{"id":20730,"date":"2025-12-02T17:43:05","date_gmt":"2025-12-02T09:43:05","guid":{"rendered":"https:\/\/www.hjtdsm.cn\/?p=20730"},"modified":"2025-12-02T17:43:45","modified_gmt":"2025-12-02T09:43:45","slug":"https-www-hjtdsm-cn-stem-cells-stem-cell-therapy-20730-html","status":"publish","type":"post","link":"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/20730.html","title":{"rendered":"\u8de8\u8d8a\u74f6\u9888\uff0c\u8fce\u63a5\u66d9\u5149\uff1a\u76d8\u70b9\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6cbb\u7597\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u7684\u8001\u95ee\u9898\u4e0e\u65b0\u673a\u9047"},"content":{"rendered":"<section data-role=\"list\">\n<section data-role=\"list\" data-pm-slice=\"4 4 [&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;outer&quot;,&quot;label&quot;:&quot;edit by 135editor&quot;,&quot;data-pm-slice&quot;:&quot;0 0 []&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;paragraph&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;}]\">\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\uff0c\u5982<span class=\"\">senile dementia<\/span>\u3001\u5e15\u91d1\u68ee\u75c5\u3001\u4e2d\u98ce\u548c\u810a\u9ad3\u635f\u4f24\uff0c\u4e00\u76f4\u662f\u4eba\u7c7b\u5065\u5eb7\u7684\u91cd\u5927\u5a01\u80c1\uff0c\u7ed9\u60a3\u8005\u53ca\u5176\u5bb6\u5ead\u5e26\u6765\u6c89\u91cd\u7684\u8d1f\u62c5\u3002\u8fd1\u5e74\u6765\uff0c\u968f\u7740\u518d\u751f\u533b\u5b66\u7684\u5feb\u901f\u53d1\u5c55\uff0c<span class=\"\">mesenchymal stem cell MSC (in cell biology)<\/span>\u5728\u5352\u4e2d\u3001\u591a\u53d1\u6027\u786c\u5316\u75c7\u3001\u810a\u9ad3\u635f\u4f24\u548c\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u7684\u4e34\u5e8a\u524d\u53ca\u4e34\u5e8a\u7814\u7a76\u4e2d\uff0c\u53d6\u5f97\u4e86\u4ee4\u4eba\u9f13\u821e\u7684\u8fdb\u5c55\uff0c\u5c55\u73b0\u51fa\u5de8\u5927\u7684\u6cbb\u7597\u6f5c\u529b\u3002\u8fd1\u671f\uff0c\u300a<span class=\"\">Biologics<\/span>\u300b\u671f\u520a\u4e0a\u53d1\u8868\u4e86\u4e00\u7bc7\u9898\u4e3a\u201c<a href=\"https:\/\/www.mdpi.com\/2673-8449\/5\/4\/37\" target=\"_blank\" rel=\"noopener nofollow\">\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u53ca\u5176\u884d\u751f\u7269\uff1a\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u518d\u751f\u533b\u5b66\u4e2d\u7684\u8001\u95ee\u9898\u4e0e\u65b0\u673a\u9047<\/a>\u201d\u7684\u7efc\u8ff0\u6587\u7ae0\uff0c\u7cfb\u7edf\u6027\u5730\u9610\u8ff0\u4e86\u8be5\u9886\u57df\u7684\u6700\u65b0\u52a8\u6001[1]\u3002<\/p>\n<section><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter 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\/><\/section>\n<p>\u672c\u6587\u57fa\u4e8e\u6b64\uff0c\u65e8\u5728\u76d8\u70b9\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6cbb\u7597\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u7684\u8001\u95ee\u9898\u4e0e\u65b0\u673a\u9047\uff0c\u91cd\u70b9\u5206\u6790\u5f53\u524d\u9762\u4e34\u7684\u6838\u5fc3\u6311\u6218\uff0c\u5e76\u5c55\u671b\u65e8\u5728\u7a81\u7834\u8fd9\u4e9b\u74f6\u9888\u7684\u65b0\u5174\u6280\u672f\u7b56\u7565\u3002\u6211\u4eec\u7684\u5206\u6790\u7efc\u5408\u4e862015\u5e74\u81f32025\u5e74\u95f4PubMed\u548cScopus\u6570\u636e\u5e93\u6536\u5f55\u7684\u6587\u732e\uff0c\u5e76\u91cd\u70b9\u5173\u6ce8\u4e86ClinicalTrials.gov\u7f51\u7ad9\u4e0a\u7684\u76f8\u5173\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/p>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_79_2 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" 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>\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6cbb\u7597\u810a\u9ad3\u635f\u4f24\u7684\u4e34\u5e8a\u6848\u4f8b<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/20730.html\/#%E9%97%B4%E5%85%85%E8%B4%A8%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E9%98%BF%E5%B0%94%E8%8C%A8%E6%B5%B7%E9%BB%98%E7%97%85%E7%9A%84%E4%B8%B4%E5%BA%8A%E6%A1%88%E4%BE%8B\" >\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6cbb\u7597\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u4e34\u5e8a\u6848\u4f8b<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/20730.html\/#%E9%97%B4%E5%85%85%E8%B4%A8%E5%B9%B2%E7%BB%86%E8%83%9E%E6%9D%A5%E6%BA%90%E5%A4%96%E6%B3%8C%E4%BD%93%E6%B2%BB%E7%96%97%E7%A5%9E%E7%BB%8F%E7%B3%BB%E7%BB%9F%E7%96%BE%E7%97%85%E7%9A%84%E4%B8%B4%E5%BA%8A%E7%A0%94%E7%A9%B6\" >\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6765\u6e90\u5916\u6ccc\u4f53\u6cbb\u7597\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u7684\u4e34\u5e8a\u7814\u7a76<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/20730.html\/#%E9%97%B4%E5%85%85%E8%B4%A8%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E7%A5%9E%E7%BB%8F%E7%B3%BB%E7%BB%9F%E7%96%BE%E7%97%85%E7%9A%84%E6%97%A7%E9%97%AE%E9%A2%98%E4%B8%8E%E6%8C%91%E6%88%98\" >\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6cbb\u7597\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u7684\u65e7\u95ee\u9898\u4e0e\u6311\u6218<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/20730.html\/#%E9%97%B4%E5%85%85%E8%B4%A8%E5%B9%B2%E7%BB%86%E8%83%9E%E5%8F%8A%E5%85%B6%E8%A1%8D%E7%94%9F%E7%89%A9%E6%B2%BB%E7%96%97%E7%A5%9E%E7%BB%8F%E7%B3%BB%E7%BB%9F%E7%96%BE%E7%97%85%E7%9A%84%E6%96%B0%E7%9A%84%E5%8F%AF%E8%83%BD%E6%80%A7%E5%92%8C%E6%96%B9%E6%B3%95\" >\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u53ca\u5176\u884d\u751f\u7269\u6cbb\u7597\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u7684\u65b0\u7684\u53ef\u80fd\u6027\u548c\u65b9\u6cd5<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/20730.html\/#%E7%BB%93%E8%AE%BA\" >reach a verdict<\/a><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"%E9%97%B4%E5%85%85%E8%B4%A8%E5%B9%B2%E7%BB%86%E8%83%9E%E7%9A%84%E6%A0%B8%E5%BF%83%E7%89%B9%E6%80%A7%E4%B8%8E%E6%B2%BB%E7%96%97%E6%BD%9C%E5%8A%9B\"><\/span><strong>\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u7684\u6838\u5fc3\u7279\u6027\u4e0e\u6cbb\u7597\u6f5c\u529b<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><a href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/mscs\/20507.html\/\" target=\"_blank\" rel=\"noopener\">\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09<\/a>\u662f\u4e00\u7c7b\u5177\u6709\u591a\u5411\u5206\u5316\u6f5c\u80fd\uff08\u5982\u5206\u5316\u4e3a\u9aa8\u3001\u8f6f\u9aa8\u3001\u8102\u80aa\u7ec6\u80de\uff09\u548c\u5f3a\u5927\u65c1\u5206\u6ccc\u529f\u80fd\u7684\u57fa\u8d28\u7ec6\u80de\u3002\u5176\u6838\u5fc3\u4ef7\u503c\u4e0d\u4ec5\u5728\u4e8e\u5206\u5316\u80fd\u529b\uff0c\u66f4\u5728\u4e8e\u5b83\u4eec\u6240\u5177\u5907\u7684\u663e\u8457<a