{"id":20778,"date":"2025-12-05T15:33:57","date_gmt":"2025-12-05T07:33:57","guid":{"rendered":"https:\/\/www.hjtdsm.cn\/?p=20778"},"modified":"2025-12-05T15:34:31","modified_gmt":"2025-12-05T07:34:31","slug":"https-www-hjtdsm-cn-stem-cells-nsc-20778-html","status":"publish","type":"post","link":"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/nsc\/20778.html","title":{"rendered":"\u795e\u7ecf\u5e72\u7ec6\u80de\u79fb\u690d\u6cbb\u7597\u8111\u51fa\u8840\u7684\u7cfb\u7edf\u8bc4\u4ef7\uff1aNSC\u6765\u6e90\u3001\u8f93\u9001\u9014\u5f84\u3001\u6cbb\u7597\u673a\u5236\u548c\u65e9\u671f\u4e34\u5e8a\u8bd5\u9a8c"},"content":{"rendered":"<section data-role=\"list\" data-pm-slice=\"4 4 [&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;outer&quot;,&quot;label&quot;:&quot;edit by 135editor&quot;,&quot;data-pm-slice&quot;:&quot;0 0 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https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-05_134652_279-300x133.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-05_134652_279-1024x453.png 1024w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-05_134652_279-768x340.png 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-05_134652_279-18x8.png 18w\" sizes=\"(max-width: 1028px) 100vw, 1028px\" \/><\/section>\n<p>\u7efc\u8ff0\u7ed3\u679c\u8868\u660e\uff0c\u795e\u7ecf\u5e72\u7ec6\u80de\u79fb\u690d\u6cbb\u7597\u8111\u51fa\u8840\u7684\u673a\u5236\u6db5\u76d6\u66ff\u4ee3\u795e\u7ecf\u5143\u3001\u514d\u75ab\u8c03\u8282\u4e0e\u4fc3\u8fdb\u8840\u7ba1\u751f\u6210\u7b49\u591a\u91cd\u9014\u5f84\uff1b\u5176\u6765\u6e90\u53ef\u5206\u4e3a\u5185\u6e90\u6027\u6fc0\u6d3b\u4e0e\u5916\u6e90\u6027\u79fb\u690d\uff0c\u540e\u8005\u5305\u62ec\u539f\u4ee3\u57f9\u517b\u3001\u591a\u80fd\u5e72\u7ec6\u80de\u5206\u5316\u53ca\u4f53\u7ec6\u80de\u91cd\u7f16\u7a0b\uff1b\u8f93\u9001\u9014\u5f84\u4e3b\u8981\u6709\u7acb\u4f53\u5b9a\u5411\u8111\u5185\u6ce8\u5c04\u3001\u7ecf\u8111\u810a\u6db2\u79fb\u690d\u53ca\u8840\u7ba1\u5185\u6ce8\u5c04\uff0c\u5404\u6709\u4f18\u52a3\u3002<\/p>\n<p>\u5c3d\u7ba1\u4e34\u5e8a\u524d\u7814\u7a76\u8bc1\u636e\u79ef\u6781\uff0c\u4f46\u65e9\u671f\u4e34\u5e8a\u8bd5\u9a8c\u89c4\u6a21\u6709\u9650\uff0c\u4e14\u9762\u4e34\u79fb\u690d\u53c2\u6570\u6807\u51c6\u5316\u3001\u5b89\u5168\u6027\u53ca\u8f6c\u5316\u533b\u5b66\u7b49\u591a\u91cd\u6311\u6218\u3002\u672a\u6765\u9700\u901a\u8fc7\u4e25\u8c28\u7684\u4e34\u5e8a\u8bd5\u9a8c\u4e0e\u6280\u672f\u521b\u65b0\u63a8\u52a8\u8be5\u7597\u6cd5\u5411\u6807\u51c6\u5316\u4e34\u5e8a\u5e94\u7528\u7684\u8f6c\u5316\u3002<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%E8%84%91%E5%87%BA%E8%A1%80%E7%9A%84%E6%B2%BB%E7%96%97%E6%8C%91%E6%88%98%E4%B8%8E%E4%B8%B4%E5%BA%8A%E9%9C%80%E6%B1%82\"><\/span><strong>\u8111\u51fa\u8840\u7684\u6cbb\u7597\u6311\u6218\u4e0e\u4e34\u5e8a\u9700\u6c42<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>\u8111\u51fa\u8840\uff08ICH\uff09\u662f\u4e00\u79cd\u7531\u9ad8\u8840\u538b\u3001\u8111\u8840\u7ba1\u75c5\u53d8\u7b49\u56e0\u7d20\u5f15\u53d1\u7684\u8111\u5185\u81ea\u53d1\u6027\u51fa\u8840\uff0c\u75c5\u60c5\u51f6\u9669\uff0c\u65e9\u671f\u6b7b\u4ea1\u7387\u9ad8\u8fbe30%-47%\uff0c\u591a\u6570\u5e78\u5b58\u8005\u9057\u7559\u4e25\u91cd\u6b8b\u75be\u3002\u5f53\u524d\u6807\u51c6\u6cbb\u7597\u65e8\u5728\u9884\u9632\u518d\u51fa\u8840\u548c\u7ba1\u7406\u7ee7\u53d1\u6027\u635f\u4f24\uff0c\u4f46\u5bf9\u53d7\u635f\u795e\u7ecf\u7ec4\u7ec7\u7684\u4fee\u590d\u80fd\u529b\u6709\u9650\uff0c\u5bfc\u81f4\u603b\u4f53\u9884\u540e\u4e0d\u4f73\u3002<\/p>\n<section><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-20780 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/istockphoto-2190631427-612x612-1.jpg\" alt=\"\u795e\u7ecf\u5e72\u7ec6\u80de\u79fb\u690d\u6cbb\u7597\u8111\u51fa\u8840\u7684\u7cfb\u7edf\u8bc4\u4ef7\uff1aNSC\u6765\u6e90\u3001\u8f93\u9001\u9014\u5f84\u3001\u6cbb\u7597\u673a\u5236\u548c\u65e9\u671f\u4e34\u5e8a\u8bd5\u9a8c\" width=\"612\" height=\"409\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/istockphoto-2190631427-612x612-1.jpg 612w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/istockphoto-2190631427-612x612-1-300x200.jpg 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/istockphoto-2190631427-612x612-1-18x12.jpg 18w\" sizes=\"(max-width: 612px) 100vw, 612px\" \/><\/section>\n<h2><span class=\"ez-toc-section\" id=\"%E7%A5%9E%E7%BB%8F%E5%B9%B2%E7%BB%86%E8%83%9E%EF%BC%9A%E4%B8%80%E7%A7%8D%E6%9E%81%E5%85%B7%E5%89%8D%E6%99%AF%E7%9A%84%E4%BF%AE%E5%A4%8D%E7%AD%96%E7%95%A5\"><\/span><strong>\u795e\u7ecf\u5e72\u7ec6\u80de\uff1a\u4e00\u79cd\u6781\u5177\u524d\u666f\u7684\u4fee\u590d\u7b56\u7565<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>\u9274\u4e8e\u4f20\u7edf\u7597\u6cd5\u7684\u5c40\u9650\uff0c\u4fee\u590d\u53d7\u635f\u795e\u7ecf\u6216\u523a\u6fc0\u795e\u7ecf\u65b0\u751f\u6210\u4e3a\u6539\u5584\u9884\u540e\u7684\u5173\u952e\u65b9\u5411\u3002\u5e72\u7ec6\u80de\u7597\u6cd5\u51ed\u501f\u5176\u81ea\u6211\u66f4\u65b0\u53ca\u591a\u5411\u5206\u5316\u80fd\u529b\uff0c\u4e3a\u795e\u7ecf\u4fee\u590d\u63d0\u4f9b\u4e86\u5168\u65b0\u53ef\u80fd\u3002\u5176\u4e2d\uff0c\u6e90\u81ea\u795e\u7ecf\u7cfb\u7edf\u7684<a href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/nsc\/20413.html\/\" target=\"_blank\" rel=\"noopener\">Neural Stem Cells (NSC)<\/a>\u80fd\u591f\u76f4\u63a5\u4ea7\u751f\u795e\u7ecf\u5143\u3001\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u7b49\uff0c\u5907\u53d7\u5173\u6ce8\u3002<\/p>\n<section><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-20779 size-full aligncenter\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/istockphoto-1051686896-612x612-1.jpg\" alt=\"\" width=\"612\" height=\"350\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/istockphoto-1051686896-612x612-1.jpg 612w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/istockphoto-1051686896-612x612-1-300x172.jpg 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/istockphoto-1051686896-612x612-1-18x10.jpg 18w\" sizes=\"(max-width: 612px) 100vw, 