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id=\"%E9%97%B4%E5%85%85%E8%B4%A8%E5%B9%B2%E7%BB%86%E8%83%9E%E4%BF%AE%E5%A4%8D5%E5%A4%A7%E9%87%8D%E8%A6%81%E5%99%A8%E5%AE%98%E6%8D%9F%E4%BC%A4%E4%B8%AD%E7%9A%84%E4%BD%9C%E7%94%A8%EF%BC%9A%E4%BB%8E%E6%9C%BA%E5%88%B6%E5%88%B0%E4%B8%B4%E5%BA%8A%E5%BA%94%E7%94%A8\"><\/span>\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u4fee\u590d5\u5927\u91cd\u8981\u5668\u5b98\u635f\u4f24\u4e2d\u7684\u4f5c\u7528\uff1a\u4ece\u673a\u5236\u5230\u4e34\u5e8a\u5e94\u7528<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<section data-role=\"paragraph\" data-pm-slice=\"4 3 [&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;outer&quot;,&quot;class&quot;:&quot;article135&quot;,&quot;label&quot;:&quot;edit by 135editor&quot;,&quot;data-pm-slice&quot;:&quot;0 0 []&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;}]\">\u8fd1\u671f\uff0c\u6e56\u5357\u5e08\u8303\u5927\u5b66\u533b\u5b66\u90e8\u8054\u5408\u957f\u6c99\u5e02\u5987\u5e7c\u4fdd\u5065\u9662\u5987\u4ea7\u79d1\u7b49\u673a\u6784\u5728\u300aAm J Stem Cells\u300b\u671f\u520a\u4e0a\u53d1\u8868\u4e86\u4e00\u7bc7\u9898\u4e3a<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12267123\/#ref-list1\" target=\"_blank\" rel=\"noopener nofollow\">\u201c\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u5728\u91cd\u8981\u5668\u5b98\u635f\u4f24\u4fee\u590d\u4e2d\u7684\u4f5c\u7528\uff1a\u4ece\u673a\u5236\u5230\u4e34\u5e8a\u5e94\u7528\u201d<\/a>\u7684\u7814\u7a76\u7efc\u8ff0[1]\u3002<\/p>\n<section><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-20586 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-20_150149_362.png\" 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id=\"%E4%B8%80%E3%80%81%E9%97%B4%E5%85%85%E8%B4%A8%E5%B9%B2%E7%BB%86%E8%83%9E%E5%9C%A8%E4%BF%AE%E5%A4%8D%E5%99%A8%E5%AE%98%E6%8D%9F%E4%BC%A4%E4%B8%AD%E7%9A%84%E6%BD%9C%E5%8A%9B\"><\/span><strong>\u4e00\u3001\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u5728\u4fee\u590d\u5668\u5b98\u635f\u4f24\u4e2d\u7684\u6f5c\u529b<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<h3><span class=\"ez-toc-section\" id=\"%E5%99%A8%E5%AE%98%E6%8D%9F%E4%BC%A4%E7%9A%84%E5%90%AF%E5%8A%A8%E4%B8%8E%E7%82%8E%E7%97%87%E5%BA%94%E7%AD%94\"><\/span>\u5668\u5b98\u635f\u4f24\u7684\u542f\u52a8\u4e0e\u708e\u75c7\u5e94\u7b54<span 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decoding=\"async\" class=\"aligncenter wp-image-20577 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/istockphoto-1491437028-612x612-1.jpg\" alt=\"\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u4fee\u590d5\u5927\u91cd\u8981\u5668\u5b98\u635f\u4f24\u4e2d\u7684\u4f5c\u7528\uff1a\u4ece\u673a\u5236\u5230\u4e34\u5e8a\u5e94\u7528\" width=\"612\" height=\"408\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/istockphoto-1491437028-612x612-1.jpg 612w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/istockphoto-1491437028-612x612-1-300x200.jpg 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/istockphoto-1491437028-612x612-1-18x12.jpg 18w\" sizes=\"(max-width: 612px) 100vw, 612px\" \/><\/section>\n<h3><span class=\"ez-toc-section\" id=\"%E7%BB%84%E7%BB%87%E4%BF%AE%E5%A4%8D%E7%9A%84%E5%90%AF%E5%8A%A8%E4%B8%8E%E6%BD%9C%E5%9C%A8%E9%A3%8E%E9%99%A9\"><\/span>\u7ec4\u7ec7\u4fee\u590d\u7684\u542f\u52a8\u4e0e\u6f5c\u5728\u98ce\u9669<span 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class=\"ez-toc-section\" id=\"%E5%BD%93%E5%89%8D%E4%BF%AE%E5%A4%8D%E7%AD%96%E7%95%A5%E7%9A%84%E5%B1%80%E9%99%90%E4%B8%8E%E6%96%B0%E5%B8%8C%E6%9C%9B\"><\/span>\u5f53\u524d\u4fee\u590d\u7b56\u7565\u7684\u5c40\u9650\u4e0e\u65b0\u5e0c\u671b<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u7136\u800c\uff0c\u5668\u5b98\u4fee\u590d\u9762\u4e34\u8bf8\u591a\u6311\u6218\uff1a\u7ec6\u80de\u81ea\u8eab\u518d\u751f\u80fd\u529b\u6709\u9650\uff0c\u708e\u75c7\u53cd\u5e94\u53cd\u800c\u53ef\u80fd\u963b\u788d\u4fee\u590d\u5e76\u52a0\u5267\u7ea4\u7ef4\u5316\uff0c\u4e14\u529f\u80fd\u5e38\u65e0\u6cd5\u5b8c\u5168\u6062\u590d\u3002<\/p>\n<section data-role=\"paragraph\" data-pm-slice=\"4 3 [&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;outer&quot;,&quot;class&quot;:&quot;article135&quot;,&quot;label&quot;:&quot;edit by 135editor&quot;,&quot;data-pm-slice&quot;:&quot;0 0 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id=\"%E9%97%B4%E5%85%85%E8%B4%A8%E5%B9%B2%E7%BB%86%E8%83%9E%E7%9A%84%E5%A4%9A%E6%9C%BA%E5%88%B6%E4%BF%AE%E5%A4%8D%E4%B8%8E%E4%B8%B4%E5%BA%8A%E8%BD%AC%E5%8C%96\"><\/span>\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u7684\u591a\u673a\u5236\u4fee\u590d\u4e0e\u4e34\u5e8a\u8f6c\u5316<span 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class=\"ez-toc-section\" id=\"%E4%BA%8C%E3%80%81%E9%97%B4%E5%85%85%E8%B4%A8%E5%B9%B2%E7%BB%86%E8%83%9E%E7%9A%84%E7%89%B9%E6%80%A7\"><\/span><strong>\u4e8c\u3001\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u7684\u7279\u6027<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><a