{"id":21148,"date":"2025-12-26T16:00:33","date_gmt":"2025-12-26T08:00:33","guid":{"rendered":"https:\/\/www.hjtdsm.cn\/?p=21148"},"modified":"2025-12-26T16:03:13","modified_gmt":"2025-12-26T08:03:13","slug":"https-www-hjtdsm-cn-stem-cells-psc-21148-html","status":"publish","type":"post","link":"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/psc\/21148.html","title":{"rendered":"\u8840\u6db2\u76f4\u63a5\u751f\u6210\u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de\uff0c\u4e34\u5e8a\u8f6c\u5316\u969c\u788d\u88ab\u653b\u514b\uff0c\u5317\u4eac\u5927\u5b66\u9093\u5b8f\u9b41\u56e2\u961f\u91cd\u5927\u7a81\u7834\uff01"},"content":{"rendered":"<p data-pm-slice=\"0 0 []\">\u5728\u518d\u751f\u533b\u5b66\u9886\u57df\uff0c<a href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/psc\/19896.html\/\" target=\"_blank\" rel=\"noopener\">\u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de\uff08iPS \u7ec6\u80de\uff09<\/a>\u7684\u51fa\u73b0\u582a\u79f0\u9769\u547d\u6027\u7a81\u7834 \uff0c\u8fd9\u79cd\u80fd\u81ea\u6211\u66f4\u65b0\u3001\u5e76\u5206\u5316\u4e3a\u4eba\u4f53\u5404\u7c7b\u529f\u80fd\u7ec6\u80de\u7684 \u201c\u4e07\u80fd\u7ec6\u80de\u201d\uff0c\u4e3a\u91cd\u5927\u75be\u75c5\u7684\u4e2a\u6027\u5316\u6cbb\u7597\u5f00\u8f9f\u4e86\u65b0\u8def\u5f84\u3002<\/p>\n<p data-pm-slice=\"0 0 []\">\u76ee\u524d\uff0c\u57fa\u4e8e iPS \u7ec6\u80de\u7684\u7ec6\u80de\u7597\u6cd5\u5df2\u5728\u591a\u9879\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u5c55\u73b0\u51fa\u826f\u597d\u524d\u666f\uff0c\u4f46\u4f20\u7edf\u6280\u672f\u957f\u671f\u53d7\u9650\u4e8e\u6210\u672c\u9ad8\u3001\u6d41\u7a0b\u590d\u6742\u3001\u5b89\u5168\u98ce\u9669\u7b49\u95ee\u9898\uff0c\u96be\u4ee5\u5b9e\u73b0\u5e7f\u6cdb\u4e34\u5e8a\u5e94\u7528\u3002<\/p>\n<section class=\"mp_profile_iframe_wrp\"><\/section>\n<section>\n<div id=\"attachment_21150\" style=\"width: 775px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-21150\" class=\"wp-image-21150 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-26_154648_768.png\" alt=\"\u5317\u4eac\u5927\u5b66\u9093\u5b8f\u9b41\u56e2\u961f\u91cd\u5927\u7a81\u7834\uff01\u8840\u6db2\u76f4\u63a5\u751f\u6210\u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de\uff0c\u4e34\u5e8a\u8f6c\u5316\u969c\u788d\u88ab\u653b\u514b\" width=\"765\" height=\"486\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-26_154648_768.png 765w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-26_154648_768-300x191.