612px\" \/><\/section>\n<p>\u795e\u7ecf\u5e72\u7ec6\u80de\u81ea1992\u5e74\u88ab\u53d1\u73b0\u4ee5\u6765\uff0c\u88ab\u8bc1\u5b9e\u5177\u6709\u957f\u671f\u9759\u606f\u3001\u5728\u635f\u4f24\u540e\u88ab\u6fc0\u6d3b\u4ee5\u53c2\u4e0e\u4fee\u590d\u7684\u7279\u6027\u3002\u6700\u65b0\u7814\u7a76\u8fdb\u4e00\u6b65\u63ed\u793a\uff0c\u5176\u6d3b\u6027\u53d7\u5230\u6df1\u5c42\u4ee3\u8c22\u4fe1\u53f7\u7684\u7cbe\u5bc6\u8c03\u63a7\u3002\u4f8b\u5982\uff0c\u7ebf\u7c92\u4f53\u4e19\u916e\u9178\u8f7d\u4f53\u7684\u529f\u80fd\u72b6\u6001\u80fd\u5f71\u54cd\u795e\u7ecf\u5e72\/\u7956\u7ec6\u80de\u662f\u4fdd\u6301\u9759\u606f\u8fd8\u662f\u6fc0\u6d3b\u8fdb\u884c\u518d\u751f\uff0c\u8fd9\u4e3a\u672a\u6765\u901a\u8fc7\u8c03\u63a7\u7ec6\u80de\u4ee3\u8c22\u6765\u589e\u5f3a\u4fee\u590d\u7597\u6548\u63d0\u4f9b\u4e86\u65b0\u601d\u8def\u3002<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%E7%A0%94%E7%A9%B6%E8%BF%9B%E5%B1%95%E4%B8%8E%E7%BB%BC%E8%BF%B0%E7%9B%AE%E6%A0%87\"><\/span><strong>\u7814\u7a76\u8fdb\u5c55\u4e0e\u7efc\u8ff0\u76ee\u6807<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>\u7efc\u4e0a\u6240\u8ff0\uff0c\u795e\u7ecf\u5e72\u7ec6\u80de\u79fb\u690d\u901a\u8fc7\u6291\u5236\u708e\u75c7\u3001\u5206\u5316\u4e3a\u529f\u80fd\u6027\u795e\u7ecf\u5143\u4ee5\u53ca\u4fc3\u8fdb\u795e\u7ecf\u4fdd\u62a4\u4e0e\u795e\u7ecf\u53d1\u751f\uff0c\u5c55\u73b0\u51fa\u663e\u8457\u7684\u6cbb\u7597\u6f5c\u529b\uff0c\u4f7f\u5176\u6210\u4e3a\u6cbb\u7597\u8111\u51fa\u8840\u7684\u4e00\u79cd\u6709\u524d\u666f\u7684\u65b9\u6cd5\u3002\u672c\u6587\u65e8\u5728\u7cfb\u7edf\u7efc\u8ff0\u76ee\u524d\u5173\u4e8e\u795e\u7ecf\u5e72\u7ec6\u80de\u5728\u8111\u51fa\u8840\u6cbb\u7597\u4e2d\u7684\u7814\u7a76\u8fdb\u5c55\uff0c\u91cd\u70b9\u5173\u6ce8\u5176\u6765\u6e90\u3001\u7ed9\u836f\u9014\u5f84\u3001\u4f5c\u7528\u673a\u5236\u53ca\u4e34\u5e8a\u8f6c\u5316\u610f\u4e49\u3002<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%E7%B3%BB%E7%BB%9F%E8%AF%84%E4%BB%B7%E7%A5%9E%E7%BB%8F%E5%B9%B2%E7%BB%86%E8%83%9E%E5%9C%A8%E8%84%91%E5%87%BA%E8%A1%80%E6%B2%BB%E7%96%97%E4%B8%AD%E5%BA%94%E7%94%A8%E7%9A%84%E6%96%B9%E6%B3%95\"><\/span><strong>\u7cfb\u7edf\u8bc4\u4ef7\u795e\u7ecf\u5e72\u7ec6\u80de\u5728\u8111\u51fa\u8840\u6cbb\u7597\u4e2d\u5e94\u7528\u7684\u65b9\u6cd5<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>\u672c\u7814\u7a76\u4e25\u683c\u9075\u5faa\u7cfb\u7edf\u8bc4\u4ef7\u548cMeta\u5206\u6790\u7684\u9996\u9009\u62a5\u544a\u6761\u76ee\u6307\u5357\u5f00\u5c55\u3002\u6587\u732e\u68c0\u7d22\u8986\u76d6\u4e86PubMed\u3001Embase\u3001<span class=\"\">Web of Science<\/span>\u3001ClinicalTrials.gov\u53ca\u4e2d\u56fd\u4e34\u5e8a\u8bd5\u9a8c\u6ce8\u518c\u4e2d\u5fc3\u5171\u4e94\u4e2a\u6570\u636e\u5e93\uff0c\u68c0\u7d22\u65f6\u95f4\u8303\u56f4\u4e3a1990\u5e741\u6708\u81f32025\u5e748\u6708\u3002\u6211\u4eec\u91c7\u7528\u201c\u795e\u7ecf\u5e72\u7ec6\u80de\u201d\u3001\u201c\u8111\u51fa\u8840\u201d\u53ca\u5176\u76f8\u5173\u540c\u4e49\u8bcd\u4e0e\u7f29\u5199\u7ec4\u5408\u4f5c\u4e3a\u68c0\u7d22\u8bcd\u3002\u521d\u6b65\u68c0\u7d22\u5171\u83b7\u5f971250\u6761\u8bb0\u5f55\u3002<\/p>\n<p>\u6587\u732e\u7b5b\u9009\u7531\u4e24\u4f4d\u7814\u7a76\u8005\u72ec\u7acb\u5b8c\u6210\uff0c\u9996\u5148\u4f9d\u636e\u6807\u9898\u548c\u6458\u8981\u8fdb\u884c\u521d\u7b5b\uff0c\u968f\u540e\u5bf9\u53ef\u80fd\u7b26\u5408\u8981\u6c42\u7684\u6587\u732e\u8fdb\u884c\u5168\u6587\u7b5b\u9009\uff0c\u5e76\u901a\u8fc7\u8ba8\u8bba\u89e3\u51b3\u5206\u6b67\u3002\u7eb3\u5165\u6807\u51c6\u9650\u5b9a\u4e3a\u63a2\u8ba8\u795e\u7ecf\u5e72\u7ec6\u80de\u5e94\u7528\u4e8e\u8111\u51fa\u8840\u7684\u540c\u884c\u8bc4\u5ba1\u82f1\u6587\u7814\u7a76\uff08\u4e34\u5e8a\u524d\u6216\u4e34\u5e8a\u8bd5\u9a8c\uff09\uff0c\u6392\u9664\u7efc\u8ff0\u3001\u75c5\u4f8b\u62a5\u544a\u53ca\u975e\u76f8\u5173\u7814\u7a76\u7c7b\u578b\u3002<\/p>\n<p>\u6700\u7ec8\uff0c\u517168\u9879\u7814\u7a76\u88ab\u7eb3\u5165\u672c\u7cfb\u7edf\u8bc4\u4ef7\u3002\u6211\u4eec\u63d0\u53d6\u4e86\u7814\u7a76\u8bbe\u8ba1\u3001\u7ec6\u80de\u6765\u6e90\u4e0e\u79fb\u690d\u53c2\u6570\u3001\u7ed3\u5c40\u6307\u6807\u53ca\u673a\u5236\u7b49\u6570\u636e\uff0c\u5e76\u4f7f\u7528SYRCLE\u548cCochrane\u5de5\u5177\u5206\u522b\u8bc4\u4f30\u4e34\u5e8a\u524d\u7814\u7a76\u4e0e\u4e34\u5e8a\u8bd5\u9a8c\u7684\u504f\u501a\u98ce\u9669\u3002\u9274\u4e8e\u7eb3\u5165\u7814\u7a76\u5b58\u5728\u8f83\u9ad8\u7684\u5f02\u8d28\u6027\uff0c\u672c\u6b21\u672a\u8fdb\u884c\u835f\u8403\u5206\u6790\u3002<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%E7%A5%9E%E7%BB%8F%E5%B9%B2%E7%BB%86%E8%83%9E%E7%9A%84%E6%9D%A5%E6%BA%90\"><\/span><strong>\u795e\u7ecf\u5e72\u7ec6\u80de\u7684\u6765\u6e90<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>\u7528\u4e8e\u635f\u4f24\u4fee\u590d\u7684\u795e\u7ecf\u5e72\u7ec6\u80de\u53ef\u5206\u4e3a\u5185\u6e90\u6027\u548c\u5916\u6e90\u6027\u4e24\u7c7b\u3002\u73b0\u6709\u7814\u7a76\u8868\u660e\uff0c\u6fc0\u6d3b\u4f11\u7720\u7684<span class=\"\">\u5185\u6e90\u6027\u795e\u7ecf\u5e72\u7ec6\u80de<\/span>\u548c\u79fb\u690d\u5916\u6e90\u6027\u795e\u7ecf\u5e72\u7ec6\u80de\u5747\u53ef\u5206\u6ccc\u795e\u7ecf\u8425\u517b\u56e0\u5b50\uff0c\u4ece\u800c\u6539\u5584\u5176\u751f\u957f\u5fae\u73af\u5883\uff0c\u6291\u5236\u708e\u75c7\uff0c\u4fc3\u8fdb\u6062\u590d\uff0c\u5e76\u5206\u5316\u4e3a\u795e\u7ecf\u5143\uff0c\u6700\u7ec8\u6062\u590d\u53d7\u635f\u533a\u57df\u4e27\u5931\u7684\u795e\u7ecf\u529f\u80fd\u3002<\/p>\n<h3><span class=\"ez-toc-section\" id=\"%E7%A5%9E%E7%BB%8F%E5%B9%B2%E7%BB%86%E8%83%9E%E7%9A%84%E5%86%85%E6%BA%90%E6%80%A7%E6%9D%A5%E6%BA%90\"><\/span>\u795e\u7ecf\u5e72\u7ec6\u80de\u7684\u5185\u6e90\u6027\u6765\u6e90<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u5185\u6e90\u6027\u795e\u7ecf\u5e72\u7ec6\u80de\u662f\u6307\u6210\u5e74\u751f\u7269\u4f53\u5185\u81ea\u7136\u5b58\u5728\u3001\u5177\u6709\u81ea\u6211\u66f4\u65b0\u6f5c\u80fd\u7684\u7ec6\u80de\u7fa4\uff0c\u4e3b\u8981\u4f4d\u4e8e\u6d77\u9a6c\u9f7f\u72b6\u56de\u548c\u8111\u5ba4\u4e0b\u533a\u3002\u6b63\u5e38\u60c5\u51b5\u4e0b\u5b83\u4eec\u5904\u4e8e\u9759\u606f\u72b6\u6001\uff0c\u4f46\u5728ICH\u7b49\u635f\u4f24\u540e\u53ef\u88ab\u6fc0\u6d3b\u3001\u5e76\u5b9a\u5411\u8fc1\u79fb\u81f3\u53d7\u635f\u533a\u57df\uff0c\u901a\u8fc7\u589e\u6b96\u548c\u5206\u5316\u53c2\u4e0e\u795e\u7ecf\u4fee\u590d\u8fc7\u7a0b\u3002<\/p>\n<p>\u5916\u90e8\u5e72\u9884\u5982\u91cd\u590d\u7ecf\u9885\u78c1\u523a\u6fc0\u3001\u4e0a\u8c03HIF-1\u03b1\u6216\u4f53\u80b2\u953b\u70bc\uff0c\u5747\u53ef\u589e\u5f3a\u5176\u6d3b\u6027\u3002\u5185\u6e90\u6027NSC\u5177\u6709\u4f4e\u514d\u75ab\u539f\u6027\u3001\u65e0\u6392\u65a5\u98ce\u9669\u7684\u4f18\u52bf\uff0c\u4f46\u5176\u6570\u91cf\u6709\u9650\u3001\u8fc1\u79fb\u6548\u7387\u4f4e\uff0c\u4e14\u6fc0\u6d3b\u5206\u5316\u673a\u5236\u4e0d\u660e\uff0c\u9650\u5236\u4e86\u5176\u76f4\u63a5\u6cbb\u7597\u5e94\u7528\u3002<\/p>\n<h3><span