href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/mscs\/20023.html\/\" target=\"_blank\" rel=\"noopener\">\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09<\/a>\u6765\u6e90\u4e8e\u591a\u79cd\u7ec4\u7ec7\uff0c\u5176\u4e2d<a href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/mscs\/19975.html\/\" target=\"_blank\" rel=\"noopener\">\u9aa8\u9ad3\u3001\u8102\u80aa\u7ec4\u7ec7\u3001\u8110\u5e26\u8840\u3001\u5916\u5468\u8840\u3001\u7259\u9ad3\u548c\u6708\u7ecf\u8840<\/a>\u7b49\u662f\u7814\u7a76\u70ed\u70b9\u3002<\/p>\n<p>\u6839\u636e2006\u5e74\u5236\u5b9a\u7684\u6807\u51c6\uff0cMSCs\u9700\u5728\u6807\u51c6\u57f9\u517b\u6761\u4ef6\u4e0b\u8d34\u58c1\u751f\u957f\uff0c\u8868\u8fbe\u7279\u5b9a\u7684\u8868\u9762\u6297\u539f\uff0c\u5305\u62ecCD105\u3001CD73\u548cCD90\uff0c\u4e14\u4e0d\u8868\u8fbe\u9020\u8840\u6807\u5fd7\u7269\uff0c\u5982CD45\u3001CD34\u3001CD14\u3001CD11b\u3001CD79a\u548cCD19\uff0c\u4ee5\u53caII\u7c7bHLA\u5206\u5b50\u3002\u6b64\u5916\uff0cMSCs\u8fd8\u5e94\u5177\u6709\u5206\u5316\u4e3a\u6210\u9aa8\u7ec6\u80de\u3001\u8102\u80aa\u7ec6\u80de\u548c\u8f6f\u9aa8\u7ec6\u80de\u7684\u80fd\u529b\u3002<\/p>\n<h3><span class=\"ez-toc-section\" id=\"01%E3%80%81%E9%97%B4%E5%85%85%E8%B4%A8%E5%B9%B2%E7%BB%86%E8%83%9E%E5%88%86%E5%8C%96%E7%9A%84%E8%B0%83%E6%8E%A7\"><\/span>01\u3001\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u5206\u5316\u7684\u8c03\u63a7<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09\u7684\u7b2c\u4e00\u5927\u7279\u6027\u662f\u5176\u591a\u5411\u5206\u5316\u6f5c\u80fd\u3002MSCs\u80fd\u591f\u5206\u5316\u4e3a\u591a\u79cd\u7ec6\u80de\u8c31\u7cfb\uff0c\u5305\u62ec\u9aa8\u7ec6\u80de\u3001\u8f6f\u9aa8\u7ec6\u80de\u3001\u8102\u80aa\u7ec6\u80de\u3001\u808c\u8089\u7ec6\u80de\u3001\u5fc3\u808c\u7ec6\u80de\u3001\u5e73\u6ed1\u808c\u7ec6\u80de\u548c\u5185\u76ae\u7ec6\u80de\uff0c\u4ece\u800c\u6709\u6548\u4fee\u590d\u7ec4\u7ec7\u7f3a\u635f\uff08\u56fe1\uff09\u3002<\/p>\n<p>\u8fd9\u4e00\u5206\u5316\u8fc7\u7a0b\u4e3b\u8981\u53d7\u7279\u5b9a\u8f6c\u5f55\u56e0\u5b50\u8c03\u63a7\uff0c\u4f8b\u5982Runx2\u4fc3\u8fdb\u6210\u9aa8\u5206\u5316\uff0cPPAR\u03b3\u8c03\u63a7\u8102\u80aa\u751f\u6210\uff0cSox9\u4e3b\u5bfc\u8f6f\u9aa8\u751f\u6210\uff0c\u800cPAX3\u548cPax7\u5219\u53c2\u4e0e\u6210\u808c\u5206\u5316\u3002\u8fd9\u4e9b\u8c03\u63a7\u673a\u5236\u4f7fMSCs\u5728\u7ec4\u7ec7\u635f\u4f24\u4fee\u590d\u4e2d\u53d1\u6325\u5173\u952e\u4f5c\u7528\u3002<\/p>\n<section>\n<div id=\"attachment_20585\" style=\"width: 631px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-20585\" class=\"wp-image-20585 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5fae\u4fe1\u56fe\u7247_2025-11-20_150739_544.png\" alt=\"\" width=\"621\" height=\"344\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5fae\u4fe1\u56fe\u7247_2025-11-20_150739_544.png 621w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5fae\u4fe1\u56fe\u7247_2025-11-20_150739_544-300x166.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5fae\u4fe1\u56fe\u7247_2025-11-20_150739_544-18x10.png 18w\" sizes=\"(max-width: 621px) 100vw, 621px\" \/><p id=\"caption-attachment-20585\" class=\"wp-caption-text\">\u56fe1\uff1a\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u5206\u5316\u4e2d\u7684\u8f6c\u5f55\u56e0\u5b50\u8c03\u63a7\u3002\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u5177\u6709\u591a\u79cd\u5206\u5316\u80fd\u529b\uff0c\u53ef\u5206\u5316\u4e3a\u591a\u79cd\u7ec6\u80de\u7c7b\u578b\uff0c\u5305\u62ec\u9aa8\u7ec6\u80de\u3001\u8f6f\u9aa8\u7ec6\u80de\u3001\u8102\u80aa\u7ec6\u80de\u3001\u9aa8\u9abc\u808c\u7ec6\u80de\u3001\u5fc3\u808c\u7ec6\u80de\u3001\u5e73\u6ed1\u808c\u7ec6\u80de\u548c\u5185\u76ae\u7ec6\u80de\u3002\u53c2\u4e0e\u8fd9\u4e9b\u5206\u5316\u8fc7\u7a0b\u7684\u5173\u952e\u8f6c\u5f55\u56e0\u5b50\u5305\u62ecRunx2\u3001Sox9\u3001PPAR\u03b3\u3001Pax3\u3001GATA4\u3001S1P\u548cMRTF\uff0c\u5b83\u4eec\u5404\u81ea\u5728\u8c31\u7cfb\u5b9a\u5411\u8c03\u63a7\u4e2d\u53d1\u6325\u7740\u4e0d\u540c\u7684\u4f5c\u7528\u3002<\/p><\/div>\n<\/section>\n<h3><span class=\"ez-toc-section\" id=\"02%E3%80%81%E9%97%B4%E5%85%85%E8%B4%A8%E5%B9%B2%E7%BB%86%E8%83%9E%E7%9A%84%E5%85%8D%E7%96%AB%E8%B0%83%E8%8A%82\"><\/span>02\u3001\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u7684\u514d\u75ab\u8c03\u8282<span 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id=\"attachment_20584\" style=\"width: 680px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-20584\" class=\"wp-image-20584 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5fae\u4fe1\u56fe\u7247_2025-11-20_150752_745.png\" alt=\"\" width=\"670\" height=\"601\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5fae\u4fe1\u56fe\u7247_2025-11-20_150752_745.png 670w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5fae\u4fe1\u56fe\u7247_2025-11-20_150752_745-300x269.