{"id":20605,"date":"2025-11-21T17:45:22","date_gmt":"2025-11-21T09:45:22","guid":{"rendered":"https:\/\/www.hjtdsm.cn\/?p=20605"},"modified":"2025-11-21T17:45:44","modified_gmt":"2025-11-21T09:45:44","slug":"https-www-hjtdsm-cn-stem-cells-ct-20605-html","status":"publish","type":"post","link":"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/ct\/20605.html","title":{"rendered":"\u4ec0\u4e48\u662f\u6811\u7a81\u72b6\u7ec6\u80de\uff1f\u5b83\u4eec\u5728\u514d\u75ab\u751f\u7269\u5b66\u4e2d\u7684\u4f5c\u7528\u662f\u4ec0\u4e48\uff1f"},"content":{"rendered":"<p><span dir=\"auto\">\u6811\u7a81\u72b6\u7ec6\u80de\u662f\u5177\u6709\u72ec\u7279\u529f\u80fd\u7684<a href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/ct\/20061.html\/\" target=\"_blank\" 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style=\"cursor:inherit\">Table of Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewbox=\"0 0 24 24\" version=\"1.2\" baseprofile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 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>\u5355\u6838\u7ec6\u80de\u6765\u6e90\u7684\u6811\u7a81\u72b6\u7ec6\u80de\uff08moDCs\uff09<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/ct\/20605.html\/#%E4%B8%B4%E5%BA%8A%E7%9B%B8%E5%85%B3%E6%80%A7\" >\u4e34\u5e8a\u76f8\u5173\u6027<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/ct\/20605.html\/#%E6%A0%91%E7%AA%81%E7%8A%B6%E7%BB%86%E8%83%9E%E7%96%97%E6%B3%95\" >\u6811\u7a81\u72b6\u7ec6\u80de\u7597\u6cd5<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/ct\/20605.html\/#%E7%BB%93%E8%AE%BA\" >reach a verdict<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/ct\/20605.html\/#%E5%B8%B8%E8%A7%81%E9%97%AE%E9%A2%98%E8%A7%A3%E7%AD%94\" >\u5e38\u89c1\u95ee\u9898\u89e3\u7b54<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/ct\/20605.html\/#%E9%97%AE%EF%BC%9A%E6%A0%91%E7%AA%81%E7%8A%B6%E7%BB%86%E8%83%9E%E6%9C%89%E5%93%AA%E4%BA%9B%E5%8A%9F%E8%83%BD%EF%BC%9F\" >\u95ee\uff1a\u6811\u7a81\u72b6\u7ec6\u80de\u6709\u54ea\u4e9b\u529f\u80fd\uff1f<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/ct\/20605.html\/#%E9%97%AE%EF%BC%9A%E6%A0%91%E7%AA%81%E7%8A%B6%E7%BB%86%E8%83%9E%E6%9C%89%E5%93%AA%E4%BA%9B%E7%8B%AC%E7%89%B9%E7%89%B9%E5%BE%81%EF%BC%9F\" >\u95ee\uff1a\u6811\u7a81\u72b6\u7ec6\u80de\u6709\u54ea\u4e9b\u72ec\u7279\u7279\u5f81\uff1f<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-16\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/ct\/20605.html\/#%E9%97%AE%EF%BC%9A%E6%A0%91%E7%AA%81%E7%8A%B6%E7%BB%86%E8%83%9E%E5%A6%82%E4%BD%95%E5%BC%95%E8%B5%B7%E7%A7%BB%E6%A4%8D%E7%89%A9%E6%8A%97%E5%AE%BF%E4%B8%BB%E7%97%85%EF%BC%9F\" >\u95ee\uff1a\u6811\u7a81\u72b6\u7ec6\u80de\u5982\u4f55\u5f15\u8d77\u79fb\u690d\u7269\u6297\u5bbf\u4e3b\u75c5\uff1f<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-17\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/ct\/20605.html\/#%E9%97%AE%EF%BC%9A%E6%A0%91%E7%AA%81%E7%8A%B6%E7%BB%86%E8%83%9E%E5%8F%82%E4%B8%8E%E5%93%AA%E4%BA%9B%E4%B8%8D%E5%90%8C%E7%9A%84%E7%96%BE%E7%97%85%EF%BC%9F\" >\u95ee\uff1a\u6811\u7a81\u72b6\u7ec6\u80de\u53c2\u4e0e\u54ea\u4e9b\u4e0d\u540c\u7684\u75be\u75c5\uff1f<\/a><\/li><\/ul><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"%E6%A0%91%E7%AA%81%E7%8A%B6%E7%BB%86%E8%83%9E\"><\/span><b><span