{"id":20609,"date":"2025-11-21T18:01:32","date_gmt":"2025-11-21T10:01:32","guid":{"rendered":"https:\/\/www.hjtdsm.cn\/?p=20609"},"modified":"2025-11-21T18:01:57","modified_gmt":"2025-11-21T10:01:57","slug":"https-www-hjtdsm-cn-stem-cells-ct-20609-html","status":"publish","type":"post","link":"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/ct\/20609.html","title":{"rendered":"\u81ea\u7136\u6740\u4f24\u7ec6\u80de\uff08NK\u7ec6\u80de\uff09\uff1a\u4eba\u4f53\u7684\u514d\u75ab\u54e8\u5175"},"content":{"rendered":"<p><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9905317\/\" target=\"_blank\" rel=\"noopener nofollow\">\u81ea\u7136\u6740\u4f24(NK) \u7ec6\u80de<\/a>\u5728\u80bf\u7624\u76d1\u6d4b\u548c\u62b5\u5fa1\u75c5\u6bd2\u611f\u67d3\u7ec6\u80de\u65b9\u9762\u53d1\u6325\u7740\u81f3\u5173\u91cd\u8981\u7684\u4f5c\u7528\u3002\u5b83\u4eec\u5bf9\u4e8e\u6e05\u9664\u9003\u907fT \u7ec6\u80de\u8bc6\u522b\u7684\u7ec6\u80de\u5185\u75c5\u539f\u4f53\u81f3\u5173\u91cd\u8981\u3002\u4e0eT \u7ec6\u80de\u4e0d\u540c\uff0cNK\u7ec6\u80de\u65e0\u9700\u6fc0\u6d3b\u548c\u9884\u5148\u81f4\u654f\u5373\u53ef\u542f\u52a8\u514d\u75ab\u5e94\u7b54\u3002\u5b83\u4eec\u5728\u80bf\u7624\u3001\u75c5\u6bd2\u611f\u67d3\u3001\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u548c\u708e\u75c7\u6027\u75be\u75c5\u4e2d\u7684\u4f5c\u7528\u5df2\u5f97\u5230\u8bc1\u5b9e\u3002\u56e0\u6b64\uff0c\u76ee\u524d\u6b63\u5728\u7814\u7a76NK \u7ec6\u80de\u7684\u5404\u4e2a\u65b9\u9762\uff0c\u4ee5\u5f00\u53d1\u65b0\u7684\u6cbb\u7597\u65b9\u6cd5\u3002<\/span><\/span><\/span><\/p>\n<div id=\"attachment_20611\" style=\"width: 954px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-20611\" class=\"wp-image-20611 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-21_175713_357.png\" alt=\"\u81ea\u7136\u6740\u4f24\u7ec6\u80de\uff08NK\u7ec6\u80de\uff09\uff1a\u4eba\u4f53\u7684\u514d\u75ab\u54e8\u5175\" width=\"944\" height=\"432\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-21_175713_357.png 944w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-21_175713_357-300x137.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-21_175713_357-768x351.png 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/ScreenShot_2025-11-21_175713_357-18x8.png 18w\" sizes=\"(max-width: 944px) 100vw, 944px\" \/><p id=\"caption-attachment-20611\" class=\"wp-caption-text\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u81ea\u7136\u6740\u4f24\u7ec6\u80de\uff08NK\u7ec6\u80de\uff09\uff1a\u4eba\u4f53\u7684\u514d\u75ab\u54e8\u5175<\/span><\/span><\/p><\/div>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_79_2 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewbox=\"0 0 24 24\" version=\"1.2\" baseprofile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/ct\/20609.html\/#%E8%87%AA%E7%84%B6%E6%9D%80%E4%BC%A4%EF%BC%88NK%EF%BC%89%E7%BB%86%E8%83%9E\" >\u81ea\u7136\u6740\u4f24\uff08NK\uff09\u7ec6\u80de<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/ct\/20609.html\/#NK%E7%BB%86%E8%83%9E%E4%BA%9A%E7%BE%A4\" >NK\u7ec6\u80de\u4e9a\u7fa4<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/ct\/20609.html\/#%E8%AE%B0%E5%BF%86%E6%80%A7NK%E7%BB%86%E8%83%9E\" >\u8bb0\u5fc6\u6027NK\u7ec6\u80de<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/ct\/20609.html\/#%E9%9D%B6%E7%BB%86%E8%83%9E%E8%AF%86%E5%88%AB\" >\u9776\u7ec6\u80de\u8bc6\u522b<\/a><ul class='ez-toc-list-level-4' ><li