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5fae\u4fe1\u56fe\u7247_2025-11-20_150752_745-13x12.png 13w\" sizes=\"(max-width: 670px) 100vw, 670px\" \/><p id=\"caption-attachment-20584\" class=\"wp-caption-text\">\u56fe2\uff1a\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09\u5177\u6709\u514d\u75ab\u8c03\u8282\u529f\u80fd\u3002MSCs\u53ef\u901a\u8fc7\u5206\u6ccc\u7ec6\u80de\u56e0\u5b50\u548c\u5916\u6ccc\u4f53\u8bf1\u5bfc\u5de8\u566c\u7ec6\u80de\u7531M1\u8868\u578b\u5411M2\u8868\u578b\u6781\u5316\u3002MSCs\u53ef\u6291\u5236\u6811\u7a81\u72b6\u7ec6\u80de\uff08DCs\uff09\u7684\u6210\u719f\uff0c\u4fc3\u8fdbT\u7ec6\u80de\u5411\u8c03\u8282\u6027T\u7ec6\u80de\uff08Tregs\uff09\u5206\u5316\uff0c\u540c\u65f6\u6291\u5236\u5176\u5411Th17\u7ec6\u80de\u5206\u5316\u3002\u6b64\u5916\uff0cMSCs\u53ef\u51cf\u5c11\u4fc3\u708e\u56e0\u5b50\u7684\u5206\u6ccc\uff0c\u5e76\u51cf\u5f31\u708e\u75c7\u4ecb\u8d28\u7684\u589e\u52a0\uff0c\u4ece\u800c\u6291\u5236\u6574\u4f53\u708e\u75c7\u53cd\u5e94\u3002\u6b64\u5916\uff0cMSCs\u8fd8\u53ef\u901a\u8fc7\u7ebf\u7c92\u4f53\u8f6c\u79fb\u5f71\u54cd\u514d\u75ab\u7ec6\u80de\u3002<\/p><\/div>\n<\/section>\n<h3><span class=\"ez-toc-section\" id=\"03%E3%80%81%E9%97%B4%E5%85%85%E8%B4%A8%E5%B9%B2%E7%BB%86%E8%83%9E%E7%BA%BF%E7%B2%92%E4%BD%93%E8%BD%AC%E7%A7%BB\"><\/span>03\u3001\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u7ebf\u7c92\u4f53\u8f6c\u79fb<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u7684\u7b2c\u4e09\u5927\u7279\u6027\u662f\u5176\u7ebf\u7c92\u4f53\u8f6c\u79fb\u80fd\u529b\u3002MSCs\u80fd\u591f\u901a\u8fc7\u8f6c\u79fb\u7ebf\u7c92\u4f53\u6765\u8c03\u8282\u514d\u75ab\u53cd\u5e94\u548c\u4fc3\u8fdb\u7ec4\u7ec7\u4fee\u590d\uff0c\u4f8b\u5982\u5c06\u7ebf\u7c92\u4f53\u8f6c\u79fb\u81f3CD4+T\u7ec6\u80de\u53ef\u589e\u5f3a\u6291\u5236\u6027\u7ec6\u80de\uff08\u5982CD25+FoxP3+\u7ec6\u80de\uff09\u7684\u8868\u8fbe\uff0c\u6539\u5584\u79fb\u690d\u7269\u6297\u5bbf\u4e3b\u75c5\u6a21\u578b\u7684\u5b58\u6d3b\u7387\u3002<\/p>\n<p>\u540c\u65f6\uff0c\u7ebf\u7c92\u4f53\u8f6c\u79fb\u81f3\u5de8\u566c\u7ec6\u80de\u80fd\u63d0\u9ad8\u5176\u541e\u566c\u80fd\u529b\u3002\u7814\u7a76\u8868\u660e\uff0cMSCs\u6765\u6e90\u7684\u7ebf\u7c92\u4f53\u6216\u5916\u6ccc\u4f53\u5728\u5fc3\u808c\u6897\u6b7b\u7b49\u635f\u4f24\u6a21\u578b\u4e2d\u80fd\u4fc3\u8fdb\u8840\u7ba1\u751f\u6210\u3001\u6291\u5236\u7ec6\u80de\u51cb\u4ea1\uff0c\u5e76\u52a0\u901f\u7ec4\u7ec7\u91cd\u5851\uff0c\u8fd9\u51f8\u663e\u4e86\u5176\u5728\u6cbb\u7597\u635f\u4f24\u4fee\u590d\u75be\u75c5\u4e2d\u7684\u6f5c\u529b\u3002<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%E4%B8%89%E3%80%81%E9%97%B4%E5%85%85%E8%B4%A8%E5%B9%B2%E7%BB%86%E8%83%9E%E5%9C%A8%E6%8D%9F%E4%BC%A4%E4%BF%AE%E5%A4%8D%E4%B8%AD%E7%9A%84%E4%BD%9C%E7%94%A8%E6%9C%BA%E5%88%B6%E5%8F%8A%E7%A0%94%E7%A9%B6%E8%BF%9B%E5%B1%95\"><\/span><strong>\u4e09\u3001\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u5728\u635f\u4f24\u4fee\u590d\u4e2d\u7684\u4f5c\u7528\u673a\u5236\u53ca\u7814\u7a76\u8fdb\u5c55<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>\u7531\u4e8e\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09\u5728\u635f\u4f24\u4fee\u590d\u4e2d\u53d1\u6325\u7740\u91cd\u8981\u4f5c\u7528\uff0c\u4eba\u4eec\u5bf9\u5176\u6cbb\u7597\u76f8\u5173\u75be\u75c5\u7684\u6f5c\u529b\u4ea7\u751f\u4e86\u6d53\u539a\u7684\u5174\u8da3\u3002\u76ee\u524d\uff0c\u5927\u91cf\u7684\u79d1\u5b66\u7814\u7a76\u6b63\u5728\u63a2\u7d22MSCs\u5728\u5404\u79cd\u5668\u5b98\u635f\u4f24\u4e2d\u53d1\u6325\u4f5c\u7528\u7684\u5177\u4f53\u673a\u5236\u3002\u4e0e\u6b64\u540c\u65f6\uff0c\u8bb8\u591a\u4e34\u5e8a\u8bd5\u9a8c\u4e5f\u5728\u8fdb\u884c\uff0c\u4ee5\u8bc4\u4f30MSCs\u4fc3\u8fdb\u635f\u4f24\u4fee\u590d\u7684\u6709\u6548\u6027\u3002<\/p>\n<p>\u672c\u6587\u56de\u987e\u4e86\u8fd1\u4e94\u5e74\u6765\u7684\u76f8\u5173\u6587\u732e\uff0c\u7cfb\u7edf\u5730\u9610\u8ff0\u4e86MSCs\u57285\u5927\u5668\u5b98\u635f\u4f24\u4e2d\u7684\u4f5c\u7528\u673a\u5236\uff0c\u5e76\u9610\u8ff0\u76f8\u5173\u4e34\u5e8a\u6848\u4f8b\u3002\u6211\u4eec\u671f\u671b\u8fd9\u4e9b\u7814\u7a76\u548c\u5b9e\u9a8c\u80fd\u591f\u663e\u8457\u63a8\u52a8MSCs\u7597\u6cd5\u5728\u5668\u5b98\u635f\u4f24\u76f8\u5173\u75be\u75c5\u6cbb\u7597\u4e2d\u7684\u5e94\u7528\u3002<\/p>\n<h3><span class=\"ez-toc-section\" id=\"01%E3%80%81%E8%82%9D%E6%8D%9F%E4%BC%A4%E4%BF%AE%E5%A4%8D\"><\/span>01\u3001\u809d\u635f\u4f24\u4fee\u590d<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09\u56e0\u5176\u5728\u809d\u635f\u4f24\u6cbb\u7597\u4e2d\u7684\u6f5c\u5728\u5e94\u7528\u800c\u65e5\u76ca\u53d7\u5230\u5173\u6ce8\u3002\u5b83\u4eec\u901a\u8fc7\u76f4\u63a5\u5206\u5316\u4e3a\u809d\u7ec6\u80de\u3001\u8c03\u8282\u708e\u75c7\u53cd\u5e94\u548c\u514d\u75ab\u529f\u80fd\uff0c\u5728\u809d\u810f\u518d\u751f\u4e2d\u53d1\u6325\u4f5c\u7528\u3002\u6b64\u5916\uff0c\u5b83\u4eec\u8fd8\u80fd\u6291\u5236\u809d\u661f\u72b6\u7ec6\u80de\u7684\u6d3b\u5316\uff0c\u4ece\u800c\u51cf\u5c11\u80f6\u539f\u86cb\u767d\u7684\u79ef\u7d2f\u5e76\u51cf\u8f7b\u809d\u7ea4\u7ef4\u5316\u3002MSCs\u8fd8\u6709\u52a9\u4e8e\u9632\u6b62\u809d\u7ec6\u80de\u7684\u9000\u5316\u548c\u574f\u6b7b\uff0c\u4ece\u800c\u7ef4\u6301\u7ec6\u80de\u7684\u5065\u5eb7\u548c\u5e73\u8861\u3002<\/p>\n<p>2025\u5e741\u67086\u53f7\uff0c\u4e2d\u56fd\u53f0\u6e7e\u53f0\u5317\u4e09\u519b\u603b\u533b\u9662\u56fd\u9632\u533b\u5b66\u9662\u5185\u79d1\u90e8\u80c3\u80a0\u79d1\u5728\u300aStem