class=\"ez-toc-section\" id=\"%E7%A5%9E%E7%BB%8F%E5%B9%B2%E7%BB%86%E8%83%9E%E7%9A%84%E5%A4%96%E6%BA%90%E6%80%A7%E6%9D%A5%E6%BA%90\"><\/span>\u795e\u7ecf\u5e72\u7ec6\u80de\u7684\u5916\u6e90\u6027\u6765\u6e90<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u795e\u7ecf\u5e72\u7ec6\u80de\u7684\u5916\u6e90\u6027\u6765\u6e90\u9996\u5148\u5305\u62ec\u901a\u8fc7\u539f\u4ee3\u7ec4\u7ec7\u57f9\u517b\u6280\u672f\u76f4\u63a5\u4ece\u751f\u7269\u4f53\u795e\u7ecf\u7ec4\u7ec7\u4e2d\u83b7\u53d6\u3002\u4f8b\u5982\uff0c\u4ece\u5c0f\u9f20\u5168\u8111\u6216\u8111\u635f\u4f24\u60a3\u8005\u7684\u5e9f\u5f03\u8111\u7ec4\u7ec7\u4e2d\u5206\u79bb\u5e76\u57f9\u517b\u795e\u7ecf\u5e72\u7ec6\u80de\uff0c\u518d\u8bf1\u5bfc\u5176\u5206\u5316\u4e3a\u795e\u7ecf\u5143\u3002\u7136\u800c\uff0c\u8fd9\u79cd\u65b9\u6cd5\u9762\u4e34\u7ec6\u80de\u4ea7\u91cf\u4f4e\u3001\u5206\u5316\u6548\u7387\u6709\u9650\u4ee5\u53ca\u7ef4\u6301\u7ec6\u80de\u4f20\u4ee3\u7a33\u5b9a\u6027\u7b49\u6311\u6218\uff0c\u5c3d\u7ba1\u751f\u957f\u56e0\u5b50\u5e94\u7528\u548c3D\u57f9\u517b\u7b49\u65b0\u5174\u6280\u672f\u6709\u671b\u63d0\u5347\u5176\u89c4\u6a21\u5316\u5e94\u7528\u6f5c\u529b\u3002<\/p>\n<p>\u5176\u6b21\uff0c\u591a\u80fd\u5e72\u7ec6\u80de\u5206\u5316\u662f\u53e6\u4e00\u91cd\u8981\u5916\u6e90\u6027\u9014\u5f84\uff0c\u4e3b\u8981\u5305\u62ec<a href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/psc\/19896.html\/\" target=\"_blank\" rel=\"noopener\">embryonic stem cell<\/a>\u548c\u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de\u3002\u80da\u80ce\u5e72\u7ec6\u80de\u867d\u80fd\u5206\u5316\u4e3a\u795e\u7ecf\u5e72\u7ec6\u80de\uff0c\u4f46\u5b58\u5728\u4f26\u7406\u4e89\u8bae\u3001\u514d\u75ab\u6392\u65a5\u548c\u81f4\u7624\u98ce\u9669\uff1b\u800c\u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de\u901a\u8fc7\u4f53\u7ec6\u80de\u91cd\u7f16\u7a0b\u83b7\u5f97\uff0c\u907f\u514d\u4e86\u4f26\u7406\u95ee\u9898\uff0c\u4f46\u5236\u5907\u8fc7\u7a0b\u8017\u65f6\u4e14\u5b58\u5728\u7c7b\u4f3c\u7684\u5b89\u5168\u9690\u60a3\uff0c\u5236\u7ea6\u4e86\u5176\u4e34\u5e8a\u8f6c\u5316\u3002<\/p>\n<p>\u6700\u540e\uff0c\u4f53\u7ec6\u80de\u91cd\u7f16\u7a0b\u548c\u8f6c\u5206\u5316\u6280\u672f\u63d0\u4f9b\u4e86\u66f4\u76f4\u63a5\u7684\u751f\u6210\u65b9\u5f0f\uff0c\u4f8b\u5982\u5229\u7528\u75c5\u6bd2\u8f7d\u4f53\u6216\u8f6c\u5f55\u56e0\u5b50\u5c06\u6210\u7ea4\u7ef4\u7ec6\u80de\u7b49\u4f53\u7ec6\u80de\u8f6c\u5316\u4e3a\u795e\u7ecf\u5e72\u7ec6\u80de\u6216\u795e\u7ecf\u5143\u3002\u5c3d\u7ba1\u8f6c\u5206\u5316\u65b9\u6cd5\u76f8\u5bf9\u7b80\u4fbf\uff0c\u4f46\u75c5\u6bd2\u8f7d\u4f53\u53ef\u80fd\u5e26\u6765\u81f4\u7624\u98ce\u9669\uff0c\u4e14\u8f6c\u5316\u8fc7\u7a0b\u53ef\u80fd\u4ea7\u751f\u4e0d\u5fc5\u8981\u7684\u526f\u4ea7\u7269\uff0c\u4ecd\u9700\u8fdb\u4e00\u6b65\u4f18\u5316\u4ee5\u63d0\u9ad8\u5b89\u5168\u6027\u4e0e\u6548\u7387\u3002<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%E7%A5%9E%E7%BB%8F%E5%B9%B2%E7%BB%86%E8%83%9E%E7%A7%BB%E6%A4%8D%E9%80%94%E5%BE%84\"><\/span><strong>\u795e\u7ecf\u5e72\u7ec6\u80de\u79fb\u690d\u9014\u5f84<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>\u76ee\u524d\uff0c\u795e\u7ecf\u5e72\u7ec6\u80de\u79fb\u690d\u4e3b\u8981\u901a\u8fc7\u8111\u5185\u79fb\u690d\u3001\u9798\u5185\/\u8111\u5ba4\u5185\u6ce8\u5c04\uff08\u7ecf\u8111\u810a\u6db2\u9014\u5f84\uff09\u3001\u8840\u7ba1\u5185\u6ce8\u5c04\u548c\u9f3b\u5185\u7ed9\u836f\u7b49\u9014\u5f84\u8fdb\u884c\u3002\u6700\u5e38\u7528\u7684\u65b9\u6cd5\u662f\u76f4\u63a5\u8111\u5185\u79fb\u690d\u3002\u7136\u800c\uff0c\u6bcf\u79cd\u65b9\u6cd5\u90fd\u6709\u5176\u72ec\u7279\u7684\u4f18\u7f3a\u70b9\uff0c\u76ee\u524d\u5c1a\u672a\u786e\u5b9a\u7edf\u4e00\u7684\u79fb\u690d\u9014\u5f84\uff08\u56fe1\uff09\u3002<\/p>\n<section>\n<div id=\"attachment_20788\" style=\"width: 819px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-20788\" class=\"wp-image-20788 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/fphar-16-1660614-g001.jpg\" alt=\"\" width=\"809\" height=\"590\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/fphar-16-1660614-g001.jpg 809w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/fphar-16-1660614-g001-300x219.jpg 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/fphar-16-1660614-g001-768x560.jpg 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/fphar-16-1660614-g001-16x12.jpg 16w\" sizes=\"(max-width: 809px) 100vw, 809px\" \/><p id=\"caption-attachment-20788\" class=\"wp-caption-text\">\u56fe1\uff1a\u5e72\u7ec6\u80de\u79fb\u690d\u9014\u5f84\uff1a\u8be5\u56fe\u5c55\u793a\u4e86\u7528\u4e8e\u4e2d\u98ce\u6cbb\u7597\u7684\u5e72\u7ec6\u80de\u8f93\u9001\u9014\u5f84\uff0c\u5305\u62ec\u8111\u5185\uff08\u7acb\u4f53\u5b9a\u5411\u6ce8\u5c04\uff09\u3001\u8840\u7ba1\u5185\uff08\u9759\u8109\/\u52a8\u8109\uff09\u3001\u8179\u8154\u5185\u3001\u8111\u5ba4\u5185\u3001\u9759\u8109\u5185\u3001\u9f3b\u5185\u548c\u9798\u5185\u6ce8\u5c04\u65b9\u6cd5\u3002<\/p><\/div>\n<\/section>\n<p>\uff08\u88681\u603b\u7ed3\u4e86\u5173\u952e\u8f6c\u5316\u53c2\u6570\uff0c\u5305\u62ec\u4e34\u5e8a\u524d\u548c\u4e34\u5e8a\u7814\u7a76\u4e2d\u7684\u9014\u5f84\u3001\u65f6\u95f4\u7a97\u548c\u5242\u91cf\uff09<\/p>\n<section>\n<div id=\"attachment_20787\" style=\"width: 1155px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-20787\" class=\"wp-image-20787 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/fphar-16-1660614-t001.jpg\" alt=\"\" width=\"1145\" height=\"368\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/fphar-16-1660614-t001.jpg 