{"id":20596,"date":"2025-11-20T17:50:30","date_gmt":"2025-11-20T09:50:30","guid":{"rendered":"https:\/\/www.hjtdsm.cn\/?p=20596"},"modified":"2025-11-20T17:50:54","modified_gmt":"2025-11-20T09:50:54","slug":"https-www-hjtdsm-cn-stem-cells-mscs-20596-html","status":"publish","type":"post","link":"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/mscs\/20596.html","title":{"rendered":"\u4eba\u8110\u5e26\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff1a\u518d\u751f\u533b\u5b66\u7684\u5e0c\u671b"},"content":{"rendered":"<p><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u51e0\u5341\u5e74\u524d\uff0c\u5e72\u7ec6\u80de\u7684\u53d1\u73b0\u56e0\u5176\u518d\u751f\u6f5c\u80fd\u800c\u5e26\u6765\u4e86\u5e0c\u671b\u3002\u79d1\u5b66\u5bb6\u4eec\u6295\u8eab\u4e8e\u5e72\u7ec6\u80de\u7814\u7a76\uff0c\u81f4\u529b\u4e8e\u5f00\u53d1\u9488\u5bf9\u5404\u79cd\u75be\u75c5\u7684\u7597\u6cd5\u3002\u968f\u7740<a href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/mscs\/20576.html\/\" target=\"_blank\" rel=\"noopener\">\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09<\/a>\u6f5c\u80fd\u7684\u63ed\u793a\uff0c\u5bfb\u627e\u4e0d\u540c\u5e72\u7ec6\u80de\u6765\u6e90\u7684\u65b0\u9014\u5f84\u4e5f\u968f\u4e4b\u5f00\u8f9f\u3002\u7531\u4e8e\u5176\u8bf8\u591a\u4f18\u52bf\uff0c\u4eba\u8110\u5e26\u6210\u4e3a\u63d0\u53d6MSCs\u7684\u9996\u9009\u3002\u5c3d\u7ba1\u5176\u5728\u6cbb\u7597\u4e2d\u7684\u5e94\u7528\u4ecd\u5728\u7814\u7a76\u4e2d\uff0c\u4f46\u672c\u6587\u5c06\u91cd\u70b9\u4ecb\u7ecd\u4eba<\/span><\/span><\/span><strong><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8110\u5e26\u6765\u6e90\u95f4\u5145\u8d28\u5e72\u7ec6\u80de<\/span><\/span><\/span><\/strong><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff08hUC-MSCs\uff09\u7684\u4f18\u52bf\u3001\u76ca\u5904\u548c\u5e94\u7528\u3002<\/span><\/span><\/span><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-20597 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/istockphoto-1316439704-612x612-1.jpg\" alt=\"\u4eba\u8110\u5e26\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff1a\u518d\u751f\u533b\u5b66\u7684\u5e0c\u671b\" width=\"612\" height=\"408\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/istockphoto-1316439704-612x612-1.jpg 612w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/istockphoto-1316439704-612x612-1-300x200.jpg 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/istockphoto-1316439704-612x612-1-18x12.jpg 18w\" sizes=\"(max-width: 612px) 100vw, 612px\" \/><\/p>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_79_2 