Cell Research&amp;Therapy\u300b\u4e0a\u53d1\u8868\u4e86\u4e00\u9879<a href=\"https:\/\/stemcellres.biomedcentral.com\/articles\/10.1186\/s13287-024-04127-y\" target=\"_blank\" rel=\"noopener nofollow\">\u201c\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u7597\u6cd5\u6709\u671b\u6210\u4e3a\u809d\u810f\u75be\u75c5\u6cbb\u7597\u7684\u7a81\u7834\u6027\u7597\u6cd5\uff1a\u5f53\u524d\u4e34\u5e8a\u8bd5\u9a8c\u7efc\u8ff0\u201d<\/a>\u7684\u6587\u7ae0\u3002<\/p>\n<div id=\"attachment_20582\" style=\"width: 769px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-20582\" class=\"wp-image-20582 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-20_151211_785.png\" alt=\"\" width=\"759\" height=\"407\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-20_151211_785.png 759w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-20_151211_785-300x161.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-20_151211_785-18x10.png 18w\" sizes=\"(max-width: 759px) 100vw, 759px\" \/><p id=\"caption-attachment-20582\" class=\"wp-caption-text\">\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u7597\u6cd5\u6709\u671b\u6210\u4e3a\u809d\u810f\u75be\u75c5\u6cbb\u7597\u7684\u7a81\u7834\u6027\u7597\u6cd5\uff1a\u5f53\u524d\u4e34\u5e8a\u8bd5\u9a8c\u7efc\u8ff0<\/p><\/div>\n<p>\u6587\u7ae0\u7ed3\u679c\u8868\u660e\uff1a\u6e90\u81ea\u9aa8\u9ad3\u548c\u8110\u5e26\u7684MSC\u5728\u9006\u8f6c\u809d\u635f\u4f24\u3001\u6539\u5584\u809d\u529f\u80fd\u65b9\u9762\u5c55\u73b0\u51fa\u663e\u8457\u7684\u6f5c\u529b\uff0c\u5e76\u4e3a\u5bf9\u4f20\u7edf\u7597\u6cd5\u65e0\u53cd\u5e94\u7684\u60a3\u8005\u5e26\u6765\u4e86\u5e0c\u671b\u3002\u901a\u8fc7\u809d\u9759\u8109\u3001\u95e8\u9759\u8109\u6216\u5916\u5468\u9759\u8109\u7ed9\u836f\uff0cMSC\u53ef\u663e\u8457\u6539\u5584\u809d\u810f\u7ec4\u7ec7\u5b66\uff0c\u51cf\u5c11\u7ea4\u7ef4\u5316\uff0c\u5e76\u6062\u590d\u809d\u810f\u529f\u80fd\u3002\u6b64\u5916\uff0cMSC\u884d\u751f\u7684\u7269\u8d28\uff0c\u4f8b\u5982\u7ec6\u80de\u5916\u56ca\u6ce1\u548c\u5916\u6ccc\u4f53\uff0c\u6b63\u9010\u6e10\u6210\u4e3a\u6cbb\u7597\u809d\u8870\u7aed\u548c\u51cf\u8f7b\u79fb\u690d\u540e\u5e76\u53d1\u75c7\u7684\u524d\u6cbf\u5de5\u5177\u3002<\/p>\n<h3><span class=\"ez-toc-section\" id=\"02%E3%80%81%E5%BF%83%E8%84%8F%E6%8D%9F%E4%BC%A4%E4%BF%AE%E5%A4%8D\"><\/span>02\u3001\u5fc3\u810f\u635f\u4f24\u4fee\u590d<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u5728\u6025\u6027\u5fc3\u808c\u6897\u6b7b\u3001\u5fc3\u529b\u8870\u7aed\u548c\u7f3a\u8840\u6027\u5fc3\u810f\u75c5\u7b49\u5e38\u89c1\u5fc3\u810f\u635f\u4f24\u4e2d\uff0c\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09\u901a\u8fc7\u6297\u708e\u8fc7\u7a0b\u51cf\u5c11\u53d7\u635f\u5fc3\u808c\u4e2d\u4fc3\u708e\u514d\u75ab\u7ec6\u80de\u7684\u6d78\u6da6\uff0c\u4ece\u800c\u53d1\u6325\u6cbb\u7597\u4f5c\u7528\u3002\u6b64\u5916\uff0c\u5b83\u4eec\u8fd8\u901a\u8fc7\u6297\u7ea4\u7ef4\u5316\u4f5c\u7528\u8c03\u8282\u7622\u75d5\u5f62\u6210\u548c\u5fc3\u808c\u4fee\u590d\uff0c\u5e76\u901a\u8fc7\u4fc3\u8fdb\u8840\u7ba1\u751f\u6210\u548c\u6291\u5236\u7ec6\u80de\u51cb\u4ea1\u7684\u673a\u5236\u4fc3\u8fdb\u5fc3\u810f\u518d\u751f\u3002<\/p>\n<p>2025\u5e7410\u67081\u53f7\uff0c\u300anature\u300b\u5b50\u520a\u201cexperimental&amp;molecular medicine\u201d\u53d1\u8868\u4e86\u4e00\u9879<a href=\"https:\/\/www.nature.com\/articles\/s12276-025-01549-3\" target=\"_blank\" rel=\"noopener nofollow\">\u201c\u5fc3\u810f\u4fee\u590d\u4e0e\u518d\u751f\uff1a\u7ec6\u80de\u7597\u6cd5\u3001\u4f53\u5185\u91cd\u7f16\u7a0b\u4ee5\u53ca\u7ec6\u80de\u5916\u56ca\u6ce1\u7684\u524d\u666f\u201d<\/a>\u7684\u7814\u7a76\u7efc\u8ff0\u3002<\/p>\n<section>\n<div id=\"attachment_20581\" style=\"width: 734px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-20581\" class=\"wp-image-20581 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-20_151228_888.png\" alt=\"\" width=\"724\" height=\"341\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-20_151228_888.png 724w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-20_151228_888-300x141.