec4\u4e3a50.7%\uff1b\u5728DAS28\u4f4e\u75be\u75c5\u6d3b\u52a8\u5ea6\uff08\u22643.2\uff09\u6307\u6807\u4e0a\uff0c\u8054\u5408\u6cbb\u7597\u7ec4\u4e5f\u8fbe\u523039.3%\uff0c\u8fdc\u9ad8\u4e8e\u5355\u836f\u7ec4\u76848.7%\uff08\u88683\uff09<\/strong>\u3002\u5e76\u4e14\uff0c\u8fd9\u4e00\u7597\u6548\u4f18\u52bf\u5728\u957f\u671f\u6269\u5c55\u7814\u7a76\u7684\u7b2c\u4e94\u5e74\u4f9d\u7136\u4fdd\u6301\u7a33\u5b9a\uff0c\u5176\u65f6\u8054\u5408\u6cbb\u7597\u7ec4\u7684ACR20\u7f13\u89e3\u7387\u548c\u4f4e\u75be\u75c5\u6d3b\u52a8\u5ea6\u7387\u5206\u522b\u4e3a89.3%\u548c42.9%\uff0c\u800c\u5355\u836f\u7ec4\u5219\u4e3a44.9%\u548c8.7%\u3002<\/p>\n<div id=\"attachment_20544\" style=\"width: 1146px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-20544\" class=\"wp-image-20544 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-18_175859_387.png\" alt=\"\" width=\"1136\" height=\"426\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-18_175859_387.png 1136w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-18_175859_387-300x113.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-18_175859_387-1024x384.png 1024w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-18_175859_387-768x288.png 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-18_175859_387-18x7.png 18w\" sizes=\"(max-width: 1136px) 100vw, 1136px\" \/><p id=\"caption-attachment-20544\" class=\"wp-caption-text\">\u88683 \u7597\u6548\u8bc4\u4f30<\/p><\/div>\n<p class=\"ds-markdown-paragraph\">\u5373\u4f7f\u5728\u66f4\u4e25\u683c\u7684\u7f13\u89e3\u6807\u51c6\u4e0b\uff0c<strong>\u8054\u5408\u7597\u6cd5\u4e5f\u663e\u793a\u51fa\u4f18\u52bf\u3002\u867d\u7136ACR50\/70\u548cDAS28\u7f13\u89e3\uff08&lt;2.6\uff09\u7684\u7ec4\u95f4\u5dee\u5f02\u672a\u8fbe\u7edf\u8ba1\u5b66\u663e\u8457\u6027\uff0c\u4f46\u5728\u957f\u671f\u6269\u5c55\u7814\u7a76\u7684\u7b2c\u4e09\u5e74\u548c\u7b2c\u4e94\u5e74\uff0c\u8054\u5408\u6cbb\u7597\u7ec4\u7684DAS28\u7f13\u89e3\u7387\u5747\u8fbe\u523025%\uff0c\u663e\u8457\u9ad8\u4e8e\u5355\u836f\u7ec4\u76841.4%\u548c2.9%<\/strong>\u3002\u6b64\u5916\uff0c\u4ece\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\u7b2c\u4e00\u5e74\u5230\u957f\u671f\u6269\u5c55\u7814\u7a76\u7b2c\u4e94\u5e74\uff0c\u4ee3\u8868\u75be\u75c5\u6d3b\u52a8\u5ea6\u548c\u529f\u80fd\u72b6\u6001\u7684DAS28\u4e0eHAQ-DI\u8bc4\u5206\u4e0b\u964d\u5747\u8d8b\u4e8e\u7a33\u5b9a\uff08\u56fe2\uff09\u3002<\/p>\n<div id=\"attachment_20543\" style=\"width: 1982px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-20543\" class=\"wp-image-20543 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5fae\u4fe1\u56fe\u7247_2025-11-18_180531_106.png\" alt=\"\" width=\"1972\" height=\"2540\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5fae\u4fe1\u56fe\u7247_2025-11-18_180531_106.png 1972w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5fae\u4fe1\u56fe\u7247_2025-11-18_180531_106-233x300.png 233w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5fae\u4fe1\u56fe\u7247_2025-11-18_180531_106-795x1024.png 795w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5fae\u4fe1\u56fe\u7247_2025-11-18_180531_106-768x989.png 