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewbox=\"0 0 24 24\" version=\"1.2\" baseprofile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/mscs\/20596.html\/#%E4%BA%BA%E8%84%90%E5%B8%A6%E9%97%B4%E5%85%85%E8%B4%A8%E5%B9%B2%E7%BB%86%E8%83%9E\" >\u4eba\u8110\u5e26\u95f4\u5145\u8d28\u5e72\u7ec6\u80de<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/mscs\/20596.html\/#%E7%94%9F%E7%89%A9%E5%AD%A6%E7%89%B9%E5%BE%81\" >\u751f\u7269\u5b66\u7279\u5f81<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-3\" 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href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/mscs\/20596.html\/#%E5%B8%B8%E8%A7%81%E9%97%AE%E9%A2%98%E8%A7%A3%E7%AD%94\" >\u5e38\u89c1\u95ee\u9898\u89e3\u7b54<\/a><ul class='ez-toc-list-level-4' ><li class='ez-toc-heading-level-4'><ul class='ez-toc-list-level-4' ><li class='ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/mscs\/20596.html\/#%E9%97%AE%EF%BC%9A%E4%BA%BA%E8%84%90%E5%B8%A6%E9%97%B4%E5%85%85%E8%B4%A8%E5%B9%B2%E7%BB%86%E8%83%9E%EF%BC%88MSCs%EF%BC%89%E4%B8%8E%E5%85%B6%E4%BB%96%E6%9D%A5%E6%BA%90%E7%9A%84%E9%97%B4%E5%85%85%E8%B4%A8%E5%B9%B2%E7%BB%86%E8%83%9E%E7%9B%B8%E6%AF%94%E6%9C%89%E5%93%AA%E4%BA%9B%E4%BC%98%E5%8A%BF%EF%BC%9F\" >\u95ee\uff1a\u4eba\u8110\u5e26\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09\u4e0e\u5176\u4ed6\u6765\u6e90\u7684\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u76f8\u6bd4\u6709\u54ea\u4e9b\u4f18\u52bf\uff1f<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/mscs\/20596.html\/#%E9%97%AE%EF%BC%9AhUC-MSCs%E7%9A%84%E6%B2%BB%E7%96%97%E7%89%B9%E6%80%A7%E6%98%AF%E4%BB%80%E4%B9%88%EF%BC%9F\" >\u95ee\uff1ahUC-MSCs\u7684\u6cbb\u7597\u7279\u6027\u662f\u4ec0\u4e48\uff1f<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/mscs\/20596.html\/#%E9%97%AE%EF%BC%9AhUC-MSCs%E6%98%AF%E5%A6%82%E4%BD%95%E6%8A%91%E5%88%B6%E5%85%8D%E7%96%AB%E7%B3%BB%E7%BB%9F%E7%9A%84%EF%BC%9F\" >\u95ee\uff1ahUC-MSCs\u662f\u5982\u4f55\u6291\u5236\u514d\u75ab\u7cfb\u7edf\u7684\uff1f<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/mscs\/20596.html\/#%E9%97%AE%EF%BC%9AhUC-MSCs%E7%94%A8%E4%BA%8E%E6%B2%BB%E7%96%97%E5%BA%94%E7%94%A8%E6%98%AF%E5%90%A6%E5%AE%89%E5%85%A8%EF%BC%9F\" >\u95ee\uff1ahUC-MSCs\u7528\u4e8e\u6cbb\u7597\u5e94\u7528\u662f\u5426\u5b89\u5168\uff1f<\/a><\/li><\/ul><\/li><\/ul><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"%E4%BA%BA%E8%84%90%E5%B8%A6%E9%97%B4%E5%85%85%E8%B4%A8%E5%B9%B2%E7%BB%86%E8%83%9E\"><\/span><b><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4eba\u8110\u5e26\u95f4\u5145\u8d28\