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-20_151228_888-18x8.png 18w\" sizes=\"(max-width: 724px) 100vw, 724px\" \/><p id=\"caption-attachment-20581\" class=\"wp-caption-text\">\u5fc3\u810f\u4fee\u590d\u4e0e\u518d\u751f\uff1a\u7ec6\u80de\u7597\u6cd5\u3001\u4f53\u5185\u91cd\u7f16\u7a0b\u4ee5\u53ca\u7ec6\u80de\u5916\u56ca\u6ce1\u7684\u524d\u666f<\/p><\/div>\n<\/section>\n<\/section>\n<section data-role=\"paragraph\" data-pm-slice=\"4 3 [&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;outer&quot;,&quot;class&quot;:&quot;article135&quot;,&quot;label&quot;:&quot;edit by 135editor&quot;,&quot;data-pm-slice&quot;:&quot;0 0 []&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;}]\">\u7efc\u8ff0\u8868\u660e\u5927\u591a\u6570\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6765\u6e90\u7684\u7ec6\u80de\u5916\u56ca\u6ce1\uff08Stem-EVs\uff09\u4e0d\u5177\u6709\u514d\u75ab\u539f\u6027\uff0c\u5e76\u643a\u5e26\u5fc3\u810f\u4fdd\u62a4\u6027\u6cbb\u7597\u8f7d\u8377\u3002\u6b64\u5916\uff0c\u5728\u6025\u6027\u5fc3\u808c\u6897\u6b7b\u52a8\u7269\u6a21\u578b\u4e2d\uff0c\u7ed9\u4e88\u591a\u79cd\u7c7b\u578b\u7684\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u5916\u6ccc\u4f53\u53ef\u51cf\u5c11\u708e\u75c7\u548c\u7ec6\u80de\u51cb\u4ea1\uff0c\u7f29\u5c0f\u6897\u6b7b\u9762\u79ef\u5e76\u6539\u5584\u5fc3\u810f\u529f\u80fd\u3002<\/p>\n<h3><span class=\"ez-toc-section\" id=\"03%E3%80%81%E8%82%BA%E6%8D%9F%E4%BC%A4%E4%BF%AE%E5%A4%8D\"><\/span>03\u3001\u80ba\u635f\u4f24\u4fee\u590d<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u80ba\u635f\u4f24\u5e38\u89c1\u4e8e\u6025\u6027\u611f\u67d3\u5f15\u8d77\u7684\u80ba\u90e8\u708e\u75c7\u548c\u5faa\u73af\u7cfb\u7edf\u957f\u671f\u635f\u4f24\u5bfc\u81f4\u7684\u80ba\u7ea4\u7ef4\u5316\u7b49\u60c5\u51b5\u3002\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09\u80fd\u591f\u901a\u8fc7\u7ec6\u80de\u95f4\u7684\u76f4\u63a5\u76f8\u4e92\u4f5c\u7528\u548c\u65c1\u5206\u6ccc\u4fe1\u53f7\u8c03\u8282\u4e0d\u540c\u7684\u514d\u75ab\u53cd\u5e94\uff0c\u4ece\u800c\u53d1\u6325\u6297\u708e\u4f5c\u7528\u5e76\u5f71\u54cd\u80ba\u7ea4\u7ef4\u5316\u7684\u8fdb\u5c55\u3002\u6b64\u5916\uff0cMSCs\u8fd8\u80fd\u4fc3\u8fdb\u65b0\u8840\u7ba1\u7684\u5f62\u6210\u3001\u652f\u6301\u7ec6\u80de\u529f\u80fd\u5e76\u51cf\u5c11\u7ec6\u80de\u6b7b\u4ea1\uff0c\u6700\u7ec8\u6709\u52a9\u4e8e\u7ef4\u6301\u547c\u5438\u529f\u80fd\u548c\u8f85\u52a9\u7ec4\u7ec7\u4fee\u590d\u3002<\/p>\n<p>2025\u5e749\u67085\u65e5\uff0c\u6d59\u6c5f\u4e2d\u533b\u836f\u5927\u5b66\u9644\u5c5e\u7b2c\u4e00\u533b\u9662\uff08\u6d59\u6c5f\u7701\u4e2d\u533b\u9662\uff09\u8001\u5e74\u533b\u5b66\u79d1\u5728\u300anature\u300b\u5b50\u520a\u201ccell death discovery\u201d\u4e0a\u53d1\u8868\u4e86\u4e00\u9879<a class=\"normal_text_link mp_article_text_link\" href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzkwOTEzMDY0Nw==&amp;mid=2247516517&amp;idx=1&amp;sn=4ffa5315a22d2921d09dcb2f778381ed&amp;scene=21#wechat_redirect\" target=\"_blank\" rel=\"noopener nofollow\" data-itemshowtype=\"0\" data-linktype=\"2\">\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6cbb\u7597\u80ba\u90e8\u75be\u75c5\uff1a\u805a\u7126\u514d\u75ab\u8c03\u8282\u4f5c\u7528<\/a>\u7684\u7814\u7a76\u7efc\u8ff0\u3002<\/p>\n<section>\n<div id=\"attachment_20580\" style=\"width: 744px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-20580\" class=\"wp-image-20580 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-20_151519_232.png\" alt=\"\" width=\"734\" height=\"421\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-20_151519_232.png 734w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-20_151519_232-300x172.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-20_151519_232-18x10.png 18w\" sizes=\"(max-width: 734px) 100vw, 734px\" \/><p id=\"caption-attachment-20580\" class=\"wp-caption-text\">\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6cbb\u7597\u80ba\u90e8\u75be\u75c5\uff1a\u805a\u7126\u514d\u75ab\u8c03\u8282\u4f5c\u7528<\/p><\/div>\n<\/section>\n<\/section>\n<section data-role=\"paragraph\" data-pm-slice=\"4 3 [&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;outer&quot;,&quot;class&quot;:&quot;article135&quot;,&quot;label&quot;:&quot;edit by 135editor&quot;,&quot;data-pm-slice&quot;:&quot;0 0 []&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;}]\">\u7efc\u8ff0\u521d\u6b65\u7ed3\u679c\u8868\u660e\uff1a\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09\u56e0\u5176\u5f3a\u5927\u7684\u6297\u708e\u3001\u6297\u51cb\u4ea1\u548c\u7ec4\u7ec7\u518d\u751f\u7279\u6027\uff0c\u5df2\u88ab\u7528\u4e8e\u6cbb\u7597\u591a\u79cd\u708e\u75c7\u6027\u75be\u75c5\u3002MSCs\u5c55\u73b0\u51fa\u5de8\u5927\u7684\u6f5c\u529b\uff0c\u5e76\u5728\u5b9e\u9a8c\u4e2d\u88ab\u8bc1\u5b9e\u80fd\u591f\u7f13\u89e3\u80ba\u90e8\u75be\u75c5\u3002MSCs\u7684\u514d\u75ab\u8c03\u8282\u4f5c\u7528\u88ab\u8ba4\u4e3a\u662f\u5176\u591a\u79cd\u6f5c\u5728\u6cbb\u7597\u6548\u679c\u7684\u5173\u952e\u673a\u5236\u3002<\/p>\n<h3><span