1145w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/fphar-16-1660614-t001-300x96.jpg 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/fphar-16-1660614-t001-1024x329.jpg 1024w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/fphar-16-1660614-t001-768x247.jpg 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/fphar-16-1660614-t001-18x6.jpg 18w\" sizes=\"(max-width: 1145px) 100vw, 1145px\" \/><p id=\"caption-attachment-20787\" class=\"wp-caption-text\">\u88681\uff1a\u795e\u7ecf\u5e72\u7ec6\u80de\u5728\u6cbb\u7597\u8111\u51fa\u8840\u7814\u7a76\u4e2d\u7684\u5173\u952e\u8f6c\u5316\u53c2\u6570\u603b\u7ed3\u3002<\/p><\/div>\n<\/section>\n<p><strong>1. \u7acb\u4f53\u5b9a\u5411\u8111\u5185\u6ce8\u5c04<\/strong><\/p>\n<p>\u8be5\u65b9\u6cd5\u662f\u76ee\u524d\u5b9a\u4f4d\u6700\u7cbe\u786e\u7684\u79fb\u690d\u65b9\u5f0f\uff0c\u901a\u8fc7\u7acb\u4f53\u5b9a\u5411\u6280\u672f\u5c06\u795e\u7ecf\u5e72\u7ec6\u80de\u60ac\u6db2\u76f4\u63a5\u8f93\u9001\u5230\u8840\u80bf\u8154\u6216\u635f\u4f24\u5468\u8fb9\u533a\u57df\u3002\u5176\u4f18\u52bf\u5728\u4e8e\u7ec6\u80de\u53ef\u88ab\u7cbe\u51c6\u9012\u9001\u81f3\u9776\u70b9\u3002\u7136\u800c\uff0c\u8840\u80bf\u8154\u5185\u7684\u6bd2\u6027\u8840\u6db2\u964d\u89e3\u4ea7\u7269\u548c\u53cd\u5e94\u6027\u80f6\u8d28\u589e\u751f\u5fae\u73af\u5883\u5bb9\u6613\u8bf1\u5bfc\u79fb\u690d\u7ec6\u80de\u6b7b\u4ea1\uff0c\u4e14\u8fc7\u9ad8\u7684\u5c40\u90e8\u7ec6\u80de\u5bc6\u5ea6\u53ef\u80fd\u53cd\u800c\u963b\u788d\u5176\u5b58\u6d3b\u4e0e\u5206\u5316\u3002\u4e3a\u63d0\u9ad8\u7ec6\u80de\u5b58\u6d3b\u7387\uff0c\u7814\u7a76\u5df2\u5f00\u53d1\u51fa\u7ecf\u8fc7\u57fa\u56e0\u4fee\u9970\u7684\u6297\u51cb\u4ea1\u795e\u7ecf\u5e72\u7ec6\u80de\uff0c\u6216\u5efa\u8bae\u5728\u6ce8\u5c04\u65f6\u8054\u5408\u4f7f\u7528\u795e\u7ecf\u8425\u517b\u56e0\u5b50\uff0c\u4f46\u8fd9\u4e9b\u7b56\u7565\u7684\u4e34\u5e8a\u6709\u6548\u6027\u4ecd\u9700\u8fdb\u4e00\u6b65\u9a8c\u8bc1\u3002<\/p>\n<p><strong>2. \u7ecf\u8111\u810a\u6db2\u9014\u5f84\u79fb\u690d<\/strong><\/p>\n<p>\u4e3b\u8981\u5305\u62ec\u8170\u690e\u7a7f\u523a\uff08\u9798\u5185\u6ce8\u5c04\uff09\u548c\u8111\u5ba4\u7a7f\u523a\u7b49\u65b9\u5f0f\u3002\u8170\u690e\u7a7f\u523a\u5c06\u795e\u7ecf\u5e72\u7ec6\u80de\u6ce8\u5165\u86db\u7f51\u819c\u4e0b\u8154\uff0c\u4f7f\u5176\u968f\u8111\u810a\u6db2\u5faa\u73af\u5e7f\u6cdb\u5206\u5e03\u4e8e\u8111\u548c\u810a\u9ad3\u8868\u9762\uff1b\u8111\u5ba4\u7a7f\u523a\u5219\u5c06\u7ec6\u80de\u76f4\u63a5\u9001\u5165\u4fa7\u8111\u5ba4\uff0c\u4fc3\u8fdb\u5176\u5feb\u901f\u5206\u5e03\uff0c\u5e76\u53ef\u80fd\u901a\u8fc7\u5206\u6ccc\u8425\u517b\u56e0\u5b50\u523a\u6fc0\u5185\u6e90\u6027\u795e\u7ecf\u5e72\u7ec6\u80de\u589e\u6b96\u3002\u6b64\u5916\uff0c\u6795\u5927\u6c60\u6ce8\u5c04\u56e0\u5b58\u5728\u8111\u5e72\u635f\u4f24\u98ce\u9669\uff0c\u76ee\u524d\u4e3b\u8981\u9650\u4e8e\u52a8\u7269\u5b9e\u9a8c\uff0c\u5c1a\u672a\u5e94\u7528\u4e8e\u4e34\u5e8a\u3002<\/p>\n<p><strong>3. \u8840\u7ba1\u5185\u6ce8\u5c04<\/strong><\/p>\n<p>\u53ef\u901a\u8fc7\u9759\u8109\u6216\u52a8\u8109\uff08\u5982\u9888\u5185\u52a8\u8109\uff09\u8fdb\u884c\u3002\u9759\u8109\u6ce8\u5c04\u64cd\u4f5c\u7b80\u4fbf\uff0c\u4f46\u5927\u91cf\u7ec6\u80de\u4f1a\u6ede\u7559\u5728\u80ba\u3001\u809d\u3001\u813e\u7b49\u5668\u5b98\uff0c\u5230\u8fbe\u8111\u90e8\u7684\u6548\u7387\u4f4e\uff1b\u52a8\u8109\u6ce8\u5c04\u867d\u80fd\u63d0\u9ad8\u8111\u90e8\u7ec6\u80de\u9012\u9001\u7387\uff0c\u4f46\u9762\u4e34\u6280\u672f\u96be\u5ea6\u3001\u64cd\u4f5c\u98ce\u9669\u4ee5\u53ca\u56e0\u7ec6\u80de\u805a\u96c6\u53ef\u80fd\u5f15\u53d1\u7684\u5fae\u6813\u585e\u98ce\u9669\u3002<\/p>\n<p>\u8fd9\u4e24\u79cd\u65b9\u5f0f\u5747\u53d7\u5230\u795e\u7ecf\u5e72\u7ec6\u80de\u81ea\u8eab\u8fc1\u79fb\u80fd\u529b\u6709\u9650\u3001\u8840\u8111\u5c4f\u969c\u963b\u788d\u4ee5\u53ca\u7f3a\u4e4f\u7279\u5f02\u6027\u9776\u5411\u5f52\u5de2\u4fe1\u53f7\u7684\u9650\u5236\u3002\u4f7f\u7528\u9776\u5411\u5206\u5b50\u4fee\u9970\u6216\u7eb3\u7c73\u6750\u6599\u8f7d\u4f53\u5305\u88f9\uff0c\u662f\u672a\u6765\u63d0\u9ad8\u8840\u7ba1\u5185\u9012\u9001\u7cbe\u786e\u5ea6\u7684\u7814\u7a76\u65b9\u5411\u3002\u603b\u4f53\u800c\u8a00\uff0c\u5c3d\u7ba1\u79fb\u690d\u7b56\u7565\u591a\u6837\uff0c\u5bfb\u627e\u5b89\u5168\u9ad8\u6548\u7684\u9014\u5f84\u4ecd\u662f\u5f53\u524d\u7814\u7a76\u7684\u91cd\u70b9\u3002<\/p>\n<p><strong>4. \u5176\u4ed6\u9014\u5f84<\/strong><\/p>\n<p>\u5305\u62ec\u9f3b\u5185\u7ed9\u836f\uff0c\u8be5\u65b9\u6cd5\u5229\u7528\u55c5\u795e\u7ecf\u901a\u8def\uff0c\u53ef\u65e0\u521b\u5730\u5c06\u7ec6\u80de\u9012\u9001\u81f3\u8111\u5185\uff0c\u6700\u5927\u9650\u5ea6\u5730\u51cf\u5c11\u7ee7\u53d1\u6027\u635f\u4f24\u3002\u4f8b\u5982\uff0cSun\u7b49\u4eba\u5728\u52a8\u7269\u6a21\u578b\u4e2d\u53d1\u73b0\uff0c\u9f3b\u5185\u7ed9\u4e88\u7f3a\u6c27\u9884\u5904\u7406\u7684\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u540e\uff0c\u80fd\u5728\u8111\u51fa\u8840\u8111\u7ec4\u7ec7\u4e2d\u68c0\u6d4b\u5230\u8fd9\u4e9b\u7ec6\u80de\u3002\u6b64\u5916\uff0c\u8179\u8154\u6ce8\u5c04\u4ee5\u53ca\u7ed3\u5408\u751f\u7269\u6750\u6599\u6216\u7eb3\u7c73\u6280\u672f\u7684\u8054\u5408\u7ed9\u836f\u9014\u5f84\uff0c\u4e5f\u5728\u63a2\u7d22\u4e2d\uff0c\u65e8\u5728\u8fdb\u4e00\u6b65\u63d0\u9ad8\u79fb\u690d\u7ec6\u80de\u7684\u5b58\u6d3b\u3001\u6ede\u7559\u548c\u9776\u5411\u6548\u7387\uff08\u56fe1\uff09\u3002<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%E7%A5%9E%E7%BB%8F%E5%B9%B2%E7%BB%86%E8%83%9E%E4%BF%AE%E5%A4%8D%E7%A5%9E%E7%BB%8F%E7%9A%84%E6%9C%BA%E5%88%B6\"><\/span><strong>\u795e\u7ecf\u5e72\u7ec6\u80de\u4fee\u590d\u795e\u7ecf\u7684\u673a\u5236<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>\u795e\u7ecf\u5e72\u7ec6\u80de\u79fb\u690d\u6cbb\u7597\u8111\u51fa\u8840\u7684\u673a\u5236\u590d\u6742\uff0c\u4e3b\u8981\u53ef\u5f52\u7eb3\u4e3a\u4ee5\u4e0b\u4e09\u4e2a\u65b9\u9762\uff1a<\/p>\n<h3><span