href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/mscs\/20023.html\/\" target=\"_blank\" rel=\"noopener\">\u514d\u75ab\u8c03\u8282<\/a>\u3001\u6297\u708e\u3001\u4fc3\u8840\u7ba1\u751f\u6210\u53ca\u4fc3\u8fdb\u7ec4\u7ec7\u4fee\u590d\u7684\u7279\u6027\u3002\u8fd9\u4e9b\u7279\u6027\u4f7f\u5176\u6210\u4e3a\u6cbb\u7597\u591a\u79cd\u9000\u884c\u6027\u548c\u708e\u75c7\u6027\u75be\u75c5\uff0c\u5c24\u5176\u662f\u9700\u8981\u795e\u7ecf\u4fdd\u62a4\u548c\u514d\u75ab\u8c03\u8282\u7684\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u7684\u7406\u60f3\u5019\u9009\u8005\u3002<\/p>\n<section><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-20742\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/\u5fae\u4fe1\u56fe\u7247_2025-12-02_115302_586.png\" alt=\"\" width=\"1945\" height=\"704\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/\u5fae\u4fe1\u56fe\u7247_2025-12-02_115302_586.png 1945w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/\u5fae\u4fe1\u56fe\u7247_2025-12-02_115302_586-300x109.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/\u5fae\u4fe1\u56fe\u7247_2025-12-02_115302_586-1024x371.png 1024w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/\u5fae\u4fe1\u56fe\u7247_2025-12-02_115302_586-768x278.png 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/\u5fae\u4fe1\u56fe\u7247_2025-12-02_115302_586-1536x556.png 1536w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/\u5fae\u4fe1\u56fe\u7247_2025-12-02_115302_586-18x7.png 18w\" sizes=\"(max-width: 1945px) 100vw, 1945px\" \/><\/section>\n<h2><span class=\"ez-toc-section\" id=\"%E6%B2%BB%E7%96%97%E6%9C%BA%E5%88%B6%E7%9A%84%E8%8C%83%E5%BC%8F%E8%BD%AC%E5%8F%98%EF%BC%9A%E4%BB%8E%E7%BB%86%E8%83%9E%E6%9B%BF%E4%BB%A3%E5%88%B0%E5%9B%8A%E6%B3%A1%E9%80%92%E9%80%81\"><\/span><strong>\u6cbb\u7597\u673a\u5236\u7684\u8303\u5f0f\u8f6c\u53d8\uff1a\u4ece\u7ec6\u80de\u66ff\u4ee3\u5230\u56ca\u6ce1\u9012\u9001<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>\u7814\u7a76\u53d1\u73b0\uff0cMSCs\u7684\u6cbb\u7597\u4f5c\u7528\u4e3b\u8981\u5e76\u975e\u901a\u8fc7\u76f4\u63a5\u5206\u5316\u548c\u66ff\u4ee3\u53d7\u635f\u7ec6\u80de\u5b9e\u73b0\uff0c\u800c\u662f\u901a\u8fc7\u91ca\u653e\u7ec6\u80de\u5916\u56ca\u6ce1\uff08EVs\uff09\u6765\u4ecb\u5bfc\u3002EVs\u662f\u7eb3\u7c73\u7ea7\u819c\u5305\u88f9\u9897\u7c92\uff0c\u4e3b\u8981\u5305\u62ec\u5916\u6ccc\u4f53\u548c\u5fae\u56ca\u6ce1\uff0c\u5b83\u4eec\u4f5c\u4e3a\u86cb\u767d\u8d28\u3001\u8102\u8d28\u548c\u6838\u9178\u7b49\u751f\u7269\u6d3b\u6027\u5206\u5b50\u7684\u8f7d\u4f53\uff0c\u5b9e\u73b0\u7ec6\u80de\u95f4\u901a\u8baf\u3002MSCs\u6765\u6e90\u7684EVs\u80fd\u591f\u7a7f\u8fc7\u8840\u8111\u5c4f\u969c\uff0c\u53d1\u6325\u795e\u7ecf\u4fdd\u62a4\u3001\u4fc3\u518d\u751f\u548c\u514d\u75ab\u8c03\u8282\u4f5c\u7528\uff0c\u540c\u65f6\u907f\u514d\u4e86\u6d3b\u7ec6\u80de\u79fb\u690d\u5e26\u6765\u7684\u6f5c\u5728\u98ce\u9669\uff0c\u6210\u4e3a\u4e00\u79cd\u524d\u666f\u5e7f\u9614\u7684\u65e0\u7ec6\u80de\u6cbb\u7597\u7b56\u7565<\/p>\n<h2 data-nested=\"1\"><span class=\"ez-toc-section\" id=\"%E9%97%B4%E5%85%85%E8%B4%A8%E5%B9%B2%E7%BB%86%E8%83%9E%E5%BA%94%E7%94%A8%E6%B2%BB%E7%96%97%E7%A5%9E%E7%BB%8F%E7%B3%BB%E7%BB%9F%E7%96%BE%E7%97%85%E7%9A%84%E4%B8%B4%E5%BA%8A%E7%A0%94%E7%A9%B6\"><\/span><strong>\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u5e94\u7528\u6cbb\u7597\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u7684\u4e34\u5e8a\u7814\u7a76<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p data-nested=\"1\">\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09\u5728\u5352\u4e2d\u3001\u591a\u53d1\u6027\u786c\u5316\u75c7\u548c\u810a\u9ad3\u635f\u4f24\uff08SCI\uff09\u65e9\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u5df2\u521d\u6b65\u663e\u793a\u51fa\u5b89\u5168\u6027\u548c\u6f5c\u5728\u7684\u6cbb\u7597\u76ca\u5904\uff0c\u5305\u62ec\u51cf\u8f7b\u708e\u75c7\u548c\u6539\u5584\u529f\u80fd\u6062\u590d\u3002\u7136\u800c\uff0c\u8fd9\u4e9b\u53d1\u73b0\u4ecd\u5904\u4e8e\u63a2\u7d22\u9636\u6bb5\uff0c\u4e14\u5927\u591a\u6570\u8bc1\u636e\u4ecd\u5904\u4e8eI\/II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u9636\u6bb5\u3002<\/p>\n<\/section>\n<section data-role=\"list\" data-pm-slice=\"4 4 [&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;outer&quot;,&quot;label&quot;:&quot;edit by 135editor&quot;,&quot;data-pm-slice&quot;:&quot;0 0 []&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;paragraph&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;}]\">\n<p data-nested=\"1\">\u6b64\u5916\uff0c\u5927\u591a\u6570\u7814\u7a76\u7ed3\u679c\u4ecd\u5b58\u5728\u77db\u76fe\uff0c\u9700\u8981\u5f00\u5c55\u66f4\u591a\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\u3002\u4e3a\u4e86\u4fbf\u4e8e\u6bd4\u8f83\u4e0d\u540c\u7814\u7a76\u5e76\u7a81\u51fa\u4e34\u5e8a\u8bd5\u9a8c\u8bbe\u8ba1\u7684\u5f02\u8d28\u6027\uff0c\u4e0b\u8868\uff08\u88681\uff09\u603b\u7ed3\u4e86\u57fa\u4e8eMSCs\u7684\u5e72\u9884\u63aa\u65bd\u5728\u4e3b\u8981\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u4e2d\u7684\u5e94\u7528\u3002<\/p>\n<\/section>\n<section data-role=\"list\" data-pm-slice=\"4 4 [&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;outer&quot;,&quot;label&quot;:&quot;edit by 135editor&quot;,&quot;data-pm-slice&quot;:&quot;0 0 []&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;paragraph&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;}]\">\n<section><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-20741\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-02_115340_451.png\" alt=\"\" width=\"1654\" height=\"599\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-02_115340_451.png 1654w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-02_115340_451-300x109.