dir=\"auto\">\u6811\u7a81\u72b6\u7ec6\u80de<\/span><\/b><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span dir=\"auto\">1973\u5e74\uff0c\u4e24\u4f4d\u52a0\u62ff\u5927\u79d1\u5b66\u5bb6\u62c9\u5c14\u592b\u00b7\u65af\u5766\u66fc\u548c\u8d5e\u7ef4\u5c14\u00b7\u79d1\u6069\u5728\u5c0f\u9f20\u813e\u810f\u548c\u5916\u5468\u6dcb\u5df4\u7ed3\u4e2d\u53d1\u73b0\u4e86<\/span><strong><span dir=\"auto\">\u6811\u7a81\u72b6\u7ec6\u80de<\/span><\/strong><span dir=\"auto\">\uff08DCs\uff09\u3002\u4ed6\u4eec\u6839\u636e\u8fd9\u4e9b\u7ec6\u80de\u7684\u80de\u8d28\u7a81\u8d77\u5c06\u5176\u547d\u540d\u4e3a\u6811\u7a81\u72b6\u7ec6\u80de\u3002\u6811\u7a81\u72b6\u7ec6\u80de\u8d77\u6e90\u4e8e\u9aa8\u9ad3\u4e2d\u7684\u9020\u8840\u5e72\u7ec6\u80de\u3002\u5b83\u4eec\u904d\u5e03\u5168\u8eab\u2014\u2014\u8840\u6db2\u3001\u6dcb\u5df4\u7ec4\u7ec7\u548c\u975e\u6dcb\u5df4\u7ec4\u7ec7\u3002<\/span><\/p>\n<h3><span class=\"ez-toc-section\" id=\"%E6%A0%91%E7%AA%81%E7%8A%B6%E7%BB%86%E8%83%9E%E7%9A%84%E5%8A%9F%E8%83%BD\"><\/span><b><span dir=\"auto\">\u6811\u7a81\u72b6\u7ec6\u80de\u7684\u529f\u80fd<\/span><\/b><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span dir=\"auto\">\u6811\u7a81\u72b6\u7ec6\u80de\uff08DC\uff09\u662fT\u6dcb\u5df4\u7ec6\u80de\u6700\u6709\u6548\u7684\u6297\u539f\u5448\u9012\u7ec6\u80de\uff08APC\uff09\u3002\u5b83\u4eec\u5728\u514d\u75ab\u7cfb\u7edf\u53cd\u5e94\u4e2d\u53d1\u6325\u7740\u51e0\u4e2a\u81f3\u5173\u91cd\u8981\u7684\u4f5c\u7528\uff08\u56fe1\uff09\u3002<\/span><\/p>\n<h3><span class=\"ez-toc-section\" id=\"%E5%85%8D%E7%96%AB%E5%8F%8D%E5%BA%94\"><\/span><b><span dir=\"auto\">\u514d\u75ab\u53cd\u5e94<\/span><\/b><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span dir=\"auto\">\u6811\u7a81\u72b6\u7ec6\u80de\uff08DC\uff09\u4f5c\u4e3a\u6297\u539f\u5448\u9012\u7ec6\u80de\uff08APC\uff09\u5411T\u6dcb\u5df4\u7ec6\u80de\u5448\u9012\u6297\u539f\uff0c\u540c\u65f6\u4e5f\u4e0eB\u6dcb\u5df4\u7ec6\u80de\u548c\u5de8\u566c\u7ec6\u80de\u76f8\u4e92\u4f5c\u7528\u3002\u9aa8\u9ad3\u9020\u8840\u8fc7\u7a0b\u4ea7\u751f\u672a\u6210\u719f\u7684DC\u3002\u8fd9\u4e9bDC\u8fc1\u79fb\u81f3\u975e\u6dcb\u5df4\u7ec4\u7ec7\uff0c\u76d1\u6d4b\u75c5\u539f\u4f53\u6297\u539f\u3002DC\u8868\u9762\u542b\u6709\u6a21\u5f0f\u8bc6\u522b\u53d7\u4f53\uff08PRR\uff09\u3002PRR\u8bc6\u522b\u75c5\u539f\u4f53\u8868\u9762\u7684\u6a21\u5f0f\u76f8\u5173\u5206\u5b50\u6a21\u5f0f\uff08PAMP\uff09\uff0c\u8fd9\u4e9b\u6a21\u5f0f\u662f\u75c5\u539f\u4f53\u8fdb\u5316\u4e0a\u4fdd\u5b88\u7684\u533a\u57df\u3002\u8bc6\u522b\u6297\u539f\u540e\uff0cDC\u6444\u53d6\u6297\u539f\u5e76\u8fdb\u884c\u6210\u719f\u3002\u5b83\u4eec\u8fc1\u79fb\u81f3\u6dcb\u5df4\u7ed3\uff0c\u5e76\u5931\u53bb\u6297\u539f\u6444\u53d6\u80fd\u529b\u3002\u4e3a\u4e86\u8f6c\u5316\u4e3aAPC\uff0c\u5b83\u4eec\u8868\u8fbe\u4e3b\u8981\u7ec4\u7ec7\u76f8\u5bb9\u6027\u590d\u5408\u4f53\uff08MHC\uff09I\u7c7b\u548cII\u7c7b\u5206\u5b50\u4ee5\u53ca\u5171\u523a\u6fc0\u5206\u5b50CD40\u3001CD80\u548cCD86\u3002\u6210\u719f\u7684DC\u5c06\u6297\u539f\u5448\u9012\u7ed9T\u6dcb\u5df4\u7ec6\u80de\uff0c\u523a\u6fc0T\u6dcb\u5df4\u7ec6\u80de\u4ea7\u751f\u767d\u7ec6\u80de\u4ecb\u7d20-2\uff08IL-2\uff09\u3002IL-2\u53cd\u8fc7\u6765\u4fc3\u8fdbT\u6dcb\u5df4\u7ec6\u80de\u6269\u589e\u3001B\u6dcb\u5df4\u7ec6\u80de\u53d1\u80b2\u548c\u6297\u4f53\u4ea7\u751f\u3002<\/span><\/p>\n<div