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5fae\u4fe1\u56fe\u7247_2025-11-18_180531_106-1193x1536.png 1193w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5fae\u4fe1\u56fe\u7247_2025-11-18_180531_106-1590x2048.png 1590w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5fae\u4fe1\u56fe\u7247_2025-11-18_180531_106-9x12.png 9w\" sizes=\"(max-width: 1972px) 100vw, 1972px\" \/><p id=\"caption-attachment-20543\" class=\"wp-caption-text\">\u56fe2\uff1a\u5bf9\u968f\u8bbf\u671f\u95f4\u8fbe\u5230DAS28\u7f13\u89e3\u3001DAS28\u4f4e\u75be\u75c5\u6d3b\u52a8\u5ea6 (LDA) \u6216 ACR20\/50\/70\u7684\u7c7b\u98ce\u6e7f\u5173\u8282\u708e (RA) \u60a3\u8005\u8fdb\u884c\u751f\u5b58\u5206\u6790<\/p><\/div>\n<\/div>\n<div id=\"Sec8-content\" class=\"c-article-section__content\">\n<p class=\"ds-markdown-paragraph\">\u5bf9\u7597\u6548\u6301\u7eed\u6027\u7684\u5206\u6790\u8868\u660e\uff0c\u4e24\u79cd\u6cbb\u7597\u65b9\u6848\u7684\u4e34\u5e8a\u6548\u679c\u5728\u672b\u6b21\u968f\u8bbf\u65f6\u5747\u4fdd\u6301\u7a33\u5b9a\u3002\u5728\u6574\u4e2a\u957f\u671f\u6269\u5c55\u7814\u7a76\u671f\u95f4\uff0c\u4e24\u7ec4\u7684\u75be\u75c5\u6d3b\u52a8\u5ea6\u96c6\u7fa4\u53d8\u5316\u76f8\u5bf9\u7a33\u5b9a\uff0c\u4f46\u8054\u5408\u6cbb\u7597\u7ec4\u7684\u6539\u5584\u66f4\u4e3a\u660e\u663e\uff0c\u5176\u5927\u591a\u6570\u60a3\u8005\u8fbe\u5230\u4e86\u4e2d\u5ea6\u6216\u4f4e\u5ea6\u75be\u75c5\u6d3b\u52a8\u5ea6\uff0c\u5e76\u6709\u5c11\u6570\u60a3\u8005\u5b9e\u73b0\u7f13\u89e3\uff0c\u8fd9\u8fdb\u4e00\u6b65\u8bc1\u5b9e\u4e86\u8054\u5408\u7b56\u7565\u5728\u957f\u671f\u75be\u75c5\u63a7\u5236\u4e0a\u7684\u4f18\u8d8a\u6027\u3002<\/p>\n<h3><span class=\"ez-toc-section\" id=\"%E7%94%A8%E8%8D%AF%E6%96%B9%E6%A1%88\"><\/span><strong>\u7528\u836f\u65b9\u6848<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u4e0e\u89c2\u5bdf\u5230\u7684\u4e34\u5e8a\u7597\u6548\u4e00\u81f4\uff0c\u7528\u836f\u65b9\u6848\u8c03\u6574\u663e\u793a\uff0c\u5728\u957f\u671f\u6269\u5c55\u7814\u7a76\u671f\u95f4\uff0c\u4e24\u4e2aMSCs\u7ec4\u4e2d\u4f7f\u7528\u751f\u7269DMARDs\u548c\u6cfc\u5c3c\u677e\u7684\u60a3\u8005\u6570\u91cf\u5747\u6709\u6240\u51cf\u5c11\uff0c\u540c\u65f6\u7ef4\u6301\u4e86csDMARDs\u7684\u951a\u5b9a\u6cbb\u7597\uff08\u88684\uff09\u3002<\/p>\n<table class=\"data last-table\">\n<thead class=\"c-article-table-head\">\n<tr>\n<th class=\"u-text-left\" rowspan=\"2\"><span dir=\"auto\">\u00a0\u836f\u7269\u53d8\u66f4\u7f16\u53f7\uff08%\uff09<\/span><\/th>\n<th class=\"u-text-left\" colspan=\"3\"><span dir=\"auto\">\u57fa\u7ebf<\/span><\/th>\n<th class=\"u-text-left\" colspan=\"3\"><span dir=\"auto\">\u4e00\u5e74<\/span><\/th>\n<th class=\"u-text-left\" colspan=\"3\"><span dir=\"auto\">\u4e09\u5e74<\/span><\/th>\n<th class=\"u-text-left\" colspan=\"3\"><span dir=\"auto\">\u4e94\u5e74<\/span><\/th>\n<\/tr>\n<tr>\n<th class=\"u-text-left\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">MSCs\uff08N=69\uff09<\/span><\/span><\/span><\/th>\n<th class=\"u-text-left\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">MSCs+IFN-\u03b3\uff08N=28\uff09<\/span><\/span><\/span><\/th>\n<th