class='ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/ct\/20609.html\/#%E6%8A%91%E5%88%B6%E6%80%A7%E5%8F%97%E4%BD%93\" >\u6291\u5236\u6027\u53d7\u4f53<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/ct\/20609.html\/#%E6%BF%80%E6%B4%BB%E5%8F%97%E4%BD%93\" >\u6fc0\u6d3b\u53d7\u4f53<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/ct\/20609.html\/#%E5%85%8D%E7%96%AB%E5%8F%8D%E5%BA%94\" >\u514d\u75ab\u53cd\u5e94<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/ct\/20609.html\/#%E6%8A%97%E4%BD%93%E4%BE%9D%E8%B5%96%E6%80%A7%E7%BB%86%E8%83%9E%E6%AF%92%E6%80%A7%EF%BC%88ADCC%EF%BC%89\" >\u6297\u4f53\u4f9d\u8d56\u6027\u7ec6\u80de\u6bd2\u6027\uff08ADCC\uff09<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/ct\/20609.html\/#%E4%B8%B4%E5%BA%8A%E6%84%8F%E4%B9%89\" >\u4e34\u5e8a\u610f\u4e49<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/ct\/20609.html\/#CAR-NK%E7%BB%86%E8%83%9E%E7%96%97%E6%B3%95\" >CAR-NK\u7ec6\u80de\u7597\u6cd5<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/ct\/20609.html\/#%E7%BB%93%E8%AE%BA\" >reach a verdict<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/ct\/20609.html\/#%E5%B8%B8%E8%A7%81%E9%97%AE%E9%A2%98%E8%A7%A3%E7%AD%94\" >\u5e38\u89c1\u95ee\u9898\u89e3\u7b54<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/ct\/20609.html\/#%E9%97%AE%EF%BC%9A%E8%87%AA%E7%84%B6%E6%9D%80%E4%BC%A4%EF%BC%88NK%EF%BC%89%E7%BB%86%E8%83%9E%E5%A6%82%E4%BD%95%E8%AF%86%E5%88%AB%E7%9B%AE%E6%A0%87%EF%BC%9F\" >\u95ee\uff1a\u81ea\u7136\u6740\u4f24\uff08NK\uff09\u7ec6\u80de\u5982\u4f55\u8bc6\u522b\u76ee\u6807\uff1f<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/ct\/20609.html\/#%E9%97%AE%EF%BC%9ANK%E7%BB%86%E8%83%9E%E5%92%8CT%E7%BB%86%E8%83%9E%E6%9C%89%E4%BB%80%E4%B9%88%E5%8C%BA%E5%88%AB%EF%BC%9F\" >\u95ee\uff1aNK\u7ec6\u80de\u548cT\u7ec6\u80de\u6709\u4ec0\u4e48\u533a\u522b\uff1f<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/ct\/20609.html\/#%E9%97%AE%EF%BC%9ANK%E7%BB%86%E8%83%9E%E7%9A%84%E9%9D%B6%E7%BB%86%E8%83%9E%E6%98%AF%E4%BB%80%E4%B9%88%EF%BC%9F\" >\u95ee\uff1aNK\u7ec6\u80de\u7684\u9776\u7ec6\u80de\u662f\u4ec0\u4e48\uff1f<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-16\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/ct\/20609.html\/#%E9%97%AE%EF%BC%9ANK%E7%BB%86%E8%83%9E%E5%A6%82%E4%BD%95%E4%BD%9C%E7%94%A8%E4%BA%8E%E9%9D%B6%E7%BB%86%E8%83%9E%EF%BC%9F\" >\u95ee\uff1aNK\u7ec6\u80de\u5982\u4f55\u4f5c\u7528\u4e8e\u9776\u7ec6\u80de\uff1f<\/a><\/li><\/ul><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"%E8%87%AA%E7%84%B6%E6%9D%80%E4%BC%A4%EF%BC%88NK%EF%BC%89%E7%BB%86%E8%83%9E\"><\/span><b><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u81ea\u7136\u6740\u4f24\uff08NK\uff09\u7ec6\u80de<\/span><\/span><\/span><\/b><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">NK\u7ec6\u80de\u5c5e\u4e8e\u56fa\u6709\u514d\u75ab\u7cfb\u7edf\u3002\u7136\u800c\uff0c\u7531\u4e8e\u5b83\u4eec\u8d77\u6e90\u4e8eNK\u7ec6\u80de\u548cT\u7ec6\u80de\u7684\u5171\u540c\u7956\u7ec6\u80de\uff0c\u56e0\u6b64\u4e5f\u88ab\u5f52\u7c7b\u4e3a\u6dcb\u5df4\u7ec6\u80de\u3002\u6240\u4ee5\uff0c\u81ea\u7136\u6740\u4f24\u7ec6\u80de\u4e5f\u88ab\u79f0\u4e3a\u56fa\u6709\u514d\u75ab\u7cfb\u7edf\u7684\u7ec6\u80de\u6bd2\u6027\u6dcb\u5df4\u7ec6\u80de\u3002\u5b83\u4eec\u7684\u9776\u7ec6\u80de\u5305\u62ec\u53d7\u635f\u7ec6\u80de\uff0c\u4f8b\u5982\u611f\u67d3\u7ec6\u80de\u6216\u80bf\u7624\u7ec6\u80de\u3002 NK\u7ec6\u80de\u7531\u9aa8\u9ad3\u4e2d<\/span><\/span><\/span><strong><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7684<a href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-transplantation\/19749.html\/\" target=\"_blank\" rel=\"noopener\">blood generating stem cells (in bone marrow)<\/a><\/span><\/span><\/span><\/strong><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff08HSC\uff09\u5206\u5316\u800c\u6765\uff0c\u5e76\u53ef\u5728\u9aa8\u9ad3\u6216\u6b21\u7ea7\u6dcb\u5df4\u7ec4\u7ec7\u4e2d\u6210\u719f\u3002 NK\u7ec6\u80de\u4e5f\u53ef\u4ece\u60a3\u8005\u7684\u5916\u5468\u8840\u4e2d\u5206\u79bb\u63d0\u53d6\u3002 