{"id":20710,"date":"2025-12-01T16:44:29","date_gmt":"2025-12-01T08:44:29","guid":{"rendered":"https:\/\/www.hjtdsm.cn\/?p=20710"},"modified":"2025-12-01T16:45:18","modified_gmt":"2025-12-01T08:45:18","slug":"%e5%b0%bd%e7%ae%a1%e9%97%b4%e5%85%85%e8%b4%a8%e5%b9%b2%e7%bb%86%e8%83%9e%ef%bc%88mscs%ef%bc%89%e5%b7%b2%e5%9c%a8%e4%b8%b4%e5%ba%8a%e8%af%95%e9%aa%8c%e4%b8%ad%e7%94%a8%e4%ba%8e%e6%b2%bb%e7%96%97","status":"publish","type":"post","link":"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/mscs\/20710.html","title":{"rendered":"\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6cbb\u7597\u809d\u7ea4\u7ef4\u5316\/\u809d\u786c\u5316\u4e2d\u7684\u4f5c\u7528\uff1a\u4ece\u53d1\u75c5\u673a\u5236\u5230\u4e34\u5e8a\u5e94\u7528"},"content":{"rendered":"<blockquote>\n<p class=\"ds-markdown-paragraph\">\u809d\u810f\u75be\u75c5\u662f\u5168\u7403\u5065\u5eb7\u7684\u91cd\u5927\u5a01\u80c1\uff0c\u6bcf\u5e74\u5bfc\u81f4\u7ea6200\u4e07\u4eba\u6b7b\u4ea1\uff0c\u5176\u4e2d\u809d\u786c\u5316\u5360\u809d\u75c5\u76f8\u5173\u6b7b\u4ea1\u768450%\u3002\u809d\u786c\u5316\u662f\u809d\u7ea4\u7ef4\u5316\u7684\u7ec8\u672b\u9636\u6bb5\uff0c\u7531\u75c5\u6bd2\u6027\u809d\u708e\u3001\u9152\u7cbe\u7b49\u56e0\u7d20\u9020\u6210\u7684\u6162\u6027\u809d\u635f\u4f24\u5f15\u53d1\uff0c\u5176\u7279\u5f81\u662f\u6301\u7eed\u7684\u708e\u75c7\u53cd\u5e94\u5bfc\u81f4\u809d\u661f\u72b6\u7ec6\u80de\u6d3b\u5316\uff0c\u8fdb\u800c\u8fc7\u5ea6\u4ea7\u751f\u80f6\u539f\u86cb\u767d\u548c\u7ec6\u80de\u5916\u57fa\u8d28\uff0c\u6700\u7ec8\u7834\u574f\u809d\u810f\u7684\u6b63\u5e38\u7ed3\u6784\u4e0e\u529f\u80fd\u3002<\/p>\n<\/blockquote>\n<p class=\"ds-markdown-paragraph\"><a href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/mscs\/20023.html\/\" target=\"_blank\" rel=\"noopener\">mesenchymal stem cell MSC (in cell biology)<\/a>\u662f\u4e00\u7c7b\u5177\u6709\u591a\u5411\u5206\u5316\u6f5c\u80fd\u548c\u5f3a\u5927\u81ea\u6211\u66f4\u65b0\u80fd\u529b\u7684\u6210\u4f53\u5e72\u7ec6\u80de\uff0c\u6700\u521d\u4ece\u9aa8\u9ad3\u4e2d\u53d1\u73b0\uff0c\u968f\u540e\u5728\u8102\u80aa\u3001\u8110\u5e26\u7b49\u591a\u79cd\u7ec4\u7ec7\u4e2d\u5747\u6709\u5206\u79bb\u3002\u5b83\u4eec\u5177\u6709\u4f4e\u514d\u75ab\u539f\u6027\uff08\u4e0d\u8868\u8fbeMHC II\u7c7b\u5206\u5b50\uff09\u3001\u6613\u4e8e\u4f53\u5916\u6269\u589e\uff0c\u5e76\u80fd\u5206\u5316\u4e3a\u9aa8\u3001\u8f6f\u9aa8\u3001\u8102\u80aa\u7b49\u591a\u79cd\u7ec6\u80de\u7c7b\u578b\uff0c\u8fd9\u4e9b\u7279\u6027\u4f7f\u5176\u6210\u4e3a\u7ec6\u80de\u6cbb\u7597\u4e0e\u518d\u751f\u533b\u5b66\u4e2d\u6781\u5177\u6f5c\u529b\u7684\u79cd\u5b50\u7ec6\u80de\u3002<\/p>\n<p class=\"ds-markdown-paragraph\">\u9274\u4e8e\u809d\u79fb\u690d\u9762\u4e34\u4f9b\u4f53\u77ed\u7f3a\u548c\u9ad8\u6602\u8d39\u7528\u7b49\u9650\u5236\uff0c<a href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/20701.html\/\" target=\"_blank\" rel=\"noopener\">\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u4e3a\u809d\u786c\u5316\u63d0\u4f9b\u4e86\u4e00\u79cd\u65b0\u7684\u6cbb\u7597\u9009\u62e9<\/a>\u3002\u5176\u4f18\u52bf\u5305\u62ec\u6613\u4e8e\u83b7\u53d6\u4e0e\u6269\u589e\u3001\u53ef\u8fdb\u884c\u5f02\u4f53\u79fb\u690d\u3001\u80fd\u5f52\u5de2\u81f3\u635f\u4f24\u90e8\u4f4d\uff0c\u5e76\u5177\u6709\u6297\u7ea4\u7ef4\u5316\u3001\u514d\u75ab\u8c03\u8282\u53ca\u4fc3\u8fdb\u7ec4\u7ec7\u4fee\u590d\u7684\u529f\u80fd\u3002\u5c3d\u7ba1\u4e34\u5e8a\u524d\u4e0e\u4e34\u5e8a\u7814\u7a76\u5df2\u5c55\u793a\u5176\u826f\u597d\u524d\u666f\uff0c\u4f46\u4ecd\u5b58\u5728\u7597\u6548\u6807\u51c6\u5316\u3001\u4f5c\u7528\u673a\u5236\u4f18\u5316\u7b49\u6311\u6218\uff0c\u672a\u6765\u9700\u8fdb\u4e00\u6b65\u63a2\u7d22\u4ee5\u63d0\u9ad8\u5176\u4e34\u5e8a\u5e94\u7528\u7684\u53ef\u9760\u6027\u4e0e\u6709\u6548\u6027\u3002<\/p>\n<p><img loading=\"lazy\" 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class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/mscs\/20710.html\/#%E6%9D%A5%E6%BA%90\" >\u6765\u6e90<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/mscs\/20710.html\/#%E7%BB%86%E8%83%9E%E5%88%B6%E5%A4%87\" >\u7ec6\u80de\u5236\u5907<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/mscs\/20710.html\/#%E7%A7%BB%E6%A4%8D%E9%80%94%E5%BE%84\" >\u79fb\u690d\u9014\u5f84<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/mscs\/20710.html\/#%E5%89%82%E9%87%8F\" >\u5242\u91cf<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/mscs\/20710.html\/#%E6%82%A3%E8%80%85%E7%97%85%E6%83%85\" >\u60a3\u8005\u75c5\u60c5<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/mscs\/20710.html\/#%E7%BB%93%E8%AE%BA\" >reach a verdict<\/a><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"%E9%97%B4%E5%85%85%E8%B4%A8%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E8%82%9D%E7%BA%A4%E7%BB%B4%E5%8C%96%E8%82%9D%E7%A1%AC%E5%8C%96%E4%B8%AD%E7%9A%84%E4%BD%9C%E7%94%A8%EF%BC%9A%E4%BB%8E%E5%8F%91%E7%97%85%E6%9C%BA%E5%88%B6%E5%88%B0%E4%B8%B4%E5%BA%8A%E6%B2%BB%E7%96%97\"><\/span>\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6cbb\u7597\u809d\u7ea4\u7ef4\u5316\/\u809d\u786c\u5316\u4e2d\u7684\u4f5c\u7528\uff1a\u4ece\u53d1\u75c5\u673a\u5236\u5230\u4e34\u5e8a\u6cbb\u7597<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span dir=\"auto\">\u5916\u6e90\u6027\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09\u5df2\u88ab\u8bc1\u5b9e\u5177\u6709\u6297\u7ea4\u7ef4\u5316\u4f5c\u7528\uff0c\u5176\u4f5c\u7528\u673a\u5236\u4e5f\u591a\u79cd\u591a\u6837\u3002\u7531\u4e8e\u809d\u79fb\u690d\u662f\u76ee\u524d\u6cbb\u7597\u809d\u786c\u5316\u7684\u6709\u6548\u4f20\u7edf\u65b9\u6cd5\uff0c\u800c\u809d\u79fb\u690d\u8d39\u7528\u6602\u8d35\u4e14\u5bfb\u627e\u5408\u9002\u4f9b\u4f53\u8017\u65f6\u8f83\u957f\uff0c\u56e0\u6b64MSCs\u4e3a\u809d\u786c\u5316\u60a3\u8005\u63d0\u4f9b\u4e86\u4e00\u79cd\u65b0\u7684\u6cbb\u7597\u9009\u62e9\u3002MSCs\u56e0\u5176\u4ee5\u4e0b\u7279\u6027\u88ab\u8ba4\u4e3a\u662f\u7ec6\u80de\u6cbb\u7597\u4e2d\u6700\u6709\u524d\u666f\u7684\u7ec6\u80de\uff1a<\/span><\/p>\n<ul>\n<li><span dir=\"auto\">\uff081\uff09\u6613\u4e8e\u4ece\u5404\u79cd\u7ec4\u7ec7\u4e2d\u83b7\u53d6\uff0c\u4e14\u6613\u4e8e\u5728\u4f53\u5916\u6269\u589e\u800c\u4e0d\u6539\u53d8\u5176\u7279\u6027<\/span><span dir=\"auto\">\uff1b<\/span><\/li>\n<li><span dir=\"auto\">\uff082\uff09\u7531\u4e8e\u5176\u514d\u75ab\u539f\u6027\u4f4e\u4e14\u4e0d\u5b58\u5728\u4f26\u7406\u95ee\u9898\uff0c\u56e0\u6b64\u53ef\u4ee5\u8fdb\u884c\u540c\u79cd\u5f02\u4f53\u79fb\u690d<\/span><span dir=\"auto\">\uff1b<\/span><\/li>\n<li><span dir=\"auto\">\uff083\uff09\u80fd\u591f\u8fc1\u79fb\u81f3\u635f\u4f24\u90e8\u4f4d<\/span><span dir=\"auto\">\uff1b<\/span><\/li>\n<li><span dir=\"auto\">\uff084\uff09\u5177\u6709\u591a\u5411\u5206\u5316\u6f5c\u80fd\uff0c\u5e76\u5177\u6709\u826f\u597d\u7684\u518d\u751f\u548c\u635f\u4f24\u4fee\u590d\u4f5c\u7528<\/span><span dir=\"auto\">\uff1b<\/span><\/li>\n<li><span dir=\"auto\">\uff085\uff09\u5177\u6709\u5f3a\u5927\u7684\u514d\u75ab\u8c03\u8282\u80fd\u529b<\/span><span dir=\"auto\">The<\/span><\/li>\n<\/ul>\n<p><span