class=\"ez-toc-section\" id=\"04%E3%80%81%E8%82%BE%E6%8D%9F%E4%BC%A4\"><\/span>04\u3001\u80be\u635f\u4f24<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09\u5177\u6709\u663e\u8457\u7684\u514d\u75ab\u8c03\u8282\u548c\u7ec4\u7ec7\u518d\u751f\u80fd\u529b\uff0c\u4f7f\u5176\u6210\u4e3a\u80be\u810f\u75be\u75c5\u6cbb\u7597\u7684\u7406\u60f3\u5019\u9009\u7ec6\u80de\u3002\u8fd9\u4e9b\u7ec6\u80de\u901a\u8fc7\u91ca\u653e\u591a\u79cd\u6297\u708e\u7269\u8d28\u6765\u5f71\u54cd\u514d\u75ab\u53cd\u5e94\uff0c\u4ece\u800c\u6539\u5584\u80be\u810f\u7ec4\u7ec7\u7684\u514d\u75ab\u73af\u5883\u3002\u6b64\u5916\uff0cMSCs\u8fd8\u80fd\u591f\u6fc0\u6d3b\u6216\u6291\u5236\u7279\u5b9a\u7684\u4fe1\u53f7\u901a\u8def\uff0c\u8fd9\u4e9b\u901a\u8def\u6709\u52a9\u4e8e\u51cf\u5c11\u80be\u810f\u7ec4\u7ec7\u4e2d\u7684\u80f6\u539f\u86cb\u767d\u6c89\u79ef\uff0c\u51cf\u8f7b\u80be\u7ea4\u7ef4\u5316\uff0c\u901a\u8fc7\u8840\u7ba1\u751f\u6210\u4fc3\u8fdb\u80be\u810f\u8840\u6db2\u5faa\u73af\uff0c\u5e76\u652f\u6301\u80be\u5b9e\u8d28\u7ec6\u80de\u7684\u751f\u957f\u548c\u5b58\u6d3b\u3002<\/p>\n<p>2025\u5e743\u67083\u65e5\uff0c\u4e2d\u56fd\u9655\u897f\u7701\u897f\u5b89\u5e02\u7a7a\u519b\u519b\u533b\u5927\u5b66\u897f\u4eac\u533b\u9662\u80be\u5185\u79d1\u5728\u671f\u520a\u6742\u5fd7\u300aBMC\u80be\u810f\u75c5\u5b66\u300b\u4e0a\u53d1\u8868\u4e86\u4e00\u9879<a href=\"https:\/\/bmcnephrol.biomedcentral.com\/articles\/10.1186\/s12882-025-04029-y\" target=\"_blank\" rel=\"noopener nofollow\">\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u7597\u6cd5\u5728\u6162\u6027\u80be\u810f\u75c5\u4e2d\u7684\u514d\u75ab\u8c03\u8282\u4f5c\u7528\uff1a\u6587\u732e\u7efc\u8ff0<\/a>The<\/p>\n<section>\n<div id=\"attachment_20579\" style=\"width: 770px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-20579\" class=\"wp-image-20579 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-20_151600_561.png\" alt=\"\" width=\"760\" height=\"391\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-20_151600_561.png 760w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-20_151600_561-300x154.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-20_151600_561-18x9.png 18w\" sizes=\"(max-width: 760px) 100vw, 760px\" \/><p id=\"caption-attachment-20579\" class=\"wp-caption-text\">\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u7597\u6cd5\u5728\u6162\u6027\u80be\u810f\u75c5\u4e2d\u7684\u514d\u75ab\u8c03\u8282\u4f5c\u7528\uff1a\u6587\u732e\u7efc\u8ff0<\/p><\/div>\n<\/section>\n<p>\u7efc\u8ff0\u7ed3\u679c\u8868\u660e\uff1a\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSC\uff09\u8f93\u6ce8\u6cbb\u7597\u6162\u6027\u80be\u810f\u75c5\uff08CKD\uff09\u5df2\u8bc1\u5b9e\u5177\u6709\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u65e2\u5f80\u8bd5\u9a8c\u4e5f\u652f\u6301\u8be5\u7ec6\u80de\u7597\u6cd5\u5bf9CKD\u60a3\u8005\u7684\u53ef\u884c\u6027\u3002\u72fc\u75ae\u6027\u80be\u708e\uff08LN\uff09\u60a3\u8005\u66f4\u5bb9\u6613\u83b7\u5f97\u7f13\u89e3\uff0c\u80be\u529f\u80fd\u4e5f\u5f97\u5230\u6539\u5584\uff0c\u5305\u62ec\u5c3f\u86cb\u767d\u3001\u8840\u6e05\u808c\u9150\uff08SCr\uff09\u548c\u5c3f\u7d20\u6c2e\uff08BUN\uff09\u6c34\u5e73\u7684\u964d\u4f4e\uff0c\u8fd9\u4e0e\u4e34\u5e8a\u524d\u7814\u7a76\u7ed3\u679c\u4e00\u81f4\u3002<\/p>\n<p>MSC\u6cbb\u7597\u8fd8\u663e\u793a\u51fa\u6539\u5584\u7cd6\u5c3f\u75c5\u80be\u75c5\uff08DN\uff09\u60a3\u8005\u80be\u5c0f\u7403\u6ee4\u8fc7\u7387\uff08GFR\uff09\u7684\u80fd\u529b\u3002\u5728\u80be\u810f\u75be\u75c5\u60a3\u8005\u4e2d\uff0cMSC\u7597\u6cd5\u53ef\u901a\u8fc7\u4fc3\u8fdb\u8c03\u8282\u6027T\u7ec6\u80de\uff08Treg\uff09\u7684\u589e\u6b96\u548c\u6291\u5236\u9002\u5e94\u6027\u514d\u75ab\u6765\u6291\u5236\u8fc7\u5ea6\u6d3b\u8dc3\u7684\u514d\u75ab\u53cd\u5e94\u3002<\/p>\n<h3><span class=\"ez-toc-section\" id=\"05%E3%80%81%E7%A5%9E%E7%BB%8F%E7%B3%BB%E7%BB%9F%E6%8D%9F%E4%BC%A4\"><\/span>05\u3001\u795e\u7ecf\u7cfb\u7edf\u635f\u4f24<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09\u901a\u8fc7\u591a\u79cd\u673a\u5236\u5728\u4fc3\u8fdb\u795e\u7ecf\u529f\u80fd\u91cd\u5efa\u65b9\u9762\u5c55\u73b0\u51fa\u5de8\u5927\u7684\u6f5c\u529b\u3002\u8fd9\u4e9b\u673a\u5236\u5305\u62ec\u4fc3\u8fdb\u795e\u7ecf\u5206\u5316\u3001\u51cf\u5c11\u795e\u7ecf\u708e\u75c7\u56e0\u5b50\u7684\u6d78\u6da6\u3001\u901a\u8fc7\u8840\u7ba1\u751f\u6210\u6539\u5584\u5fae\u73af\u5883\u4ee5\u53ca\u901a\u8fc7\u964d\u4f4e\u7ec6\u80de\u51cb\u4ea1\u6c34\u5e73\u6765\u51cf\u5c11\u635f\u4f24\u3002\u91cd\u8981\u7684\u662f\uff0cMSCs\u91ca\u653e\u7684\u5916\u6ccc\u4f53\u80fd\u591f\u7a7f\u8fc7\u8840\u8111\u5c4f\u969c\uff0c\u4ece\u800c\u5b9e\u73b0\u65e0\u9700\u514d\u75ab\u6291\u5236\u5373\u53ef\u5b89\u5168\u9012\u9001\u3002<\/p>\n<ul class=\"list-paddingleft-1\">\n<li><a class=\"normal_text_link mp_article_text_link\" href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzkwOTEzMDY0Nw==&amp;mid=2247515235&amp;idx=1&amp;sn=8225533c10ac9f6ac6c1a08135ddf723&amp;scene=21#wechat_redirect\" target=\"_blank\" rel=\"noopener