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-02_115340_451-1024x371.png 1024w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-02_115340_451-768x278.png 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-02_115340_451-1536x556.png 1536w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-02_115340_451-18x7.png 18w\" sizes=\"(max-width: 1654px) 100vw, 1654px\" \/><\/section>\n<h3 data-nested=\"2\"><span class=\"ez-toc-section\" id=\"%E9%97%B4%E5%85%85%E8%B4%A8%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E4%B8%AD%E9%A3%8E%E7%9A%84%E4%B8%B4%E5%BA%8A%E6%A1%88%E4%BE%8B\"><\/span>\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6cbb\u7597\u4e2d\u98ce\u7684\u4e34\u5e8a\u6848\u4f8b<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p data-spm-anchor-id=\"5176.28103460.0.i4.3e3d7551oRde1y\">\u7f3a\u8840\u6027\u5352\u4e2d\u4ee5\u8111\u8840\u6d41\u7684\u6025\u6027\u4e2d\u65ad\u4e3a\u7279\u5f81\uff0c\u5bfc\u81f4\u795e\u7ecf\u5143\u6b7b\u4ea1\u3001\u795e\u7ecf\u708e\u75c7\u4ee5\u53ca\u795e\u7ecf\u8fde\u63a5\u7684\u4e27\u5931\u3002\u76ee\u524d\u7684\u6cbb\u7597\u9009\u62e9\u4ec5\u9650\u4e8e\u72ed\u7a84\u7684\u65f6\u95f4\u7a97\uff0c\u5c1a\u65e0\u9488\u5bf9\u6162\u6027\u5352\u4e2d\u7684\u6709\u6548\u795e\u7ecf\u4fee\u590d\u7597\u6cd5\u3002\u8fd9\u4e9b\u56e0\u7d20\u4f7f\u5352\u4e2d\u6210\u4e3a\u7ec6\u80de\u6cbb\u7597\u7684\u91cd\u8981\u9776\u70b9\uff0c\u65e8\u5728\u4fc3\u8fdb\u795e\u7ecf\u518d\u751f\u548c\u529f\u80fd\u6062\u590d\u3002<\/p>\n<p>\u8fd1\u5e74\u6765\uff0c\u8d8a\u6765\u8d8a\u591a\u4ee4\u4eba\u4fe1\u670d\u7684\u6570\u636e\u8868\u660e\uff0c\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09\u5728\u5352\u4e2d\u60a3\u8005\u4e2d\u5177\u6709\u826f\u597d\u7684\u5b89\u5168\u6027\u53ca\u6f5c\u5728\u7597\u6548\u3002<\/p>\n<p>Bang\u7b49\u4eba\u4e8e2005\u5e74\u5f00\u5c55\u7684\u4e00\u9879\u7814\u7a76\u7eb3\u5165\u4e8630\u4f8b\u6025\u6027\u5927\u8111\u4e2d\u52a8\u8109\u7f3a\u8840\u6027\u5352\u4e2d\u60a3\u8005\uff0c\u9759\u8109\u8f93\u6ce8\u81ea\u4f53\u9aa8\u9ad3\u6765\u6e90\u7684MSCs\uff081\u00d710\u2078\u4e2a\u7ec6\u80de\uff09\uff0c\u7ed3\u679c\u663e\u793a\u8be5\u7597\u6cd5\u5b89\u5168\uff0c\u5e76\u5728\u5df4\u6c0f\u6307\u6570\uff08Barthel Index\uff09\u4e0a\u8868\u73b0\u51fa\u4e0d\u540c\u7a0b\u5ea6\u7684\u6539\u5584\uff0c\u4e14\u6539\u826fRankin\u91cf\u8868\u8bc4\u5206\u5448\u4e0b\u964d\u8d8b\u52bf\uff1b\u8840\u6e05\u5b66\u548c\u795e\u7ecf\u5f71\u50cf\u5b66\u8bc4\u4f30\u5747\u672a\u53d1\u73b0\u4e0d\u826f\u53cd\u5e94\u3002<\/p>\n<p>\u5728\u66f4\u8fd1\u7684\u4e00\u9879\u7814\u7a76\u4e2d\uff0cLevy\u7b49\u4eba\uff082019\u5e74\uff09\u62a5\u9053\u4e86\u4e00\u9879I\/II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u7ed3\u679c\uff1a36\u4f8b\u6162\u6027\u5352\u4e2d\u60a3\u8005\uff08\u5e73\u5747\u75c5\u7a0b\u4e3a\u5352\u4e2d\u540e4.2\u5e74\uff09\u63a5\u53d7\u4e86\u4e00\u6b21\u6765\u81ea\u5065\u5eb7\u4f9b\u4f53\u7684\u540c\u79cd\u5f02\u4f53\u9aa8\u9ad3\u6765\u6e90MSCs\u8f93\u6ce8\uff08\u5242\u91cf\u6700\u9ad8\u8fbe150\u4e07\u4e2a\u7ec6\u80de\/\u516c\u65a4\u4f53\u91cd\uff09\u3002<\/p>\n<section>\n<div id=\"attachment_20739\" style=\"width: 1173px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-20739\" class=\"wp-image-20739 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-02_115944_401.png\" alt=\"\" width=\"1163\" height=\"376\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-02_115944_401.png 1163w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-02_115944_401-300x97.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-02_115944_401-1024x331.png 1024w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-02_115944_401-768x248.png 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-02_115944_401-18x6.png 18w\" sizes=\"(max-width: 1163px) 100vw, 1163px\" \/><p id=\"caption-attachment-20739\" class=\"wp-caption-text\">\u9759\u8109\u6ce8\u5c04\u5f02\u4f53\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6cbb\u7597\u6162\u6027\u5352\u4e2d\u7684\u5b89\u5168\u6027\u548c\u521d\u6b65\u7597\u6548\u7684I\/II\u671f\u7814\u7a76<\/p><\/div>\n<\/section>\n<\/section>\n<section data-role=\"list\" data-pm-slice=\"4 4 [&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;outer&quot;,&quot;label&quot;:&quot;edit by 135editor&quot;,&quot;data-pm-slice&quot;:&quot;0 0 []&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;paragraph&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;}]\">\u7814\u7a76\u672a\u8bb0\u5f55\u5230\u4e0e\u6cbb\u7597\u76f8\u5173\u7684\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\uff0c\u4e14\u5728\u4e3a\u671f12\u4e2a\u6708\u7684\u968f\u8bbf\u4e2d\uff0c\u60a3\u8005\u7684\u795e\u7ecf\u529f\u80fd\u7ed3\u5c40\uff08\u5305\u62ecNIHSS\u3001Barthel\u6307\u6570\u3001MMSE\u53ca\u6291\u90c1\u91cf\u8868\u8bc4\u5206\uff09\u5747\u663e\u793a\u51fa\u7edf\u8ba1\u5b66\u610f\u4e49\u4e0a\u7684\u663e\u8457\u6539\u5584\u3002\u8fd9\u4e24\u9879\u7814\u7a76\u5747\u8bc1\u5b9e\uff0c\u9759\u8109\u8f93\u6ce8MSCs\u6cbb\u7597\u5352\u4e2d\u662f\u5b89\u5168\u4e14\u8010\u53d7\u6027\u826f\u597d\u7684\uff0c\u652f\u6301\u5f00\u5c55\u66f4\u5927\u89c4\u6a21\u3001\u91c7\u7528\u4e25\u683c\u8bc4\u4f30\u6807\u51c6\u7684\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\u3002<\/p>\n<p 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src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-02_141508_069.png\" alt=\"\" width=\"872\" height=\"406\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-02_141508_069.png 872w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-02_141508_069-300x140.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-02_141508_069-768x358.png 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-02_141508_069-18x8.png 18w\" sizes=\"(max-width: 872px) 100vw, 872px\" \/><p id=\"caption-attachment-20733\" class=\"wp-caption-text\">\u9759\u8109\u6ce8\u5c04\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6cbb\u7597\u7f3a\u8840\u6027\u4e2d\u98ce\u7684\u7597\u6548\u548c\u5b89\u5168\u6027<\/p><\/div>\n<\/section>\n<p data-spm-anchor-id=\"5176.28103460.0.i3.3e3d7551oRde1y\">Bang\u7b49\u4eba\uff082005\uff09\u4e0eChung\u7b49\u4eba\uff082021\uff09\u7814\u7a76\u7ed3\u679c\u4e4b\u95f4\u7684\u5dee\u5f02\u53ef\u80fd\u6e90\u4e8e\u591a\u79cd\u56e0\u7d20\u3002\u8fd9\u4e9b\u7ed3\u679c\u7684\u5dee\u5f02\u53ef\u80fd\u6e90\u4e8e\u60a3\u8005\u75c5\u7a0b\uff08\u4e9a\u6025\u6027\u4e0e\u6162\u6027\uff09\u3001\u7ec6\u80de\u5242\u91cf\u3001\u57f9\u517b\u65b9\u6848\u53ca\u8bc4\u4f30\u6807\u51c6\u7684\u4e0d\u540c\uff0c\u5f3a\u8c03\u4e86\u672a\u6765\u7814\u7a76\u9700\u8981\u6807\u51c6\u5316\u8bbe\u8ba1\u548c\u5b8c\u5584\u7684\u60a3\u8005\u5206\u5c42\u3002<\/p>\n<h3 data-nested=\"2\"><span class=\"ez-toc-section\" id=\"%E9%97%B4%E5%85%85%E8%B4%A8%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E5%A4%9A%E5%8F%91%E6%80%A7%E7%A1%AC%E5%8C%96%E7%97%87%E7%9A%84%E4%B8%B4%E5%BA%8A%E6%A1%88%E4%BE%8B\"><\/span>\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6cbb\u7597\u591a\u53d1\u6027\u786c\u5316\u75c7\u7684\u4e34\u5e8a\u6848\u4f8b<span 