class=\"ez-toc-section\" id=\"1%E3%80%81%E5%85%8D%E7%96%AB%E8%B0%83%E8%8A%82%E4%B8%8E%E7%82%8E%E7%97%87%E6%8A%91%E5%88%B6\"><\/span>1\u3001\u514d\u75ab\u8c03\u8282\u4e0e\u708e\u75c7\u6291\u5236<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u79fb\u690d\u7684\u795e\u7ecf\u5e72\u7ec6\u80de\u53d1\u6325\u6cbb\u7597\u4f5c\u7528\u7684\u6838\u5fc3\u673a\u5236\u4e4b\u4e00\u662f\u5176\u5f3a\u5927\u7684\u514d\u75ab\u8c03\u8282\u80fd\u529b\u3002\u57fa\u7840\u7814\u7a76\u8868\u660e\uff0c\u5b83\u4eec\u80fd\u591f\u663e\u8457\u6291\u5236\u8111\u51fa\u8840\u540e\u8fc7\u5ea6\u6fc0\u6d3b\u7684\u5c0f\u80f6\u8d28\u7ec6\u80de\/\u5de8\u566c\u7ec6\u80de\uff0c\u51cf\u5c11\u4fc3\u708e\u7ec6\u80de\u56e0\u5b50\uff08\u5982IL-1\u03b2\u3001IL-6\u3001TNF-\u03b1\uff09\u7684\u91ca\u653e\uff0c\u5e76\u963b\u65adNF-\u03baB\u548cJAK-STAT\u7b49\u5173\u952e\u708e\u75c7\u4fe1\u53f7\u901a\u8def\uff0c\u4ece\u800c\u51cf\u8f7b\u795e\u7ecf\u708e\u75c7\u3001\u964d\u4f4e\u8840\u8111\u5c4f\u969c\u7834\u574f\u548c\u7ee7\u53d1\u6027\u635f\u4f24\u3002\u6b64\u5916\uff0c\u7ecf\u8fc7\u57fa\u56e0\u6539\u9020\u8fc7\u8868\u8fbe\u7279\u5b9a\u795e\u7ecf\u8425\u517b\u56e0\u5b50\uff08\u5982BDNF\uff09\u7684\u795e\u7ecf\u5e72\u7ec6\u80de\uff0c\u53ef\u8fdb\u4e00\u6b65\u5f3a\u5316\u8fd9\u79cd\u6297\u708e\u6548\u5e94\uff0c\u5e76\u540c\u65f6\u523a\u6fc0\u5185\u6e90\u6027\u795e\u7ecf\u5e72\u7ec6\u80de\u7684\u589e\u6b96\u4e0e\u5206\u5316\u3002<\/p>\n<h3><span class=\"ez-toc-section\" id=\"2%E3%80%81%E7%A5%9E%E7%BB%8F%E5%85%83%E6%9B%BF%E4%BB%A3%E4%B8%8E%E7%A5%9E%E7%BB%8F%E8%90%A5%E5%85%BB%E6%94%AF%E6%8C%81\"><\/span>2\u3001\u795e\u7ecf\u5143\u66ff\u4ee3\u4e0e\u795e\u7ecf\u8425\u517b\u652f\u6301<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u795e\u7ecf\u5e72\u7ec6\u80de\u5177\u5907\u5206\u5316\u4e3a\u6210\u719f\u795e\u7ecf\u5143\u548c\u80f6\u8d28\u7ec6\u80de\u7684\u6f5c\u80fd\u3002\u79fb\u690d\u540e\uff0c\u90e8\u5206\u7ec6\u80de\u80fd\u5728\u5bbf\u4e3b\u8111\u5185\u5206\u5316\u4e3a\u8868\u8fbeNeuN\u3001MAP2\u7b49\u795e\u7ecf\u5143\u6807\u5fd7\u7269\u7684\u7ec6\u80de\uff0c\u5e76\u4e0e\u5bbf\u4e3b\u795e\u7ecf\u5143\u5f62\u6210\u7a81\u89e6\u8fde\u63a5\uff0c\u76f4\u63a5\u66ff\u4ee3\u4e22\u5931\u7684\u795e\u7ecf\u7ec6\u80de\u3002\u7136\u800c\uff0c\u66f4\u591a\u7684\u8bc1\u636e\u8868\u660e\uff0c\u79fb\u690d\u7ec6\u80de\u7684\u529f\u80fd\u6539\u5584\u4f5c\u7528\u53ef\u80fd\u66f4\u591a\u5730\u6765\u6e90\u4e8e\u5176\u5206\u6ccc\u7684\u591a\u79cd\u795e\u7ecf\u8425\u517b\u56e0\u5b50\uff08\u5982BDNF\u3001GDNF\u3001NGF\uff09\u3002\u8fd9\u4e9b\u56e0\u5b50\u4e3a\u53d7\u635f\u7684\u5bbf\u4e3b\u795e\u7ecf\u5143\u548c\u5185\u76ae\u7ec6\u80de\u63d0\u4f9b\u8425\u517b\u652f\u6301\uff0c\u589e\u5f3a\u5185\u6e90\u6027\u795e\u7ecf\u53d1\u751f\u3001\u7a81\u89e6\u53ef\u5851\u6027\u548c\u8f74\u7a81\u518d\u751f\uff0c\u521b\u9020\u6709\u5229\u4e8e\u4fee\u590d\u7684\u5fae\u73af\u5883\u3002<\/p>\n<h3><span class=\"ez-toc-section\" id=\"3%E3%80%81%E4%BF%83%E8%BF%9B%E8%A1%80%E7%AE%A1%E7%94%9F%E6%88%90%E4%B8%8E%E8%A1%80%E8%84%91%E5%B1%8F%E9%9A%9C%E4%BF%AE%E5%A4%8D\"><\/span>3\u3001\u4fc3\u8fdb\u8840\u7ba1\u751f\u6210\u4e0e\u8840\u8111\u5c4f\u969c\u4fee\u590d<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u795e\u7ecf\u5e72\u7ec6\u80de\u901a\u8fc7\u5206\u6ccc\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\uff08VEGF\uff09\u3001\u8840\u7ba1\u751f\u6210\u7d201\uff08Ang1\uff09\u7b49\u4fc3<span class=\"\">\u8840\u7ba1\u751f\u6210\u56e0\u5b50<\/span>\uff0c\u4fc3\u8fdb\u635f\u4f24\u533a\u57df\u7684\u65b0\u751f\u8840\u7ba1\u5f62\u6210\uff0c\u589e\u52a0\u5fae\u8840\u7ba1\u5bc6\u5ea6\u3002\u8fd9\u4e0d\u4ec5\u6709\u52a9\u4e8e\u6539\u5584\u5c40\u90e8\u8840\u6d41\u704c\u6ce8\u548c\u8425\u517b\u4f9b\u5e94\uff0c\u8fd8\u6709\u52a9\u4e8e\u91cd\u5efa\u5b8c\u6574\u7684\u795e\u7ecf\u8840\u7ba1\u5355\u5143\u3002\u540c\u65f6\uff0c\u5b83\u4eec\u8fd8\u80fd\u4e0a\u8c03\u8840\u8111\u5c4f\u969c\u5185\u76ae\u7ec6\u80de\u95f4\u7684\u7d27\u5bc6\u8fde\u63a5\u86cb\u767d\uff08\u5982claudin-5, occludin\uff09\u7684\u8868\u8fbe\uff0c\u589e\u5f3a\u8840\u8111\u5c4f\u969c\u5b8c\u6574\u6027\uff0c\u51cf\u8f7b\u8840\u7ba1\u6e90\u6027\u8111\u6c34\u80bf\u3002\u9700\u8981\u6ce8\u610f\u7684\u662f\uff0c\u5728\u6025\u6027\u671f\uff0c\u8fc7\u5f3a\u7684VEGF\u4fe1\u53f7\u53ef\u80fd\u52a0\u5267\u65e9\u671f\u6c34\u80bf\uff0c\u56e0\u6b64\u4f18\u5316\u6cbb\u7597\u65f6\u673a\u81f3\u5173\u91cd\u8981\u3002<\/p>\n<p>\u4ee5\u4e0a\u4e09\u91cd\u673a\u5236\u2014\u2014\u201c\u514d\u75ab\u8c03\u8282\u201d\u3001\u201c\u66ff\u4ee3\u4e0e\u8425\u517b\u201d\u3001\u201c\u4fc3\u8840\u7ba1\u751f\u6210\u201d\u2014\u2014\u5171\u540c\u6784\u6210\u4e86\u795e\u7ecf\u5e72\u7ec6\u80de\u6cbb\u7597\u8111\u51fa\u8840\u7684\u591a\u7ef4\u4fee\u590d\u7f51\u7edc\uff08\u56fe2\uff09\u3002<\/p>\n<section>\n<div id=\"attachment_20786\" style=\"width: 979px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-20786\" class=\"wp-image-20786 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/fphar-16-1660614-g002.jpg\" alt=\"\" width=\"969\" height=\"378\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/fphar-16-1660614-g002.jpg 969w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/fphar-16-1660614-g002-300x117.jpg 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/fphar-16-1660614-g002-768x300.jpg 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/fphar-16-1660614-g002-18x7.jpg 18w\" sizes=\"(max-width: 969px) 100vw, 969px\" \/><p id=\"caption-attachment-20786\" class=\"wp-caption-text\">\u56fe2\uff1a\u5e72\u7ec6\u80de\u548cNSC\u5728ICH\u4e2d\u7684\u6cbb\u7597\u673a\u5236\uff1a\u9610\u660e\u4e86\u5176\u4fdd\u62a4\u4f5c\u7528\uff0c\u5305\u62ec\u4fee\u590d\u3001\u66ff\u4ee3\u3001\u795e\u7ecf\u8425\u517b\u652f\u6301\u3001\u6297\u51cb\u4ea1\u3001\u6297\u708e\u3001\u8840\u7ba1\u518d\u751f\u3001\u795e\u7ecf\u53d1\u751f\u3001\u514d\u75ab\u8c03\u8282\u3001\u795e\u7ecf\u4fee\u590d\u3001\u5206\u5316\u4e3a\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\/\u795e\u7ecf\u5143\/\u5c11\u7a81\u80f6\u8d28\u7ec6\u80de\u4ee5\u53ca\u5bbf\u4e3b\u7ec4\u7ec7\u6574\u5408\u2014\u2014\u6700\u7ec8\u589e\u5f3a\u7ec4\u7ec7\u4fee\u590d\u548c\u795e\u7ecf\u529f\u80fd\u6062\u590d\u3002<\/p><\/div>\n<\/section>\n<h2><span