nofollow\" data-itemshowtype=\"0\" data-linktype=\"2\">\u795e\u7ecf\u4fee\u590d\u65b0\u7eaa\u5143\uff1a\u5e72\u7ec6\u80de\u7684\u591a\u9776\u70b9\u673a\u5236\u4e0e\u516d\u5927\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u7684\u4e34\u5e8a\u8f6c\u5316\u8fdb\u5c55<\/a><\/li>\n<\/ul>\n<p>2024\u5e7411\u670822\u65e5\uff0c\u671f\u520a\u6742\u5fd7\u300aJournal of Translational Medicine\u300b\u53d1\u8868\u4e86\u4e00\u7bc7<a href=\"https:\/\/translational-medicine.biomedcentral.com\/articles\/10.1186\/s12967-024-05725-3\" target=\"_blank\" rel=\"noopener nofollow\">\u201c\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u7597\u6cd5\u6cbb\u7597\u521b\u4f24\u6027\u795e\u7ecf\u635f\u4f24\u201d<\/a>\u7684\u7814\u7a76\u7efc\u8ff0\u3002<\/p>\n<section>\n<div id=\"attachment_20578\" style=\"width: 771px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-20578\" class=\"wp-image-20578 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-20_151651_297.png\" alt=\"\" width=\"761\" height=\"391\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-20_151651_297.png 761w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-20_151651_297-300x154.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-20_151651_297-18x9.png 18w\" sizes=\"(max-width: 761px) 100vw, 761px\" \/><p id=\"caption-attachment-20578\" class=\"wp-caption-text\">\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u7597\u6cd5\u6cbb\u7597\u521b\u4f24\u6027\u795e\u7ecf\u635f\u4f24<\/p><\/div>\n<\/section>\n<p>\u7efc\u8ff0\u8868\u660e\uff1a\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSC\uff09\u7597\u6cd5\u5728\u6539\u5584\u521b\u4f24\u6027\u795e\u7ecf\u635f\u4f24\u60a3\u8005\u7684\u9884\u540e\u65b9\u9762\u5177\u6709\u4ee4\u4eba\u632f\u594b\u7684\u6f5c\u529b\u3002\u5c3d\u7ba1\u6211\u4eec\u5bf9MSC\u5728\u795e\u7ecf\u635f\u4f24\u5fae\u73af\u5883\u4e2d\u7684\u529f\u80fd\u7279\u6027\u5c1a\u672a\u5b8c\u5168\u4e86\u89e3\uff0c\u4f46\u7814\u7a76\u4eba\u5458\u5df2\u4ed8\u51fa\u5de8\u5927\u7684\u52aa\u529b\u6765\u6316\u6398MSC\u7597\u6cd5\u7684\u6f5c\u529b\u3002<\/p>\n<h3><span class=\"ez-toc-section\" id=\"%E9%97%B4%E5%85%85%E8%B4%A8%E5%B9%B2%E7%BB%86%E8%83%9E%E7%9A%84%E6%9C%BA%E5%88%B6%E6%A6%82%E8%BF%B0\"><\/span>\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u7684\u673a\u5236\u6982\u8ff0<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09\u5728\u591a\u79cd\u7ec4\u7ec7\u548c\u5668\u5b98\u7684\u518d\u751f\u4e0e\u4fee\u590d\u65b9\u9762\u5c55\u73b0\u51fa\u5de8\u5927\u7684\u6f5c\u529b\u3002\u5176\u6cbb\u7597\u4f5c\u7528\u4e3b\u8981\u6e90\u4e8e\u65c1\u5206\u6ccc\u673a\u5236\uff0c\u8be5\u673a\u5236\u6d89\u53ca\u5206\u6ccc\u4e00\u7cfb\u5217\u7ec6\u80de\u56e0\u5b50\u548c\u7ec6\u80de\u5916\u56ca\u6ce1\uff08EVs\uff09\uff0c\u8fd9\u4e9b\u56e0\u5b50\u548c\u56ca\u6ce1\u53d1\u6325\u591a\u79cd\u751f\u7269\u5b66\u6548\u5e94\uff0c\u5305\u62ec\u6291\u5236\u7ea4\u7ef4\u5316\u3001\u51cf\u8f7b\u708e\u75c7\u3001\u51cf\u5c11\u7ec6\u80de\u51cb\u4ea1\u548c\u4fc3\u8fdb\u8840\u7ba1\u751f\u6210\uff08\u89c1\u56fe3\uff09\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0cMSCs\u80fd\u591f\u4ea7\u751f\u5927\u91cf\u5bcc\u542b\u5c0fRNA\u7684\u5916\u6ccc\u4f53\uff0c\u8fd9\u4e9b\u5916\u6ccc\u4f53\u5bf9\u4e8e\u635f\u4f24\u540e\u7684\u7ec4\u7ec7\u4fee\u590d\u81f3\u5173\u91cd\u8981\u3002<\/p>\n<div id=\"attachment_20572\" style=\"width: 560px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-20572\" class=\"wp-image-20572 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5fae\u4fe1\u56fe\u7247_2025-11-19_181303_886.png\" alt=\"\" width=\"550\" height=\"311\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5fae\u4fe1\u56fe\u7247_2025-11-19_181303_886.png 550w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5fae\u4fe1\u56fe\u7247_2025-11-19_181303_886-300x170.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5fae\u4fe1\u56fe\u7247_2025-11-19_181303_886-18x10.png 18w\" sizes=\"(max-width: 550px) 100vw, 550px\" \/><p id=\"caption-attachment-20572\" 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class=\"ez-toc-section\" id=\"04%E3%80%81%E9%97%B4%E5%85%85%E8%B4%A8%E5%B9%B2%E7%BB%86%E8%83%9E%EF%BC%88MSCs%EF%BC%89%E7%9A%84%E6%B2%BB%E7%96%97%E6%95%88%E6%9E%9C%E5%92%8C%E5%AE%89%E5%85%A8%E6%80%A7\"><\/span>04\u3001\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09\u7684\u6cbb\u7597\u6548\u679c\u548c\u5b89\u5168\u6027<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><strong>\u4e00\u3001\u5728\u591a\u79cd\u75be\u75c5\u4e2d\u5c55\u73b0\u51fa\u663e\u8457\u7684\u6cbb\u7597\u6548\u679c\uff1a<\/strong>\u4e34\u5e8a\u8bd5\u9a8c\u8868\u660e\uff0c\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u5bf9\u4e0d\u540c\u7ec4\u7ec7\u7684\u635f\u4f24\u4fee\u590d\u5747\u6709\u79ef\u6781\u6548\u679c\u3002<\/p>\n<section data-role=\"list\">\n<ul 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class=\"ez-toc-section\" id=\"%E4%BA%94%E3%80%81%E7%BB%93%E8%AE%BA%E4%B8%8E%E5%B1%95%E6%9C%9B\"><\/span><strong>\u4e94\u3001\u7ed3\u8bba\u4e0e\u5c55\u671b<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p