u5e72\u7ec6\u80de<\/span><\/span><\/span><\/b><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09\u8d77\u6e90\u4e8e\u4e2d\u80da\u5c42\uff0c\u5177\u6709\u591a\u5411\u5206\u5316\u6f5c\u80fd\u3002\u867d\u7136\u6700\u521d\u662f\u4ece\u9aa8\u9ad3\u4e2d\u63d0\u53d6\u7684\uff0c\u4f46\u968f\u7740\u65f6\u95f4\u7684\u63a8\u79fb\uff0c\u5176\u4ed6\u6765\u6e90\u4e5f\u9010\u6e10\u88ab\u53d1\u73b0\uff0c\u5305\u62ec\u7259\u9ad3\u3001\u8102\u80aa\u7ec4\u7ec7\u548c\u8110\u5e26\u3002\u5229\u7528\u8110\u5e26\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u8fdb\u884c\u6cbb\u7597\u7684\u4f18\u52bf\u5982\u4e0b\uff1a<\/span><\/span><\/span><\/p>\n<p><b><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6548\u529b\uff1a<\/span><\/span><\/span><\/b><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5e72\u7ec6\u80de\u7684\u6548\u529b\u4f1a\u968f\u7740\u5e74\u9f84\u589e\u957f\u800c\u964d\u4f4e\uff0c\u4ece\u800c\u9650\u5236\u4e86\u6e90\u81ea\u6210\u4eba\u7ec4\u7ec7\u7684\u5e72\u7ec6\u80de\u7684\u6cbb\u7597\u6f5c\u529b\u3002<a href=\"https:\/\/stemcellres.biomedcentral.com\/articles\/10.1186\/s13287-021-02222-y\" target=\"_blank\" rel=\"noopener nofollow\">\u4eba\u8110\u5e26\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08hUC-MSCs\uff09<\/a>\u4e0d\u53d7\u5e74\u9f84\u5f71\u54cd\uff0c\u56e0\u6b64\u4fdd\u6301\u4e86\u5176\u6548\u529b\u3002\u8bb8\u591a\u7814\u7a76\u8bc1\u5b9e\u4e86\u5176\u66f4\u9ad8\u7684\u518d\u751f\u6f5c\u80fd\u3002\u5b83\u4eec\u7684\u8868\u8fbe\u8c31\u4e0e\u80da\u80ce\u5e72\u7ec6\u80de\u76f8\u4f3c\uff0c\u4f46\u7531\u4e8e\u4f26\u7406\u95ee\u9898\uff0c\u80da\u80ce\u5e72\u7ec6\u80de\u5df2\u88ab\u7981\u7528\u3002\u56e0\u6b64\uff0c\u5b83\u4eec\u7684\u6f5c\u529b\u4ecb\u4e8e\u80da\u80ce\u5e72\u7ec6\u80de\u548c\u6210\u4eba\u7ec4\u7ec7\u5e72\u7ec6\u80de\u4e4b\u95f4\u3002<\/span><\/span><\/span><\/p>\n<p><b><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u514d\u75ab\u539f\u6027\uff1a<\/span><\/span><\/span><\/b><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8110\u5e26\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u7684HLA\u6807\u5fd7\u7269\u542b\u91cf\u4e5f\u8f83\u4f4e\uff0c\u800cHLA\u6807\u5fd7\u7269\u662f\u5bfc\u81f4\u79fb\u690d\u7269\u6297\u5bbf\u4e3b\u75c5\u548c\u514d\u75ab\u6392\u65a5\u53cd\u5e94\u7684\u4e3b\u8981\u56e0\u7d20\u3002\u56e0\u6b64\uff0c\u4e0e\u9aa8\u9ad3\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u76f8\u6bd4\uff0c\u8110\u5e26\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u7684\u4e0d\u826f\u53cd\u5e94\u53d1\u751f\u7387\u663e\u7740\u964d\u4f4e\u3002<\/span><\/span><\/span