class=\"ez-toc-section\" id=\"%E7%A5%9E%E7%BB%8F%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E8%84%91%E5%87%BA%E8%A1%80%E7%9A%84%E4%B8%B4%E5%BA%8A%E8%AF%95%E9%AA%8C\"><\/span><strong>\u795e\u7ecf\u5e72\u7ec6\u80de\u6cbb\u7597\u8111\u51fa\u8840\u7684\u4e34\u5e8a\u8bd5\u9a8c<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>\u5e72\u7ec6\u80de\u79fb\u690d\u5728\u5352\u4e2d\u6cbb\u7597\u4e2d\u5c55\u73b0\u51fa\u5de8\u5927\u6f5c\u529b\uff0c\u4f46\u73b0\u6709\u7814\u7a76\u4e3b\u8981\u96c6\u4e2d\u5728\u7f3a\u8840\u6027\u5352\u4e2d\uff0c\u9488\u5bf9\u8111\u51fa\u8840\u7684\u4e34\u5e8a\u8bd5\u9a8c\u6570\u91cf\u6709\u9650\u3002\u6839\u636e\u7ec6\u80de\u7c7b\u578b\u548c\u6280\u672f\u4ee3\u9645\uff0c\u795e\u7ecf\u518d\u751f\u7597\u6cd5\u53ef\u5927\u81f4\u5206\u4e3a\u4e09\u4ee3\uff1a<\/p>\n<section data-role=\"list\">\n<section data-role=\"list\">\n<ul 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class=\"list-paddingleft-1\">\n<li>\u7b2c\u4e09\u4ee3\uff1a\u5bf9\u4e0a\u8ff0\u5e72\u7ec6\u80de\u8fdb\u884c\u5de5\u7a0b\u5316\u6539\u9020\uff08\u5982\u57fa\u56e0\u4fee\u9970\uff09\uff0c\u4f5c\u4e3a\u4f18\u5316\u6cbb\u7597\u7684\u836f\u7269\u9012\u9001\u8f7d\u4f53\u6216\u589e\u5f3a\u5176\u7279\u5b9a\u529f\u80fd\u3002<\/li>\n<\/ul>\n<\/section>\n<\/section>\n<\/section>\n<p data-spm-anchor-id=\"5176.28103460.0.i10.96a07551JYuH8h\">\u5728ClinicalTrials.gov\u4e0a\u6ce8\u518c\u7684\u5173\u4e8e\u51fa\u8840\u6027\u5352\u4e2d\u7684\u5e72\u7ec6\u80de\u79fb\u690d\u8bd5\u9a8c\u4ec5\u6709\u516d\u9879\uff1a\u4e24\u9879\u5df2\u5b8c\u6210\uff0c\u4e24\u9879\u6b63\u5728\u8fdb\u884c\uff0c\u8fd8\u6709\u4e24\u9879\u7ed3\u679c\u672a\u62a5\u544a\u3002<\/p>\n<p data-spm-anchor-id=\"5176.28103460.0.i10.96a07551JYuH8h\">2018\u5e74\uff0c\u97e9\u56fd\u7684\u4e00\u9879I\u671f\u8bd5\u9a8c\u8868\u660e\uff0c\u5bf9\u4e8e\u65e9\u4ea7\u513f\u4e25\u91cd\u8111\u5ba4\u5185\u51fa\u8840\uff0cMSC\u79fb\u690d\u5728\u67d0\u4e9b\u60c5\u51b5\u4e0b\u51cf\u5c11\u4e86\u5ba4\u5468\u635f\u4f24\uff0c\u65e0\u6b7b\u4ea1\u6216\u4e25\u91cd\u4e0d\u826f\u53cd\u5e94\uff0c\u663e\u793a\u4e86\u5176\u5b89\u5168\u6027\u548c\u53ef\u884c\u6027\u3002<\/p>\n<section>\n<div id=\"attachment_20783\" style=\"width: 985px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-20783\" class=\"wp-image-20783 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-05_141118_869.png\" alt=\"\" width=\"975\" height=\"364\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-05_141118_869.png 975w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-05_141118_869-300x112.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-05_141118_869-768x287.png 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-05_141118_869-18x7.png 18w\" sizes=\"(max-width: 975px) 100vw, 975px\" \/><p id=\"caption-attachment-20783\" class=\"wp-caption-text\">\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6cbb\u7597\u65e9\u4ea7\u513f\u4e25\u91cd\u8111\u5ba4\u5185\u51fa\u8840\uff1aI\u671f\u5242\u91cf\u9012\u589e\u4e34\u5e8a\u8bd5\u9a8c<\/p><\/div>\n<\/section>\n<\/section>\n<section data-role=\"list\" data-pm-slice=\"4 4 [&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;outer&quot;,&quot;label&quot;:&quot;edit by 135editor&quot;,&quot;data-pm-slice&quot;:&quot;0 0 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aria-describedby=\"caption-attachment-20782\" class=\"wp-image-20782 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-05_141326_773.png\" alt=\"\" width=\"1289\" height=\"465\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-05_141326_773.png 1289w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-05_141326_773-300x108.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-05_141326_773-1024x369.png 1024w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-05_141326_773-768x277.png 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-05_141326_773-18x6.png 18w\" sizes=\"(max-width: 1289px) 100vw, 1289px\" \/><p id=\"caption-attachment-20782\" class=\"wp-caption-text\">\u7ec6\u80de\u7597\u6cd5\u6cbb\u7597\u8111\u51fa\u8840\uff1a\u4e94\u5e74\u968f\u8bbf\u62a5\u544a<\/p><\/div>\n<\/section>\n<p data-spm-anchor-id=\"5176.28103460.0.i10.96a07551JYuH8h\">2017\u5e74\uff0cTsang\u7b49\u7684\u81ea\u4f53\u9aa8\u9ad3\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u7597\u6cd5\u6cbb\u7597\u6162\u6027\u5352\u4e2d\u7684I\/II\u671f\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\u663e\u793a\uff0c\u81ea\u4f53\u9aa8\u9ad3MSC\u79fb\u690d\u76f8\u6bd4\u5b89\u6170\u5242\u6539\u5584\u4e86\u795e\u7ecf\u529f\u80fd\u6062\u590d\u3002<\/p>\n<section>\n<div id=\"attachment_20781\" style=\"width: 975px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-20781\" class=\"wp-image-20781 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-05_141611_284.png\" alt=\"\" width=\"965\" height=\"437\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-05_141611_284.png 965w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-05_141611_284-300x136.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-05_141611_284-768x348.png 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-05_141611_284-18x8.png 18w\" sizes=\"(max-width: 965px) 100vw, 965px\" \/><p id=\"caption-attachment-20781\" class=\"wp-caption-text\">\u81ea\u4f53\u9aa8\u9ad3\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u7597\u6cd5\u6cbb\u7597\u6162\u6027\u5352\u4e2d\u7684I\/II\u671f\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c<\/p><\/div>\n<\/section>\n<p data-spm-anchor-id=\"5176.28103460.0.i10.96a07551JYuH8h\">\u76f8\u53cd\uff0c\u4e2d\u56fd\u4e34\u5e8a\u8bd5\u9a8c\u6ce8\u518c\u4e2d\u5fc3\uff08www.chictr.org.cn\uff09\u5217\u51fa\u4e8616\u9879NSC\u8bd5\u9a8c\uff0c\u5927\u90e8\u5206\u9488\u5bf9\u7f3a\u8840\u6027\u5352\u4e2d\uff0c\u5305\u62ec\u5916\u6ccc\u4f53\u7597\u6cd5\u3001\u8111\u762b\u3001\u5352\u4e2d\u540e\u9057\u75c7\u548c\u810a\u9ad3\u635f\u4f24\uff0c\u4f5c\u4e3a\u5355\u4e2d\u5fc3\u6216\u591a\u4e2d\u5fc3\u7814\u7a76\u8fdb\u884c\u3002\u5e72\u7ec6\u80de\u901a\u5e38\u6765\u6e90\u4e8e\u6613\u83b7\u53d6\u7684\u8110\u5e26\u6216\u9aa8\u9ad3\uff0c\u5f80\u5f80\u5728\u8f83\u665a\u9636\u6bb5\uff08ICH\u540e\u6570\u5468\u81f3\u4e00\u5e74\u591a\uff09\u800c\u975e\u6025\u6027\u671f\u7ed9\u836f\uff0c\u8fd9\u53cd\u6620\u4e86\u521d\u671f\u751f\u547d\u6551\u63f4\u63aa\u65bd\u7684\u4f18\u5148\u7ea7\u3002\uff08\u89c1\u88682\u7684\u5173\u952e\u4e34\u5e8a\u8bd5\u9a8c\u603b\u7ed3\uff09\u3002<\/p>\n<section>\n<div