dir=\"auto\">\u6b64\u5916\uff0c\u4e00\u4e9b\u57fa\u7840\u7814\u7a76\u4e5f\u81f4\u529b\u4e8e\u63a2\u7d22\u63d0\u9ad8MSCs\u6cbb\u7597\u809d\u786c\u5316\u7597\u6548\u7684\u65b0\u7b56\u7565\u3002\u5c3d\u7ba1\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09\u5df2\u5728\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u7528\u4e8e\u6cbb\u7597\u809d\u786c\u5316\uff0c\u4e14\u5927\u591a\u6570\u75c5\u4f8b\u53d6\u5f97\u4e86\u826f\u597d\u7684\u7597\u6548\uff0c\u4f46\u8981\u4fc3\u8fdbMSCs\u5728\u672a\u6765\u7684\u4e34\u5e8a\u5e94\u7528\u4e2d\uff0c\u4ecd\u6709\u8bb8\u591a\u95ee\u9898\u9700\u8981\u89e3\u51b3\u3002<a href=\"https:\/\/www.nature.com\/articles\/s41423-023-00983-5\" target=\"_blank\" rel=\"noopener nofollow\">\u672c\u6587\u65e8\u5728\u63a2\u8ba8MSCs\u5728\u809d\u7ea4\u7ef4\u5316\/\u809d\u786c\u5316\u53d1\u75c5\u673a\u5236\u548c\u6cbb\u7597\u4e2d\u7684\u4e0d\u540c\u4f5c\u7528<\/a>\uff0c\u63d0\u51fa\u9700\u8981\u6807\u51c6\u5316\u6216\u4f18\u5316\u7684\u53c2\u6570\uff0c\u5e76\u5c55\u671b\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6cbb\u7597\u809d\u7ea4\u7ef4\u5316\/\u809d\u786c\u5316\u4e2d\u7684\u5e94\u7528\u524d\u666f\u3002<\/span><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-20711 aligncenter\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-01_162407_253.png\" alt=\"\" width=\"758\" height=\"313\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-01_162407_253.png 758w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-01_162407_253-300x124.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-01_162407_253-18x7.png 18w\" sizes=\"(max-width: 758px) 100vw, 758px\" \/><\/p>\n<h2 id=\"Sec2\" class=\"c-article-section__title js-section-title js-c-reading-companion-sections-item\"><span class=\"ez-toc-section\" id=\"%E5%86%85%E6%BA%90%E6%80%A7%E9%97%B4%E5%85%85%E8%B4%A8%E5%B9%B2%E7%BB%86%E8%83%9E%E5%9C%A8%E8%82%9D%E7%BA%A4%E7%BB%B4%E5%8C%96%E5%8F%91%E7%97%85%E6%9C%BA%E5%88%B6%E4%B8%AD%E7%9A%84%E4%BD%9C%E7%94%A8\"><\/span><span dir=\"auto\">\u5185\u6e90\u6027\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u5728\u809d\u7ea4\u7ef4\u5316\u53d1\u75c5\u673a\u5236\u4e2d\u7684\u4f5c\u7528<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<h3><span class=\"ez-toc-section\" id=\"%E9%97%B4%E5%85%85%E8%B4%A8%E5%B9%B2%E7%BB%86%E8%83%9E%E5%AF%B9%E8%82%8C%E6%88%90%E7%BA%A4%E7%BB%B4%E7%BB%86%E8%83%9E%E6%95%B0%E9%87%8F%E5%8F%8A%E8%B0%83%E6%8E%A7%E7%9A%84%E4%BD%9C%E7%94%A8\"><\/span>\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u5bf9\u808c\u6210\u7ea4\u7ef4\u7ec6\u80de\u6570\u91cf\u53ca\u8c03\u63a7\u7684\u4f5c\u7528<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p class=\"ds-markdown-paragraph\"><strong>1. \u808c\u6210\u7ea4\u7ef4\u7ec6\u80de\uff1a\u7ea4\u7ef4\u5316\u7684\u6838\u5fc3\u6548\u5e94\u7ec6\u80de<\/strong><\/p>\n<p class=\"ds-markdown-paragraph\">\u808c\u6210\u7ea4\u7ef4\u7ec6\u80de\u662f\u9a71\u52a8\u7ec4\u7ec7\u7ea4\u7ef4\u5316\u7684\u6838\u5fc3\u7ec6\u80de\uff0c\u5176\u7279\u5f81\u662f\u8868\u8fbe\u03b1-\u5e73\u6ed1\u808c\u808c\u52a8\u86cb\u767d\u5e76\u5177\u6709\u5f3a\u5927\u7684\u6536\u7f29\u80fd\u529b\u53ca\u7ec6\u80de\u5916\u57fa\u8d28\u5408\u6210\u529f\u80fd\u3002\u5728\u6162\u6027\u809d\u635f\u4f24\u4e2d\uff0c\u5176\u6301\u7eed\u6d3b\u5316\u4e0e\u589e\u6b96\u662f\u5bfc\u81f4\u7ec6\u80de\u5916\u57fa\u8d28\u8fc7\u5ea6\u6c89\u79ef\u3001\u6700\u7ec8\u5f62\u6210\u809d\u7ea4\u7ef4\u5316\u4e0e\u809d\u786c\u5316\u7684\u76f4\u63a5\u539f\u56e0\u3002\u56e0\u6b64\uff0c\u9610\u660e\u5176\u7ec6\u80de\u6765\u6e90\u4e0e\u8c03\u63a7\u673a\u5236\u662f\u5f00\u53d1\u6297\u7ea4\u7ef4\u5316\u7597\u6cd5\u7684\u5173\u952e\u3002<\/p>\n<p class=\"ds-markdown-paragraph\"><strong>2. \u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u662f\u808c\u6210\u7ea4\u7ef4\u7ec6\u80de\u7684\u91cd\u8981\u6765\u6e90<\/strong><\/p>\n<p class=\"ds-markdown-paragraph\">\u7814\u7a76\u8868\u660e\uff0c\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u662f\u808c\u6210\u7ea4\u7ef4\u7ec6\u80de\u7684\u91cd\u8981\u7ec6\u80de\u6765\u6e90\u4e4b\u4e00\u3002\u5728\u8f6c\u5316\u751f\u957f\u56e0\u5b50-\u03b2\u7b49\u4fc3\u7ea4\u7ef4\u5316\u56e0\u5b50\u4f5c\u7528\u4e0b\uff0c\u4e0d\u4ec5\u5916\u6e90\u6027\u5f52\u5de2\u81f3\u809d\u810f\u7684\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08\u5982\u9aa8\u9ad3\u6765\u6e90\uff09\u53ef\u5206\u5316\u4e3a\u03b1-\u5e73\u6ed1\u808c\u808c\u52a8\u86cb\u767d\u9633\u6027\u7684\u808c\u6210\u7ea4\u7ef4\u7ec6\u80de\uff0c\u809d\u810f\u5185\u56fa\u6709\u7684\u7ec4\u7ec7\u9a7b\u7559\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08\u5982Gli1\u207a\u7ec6\u80de\uff09\u4e5f\u80fd\u88ab\u6fc0\u6d3b\u5e76\u8f6c\u5316\u4e3a\u808c\u6210\u7ea4\u7ef4\u7ec6\u80de\uff0c\u76f4\u63a5\u8d21\u732e\u4e8e\u7ea4\u7ef4\u5316\u75c5\u7076\u7684\u5f62\u6210\u3002<\/p>\n<p class=\"ds-markdown-paragraph\"><strong>3. \u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u5bf9\u809d\u661f\u72b6\u7ec6\u80de\u6d3b\u5316\u7684\u53cc\u5411\u8c03\u63a7<\/strong><\/p>\n<p class=\"ds-markdown-paragraph\">\u5c3d\u7ba1\u809d\u661f\u72b6\u7ec6\u80de\u88ab\u8ba4\u4e3a\u662f\u809d\u810f\u808c\u6210\u7ea4\u7ef4\u7ec6\u80de\u7684\u4e3b\u8981\u6765\u6e90\uff0c\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u5bf9\u5176\u6d3b\u5316\u8fc7\u7a0b\u5177\u6709\u590d\u6742\u7684\u53cc\u5411\u8c03\u63a7\u4f5c\u7528\u3002\u4e00\u65b9\u9762\uff0c\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u53ef\u80fd\u901a\u8fc7\u5206\u6ccc\u8f6c\u5316\u751f\u957f\u56e0\u5b50-\u03b2\u7b49\u56e0\u5b50\u4fc3\u8fdb\u809d\u661f\u72b6\u7ec6\u80de\u5411\u808c\u6210\u7ea4\u7ef4\u7ec6\u80de\u5206\u5316\uff1b\u53e6\u4e00\u65b9\u9762\uff0c\u66f4\u591a\u8bc1\u636e\u8868\u660e\uff0c\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u53ef\u901a\u8fc7\u7ec6\u80de\u95f4\u63a5\u89e6\uff08\u5982Notch1\u4fe1\u53f7\uff09\u6216\u65c1\u5206\u6ccc\u809d\u7ec6\u80de\u751f\u957f\u56e0\u5b50\u3001\u795e\u7ecf\u751f\u957f\u56e0\u5b50\u7b49\u65b9\u5f0f\uff0c\u6291\u5236\u809d\u661f\u72b6\u7ec6\u80de\u7684\u589e\u6b96\u3001\u6d3b\u5316\u5e76\u8bf1\u5bfc\u5176\u51cb\u4ea1\uff0c\u4ece\u800c\u53d1\u6325\u6297\u7ea4\u7ef4\u5316\u4f5c\u7528\u3002\u8fd9\u79cd\u8c03\u63a7\u7f51\u7edc\u7684\u5177\u4f53\u5e73\u8861\u51b3\u5b9a\u4e86\u7ea4\u7ef4\u5316\u7684\u8fdb\u5c55\u6216\u6d88\u9000\u3002<\/p>\n<h3><span class=\"ez-toc-section\" id=\"%E9%97%B4%E5%85%85%E8%B4%A8%E5%B9%B2%E7%BB%86%E8%83%9E%E5%9C%A8%E8%82%9D%E7%BA%A4%E7%BB%B4%E5%8C%96%E4%B8%AD%E7%9A%84%E5%85%8D%E7%96%AB%E8%B0%83%E8%8A%82%E4%BD%9C%E7%94%A8\"><\/span>\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u5728\u809d\u7ea4\u7ef4\u5316\u4e2d\u7684\u514d\u75ab\u8c03\u8282\u4f5c\u7528<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p class=\"ds-markdown-paragraph\"><strong>\u6025\u6027\u635f\u4f24\u671f\uff1a\u708e\u75c7\u7684\u542f\u52a8\u4e0e\u65e9\u671f\u8c03\u63a7<\/strong><\/p>\n<p