NK\u7ec6\u80de\u7ea6\u5360\u5916\u5468\u8840\u6dcb\u5df4\u7ec6\u80de\u603b\u6570\u76842%\u81f318%\u3002\u00a0<\/span><\/span><\/span><\/p>\n<h3><span class=\"ez-toc-section\" id=\"NK%E7%BB%86%E8%83%9E%E4%BA%9A%E7%BE%A4\"><\/span><b><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">NK\u7ec6\u80de\u4e9a\u7fa4<\/span><\/span><\/span><\/b><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">NK\u7ec6\u80de\u662f\u4e00\u7c7b\u5927\u578b\u9897\u7c92\u72b6\u767d\u7ec6\u80de\uff0c\u5176\u7279\u5f81\u662fCD56\u548cCD16\u9633\u6027\u8868\u8fbe\uff0cCD3\u548cT\u7ec6\u80de\u53d7\u4f53\uff08TCR\uff09\u9634\u6027\u8868\u8fbe\u3002\u6839\u636eCD56\u6807\u5fd7\u7269\u7684\u8868\u8fbe\u60c5\u51b5\uff0cNK\u7ec6\u80de\u5927\u81f4\u53ef\u5206\u4e3a\u4e24\u7c7b\uff1aCD56<\/span><\/span><\/span><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u9ad8\u8868\u8fbe\u4e9a\u7fa4<\/span><\/span><\/span><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u548cCD56<\/span><\/span><\/span><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4f4e\u8868<\/span><\/span><\/span><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8fbe\u4e9a\u7fa4\u3002 CD56<\/span><\/span><\/span><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4f4e\u8868<\/span><\/span><\/span><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8fbe\u4e9a\u7fa4\u4e5f\u8868\u8fbeCD16\uff0c\u5e76\u542b\u6709\u7a7f\u5b54\u7d20\uff0c\u7a7f\u5b54\u7d20\u662f\u5176\u7ec6\u80de\u6bd2\u6d3b\u6027\u6240\u5fc5\u9700\u7684\u3002 CD56<\/span><\/span><\/span><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u9ad8\u8868<\/span><\/span><\/span><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8fbe\u4e9a\u7fa4\u4ea7\u751f\u7ec6\u80de\u56e0\u5b50\uff0c\u4f46\u4e0d\u8868\u8fbe\u7a7f\u5b54\u7d20\u548cCD16\u3002 CD56<\/span><\/span><\/span><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4f4e<\/span><\/span><\/span><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8868\u8fbe\u4e9a\u7fa4\u5360<\/span><\/span><\/span><strong><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5916\u5468\u8840NK\u7ec6\u80de<\/span><\/span><\/span><\/strong><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u768490% \u3002\u76ee\u524d\uff0c\u5df2\u9274\u5b9a\u51fa\u66f4\u591a\u4e9a\u7fa4\u3002\u4f8b\u5982\uff0c\u5728HIV\u548c\u4e59\u578b\u809d\u708e\u75c5\u6bd2\u611f\u67d3\u671f\u95f4\u5b58\u5728\u7684CD56<\/span><\/span><\/span><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u9634\u6027<\/span><\/span><\/span><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e9a\u7fa4\uff0c\u4ee5\u53ca\u80ba\u548c\u809d\u810f\u4e2d\u7684\u7ec4\u7ec7\u9a7b\u7559NK\u7ec6\u80de\u4e9a\u7fa4\u3002\u7ec4\u7ec7\u9a7b\u7559NK\u7ec6\u80de\u5177\u6709\u4e00\u7ec4\u72ec\u7279\u7684\u8bc6\u522b\u6807\u5fd7\u7269\uff0c\u4f8b\u5982CD103\u3001CD69\u548cCD49a\u3002\u8fd9\u4e9b\u7ec4\u7ec7\u9a7b\u7559NK\u7ec6\u80de\u5728\u8868\u578b\u548c\u529f\u80fd\u4e0a\u4e5f\u4e0e\u5faa\u73af\u4e2d\u7684NK\u7ec6\u80de\u6709\u6240\u4e0d\u540c\u3002<\/span><\/span><\/span><\/p>\n<h3><span class=\"ez-toc-section\" id=\"%E8%AE%B0%E5%BF%86%E6%80%A7NK%E7%BB%86%E8%83%9E\"><\/span><b><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8bb0\u5fc6\u6027NK\u7ec6\u80de<\/span><\/span><\/span><\/b><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e0e\u9002\u5e94\u6027\u514d\u75ab\u7ec6\u80de\u7c7b\u4f3c\uff0cNK\u7ec6\u80de\u4e5f\u5177\u6709\u514d\u75ab\u8bb0\u5fc6\u3002\u8bb0\u5fc6\u6027NK\u7ec6\u80de\u5bf9\u7279\u5b9a\u6297\u539f\u5177\u6709\u9ad8\u5ea6\u6fc0\u6d3b\u80fd\u529b\uff0c\u5e76\u80fd\u957f\u671f\u5b58\u6d3b\u3002 NKG2C\u00a0 <\/span><\/span><\/span><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">+<\/span><\/span><\/span><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7ec6\u80de\u5c31\u662f\u8bb0\u5fc6\u6027NK\u7ec6\u80de\u7684\u5178\u578b\u4f8b\u5b50\u3002\u6709\u8da3\u7684\u662f\uff0c\u4e0d\u4ec5\u6297\u539f\uff0c\u7ec6\u80de\u56e0\u5b50\u4e5f\u80fd\u8bf1\u5bfcNK\u7ec6\u80de\u4ea7\u751f\u514d\u75ab\u8bb0\u5fc6\u3002\u7814\u7a76\u8868\u660e\uff0c\u4e0e\u75c5\u6bd2\u6216\u534a\u6297\u539f\u8bf1\u5bfc\u7684\u8bb0\u5fc6\u6027NK\u7ec6\u80de\u76f8\u6bd4\uff0c\u7ec6\u80de\u56e0\u5b50\u8bf1\u5bfc\u7684\u8bb0\u5fc6\u6027NK\u7ec6\u80de\u5177\u6709\u66f4\u9ad8\u7684\u518d\u6fc0\u6d3b\u6f5c\u80fd\uff0c\u5e76\u4e14\u80fd\u591f\u5bf9\u591a\u79cd\u523a\u6fc0\u505a\u51fa\u53cd\u5e94\u3002<\/span><\/span><\/span><\/p>\n<h3><span class=\"ez-toc-section\" id=\"%E9%9D%B6%E7%BB%86%E8%83%9E%E8%AF%86%E5%88%AB\"><\/span><b><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u9776\u7ec6\u80de\u8bc6\u522b<\/span><\/span><\/span><\/b><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">NK\u7ec6\u80de\u8bc6\u522b\u9776\u7ec6\u80de\u7684\u8fc7\u7a0b\u4e0eT\u7ec6\u80de\u4e0d\u540c\u3002 T\u7ec6\u80de\u8bc6\u522b\u7531\u6297\u539f\u5448\u9012\u7ec6\u80de\u5448\u9012\u7684\u6297\u539f\uff0c\u800c\u5176\u4ed6\u514d\u75ab\u7ec6\u80de\u5219\u8bc6\u522b\u75c5\u539f\u4f53\u4e0a\u8fdb\u5316\u4fdd\u5b88\u7684\u533a\u57df\u3002\u7136\u800c\uff0cNK\u7ec6\u80de\u5177\u6709\u901a\u8fc7\u81ea\u8eab\u5206\u5b50\u6c34\u5e73\u8bc6\u522b\u9776\u7ec6\u80de\u7684\u72ec\u7279\u80fd\u529b\u3002\u4e24\u79cd\u4e0d\u540c\u7684\u53d7\u4f53\u2014\u2014\u6291\u5236\u6027\u53d7\u4f53\u548c\u6fc0\u6d3b\u6027\u53d7\u4f53\u2014\u2014\u4e25\u683c\u8c03\u63a7\u9776\u7ec6\u80de\u7684\u8bc6\u522b\u4ee5\u53ca\u968f\u540e\u5bf9\u5f02\u5e38\u7ec6\u80de\u7684\u88c2\u89e3\u3002<\/span><\/span><\/span><\/p>\n<h4><span class=\"ez-toc-section\" id=\"%E6%8A%91%E5%88%B6%E6%80%A7%E5%8F%97%E4%BD%93\"><\/span><b><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6291\u5236\u6027\u53d7\u4f53<\/span><\/span><\/span><\/b><span class=\"ez-toc-section-end\"><\/span><\/h4>\n<p><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5065\u5eb7\u7ec6\u80de\u4f1a\u7ec4\u6210\u6027\u8868\u8fbe\u67d0\u4e9b\u81ea\u8eab\u5206\u5b50\uff0c\u4f8b\u5982\u4e3b\u8981\u7ec4\u7ec7\u76f8\u5bb9\u6027\u590d\u5408\u4f53(MHC) I\u3002\u6291\u5236\u6027\u53d7\u4f53\u80fd\u591f\u611f\u77e5\u8fd9\u4e9b\u5206\u5b50\u7684\u6c34\u5e73\u3002\u53d7\u4f53\u4e0e\u81ea\u8eab\u5206\u5b50\u7684\u76f8\u4e92\u4f5c\u7528\u4f1a\u5411\u53d7\u4f53\u7684\u514d\u75ab\u53d7\u4f53\u916a\u6c28\u9178\u6291\u5236\u57fa\u5e8f(ITIM) \u53d1\u51fa\u4fe1\u53f7\uff0c\u4ece\u800c\u6fc0\u6d3b\u78f7\u9178\u9176SHP1 \u548cSHP2\u3002 SHP1 \u548cSHP2 \u4f1a\u6291\u5236\u57fa\u4e8e\u6fc0\u9176\u7684\u6fc0\u6d3b\u4fe1\u53f7\uff0c\u8fdb\u800c\u5411\u7ec6\u80de\u88c2\u89e3\u8fc7\u7a0b\u53d1\u51fa\u6291\u5236\u4fe1\u53f7\uff08\u56fe1A\uff09\u3002\u56e0\u6b64\uff0cNK \u7ec6\u80de\u4f1a\u4e0e\u5065\u5eb7\u7ec6\u80de\u8131\u79bb\u3002\u7136\u800c\uff0c\u5f53\u8fd9\u4e9b\u53d7\u4f53\u611f\u77e5\u5230\u9776\u7ec6\u80de\u4e0a\u81ea\u8eab\u5206\u5b50\u7684\u8868\u8fbe\u4e0b\u8c03\u65f6\uff0cNK \u7ec6\u80de\u5c31\u4f1a\u5931\u53bb\u6291\u5236\u4fe1\u53f7\u3002\u6740\u4f24\u7ec6\u80de\u514d\u75ab\u7403\u86cb\u767d\u6837\u53d7\u4f53(KIR)\u3001NKG2A\uff08C \u578b\u51dd\u96c6\u7d20\u53d7\u4f53\uff09\u548c\u767d\u7ec6\u80de\u6291\u5236\u6027\u53d7\u4f531 (LIR1) \u5c31\u662f\u8fd9\u4e9b\u53d7\u4f53\u7684\u51e0\u4e2a\u4f8b\u5b50\u3002 KIR \u8bc6\u522b\u7ec6\u80de\u4e0a\u7684MHC I\u3002<\/span><\/span><\/span><\/p>\n<h4><span class=\"ez-toc-section\" id=\"%E6%BF%80%E6%B4%BB%E5%8F%97%E4%BD%93\"><\/span><b><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6fc0\u6d3b\u53d7\u4f53<\/span><\/span><\/span><\/b><span