><\/p>\n<p><b><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u63d0\u53d6\uff1a<\/span><\/span><\/span><\/b><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u91c7\u96c6\u8fc7\u7a0b\u7b80\u4fbf\u4e14\u65e0\u521b\u3002\u8110\u5e26\u901a\u5e38\u88ab\u89c6\u4e3a\u5206\u5a29\u540e\u7684\u5e9f\u5f03\u7269\uff0c\u56e0\u6b64\uff0c\u8fd9\u79cd\u91c7\u96c6\u65b9\u5f0f\u5728\u4f26\u7406\u4e0a\u662f\u53ef\u4ee5\u63a5\u53d7\u7684\uff0c\u5e76\u4e14\u80fd\u591f\u83b7\u5f97\u5927\u91cf\u7684\u7ec6\u80de\u3002<\/span><\/span><\/span><\/p>\n<p><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8fd9\u4e9b\u4f18\u52bf\u4f7f\u5f97hUC-MSCs \u5728\u81ea\u4f53\u548c\u5f02\u4f53\u5e72\u7ec6\u80de\u6cbb\u7597\u4e2d\u5360\u636e\u4e86\u4e0a\u98ce\u3002<\/span><\/span><\/span><\/p>\n<h2><span class=\"ez-toc-section\" id=\"%E7%94%9F%E7%89%A9%E5%AD%A6%E7%89%B9%E5%BE%81\"><\/span><b><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u751f\u7269\u5b66\u7279\u5f81<\/span><\/span><\/span><\/b><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4eba\u8110\u5e26\u4e2d\u542b\u6709\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09\uff0c\u5206\u5e03\u4e8e\u4e09\u4e2a\u533a\u57df\uff1a\u5185\u76ae\u7ec6\u80de\u5c42\u3001\u8840\u7ba1\u5468\u56f4\u533a\u57df\u548c\u534e\u901a\u6c0f\u80f6\u5c42\u3002\u534e\u901a\u6c0f\u80f6\u5c42\u662f\u4e00\u79cd\u5bcc\u542bMSCs\u7684\u6d77\u7ef5\u72b6\u7ec4\u7ec7\u3002\u79d1\u5b66\u5bb6\u5df2\u8bc1\u5b9e\uff0c\u4e0d\u540c\u8110\u5e26\u533a\u57df\u4e2dMSCs\u7684\u6f5c\u80fd\u76f8\u4f3c\u3002\u4ece\u8110\u5e26\u8840\u6216\u534e\u901a\u6c0f\u80f6\u5c42\u4e2d\u63d0\u53d6\u4eba\u8110\u5e26\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08hUC-MSCs\uff09\u662f\u5e38\u7528\u7684\u65b9\u6cd5\u3002\u4ece\u534e\u901a\u6c0f\u80f6\u5c42\u63d0\u53d6MSCs\u7684\u65b9\u6cd5\u5305\u62ec\u7ec4\u7ec7\u5757\u57f9\u517b\u6cd5\u548c\u9176\u6d88\u5316\u6cd5\u3002\u5176\u6cbb\u7597\u6f5c\u529b\u4e0d\u4ec5\u6e90\u4e8e\u5176\u518d\u751f\u80fd\u529b\uff0c\u8fd8\u6e90\u4e8e\u4ee5\u4e0b\u751f\u7269\u5b66\u7279\u6027\u3002\u672c\u6587\u4e2d\uff0chUC-MSCs\u5747\u6307\u4ece\u534e\u901a\u6c0f\u80f6\u5c42\u63d0\u53d6\u7684MSCs\u3002<\/span><\/span><\/span><\/p>\n<p><b><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u514d\u75ab\u8c03\u8282\uff1a<\/span><\/span><\/span><\/b><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5b83\u4eec\u6291\u5236\u9002\u5e94\u6027\u514d\u75ab\u7cfb\u7edf\uff0c\u5e76\u4f7f\u5de8\u566c\u7ec6\u80de\u6781\u5316\u4e3aM2\u8868\u578b\u4ee5\u8fdb\u884c\u4fee\u590d\u3002\u5b83\u4eec\u8fd8\u80fd\u589