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class=\"\">\u8131\u9ad3\u9798\u75be\u75c5<\/span>\uff0c\u4e3b\u8981\u7d2f\u53ca\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\uff0c\u7531\u81ea\u8eab\u514d\u75ab\u673a\u5236\u548c\u795e\u7ecf\u9000\u884c\u6027\u53d8\u9a71\u52a8\u3002\u5c3d\u7ba1\u5df2\u6709\u514d\u75ab\u8c03\u8282\u836f\u7269\uff0c\u4f46\u8fdb\u5c55\u6027\u591a\u53d1\u6027\u786c\u5316\u75c7\u4ecd\u96be\u4ee5\u6cbb\u6108\u3002\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09\u7684\u514d\u75ab\u8c03\u8282\u548c\u795e\u7ecf\u4fdd\u62a4\u7279\u6027\u4f7f\u5176\u6210\u4e3a\u5ef6\u7f13\u75be\u75c5\u8fdb\u5c55\u548c\u4fee\u590d\u795e\u7ecf\u635f\u4f24\u7684\u6f5c\u5728\u5019\u9009\u8005\u3002<\/p>\n<p>2024\u5e74\uff0c\u4e00\u9879\u9488\u5bf9\u8fdb\u884c\u6027\u591a\u53d1\u6027\u786c\u5316\u75c7\u60a3\u8005\u7684\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u8bc1\u5b9e\u4e86\u4f7f\u7528\u9aa8\u9ad3\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSC\uff09\u6765\u6e90\u7684\u795e\u7ecf\u7956\u7ec6\u80de\uff08NPs\uff09\u8fdb\u884c\u6cbb\u7597\u7684\u6709\u6548\u6027\u3002<\/p>\n<section>\n<div id=\"attachment_20738\" style=\"width: 769px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-20738\" class=\"wp-image-20738 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-02_135348_743.png\" alt=\"\" width=\"759\" height=\"412\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-02_135348_743.png 759w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-02_135348_743-300x163.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-02_135348_743-18x10.png 18w\" sizes=\"(max-width: 759px) 100vw, 759px\" \/><p id=\"caption-attachment-20738\" class=\"wp-caption-text\">\u9798\u5185\u6ce8\u5c04\u95f4\u5145\u8d28\u5e72\u7ec6\u80de-\u795e\u7ecf\u7956\u7ec6\u80de\u7597\u6cd5\u6cbb\u7597\u8fdb\u5c55\u578b\u591a\u53d1\u6027\u786c\u5316\u75c7\u7684\u7597\u6548\uff1a\u4e00\u9879 II 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[]&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;paragraph&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;}]\">\u5728\u7814\u7a76\u7684\u7b2c\u4e00\u5e74\uff0c\u5206\u914d\u81f3MSC-NP\u7ec4\u7684\u53d7\u8bd5\u8005\u63a5\u53d7\u4e86\u516d\u6b21\u9798\u5185\u6ce8\u5c04\uff0c\u6bcf\u6b21\u6ce8\u5c04\u5242\u91cf\u9ad8\u8fbe1\u00d710\u2077\u4e2a\u81ea\u4f53MSC-NPs\uff0c\u6bcf\u6b21\u6ce8\u5c04\u95f4\u9694\u4e24\u4e2a\u6708\uff08\u7b2c1\u81f36\u6b21\u6cbb\u7597\uff09\u3002\u9798\u5185\u6ce8\u5c04MSC-NP\u53ef\u6539\u5584\u8180\u80f1\u529f\u80fd\uff0c\u5e76\u964d\u4f4e\u8111\u90e8MRI\u663e\u793a\u7684\u7070\u8d28\u840e\u7f29\u7387\u3002\u751f\u7269\u6807\u5fd7\u7269\u5206\u6790\u663e\u793a\uff0c\u6cbb\u7597\u540e\u8111\u810a\u6db2\u4e2dMMP9\u6c34\u5e73\u5347\u9ad8\uff0cCCL2\u6c34\u5e73\u964d\u4f4e\u3002\u5c3d\u7ba1\u8fd9\u4e9b\u53d1\u73b0\u4ee4\u4eba\u9f13\u821e\uff0c\u4f46\u4ecd\u5c5e\u521d\u6b65\u7ed3\u679c\uff0c\u9700\u8981\u8fdb\u4e00\u6b65\u7814\u7a76\u6765\u8bc1\u5b9e\u8fd9\u4e9b\u6548\u5e94\u7684\u53ef\u91cd\u590d\u6027\u548c\u957f\u671f\u4e34\u5e8a\u610f\u4e49\u3002<\/p>\n<h3><span class=\"ez-toc-section\" id=\"%E9%97%B4%E5%85%85%E8%B4%A8%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E8%84%8A%E9%AB%93%E6%8D%9F%E4%BC%A4%E7%9A%84%E4%B8%B4%E5%BA%8A%E6%A1%88%E4%BE%8B\"><\/span>\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6cbb\u7597\u810a\u9ad3\u635f\u4f24\u7684\u4e34\u5e8a\u6848\u4f8b<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u810a\u9ad3\u635f\u4f24\uff08SCI\uff09\u56e0\u5e7f\u6cdb\u7684\u795e\u7ecf\u5143\u6b7b\u4ea1\u3001\u80f6\u8d28\u7622\u75d5\u5f62\u6210\u53ca\u6162\u6027\u708e\u75c7\uff0c\u5bfc\u81f4\u611f\u89c9\u548c\u8fd0\u52a8\u529f\u80fd\u4e0d\u53ef\u9006\u7684\u4e27\u5931\u3002\u76ee\u524d\u7684\u6cbb\u7597\u4e3b\u8981\u4fa7\u91cd\u4e8e\u75c5\u60c5\u7a33\u5b9a\u548c\u5eb7\u590d\u8bad\u7ec3\uff0c\u518d\u751f\u4fee\u590d\u6548\u679c\u5341\u5206\u6709\u9650\u3002\u57fa\u4e8e\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09\u7684\u7597\u6cd5\u5728\u795e\u7ecf\u4fdd\u62a4\u3001\u8f74\u7a81\u518d\u751f\u4ee5\u53ca\u8c03\u63a7\u635f\u4f24\u540e\u5fae\u73af\u5883\u65b9\u9762\u5c55\u73b0\u51fa\u6f5c\u5728\u4ef7\u503c\u3002<\/p>\n<p>Mac\u00eado\u7b49\u4eba\uff082024\u5e74\uff09\u5f00\u5c55\u7684\u4e00\u9879\u7814\u7a76\u4e2d\uff0c\u5bf9\u6162\u6027\u9888\u6bb5\u810a\u9ad3\u635f\u4f24\u60a3\u8005\u5b9e\u65bd\u4e86\u81ea\u4f53\u9aa8\u9ad3\u6765\u6e90MSCs\u79fb\u690d\u3002<\/p>\n<section>\n<div id=\"attachment_20737\" style=\"width: 932px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-20737\" class=\"wp-image-20737 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-02_135622_312.png\" alt=\"\" width=\"922\" height=\"500\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-02_135622_312.png 922w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-02_135622_312-300x163.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-02_135622_312-768x416.png 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-02_135622_312-18x10.png 18w\" sizes=\"(max-width: 922px) 100vw, 922px\" \/><p id=\"caption-attachment-20737\" class=\"wp-caption-text\">\u81ea\u4f53\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u79fb\u690d\u6cbb\u7597\u5b8c\u5168\u6027\u9888\u9ad3\u635f\u4f24\uff1a\u4e00\u9879\u521d\u6b65\u7814\u7a76<\/p><\/div>\n<\/section>\n<p>\u60a3\u8005\u63a5\u53d7\u4e86\u4e24\u6b21MSCs\u7ed9\u836f\uff1a\u9996\u6b21\u4e3a\u534a\u690e\u677f\u5207\u9664\u672f\u540e\u884c\u810a\u9ad3\u5185\u6ce8\u5c04\uff0c\u4e09\u4e2a\u6708\u540e\u8fdb\u884c\u9798\u5185\u6ce8\u5c04\u3002\u8be5\u7597\u6cd5\u88ab\u8bc1\u5b9e\u5177\u6709\u826f\u597d\u7684\u5b89\u5168\u6027\uff0cMRI\u68c0\u67e5\u672a\u53d1\u73b0\u65b0\u7684\u80f6\u8d28\u589e\u751f\u7076\u6216\u80bf\u7624\u751f\u957f\u8ff9\u8c61\u3002\u7136\u800c\uff0c\u529f\u80fd\u8bc4\u4f30\u5e76\u672a\u663e\u793aMSCs\u6cbb\u7597\u540e\u60a3\u8005\u7ed3\u5c40\u6709\u663e\u8457\u6539\u5584\u3002\u7531\u4e8e\u7814\u7a76\u7f3a\u4e4f\u968f\u673a\u5316\u8bbe\u8ba1\u4e14\u6837\u672c\u91cf\u4ec5\u4e3a6\u4f8b\uff0c\u5c1a\u65e0\u6cd5\u5f97\u51fa\u660e\u786e\u7ed3\u8bba\u3002<\/p>\n<p>\u540c\u5e74\uff0c\u5728\u53e6\u4e00\u9879\u8fd1\u671f\u7684I\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u7814\u7a76\u8005\u5bf910\u4f8b\u810a\u9ad3\u635f\u4f24\u60a3\u8005\u8fdb\u884c\u4e86\u81ea\u4f53\u8102\u80aa\u6765\u6e90MSCs\u7684\u9798\u5185\u8f93\u6ce8\u3002\u7ed3\u679c\u518d\u6b21\u8bc1\u5b9e\u4e86\u8be5\u6cbb\u7597\u7b56\u7565\u7684\u5b89\u5168\u6027\uff0c\u5176\u4e2d7\u4f8b\u60a3\u8005\u7684\u7f8e\u56fd\u810a\u9ad3\u635f\u4f24\u534f\u4f1a\u635f\u4f24\u91cf\u8868\uff08AIS\uff09\u5206\u7ea7\u6709\u6240\u6539\u5584\u3002<\/p>\n<section>\n<div id=\"attachment_20736\" style=\"width: 772px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-20736\" class=\"wp-image-20736 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-02_135800_712.png\" alt=\"\" width=\"762\" height=\"418\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-02_135800_712.png 762w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-02_135800_712-300x165.