class=\"ds-markdown-paragraph\">\u5728\u809d\u7ea4\u7ef4\u5316\u8d77\u59cb\u7684\u6025\u6027\u635f\u4f24\u671f\uff0c\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u626e\u6f14\u4e86\u708e\u75c7\u201c\u542f\u52a8\u54e8\u5175\u201d\u7684\u89d2\u8272\u3002\u5b83\u80fd\u611f\u77e5\u53d7\u635f\u809d\u7ec6\u80de\u91ca\u653e\u7684\u4f4e\u6d53\u5ea6\u5371\u9669\u4fe1\u53f7\uff0c\u5e76\u5206\u6ccc\u8d8b\u5316\u56e0\u5b50\uff08\u5982CCL2\uff09\uff0c\u4e3b\u52a8\u52df\u96c6\u5355\u6838\u7ec6\u80de\u3001\u4e2d\u6027\u7c92\u7ec6\u80de\u7b49\u56fa\u6709\u514d\u75ab\u7ec6\u80de\u81f3\u635f\u4f24\u90e8\u4f4d\uff0c\u4ece\u800c\u542f\u52a8\u708e\u75c7\u53cd\u5e94\u3002\u540c\u65f6\uff0c\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u901a\u8fc7\u7ec4\u6210\u6027\u5206\u6cccIL-6\u7b49\u56e0\u5b50\uff0c\u5ef6\u957f\u4e2d\u6027\u7c92\u7ec6\u80de\u7684\u5b58\u6d3b\u65f6\u95f4\uff0c\u4e3a\u5176\u6e05\u9664\u574f\u6b7b\u7ec6\u80de\u3001\u5b8c\u6210\u65e9\u671f\u4fee\u590d\u4efb\u52a1\u63d0\u4f9b\u7a97\u53e3\uff0c\u4f53\u73b0\u4e86\u5176\u5728\u708e\u75c7\u521d\u59cb\u9636\u6bb5\u7684\u7cbe\u7ec6\u8c03\u63a7\u3002<\/p>\n<p class=\"ds-markdown-paragraph\"><strong>\u708e\u75c7\u6d88\u9000\u671f\uff1a\u5851\u9020\u6297\u708e\u5fae\u73af\u5883\u7684\u6838\u5fc3\u8c03\u8282\u8005<\/strong><\/p>\n<p 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class=\"ds-markdown-paragraph\"><strong>\u9776\u5411\u6291\u5236\u809d\u661f\u72b6\u7ec6\u80de\u6d3b\u5316\uff1a\u6297\u7ea4\u7ef4\u5316\u7684\u6838\u5fc3\u8def\u5f84<\/strong><\/p>\n<p class=\"ds-markdown-paragraph\">\u6291\u5236\u809d\u661f\u72b6\u7ec6\u80de\u7684\u6d3b\u5316\u662f\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u53d1\u6325\u6297\u7ea4\u7ef4\u5316\u4f5c\u7528\u7684\u6838\u5fc3\u673a\u5236\u4e4b\u4e00\u3002\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u901a\u8fc7\u76f4\u63a5\u63a5\u89e6\u6216\u65c1\u5206\u6ccc\u591a\u79cd\u56e0\u5b50\uff08\u5982\u809d\u7ec6\u80de\u751f\u957f\u56e0\u5b50\u3001\u795e\u7ecf\u751f\u957f\u56e0\u5b50\u3001\u5916\u6ccc\u4f53\u643a\u5e26\u7684circDIDO1\uff09\uff0c\u8c03\u63a7\u5173\u952e\u4fe1\u53f7\u901a\u8def\uff08\u5982Notch\u3001PI3K\/AKT\u3001ERK1\/2\u3001TGF-\u03b2\/Smad\uff09\uff0c\u4ece\u800c\u6709\u6548\u6291\u5236\u809d\u661f\u72b6\u7ec6\u80de\u7684\u589e\u6b96\u3001\u4fc3\u8fdb\u5176\u51cb\u4ea1\u5e76\u5c06\u5176\u963b\u6ede\u4e8e\u7ec6\u80de\u5468\u671f\u9759\u6b62\u671f\u3002\u540c\u65f6\uff0c\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u8fd8\u80fd\u5206\u6ccc\u57fa\u8d28\u91d1\u5c5e\u86cb\u767d\u9176\u53ca\u5176\u6291\u5236\u5242\uff0c\u5e76\u53ef\u80fd\u901a\u8fc7\u7ec6\u80de\u5916\u56ca\u6ce1\u5f71\u54cd\u808c\u6210\u7ea4\u7ef4\u7ec6\u80de\uff0c\u4ece\u800c\u53c2\u4e0e\u964d\u89e3\u8fc7\u5ea6\u6c89\u79ef\u7684\u7ec6\u80de\u5916\u57fa\u8d28\uff0c\u4ece\u591a\u4e2a\u73af\u8282\u9006\u8f6c\u7ea4\u7ef4\u5316\u8fdb\u7a0b\u3002<\/p>\n<p class=\"ds-markdown-paragraph\"><strong>\u8c03\u63a7\u708e\u75c7\u5fae\u73af\u5883\uff1a\u521b\u9020\u4fee\u590d\u6761\u4ef6<\/strong><\/p>\n<p class=\"ds-markdown-paragraph\">\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u901a\u8fc7\u5851\u9020\u4e00\u4e2a\u6709\u5229\u4e8e\u4fee\u590d\u7684\u514d\u75ab\u5fae\u73af\u5883\uff0c\u95f4\u63a5\u4fdd\u62a4\u809d\u7ec6\u80de\u5e76\u6291\u5236\u7ea4\u7ef4\u5316\u3002\u5176\u7ec4\u6210\u6027\u6216\u8bf1\u5bfc\u6027\u4ea7\u751f\u7684\u514d\u75ab\u8c03\u8282\u5206\u5b50\uff08\u5982\u4e00\u6c27\u5316\u6c2e\u3001\u524d\u5217\u817a\u7d20E2\u3001\u5432\u54da\u80fa2,3-\u53cc\u52a0\u6c27\u9176\u3001\u767d\u7ec6\u80de\u4ecb\u7d20-6\u7b49\uff09\uff0c\u80fd\u591f\u5e7f\u6cdb\u8c03\u63a7\u5404\u7c7b\u514d\u75ab\u7ec6\u80de\u529f\u80fd\u3002\u4f8b\u5982\uff0c\u6291\u5236T\u7ec6\u80de\u3001\u81ea\u7136\u6740\u4f24\u7ec6\u80de\u7684\u8fc7\u5ea6\u6d3b\u5316\uff0c\u4fc3\u8fdb\u8c03\u8282\u6027T\u7ec6\u80de\u7684\u751f\u6210\uff0c\u5e76\u5f15\u5bfc\u5de8\u566c\u7ec6\u80de\u5411\u6297\u708e\u7684M2\u8868\u578b\u6781\u5316\u3002\u8fd9\u79cd\u591a\u9776\u70b9\u7684\u514d\u75ab\u8c03\u8282\u4f5c\u7528\uff0c\u6709\u6548\u51cf\u8f7b\u4e86\u9a71\u52a8\u809d\u7ec6\u80de\u6301\u7eed\u635f\u4f24\u548c\u661f\u72b6\u7ec6\u80de\u6d3b\u5316\u7684\u708e\u75c7\u53cd\u5e94\uff0c\u4e3a\u809d\u810f\u7684\u5b9e\u8d28\u6027\u4fee\u590d\u521b\u9020\u4e86\u5fc5\u8981\u7684\u5c40\u90e8\u6761\u4ef6\u3002<\/p>\n<h2 id=\"Sec23\" class=\"c-article-section__title js-section-title js-c-reading-companion-sections-item\"><span class=\"ez-toc-section\" id=\"%E9%97%B4%E5%85%85%E8%B4%A8%E5%B9%B2%E7%BB%86%E8%83%9E%E5%9C%A8%E8%82%9D%E7%A1%AC%E5%8C%96%E6%B2%BB%E7%96%97%E4%B8%AD%E7%9A%84%E4%B8%B4%E5%BA%8A%E5%BA%94%E7%94%A8\"><\/span><span dir=\"auto\">\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u5728\u809d\u786c\u5316\u6cbb\u7597\u4e2d\u7684\u4e34\u5e8a\u5e94\u7528<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<div id=\"Sec23-content\" class=\"c-article-section__content\">\n<h3 id=\"Sec24\" class=\"c-article__sub-heading\"><span class=\"ez-toc-section\" id=\"%E4%B8%B4%E5%BA%8A%E8%AF%95%E9%AA%8C%E4%B8%AD%E9%97%B4%E5%85%85%E8%B4%A8%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E8%82%9D%E7%A1%AC%E5%8C%96%E7%9A%84%E6%A6%82%E8%BF%B0\"><\/span><span dir=\"auto\">\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6cbb\u7597\u809d\u786c\u5316\u7684\u6982\u8ff0<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span dir=\"auto\">\u57fa\u4e8e\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09\u7684\u8bf8\u591a\u7279\u6027\uff0c\u5305\u62ec\u6613\u4e8e\u4f53\u5916\u5206\u79bb\u548c\u6269\u589e\u3001\u81ea\u6211\u66f4\u65b0\u548c\u591a\u5411\u5206\u5316\u80fd\u529b\u3001\u635f\u4f24\u8d8b\u5411\u6027\u3001\u514d\u75ab\u8c03\u8282\u4ee5\u53ca\u4f4e\u514d\u75ab\u539f\u6027\uff0c\u8fd9\u4e9b\u7ec6\u80de\u88ab\u8ba4\u4e3a\u662f\u7ec6\u80de\u6cbb\u7597\u4e2d\u6700\u6709\u524d\u666f\u7684\u5019\u9009\u8005\u3002MSCs\u5df2\u88ab\u7528\u4e8e\u6cbb\u7597\u591a\u79cd\u4e0e\u708e\u75c7\u548c\u635f\u4f24\u76f8\u5173\u7684\u75be\u75c5<\/span><span dir=\"auto\">\u3002\u809d\u810f\u75be\u75c5\u4e0e\u514d\u75ab\u53cd\u5e94\u548c\u7ec4\u7ec7\u635f\u4f24\u5bc6\u5207\u76f8\u5173\u3002\u56e0\u6b64\uff0c\u809d\u810f\u75be\u75c5\u662fMSCs\u6cbb\u7597\u7684\u7406\u60f3\u9776\u70b9\u3002\u622a\u81f32022\u5e7410\u6708\uff0c\u5728<\/span><a href=\"https:\/\/clinicaltrials.gov\/\" rel=\"nofollow noopener\" target=\"_blank\"><span dir=\"auto\">https:\/\/clinicaltrials.gov\/\u7f51\u7ad9<\/span><\/a><span dir=\"auto\">\u4e0a\u6ce8\u518c\u7684\u6d89\u53caMSCs\u5e72\u9884\u7684\u75be\u75c5\u4e34\u5e8a\u8bd5\u9a8c\u5171\u670968\u9879\uff0c\u5176\u4e2d\u5927\u591a\u6570\u96c6\u4e2d\u4e8e\u809d\u786c\u5316\uff08<\/span><i><span dir=\"auto\">n<\/span><\/i><span dir=\"auto\"> =47\uff09\uff08\u56fe<\/span><span dir=\"auto\">2A<\/span><span dir=\"auto\">\uff09\u3002<\/span><\/p>\n<div id=\"attachment_20714\" style=\"width: 1979px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-20714\" class=\"wp-image-20714 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/\u5fae\u4fe1\u56fe\u7247_2025-12-01_162618_932.png\" alt=\"\" width=\"1969\" height=\"351\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/\u5fae\u4fe1\u56fe\u7247_2025-12-01_162618_932.png 1969w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/\u5fae\u4fe1\u56fe\u7247_2025-12-01_162618_932-300x53.