id=\"attachment_20606\" style=\"width: 998px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-20606\" class=\"wp-image-20606 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5fae\u4fe1\u56fe\u7247_2025-11-21_173254_760.png\" alt=\"\" width=\"988\" height=\"913\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5fae\u4fe1\u56fe\u7247_2025-11-21_173254_760.png 988w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5fae\u4fe1\u56fe\u7247_2025-11-21_173254_760-300x277.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5fae\u4fe1\u56fe\u7247_2025-11-21_173254_760-768x710.png 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5fae\u4fe1\u56fe\u7247_2025-11-21_173254_760-13x12.png 13w\" sizes=\"(max-width: 988px) 100vw, 988px\" \/><p id=\"caption-attachment-20606\" class=\"wp-caption-text\">\u56fe 1. \u6811\u7a81\u72b6\u7ec6\u80de (DC) \u7684\u4e0d\u540c\u529f\u80fd<\/p><\/div>\n<figure id=\"attachment_31359\" class=\"wp-caption aligncenter\" aria-describedby=\"caption-attachment-31359\"><\/figure>\n<p><span dir=\"auto\">\u6811\u7a81\u72b6\u7ec6\u80de\uff08DC\uff09\u901a\u8fc7\u5c06\u81ea\u8eab\u6297\u539f\u5448\u9012\u7ed9T\u6dcb\u5df4\u7ec6\u80de\u6765\u7ef4\u6301\u514d\u75ab\u7a33\u6001\uff0c\u4ece\u800c\u4e5f\u53c2\u4e0e\u514d\u75ab\u8010\u53d7\u7684\u5f62\u6210\u3002\u514d\u75ab\u8010\u53d7\u5206\u4e3a\u4e2d\u67a2\u8010\u53d7\u548c\u5916\u5468\u8010\u53d7\u4e24\u79cd\u3002\u5728\u4e2d\u67a2\u8010\u53d7\u4e2d\uff0cDC\u53c2\u4e0e\u6e05\u9664\u4e0e\u81ea\u8eab\u6297\u539f\u9ad8\u4eb2\u548c\u529b\u7ed3\u5408\u7684T\u6dcb\u5df4\u7ec6\u80de\u3002\u8fd9\u4e00\u9009\u62e9\u8fc7\u7a0b\u53d1\u751f\u5728\u80f8\u817a\u4e2d\u3002\u6b64\u5916\uff0c\u5728\u6ca1\u6709\u611f\u67d3\u7684\u60c5\u51b5\u4e0b\uff0c\u672a\u6210\u719f\u7684DC\u4f1a\u76d1\u6d4b\u73af\u5883\u4e2d\u7684\u81ea\u8eab\u6297\u539f\uff0c\u4f8b\u5982\u7ec6\u80de\u788e\u7247\u3001\u51cb\u4ea1\u7ec6\u80de\u7b49\uff0c\u4ee5\u53ca\u751f\u547d\u540e\u671f\u9636\u6bb5\u5b58\u5728\u7684\u7ec6\u80de\u3002\u8fd9\u4e9b\u7ec6\u80de\u65e0\u6cd5\u8fdb\u5165\u80f8\u817a\u3002\u56e0\u6b64\uff0cDC\u4f1a\u6355\u83b7\u5e76\u5904\u7406\u8fd9\u4e9b\u6297\u539f\uff0c\u4ece\u800c\u53c2\u4e0e\u5916\u5468\u8010\u53d7\u7684\u5f62\u6210\u3002<\/span><\/p>\n<h3><span class=\"ez-toc-section\" id=\"%E4%BA%A4%E5%8F%89%E5%B1%95%E7%A4%BA\"><\/span><strong><span dir=\"auto\">\u4ea4\u53c9\u5c55\u793a<\/span><\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span dir=\"auto\">\u6811\u7a81\u72b6\u7ec6\u80de\uff08DC\uff09\u5177\u6709\u72ec\u7279\u7684\u4ea4\u53c9\u5448\u9012\u529f\u80fd\u3002\u901a\u5e38\uff0c\u6297\u539f\u5448\u9012\u7ec6\u80de\uff08APC\uff09\u901a\u8fc7MHC