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-02_135800_712-18x10.png 18w\" sizes=\"(max-width: 762px) 100vw, 762px\" \/><p id=\"caption-attachment-20736\" class=\"wp-caption-text\">\u9798\u5185\u6ce8\u5c04\u8102\u80aa\u6765\u6e90\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6cbb\u7597\u521b\u4f24\u6027\u810a\u9ad3\u635f\u4f24\uff1aI\u671f\u8bd5\u9a8c<\/p><\/div>\n<\/section>\n<\/section>\n<section data-role=\"list\" data-pm-slice=\"4 4 [&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;outer&quot;,&quot;label&quot;:&quot;edit by 135editor&quot;,&quot;data-pm-slice&quot;:&quot;0 0 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data-spm-anchor-id=\"5176.28103460.0.i0.13726308wh9Hxu\">\u7efc\u4e0a\u6240\u8ff0\uff0c\u73b0\u6709\u6570\u636e\u8868\u660eMSCs\u6cbb\u7597\u5728\u810a\u9ad3\u635f\u4f24\u4e2d\u5177\u6709\u5b89\u5168\u6027\u548c\u53ef\u884c\u6027\uff0c\u4f46\u5c1a\u4e0d\u8db3\u4ee5\u8bc1\u660e\u5176\u4e34\u5e8a\u6709\u6548\u6027\u3002<\/p>\n<h3><span class=\"ez-toc-section\" id=\"%E9%97%B4%E5%85%85%E8%B4%A8%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E9%98%BF%E5%B0%94%E8%8C%A8%E6%B5%B7%E9%BB%98%E7%97%85%E7%9A%84%E4%B8%B4%E5%BA%8A%E6%A1%88%E4%BE%8B\"><\/span>\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6cbb\u7597\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u4e34\u5e8a\u6848\u4f8b<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p data-spm-anchor-id=\"5176.28103460.0.i2.13726308FGdtOX\">\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\uff08AD\uff09\u662f\u4e00\u79cd\u8fdb\u884c\u6027\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\uff0c\u5176\u7279\u5f81\u5305\u62ec\u03b2-\u6dc0\u7c89\u6837\u86cb\u767d\uff08amyloid-\u03b2\uff09\u6c89\u79ef\u3001tau\u86cb\u767d\u75c5\u7406\u3001\u7a81\u89e6\u529f\u80fd\u969c\u788d\u4ee5\u53ca\u795e\u7ecf\u5143\u4e22\u5931\u3002\u76ee\u524d\u7684\u836f\u7269\u6cbb\u7597\u4ec5\u80fd\u7f13\u89e3\u75c7\u72b6\uff0c\u65e0\u6cd5\u6539\u53d8\u75be\u75c5\u7684\u8fdb\u5c55\u3002\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09\u53ca\u5176\u884d\u751f\u7269\u4ee3\u8868\u4e86\u4e00\u79cd\u65b0\u7b56\u7565\uff0c\u65e8\u5728\u8c03\u63a7\u795e\u7ecf\u708e\u75c7\u5e76\u63d0\u4f9b\u795e\u7ecf\u8425\u517b\u652f\u6301\uff0c\u4ece\u800c\u5e72\u9884\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u75c5\u7406\u8fc7\u7a0b\u3002<\/p>\n<p data-spm-anchor-id=\"5176.28103460.0.i1.13726308FGdtOX\">Kim\u7b49\u4eba\uff082021\u5e74\uff09\u6210\u529f\u5f00\u5c55\u4e86\u4e00\u9879I\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u901a\u8fc7\u8111\u5ba4\u6ce8\u5c04\u4eba\u8110\u5e26\u8840\u6765\u6e90\u7684\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08hUCB-MSCs\uff09\u6cbb\u7597\u8f7b\u81f3\u4e2d\u5ea6\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u60a3\u8005\u3002\u7814\u7a76\u5171\u7eb3\u51659\u4f8b\u60a3\u8005\uff0c\u5747\u690d\u5165Ommaya\u50a8\u6db2\u56ca\uff0c\u5e76\u901a\u8fc7\u8be5\u88c5\u7f6e\u5206\u4e09\u6b21\u7ed9\u4e88hUCB-MSCs\uff0c\u6bcf\u6b21\u95f4\u96944\u5468\uff1a\u5176\u4e2d3\u4f8b\u63a5\u53d7\u4f4e\u5242\u91cf\uff081.0\u00d710\u2077\u4e2a\u7ec6\u80de\/2mL\uff09\uff0c6\u4f8b\u63a5\u53d7\u9ad8\u5242\u91cf\uff083.0\u00d710\u2077\u4e2a\u7ec6\u80de\/2mL\uff09\u3002<\/p>\n<section>\n<div id=\"attachment_20735\" style=\"width: 776px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-20735\" class=\"wp-image-20735 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-02_135957_207.png\" alt=\"\" width=\"766\" height=\"439\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-02_135957_207.png 766w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-02_135957_207-300x172.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-02_135957_207-18x10.png 18w\" sizes=\"(max-width: 766px) 100vw, 766px\" \/><p id=\"caption-attachment-20735\" class=\"wp-caption-text\">\u5411\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u75f4\u5446\u60a3\u8005\u8111\u5ba4\u5185\u6ce8\u5c04\u4eba\u8110\u5e26\u8840\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff1a\u4e00\u9879 I \u671f\u4e34\u5e8a\u8bd5\u9a8c<\/p><\/div>\n<\/section>\n<\/section>\n<section data-role=\"list\" data-pm-slice=\"4 4 [&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;outer&quot;,&quot;label&quot;:&quot;edit by 135editor&quot;,&quot;data-pm-slice&quot;:&quot;0 0 []&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;paragraph&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;}]\">\n<p data-spm-anchor-id=\"5176.28103460.0.i1.13726308FGdtOX\">\u7ed9\u836f\u540e\u7acb\u5373\u51fa\u73b0\u77ed\u6682\u6027\u53d1\u70ed\uff0c\u4f46\u5747\u57281\u20132\u5929\u5185\u81ea\u884c\u6d88\u9000\u3002\u8fd9\u79cd\u53cd\u5e94\u53ef\u80fd\u53cd\u6620\u4e86\u673a\u4f53\u5bf9hUCB-MSCs\u672c\u8eab\u6216\u5bf9\u57f9\u517b\u6db2\u53ca\u8840\u6e05\u6210\u5206\u7684\u514d\u75ab\u5e94\u7b54\u3002\u6bcf\u6b21\u6ce8\u5c04\u540e\u4e00\u5929\uff0c\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u76f8\u5173\u751f\u7269\u6807\u5fd7\u7269\uff08\u603btau\u86cb\u767d\u3001\u78f7\u9178\u5316tau\u86cb\u767d\u548cA\u03b242\uff09\u6c34\u5e73\u5747\u6709\u6240\u4e0b\u964d\uff0c\u4f46\u5728\u56db\u5468\u5185\u6062\u590d\u81f3\u57fa\u7ebf\u6c34\u5e73\u3002\u90e8\u5206\u60a3\u8005\u7684\u6dc0\u7c89\u6837\u86cb\u767dPET\u6210\u50cf\u663e\u793a\u8f7b\u5fae\u6539\u5584\uff1b\u7136\u800c\uff0c\u7531\u4e8e\u7f3a\u4e4f\u5bf9\u7167\u7ec4\uff0c\u5c1a\u96be\u4ee5\u5c31\u7597\u6548\u5f97\u51fa\u660e\u786e\u7ed3\u8bba\u3002<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%E9%97%B4%E5%85%85%E8%B4%A8%E5%B9%B2%E7%BB%86%E8%83%9E%E6%9D%A5%E6%BA%90%E5%A4%96%E6%B3%8C%E4%BD%93%E6%B2%BB%E7%96%97%E7%A5%9E%E7%BB%8F%E7%B3%BB%E7%BB%9F%E7%96%BE%E7%97%85%E7%9A%84%E4%B8%B4%E5%BA%8A%E7%A0%94%E7%A9%B6\"><\/span><strong>\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6765\u6e90\u5916\u6ccc\u4f53\u6cbb\u7597\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u7684\u4e34\u5e8a\u7814\u7a76<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p