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-26_154648_768-18x12.png 18w\" sizes=\"(max-width: 765px) 100vw, 765px\" \/><p id=\"caption-attachment-21150\" class=\"wp-caption-text\">\u5229\u7528\u5316\u5b66\u91cd\u7f16\u7a0b\u6280\u672f\u4ece\u5916\u5468\u8840\u4e2d\u9ad8\u6548\u751f\u6210\u5177\u6709\u4e34\u5e8a\u5e94\u7528\u4ef7\u503c\u7684\u4eba\u7c7b\u591a\u80fd\u5e72\u7ec6\u80de<\/p><\/div>\n<\/section>\n<p data-pm-slice=\"0 0 []\">\u8fd1\u65e5\uff0c<a href=\"https:\/\/www.nature.com\/articles\/s41421-025-00852-7#Fig1\" target=\"_blank\" rel=\"nofollow noopener\">\u5317\u4eac\u5927\u5b66\u9093\u5b8f\u9b41\u56e2\u961f\u7b49\u8054\u5408\u7814\u7a76\u673a\u6784\u5728\u300a<span class=\"\">Cell Discovery<\/span>\u300b\u4e0a\u53d1\u8868\u7684\u4e00\u9879\u91cd\u78c5\u7814\u7a76<\/a>\uff0c\u6210\u529f\u7834\u89e3\u4e86\u8fd9\u4e00\u96be\u9898\uff1a\u4ed6\u4eec\u5efa\u7acb\u4e86\u4e00\u5957\u65e0\u8840\u6e05\u3001\u4e34\u5e8a\u9002\u7528\u7684\u5316\u5b66\u91cd\u7f16\u7a0b\u7cfb\u7edf\uff0c\u53ef\u76f4\u63a5\u4ece\u4eba\u4f53\u5916\u5468\u8840\u4e2d\u9ad8\u6548\u751f\u6210\u9ad8\u8d28\u91cf\u7684\u4eba\u7c7b\u5316\u5b66\u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de\uff08<span class=\"\">hCiPS \u7ec6\u80de<\/span>\uff09\uff0c\u4e3a\u5e72\u7ec6\u80de\u7597\u6cd5\u7684\u89c4\u6a21\u5316\u4e34\u5e8a\u8f6c\u5316\u5960\u5b9a\u4e86\u5173\u952e\u57fa\u7840\u3002<\/p>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_79_2 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewbox=\"0 0 24 24\" version=\"1.2\" baseprofile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/psc\/21148.html\/#01%E3%80%81%E7%8E%B0%E7%8A%B6%EF%BC%9A%E5%B9%B2%E7%BB%86%E8%83%9E%E7%96%97%E6%B3%95%E7%9A%84%E6%9B%99%E5%85%89%E4%B8%8E%E7%93%B6%E9%A2%88\" >01\u3001\u73b0\u72b6\uff1a\u5e72\u7ec6\u80de\u7597\u6cd5\u7684\u66d9\u5149\u4e0e\u74f6\u9888<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/psc\/21148.html\/#02%E3%80%81%E8%AF%B1%E5%AF%BC%E5%A4%9A%E8%83%BD%E5%B9%B2%E7%BB%86%E8%83%9E%E6%8A%80%E6%9C%AF%E7%9A%84%E7%AA%81%E7%A0%B4%EF%BC%9A%E4%BB%8E%E2%80%9C%E5%BE%AE%E9%87%8F%E8%A1%80%E6%B6%B2%E2%80%9D%E5%88%B0%E2%80%9C%E6%97%A0%E9%99%90%E6%BD%9C%E8%83%BD%E2%80%9D\" >02\u3001\u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de\u6280\u672f\u7684\u7a81\u7834\uff1a\u4ece\u201c\u5fae\u91cf\u8840\u6db2\u201d\u5230\u201c\u65e0\u9650\u6f5c\u80fd\u201d<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/psc\/21148.html\/#03%E3%80%81%E4%B8%A5%E6%A0%BC%E9%AA%8C%E8%AF%81%EF%BC%9A%E7%BB%86%E8%83%9E%E8%B4%A8%E9%87%8F%E7%AC%A6%E5%90%88%E4%B8%B4%E5%BA%8A%E6%A0%87%E5%87%86\" >03\u3001\u4e25\u683c\u9a8c\u8bc1\uff1a\u7ec6\u80de\u8d28\u91cf\u7b26\u5408\u4e34\u5e8a\u6807\u51c6<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/psc\/21148.html\/#04%E3%80%81%E4%B8%B4%E5%BA%8A%E5%89%8D%E6%99%AF%EF%BC%9A%E4%B8%AA%E6%80%A7%E5%8C%96%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E8%BF%88%E5%85%A5%E5%AE%9E%E7%94%A8%E5%8C%96%E9%98%B6%E6%AE%B5\" >04\u3001\u4e34\u5e8a\u524d\u666f\uff1a\u4e2a\u6027\u5316\u7ec6\u80de\u6cbb\u7597\u8fc8\u5165\u5b9e\u7528\u5316\u9636\u6bb5<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/psc\/21148.html\/#05%E3%80%81%E6%9C%