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/\u5fae\u4fe1\u56fe\u7247_2025-12-01_162618_932-1024x183.png 1024w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/\u5fae\u4fe1\u56fe\u7247_2025-12-01_162618_932-768x137.png 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/\u5fae\u4fe1\u56fe\u7247_2025-12-01_162618_932-1536x274.png 1536w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/\u5fae\u4fe1\u56fe\u7247_2025-12-01_162618_932-18x3.png 18w\" sizes=\"(max-width: 1969px) 100vw, 1969px\" \/><p id=\"caption-attachment-20714\" class=\"wp-caption-text\">\u56fe2\uff1a\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09\u6cbb\u7597\u809d\u75c5\u7684\u4e34\u5e8a\u8bd5\u9a8c\u3002A\uff0c\u57fa\u4e8eMSCs\u7684\u809d\u75c5\u4e34\u5e8a\u8bd5\u9a8c\u603b\u4f53\u60c5\u51b5\uff08\u6309\u809d\u75c5\u7c7b\u578b\u5206\u7c7b\uff09\u3002B\uff0c\u57fa\u4e8eMSCs\u7684\u809d\u786c\u5316\u4e34\u5e8a\u8bd5\u9a8c\uff08\u6309\u4e34\u5e8a\u9636\u6bb5\u5206\u7c7b\uff09\u3002C\uff0c\u57fa\u4e8eMSCs\u7684\u809d\u786c\u5316\u4e34\u5e8a\u8bd5\u9a8c\uff08\u6309\u4e34\u5e8a\u72b6\u6001\u5206\u7c7b\uff09\u3002\u6570\u636e\u4ee5\u6570\u91cf\u548c\u767e\u5206\u6bd4\u8868\u793a\u3002<\/p><\/div>\n<p><span dir=\"auto\">\u5df2\u670910\u9879\u8bd5\u9a8c\u5b8c\u6210\uff0c\u4f46\u4ec5\u67096\u9879\u516c\u5e03\u4e86\u7ed3\u679c\u3002\u56e0\u6b64\uff0c\u76ee\u524d\u53ef\u7528\u4e8e\u8bc4\u4f30MSCs\u6cbb\u7597\u6548\u679c\u7684\u6570\u636e\u6709\u9650\u3002\u6211\u4eec\u8fd8\u6536\u96c6\u4e8614\u7bc7\u5df2\u53d1\u8868\u7684\u5173\u4e8eMSCs\u6cbb\u7597\u809d\u786c\u5316\u7684\u4e34\u5e8a\u8bd5\u9a8c\u6587\u7ae0\uff0c\u8fd9\u4e9b\u6587\u7ae0\u4e0e\u5df2\u5b8c\u6210\u5e76\u516c\u5e03\u7ed3\u679c\u76846\u9879\u4e34\u5e8a\u8bd5\u9a8c\u6709\u6240\u91cd\u53e0\u3002\u56e0\u6b64\uff0c\u6211\u4eec\u53c2\u8003\u4e86\u8fd914\u7bc7\u5df2\u53d1\u8868\u7684\u6587\u7ae0\u6765\u8bc4\u4ef7MSC\u6cbb\u7597\u809d\u786c\u5316\u7684\u6548\u679c\u3002<\/span><\/p>\n<p><span dir=\"auto\">\u5728\u7eb3\u5165\u768414\u7bc7\u6587\u7ae0\u4e2d\uff0c\u670912\u7bc7\u901a\u8fc7\u8bc4\u4f30\u809d\u529f\u80fd\u3001\u809d\u810f\u4f53\u79ef\u3001\u7ec8\u672b\u671f\u809d\u75c5\u6a21\u578b\uff08MELD\uff09\u8bc4\u5206\u548c\u7ec6\u80de\u56e0\u5b50\u8868\u8fbe\uff0c\u63ed\u793a\u4e86\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09\u5bf9\u809d\u786c\u5316\u7684\u663e\u8457\u7597\u6548\u3002\u8fd9\u4e9b\u7814\u7a76\u5927\u591a\u5bf9\u60a3\u8005\u8fdb\u884c\u4e86\u8d85\u8fc76\u4e2a\u6708\u7684\u968f\u8bbf\uff0c\u5e76\u9a8c\u8bc1\u4e86MSC\u79fb\u690d\u7684\u5b89\u5168\u6027\u3002<\/span><\/p>\n<p><span dir=\"auto\">\u6211\u4eec\u8ba4\u4e3a\uff0c2021\u5e74\u53d1\u8868\u7684\u4e00\u9879\u5173\u4e8e\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u76f8\u5173\u5931\u4ee3\u507f\u671f\u809d\u786c\u5316\u7684II\u671f\u7814\u7a76<\/span><span dir=\"auto\">\u6700\u5177\u8bf4\u670d\u529b\uff0c\u56e0\u4e3a\u5b83\u5177\u6709\u6700\u957f\u7684\u968f\u8bbf\u65f6\u95f4\u548c\u6700\u5927\u7684\u6837\u672c\u91cf\u3002\u8be5\u7814\u7a76\u7eb3\u5165\u4e86219\u4f8b\u60a3\u8005\uff0c\u5e76\u5c06\u5176\u5206\u4e3a\u5bf9\u7167\u7ec4\uff08<\/span><i><span dir=\"auto\">n<\/span><\/i><span dir=\"auto\"> =111\uff09\u548c\u8110\u5e26\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08UC-MSC\uff09\u6cbb\u7597\u7ec4\uff08<\/span><i><span dir=\"auto\">n<\/span><\/i><span dir=\"auto\">=108\uff09\u3002UC-MSC\u6bcf\u6708\u79fb\u690d\u4e00\u6b21\uff0c\u5171\u79fb\u690d3\u6b21\uff0c\u60a3\u8005\u968f\u8bbf75\u4e2a\u6708\u3002<strong>\u672a\u89c2\u5bdf\u5230\u660e\u663e\u7684\u526f\u4f5c\u7528\uff0cUC-MSC\u6cbb\u7597\u7ec4\u7684\u603b\u751f\u5b58\u7387\u663e\u8457\u63d0\u9ad8\uff0c\u809d\u529f\u80fd\u4e5f\u5f97\u5230\u6539\u5584<\/strong>\u3002\u7136\u800c\uff0c\u5e76\u975e\u6240\u6709\u7814\u7a76\u90fd\u663e\u793a\u51fa\u79ef\u6781\u7684\u7ed3\u679c\u3002\u4e24\u9879\u4e34\u5e8a\u8bd5\u9a8c\u5747\u672a\u89c2\u5bdf\u5230\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u5bf9\u809d\u529f\u80fd\u7684\u4efb\u4f55\u6cbb\u7597\u4f5c\u7528<\/span><span dir=\"auto\">\u3002\u8fd9\u4e24\u9879\u7814\u7a76\u5206\u522b\u7eb3\u5165\u4e8627\u4f8b\u548c12\u4f8b\u60a3\u8005\u3002\u8fd9\u4e00\u7ed3\u679c\u53ef\u80fd\u662f\u7531\u4e8e\u6837\u672c\u91cf\u8f83\u5c0f\uff0c\u4e14\u4e2a\u4f53\u5dee\u5f02\u53ef\u80fd\u5f71\u54cd\u7ed3\u679c\u3002<\/span><\/p>\n<p><span dir=\"auto\">\u5728\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u6709\u4e24\u9879\u7814\u7a76\u4f7f\u7528\u6e90\u81ea\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09\u7684\u809d\u7ec6\u80de\u6cbb\u7597\u809d\u786c\u5316\uff0c\u8fd9\u4e3aMSCs\u5728\u809d\u786c\u5316\u6cbb\u7597\u4e2d\u7684\u5e94\u7528\u63d0\u4f9b\u4e86\u53e6\u4e00\u79cd\u53ef\u80fd\u6027\u3002\u7814\u7a76\u4eba\u5458\u4f7f\u7528\u809d\u7ec6\u80de\u751f\u957f\u56e0\u5b50\uff08HGF\uff09\u3001\u5730\u585e\u7c73\u677e\uff08DEX\uff09\u548c\u6291\u7624\u7d20M\uff08OSM\uff09\u8bf1\u5bfcMSCs\u5206\u5316\u4e3a\u809d\u7ec6\u80de\uff0c\u8bf1\u5bfc\u671f\u7ea6\u4e3a28\u5929\uff0c\u4e4b\u540e\u5c06MSCs\u6ce8\u5c04\u5230\u60a3\u8005\u4f53\u5185[\u00a0<\/span><a id=\"ref-link-section-d249540124e2118\" title=\"Kharaziha P\u3001Hellstr\u00f6m PM\u3001Noorinayer B\u3001Farzaneh F\u3001Aghajani K\u3001Jafari F \u7b49\u3002\u81ea\u4f53\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6ce8\u5c04\u540e\u809d\u786c\u5316\u60a3\u8005\u809d\u529f\u80fd\u7684\u6539\u5584\uff1a\u4e00\u9879 I-II \u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002Eur J Gastroenterol Hepatol. 2009;21:1199\u2013205\u3002\" href=\"https:\/\/www.nature.com\/articles\/s41423-023-00983-5#ref-CR176\" data-track=\"click\" data-track-action=\"reference anchor\" data-track-label=\"link\" data-test=\"citation-ref\" aria-label=\"\u53c2\u8003\u6587\u732e176\" rel=\"nofollow noopener\" target=\"_blank\"><span dir=\"auto\">176<\/span><\/a><span dir=\"auto\">\u00a0]\u3002\u7ecf\u8fc724\u5468\u7684\u968f\u8bbf\uff0c<strong>\u809d\u529f\u80fd\u5f97\u5230\u6539\u5584\uff0cMELD\u8bc4\u5206\u3001\u51dd\u8840\u9176\u539f\u590d\u5408\u7269\u6c34\u5e73\u3001\u8840\u6e05\u808c\u9150\u548c\u80c6\u7ea2\u7d20\u6c34\u5e73\u5747\u6709\u6240\u4e0b\u964d\uff0c\u8840\u6e05\u767d\u86cb\u767d\u6c34\u5e73\u6709\u6240\u5347\u9ad8\uff0c\u4e14\u672a\u89c2\u5bdf\u5230\u4efb\u4f55\u4e0d\u826f\u53cd\u5e94<\/strong>\u3002\u7136\u800c\uff0c\u5728\u7ea62\u4e2a\u6708\u7684\u6cbb\u7597\u671f\u95f4\uff0c\u670910\u540d\u60a3\u8005\u56e0\u75c5\u60c5\u4e25\u91cd\u800c\u6b7b\u4ea1\u3002<\/span><\/p>\n<p><span dir=\"auto\">\u5728\u53e6\u4e00\u9879II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u6bd4\u8f83\u4e86\u672a\u5206\u5316MSCs\u548c\u809d\u7ec6\u80de\u5206\u5316MSCs\u7684\u7597\u6548[\u00a0<\/span><a id=\"ref-link-section-d249540124e2121\" title=\"El-Ansary M\u3001Abdel-Aziz I\u3001Mogawer S\u3001Abdel-Hamid S\u3001Hammam O\u3001Teaema S \u7b49\u3002II \u671f\u8bd5\u9a8c\uff1a\u672a\u5206\u5316\u4e0e\u5206\u5316\u81ea\u4f53\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u79fb\u690d\u6cbb\u7597\u57c3\u53ca HCV \u8bf1\u5bfc\u7684\u809d\u786c\u5316\u60a3\u8005\u7684\u7597\u6548\u6bd4\u8f83\u3002\u5e72\u7ec6\u80de\u8bc4\u8bba\u62a5\u544a\u30022012\uff1b8\uff1a972\u201381\u3002\" href=\"https:\/\/www.nature.com\/articles\/s41423-023-00983-5#ref-CR177\" data-track=\"click\" data-track-action=\"reference