class=\"u-text-left\"><i><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">p<\/span><\/span><\/span><\/i><\/th>\n<th class=\"u-text-left\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">MSCs\uff08N=69\uff09<\/span><\/span><\/span><\/th>\n<th class=\"u-text-left\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">MSCs+IFN-\u03b3\uff08N=28\uff09<\/span><\/span><\/span><\/th>\n<th class=\"u-text-left\"><i><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">p<\/span><\/span><\/span><\/i><\/th>\n<th class=\"u-text-left\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">MSCs\uff08N=69\uff09<\/span><\/span><\/span><\/th>\n<th class=\"u-text-left\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">MSCs+IFN-\u03b3\uff08N=28\uff09<\/span><\/span><\/span><\/th>\n<th class=\"u-text-left\"><i><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">p<\/span><\/span><\/span><\/i><\/th>\n<th class=\"u-text-left\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">MSCs\uff08N=69\uff09<\/span><\/span><\/span><\/th>\n<th class=\"u-text-left\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">MSCs+IFN-\u03b3\uff08N=28\uff09<\/span><\/span><\/span><\/th>\n<th class=\"u-text-left\"><i><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">p<\/span><\/span><\/span><\/i><\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td class=\"u-text-left\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">csDMARDs<\/span><\/span><\/span><\/td>\n<td class=\"u-text-left\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">69 (100)<\/span><\/span><\/span><\/td>\n<td class=\"u-text-left\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">28 (100)<\/span><\/span><\/span><\/td>\n<td class=\"u-text-left\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">&gt;0.999<\/span><\/span><\/span><\/td>\n<td class=\"u-text-left\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">69 (100)<\/span><\/span><\/span><\/td>\n<td class=\"u-text-left\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">26 (93)<\/span><\/span><\/span><\/td>\n<td class=\"u-text-left\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">0.081<\/span><\/span><\/span><\/td>\n<td class=\"u-text-left\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">69 (100)<\/span><\/span><\/span><\/td>\n<td class=\"u-text-left\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">26 (93)<\/span><\/span><\/span><\/td>\n<td class=\"u-text-left\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">0.081<\/span><\/span><\/span><\/td>\n<td class=\"u-text-left\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">69 (100)<\/span><\/span><\/span><\/td>\n<td class=\"u-text-left\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">26 (93)<\/span><\/span><\/span><\/td>\n<td class=\"u-text-left\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">0.081<\/span><\/span><\/span><\/td>\n<\/tr>\n<tr>\n<td class=\"u-text-left\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">tsDMARDs<\/span><\/span><\/span><\/td>\n<td class=\"u-text-left\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">0<\/span><\/span><\/span><\/td>\n<td