data-pm-slice=\"0 0 []\">\u7efc\u4e0a\u6240\u8ff0\uff0c\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09\u901a\u8fc7\u5176\u591a\u5411\u5206\u5316\u6f5c\u80fd\u3001\u514d\u75ab\u8c03\u8282\u3001\u65c1\u5206\u6ccc\u6548\u5e94\u53ca\u7ebf\u7c92\u4f53\u8f6c\u79fb\u7b49\u591a\u91cd\u673a\u5236\uff0c\u5728\u591a\u79cd\u91cd\u8981\u5668\u5b98\u635f\u4f24\u4fee\u590d\u4e2d\u5c55\u73b0\u51fa\u6838\u5fc3\u6cbb\u7597\u4ef7\u503c\u3002\u5176\u4f4e\u514d\u75ab\u539f\u6027\u7684\u7279\u70b9\uff0c\u8fdb\u4e00\u6b65\u4e3a\u5176\u5f02\u4f53\u5e94\u7528\u7684\u4e34\u5e8a\u8f6c\u5316\u63d0\u4f9b\u4e86\u663e\u8457\u4f18\u52bf\u3002<\/p>\n<p>\u5f53\u524d\uff0c\u5927\u91cf\u4e34\u5e8a\u8bd5\u9a8c\u5df2\u521d\u6b65\u9a8c\u8bc1\u4e86MSCs\u53ca\u5176\u6d3b\u6027\u6210\u5206\uff08\u5982\u5916\u6ccc\u4f53\uff09\u5728\u7ec4\u7ec7\u518d\u751f\u4e0e\u4fee\u590d\u4e2d\u7684\u5b89\u5168\u6027\u4e0e\u6709\u6548\u6027\uff0c\u6807\u5fd7\u7740\u7ec6\u80de\u6cbb\u7597\u6b63\u4ece\u7406\u8bba\u8d70\u5411\u5b9e\u8df5\u3002\u5c24\u5176\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u57fa\u4e8e\u5916\u6ccc\u4f53\u6216\u5de5\u7a0b\u5316MSCs\u7684\u9776\u5411\u9012\u9001\u7b56\u7565\uff0c\u6b63\u4e3a\u518d\u751f\u533b\u5b66\u7684\u7cbe\u51c6\u6cbb\u7597\u5f00\u542f\u65b0\u7684\u7bc7\u7ae0\u3002<\/p>\n<p>\u7136\u800c\uff0c\u5b9e\u73b0\u5176\u5168\u9762\u4e34\u5e8a\u5e94\u7528\u4ecd\u9762\u4e34\u4e09\u5927\u6838\u5fc3\u6311\u6218\uff1a<strong>\u7a33\u5b9a\u7684\u7ec6\u80de\/\u5916\u6ccc\u4f53\u6765\u6e90\u4e0e\u8d28\u63a7\u4f53\u7cfb\u3001\u7cbe\u51c6\u9ad8\u6548\u7684\u4f53\u5185\u9776\u5411\u9012\u9001\u6280\u672f\u3001\u4ee5\u53ca\u4f53\u5185\u5b58\u6d3b\u7387\u4e0e\u529f\u80fd\u6301\u4e45\u6027\u7684\u63d0\u5347<\/strong>\u3002\u8fd9\u4e9b\u95ee\u9898\u7684\u89e3\u51b3\uff0c\u6709\u8d56\u4e8e\u5728\u7ec6\u80de\u5236\u5907\u5de5\u827a\u3001\u9012\u9001\u7cfb\u7edf\u8bbe\u8ba1\u4e0e\u751f\u7269\u6750\u6599\u7b49\u9886\u57df\u5b9e\u73b0\u8de8\u5b66\u79d1\u7a81\u7834\u3002<\/p>\n<p>\u5c55\u671b\u672a\u6765\uff0c\u968f\u7740\u5bf9MSCs\u4f5c\u7528\u673a\u5236\u7684\u6df1\u5165\u89e3\u6790\u548c\u5de5\u7a0b\u5316\u6280\u672f\u7684\u65e5\u76ca\u6210\u719f\uff0c\u6211\u4eec\u6709\u7406\u7531\u76f8\u4fe1\uff0c\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u7597\u6cd5\u5fc5\u5c06\u8d85\u8d8a\u73b0\u6709\u7684\u4fee\u590d\u8303\u5f0f\uff0c\u4e3a\u653b\u514b\u96be\u6cbb\u6027\u7ec4\u7ec7\u635f\u4f24\u4e0e\u9000\u884c\u6027\u75be\u75c5\u63d0\u4f9b\u9769\u547d\u6027\u7684\u6cbb\u7597\u7b56\u7565\u3002<\/p>\n<\/section>\n<\/section>\n<p>References:<\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">[1] <\/span><\/span><span data-pm-slice=\"0 0 []\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">Bao L, Wang Z, Li L, Tang S, Zhao G, Zhang H, Zhang X. \u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u5728\u91cd\u8981\u5668\u5b98\u635f\u4f24\u4fee\u590d\u4e2d\u7684\u4f5c\u7528\uff1a\u4ece\u673a\u5236\u5230\u4e34\u5e8a\u5e94\u7528. Am J Stem Cells. 2025\u5e746\u670815\u65e5;14(2):53-72. doi: 10.62347\/YGXA7976. PMID: 40686745; PMCID: PMC12267123.<\/span><\/span><\/span><\/p>\n<p>Disclaimer: This article is intended only to disseminate scientific knowledge and share industry perspectives, and does not constitute any clinical diagnostic advice! The information published by Hangi Stem Cells is not a substitute for the professional advice of a physician or pharmacist. If you have any questions about copyright or other issues, please feel free to contact me.<\/p>","protected":false},"excerpt":{"rendered":"<p>\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09\u4f5c\u4e3a\u4e00\u7c7b\u8d77\u6e90\u4e8e\u4e2d\u80da\u5c42\u7684\u591a\u80fd\u5e72\u7ec6\u80de\uff0c\u56e0\u5176\u5353\u8d8a\u7684\u7ec4\u7ec7\u4fee\u590d\u80fd\u529b\u800c\u6210\u4e3a\u518d\u751f\u533b\u5b66\u7684\u7126\u70b9\u3002\u5176\u4fee\u590d\u6f5c [&hellip;]<\/p>","protected":false},"author":1,"featured_media":20577,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[61],"tags":[],"_links":{"self":[{"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/posts\/20576"}],"collection":[{"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/comments?post=20576"}],"version-history":[{"count":2,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/posts\/20576\/revisions"}],"predecessor-version":[{"id":20588,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/posts\/20576\/revisions\/20588"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/media\/20577"}],"wp:attachment":[{"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/media?parent=20576"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/categories?post=20576"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/tags?post=20576"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}