anchor\" data-track-label=\"link\" data-test=\"citation-ref\" aria-label=\"\u53c2\u8003\u6587\u732e177\" rel=\"nofollow noopener\" target=\"_blank\"><span dir=\"auto\">177<\/span><\/a><span dir=\"auto\">\u00a0]\u3002\u8f93\u6ce8\u540e3\u4e2a\u6708\u548c6\u4e2a\u6708\u7684\u968f\u8bbf\u663e\u793a\uff0c<strong>\u4e24\u7ec4\u60a3\u8005\u7684\u809d\u529f\u80fd\u6307\u6807\u5747\u6709\u90e8\u5206\u6539\u5584\uff0c\u51dd\u8840\u9176\u539f\u6d53\u5ea6\u548c\u8840\u6e05\u767d\u86cb\u767d\u6c34\u5e73\u5347\u9ad8\uff0c\u80c6\u7ea2\u7d20\u6c34\u5e73\u548cMELD\u8bc4\u5206\u5747\u964d\u4f4e<\/strong>\u3002\u7136\u800c\uff0c\u672a\u5206\u5316\u548c\u5206\u5316MSC\u7ec4\u4e4b\u95f4\u7684\u7edf\u8ba1\u5b66\u6bd4\u8f83\u5e76\u672a\u663e\u793a\u4e34\u5e8a\u548c\u5b9e\u9a8c\u5ba4\u68c0\u67e5\u7ed3\u679c\u5b58\u5728\u663e\u8457\u5dee\u5f02\u3002<\/span><\/p>\n<h2 id=\"Sec25\" class=\"c-article__sub-heading\"><span class=\"ez-toc-section\" id=\"%E9%97%B4%E5%85%85%E8%B4%A8%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E8%82%9D%E7%BA%A4%E7%BB%B4%E5%8C%96%E8%82%9D%E7%A1%AC%E5%8C%96%E7%9A%84%E4%B8%B4%E5%BA%8A%E5%BA%94%E7%94%A8%E4%B8%AD%E9%9C%80%E8%A6%81%E6%A0%87%E5%87%86%E5%8C%96%E7%9A%84%E5%8F%82%E6%95%B0\"><\/span><span dir=\"auto\">\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6cbb\u7597\u809d\u7ea4\u7ef4\u5316\/\u809d\u786c\u5316\u7684\u4e34\u5e8a\u5e94\u7528\u4e2d\u9700\u8981\u6807\u51c6\u5316\u7684\u53c2\u6570<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span dir=\"auto\">\u5728\u8fd9\u4e9b\u809d\u786c\u5316\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u5927\u591a\u6570\uff0857.45%\uff09\u5904\u4e8eII\u671f\uff0c\u4ec5\u6709\u4e00\u9879\u5904\u4e8eIV\u671f\uff08\u56fe<\/span><span dir=\"auto\">2B<\/span><span dir=\"auto\">\uff09\u3002\u4ec5\u670910\u9879\u4e34\u5e8a\u8bd5\u9a8c\u5df2\u5b8c\u6210\uff0821.28%\uff09\u3002\u5927\u591a\u6570\u8bd5\u9a8c\u6b63\u5728\u62db\u52df\u6216\u5c1a\u672a\u62db\u52df\u53d7\u8bd5\u8005\uff08\u56fe<\/span><span dir=\"auto\">2C\uff09\u3002\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09\u4e34\u5e8a\u5e94\u7528\u8fdb\u5c55\u7f13\u6162\u53ef\u80fd\u4e0e\u4e00\u4e9b\u4e0d\u591f\u7cbe\u786e\u7684\u6cbb\u7597\u6807\u51c6\u6709\u5173\u3002\u5982\u56fe3<\/span><span dir=\"auto\">\u6240\u793a\u00a0\uff0c\u4e34\u5e8a\u4e0a\u6d89\u53ca\u7ec6\u80de\u548c\u60a3\u8005\u65b9\u9762\u7684\u8bf8\u591a\u53c2\u6570\uff0c\u5305\u62ecMSCs\u7684\u6765\u6e90\u3001\u7ec6\u80de\u5236\u5907\u65b9\u6cd5\u3001\u5242\u91cf\u3001\u79fb\u690d\u9014\u5f84\u4ee5\u53ca\u60a3\u8005\u72b6\u51b5\u7b49\uff0c\u8fd9\u4e9b\u53c2\u6570\u5fc5\u987b\u6807\u51c6\u5316\u624d\u80fd\u4fc3\u8fdbMSCs\u7684\u4e34\u5e8a\u5e94\u7528\u3002<\/span><\/p>\n<div id=\"attachment_20713\" style=\"width: 1979px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-20713\" class=\"wp-image-20713 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/\u5fae\u4fe1\u56fe\u7247_2025-12-01_162633_554.png\" alt=\"\" width=\"1969\" height=\"663\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/\u5fae\u4fe1\u56fe\u7247_2025-12-01_162633_554.png 1969w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/\u5fae\u4fe1\u56fe\u7247_2025-12-01_162633_554-300x101.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/\u5fae\u4fe1\u56fe\u7247_2025-12-01_162633_554-1024x345.png 1024w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/\u5fae\u4fe1\u56fe\u7247_2025-12-01_162633_554-768x259.png 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/\u5fae\u4fe1\u56fe\u7247_2025-12-01_162633_554-1536x517.png 1536w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/\u5fae\u4fe1\u56fe\u7247_2025-12-01_162633_554-18x6.png 18w\" sizes=\"(max-width: 1969px) 100vw, 1969px\" \/><p id=\"caption-attachment-20713\" class=\"wp-caption-text\">\u56fe3\uff1a\u5728\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09\u6cbb\u7597\u809d\u786c\u5316\u7684\u4e34\u5e8a\u5e94\u7528\u4e2d\uff0c\u5404\u9879\u53c2\u6570\u9700\u8981\u7cbe\u786e\u6807\u51c6\u5316\u3002\u76ee\u524d\uff0c\u7528\u4e8e\u809d\u786c\u5316\u4e34\u5e8a\u8bd5\u9a8c\u7684MSCs\u6765\u6e90\u591a\u6837\uff08\u9aa8\u9ad3\u3001\u8110\u5e26\u3001\u8102\u80aa\u7ec4\u7ec7\u548c\u7ecf\u8840\uff09\u3002MSCs\u5236\u5907\u8fc7\u7a0b\u4e2d\u5b58\u5728\u8bf8\u591a\u4e0d\u7cbe\u786e\u7684\u53c2\u6570\uff0c\u5305\u62ec\u4f9b\u4f53\u9009\u62e9\u3001\u5206\u79bb\u65b9\u6cd5\u3001\u57f9\u517b\u6761\u4ef6\u3001\u51b7\u51bb\u4fdd\u5b58\u548c\u590d\u82cf\u4ee5\u53ca\u7ec6\u80de\u5f02\u8d28\u6027\u7b49\u3002\u6b64\u5916\uff0cMSCs\u7684\u7ed9\u836f\u5242\u91cf\u548c\u7ed9\u836f\u9014\u5f84\u4e5f\u5404\u4e0d\u76f8\u540c\u3002\u4e0a\u8ff0\u6240\u6709\u53c2\u6570\u90fd\u4f1a\u5f71\u54cdMSCs\u7684\u6cbb\u7597\u6548\u679c\uff0c\u56e0\u6b64\uff0c\u5236\u5b9aMSCs\u4e34\u5e8a\u5e94\u7528\u7684\u6700\u4f73\u6807\u51c6\u5bf9\u4e8e\u672a\u6765MSCs\u7684\u6210\u529f\u4e34\u5e8a\u8f6c\u5316\u81f3\u5173\u91cd\u8981\u3002<\/p><\/div>\n<h3 id=\"Sec26\" class=\"c-article__sub-heading c-article__sub-heading--small\"><span class=\"ez-toc-section\" id=\"%E6%9D%A5%E6%BA%90\"><\/span><span dir=\"auto\">\u6765\u6e90<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span dir=\"auto\">\u5c3d\u7ba1\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09\u53ef\u4ee5\u4ece\u591a\u79cd\u7ec4\u7ec7\u4e2d\u5206\u79bb\u51fa\u6765\uff0c\u4f8b\u5982\u8110\u5e26\uff08UC\uff09<\/span><span dir=\"auto\">\u3001\u9aa8\u9ad3\uff08BM\uff09<\/span><span dir=\"auto\">\u3001\u76ae\u4e0b\u8102\u80aa\uff08AD \uff09<\/span><span dir=\"auto\">\u3001\u8110\u5e26\u8840<\/span><span dir=\"auto\">\u3001\u80ce\u76d8<\/span><span dir=\"auto\">\u3001\u7f8a\u6c34<\/span><span dir=\"auto\"> \u3001\u7f8a\u819c<\/span><span dir=\"auto\">\u3001\u7259\u9ad3<\/span><span dir=\"auto\">\u3001\u6ed1\u819c<\/span><span dir=\"auto\">\u3001\u5916\u5468\u8840\u3001\u809d\u810f\u3001\u80ba<\/span><span dir=\"auto\">\u3001\u9aa8\u9abc\u808c<\/span><span dir=\"auto\">\u548c\u6bdb\u56ca<\/span><span dir=\"auto\">\uff0c\u4f46\u4e34\u5e8a\u8bd5\u9a8c\u4e3b\u8981\u91c7\u7528\u7684\u662f\u8110\u5e26\u6765\u6e90\u7684MSCs\uff08UC-MSCs\uff09\u548c\u9aa8\u9ad3\u6765\u6e90\u7684MSCs\uff08BM-MSCs\uff09\uff08\u56fe<\/span><span dir=\"auto\">4A<\/span><span dir=\"auto\">\uff09\u3002\u8fd9\u53ef\u80fd\u662f\u56e0\u4e3a\u8fd9\u4e9b\u7ec6\u80de\u7684\u7814\u7a76\u6700\u4e3a\u6df1\u5165\uff0c\u4e14\u76f8\u5bf9\u5bb9\u6613\u83b7\u53d6\u3002\u9c9c\u6709\u7814\u7a76\u5728\u540c\u4e00\u9879\u7814\u7a76\u4e2d\u63a2\u8ba8\u4e0d\u540c\u6765\u6e90MSCs\u7684\u6cbb\u7597\u6548\u679c\u3002\u9aa8\u9ad3\u6765\u6e90\u7684MSCs\u4e3b\u8981\u9002\u7528\u4e8e\u81ea\u4f53\u79fb\u690d\u3002\u7136\u800c\uff0c\u9aa8\u9ad3\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08BM-MSC\uff09\u79fb\u690d\u4e5f\u5b58\u5728\u4e00\u4e9b\u5c40\u9650\u6027\u3002\u4fb5\u5165\u6027\u5206\u79bb\u8fc7\u7a0b\u4f1a\u5bf9\u4f9b\u4f53\u9020\u6210\u635f\u4f24\u548c\u708e\u75c7\uff0c\u4e14\u5176\u6548\u7387\u4f4e\u4e8e\u5176\u4ed6\u6765\u6e90\u7684\u95f4\u5145\u8d28\u5e72\u7ec6\u80de<\/span><span dir=\"auto\">\u3002BM-MSC\u7684\u6570\u91cf\u548c\u6cbb\u7597\u6548\u679c\u4e5f\u53d7\u4f9b\u4f53\u81ea\u8eab\u72b6\u51b5\u7684\u5f71\u54cd\u3002<\/span><\/p>\n<div id=\"attachment_20712\" style=\"width: 1985px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-20712\" class=\"wp-image-20712 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/\u5fae\u4fe1\u56fe\u7247_2025-12-01_162647_011.png\" alt=\"\" width=\"1975\" height=\"544\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/\u5fae\u4fe1\u56fe\u7247_2025-12-01_162647_011.png 1975w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/\u5fae\u4fe1\u56fe\u7247_2025-12-01_162647_011-300x83.