I\u7c7b\u5206\u5b50\u5c06\u5185\u6e90\u6027\u6297\u539f\u5448\u9012\u7ed9CD8+ T\u6dcb\u5df4\u7ec6\u80de\u3002\u76f8\u53cd\uff0cCD4+ T\u6dcb\u5df4\u7ec6\u80de\u8bc6\u522bMHC II\u7c7b\u5206\u5b50\u4e0a\u7684\u5916\u6e90\u6027\u6297\u539f\u3002\u7136\u800c\uff0c\u6811\u7a81\u72b6\u7ec6\u80de\u80fd\u591f\u901a\u8fc7MHC I\u7c7b\u5206\u5b50\u5c06\u5916\u6e90\u6027\u6297\u539f\u4ea4\u53c9\u5448\u9012\u7ed9CD8+ T\u6dcb\u5df4\u7ec6\u80de\u3002<\/span><\/p>\n<h3><span class=\"ez-toc-section\" id=\"%E6%A0%91%E7%AA%81%E7%8A%B6%E7%BB%86%E8%83%9E%E7%9A%84%E5%BC%82%E8%B4%A8%E6%80%A7\"><\/span><strong><span dir=\"auto\">\u6811\u7a81\u72b6\u7ec6\u80de\u7684\u5f02\u8d28\u6027<\/span><\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span 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id=\"%E6%A0%91%E7%AA%81%E7%8A%B6%E7%BB%86%E8%83%9E%E7%9A%84%E7%B1%BB%E5%9E%8B\"><\/span><strong><span dir=\"auto\">\u6811\u7a81\u72b6\u7ec6\u80de\u7684\u7c7b\u578b<\/span><\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span dir=\"auto\">\u6811\u7a81\u72b6\u7ec6\u80de\u7684\u5f02\u8d28\u6027\u5bfc\u81f4\u5b83\u4eec\u88ab\u5206\u4e3a\u4e0d\u540c\u7684\u4e9a\u7fa4\u3002\u8fd9\u4e9b\u4e9a\u7fa4\u5b58\u5728\u4e8e\u5faa\u73af\u7cfb\u7edf\u548c\u7ec4\u7ec7\u4e2d\u3002<\/span><\/p>\n<h3><span class=\"ez-toc-section\" id=\"%E4%BC%A0%E7%BB%9F%E6%88%96%E7%BB%8F%E5%85%B8%E6%A0%91%E7%AA%81%E7%8A%B6%E7%BB%86%E8%83%9E%EF%BC%88cDCs%EF%BC%89\"><\/span><strong><span dir=\"auto\">\u4f20\u7edf\u6216\u7ecf\u5178\u6811\u7a81\u72b6\u7ec6\u80de\uff08cDCs\uff09<\/span><\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span dir=\"auto\">\u5b83\u4eec\u8fd8\u5305\u542b\u4e24\u4e2a\u4e9a\u7fa4\u3002\u5728\u5c0f\u9f20\u4e2d\uff0c\u8fd9\u4e9b\u4e9a\u7fa4\u53ef\u901a\u8fc7\u5176CD8\u03b1\u548cCD103\u6216CD11b\u7684\u8868\u8fbe\u6765\u8bc6\u522b\u3002\u8868\u8fbeCD8\u03b1\u6216CD103\u7684\u4e9a\u7fa4\u8868\u73b0\u51fa\u72ec\u7279\u7684\u4ea4\u53c9\u5448\u9012\u80fd\u529b\u3002\u6b64\u5916\uff0cCD8\u03b1\u9633\u6027cDC\u8fd8\u53ef\u4ee5\u8868\u8fbeCD1d\u7cd6\u8102\uff0c\u5e76\u6781\u5316\u81ea\u7136\u6740\u4f24T\u6dcb\u5df4\u7ec6\u80de\u5f62\u6210\u8f85\u52a9\u6027T\u6dcb\u5df4\u7ec6\u80de\u6216\u4ea7\u751fTh2\u7ec6\u80de\u56e0\u5b50\u3002\u8868\u8fbeCD11b\u7684cDC\u662f\u6dcb\u5df4\u7ec4\u7ec7\u4e2d\u6700\u4e30\u5bcc\u7684\u6811\u7a81\u72b6\u7ec6\u80de\u3002\u4ea7\u751fIL-6\u548cIL-23\u4e5f\u662fCD11b\u9633\u6027cDC\u7684\u4e00\u4e2a\u663e\u8457\u7279\u5f81\u3002<\/span><\/p>\n<h3><span class=\"ez-toc-section\" id=\"%E6%B5%86%E7%BB%86%E8%83%9E%E6%A0%B7%E6%A0%91%E7%AA%81%E7%8A%B6%E7%BB%86%E8%83%9E%EF%BC%88pDCs%EF%BC%89\"><\/span><strong><span dir=\"auto\">\u6d46\u7ec6\u80de\u6837\u6811\u7a81\u72b6\u7ec6\u80de\uff08pDCs\uff09<\/span><\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span