class=\"u-text-left\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">0<\/span><\/span><\/span><\/td>\n<td class=\"u-text-left\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">&gt;0.999<\/span><\/span><\/span><\/td>\n<td class=\"u-text-left\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">0<\/span><\/span><\/span><\/td>\n<td class=\"u-text-left\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">0<\/span><\/span><\/span><\/td>\n<td class=\"u-text-left\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">&gt;0.999<\/span><\/span><\/span><\/td>\n<td class=\"u-text-left\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">2\uff083\uff09<\/span><\/span><\/span><\/td>\n<td class=\"u-text-left\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">1\uff084\uff09<\/span><\/span><\/span><\/td>\n<td class=\"u-text-left\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">&gt;0.999<\/span><\/span><\/span><\/td>\n<td class=\"u-text-left\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">13\uff0819\uff09<\/span><\/span><\/span><\/td>\n<td class=\"u-text-left\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">1\uff084\uff09<\/span><\/span><\/span><\/td>\n<td class=\"u-text-left\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">0.061<\/span><\/span><\/span><\/td>\n<\/tr>\n<tr>\n<td class=\"u-text-left\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u751f\u7269\u5236\u5242<\/span><\/span><\/td>\n<td class=\"u-text-left\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">27 (39)<\/span><\/span><\/span><\/td>\n<td class=\"u-text-left\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">10\uff0836\uff09<\/span><\/span><\/span><\/td>\n<td class=\"u-text-left\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">0.820<\/span><\/span><\/span><\/td>\n<td class=\"u-text-left\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">13\uff0819\uff09<\/span><\/span><\/span><\/td>\n<td class=\"u-text-left\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">1\uff084\uff09<\/span><\/span><\/span><\/td>\n<td class=\"u-text-left\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">0.061<\/span><\/span><\/span><\/td>\n<td class=\"u-text-left\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">11\uff0816\uff09<\/span><\/span><\/span><\/td>\n<td class=\"u-text-left\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">1\uff084\uff09<\/span><\/span><\/span><\/td>\n<td class=\"u-text-left\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">0.170<\/span><\/span><\/span><\/td>\n<td class=\"u-text-left\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">12\uff0817\uff09<\/span><\/span><\/span><\/td>\n<td class=\"u-text-left\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">2\uff087\uff09<\/span><\/span><\/span><\/td>\n<td class=\"u-text-left\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">0.338<\/span><\/span><\/span><\/td>\n<\/tr>\n<tr>\n<td class=\"u-text-left\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5f3a\u7684\u677e<\/span><\/span><\/td>\n<td