e\u52a0\u8c03\u8282\u81ea\u8eab\u514d\u75ab\u53cd\u5e94\u7684\u8c03\u8282\u6027T\u7ec6\u80de\uff08Treg\uff09\u7684\u6c34\u5e73\u3002<\/span><\/span><\/span><\/p>\n<p><b><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u65c1\u5206\u6ccc\u6548\u5e94\uff1a<\/span><\/span><\/span><\/b><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8fd9\u4e9b\u7ec6\u80de\u5206\u6ccc\u591a\u79cd\u53ef\u6eb6\u6027\u751f\u957f\u56e0\u5b50\uff0c\u5305\u62ec\u809d\u7ec6\u80de\u751f\u957f\u56e0\u5b50\uff08HGF\uff09\u3001\u89d2\u8d28\u5f62\u6210\u7ec6\u80de\u751f\u957f\u56e0\u5b50\uff08KGF\uff09\u3001\u8868\u76ae\u751f\u957f\u56e0\u5b50\uff08EGF\uff09\u7b49\u3002\u8fd9\u4e9b\u56e0\u5b50\u53ef\u8bf1\u5bfc\u7ec4\u7ec7\u518d\u751f\u3002<\/span><\/span><\/span><\/p>\n<p><b><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6297\u708e\u4f5c\u7528\uff1a<\/span><\/span><\/span><\/b><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5b83\u4eec\u8fd8\u4f1a\u5206\u6ccc\u6297\u708e\u4ecb\u8d28\uff0c\u5982IL4\u3001IL10\u3001TGF\u03b21\u7b49\uff0c\u540c\u65f6\u6291\u5236\u4fc3\u708e\u7ec6\u80de\u56e0\u5b50\u7684\u5206\u6ccc\u3002<\/span><\/span><\/span><\/p>\n<p><b><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6297\u6c27\u5316\u5242\uff1a<\/span><\/span><\/span><\/b><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5b83\u4eec\u8fd8\u80fd\u7f13\u89e3\u7ec6\u80de\u7684\u6c27\u5316\u5e94\u6fc0\uff0c\u4ece\u800c\u51cf\u5c11\u7ec6\u80de\u51cb\u4ea1\u3002<\/span><\/span><\/span><\/p>\n<p><b><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6297\u7ea4\u7ef4\u5316\uff1a<\/span><\/span><\/span><\/b><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7ea4\u7ef4\u5316\u662f\u591a\u79cd\u75be\u75c5\u7684\u4e3b\u8981\u5206\u5b50\u4e8b\u4ef6\u3002 hUC-MSCs\u901a\u8fc7\u4fc3\u8fdb\u7ea4\u7ef4\u5316\u76f8\u5173\u7ec6\u80de\u51cb\u4ea1\u548c\u8c03\u8282\u76f8\u5173\u4fe1\u53f7\u901a\u8def\u6765\u51cf\u8f7b\u7ea4\u7ef4\u5316\u3002<\/span><\/span><\/span><\/p>\n<h3><span class=\"ez-toc-section\" id=\"%E5%85%8D%E7%96%AB%E6%8A%91%E5%88%B6%E7%89%B9%E6%80%A7\"><\/span><b><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u514d\u75ab\u6291\u5236\u7279\u6027<\/span><\/span><\/span><\/b><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u514d\u75ab\u7cfb\u7edf\u7684\u8c03\u8282\u6216\u6291\u5236\u4fc3\u8fdb\u4e86\u4eba\u8110\u5e26\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08hUC-MSCs\uff09\u7684\u5e94\u7528\u3002\u5b83\u4eec\u8868\u8fbe\u7684HLA\u5206\u5b50\u6c34\u5e73\u6781\u4f4e\uff0c\u4e14\u7f3a\u4e4fCD80\u548cCD86\u7684\u8868\u8fbe\uff0c\u800cCD80\u548cCD86\u662f\u5bfc\u81f4T\u7ec6\u80de\u6d3b\u5316\u7684\u5206\u5b50\u3002\u56e0\u6b64\uff0c\u540c\u79cd\u5f02\u4f53\u79fb\u690d\u540e\u53d1\u751f\u514d\u75ab\u6392\u65a5\u7684\u53ef\u80fd\u6027\u8f83\u4f4e\u3002\u6b64\u5916\uff0c\u8fd9\u4e9b\u7ec6\u80de\u8fd8\u4f1a\u91ca\u653e\u524d\u5217\u817a\u7d20E2\uff08PGE-2\uff09\u3001HLA-G5\u3001\u5432\u54da\u80fa2,3-\u53cc\u52a0\u6c27\u9176\uff08IDO\uff09\u7b49\u56e0\u5b50\uff0c\u4ece\u800c\u6291\u5236\u514d\u75ab\u7ec6\u80de\u7684\u589e\u6b96\u3002\u7814\u7a76\u8868\u660e\uff0c\u7528\u6d3b\u5316\u7684\u514d\u75ab\u7ec6\u80de\u6216\u4ecb\u8d28\u9884\u5904\u7406hUC-MSCs\u53ef\u4f7f\u5176\u8f6c\u5316\u4e3a\u514d\u75ab\u6291\u5236\u5242\u3002\u5b83\u4eec\u8fd8\u80fd\u6291\u5236\u6811\u7a81\u72b6\u7ec6\u80de\u7684\u5206\u5316\u548c\u6210\u719f\u3002\u6b64\u5916\uff0c\u5b83\u4eec\u8fd8\u4f1a\u91ca\u653e\u6fc0\u6d3b\u7d20A\u548cHLA-G6\uff0c\u4ee5\u6291\u5236\u81ea\u7136\u6740\u4f24\uff08NK\uff09\u7ec6\u80de\u91ca\u653e\u7684\u5e72\u6270\u7d20-\u03b3\uff08INF-\u03b3\uff09\u53ca\u5176\u7ec6\u80de\u6bd2\u6d3b\u6027\u3002 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inherit;\">\u76ee\u524d\u5df2\u6709\u8d85\u8fc7100\u9879\u91c7\u7528\u4eba\u8110\u5e26\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08hUC-MSCs\uff09\u7684\u4e34\u5e8a\u8bd5\u9a8c\u6b63\u5728\u8fdb\u884c\u6216\u5df2\u5b8c\u6210\u3002\u7136\u800c\uff0c\u4eba\u4eec\u5bf9\u5176\u5b89\u5168\u6027\u4ecd\u5b58\u5728\u4e00\u4e9b\u7591\u8651\u3002\u9020\u8840\u5e72\u7ec6\u80de\u79fb\u690d\u66fe\u51fa\u73b0\u514d\u75ab\u6392\u65a5\u548c\u79fb\u690d\u7269\u6297\u5bbf\u4e3b\u75c5\uff08GVHD\uff09\uff0c\u800c\u80da\u80ce\u5e72\u7ec6\u80de\uff08ESCs\uff09\u5219\u6613\u5f62\u6210\u80bf\u7624\u3002\u56e0\u6b64\uff0c\u5c06hUC-MSC\u79fb\u690d\u4e0e\u8fd9\u4e9b\u56e0\u7d20\u8054\u7cfb\u8d77\u6765\u8003\u8651\u662f\u5408\u4e4e\u903b\u8f91\u7684\u3002\u7136\u800c\uff0c\u65e0\u8bba\u662f\u52a8\u7269\u7814\u7a76\u8fd8\u662f\u4eba\u4f53\u7814\u7a76\uff0c\u5747\u672a\u62a5\u544a\u4efb\u4f55\u4e0d\u826f\u53cd\u5e94\uff0c\u8868\u660e\u8be5\u7ec6\u80de\u5177\u6709\u826f\u597d\u7684\u8010\u53d7\u6027\u3002 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inherit;\">\u591a\u79cd\u75be\u75c5\uff0c\u7279\u522b\u662f\u90a3\u4e9b\u7f3a\u4e4f\u6709\u6548\u6cbb\u7597\u65b9\u6cd5\u7684\u75be\u75c5\uff0c\u90fd\u53ef\u91c7\u7528\u4eba\u8110\u5e26\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u8fdb\u884c\u6cbb\u7597\u3002\u8fd9\u4e9b\u75be\u75c5\u4e3b\u8981\u5305\u62ec\u7ec4\u7ec7\u635f\u4f24\u548c\u9000\u884c\u6027\u