dir=\"auto\">\u5b83\u4eec\u8d77\u6e90\u4e8e\u6dcb\u5df4\u524d\u4f53\u7ec6\u80de\u3002\u7531\u4e8e\u5b83\u4eec\u80fd\u591f\u5206\u5316\u4e3a\u7ecf\u5178\u6811\u7a81\u72b6\u7ec6\u80de\uff08cDC\uff09\uff0c\u56e0\u6b64\u5728\u4e0d\u540c\u7ec4\u7ec7\u4e2d\u7684\u6570\u91cf\u6709\u6240\u4e0d\u540c\u3002\u5b83\u4eec\u5448\u5706\u5f62\uff0c\u5177\u6709\u4e0e\u6dcb\u5df4\u7ec6\u80de\u76f8\u4f3c\u7684\u6d46\u7ec6\u80de\u6837\u5f62\u6001\u3002\u5b83\u4eec\u4e5f\u542b\u6709\u5206\u6ccc\u8154\u3002\u8fd9\u4e9b\u4f11\u7720\u7ec6\u80de\u5728\u53d7\u5230 Toll \u6837\u53d7\u4f53\uff08TLR\uff097 \u548c TLR9 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dir=\"auto\">\u5355\u6838\u7ec6\u80de\u6765\u6e90\u7684\u6811\u7a81\u72b6\u7ec6\u80de\uff08moDCs\uff09\u7531\u9ad3\u7cfb\u524d\u4f53\u7ec6\u80de\u5206\u5316\u800c\u6765\u3002\u5355\u6838\u7ec6\u80de\u5728\u8840\u6db2\u4e2d\u5faa\u73af\uff0c\u8868\u8fbe<\/span><strong><span dir=\"auto\">\u751f\u957f\u56e0\u5b50<\/span><\/strong><span dir=\"auto\">\u3001\u7ec6\u80de\u56e0\u5b50\u548c\u8d8b\u5316\u56e0\u5b50\u7684\u53d7\u4f53\u3002\u8fd9\u4e9b\u53d7\u4f53\u9a71\u52a8\u5355\u6838\u7ec6\u80de\u5411\u611f\u67d3\u6216\u708e\u75c7\u90e8\u4f4d\u8fc1\u79fb\u3002\u968f\u540e\uff0c\u5b83\u4eec\u5206\u5316\u4e3amoDCs\uff0c\u5e76\u91ca\u653e\u80bf\u7624\u574f\u6b7b\u56e0\u5b50\u03b1\uff08TNF-\u03b1\uff09\u548c\u8bf1\u5bfc\u578b\u4e00\u6c27\u5316\u6c2e\u5408\u9176\uff08iNOS\uff09\u3002\u8fd9\u4e9b\u5206\u5b50\u8d4b\u4e88moDCs\u56fa\u6709\u514d\u75ab\u4fdd\u62a4\u80fd\u529b\uff0c\u56e0\u6b64\u5b83\u4eec\u4e5f\u88ab\u79f0\u4e3a\u4ea7\u751fTNF-\u03b1\u548ciNOS\u7684\u6811\u7a81\u72b6\u7ec6\u80de\u3002\u5b83\u4eec\u5728\u6297\u539f\u52a0\u5de5\u3001\u5448\u9012\u548c\u4ea4\u53c9\u5448\u9012\u65b9\u9762\u5177\u6709\u5f88\u5f3a\u7684\u6d3b\u6027\u3002\u5c3d\u7ba1moDCs\u548cCD11\u9633\u6027\u4e9a\u7fa4\u7684\u7ecf\u5178\u6811\u7a81\u72b6\u7ec6\u80de\uff08cDCs\uff09\u5177\u6709\u76f8\u4f3c\u7684\u6807\u5fd7\u7269\uff0c\u4f46moDCs\u53ef\u4ee5\u901a\u8fc7Fc\u03b3\u53d7\u4f53I\uff08Fc\u03b3RI\uff09\u548cCD64\u7684\u8868\u8fbe\u6765\u533a\u5206\u3002<\/span><\/p>\n<h2><span class=\"ez-toc-section\" id=\"%E4%B8%B4%E5%BA%8A%E7%9B%B8%E5%85%B3%E6%80%A7\"><\/span><strong><span dir=\"auto\">\u4e34\u5e8a\u76f8\u5173\u6027<\/span><\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><strong><span dir=\"auto\">\u79fb\u690d\uff1a<\/span><\/strong><span dir=\"auto\">\u79fb\u690d\u7269\u6297\u5bbf\u4e3b\u75c5\uff08GVHD\uff09\u662f\u79fb\u690d\u7684\u5178\u578b\u5e76\u53d1\u75c7\u3002\u5728\u8fd9\u79cd\u60c5\u51b5\u4e0b\uff0c\u79fb\u690d\u7269\u6216\u8f93\u5165\u7684\u7ec6\u80de\u4f1a\u5bf9\u53d7\u4f53\u6216\u5bbf\u4e3b\u53d1\u8d77\u514d\u75ab\u653b\u51fb\u3002\u5bbf\u4e3b\u6811\u7a81\u72b6\u7ec6\u80de\uff08DC\uff09\u901a\u8fc7\u5c06\u5bbf\u4e3b\u6297\u539f\u5448\u9012\u7ed9\u79fb\u690d\u7269\u4e2d\u7684T\u6dcb\u5df4\u7ec6\u80de\u6765\u542f\u52a8\u8fd9\u4e00\u8fc7\u7a0b\u3002\u5728\u5668\u5b98\u79fb\u690d\u4e2d\uff0c\u79fb\u690d\u7269\u4e2d\u7684DC\u4f1a\u5c06\u79fb\u690d\u7269\u6297\u539f\u5448\u9012\u7ed9\u5bbf\u4e3bT\u6dcb\u5df4\u7ec6\u80de\u3002GVHD\u6700\u7ec8\u4f1a\u5bfc\u81f4\u79fb\u690d\u5931\u8d25\u548c\u9ad8\u6b7b\u4ea1\u7387\u3002<\/span><\/p>\n<p><strong><span