class=\"u-text-left\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">57 (83)<\/span><\/span><\/span><\/td>\n<td class=\"u-text-left\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">24\uff0886\uff09<\/span><\/span><\/span><\/td>\n<td class=\"u-text-left\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">&gt;0.999<\/span><\/span><\/span><\/td>\n<td class=\"u-text-left\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">36\uff0852\uff09<\/span><\/span><\/span><\/td>\n<td class=\"u-text-left\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">2\uff087\uff09<\/span><\/span><\/span><\/td>\n<td class=\"u-text-left\"><b><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">&lt;0.001<\/span><\/span><\/span><\/b><\/td>\n<td class=\"u-text-left\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">34\uff0849\uff09<\/span><\/span><\/span><\/td>\n<td class=\"u-text-left\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">2\uff087\uff09<\/span><\/span><\/span><\/td>\n<td class=\"u-text-left\"><b><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">&lt;0.001<\/span><\/span><\/span><\/b><\/td>\n<td class=\"u-text-left\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">23\uff0833\uff09<\/span><\/span><\/span><\/td>\n<td class=\"u-text-left\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">2\uff087\uff09<\/span><\/span><\/span><\/td>\n<td class=\"u-text-left\"><b><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">0.009<\/span><\/span><\/span><\/b><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<blockquote><p><span dir=\"auto\">DMARDs\uff0c\u75be\u75c5\u4fee\u9970\u6297\u98ce\u6e7f\u836f\uff1bcsDMARDs\uff0c\u4f20\u7edf\u5408\u6210DMARDs\uff1btsDMARDs\uff0c\u9776\u5411\u5408\u6210DMARDs\uff1bbDMARDs\uff0c\u751f\u7269DMARDs<\/span><\/p><\/blockquote>\n<p>\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c<strong>\u4e0eMSCs\u5355\u836f\u6cbb\u7597\u7ec4\u76f8\u6bd4\uff0cMSCs\u8054\u5408IFN-\u03b3\u6cbb\u7597\u7ec4\u7684\u6cfc\u5c3c\u677e\u7528\u91cf\u51cf\u5c11\u66f4\u4e3a\u663e\u8457\u3002<\/strong>\u6b64\u5916\uff0c\u81ea2019\u5e74\u9776\u5411\u5408\u6210DMARDs\u5728\u4e2d\u56fd\u83b7\u6279\u540e\uff0c\u4e00\u4e9b\u4e34\u5e8a\u53cd\u5e94\u4e0d\u7406\u60f3\u6216\u8ffd\u6c42\u4e34\u5e8a\u7f13\u89e3\u7684\u60a3\u8005\u9009\u7528\u4e86tsDMARDs\uff0c\u5c3d\u7ba1\u4e24\u7ec4\u95f4\u672a\u89c2\u5bdf\u5230\u663e\u8457\u5dee\u5f02\u3002\u7279\u522b\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u5728MSCs\u8054\u5408IFN-\u03b3\u6cbb\u7597\u7ec4\u4e2d\u6709\u4e00\u4f8b\u60a3\u8005\u5b9e\u73b0\u4e86\u6301\u7eed\u7684\u505c\u836f\u7f13\u89e3\uff0c\u8be5\u60a3\u8005\u5728\u7b2c\u4e00\u4e2a\u968f\u8bbf\u5e74\u5185\u8fbe\u5230\u7f13\u89e3\u5e76\u7ef4\u6301\u81f3\u7b2c\u4e94\u5e74\u3002<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%E8%AE%A8%E8%AE%BA%EF%BC%9A%E9%97%B4%E5%85%85%E8%B4%A8%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E7%B1%BB%E9%A3%8E%E6%B9%BF%E5%85%B3%E8%8A%82%E7%82%8E%E7%9A%84%E7%BB%93%E6%9E%9C\"><\/span>\u8ba8\u8bba\uff1a\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6cbb\u7597\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\u7684\u7ed3\u679c<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p