class=\"ez-toc-section-end\"><\/span><\/h4>\n<p><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5f02\u5e38\u7ec6\u80de\uff0c\u5305\u62ec\u611f\u67d3\u7ec6\u80de\u548c\u80bf\u7624\u7ec6\u80de\uff0c\u901a\u8fc7\u4e0b\u8c03MHC I\u7c7b\u5206\u5b50\u7684\u8868\u8fbe\u6765\u9003\u907fT\u7ec6\u80de\u7684\u8bc6\u522b\uff0c\u4f46\u81ea\u7136\u6740\u4f24\u7ec6\u80de\uff08NK\u7ec6\u80de\uff09\u80fd\u591f\u8bc6\u522b\u8fd9\u79cd\u4e0b\u8c03\u3002\u8fd9\u88ab\u79f0\u4e3a\u8bf1\u5bfc\u81ea\u8eab\u8bc6\u522b\u3002\u7531\u4e8e\u4e0e\u9776\u7ec6\u80de\u4e0a\u7684\u81ea\u8eab\u5206\u5b50\u53d1\u751f\u9608\u4e0b\u76f8\u4e92\u4f5c\u7528\uff0c\u6291\u5236\u4fe1\u53f7\u7684\u7f3a\u5931\u963b\u6b62\u4e86\u6fc0\u6d3b\u53d7\u4f53\u7684\u6291\u5236\uff0c\u8fdb\u800c\u523a\u6fc0\u7ec6\u80de\u88c2\u89e3\u8fc7\u7a0b\uff08\u56fe1B\uff09\u3002\u8fd9\u4e5f\u88ab\u79f0\u4e3a\u201c\u7f3a\u5931\u81ea\u8eab\u5047\u8bf4\u201d\u3002 NK\u7ec6\u80de\u4e0a\u5b58\u5728\u591a\u79cd\u6fc0\u6d3b\u53d7\u4f53\uff0c\u4f8b\u5982\u5929\u7136\u7ec6\u80de\u6bd2\u6027\u53d7\u4f53\uff08NCR\uff09\u3001NK2D\u3001CD16\u7b49\u3002\u7814\u7a76\u8868\u660e\uff0c\u9664CD16\u53d7\u4f53\u4fe1\u53f7\u5916\uff0cNK\u7ec6\u80de\u9700\u8981\u591a\u79cd\u6fc0\u6d3b\u4fe1\u53f7\u624d\u80fd\u542f\u52a8\u7ec6\u80de\u88c2\u89e3\u3002<\/span><\/span><\/span><\/p>\n<div id=\"attachment_20610\" style=\"width: 860px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-20610\" class=\"wp-image-20610 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5fae\u4fe1\u56fe\u7247_2025-11-21_175404_673.png\" alt=\"\" width=\"850\" height=\"754\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5fae\u4fe1\u56fe\u7247_2025-11-21_175404_673.png 850w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5fae\u4fe1\u56fe\u7247_2025-11-21_175404_673-300x266.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5fae\u4fe1\u56fe\u7247_2025-11-21_175404_673-768x681.png 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/11\/\u5fae\u4fe1\u56fe\u7247_2025-11-21_175404_673-14x12.png 14w\" sizes=\"(max-width: 850px) 100vw, 850px\" \/><p id=\"caption-attachment-20610\" class=\"wp-caption-text\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u56fe1. NK\u7ec6\u80de\u8bc6\u522b\u9776\u7ec6\u80de\u5e76\u88c2\u89e3\u9776\u7ec6\u80de\u7684\u8fc7\u7a0b\u3002 A. NK\u7ec6\u80de\u7684\u6291\u5236\u6027\u53d7\u4f53\u4e0e\u5065\u5eb7\u7ec6\u80de\u4e0a\u7684MHC I\u7c7b\u5206\u5b50\u76f8\u4e92\u4f5c\u7528\uff0c\u4ece\u800c\u6291\u5236NK\u7ec6\u80de\u7684\u514d\u75ab\u5e94\u7b54\u3002 B. \u80bf\u7624\u7ec6\u80de\u4e0aMHC I\u7c7b\u5206\u5b50\u7684\u4e0b\u8c03\u51cf\u5f31\u4e86\u6291\u5236\u4fe1\u53f7\uff0c\u6fc0\u6d3b\u6027\u53d7\u4f53\u901a\u8fc7\u9176\uff08\u7a7f\u5b54\u7d20\u548c\u9897\u7c92\u9176\uff09\u3001\u914d\u4f53\uff08FasL\u548cTRAIL\uff09\u4ee5\u53ca\u7ec6\u80de\u56e0\u5b50\u523a\u6fc0NK\u7ec6\u80de\u7684\u514d\u75ab\u5e94\u7b54\u3002 C. NK\u7ec6\u80de\u7684CD16\u6fc0\u6d3b\u6027\u53d7\u4f53\u4e0e\u7ed3\u5408\u5728\u80bf\u7624\u7ec6\u80de\u4e0a\u7684\u6297\u4f53\u76f8\u4e92\u4f5c\u7528\uff0c\u5bfc\u81f4\u80bf\u7624\u7ec6\u80de\u88c2\u89e3\uff0c\u4e5f\u79f0\u4e3a\u6297\u4f53\u4f9d\u8d56\u6027\u7ec6\u80de\u6bd2\u6027\uff08ADCC\uff09\u3002<\/span><\/span><\/p><\/div>\n<figure id=\"attachment_31340\" class=\"wp-caption aligncenter\" aria-describedby=\"caption-attachment-31340\"><\/figure>\n<h3><span