dir=\"auto\">\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\uff1a<\/span><\/strong><span dir=\"auto\">\u6811\u7a81\u72b6\u7ec6\u80de\uff08DC\uff09\u662f\u514d\u75ab\u8010\u53d7\u7684\u91cd\u8981\u7ec4\u6210\u90e8\u5206\u3002\u591a\u79cd\u9057\u4f20\u548c\u73af\u5883\u56e0\u7d20\u53ef\u5bfc\u81f4\u5176\u8010\u53d7\u53cd\u5e94\u5931\u8861\u3002\u4f8b\u5982\uff0c\u5728\u7cfb\u7edf\u6027\u7ea2\u6591\u72fc\u75ae\u4e2d\uff0c\u6d46\u7ec6\u80de\u6837\u6811\u7a81\u72b6\u7ec6\u80de\uff08pDC\uff09\u91ca\u653e\u5927\u91cf\u5e72\u6270\u7d20\u03b1\uff08IFN\u03b1\uff09\uff0c\u6fc0\u6d3b\u7ecf\u5178\u6811\u7a81\u72b6\u7ec6\u80de\uff08cDC\uff09\uff0c\u7834\u574f\u5176\u5916\u5468\u8010\u53d7\u80fd\u529b\u3002DC\u4e5f\u4e0e\u65e9\u671fI\u578b\u7cd6\u5c3f\u75c5\u7684\u53d1\u75c5\u673a\u5236\u76f8\u5173\u3002\u7531\u4e8eDC\u5728\u7ef4\u6301\u8c03\u8282\u6027T\u6dcb\u5df4\u7ec6\u80de\u65b9\u9762\u53d1\u6325\u7740\u91cd\u8981\u4f5c\u7528\uff0c\u56e0\u6b64\u6709\u7814\u7a76\u63d0\u51fa\uff0c\u589e\u52a0DC\u6570\u91cf\u53ef\u80fd\u6709\u52a9\u4e8e\u6cbb\u7597I\u578b\u7cd6\u5c3f\u75c5\u3002<\/span><\/p>\n<p><strong><span dir=\"auto\">\u764c\u75c7\uff1a<\/span><\/strong><span dir=\"auto\">\u00a0T\u6dcb\u5df4\u7ec6\u80de\u5728\u6297\u80bf\u7624\u514d\u75ab\u4e2d\u53d1\u6325\u7740\u81f3\u5173\u91cd\u8981\u7684\u4f5c\u7528\u3002cDC\u901a\u8fc7\u5185\u541e\u80bf\u7624\u76f8\u5173\u6297\u539f\u6fc0\u6d3bT\u6dcb\u5df4\u7ec6\u80de\uff0c\u8fc1\u79fb\u81f3\u6dcb\u5df4\u7ed3\u5e76\u6fc0\u6d3bT\u6dcb\u5df4\u7ec6\u80de\u3002\u5b83\u4eec\u80fd\u591f\u5448\u9012\u5916\u6e90\u6027\u548c\u5185\u6e90\u6027\u6297\u539f\uff0c\u56e0\u6b64\u9002\u5408\u4fc3\u8fdb<\/span><strong><span dir=\"auto\">T\u7ec6\u80de<\/span><\/strong><span dir=\"auto\">\u5e94\u7b54\u548c\u6781\u5316\u3002\u7136\u800c\uff0c\u80bf\u7624\u7ec6\u80de\u4f1a\u4ea7\u751f\u8bf8\u5982IL-6\u3001IL-10\u548c\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\uff08VEGF\uff09\u7b49\u7ec6\u80de\u56e0\u5b50\uff0c\u8fd9\u4e9b\u56e0\u5b50\u4f1a\u6291\u5236DC\u7684\u5206\u5316\u548c\u6fc0\u6d3b\u3002<\/span><\/p>\n<h3><span class=\"ez-toc-section\" id=\"%E6%A0%91%E7%AA%81%E7%8A%B6%E7%BB%86%E8%83%9E%E7%96%97%E6%B3%95\"><\/span><strong><span dir=\"auto\">\u6811\u7a81\u72b6\u7ec6\u80de\u7597\u6cd5<\/span><\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span dir=\"auto\">\u6811\u7a81\u72b6\u7ec6\u80de\uff08DC\uff09\u80fd\u591f\u6fc0\u6d3b\u9002\u5e94\u6027\u514d\u75ab\u7ec6\u80de\uff0c\u8fdb\u800c\u6fc0\u6d3b\u56fa\u6709\u514d\u75ab\u7cfb\u7edf\u3002\u56e0\u6b64\uff0c\u5b83\u4eec\u8fde\u63a5\u7740\u56fa\u6709\u514d\u75ab\u7cfb\u7edf\u548c\u9002\u5e94\u6027\u514d\u75ab\u7cfb\u7edf\u3002\u8fd9\u4e9b\u7279\u6027\u4fc3\u4f7f\u4eba\u4eec\u5bf9DC\u7684\u6cbb\u7597\u5e94\u7528\u5c55\u5f00\u7814\u7a76\u3002DC\u53ef\u4ee5\u901a\u8fc7\u6fc0\u6d3b\u9002\u5e94\u6027\u514d\u75ab\u7cfb\u7edf\u548c\u56fa\u6709\u514d\u75ab\u7cfb\u7edf\u6765\u589e\u5f3a\u75ab\u82d7\u7684\u514d\u75ab\u539f\u6027\u3002\u57fa\u4e8eDC\u7684\u75ab\u82d7\u5df2\u88ab\u5f00\u53d1\u51fa\u6765\uff0c\u5e76\u88ab\u8bc1\u5b9e\u5b89\u5168\u6709\u6548\u3002DC\u7956\u