id=\"attachment_20785\" style=\"width: 1155px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-20785\" class=\"wp-image-20785 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/fphar-16-1660614-t003.jpg\" alt=\"\" width=\"1145\" height=\"426\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/fphar-16-1660614-t003.jpg 1145w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/fphar-16-1660614-t003-300x112.jpg 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/fphar-16-1660614-t003-1024x381.jpg 1024w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/fphar-16-1660614-t003-768x286.jpg 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/fphar-16-1660614-t003-18x7.jpg 18w\" sizes=\"(max-width: 1145px) 100vw, 1145px\" \/><p id=\"caption-attachment-20785\" class=\"wp-caption-text\">\u88682\uff1a\u8111\u51fa\u8840\u5e72\u7ec6\u80de\u6cbb\u7597\u5173\u952e\u4e34\u5e8a\u8bd5\u9a8c\u603b\u7ed3\u3002<\/p><\/div>\n<\/section>\n<p data-spm-anchor-id=\"5176.28103460.0.i10.96a07551JYuH8h\">\u603b\u4f53\u800c\u8a00\uff0c\u80da\u80ce\u5e72\u7ec6\u80de\u548c\u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de\u867d\u5206\u5316\u6f5c\u80fd\u5f3a\uff0c\u4f46\u5206\u522b\u9762\u4e34\u4f26\u7406\u3001\u514d\u75ab\u539f\u6027\u548c\u81f4\u7624\u6027\u6311\u6218\uff1b\u795e\u7ecf\u5e72\u7ec6\u80de\u4fee\u590d\u529f\u80fd\u660e\u786e\u4f46\u83b7\u53d6\u56f0\u96be\uff1b\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u5219\u56e0\u6613\u5f97\u6027\u548c\u826f\u597d\u7684\u5b89\u5168\u6027\u88ab\u5e7f\u6cdb\u7814\u7a76\u3002<\/p>\n<p 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size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/fphar-16-1660614-g003.jpg\" alt=\"\" width=\"969\" height=\"509\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/fphar-16-1660614-g003.jpg 969w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/fphar-16-1660614-g003-300x158.jpg 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/fphar-16-1660614-g003-768x403.jpg 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/fphar-16-1660614-g003-18x9.jpg 18w\" sizes=\"(max-width: 969px) 100vw, 969px\" \/><p id=\"caption-attachment-20784\" class=\"wp-caption-text\">\u56fe3\uff1a\u7528\u4e8e\u6cbb\u7597ICH\u7684\u5e72\u7ec6\u80de\u7c7b\u578b\uff1a\u8be5\u56fe\u663e\u793a\u4e86\u7528\u4e8e\u6cbb\u7597ICH\uff08\u8111\u5b9e\u8d28\u51fa\u8840\u3001\u8111\u5ba4\u5185\u51fa\u8840[IVH]\u548c\u86db\u7f51\u819c\u4e0b\u8154\u51fa\u8840[SAH]\uff09\u7684\u5e72\u7ec6\u80de\u7c7b\u578b\uff0c\u5305\u62ec 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class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u795e\u7ecf\u5e72\u7ec6\u80de\u79fb\u690d\u4e3a\u81ea\u53d1\u6027\u8111\u51fa\u8840\u7684\u6cbb\u7597\u5e26\u6765\u4e86\u65b0\u5e0c\u671b\u3002\u4e34\u5e8a\u524d\u7814\u7a76\u8bc1\u5b9e\u5176\u80fd\u901a\u8fc7\u591a\u91cd\u673a\u5236\u4fc3\u8fdb\u795e\u7ecf\u529f\u80fd\u6062\u590d\u3002\u5c3d\u7ba1\u5185\u6e90\u6027\u795e\u7ecf\u5e72\u7ec6\u80de\u5b89\u5168\u6027\u9ad8\uff0c\u4f46\u53d7\u9650\u4e8e\u5176\u6570\u91cf\u4e0e\u8fc1\u79fb\u6548\u7387\uff0c\u5916\u6e90\u6027\u79fb\u690d\u4ecd\u662f\u5f53\u524d\u4e3b\u6d41\u7b56\u7565\u3002\u901a\u8fc7\u751f\u957f\u56e0\u5b50\u7ec4\u5408\uff08\u5982EGF\u4e0ebFGF\uff09\u53ef\u5728\u4f53\u5916\u5b9e\u73b0\u7a33\u5b9a\u3001\u5927\u89c4\u6a21\u7684\u795e\u7ecf\u5e72\u7ec6\u80de\u6269\u589e\u3002<\/p>\n<p>\u6b64\u5916\uff0c\u4e34\u5e8a\u63a2\u7d22\u5df2\u5f00\u59cb\uff0c\u4f8b\u5982\u8840\u80bf\u6e05\u9664\u672f\u8054\u5408\u795e\u7ecf\u5e72\u7ec6\u80de\u79fb\u690d\u5df2\u663e\u793a\u51fa\u534f\u540c\u589e\u6548\u7684\u6f5c\u529b\u3002\u5c3d\u7ba1\u4e34\u5e8a\u524d\u7814\u7a76\u7684\u6210\u529f\u63a8\u52a8\u4e86\u4e34\u5e8a\u8bd5\u9a8c\u7684\u6269\u5c55\u2014\u2014\u4e3b\u8981\u9488\u5bf9\u7f3a\u8840\u6027\u5352\u4e2d\u2014\u2014\u4f46\u4ecd\u9700\u5f00\u5c55\u66f4\u591a\u8bd5\u9a8c\u6765\u8bc1\u5b9eNSCs\u5728\u8111\u51fa\u8840\uff08ICH\uff09\u4e2d\u7684\u7597\u6548\u3002<\/p>\n<h3><span class=\"ez-toc-section\" id=\"%E9%9D%A2%E4%B8%B4%E6%8C%91%E6%88%98\"><\/span>\u9762\u4e34\u6311\u6218<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u795e\u7ecf\u5e72\u7ec6\u80de\u6cbb\u7597\u4ecd\u9762\u4e34\u673a\u5236\u3001\u5b89\u5168\u6027\u4e0e\u8f6c\u5316\u7b49\u591a\u7ef4\u6311\u6218\u3002\u5176\u8be6\u7ec6\u7684\u5206\u5b50\u673a\u5236\u548c\u6700\u4f73\u6cbb\u7597\u65f6\u95f4\u7a97\u5c1a\u672a\u5b8c\u5168\u660e\u786e\uff0c\u4e14\u73b0\u6709\u52a8\u7269\u6a21\u578b\u96be\u4ee5\u5b8c\u5168\u6a21\u62df\u4eba\u8111\u51fa\u8840\u7684\u590d\u6742\u75c5\u7406\u8fdb\u7a0b\u3002<\/p>\n<p>\u5b89\u5168\u6027\u65b9\u9762\uff0c\u514d\u75ab\u6392\u65a5\uff08\u5c24\u5176\u540c\u79cd\u5f02\u4f53\u79fb\u690d\uff09\u548c\u81f4\u7624\u98ce\u9669\uff08\u5c24\u5176\u662f\u591a\u80fd\u5e72\u7ec6\u80de\u6765\u6e90\uff09\u662f\u4e3b\u8981\u5173\u5207\u70b9\uff0c\u9700\u8981\u501f\u52a9\u57fa\u56e0\u7f16\u8f91\u3001\u4e25\u683c\u7684\u8d28\u91cf\u63a7\u5236\u548c\u957f\u671f\u968f\u8bbf\u6765\u76d1\u63a7\u3002<\/p>\n<p>\u4f26\u7406\u4e0a\uff0c\u80da\u80ce\u5e72\u7ec6\u80de\u6765\u6e90\u7684\u4e89\u8bae\u6301\u7eed\u5b58\u5728\u3002\u6b64\u5916\uff0c\u7b26\u5408\u4e34\u5e8a\u7ea7\u6807\u51c6\u7684\u5927\u89c4\u6a21\u3001\u6807\u51c6\u5316\u7ec6\u80de\u751f\u4ea7\u3001\u50a8\u5b58\u4e0e\u8fd0\u8f93\u4f53\u7cfb\uff0c\u4ee5\u53ca\u76f8\u5e94\u7684\u76d1\u7ba1\u6cd5\u89c4\u548c\u652f\u4ed8\u4f53\u7cfb\uff0c\u90fd\u662f\u5b9e\u73b0\u5e7f\u6cdb\u4e34\u5e8a\u5e94\u7528\u5fc5\u987b\u514b\u670d\u7684\u74f6\u9888\u3002<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%E7%BB%93%E8%AE%BA%E4%B8%8E%E5%B1%95%E6%9C%9B\"><\/span><strong>\u7ed3\u8bba\u4e0e\u5c55\u671b<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<section>\n<section