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/\u5fae\u4fe1\u56fe\u7247_2025-12-01_162647_011-1024x282.png 1024w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/\u5fae\u4fe1\u56fe\u7247_2025-12-01_162647_011-768x212.png 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/\u5fae\u4fe1\u56fe\u7247_2025-12-01_162647_011-1536x423.png 1536w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/\u5fae\u4fe1\u56fe\u7247_2025-12-01_162647_011-18x5.png 18w\" sizes=\"(max-width: 1975px) 100vw, 1975px\" \/><p id=\"caption-attachment-20712\" class=\"wp-caption-text\">\u56fe4\uff1a\u57fa\u4e8e\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09\u6cbb\u7597\u809d\u786c\u5316\u7684\u4e34\u5e8a\u8bd5\u9a8c\u3002A \uff0c\u57fa\u4e8e\u4e0d\u540c\u6765\u6e90MSCs\u6cbb\u7597\u809d\u786c\u5316\u7684\u4e34\u5e8a\u8bd5\u9a8c\u3002B \uff0c\u57fa\u4e8e\u81ea\u4f53\u548c\u5f02\u4f53MSCs\u79fb\u690d\u6cbb\u7597\u809d\u786c\u5316\u7684\u4e34\u5e8a\u8bd5\u9a8c\u3002C \uff0c\u57fa\u4e8eMSCs\u79fb\u690d\u9014\u5f84\u6cbb\u7597\u809d\u786c\u5316\u7684\u4e34\u5e8a\u8bd5\u9a8c\u3002\u6570\u636e\u5c55\u793a\u4e86\u76f8\u5e94\u4e34\u5e8a\u8bd5\u9a8c\u7684\u6570\u91cf\u548c\u767e\u5206\u6bd4\u3002<\/p><\/div>\n<p><span dir=\"auto\">\u4f8b\u5982\uff0cBM-MSC\u7684\u6570\u91cf\u548c\u5206\u5316\u6f5c\u80fd\u4f1a\u968f\u7740\u5e74\u9f84\u7684\u589e\u957f\u800c\u4e0b\u964d<\/span><span dir=\"auto\">\u3002\u4e0eBM-MSC\u76f8\u6bd4\uff0c\u8110\u5e26\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08UC-MSC\uff09\u5177\u6709\u8bf8\u591a\u4f18\u52bf\u3002\u5b83\u4eec\u6613\u4e8e\u83b7\u53d6\uff0c\u4e14\u6613\u4e8e\u6269\u589e\u81f3\u6240\u9700\u6570\u91cf\u3002UC-MSC\u5904\u4e8e\u5668\u5b98\u53d1\u80b2\u7684\u65e9\u671f\u9636\u6bb5\uff0c\u5e76\u8868\u73b0\u51fa\u66f4\u5f3a\u7684\u81ea\u6211\u66f4\u65b0\u548c\u5206\u5316\u80fd\u529b<\/span><span dir=\"auto\">\u3002UC-MSC\u7684\u809d\u5206\u5316\u6f5c\u80fd\u9ad8\u4e8eBM-MSC\uff0c\u8fd9\u8868\u660eUC-MSC\u5728\u6cbb\u7597\u7ec8\u672b\u671f\u809d\u75c5\u65b9\u9762\u53ef\u80fd\u4f18\u4e8eBM-MSC<\/span><span dir=\"auto\">\u3002\u6b64\u5916\uff0c\u8110\u5e26\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08UC-MSCs\uff09\u7684\u514d\u75ab\u539f\u6027\u4f4e\u4e8e\u9aa8\u9ad3\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08BOM-MSCs\uff09<\/span><span dir=\"auto\">\u3002\u8102\u80aa\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08AD-MSCs\uff09\u4e5f\u6613\u4e8e\u83b7\u53d6\uff0c\u4f46\u8fd9\u4e9b\u7ec6\u80de\u589e\u6b96\u80fd\u529b\u548c\u6297\u708e\u80fd\u529b\u8f83\u5dee<\/span><span dir=\"auto\">\u3002\u56e0\u6b64\uff0c<strong>UC-MSCs\u4f3c\u4e4e\u662f\u79fb\u690d\u7684\u6700\u4f73\u9009\u62e9<\/strong>The<\/span><\/p>\n<p><span dir=\"auto\">\u81ea\u4f53\u79fb\u690d\u8fd8\u662f\u5f02\u4f53\u79fb\u690d\u662f\u533b\u751f\u9762\u4e34\u7684\u53e6\u4e00\u4e2a\u96be\u9898\u3002\u4ece\u4e34\u5e8a\u8bd5\u9a8c\u6570\u636e\u53ef\u4ee5\u770b\u51fa\uff0c<strong>\u81ea\u4f53\u79fb\u690d\u591a\u4e8e\u5f02\u4f53\u79fb\u690d\uff08\u56fe<\/strong><\/span><strong><span dir=\"auto\">4B<\/span><\/strong><span dir=\"auto\"><strong>\uff09<\/strong>\u3002\u7136\u800c\uff0c\u7531\u4e8e\u8110\u5e26\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08UC-MSCs\uff09\u7684\u4f18\u52bf\uff0c\u5f02\u4f53\u79fb\u690d\u53ef\u80fd\u4f18\u4e8e\u81ea\u4f53\u79fb\u690d\u3002\u4f9b\u4f53\u5dee\u5f02\uff08\u5e74\u9f84\u3001\u6027\u522b\u3001\u9057\u4f20\u56e0\u7d20\u548c\u5065\u5eb7\u72b6\u51b5\uff09\u662f\u5f71\u54cd\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09\u4e34\u5e8a\u7597\u6548\u7684\u91cd\u8981\u56e0\u7d20<\/span><span dir=\"auto\">\u3002\u4e0e\u6210\u4eba\u7ec4\u7ec7\u6765\u6e90\u7684MSCs\u76f8\u6bd4\uff0c\u65b0\u751f\u513f\u7ec4\u7ec7\u6765\u6e90\u7684MSCs\u5177\u6709\u66f4\u957f\u7684\u6d3b\u6027\u5bff\u547d\u548c\u66f4\u597d\u7684\u589e\u6b96\u548c\u5206\u5316\u6f5c\u80fd\u3002\u6b64\u5916\uff0c\u6765\u81ea\u4e0d\u5065\u5eb7\u4f9b\u4f53\u7684MSCs\u53ef\u80fd\u5bfc\u81f4\u4e0d\u826f\u7684\u4e34\u5e8a\u7ed3\u679c<\/span><span dir=\"auto\">The<\/span><\/p>\n<h3><span class=\"ez-toc-section\" id=\"%E7%BB%86%E8%83%9E%E5%88%B6%E5%A4%87\"><\/span>\u7ec6\u80de\u5236\u5907<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p class=\"ds-markdown-paragraph\"><strong>\u5206\u79bb\u65b9\u6cd5\u4e0e\u6765\u6e90\u7684\u6807\u51c6\u5316\u662f\u7597\u6548\u4e00\u81f4\u6027\u7684\u57fa\u7840<\/strong><\/p>\n<p class=\"ds-markdown-paragraph\">\u7ec6\u80de\u5236\u5907\u7684\u9996\u8981\u73af\u8282\u2014\u2014\u5206\u79bb\u65b9\u6cd5\uff0c\u662f\u5bfc\u81f4\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u4ea7\u54c1\u6548\u529b\u5dee\u5f02\u7684\u5173\u952e\u56e0\u7d20\u3002\u5373\u4f7f\u4f7f\u7528\u540c\u4e00\u79cd\u7ec4\u7ec7\uff08\u5982\u8110\u5e26\uff09\uff0c\u4e0d\u540c\u7684\u5206\u79bb\u6280\u672f\u3001\u53d6\u6750\u90e8\u4f4d\uff08\u5982\u662f\u5426\u5305\u542b\u8840\u7ba1\u5468\u56f4\u7ec4\u7ec7\uff09\u90fd\u4f1a\u663e\u8457\u5f71\u54cd\u6240\u5f97\u7ec6\u80de\u7684\u529f\u80fd\u4e0e\u5206\u5b50\u7279\u5f81\u3002\u7814\u7a76\u8868\u660e\uff0c\u5373\u4f7f\u8d77\u59cb\u6750\u6599\u76f8\u540c\uff0c\u4e0d\u540c\u5b9e\u9a8c\u5ba4\u6216\u751f\u4ea7\u4e2d\u5fc3\u5236\u5907\u51fa\u7684\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u5728\u6548\u529b\u548c\u7279\u6027\u4e0a\u4e5f\u5b58\u5728\u5dee\u5f02\uff0c\u8fd9\u7a81\u663e\u4e86\u5efa\u7acb\u5168\u7403\u7edf\u4e00\u7684\u7ec6\u80de\u5206\u79bb\u4e0e\u6269\u589e\u6807\u51c6\u7684\u6781\u7aef\u91cd\u8981\u6027\uff0c\u4ee5\u4fdd\u969c\u6cbb\u7597\u4ea7\u54c1\u7684\u53ef\u91cd\u590d\u6027\u548c\u53ef\u9760\u6027\u3002<\/p>\n<p class=\"ds-markdown-paragraph\"><strong>\u57f9\u517b\u6761\u4ef6\u7684\u4f18\u5316\uff1a\u4ece\u5b9e\u9a8c\u5ba4\u5230\u4e34\u5e8a\u7684\u5173\u952e\u8f6c\u5316\u53c2\u6570<\/strong><\/p>\n<p class=\"ds-markdown-paragraph\">\u4f53\u5916\u57f9\u517b\u6761\u4ef6\u662f\u7ef4\u6301\u548c\u5851\u9020\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u529f\u80fd\u7684\u6838\u5fc3\u3002\u4f20\u7edf\u79d1\u7814\u4e2d\u5e38\u7528\u7684\u80ce\u725b\u8840\u6e05\u56e0\u5176\u5b58\u5728\u75c5\u539f\u4f53\u98ce\u9669\u3001\u514d\u75ab\u539f\u6027\u53ca\u6279\u6b21\u5dee\u5f02\u7b49\u95ee\u9898\uff0c\u4e0d\u9002\u7528\u4e8e\u4e34\u5e8a\u7ea7\u7ec6\u80de\u751f\u4ea7\u3002\u65e0\u8840\u6e05\u3001\u5316\u5b66\u6210\u5206\u660e\u786e\u7684\u57f9\u517b\u57fa\u6210\u4e3a\u66f4\u5b89\u5168\u3001\u53ef\u63a7\u7684\u66ff\u4ee3\u9009\u62e9\u3002\u6b64\u5916\uff0c\u57f9\u517b\u73af\u5883\u4e2d\u7684\u6c27\u6d53\u5ea6\u662f\u53e6\u4e00\u4e2a\u5173\u952e\u53c2\u6570\uff0c\u6a21\u62df\u4f53\u5185\u751f\u7406\u4f4e\u6c27\u6761\u4ef6\uff081%-7%\uff09\u7684\u57f9\u517b\uff0c\u76f8\u8f83\u4e8e\u5e38\u6c27\uff0820%\uff09\uff0c\u80fd\u66f4\u597d\u5730\u7ef4\u6301\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u7684\u589e\u6b96\u3001\u5f52\u5de2\u3001\u6297\u51cb\u4ea1\u7b49\u6cbb\u7597\u6f5c\u80fd\uff0c\u5e76\u51cf\u5c11\u5176\u81ea\u53d1\u5206\u5316\u3002<\/p>\n<p