data-spm-anchor-id=\"5176.28103460.0.i10.13726308wh9Hxu\">\u6700\u65e9\u65e8\u5728\u8bc4\u4f30\u9f3b\u5185\u7ed9\u4e88MSC\u6765\u6e90\u5916\u6ccc\u4f53\u6cbb\u7597\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u7684\u4e34\u5e8a\u7814\u7a76\u4e4b\u4e00\uff0c\u662fXie\u7b49\u4eba\uff082023\u5e74\uff09\u5f00\u5c55\u7684\u4e00\u9879\u5f00\u653e\u6807\u7b7eI\/II\u671f\u8bd5\u9a8c\u3002<\/p>\n<section>\n<div id=\"attachment_20734\" style=\"width: 774px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-20734\" class=\"wp-image-20734 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-02_140846_142.png\" alt=\"\" width=\"764\" height=\"456\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-02_140846_142.png 764w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-02_140846_142-300x179.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-02_140846_142-18x12.png 18w\" sizes=\"(max-width: 764px) 100vw, 764px\" \/><p id=\"caption-attachment-20734\" class=\"wp-caption-text\">\u540c\u79cd\u5f02\u4f53\u4eba\u8102\u80aa\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6765\u6e90\u5916\u6ccc\u4f53\u6cbb\u7597\u8f7b\u5ea6\u81f3\u4e2d\u5ea6\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u60a3\u8005\u7684\u4e34\u5e8a\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\uff1a\u4e00\u9879I\/II\u671f\u4e34\u5e8a\u8bd5\u9a8c<\/p><\/div>\n<\/section>\n<p data-spm-anchor-id=\"5176.28103460.0.i10.13726308wh9Hxu\">\u4f5c\u8005\u5728\u8f7b\u81f3\u4e2d\u5ea6\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u60a3\u8005\u4e2d\u6d4b\u8bd5\u4e86\u6765\u6e90\u4e8e\u540c\u79cd\u5f02\u4f53\u8102\u80aa\u7ec4\u7ec7MSC\u7684\u5916\u6ccc\u4f53\uff08ahaMSC-Exos\uff09\u30029\u540d\u53d7\u8bd5\u8005\u572812\u5468\u5185\u6bcf\u5468\u63a5\u53d7\u4e24\u6b21\u4e0d\u540c\u5242\u91cf\uff082\u00d710\u2078\u30014\u00d710\u2078\u548c8\u00d710\u2078\u4e2a\u9897\u7c92\uff09\u7684\u6cbb\u7597\uff0c\u5e76\u968f\u8bbf\u81f3\u7b2c48\u5468\u3002<\/p>\n<p 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data-spm-anchor-id=\"5176.28103460.0.i9.13726308wh9Hxu\">\u5c3d\u7ba1\u6709\u8fd9\u4e9b\u79ef\u6781\u548c\u4ee4\u4eba\u9f13\u821e\u7684\u53d1\u73b0\uff0c\u4f46\u5173\u4e8e\u8fd9\u79cd\u6cbb\u7597\u65b9\u6cd5\u7684\u4e34\u5e8a\u7597\u6548\u4ecd\u5b58\u5728\u8bb8\u591a\u95ee\u9898\uff0c\u8fd9\u4e9b\u95ee\u9898\u5fc5\u987b\u5728\u672a\u6765\u7684\u7814\u7a76\u4e2d\u52a0\u4ee5\u89e3\u51b3\u3002<\/p>\n<h2 data-nested=\"1\"><span class=\"ez-toc-section\" id=\"%E9%97%B4%E5%85%85%E8%B4%A8%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E7%A5%9E%E7%BB%8F%E7%B3%BB%E7%BB%9F%E7%96%BE%E7%97%85%E7%9A%84%E6%97%A7%E9%97%AE%E9%A2%98%E4%B8%8E%E6%8C%91%E6%88%98\"><\/span><strong>\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6cbb\u7597\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u7684\u65e7\u95ee\u9898\u4e0e\u6311\u6218<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p data-spm-anchor-id=\"5176.28103460.0.i1.13726308FGdtOX\">\u5c3d\u7ba1MSC\u5e94\u7528\u6280\u672f\u5f97\u5230\u4e86\u79ef\u6781\u53d1\u5c55\uff0c\u5e76\u4e14\u5728\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u7684\u4e34\u5e8a\u524d\u7814\u7a76\u4e2d\u53d6\u5f97\u4e86\u4ee4\u4eba\u9f13\u821e\u7684\u7ed3\u679c\uff0c\u4f46\u4ecd\u5b58\u5728\u4e00\u4e9b\u5173\u952e\u95ee\u9898\u9650\u5236\u4e86\u5176\u4e34\u5e8a\u5e94\u7528\u3002<\/p>\n<p>\uff081\uff09\u7ec6\u80de\u9012\u9001\u4e0e\u5f02\u8d28\u6027\u6311\u6218\uff1a\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6cbb\u7597\u9762\u4e34\u7684\u9996\u8981\u96be\u9898\u662f\u7ec6\u80de\u5728\u4f53\u5185\u7684\u4f4e\u6548\u8fc1\u79fb\u4e0e\u690d\u5165\u3002\u9759\u8109\u8f93\u6ce8\u540e\uff0c\u4ec5\u6709\u6781\u5c11\u91cf\u7ec6\u80de\u80fd\u5230\u8fbe\u9776\u7ec4\u7ec7\uff0c\u8fd9\u4e3b\u8981\u6e90\u4e8e\u4f53\u5916\u6269\u589e\u7684MSCs\u5f52\u5de2\u53d7\u4f53\u8868\u8fbe\u4e0d\u8db3\u3002\u6b64\u5916\uff0cMSCs\u7684\u8d28\u91cf\u548c\u529f\u80fd\u5b58\u5728\u663e\u8457\u5f02\u8d28\u6027\uff0c\u53d7\u4f9b\u4f53\u5e74\u9f84\u3001\u7ec4\u7ec7\u6765\u6e90\u548c\u57f9\u517b\u6761\u4ef6\u7b49\u56e0\u7d20\u5f71\u54cd\uff0c\u76f4\u63a5\u5bfc\u81f4\u5176\u589e\u6b96\u6f5c\u80fd\u3001\u5206\u5316\u80fd\u529b\u53ca\u6cbb\u7597\u6548\u679c\u7684\u4e0d\u7a33\u5b9a\uff0c\u4e3a\u6807\u51c6\u5316\u5e94\u7528\u5e26\u6765\u969c\u788d\u3002<\/p>\n<p>\uff082\uff09\u4f5c\u7528\u673a\u5236\u5c1a\u672a\u5b8c\u5168\u9610\u660e\uff1a\u5c3d\u7ba1\u7814\u7a76\u663e\u793aMSCs\u5728\u795e\u7ecf\u75be\u75c5\u4e2d\u80fd\u53d1\u6325\u79ef\u6781\u4f5c\u7528\uff0c\u4f46\u5176\u786e\u5207\u4f5c\u7528\u673a\u5236\u4ecd\u4e0d\u660e\u786e\u3002\u73b0\u6709\u8bc1\u636e\u8868\u660e\uff0c\u5176\u4e3b\u8981\u7597\u6548\u5e76\u975e\u901a\u8fc7\u76f4\u63a5\u5206\u5316\u4e3a\u795e\u7ecf\u7ec6\u80de\u6765\u5b9e\u73b0\uff0c\u800c\u662f\u4f9d\u8d56\u4e8e\u65c1\u5206\u6ccc\u6548\u5e94\uff0c\u5373\u901a\u8fc7\u5206\u6ccc\u751f\u957f\u56e0\u5b50\u3001\u7ec6\u80de\u56e0\u5b50\u548c\u5916\u6ccc\u4f53\u7b49\u7269\u8d28\u6765\u8c03\u8282\u514d\u75ab\u3001\u6291\u5236\u708e\u75c7\u53ca\u652f\u6301\u5fae\u73af\u5883\u4fee\u590d\u3002\u8fd9\u79cd\u673a\u5236\u4e0a\u7684\u4e0d\u6e05\u6670\uff0c\u5236\u7ea6\u4e86\u9488\u5bf9\u6027\u7684\u7597\u6548\u4f18\u5316\u548c\u7cbe\u51c6\u6cbb\u7597\u65b9\u6848\u7684\u8bbe\u8ba1\u3002<\/p>\n<p>\uff083\uff09\u5b89\u5168\u6027\u4e0e\u81f4\u764c\u98ce\u9669\uff1aMSCs\u79fb\u690d\u53ef\u80fd\u5e26\u6765\u6f5c\u5728\u7684\u5b89\u5168\u9690\u60a3\uff0c\u5176\u4e2d\u81f4\u764c\u98ce\u9669\u5c24\u4e3a\u5f15\u4eba\u5173\u6ce8\u3002\u7814\u7a76\u63d0\u793a\uff0c\u5728\u7279\u5b9a\u75c5\u7406\u5fae\u73af\u5883\uff08\u5982\u80bf\u7624\u5171\u5b58\uff09\u4e0b\uff0cMSCs\u53ef\u80fd\u88ab\u8bf1\u5bfc\u53d1\u751f\u6076\u6027\u8f6c\u5316\uff0c\u6216\u56e0\u5176\u81ea\u8eab\u643a\u5e26\u67d3\u8272\u4f53\u5f02\u5e38\u800c\u76f4\u63a5\u4fc3\u6210\u80bf\u7624\u5f62\u6210\u3002\u8fd9\u51f8\u663e\u4e86\u5bf9\u4f9b\u4f53\u7ec6\u80de\u8fdb\u884c\u4e25\u683c\u7b5b\u9009\u3001\u8d28\u91cf\u63a7\u5236\u548c\u957f\u671f\u5b89\u5168\u6027\u8bc4\u4f30\u7684\u5fc5\u8981\u6027\uff0c\u5c24\u5176\u662f\u5728\u60a3\u6709\u6216\u6709\u80bf\u7624\u75c5\u53f2\u7684\u60a3\u8005\u7fa4\u4f53\u4e2d\u9700\u5236\u5b9a\u660e\u786e\u7684\u6392\u9664\u6807\u51c6\u3002<\/p>\n<p 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https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/biologics-05-00037-g001-300x79.