75be\u75c5\u3002<\/span><\/span><\/span><\/p>\n<p><b><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7cd6\u5c3f\u75c5\uff1a<\/span><\/span><\/span><\/b><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7cd6\u5c3f\u75c5\u7684\u7279\u5f81\u662f\u9ad8\u8840\u7cd6\uff0c\u6839\u636e\u75c5\u56e0\u53ef\u5927\u81f4\u5206\u4e3aI\u578b\u548cII\u578b\u3002\u60a3\u8005\u901a\u5e38\u4f1a\u5bf9\u80f0\u5c9b\u7d20\u4ea7\u751f\u4f9d\u8d56\u6027\uff0c\u957f\u671f\u4f7f\u7528\u4f1a\u5bfc\u81f4\u5e76\u53d1\u75c7\u3002 hUC-MSC\u8f93\u6ce8\u53ef\u5206\u5316\u4e3a\u4ea7\u751f\u80f0\u5c9b\u7d20\u7684\u80f0\u5c9b\u7ec6\u80de\u3002\u6b64\u5916\uff0c\u4e34\u5e8a\u7814\u7a76\u8868\u660e\uff0c\u8f93\u6ce8hUC-MSC\u53ef\u6539\u5584\u80f0\u5c9b\u7d20\u6c34\u5e73\uff0c\u4f7f\u8840\u7cd6\u6062\u590d\u6b63\u5e38\uff0c\u5e76\u964d\u4f4e\u5bf9\u836f\u7269\u7684\u4f9d\u8d56\u6027\u3002<\/span><\/span><\/span><\/p>\n<p><b><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u809d\u635f\u4f24\uff1a<\/span><\/span><\/span><\/b><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u809d\u635f\u4f24\u901a\u5e38\u53d1\u751f\u5728\u7ea4\u7ef4\u5316\u9636\u6bb5\uff0c\u5373\u809d\u661f\u72b6\u7ec6\u80de\u8fc7\u5ea6\u79ef\u7d2f\u7ec6\u80de\u5916\u57fa\u8d28\u3002\u8110\u5e26\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09\u901a\u8fc7\u8868\u8fbe\u57fa\u8d28\u91d1\u5c5e\u86cb\u767d\u9176\uff0c\u523a\u6fc0\u8fd9\u4e9b\u7ec6\u80de\u51cb\u4ea1\u5e76\u964d\u89e3\u57fa\u8d28\u3002\u5b83\u4eec\u8fd8\u80fd\u51cf\u8f7b\u4e2d\u6027\u7c92\u7ec6\u80de\u52df\u96c6\u3001\u809d\u7ec6\u80de\u51cb\u4ea1\u3001\u708e\u75c7\u548c\u6c27\u5316\u5e94\u6fc0\uff0c\u4ece\u800c\u4fdd\u62a4\u809d\u810f\u514d\u53d7\u7f3a\u8840\u518d\u704c\u6ce8\u635f\u4f24\u3002\u901a\u8fc7\u8c03\u8282\u661f\u72b6\u7ec6\u80de\u7684\u589e\u6b96\uff0c\u5b83\u4eec\u53ef\u4ee5\u5ef6\u7f13\u751a\u81f3\u9006\u8f6c\u809d\u635f\u4f24\u3002<\/span><\/span><\/span><\/p>\n<p><b><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5173\u8282\u708e\uff1a<\/span><\/span><\/span><\/b><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5173\u8282\u708e\u662f\u4e00\u79cd\u7531\u591a\u79cd\u56e0\u7d20\u5f15\u53d1\u7684\u5173\u8282\u9000\u884c\u6027\u75be\u75c5\u3002\u8110\u5e26\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09\u901a\u8fc7\u5206\u5316\u4e3a<\/span><\/span><\/span><strong><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6210\u9aa8\u7ec6\u80de<\/span><\/span><\/span><\/strong><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: 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