class=\"ds-markdown-paragraph\"><strong>\u51b7\u51bb\u4fdd\u5b58\u3001\u7ec6\u80de\u5f02\u8d28\u6027\u4e0e\u8d28\u91cf\u63a7\u5236\uff1a\u786e\u4fdd\u4e34\u5e8a\u4ea7\u54c1\u7684\u7a33\u5b9a\u6027<\/strong><\/p>\n<p class=\"ds-markdown-paragraph\">\u51b7\u51bb\u4fdd\u5b58\u4e0e\u590d\u82cf\u8fc7\u7a0b\u4f1a\u635f\u5bb3\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u7684\u514d\u75ab\u6291\u5236\u529f\u80fd\uff0c\u5e76\u6539\u53d8\u5176\u8f93\u6ce8\u540e\u7684\u4f53\u5185\u884c\u4e3a\uff0c\u89e3\u51bb\u540e\u7ec6\u80de\u9700\u8981\u4e00\u6bb5\u6062\u590d\u671f\u624d\u80fd\u5b8c\u5168\u6062\u590d\u6d3b\u6027\u3002\u6b64\u5916\uff0c\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u4ea7\u54c1\u5b58\u5728\u56fa\u6709\u7684\u5f02\u8d28\u6027\uff0c\u6e90\u4e8e\u4f9b\u4f53\u5dee\u5f02\u3001\u7ec4\u7ec7\u6765\u6e90\u53ca\u5236\u5907\u8fc7\u7a0b\u3002\u4e3a\u63a7\u5236\u8d28\u91cf\uff0c\u7814\u7a76\u6b63\u63a2\u7d22\u4f7f\u7528\u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de\u6765\u6e90\u7684\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u4ee5\u83b7\u5f97\u66f4\u5747\u4e00\u7684\u7ec6\u80de\u7fa4\uff0c\u5e76\u5173\u6ce8\u4f20\u4ee3\u6b21\u6570\uff08\u957f\u671f\u6269\u589e\u4f1a\u5bfc\u81f4\u529f\u80fd\u8870\u9000\uff09\u548c\u57f9\u517b\u7cfb\u7edf\uff08\u5982\u4e09\u7ef4\u57f9\u517b\uff09\u5bf9\u7ec6\u80de\u7279\u6027\u7684\u5f71\u54cd\u3002\u540c\u65f6\uff0c\u9700\u901a\u8fc7\u6d41\u5f0f\u7ec6\u80de\u672f\u7b49\u65b9\u6cd5\u9274\u522b\u5e76\u6392\u9664\u53ef\u80fd\u6df7\u6742\u7684\u6210\u7ea4\u7ef4\u7ec6\u80de\u3002\u56e0\u6b64\uff0c\u7efc\u5408\u8003\u8651\u5e76\u4f18\u5316\u6240\u6709\u8fd9\u4e9b\u53c2\u6570\uff0c\u5236\u5b9a\u6807\u51c6\u5316\u5236\u5907\u6d41\u7a0b\uff0c\u662f\u786e\u4fdd\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u7597\u6cd5\u6210\u529f\u4e34\u5e8a\u8f6c\u5316\u7684\u57fa\u77f3\u3002<\/p>\n<h3 id=\"Sec28\" class=\"c-article__sub-heading c-article__sub-heading--small\"><span class=\"ez-toc-section\" id=\"%E7%A7%BB%E6%A4%8D%E9%80%94%E5%BE%84\"><\/span><span dir=\"auto\">\u79fb\u690d\u9014\u5f84<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span dir=\"auto\">\u5728\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSC\uff09\u79fb\u690d\u91c7\u7528\u4e86\u591a\u79cd\u690d\u5165\u9014\u5f84\uff0c\u4e3b\u8981\u9014\u5f84\u662f\u809d\u52a8\u8109\uff0c\u5176\u6b21\u662f\u9759\u8109\u6ce8\u5c04\u548c\u95e8\u9759\u8109\u6ce8\u5c04\uff08\u56fe<\/span><span dir=\"auto\">4C<\/span><span dir=\"auto\">\uff09\u3002\u4e5f\u6709\u4e34\u5e8a\u8bd5\u9a8c\u5c1d\u8bd5\u7ecf\u813e\u5185\u9014\u5f84\u79fb\u690dMSC<\/span><span dir=\"auto\">\u3002\u76ee\u524d\u5c1a\u96be\u65ad\u5b9a\u54ea\u79cd\u9014\u5f84\u6700\u4f73\u3002\u4e00\u9879\u5173\u4e8e\u6025\u6027\u809d\u8870\u7aed\u7684\u7814\u7a76\u8868\u660e\uff0c\u95e8\u9759\u8109\u6ce8\u5c04\u5728\u4fee\u590d\u809d\u635f\u4f24\u65b9\u9762\u4f18\u4e8e\u809d\u52a8\u8109\u6ce8\u5c04\u3001\u5916\u5468\u9759\u8109\u8f93\u6ce8\u548c\u539f\u4f4d\u809d\u5185\u6ce8\u5c04<\/span><span dir=\"auto\">\u3002\u9057\u61be\u7684\u662f\uff0c\u76ee\u524d\u5c1a\u65e0\u9488\u5bf9\u809d\u786c\u5316\u7684\u7c7b\u4f3c\u7814\u7a76\u3002\u56e0\u6b64\uff0c\u6211\u4eec\u65e0\u6cd5\u901a\u8fc7\u6bd4\u8f83\u4e0d\u540c\u7684\u7814\u7a76\u5f97\u51fa\u7ed3\u8bba\u3002<\/span><\/p>\n<p><span dir=\"auto\">\u8003\u8651\u5230\u4fbf\u5229\u6027\u548c\u526f\u4f5c\u7528\uff0c\u9759\u8109\u6ce8\u5c04\u662f\u6700\u4fbf\u6377\u3001\u6700\u5b89\u5168\u7684\u7ed9\u836f\u9014\u5f84\u3002\u7136\u800c\uff0c\u52a8\u7269\u5b9e\u9a8c\u8868\u660e\uff0c\u7ea660%\u7684\u7ec6\u80de\u4f1a\u79ef\u805a\u5728\u80ba\u90e8\u5e76\u88ab\u514d\u75ab\u7cfb\u7edf\u6e05\u9664<\/span><span dir=\"auto\">\u3002\u56e0\u6b64\uff0c\u5982\u679c\u91c7\u7528\u9759\u8109\u6ce8\u5c04\uff0c\u5219\u9700\u8981\u5236\u5907\u66f4\u591a\u7684\u7ec6\u80de\u3002\u95e8\u9759\u8109\u3001\u809d\u5185\u548c\u813e\u5185\u6ce8\u5c04\u53ef\u4ee5\u66f4\u5feb\u5730\u9012\u9001\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff0c\u5e76\u907f\u514d\u8131\u9776\u6548\u5e94\u3002\u4f46\u662f\uff0c\u6211\u4eec\u5e94\u8be5\u8003\u8651\u5230\u6bcf\u79cd\u6ce8\u5c04\u9014\u5f84\u7684\u5e76\u53d1\u75c7\u3002\u8fd9\u4e9b\u6ce8\u5c04\u9014\u5f84\u90fd\u9700\u8981\u624b\u672f\uff0c\u4f1a\u9020\u6210\u521b\u4f24\uff0c\u5e76\u4e14\u90e8\u5206\u60a3\u8005\u4f1a\u51fa\u73b0\u53d1\u70ed<\/span><span dir=\"auto\">\u3002\u60a3\u8005\u7684\u4e2a\u4f53\u60c5\u51b5\u4e5f\u9700\u8981\u8003\u8651\u3002\u56e0\u6b64\uff0c\u5f88\u96be\u786e\u5b9a\u54ea\u79cd\u7ed9\u836f\u9014\u5f84\u662f\u6700\u4f73\u7684\u3002\u5982\u4f55\u9009\u62e9\u6ce8\u5c04\u9014\u5f84\u5e94\u53d6\u51b3\u4e8e\u6bcf\u4f4d\u60a3\u8005\u7684\u7efc\u5408\u60c5\u51b5\u3002<\/span><\/p>\n<h3 id=\"Sec29\" class=\"c-article__sub-heading c-article__sub-heading--small\"><span class=\"ez-toc-section\" id=\"%E5%89%82%E9%87%8F\"><\/span><span dir=\"auto\">\u5242\u91cf<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span dir=\"auto\">\u76ee\u524d\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSC\uff09\u79fb\u690d\u7684\u5242\u91cf\u9009\u62e9\u6781\u4e0d\u7edf\u4e00\u3002<strong>\u5927\u591a\u6570\u4e34\u5e8a\u8bd5\u9a8c\u6839\u636e\u60a3\u8005\u4f53\u91cd\u8fdb\u884cMSC\u79fb\u690d\uff080.5\u20134 \u00d7 10\u2076<\/strong><\/span><strong><sub><span dir=\"auto\">\/<\/span><\/sub><\/strong><span dir=\"auto\"><strong>\u00a0kg\uff09<\/strong>\uff0c\u800c\u5176\u4ed6\u4e34\u5e8a\u8bd5\u9a8c\u5219\u6839\u636e\u7ec6\u80de\u6570\u91cf\uff08<sup>1 \u00d7 10\u2077\u00a0<\/sup><\/span><sup><span dir=\"auto\">\u2013<\/span><span dir=\"auto\">\u00a05 \u00d7\u00a0<\/span><span dir=\"auto\">10\u2078\u4e2a<\/span><\/sup><span dir=\"auto\">\u7ec6\u80de\uff09\u8fdb\u884c\u7ed9\u836f\u3002MSC\u7597\u6cd5\u662f\u5426\u5e94\u9075\u5faa\u5176\u4ed6\u836f\u7269\u7684\u7ed9\u836f\u7b56\u7565\u503c\u5f97\u63a2\u8ba8\u3002\u4e00\u4e9b\u4e34\u5e8a\u8bd5\u9a8c\u5df2\u7740\u91cd\u7814\u7a76\u4e86\u4e0d\u540c\u5242\u91cf\u7684\u7597\u6548\uff0c\u4f46\u5c1a\u672a\u516c\u5e03\u76f8\u5173\u6570\u636e\uff08NCT02705742\u3001NCT03626090\u3001NCT05080465\u3001NCT05227846\u3001NCT05155657\uff09\u3002\u7136\u800c\uff0c\u6839\u636e\u5df2\u53d1\u8868\u7684\u6570\u636e\uff0c\u6211\u4eec\u53ef\u4ee5\u770b\u5230\uff0c<strong>\u813e\u5185\u6ce8\u5c041 \u00d7 10\u2077\u4e2a\u7ec6\u80de\u5373\u53ef\u5bf9\u809d\u786c\u5316\u60a3\u8005\u4ea7\u751f\u660e\u663e\u7684\u6cbb\u7597\u6548\u679c<\/strong>\uff0c\u4e14\u7597\u6548\u53ef\u6301\u7eed6\u4e2a\u6708<\/span><span dir=\"auto\">The<\/span><\/p>\n<p><span