class=\"ez-toc-section\" id=\"%E5%85%8D%E7%96%AB%E5%8F%8D%E5%BA%94\"><\/span><strong><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u514d\u75ab\u53cd\u5e94<\/span><\/span><\/span><\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">NK\u7ec6\u80de\u901a\u8fc7\u4e24\u79cd\u4e0d\u540c\u7684\u65b9\u5f0f\u4ecb\u5bfc\u514d\u75ab\u53cd\u5e94\uff08\u56fe1B\uff09\uff1a<\/span><\/span><\/span><\/p>\n<p><strong><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7ec6\u80de\u6bd2\u6027<\/span><\/span><\/span><\/strong><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff1aNK\u7ec6\u80de\u6d3b\u5316\u540e\uff0c\u4f1a\u91ca\u653e\u542b\u6709\u7a7f\u5b54\u7d20\u548c\u9897\u7c92\u9176\uff08\u86cb\u767d\u9176\uff09\u7684\u9897\u7c92\uff0c\u7a7f\u5b54\u7d20\u53ef\u7834\u574f\u9776\u7ec6\u80de\u819c\u3002\u8fd9\u4e9b\u9897\u7c92\u5171\u540c\u8bf1\u5bfc\u9776\u7ec6\u80de\u51cb\u4ea1\u3002\u6b64\u5916\uff0cNK\u7ec6\u80de\u8fd8\u643a\u5e26Fas\u914d\u4f53\uff08FasL\uff09\u548c\u80bf\u7624\u574f\u6b7b\u56e0\u5b50\u76f8\u5173\u51cb\u4ea1\u8bf1\u5bfc\u914d\u4f53\uff08TRAIL\uff09\uff0c\u5b83\u4eec\u5728\u9776\u7ec6\u80de\u4e0a\u5177\u6709\u76f8\u5e94\u7684\u53d7\u4f53\u3002\u5b83\u4eec\u7684\u76f8\u4e92\u4f5c\u7528\u4f1a\u5bfc\u81f4caspase\u4f9d\u8d56\u6027\u51cb\u4ea1\u3002<\/span><\/span><\/span><\/p>\n<p><strong><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6548\u5e94\u529f\u80fd<\/span><\/span><\/span><\/strong><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff1aNK \u7ec6\u80de\u8fd8\u901a\u8fc7\u5206\u6cccIFN\u03b3\u3001TNF\u03b1\u3001IL10 \u7b49\u7ec6\u80de\u56e0\u5b50\u6765\u53d1\u6325\u6548\u5e94\u529f\u80fd\u3002\u8fd9\u4e9b\u7ec6\u80de\u56e0\u5b50\u5e2e\u52a9NK \u7ec6\u80de\u52df\u96c6\u66f4\u591a\u514d\u75ab\u7ec6\u80de\u5230\u611f\u67d3\u90e8\u4f4d\uff0c\u5e76\u4e0a\u8c03\u9776\u7ec6\u80de\u4e0a\u7684MHC I \u8868\u8fbe\u4ee5\u6fc0\u6d3bT \u7ec6\u80de\u3002<\/span><\/span><\/span><\/p>\n<h3><span class=\"ez-toc-section\" id=\"%E6%8A%97%E4%BD%93%E4%BE%9D%E8%B5%96%E6%80%A7%E7%BB%86%E8%83%9E%E6%AF%92%E6%80%A7%EF%BC%88ADCC%EF%BC%89\"><\/span><strong><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6297\u4f53\u4f9d\u8d56\u6027\u7ec6\u80de\u6bd2\u6027\uff08ADCC\uff09<\/span><\/span><\/span><\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6297\u4f53\u4f9d\u8d56\u6027\u7ec6\u80de\u4ecb\u5bfc\u7684\u7ec6\u80de\u6bd2\u6027\u4f5c\u7528\uff08ADCC\uff09\u662f\u6307\u6297\u4f53\u5c06\u75c5\u539f\u4f53\u6216\u75c5\u539f\u4f53\u611f\u67d3\u7684\u7ec6\u80de\u4e0e\u6548\u5e94\u7ec6\u80de\u8fde\u63a5\u8d77\u6765\u7684\u8fc7\u7a0b\u3002\u6297\u4f53\u7684Fab\u7247\u6bb5\u4e0e\u6297\u539f\u7ed3\u5408\uff0c\u800c\u5176Fc\u7247\u6bb5\u4e0e\u514d\u75ab\u7ec6\u80de\u76f8\u4e92\u4f5c\u7528\u3002\u8fd9\u4e9b\u514d\u75ab\u7ec6\u80de\u8868\u8fbe\u6297\u4f53Fc\u533a\u7684\u53d7\u4f53\uff0c\u5305\u62ecNK\u7ec6\u80de\u3001\u5de8\u566c\u7ec6\u80de\u3001\u6811\u7a81\u72b6\u7ec6\u80de\u3001\u55dc\u9178\u6027\u7c92\u7ec6\u80de\u7b49\u3002 NK\u7ec6\u80de\u901a\u8fc7\u5176\u6fc0\u6d3b\u53d7\u4f53Fc\u03b3RIII\uff08CD16\uff09\u4f5c\u4e3a\u6548\u5e94\u7ec6\u80de\u53c2\u4e0eADCC\u3002\u7ed3\u5408\u540e\uff0cNK\u7ec6\u80de\u542f\u52a8\u9776\u7ec6\u80de\u7684\u88c2\u89e3\uff08\u56fe1C\uff09\u3002<\/span><\/span><\/span><\/p>\n<h3><span class=\"ez-toc-section\" id=\"%E4%B8%B4%E5%BA%8A%E6%84%8F%E4%B9%89\"><\/span><strong><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e34\u5e8a\u610f\u4e49<\/span><\/span><\/span><\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4f5c\u4e3a\u56fa\u6709\u514d\u75ab\u7ec6\u80de\uff0cNK\u7ec6\u80de\u662f\u62b5\u5fa1\u75c5\u539f\u4f53\u5165\u4fb5\u7ec6\u80de\u7684\u7b2c\u4e00\u9053\u9632\u7ebf\u3002\u5c0f\u9f20\u6a21\u578b\u7814\u7a76\u8868\u660e\uff0cNK\u7ec6\u80de\u8017\u7aed\u6216\u7f3a\u9677\u4f1a\u589e\u52a0\u80bf\u7624\u548c\u75c5\u6bd2\u611f\u67d3\uff08\u5c24\u5176\u662f\u75b1\u75b9\u75c5\u6bd2\uff09\u7684\u6613\u611f\u6027\u3002\u79d1\u5b66\u5bb6\u8fd8\u53d1\u73b0\uff0cNK\u7ec6\u80de\u6d3b\u6027\u4f4e\u4e0b\u4e0e\u764c\u75c7\u98ce\u9669\u589e\u52a0\u76f8\u5173\u3002\u4e00\u9879\u7814\u7a76\u751a\u81f3\u8868\u660e\uff0c\u79fb\u690d\u8fc7\u7a0b\u4e2d\u4f9b\u4f53\u548c\u53d7\u4f53\u4e4b\u95f4KIR\u57fa\u56e0\u7684\u4e0d\u5339\u914d\u53ef\u4ee5\u6d88\u9664\u767d\u8840\u75c5\u3001\u79fb\u690d\u7269\u6297\u5bbf\u4e3b\u75c5\u548c\u79fb\u690d\u6392\u65a5\u53cd\u5e94\u3002<\/span><\/span><\/span><\/p>\n<h3><span