7ec6\u80de\u5728\u5b9e\u9a8c\u5ba4\u4e2d\u57f9\u517b\uff0c\u5e76\u901a\u8fc7\u6dfb\u52a0\u7ec6\u80de\u56e0\u5b50\u8bf1\u5bfc\u5206\u5316\u4e3aDC\u3002\u8fd9\u4e9b\u7ec6\u80de\u901a\u8fc7\u7535\u7a7f\u5b54\u6216\u8f7d\u4f53\u4ecb\u5bfc\u7b49\u4e0d\u540c\u6280\u672f\u52a0\u8f7d\u80bf\u7624\u6297\u539f\u3002\u5c06\u8fd9\u4e9b\u7ec6\u80de\u8f93\u6ce8\u5230\u60a3\u8005\u4f53\u5185\u540e\uff0c\u5b83\u4eec\u4f1a\u8fc1\u79fb\u5230\u6dcb\u5df4\u7ed3\uff0c\u5e76\u5c06\u6297\u539f\u5448\u9012\u7ed9\u521d\u59cbT\u6dcb\u5df4\u7ec6\u80de\uff0c\u4ece\u800c\u523a\u6fc0\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\u3002<\/span><\/p>\n<h3><span class=\"ez-toc-section\" id=\"%E7%BB%93%E8%AE%BA\"><\/span><strong><span dir=\"auto\">reach a verdict<\/span><\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span dir=\"auto\">\u6811\u7a81\u72b6<\/span><span dir=\"auto\">\u7ec6\u80de (DC) \u5728\u5efa\u7acb\u514d\u75ab\u5e94\u7b54\u548c\u514d\u75ab\u8010\u53d7\u4e2d\u8d77\u7740\u81f3\u5173\u91cd\u8981\u7684\u4f5c\u7528\u3002\u56e0\u6b64\uff0c\u5b83\u4eec\u4e0e\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u548c\u5176\u4ed6\u75c5\u7406\u72b6\u51b5\u5bc6\u5207\u76f8\u5173\u3002\u76ee\u524d\uff0c\u5bf9\u4e0d\u540c DC \u4e9a\u7fa4\u3001\u5176\u529f\u80fd\u548c\u6cbb\u7597\u5e94\u7528\u7684\u7814\u7a76\u4ecd\u5728\u8fdb\u884c\u4e2d\u3002\u6211\u4eec\u63d0\u4f9b\u6765\u81ea\u4e0d\u540c\u7269\u79cd\u7684 DC\uff0c\u4ee5\u534f\u52a9\u60a8\u7684\u7814\u7a76\u5de5\u4f5c\u3002\u6211\u4eec\u7684\u56e2\u961f\u63d0\u4f9b\u9ad8\u8d28\u91cf\u7684\u6811\u7a81\u72b6\u7ec6\u80de\uff0c\u786e\u4fdd\u5176\u5177\u6709\u6d3b\u6027\u3001\u7eaf\u5ea6\u548c\u529f\u80fd\u6027\u3002<\/span><\/p>\n<h2><span class=\"ez-toc-section\" id=\"%E5%B8%B8%E8%A7%81%E9%97%AE%E9%A2%98%E8%A7%A3%E7%AD%94\"><\/span><strong><span dir=\"auto\">\u5e38\u89c1\u95ee\u9898\u89e3\u7b54<\/span><\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<h3><span class=\"ez-toc-section\" id=\"%E9%97%AE%EF%BC%9A%E6%A0%91%E7%AA%81%E7%8A%B6%E7%BB%86%E8%83%9E%E6%9C%89%E5%93%AA%E4%BA%9B%E5%8A%9F%E8%83%BD%EF%BC%9F\"><\/span><em><strong><span dir=\"auto\">\u95ee\uff1a\u6811\u7a81\u72b6\u7ec6\u80de\u6709\u54ea\u4e9b\u529f\u80fd\uff1f<\/span><\/strong><\/em><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span dir=\"auto\">\u6811\u7a81\u72b6\u7ec6\u80de\u4f5c\u4e3a\u6297\u539f\u5448\u9012\u7ec6\u80de\uff0c\u5c06\u6297\u539f\u5448\u9012\u7ed9T\u6dcb\u5df4\u7ec6\u80de\u3002\u5b83\u4eec\u8fd8\u80fd\u6e05\u9664\u4e0e\u81ea\u8eab\u6297\u539f\u76f8\u4e92\u4f5c\u7528\u7684T\u7ec6\u80de\uff0c\u4ece\u800c\u6709\u52a9\u4e8e\u514d\u75ab\u8010\u53d7\u3002<\/span><\/p>\n<h3><span class=\"ez-toc-section\" id=\"%E9%97%AE%EF%BC%9A%E6%A0%91%E7%AA%81%E7%8A%B6%E7%BB%86%E8%83%9E%E6%9C%89%E5%93%AA%E4%BA%9B%E7%8B%AC%E7%89%B9%E7%89%B9%E5%BE%81%EF%BC%9F\"><\/span><em><strong><span dir=\"auto\">\u95ee\uff1a\u6811\u7a81\u72b6\u7ec6\u80de\u6709\u54ea\u4e9b\u72ec\u7279\u7279\u5f81\uff1f<\/span><\/strong><\/em><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span