>\u5f53\u524d\uff0c\u795e\u7ecf\u5e72\u7ec6\u80de\u79fb\u690d\u6cbb\u7597\u8111\u51fa\u8840\u4f5c\u4e3a\u4e00\u79cd\u6781\u5177\u524d\u666f\u7684\u795e\u7ecf\u4fee\u590d\u7b56\u7565\uff0c\u6b63\u5904\u5728\u4ece\u57fa\u7840\u7814\u7a76\u5411\u4e34\u5e8a\u8f6c\u5316\u8fc7\u6e21\u7684\u5173\u952e\u9636\u6bb5\u3002\u5927\u91cf\u4e34\u5e8a\u524d\u7814\u7a76\u8bc1\u5b9e\u4e86\u5176\u5728\u7ec6\u80de\u66ff\u4ee3\u3001\u514d\u75ab\u8c03\u8282\u548c\u4fc3\u8fdb\u8840\u7ba1\u751f\u6210\u7b49\u65b9\u9762\u7684\u6cbb\u7597\u6f5c\u529b\u3002\u7136\u800c\uff0c\u5c06\u5176\u8f6c\u5316\u4e3a\u5e38\u89c4\u4e34\u5e8a\u7597\u6cd5\u4ecd\u9762\u4e34\u6839\u672c\u6027\u6311\u6218\uff0c\u5305\u62ec\u6700\u4f73\u79fb\u690d\u65f6\u673a\u3001\u7ec6\u80de\u5242\u91cf\u3001\u6765\u6e90\u6807\u51c6\u5316\u4ee5\u53ca\u957f\u671f\u5b89\u5168\u6027\u7684\u786e\u8bc1\u3002\u503c\u5f97\u5173\u6ce8\u7684\u662f\uff0c\u8f6c\u5316\u8fdb\u7a0b\u5df2\u7ecf\u542f\u52a8\uff0c\u4f8b\u5982\u6211\u56fd\u5df2\u6b63\u5f0f\u6279\u51c6\u5e76\u542f\u52a8\u4e86\u201c\u4eba\u8110\u5e26\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u79fb\u690d\u6cbb\u7597\u4e9a\u6025\u6027\u671f\u8111\u51fa\u8840\u7684\u4e34\u5e8a\u7814\u7a76\u201d\u7b49\u56fd\u5bb6\u7ea7\u5907\u6848\u9879\u76ee\uff0c\u6807\u5fd7\u7740\u4e25\u8c28\u7684\u4e34\u5e8a\u63a2\u7d22\u6b63\u5728\u5c55\u5f00\u3002\u540c\u65f6\uff0c\u884c\u4e1a\u6807\u51c6\u5316\u5efa\u8bbe\u4e5f\u5df2\u8d77\u6b65\uff0c\u65e8\u5728\u4e3a\u672a\u6765\u7684\u4e34\u5e8a\u5e94\u7528\u5efa\u7acb\u89c4\u8303\u3002<\/p>\n<p>\u5c55\u671b\u672a\u6765\uff0c\u8be5\u9886\u57df\u7684\u53d1\u5c55\u5c06\u4e3b\u8981\u56f4\u7ed5\u4e34\u5e8a\u8f6c\u5316\u548c\u6280\u672f\u521b\u65b0\u4e24\u4e2a\u6838\u5fc3\u65b9\u5411\u3002<\/p>\n<section data-role=\"list\">\n<section data-role=\"list\">\n<ul class=\"list-paddingleft-1\">\n<li>\u5728\u4e34\u5e8a\u8f6c\u5316\u5c42\u9762\uff0c\u9996\u8981\u4efb\u52a1\u662f\u63a8\u8fdb\u8bbe\u8ba1\u4e25\u8c28\u3001\u89c4\u6a21\u5408\u7406\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u4ee5\u83b7\u53d6\u786e\u51ff\u7684\u4eba\u4f53\u5b89\u5168\u6027\u4e0e\u6709\u6548\u6027\u6570\u636e\uff0c\u5e76\u5efa\u7acb\u4ece\u7ec6\u80de\u5236\u5907\u3001\u8d28\u91cf\u63a7\u5236\u5230\u6cbb\u7597\u65b9\u6848\u7684\u5b8c\u6574\u6807\u51c6\u4f53\u7cfb\u3002<\/li>\n<\/ul>\n<\/section>\n<section data-role=\"list\">\n<ul class=\"list-paddingleft-1\">\n<li>\u5728\u6280\u672f\u521b\u65b0\u5c42\u9762\uff0c\u7814\u7a76\u91cd\u70b9\u5c06\u805a\u7126\u4e8e\u63d0\u5347\u6cbb\u7597\u6548\u679c\u548c\u5b89\u5168\u6027\uff0c\u4f8b\u5982\u5f00\u53d1\u57fa\u4e8e\u78c1\u6027\u7eb3\u7c73\u9897\u7c92\u7684\u201c\u9776\u5411\u9012\u9001\u7cfb\u7edf\u201d\u4ee5\u63d0\u9ad8\u7ec6\u80de\u5f52\u5de2\u6548\u7387\uff0c\u63a2\u7d22\u7ec6\u80de\u9884\u5904\u7406\uff08\u5982\u7f3a\u6c27\u9884\u9002\u5e94\uff09\u6216\u57fa\u56e0\u4fee\u9970\u7b56\u7565\u4ee5\u589e\u5f3a\u5176\u5b58\u6d3b\u4e0e\u4fee\u590d\u529f\u80fd\uff0c\u5e76\u7efc\u5408\u5229\u7528\u4eba\u5de5\u667a\u80fd\u8f85\u52a9\u51b3\u7b56\u548c3D\u7c7b\u5668\u5b98\u6a21\u578b\u7b49\u65b0\u6280\u672f\u6765\u4f18\u5316\u6cbb\u7597\u65b9\u6848\u53ca\u8fdb\u884c\u673a\u5236\u7814\u7a76\u3002<\/li>\n<\/ul>\n<\/section>\n<\/section>\n<p>\u968f\u7740\u591a\u5b66\u79d1\u4ea4\u53c9\u5408\u4f5c\u7684\u6df1\u5165\u4ee5\u53ca\u8f6c\u5316\u533b\u5b66\u7684\u6301\u7eed\u52aa\u529b\uff0c\u795e\u7ecf\u5e72\u7ec6\u80de\u7597\u6cd5\u6709\u671b\u5728\u672a\u6765\u4e94\u5230\u5341\u5e74\u5185\uff0c\u4e3a\u8111\u51fa\u8840\u60a3\u8005\u63d0\u4f9b\u4e00\u79cd\u8d85\u8d8a\u5f53\u524d\u5bf9\u75c7\u652f\u6301\u3001\u5177\u6709\u771f\u6b63\u4fee\u590d\u4ef7\u503c\u7684\u65b0\u578b\u6cbb\u7597\u9009\u62e9\u3002<\/p>\n<\/section>\n<\/section>\n<blockquote><p>References:<\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">[1] <\/span><\/span><span data-pm-slice=\"0 0 []\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">Song P, Shafiq Z, Jiang H, Cai Q (2025) \u795e\u7ecf\u5e72\u7ec6\u80de\u5728\u8111\u51fa\u8840\u6cbb\u7597\u4e2d\u7684\u5e94\u7528\uff1a\u7cfb\u7edf\u8bc4\u4ef7\u3002Front\u00a0 <\/span><\/span><\/span><em><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">. Pharmacol.<\/span><\/span><\/em><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u00a016:1660614\u3002doi: 10.3389\/fphar.2025.1660614<\/span><\/span><\/p>\n<p>Disclaimer: This article is intended only to disseminate scientific knowledge and share industry perspectives, and does not constitute any clinical diagnostic advice! The information published by Hangi Stem Cells is not a substitute for the professional advice of a physician or pharmacist. If you have any questions about copyright or other issues, please feel free to contact me.<\/p><\/blockquote>\n<\/section>","protected":false},"excerpt":{"rendered":"<p>\u8111\u51fa\u8840\uff08ICH\uff09\u662f\u4e00\u79cd\u9ad8\u81f4\u6b7b\u81f4\u6b8b\u7387\u7684\u8111\u8840\u7ba1\u75be\u75c5\uff0c\u73b0\u6709\u6cbb\u7597\u624b\u6bb5\u5bf9\u795e\u7ecf\u529f\u80fd\u7f3a\u635f\u7684\u6539\u5584\u6709\u9650\u3002\u795e\u7ecf\u5e72\u7ec6\u80de\uff08NSC\uff09\u79fb\u690d [&hellip;]<\/p>","protected":false},"author":1,"featured_media":20779,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[73],"tags":[165,251,164],"_links":{"self":[{"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/posts\/20778"}],"collection":[{"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/comments?post=20778"}],"version-history":[{"count":2,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/posts\/20778\/revisions"}],"predecessor-version":[{"id":20791,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/posts\/20778\/revisions\/20791"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/media\/20779"}],"wp:attachment":[{"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/media?parent=20778"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/categories?post=20778"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/tags?post=20778"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}