class=\"ez-toc-section\" id=\"CAR-NK%E7%BB%86%E8%83%9E%E7%96%97%E6%B3%95\"><\/span><strong><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">CAR-NK\u7ec6\u80de\u7597\u6cd5<\/span><\/span><\/span><\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e0e\u5d4c\u5408\u6297\u539f\u53d7\u4f53\uff08CAR\uff09T\u7ec6\u80de\u7597\u6cd5\u7c7b\u4f3c\uff0c\u79d1\u5b66\u5bb6\u4eec\u901a\u8fc7\u6539\u9020NK\u7ec6\u80de\u7684\u53d7\u4f53\uff0c\u5f00\u53d1\u51fa\u4e86CAR NK\u7ec6\u80de\u7597\u6cd5\uff0c\u7528\u4e8e\u5bf9\u6297\u764c\u7ec6\u80de\u3002\u8fd9\u79cd\u6539\u9020\u540e\u7684\u53d7\u4f53\u7ed3\u5408\u4e86NK\u7ec6\u80de\u7684\u80de\u5185\u533a\u548cscFv\u7247\u6bb5\u7684\u80de\u5916\u533a\uff0cscFv\u7247\u6bb5\u662f\u6297\u4f53\u7684\u6297\u539f\u7ed3\u5408\u57df\u3002\u4e0eCAR T\u7ec6\u80de\u7597\u6cd5\u4e0d\u540c\uff0cNK\u7ec6\u80de\u65e0\u9700\u9884\u5148\u81f4\u654f\u6297\u539f\uff0c\u56e0\u6b64\u53ef\u4ee5\u63d0\u524d\u5236\u5907\u3002\u6b64\u5916\uff0cNK\u7ec6\u80de\u7684\u514d\u75ab\u6392\u65a5\u98ce\u9669\u8f83\u4f4e\uff0c\u4f7f\u5176\u53ef\u4ee5\u4ece\u4e0d\u540c\u7684\u7ec4\u7ec7\u548c\u6765\u6e90\u4e2d\u63d0\u53d6\u3002 CAR NK\u7ec6\u80de\u7597\u6cd5\u7684\u521d\u6b65\u7ed3\u679c\u663e\u793a\uff0c\u5176\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u4ee4\u4eba\u9f13\u821e\u3002\u76ee\u524d\uff0c\u7814\u7a76\u4eba\u5458\u6b63\u7ee7\u7eed\u671d\u7740\u8fd9\u4e2a\u65b9\u5411\u52aa\u529b\uff0c\u4ee5\u6539\u8fdb\u6539\u9020\u540e\u7684\u53d7\u4f53\u7ed3\u6784\uff0c\u5e76\u514b\u670d\u80bf\u7624\u5fae\u73af\u5883\uff08TME\uff09\u5bf9NK\u7ec6\u80de\u6d3b\u6027\u7684\u6291\u5236\u4f5c\u7528\u3002<\/span><\/span><\/span><\/p>\n<h2><span class=\"ez-toc-section\" id=\"%E7%BB%93%E8%AE%BA\"><\/span><strong><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">reach a verdict<\/span><\/span><\/span><\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">NK\u7ec6\u80de\u662f\u514d\u75ab\u7cfb\u7edf\u4e2d\u6700\u72ec\u7279\u7684\u7ec6\u80de\uff0c\u5b83\u4eec\u80fd\u591f\u8bc6\u522b\u81ea\u8eab\u7ec6\u80de\u8868\u9762\u7684\u5206\u5b50\u6c34\u5e73\uff0c\u800c\u975e\u75c5\u539f\u4f53\u3002 NK\u7ec6\u80de\u65e0\u9700\u6fc0\u6d3b\u5373\u53ef\u542f\u52a8\u514d\u75ab\u53cd\u5e94\uff0c\u65e0\u9700\u4e8b\u5148\u523a\u6fc0\u3002\u79d1\u5b66\u5bb6\u4eec\u4e00\u76f4\u5728\u5229\u7528NK\u7ec6\u80de\u7684\u8fd9\u4e9b\u7279\u6027\u8fdb\u884c\u6cbb\u7597\u5e72\u9884\u3002\u6301\u7eed\u7684\u7814\u7a76\u4e5f\u63ed\u793a\u4e86NK\u7ec6\u80de\u5728\u591a\u79cd\u75be\u75c5\u4e2d\u7684\u4f5c\u7528\u3002\u676d\u5409\u5e72\u7ec6\u80de\u79d1\u6280\u63d0\u4f9b\u6e90\u81ea\u4e0d\u540c\u7269\u79cd\u9aa8\u9ad3\u548c\u5916\u5468\u8840\u7684NK\u7ec6\u80de\u3002\u6211\u4eec\u7684<\/span><\/span><\/span><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u56e2\u961f<\/span><\/span><\/span><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5bf9\u8fd9\u4e9b\u7ec6\u80de\u8fdb\u884c\u4e25\u683c\u7684\u68c0\u6d4b\uff0c\u4ee5\u786e\u4fdd\u5176\u7eaf\u5ea6\u3001\u65e0\u83cc\u6027\u3001\u6d3b\u6027\u548c\u529f\u80fd\u6027\u3002<\/span><\/span><\/span><\/p>\n<h2><span class=\"ez-toc-section\" id=\"%E5%B8%B8%E8%A7%81%E9%97%AE%E9%A2%98%E8%A7%A3%E7%AD%94\"><\/span><strong><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5e38\u89c1\u95ee\u9898\u89e3\u7b54<\/span><\/span><\/span><\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<h3><span