dir=\"auto\">\u6811\u7a81\u72b6\u7ec6\u80de\u5177\u6709\u72ec\u7279\u7684\u4ea4\u53c9\u5448\u9012\u80fd\u529b\u3002\u5b83\u4eec\u53ef\u4ee5\u5c06\u5916\u6e90\u6027\u6297\u539f\u5448\u9012\u7ed9CD8+ T\u7ec6\u80de\uff08CD8+ T\u7ec6\u80de\u8bc6\u522b\u5185\u6e90\u6027\u6297\u539f\uff09\u3002\u5b83\u4eec\u8fd8\u8fde\u63a5\u9002\u5e94\u6027\u514d\u75ab\u548c\u56fa\u6709\u514d\u75ab\u3002<\/span><\/p>\n<h3><span class=\"ez-toc-section\" id=\"%E9%97%AE%EF%BC%9A%E6%A0%91%E7%AA%81%E7%8A%B6%E7%BB%86%E8%83%9E%E5%A6%82%E4%BD%95%E5%BC%95%E8%B5%B7%E7%A7%BB%E6%A4%8D%E7%89%A9%E6%8A%97%E5%AE%BF%E4%B8%BB%E7%97%85%EF%BC%9F\"><\/span><em><strong><span dir=\"auto\">\u95ee\uff1a\u6811\u7a81\u72b6\u7ec6\u80de\u5982\u4f55\u5f15\u8d77\u79fb\u690d\u7269\u6297\u5bbf\u4e3b\u75c5\uff1f<\/span><\/strong><\/em><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span dir=\"auto\">\u5bbf\u4e3b\u6811\u7a81\u72b6\u7ec6\u80de\u5c06\u5bbf\u4e3b\u6297\u539f\u5448\u9012\u7ed9\u79fb\u690d\u7684\u79fb\u690d\u7269T\u7ec6\u80de\uff0c\u5bfc\u81f4\u79fb\u690d\u7269T\u7ec6\u80de\u5bf9\u5bbf\u4e3b\u4ea7\u751f\u514d\u75ab\u53cd\u5e94\u3002\u8fd9\u4e00\u8fc7\u7a0b\u6700\u7ec8\u5bfc\u81f4\u79fb\u690d\u7269\u6297\u5bbf\u4e3b\u75c5\u3002<\/span><\/p>\n<h3><span class=\"ez-toc-section\" id=\"%E9%97%AE%EF%BC%9A%E6%A0%91%E7%AA%81%E7%8A%B6%E7%BB%86%E8%83%9E%E5%8F%82%E4%B8%8E%E5%93%AA%E4%BA%9B%E4%B8%8D%E5%90%8C%E7%9A%84%E7%96%BE%E7%97%85%EF%BC%9F\"><\/span><em><strong><span dir=\"auto\">\u95ee\uff1a\u6811\u7a81\u72b6\u7ec6\u80de\u53c2\u4e0e\u54ea\u4e9b\u4e0d\u540c\u7684\u75be\u75c5\uff1f<\/span><\/strong><\/em><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span dir=\"auto\">\u6811\u7a81\u72b6\u7ec6\u80de\u7531\u4e8e\u5728\u514d\u75ab\u8010\u53d7\u548cT\u7ec6\u80de\u6d3b\u5316\u4e2d\u53d1\u6325\u91cd\u8981\u4f5c\u7528\uff0c\u56e0\u6b64\u4e0e\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u548c\u764c\u75c7\u6709\u5173\u3002<\/span><\/p>","protected":false},"excerpt":{"rendered":"<p>\u6811\u7a81\u72b6\u7ec6\u80de\u662f\u5177\u6709\u72ec\u7279\u529f\u80fd\u7684\u514d\u75ab\u7ec6\u80de\u3002\u5b83\u4eec\u5177\u5907\u4ea4\u53c9\u5448\u9012\u80fd\u529b\uff0c\u80fd\u591f\u8fde\u63a5\u5148\u5929\u6027\u548c\u9002\u5e94\u6027\u514d\u75ab\u7cfb\u7edf\u3002\u5b83\u4eec\u5728\u514d\u75ab\u53cd\u5e94\u4e2d\u53d1\u6325 [&hellip;]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[78],"tags":[],"_links":{"self":[{"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/posts\/20605"}],"collection":[{"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/comments?post=20605"}],"version-history":[{"count":1,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/posts\/20605\/revisions"}],"predecessor-version":[{"id":20608,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/posts\/20605\/revisions\/20608"}],"wp:attachment":[{"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/media?parent=20605"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/categories?post=20605"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/tags?post=20605"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}