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/biologics-05-00037-g001-1024x269.png 1024w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/biologics-05-00037-g001-768x202.png 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/biologics-05-00037-g001-1536x404.png 1536w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/biologics-05-00037-g001-2048x538.png 2048w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/biologics-05-00037-g001-18x5.png 18w\" sizes=\"(max-width: 3032px) 100vw, 3032px\" \/><p id=\"caption-attachment-20740\" class=\"wp-caption-text\">\u56fe1\uff1a\u57fa\u4e8e\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSC\uff09\u7684\u795e\u7ecf\u518d\u751f\u7597\u6cd5\u4ece\u201c\u65e7\u95ee\u9898\u201d\u5230\u201c\u65b0\u673a\u9047\u201d\u7684\u8f6c\u53d8\u793a\u610f\u56fe\u3002\u8be5\u56fe\u5c55\u793a\u4e86\u5f53\u524d\u751f\u7269\u6280\u672f\u7b56\u7565\uff08\u4e2d\uff09\u5982\u4f55\u89e3\u51b3MSC\u5e94\u7528\u7684\u4e3b\u8981\u5386\u53f2\u5c40\u9650\u6027\uff08\u5de6\u56fe\uff09 \uff0c\u4ece\u800c\u5b9e\u73b0\u66f4\u5b89\u5168\u3001\u66f4\u6807\u51c6\u5316\u4e14\u66f4\u5177\u4e34\u5e8a\u8f6c\u5316\u6027\u7684MSC\u7597\u6cd5\uff08\u53f3\u56fe\uff09\u3002<\/p><\/div>\n<\/section>\n<h2 data-nested=\"1\"><span class=\"ez-toc-section\" id=\"%E9%97%B4%E5%85%85%E8%B4%A8%E5%B9%B2%E7%BB%86%E8%83%9E%E5%8F%8A%E5%85%B6%E8%A1%8D%E7%94%9F%E7%89%A9%E6%B2%BB%E7%96%97%E7%A5%9E%E7%BB%8F%E7%B3%BB%E7%BB%9F%E7%96%BE%E7%97%85%E7%9A%84%E6%96%B0%E7%9A%84%E5%8F%AF%E8%83%BD%E6%80%A7%E5%92%8C%E6%96%B9%E6%B3%95\"><\/span><strong>\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u53ca\u5176\u884d\u751f\u7269\u6cbb\u7597\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u7684\u65b0\u7684\u53ef\u80fd\u6027\u548c\u65b9\u6cd5<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>\u5c3d\u7ba1\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u7684\u5e94\u7528\u4ecd\u5b58\u5728\u4e00\u4e9b\u95ee\u9898\u548c\u5c40\u9650\u6027\uff0c\u4f46\u751f\u7269\u6280\u672f\u7684\u53d1\u5c55\u5f00\u8f9f\u4e86\u65b0\u7684\u524d\u666f\uff1a<\/p>\n<p><strong>\u6cbb\u7597\u8f7d\u4f53\u7684\u9769\u65b0\uff1a\u8f6c\u5411\u65e0\u7ec6\u80de\u7597\u6cd5\uff1a<\/strong>\u7814\u7a76\u91cd\u70b9\u6b63\u4ece\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u672c\u8eab\u8f6c\u5411\u5176\u5206\u6ccc\u7684\u884d\u751f\u7269\uff0c\u7279\u522b\u662f\u5916\u6ccc\u4f53\u7b49\u7ec6\u80de\u5916\u56ca\u6ce1\u3002\u8fd9\u4e9b\u7eb3\u7c73\u7ea7\u9897\u7c92\u7ee7\u627f\u4e86\u5e72\u7ec6\u80de\u7684\u65c1\u5206\u6ccc\u529f\u80fd\uff0c\u80fd<a class=\"normal_text_link mp_article_text_link\" href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzkwOTEzMDY0Nw==&amp;mid=2247516159&amp;idx=1&amp;sn=1fdcc8fb68737e463eb335627f652c1d&amp;scene=21#wechat_redirect\" target=\"_blank\" rel=\"noopener nofollow\" data-itemshowtype=\"0\" data-linktype=\"2\">\u6709\u6548\u7a7f\u8fc7\u8840\u8111\u5c4f\u969c<\/a>\uff0c\u5177\u6709\u4f4e\u514d\u75ab\u539f\u6027\u3001\u6613\u4e8e\u6807\u51c6\u5316\u5927\u89c4\u6a21\u751f\u4ea7\u7b49\u4f18\u52bf\u3002\u5728\u591a\u79cd\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u6a21\u578b\u4e2d\uff0c\u5b83\u4eec\u5df2\u88ab\u8bc1\u5b9e\u80fd\u51cf\u8f7b\u795e\u7ecf\u708e\u75c7\u3001\u4fc3\u8fdb\u7ec4\u7ec7\u4fee\u590d\u4e0e\u529f\u80fd\u6062\u590d\uff0c\u4e3a\u5f00\u53d1\u66f4\u5b89\u5168\u3001\u53ef\u63a7\u7684\u65e0\u7ec6\u80de\u6cbb\u7597\u7b56\u7565\u5f00\u8f9f\u4e86\u65b0\u9053\u8def\u3002<\/p>\n<p><strong>\u529f\u80fd\u5f3a\u5316\u7b56\u7565\uff1a\u57fa\u56e0\u5de5\u7a0b\u6539\u9020\uff1a<\/strong>\u901a\u8fc7\u57fa\u56e0\u5de5\u7a0b\u6280\u672f\uff08\u5982CRISPR\/Cas9\u3001\u75c5\u6bd2\u8f7d\u4f53\uff09\u5bf9\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u8fdb\u884c\u6539\u9020\uff0c\u80fd\u663e\u8457\u589e\u5f3a\u5176\u6cbb\u7597\u6f5c\u529b\u3002\u6539\u9020\u76ee\u6807\u5305\u62ec\u4e0a\u8c03\u795e\u7ecf\u8425\u517b\u56e0\u5b50\uff08\u5982BDNF\u3001GDNF\uff09\u6216\u6297\u708e\u56e0\u5b50\uff08\u5982IL-10\uff09\u7684\u8868\u8fbe\u4ee5\u589e\u5f3a\u795e\u7ecf\u4fdd\u62a4\uff0c\u6216\u4fee\u9970\u8d8b\u5316\u53d7\u4f53\uff08\u5982CXCR4\uff09\u4ee5\u6539\u5584\u5176\u5411\u75c5\u7076\u90e8\u4f4d\u7684\u5f52\u5de2\u80fd\u529b\u3002<\/p>\n<p>\u66f4\u6709\u524d\u666f\u7684\u662f\u5f00\u53d1\u667a\u80fd\u8c03\u63a7\u578b\u7ec6\u80de\uff0c\u4f7f\u5176\u6cbb\u7597\u6027\u57fa\u56e0\u7684\u8868\u8fbe\u80fd\u54cd\u5e94\u635f\u4f24\u5fae\u73af\u5883\uff08\u5982\u7f3a\u6c27\u3001\u708e\u75c7\uff09\u7684\u7279\u5f02\u6027\u4fe1\u53f7\uff0c\u4ece\u800c\u5b9e\u73b0\u7cbe\u51c6\u3001\u9ad8\u6548\u7684\u6cbb\u7597\u3002<\/p>\n<p><strong>\u57f9\u517b\u4f53\u7cfb\u7684\u5347\u7ea7\uff1a3D\u6a21\u578b\u4e0e\u751f\u7269\u5236\u9020\uff1a<\/strong>\u4ece\u4f20\u7edf\u4e8c\u7ef4\u57f9\u517b\u8f6c\u5411\u4e09\u7ef4\u57f9\u517b\u7cfb\u7edf\uff08\u5982\u7403\u4f53\u3001\u7c7b\u5668\u5b98\uff09\u548c\u751f\u7269\u6253\u5370\u6280\u672f\uff0c\u80fd\u66f4\u771f\u5b9e\u5730\u6a21\u62df\u4f53\u5185\u590d\u6742\u7684\u795e\u7ecf\u5fae\u73af\u5883\u30023D\u57f9\u517b\u80fd\u66f4\u597d\u5730\u7ef4\u6301\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u7684\u751f\u7406\u529f\u80fd\u3001\u589e\u5f3a\u5176\u5206\u6ccc\u6d3b\u6027\u53ca\u5bf9\u9006\u5883\u7684\u62b5\u6297\u80fd\u529b\u3002<\/p>\n<p>\u800c\u751f\u7269\u6253\u5370\u6280\u672f\u5219\u53ef\u4ee5\u6784\u5efa\u5305\u542b\u7ec6\u80de\u548c\u751f\u7269\u6750\u6599\u7684\u4e2a\u6027\u5316\u4e09\u7ef4\u7ed3\u6784\uff0c\u4e3a\u7cbe\u51c6\u4fee\u590d\u53d7\u635f\u795e\u7ecf\u7ec4\u7ec7\u548c\u5b9e\u73b0\u4e2a\u6027\u5316\u518d\u751f\u533b\u5b66\u63d0\u4f9b\u4e86\u5f3a\u5927\u7684\u5de5\u5177\u3002<\/p>\n<p><strong>\u9012\u9001\u4e0e\u6574\u5408\u7684\u4f18\u5316\uff1a\u751f\u7269\u6750\u6599\u4e0e\u795e\u7ecf\u5de5\u7a0b\uff1a<\/strong>\u5c06\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6216\u5176\u884d\u751f\u7269\u4e0e\u5148\u8fdb\u7684\u751f\u7269\u6750\u6599\u76f8\u7ed3\u5408\uff0c\u662f\u63d0\u5347\u7597\u6548\u7684\u5173\u952e\u7b56\u7565\u3002\u5229\u7528\u6c34\u51dd\u80f6\u3001\u7eb3\u7c73\u7ea4\u7ef4\u7b49\u751f\u7269\u76f8\u5bb9\u6027\u6750\u6599\u4f5c\u4e3a\u8f7d\u4f53\uff0c\u53ef\u4ee5\u8fdb\u884c\u5c40\u90e8\u5b9a\u4f4d\u9012\u9001\u3001\u5ef6\u957f\u4f5c\u7528\u65f6\u95f4\u5e76\u63d0\u9ad8\u7ec6\u80de\u79fb\u690d\u540e\u7684\u5b58\u6d3b\u7387\u3002<\/p>\n<p>\u6b64\u5916\uff0c\u6574\u5408\u78c1\u5bfc\u5411\u7cfb\u7edf\u3001\u5bfc\u7535\u7eb3\u7c73\u6750\u6599\u7b49\u795e\u7ecf\u5de5\u7a0b\u6280\u672f\uff0c\u80fd\u8fdb\u4e00\u6b65\u5b9e\u73b0\u6cbb\u7597\u5242\u5411\u7279\u5b9a\u75c5\u7076\u7684\u9776\u5411\u8f93\u9001\uff0c\u5e76\u4e0e\u795e\u7ecf\u7ec4\u7ec7\u8fdb\u884c\u66f4\u6709\u6548\u7684\u6574\u5408\uff0c\u4ece\u800c\u6700\u5927\u5316\u4fee\u590d\u6548\u679c\u3002<\/p>\n<p>\u56e0\u6b64\uff0c\u65b0\u5174\u7684\u57fa\u4e8e\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09\u7684\u7b56\u7565\u4e3a\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u63d0\u4f9b\u4e86\u66f4\u5f3a\u7684\u6cbb\u7597\u6f5c\u529b\u3002MSCs\u7684\u884d\u751f\u7269\uff0c\u5982\u5916\u6ccc\u4f53\u548c\u5fae\u56ca\u6ce1\uff0c\u5df2\u5c55\u73b0\u51fa\u795e\u7ecf\u4fdd\u62a4\u548c\u514d\u75ab\u8c03\u8282\u4f5c\u7528\uff0c\u4f46\u5176\u5185\u5bb9\u7269\u7684\u5f02\u8d28\u6027\u4ee5\u53ca\u4e34\u5e8a\u9a8c\u8bc1\u7684\u4e0d\u8db3\u4ecd\u662f\u5f53\u524d\u9762\u4e34\u7684\u6311\u6218\u3002<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%E7%BB%93%E8%AE%BA\"><\/span><strong>reach a verdict<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>\u5f53\u524d\u673a\u5236\u5171\u8bc6\u4e0e\u4e34\u5e8a\u8f6c\u5316\u74f6\u9888\uff1a\u5171\u8bc6\u8ba4\u4e3a\uff0cMSCs\u4e3b\u8981\u901a\u8fc7\u65c1\u5206\u6ccc\uff08\u5c24\u5176\u662fEVs\uff09\u548c\u4e3b\u52a8\u514d\u75ab\u8c03\u8282\u53d1\u6325\u7597\u6548\uff0c\u800c\u975e\u7ec6\u80de\u66ff\u4ee3\u3002\u7136\u800c\uff0c\u4f4e\u690d\u5165\u7387\u3001\u7597\u6548\u5f02\u8d28\u6027\u3001\u673a\u5236\u590d\u6742\u6027\u53ca\u6f5c\u5728\u5b89\u5168\u98ce\u9669\uff0c\u5171\u540c\u6784\u6210\u4e86\u5176\u5411\u5e38\u89c4\u4e34\u5e8a\u8f6c\u5316\u7684\u4e3b\u8981\u74f6\u9888\u3002<\/p>\n<p><strong>\u6838\u5fc3\u673a\u5236\uff1a\u8d85\u8d8a\u65c1\u5206\u6ccc\u7684\u4e3b\u52a8\u514d\u75ab\u8c03\u63a7\uff1a<\/strong>MSCs\u901a\u8fc7\u8c03\u63a7\u5de8\u566c\u7ec6\u80de\/\u5c0f\u80f6\u8d28\u7ec6\u80de\u8868\u578b\u3001\u8bf1\u5bfc\u8c03\u8282\u6027T\u7ec6\u80de\u7b49\uff0c\u4e3b\u52a8\u91cd\u5851\u635f\u4f24\u5c40\u90e8\u514d\u75ab\u5fae\u73af\u5883\uff0c\u8fd9\u662f\u5176\u53d1\u6325\u795e\u7ecf\u4fdd\u62a4\u4e0e\u4fee\u590d\u4f5c\u7528\u7684\u5173\u952e\u3002\u7406\u89e3\u8fd9\u4e00\u591a\u91cd\u673a\u5236\u6846\u67b6\uff0c\u6709\u52a9\u4e8e\u89e3\u91ca\u4e34\u5e8a\u7ed3\u679c\u5dee\u5f02\u5e76\u6307\u5bfc\u7b56\u7565\u4f18\u5316\u3002<\/p>\n<p><strong>\u672a\u6765\u8def\u5f84\uff1a\u6280\u672f\u6574\u5408\u4e0e\u6807\u51c6\u5316\u63a8\u8fdb\uff1a<\/strong>\u65b0\u5174\u6280\u672f\uff08\u65e0\u7ec6\u80de\u7597\u6cd5\u3001\u57fa\u56e0\u7f16\u8f91\u30013D\u751f\u7269\u5236\u9020\u3001\u5de5\u7a0b\u5316\u9012\u9001\uff09\u4e3a\u63d0\u5347\u7597\u6548\u548c\u5b89\u5168\u6027\u5f00\u8f9f\u4e86\u65b0\u9053\u8def\u3002<\/p>\n<p><strong>\u672a\u6765\u7684\u6210\u529f\u8f6c\u5316\uff0c\u53d6\u51b3\u4e8e\u5173\u952e\u4efb\u52a1\u7684\u89e3\u51b3\uff1a<\/strong>\u786e\u4fdd\u57fa\u56e0\u7f16\u8f91\u5b89\u5168\u3001\u5efa\u7acb\u7b26\u5408GMP\u6807\u51c6\u7684\u6807\u51c6\u5316\u751f\u4ea7\u4e0e\u8d28\u63a7\u4f53\u7cfb\uff0c\u4ee5\u53ca\u901a\u8fc7\u8bbe\u8ba1\u4e25\u8c28\u7684\u5927\u89c4\u6a21\u968f\u673a\u5bf9\u7167\u4e34\u5e8a\u8bd5\u9a8c\u83b7\u5f97\u786e\u8bc1\u6027\u7597\u6548\u8bc1\u636e\u3002\u552f\u6709\u5982\u6b64\uff0c\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u53ca\u5176\u884d\u751f\u7269\u65b9\u80fd\u771f\u6b63\u6210\u4e3a\u518d\u751f\u795e\u7ecf\u75c5\u5b66\u4e2d\u53ef\u9760\u7684\u6cbb\u7597\u5de5\u5177\u3002<\/p>\n<\/section>\n<\/section>\n<blockquote><p>References:<\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">[1] <\/span><\/span><span data-pm-slice=\"0 0 []\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">Akhmetzyanova, E.; Shulman, I.; Fakhrutdinova, T.; Rizvanov, A.; Mukhamedshina, Y. \u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u53ca\u5176\u884d\u751f\u7269\uff1a\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u518d\u751f\u533b\u5b66\u4e2d\u7684\u65e7\u95ee\u9898\u4e0e\u65b0\u673a\u9047\u3002Biologics\u00a0 <\/span><\/span><\/span><span dir=\"auto\" style=\"vertical-align: inherit;\"><b><span dir=\"auto\" style=\"vertical-align: inherit;\">2025 <\/span><\/b><\/span><em><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">,<\/span><\/span><\/em>\u00a0<span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> 5\u00a0 <\/span><em><span dir=\"auto\" style=\"vertical-align: inherit;\">,<\/span><\/em><span dir=\"auto\" style=\"vertical-align: inherit;\"> 37. https:\/\/doi.org\/10.3390\/biologics5040037<\/span><\/span><b><\/b><\/p>\n<p>Disclaimer: This article is intended only to disseminate scientific knowledge and share industry perspectives, and does not constitute any clinical diagnostic advice! The information published by Hangi Stem Cells is not a substitute for the professional advice of a physician or pharmacist. If you have any questions about copyright or other issues, please feel free to contact me.<\/p><\/blockquote>","protected":false},"excerpt":{"rendered":"<p>\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\uff0c\u5982\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u3001\u5e15\u91d1\u68ee\u75c5\u3001\u4e2d\u98ce\u548c\u810a\u9ad3\u635f\u4f24\uff0c\u4e00\u76f4\u662f\u4eba\u7c7b\u5065\u5eb7\u7684\u91cd\u5927\u5a01\u80c1\uff0c\u7ed9\u60a3\u8005\u53ca\u5176\u5bb6\u5ead\u5e26\u6765\u6c89\u91cd\u7684\u8d1f\u62c5 [&hellip;]<\/p>","protected":false},"author":1,"featured_media":20731,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[76],"tags":[247,178],"_links":{"self":[{"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/posts\/20730"}],"collection":[{"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/comments?post=20730"}],"version-history":[{"count":2,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/posts\/20730\/revisions"}],"predecessor-version":[{"id":20747,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/posts\/20730\/revisions\/20747"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/media\/20731"}],"wp:attachment":[{"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/media?parent=20730"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/categories?post=20730"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/tags?post=20730"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}