class=\"ds-markdown-paragraph\">\u672c\u7814\u7a76\u8bc1\u5b9e\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6cbb\u7597\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\u5177\u6709\u6301\u7eed\u826f\u597d\u7684\u957f\u671f\u5b89\u5168\u6027\u7279\u5f81\u3002<strong>\u5728\u957f\u8fbe\u4e94\u5e74\u7684\u968f\u8bbf\u671f\u95f4\uff0cMSC\u5355\u836f\u6cbb\u7597\u53caMSC\u8054\u5408IFN-\u03b3\u6cbb\u7597\u5747\u672a\u51fa\u73b0\u65b0\u7684\u5b89\u5168\u6027\u95ee\u9898\uff0c\u5177\u4f53\u8868\u73b0\u4e3a\u6cbb\u7597\u671f\u95f4\u4e0d\u826f\u4e8b\u4ef6\u548c\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\u672a\u968f\u7597\u7a0b\u5ef6\u957f\u800c\u589e\u52a0\uff0c\u4e14\u5168\u7a0b\u65e0\u79fb\u690d\u7269\u6297\u5bbf\u4e3b\u75c5\u548c\u6b7b\u4ea1\u75c5\u4f8b\u62a5\u544a\u3002<\/strong>\u5c3d\u7ba1\u7814\u7a76\u521d\u59cb\u6837\u672c\u91cf\uff08n=110\uff09\u7ecf\u8fc7\u79d1\u5b66\u8ba1\u7b97\uff0c\u4e1488.2%\u7684\u968f\u8bbf\u7387\uff08n=97\uff09\u5728\u540c\u7c7b\u957f\u671f\u7814\u7a76\u4e2d\u8868\u73b0\u5408\u7406\uff0c\u4f46\u7814\u7a76\u8005\u660e\u786e\u6307\u51fa\u6837\u672c\u91cf\u8f83\u5c0f\u4ecd\u662f\u5173\u952e\u5c40\u9650\uff0c\u8fd9\u53ef\u80fd\u5f71\u54cd\u5bf9\u8f83\u5c0f\u4e34\u5e8a\u6548\u5e94\u7684\u68c0\u6d4b\u80fd\u529b\uff0c\u5e76\u9650\u5236\u4e86\u7814\u7a76\u7ed3\u679c\u5411\u66f4\u5e7f\u6cdb\u60a3\u8005\u7fa4\u4f53\u7684\u63a8\u5e7f\u5e94\u7528\u3002<\/p>\n<p class=\"ds-markdown-paragraph\">\u5728\u7597\u6548\u65b9\u9762\uff0c<strong>\u7814\u7a76\u663e\u793a\u5355\u6b21\u8f93\u6ce8MSCs\u540e3-6\u4e2a\u6708\u5185\u5373\u53ef\u4f7f\u591a\u6570\u6709\u6548\u60a3\u8005\u83b7\u5f97\u663e\u8457\u4e34\u5e8a\u6539\u5584\uff0c\u4e14\u6240\u6709\u7597\u6548\u6307\u6807\u5728\u4e94\u5e74\u968f\u8bbf\u671f\u5185\u4fdd\u6301\u7a33\u5b9a\u3002\u867d\u7136MSC\u8054\u5408IFN-\u03b3\u65b9\u6848\u7684\u7597\u6548\u4f18\u4e8e\u5355\u836f\u6cbb\u7597\uff0c\u7279\u522b\u662f\u5728\u4e2d\u5ea6\u75be\u75c5\u6d3b\u52a8\u5ea6\u60a3\u8005\u4e2d\u8868\u73b0\u663e\u8457\uff0c\u4f46\u4e24\u79cd\u65b9\u6848\u5747\u80fd\u4e3a\u5927\u591a\u6570\u60a3\u8005\u63d0\u4f9b\u6301\u4e45\u7684\u4e34\u5e8a\u83b7\u76ca<\/strong>\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u5bf9\u4e8e\u91cd\u5ea6\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\u60a3\u8005\uff0c\u8981\u8fbe\u5230\u6df1\u5ea6\u7f13\u89e3\uff08\u5982ACR50\/70\u6807\u51c6\uff09\u53ef\u80fd\u9700\u8981\u8fdb\u4e00\u6b65\u4f18\u5316\u7ed9\u836f\u7b56\u7565\u3002<\/p>\n<p class=\"ds-markdown-paragraph\">\u6b64\u5916\uff0c\u7814\u7a76\u8fd8\u89c2\u5bdf\u5230\u4e34\u5e8a\u6709\u6548\u60a3\u8005\u5bf9\u6cfc\u5c3c\u677e\u548c\u751f\u7269\u5236\u5242\u7c7b\u6297\u98ce\u6e7f\u836f\u7684\u9700\u6c42\u663e\u8457\u964d\u4f4e\uff0c\u8fd9\u4f53\u73b0\u4e86MSCs\u6cbb\u7597\u7684\u9644\u52a0\u4ef7\u503c\u3002\u7136\u800c\uff0c\u4f5c\u4e3a\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\u7684\u57fa\u7840\u6cbb\u7597\uff0c\u4f20\u7edfDMARDs\u4ecd\u9700\u6301\u7eed\u4f7f\u7528\u4ee5\u786e\u4fdd\u957f\u671f\u7597\u6548\u7684\u7ef4\u6301\u3002\u7814\u7a76\u8005\u5f3a\u8c03\uff0c\u672a\u6765\u9700\u8981\u901a\u8fc7\u66f4\u5927\u89c4\u6a21\u7684\u4e34\u5e8a\u8bd5\u9a8c\u6765\u9a8c\u8bc1\u8fd9\u4e9b\u53d1\u73b0\uff0c\u5e76\u8fdb\u4e00\u6b65\u63d0\u9ad8\u7814\u7a76\u7ed3\u679c\u7684\u666e\u9002\u6027\u3002<\/p>\n<h2 