dir=\"auto\">\u5927\u591a\u6570\u4e34\u5e8a\u8bd5\u9a8c\u91c7\u7528\u5355\u6b21\u79fb\u690d\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09\u7684\u65b9\u5f0f\uff0c\u800c\u53e6\u4e00\u4e9b\u8bd5\u9a8c\u5219\u91c7\u7528\u591a\u6b21\u79fb\u690d\u7684\u65b9\u5f0f\uff0c\u6bcf\u6b21\u79fb\u690d2\u81f34\u6b21\uff0c\u95f4\u9694\u65f6\u95f4\u5404\u4e0d\u76f8\u540c\u3002\u4e00\u9879II\u671f\u7814\u7a76\u6bd4\u8f83\u4e86\u5355\u6b21\u79fb\u690d\u548c\u95f4\u9694\u4e00\u4e2a\u6708\u8fdb\u884c\u4e24\u6b21\u79fb\u690d\u7684\u6548\u679c\u3002\u7ed3\u679c\u663e\u793a\uff0c\u5355\u6b21\u79fb\u690d\u548c\u4e24\u6b21\u79fb\u690d\u4e4b\u95f4\u65e0\u663e\u8457\u5dee\u5f02<\/span><span dir=\"auto\">\u3002\u53e6\u4e00\u9879\u7814\u7a76\u8868\u660e\uff0c\u5355\u6b21\u79fb\u690dMSCs\u53ef\u6539\u5584\u809d\u529f\u80fd\uff0c\u968f\u8bbf\u65f6\u95f4\u957f\u8fbe\u4e24\u5e74\u3002\u4f46\u4e24\u5e74\u540e\u672a\u89c2\u5bdf\u5230\u663e\u8457\u7684\u6cbb\u7597\u6548\u679c<\/span><span dir=\"auto\">\u3002\u6709\u62a5\u9053\u79f0\uff0c\u5728\u52a8\u7269\u5b9e\u9a8c\u4e2d\uff0c\u591a\u6b21\u8f93\u6ce8MSCs\u53ef\u80fd\u589e\u5f3a\u79fb\u690d\u6548\u679c<\/span><span dir=\"auto\">\u3002\u57fa\u4e8e\u8fd9\u4e9b\u7814\u7a76\uff0c<strong>\u591a\u6b21\u6ce8\u5c04\u5e76\u5ef6\u957f\u95f4\u9694\u65f6\u95f4\u53ef\u80fd\u6709\u5229\u4e8e\u63d0\u9ad8MSCs\u7684\u6cbb\u7597\u6548\u679c<\/strong>The<\/span><\/p>\n<h3 id=\"Sec30\" class=\"c-article__sub-heading c-article__sub-heading--small\"><span class=\"ez-toc-section\" id=\"%E6%82%A3%E8%80%85%E7%97%85%E6%83%85\"><\/span><span dir=\"auto\">\u60a3\u8005\u75c5\u60c5<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span dir=\"auto\">\u6211\u4eec\u6ce8\u610f\u5230\uff0c\u5728\u4e34\u5e8a\u8bd5\u9a8c\u548c\u5df2\u53d1\u8868\u7684\u4e34\u5e8a\u6587\u7ae0\u4e2d\uff0c\u6ca1\u6709\u7814\u7a76\u6839\u636e\u60a3\u8005\u7684\u75c5\u60c5\u8fdb\u884c\u5206\u7ec4\u3002\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09\u7684\u7279\u6027\uff0c\u5305\u62ec\u8fc1\u79fb\u3001\u5206\u5316\u548c\u514d\u75ab\u8c03\u8282\uff0c\u4f1a\u53d7\u5230\u5176\u5fae\u73af\u5883\u7684\u663e\u8457\u5f71\u54cd\u3002MSCs\u4e0e\u5fae\u73af\u5883\uff0c\u5c24\u5176\u662f\u708e\u75c7\u5fae\u73af\u5883\uff0c\u5b58\u5728\u5927\u91cf\u7684\u76f8\u4e92\u4f5c\u7528\u548c\u4e32\u6270<\/span><span dir=\"auto\">\u3002\u56e0\u6b64\uff0c\u60a3\u8005\u7684\u5fae\u73af\u5883\u662f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u9700\u8981\u8003\u8651\u7684\u5173\u952e\u53c2\u6570\u3002\u809d\u786c\u5316\u7684\u75c5\u56e0\u3001\u708e\u75c7\u7a0b\u5ea6\u3001\u809d\u529f\u80fd\u548c\u6cbb\u7597\u7b56\u7565\u90fd\u4f1a\u5f71\u54cd\u60a3\u8005\u7684\u5fae\u73af\u5883<\/span><span dir=\"auto\">\u3002\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c<strong>\u60a3\u8005\u5e74\u9f84\u662f\u53e6\u4e00\u4e2a\u5df2\u88ab\u8bc1\u5b9e\u4f1a\u5f71\u54cdMSCs\u6cbb\u7597\u6548\u679c\u7684\u91cd\u8981\u53c2\u6570<\/strong><\/span><span dir=\"auto\">The<\/span><\/p>\n<p><span dir=\"auto\">\u57fa\u4e8e\u52a8\u7269\u5b9e\u9a8c\u6570\u636e\uff0c\u6211\u4eec\u8fd8\u53ef\u4ee5\u770b\u5230\uff0c\u5bbf\u4e3b\u7684\u5e74\u9f84\u4f1a\u5bf9\u4eba\u9aa8\u9ad3\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08hMDSC\uff09\u4ecb\u5bfc\u7684\u9aa8\u518d\u751f\u4ea7\u751f\u4e0d\u5229\u5f71\u54cd<\/span><span dir=\"auto\">\u3002\u5927\u591a\u6570\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u5165\u7ec4\u60a3\u8005\u7684\u5e74\u9f84\u8303\u56f4\u7ea6\u4e3a18-30\u5c81\u81f365-80\u5c81\uff08<\/span><a href=\"http:\/\/clinicaltrials.gov\/\" rel=\"nofollow noopener\" target=\"_blank\"><span dir=\"auto\">clinicaltrials.gov<\/span><\/a><span dir=\"auto\">\uff09\u3002\u8fd9\u4e00\u5e74\u9f84\u8de8\u5ea6\u8fc7\u5927\uff0c\u5bfc\u81f4\u540c\u4e00\u7ec4\u5185\u4e0d\u540c\u5e74\u9f84\u6bb5\u60a3\u8005\u7684\u5fae\u73af\u5883\u5b58\u5728\u663e\u8457\u5dee\u5f02\u3002\u8870\u8001\u5fae\u73af\u5883\uff0c\u5305\u62ec\u8870\u8001\u76f8\u5173\u5206\u6ccc\u8868\u578b\uff08SASP\uff09\uff0c\u5df2\u88ab\u8bc1\u5b9e\u4f1a\u635f\u5bb3\u79fb\u690d\u7684\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09\u7684\u529f\u80fd<\/span><span dir=\"auto\">\u3002\u5982\u679c\u5c06\u60a3\u8005\u6309\u8f83\u7a84\u7684\u5e74\u9f84\u8303\u56f4\u5206\u7ec4\uff0c\u6211\u4eec\u53ef\u4ee5\u83b7\u5f97\u66f4\u51c6\u786e\u7684\u7ed3\u679c\u3002<\/span><\/p>\n<p><span dir=\"auto\">\u6211\u4eec\u4e4b\u524d\u7684\u4e00\u9879\u7814\u7a76\u53d1\u73b0\uff0c\u6162\u6027\u5e94\u6fc0\u4f1a\u6291\u5236\u5c0f\u9f20\u6a21\u578b\u4e2dMSCs\u7684\u6cbb\u7597\u6548\u679c<\/span><span dir=\"auto\">\u3002\u53e6\u4e00\u9879\u7814\u7a76\u8868\u660e\uff0c\u5730\u585e\u7c73\u677e\uff08DEX\uff09\u4f1a\u6d88\u9664MSCs\u5bf9\u7ea4\u7ef4\u86cb\u767d\u6c89\u79ef\u3001\u8840\u6e05\u80c6\u7ea2\u7d20\u3001\u767d\u86cb\u767d\u548c\u6c28\u57fa\u8f6c\u79fb\u9176\u6c34\u5e73\u4ee5\u53caT\u6dcb\u5df4\u7ec6\u80de\u6d78\u6da6\u7684\u6cbb\u7597\u4f5c\u7528<\/span><span dir=\"auto\">\u3002\u7efc\u5408\u8003\u8651\u60a3\u8005\u7684\u5404\u9879\u60c5\u51b5\u548c\u6cbb\u7597\u6548\u679c\uff0c\u6211\u4eec\u53ef\u4ee5\u5728\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u79fb\u690d\u524d\u8bc4\u4f30\u60a3\u8005\u662f\u5426\u9002\u5408\u63a5\u53d7\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6cbb\u7597\u3002\u6211\u4eec\u8fd8\u53ef\u4ee5\u91c7\u53d6\u63aa\u65bd\uff0c\u4f7f\u60a3\u8005\u4fdd\u6301\u6700\u4f73\u72b6\u6001\u4ee5\u63a5\u53d7\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u79fb\u690d\u3002<\/span><\/p>\n<h2><span class=\"ez-toc-section\" id=\"%E7%BB%93%E8%AE%BA\"><\/span>reach a verdict<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<\/div>\n<p class=\"ds-markdown-paragraph\"><strong>\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u5728\u809d\u7ea4\u7ef4\u5316\u4e2d\u626e\u6f14\u77db\u76fe\u7684\u53cc\u91cd\u89d2\u8272\uff1a\u65e2\u662f\u75c5\u7406\u53c2\u4e0e\u8005\uff0c\u4e5f\u662f\u6cbb\u7597\u6267\u884c\u8005\u3002<\/strong>\u00a0\u4e00\u65b9\u9762\uff0c\u809d\u810f\u5185\u6e90\u6027\u7684\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u5728\u6162\u6027\u635f\u4f24\u7684\u5fae\u73af\u5883\u4e2d\uff0c\u53ef\u88ab\u8f6c\u5316\u4e3a\u808c\u6210\u7ea4\u7ef4\u7ec6\u80de\u6216\u4fc3\u8fdb\u809d\u661f\u72b6\u7ec6\u80de\u6d3b\u5316\uff0c\u4ece\u800c\u76f4\u63a5\u9a71\u52a8\u7ea4\u7ef4\u5316\u8fdb\u5c55\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u5916\u6e90\u6027\u79fb\u690d\u7684\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u5219\u5c55\u73b0\u51fa\u5f3a\u5927\u7684\u6cbb\u7597\u6f5c\u80fd\uff0c\u5176\u901a\u8fc7\u5206\u5316\u4e3a\u809d\u7ec6\u80de\u3001\u4fdd\u62a4\u53d7\u635f\u809d\u7ec6\u80de\u3001\u6291\u5236\u661f\u72b6\u7ec6\u80de\u6d3b\u5316\u3001\u5206\u6ccc\u6297\u7ea4\u7ef4\u5316\u56e0\u5b50\u53ca\u8fdb\u884c\u514d\u75ab\u8c03\u8282\u7b49\u591a\u91cd\u673a\u5236\uff0c\u5171\u540c\u7f13\u89e3\u7ea4\u7ef4\u5316\u5e76\u4fc3\u8fdb\u809d\u529f\u80fd\u6062\u590d\u3002\u8fd9\u79cd\u77db\u76fe\u7684\u6838\u5fc3\u5728\u4e8e\u7ec6\u80de\u6240\u5904\u5fae\u73af\u5883\u7684\u4e0d\u540c\uff1a\u957f\u671f\u7684\u75c5\u7406\u5fae\u73af\u5883\u91cd\u5851\u4e86\u5185\u6e90\u6027\u7ec6\u80de\u7684\u529f\u80fd\uff0c\u800c\u5916\u6e90\u6027\u79fb\u690d\u5219\u4e3b\u52a8\u5f15\u5165\u4e86\u4e00\u4e2a\u4fee\u590d\u6027\u7684\u8c03\u63a7\u529b\u91cf\u3002<\/p>\n<p 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