class=\"ez-toc-section\" id=\"%E9%97%AE%EF%BC%9A%E8%87%AA%E7%84%B6%E6%9D%80%E4%BC%A4%EF%BC%88NK%EF%BC%89%E7%BB%86%E8%83%9E%E5%A6%82%E4%BD%95%E8%AF%86%E5%88%AB%E7%9B%AE%E6%A0%87%EF%BC%9F\"><\/span><em><strong><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u95ee\uff1a\u81ea\u7136\u6740\u4f24\uff08NK\uff09\u7ec6\u80de\u5982\u4f55\u8bc6\u522b\u76ee\u6807\uff1f<\/span><\/span><\/span><\/strong><\/em><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">NK\u7ec6\u80de\u901a\u8fc7\u6291\u5236\u6027\u53d7\u4f53\u611f\u77e5\u7ec6\u80de\u8868\u9762\u81ea\u8eab\u5206\u5b50\uff08\u5982MHC I\u7c7b\u5206\u5b50\uff09\u7684\u6c34\u5e73\u3002 NK\u7ec6\u80de\u901a\u8fc7\u8fd9\u4e9b\u53d7\u4f53\u4e0e\u5176\u4ed6\u7ec6\u80de\u76f8\u4e92\u4f5c\u7528\u3002\u5065\u5eb7\u7ec6\u80de\u4e0a\u9002\u91cf\u7684\u8fd9\u4e9b\u5206\u5b50\u4f1a\u542f\u52a8\u6291\u5236\u4fe1\u53f7\uff0c\u4ece\u800c\u963b\u6b62NK\u7ec6\u80de\u7684\u7ec6\u80de\u6bd2\u6027\u3002\u4f46\u80de\u5185\u75c5\u539f\u4f53\u548c\u80bf\u7624\u7ec6\u80de\u4f1a\u4e0b\u8c03\u8fd9\u4e9b\u5206\u5b50\u7684\u8868\u8fbe\uff0c\u5bfc\u81f4\u7ec6\u80de\u8868\u9762\u81ea\u8eab\u5206\u5b50\u6c34\u5e73\u964d\u4f4e\uff0c\u6291\u5236\u4fe1\u53f7\u51cf\u5f31\u3002\u6fc0\u6d3b\u4fe1\u53f7\u4e0d\u518d\u53d7\u5230\u6291\u5236\uff0c\u6700\u7ec8\u5bfc\u81f4NK\u7ec6\u80de\u7684\u7ec6\u80de\u6bd2\u6027\u3002<\/span><\/span><\/span><\/p>\n<h3><span class=\"ez-toc-section\" id=\"%E9%97%AE%EF%BC%9ANK%E7%BB%86%E8%83%9E%E5%92%8CT%E7%BB%86%E8%83%9E%E6%9C%89%E4%BB%80%E4%B9%88%E5%8C%BA%E5%88%AB%EF%BC%9F\"><\/span><em><strong><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u95ee\uff1aNK\u7ec6\u80de\u548cT\u7ec6\u80de\u6709\u4ec0\u4e48\u533a\u522b\uff1f<\/span><\/span><\/span><\/strong><\/em><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">NK\u7ec6\u80de\u4e0d\u5177\u5907T\u7ec6\u80de\u7684\u6297\u539f\u7279\u5f02\u6027\u3002\u4e0eT\u7ec6\u80de\u4e0d\u540c\uff0cNK\u7ec6\u80de\u4e0d\u9700\u8981\u9884\u5148\u4e0e\u6297\u539f\u76f8\u4e92\u4f5c\u7528\u3002\u5b83\u4eec\u4e0d\u50cfT\u7ec6\u80de\u90a3\u6837\u8bc6\u522b\u6297\u539f\u5206\u5b50\uff0c\u800c\u662f\u8bc6\u522b\u7ec4\u6210\u578b\u6807\u5fd7\u7269\u7684\u4e0b\u8c03\u3002\u7531\u4e8eNK\u7ec6\u80de\u4e0d\u9700\u8981\u6fc0\u6d3b\uff0c\u56e0\u6b64\u5176\u514d\u75ab\u5e94\u7b54\u6bd4T\u7ec6\u80de\u66f4\u5feb\u3002<\/span><\/span><\/span><\/p>\n<h3><span class=\"ez-toc-section\" id=\"%E9%97%AE%EF%BC%9ANK%E7%BB%86%E8%83%9E%E7%9A%84%E9%9D%B6%E7%BB%86%E8%83%9E%E6%98%AF%E4%BB%80%E4%B9%88%EF%BC%9F\"><\/span><em><strong><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u95ee\uff1aNK\u7ec6\u80de\u7684\u9776\u7ec6\u80de\u662f\u4ec0\u4e48\uff1f<\/span><\/span><\/span><\/strong><\/em><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">NK\u7ec6\u80de\u4f5c\u7528\u4e8e\u88ab\u75c5\u539f\u4f53\u611f\u67d3\u7684\u7ec6\u80de\u4ee5\u53ca\u5176\u4ed6\u5f02\u5e38\u7ec6\u80de\uff0c\u4f8b\u5982\u80bf\u7624\u7ec6\u80de\u3002\u8fd9\u4e9b\u5f02\u5e38\u7ec6\u80de\u4f1a\u4e0b\u8c03MHC I\u7c7b\u5206\u5b50\u7684\u8868\u8fbe\u4ee5\u9003\u907fT\u7ec6\u80de\u7684\u653b\u51fb\u3002\u7136\u800c\uff0cNK\u7ec6\u80de\u80fd\u591f\u8bc6\u522b\u8fd9\u4e9b\u4e0b\u8c03\u7684\u5206\u5b50\uff0c\u5e76\u542f\u52a8\u76f8\u5e94\u7684\u514d\u75ab\u53cd\u5e94\u3002<\/span><\/span><\/span><\/p>\n<h3><span class=\"ez-toc-section\" id=\"%E9%97%AE%EF%BC%9ANK%E7%BB%86%E8%83%9E%E5%A6%82%E4%BD%95%E4%BD%9C%E7%94%A8%E4%BA%8E%E9%9D%B6%E7%BB%86%E8%83%9E%EF%BC%9F\"><\/span><em><strong><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u95ee\uff1aNK\u7ec6\u80de\u5982\u4f55\u4f5c\u7528\u4e8e\u9776\u7ec6\u80de\uff1f<\/span><\/span><\/span><\/strong><\/em><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: 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