class=\"c-article__sub-heading\" data-test=\"abstract-sub-heading\"><span class=\"ez-toc-section\" id=\"%E6%9C%80%E7%BB%88%E7%BB%93%E8%AE%BA\"><\/span><span dir=\"auto\">\u6700\u7ec8\u7ed3\u8bba<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span dir=\"auto\">\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09\u8054\u5408\u6216\u4e0d\u8054\u5408\u5e72\u6270\u7d20-\u03b3\uff08IFN-\u03b3\uff09\u6cbb\u7597\u7684\u957f\u671f\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u5747\u4fdd\u6301\u7a33\u5b9a\u3002MSCs\u7684\u7597\u6548\u81f3\u5c11\u7ef4\u6301\u4e86\u4e94\u5e74\u3002\u8fd9\u4e9b\u53d1\u73b0\u652f\u6301\u5c06MSCs\u4f5c\u4e3a\u6d3b\u52a8\u6027\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\uff08RA\uff09\u60a3\u8005\u7684\u4e00\u79cd\u6cbb\u7597\u9009\u62e9\u3002<\/span><\/p>\n<blockquote><p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u53c2\u8003\u8d44\u6599\uff1a[1] <\/span><\/span><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">Yang, Y., He, X., Yao, M.\u00a0 <\/span><\/span><i><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">et al.<\/span><\/span><\/i><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u00a0Mesenchymal stem cells combined with IFN-\u03b3 treatment versus mesenchymal stem cells monotherapy: safety and efficacy over five years extension follow-up.\u00a0 <\/span><\/span><i><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">Stem Cell Res Ther <\/span><\/span><\/i>\u00a0<b><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">16<\/span><\/span><\/b><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> , 642 (2025). https:\/\/doi.org\/10.1186\/s13287-025-04772-x<\/span><\/span><\/p><\/blockquote>\n<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>\u4e3a\u4e86\u62a5\u544a\u95f4\u5145\u8d28\u5e72\u7ec6\u80de (MSC) \u4e0e IFN-\u03b3 \u8054\u5408\u6216\u4e0d\u8054\u5408\u6cbb\u7597\u7c7b\u98ce\u6e7f\u6027\u5173\u8282\u708e (RA) \u60a3\u8005\u7684\u957f\u671f\u5b89\u5168\u6027\u548c [&hellip;]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[61],"tags":[230,229,178],"_links":{"self":[{"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/posts\/20541"}],"collection":[{"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/comments?post=20541"}],"version-history":[{"count":1,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/posts\/20541\/revisions"}],"predecessor-version":[{"id":20548,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/posts\/20541\/revisions\/20548"}],"wp:attachment":[{"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/media?parent=20541"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/categories?post=20541"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/tags?post=20541"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}