AA%E6%9D%A5%EF%BC%9A%E9%80%9A%E5%BE%80%E4%B8%AA%E6%80%A7%E5%8C%96%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E7%9A%84%E2%80%9C%E9%AB%98%E9%80%9F%E5%85%AC%E8%B7%AF%E2%80%9D\" >05\u3001\u672a\u6765\uff1a\u901a\u5f80\u4e2a\u6027\u5316\u7ec6\u80de\u6cbb\u7597\u7684\u201c\u9ad8\u901f\u516c\u8def\u201d<\/a><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"01%E3%80%81%E7%8E%B0%E7%8A%B6%EF%BC%9A%E5%B9%B2%E7%BB%86%E8%83%9E%E7%96%97%E6%B3%95%E7%9A%84%E6%9B%99%E5%85%89%E4%B8%8E%E7%93%B6%E9%A2%88\"><\/span>01\u3001\u73b0\u72b6\uff1a\u5e72\u7ec6\u80de\u7597\u6cd5\u7684\u66d9\u5149\u4e0e\u74f6\u9888<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p class=\"ds-markdown-paragraph\">\u518d\u751f\u533b\u5b66\u9886\u57df\u66fe\u56e0\u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de\uff08iPS\u7ec6\u80de\uff09\u7684\u53d1\u73b0\u800c\u8fce\u6765\u9769\u547d\u3002\u8fd9\u79cd\u7ec6\u80de\u80fd\u591f<strong>\u65e0\u9650\u589e\u6b96\uff0c\u5e76\u80fd\u5206\u5316\u6210\u4eba\u4f53\u5185\u51e0\u4e4e\u4efb\u4f55\u7c7b\u578b\u7684\u7ec6\u80de<\/strong>\uff0c\u4e3a\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\u3001\u7cd6\u5c3f\u75c5\u3001\u5fc3\u808c\u6897\u6b7b\u7b49\u91cd\u5927\u75be\u75c5\u5e26\u6765\u4e86\u524d\u6240\u672a\u6709\u7684\u5e0c\u671b\u3002<\/p>\n<p class=\"ds-markdown-paragraph\">\u57fa\u4e8e\u60a3\u8005\u81ea\u8eab\u7ec6\u80de\u5236\u5907\u7684iPS\u7ec6\u80de\uff0c\u7406\u8bba\u4e0a\u53ef\u4ee5\u907f\u514d\u514d\u75ab\u6392\u65a5\uff0c\u5b9e\u73b0\u201c\u79c1\u4eba\u8ba2\u5236\u201d\u7684\u7ec6\u80de\u4fee\u590d\u3002\u7136\u800c\uff0c\u7406\u60f3\u5f88\u4e30\u6ee1\uff0c\u73b0\u5b9e\u5374\u5145\u6ee1\u6311\u6218\u3002\u76ee\u524d\u4e3b\u6d41\u7684iPS\u7ec6\u80de\u5236\u5907\u65b9\u6cd5\u4f9d\u8d56\u5411\u7ec6\u80de\u5185\u5bfc\u5165\u7279\u5b9a\u7684\u201c\u91cd\u7f16\u7a0b\u57fa\u56e0\u201d\uff08\u8f6c\u5f55\u56e0\u5b50\uff09\uff0c\u5982OCT4\u3001SOX2\u7b49\u3002\u8fd9\u79cd\u65b9\u6cd5\u5b58\u5728<strong>\u6210\u672c\u9ad8\u6602\u3001\u8017\u65f6\u6f2b\u957f\u3001\u6548\u7387\u4f4e\u4e0b<\/strong>\uff0c\u4e14\u75c5\u6bd2\u8f7d\u4f53\u6216\u5916\u6e90\u57fa\u56e0\u53ef\u80fd\u968f\u673a\u63d2\u5165\u57fa\u56e0\u7ec4\uff0c\u5e26\u6765\u6f5c\u5728\u7684\u81f4\u764c\u98ce\u9669\u3002\u4e34\u5e8a\u5e94\u7528\u8981\u6c42\u7ec6\u80de\u4ea7\u54c1\u5fc5\u987b<strong>\u5b89\u5168\u3001\u7eaf\u51c0\u3001\u53ef\u6807\u51c6\u5316\u751f\u4ea7<\/strong>\uff0c\u4f20\u7edf\u65b9\u6cd5\u5728\u8fd9\u4e9b\u65b9\u9762\u77ed\u677f\u660e\u663e\u3002<\/p>\n<p class=\"ds-markdown-paragraph\">2013\u5e74\uff0c\u4e2d\u56fd\u79d1\u5b66\u5bb6\u56e2\u961f\u53e6\u8f9f\u8e4a\u5f84\uff0c\u5728\u56fd\u9645\u4e0a\u7387\u5148\u5efa\u7acb\u4e86<strong>\u5b8c\u5168\u4f7f\u7528\u5c0f\u5206\u5b50\u5316\u5408\u7269\u7684\u201c\u5316\u5b66\u91cd\u7f16\u7a0b\u201d\u6280\u672f<\/strong>\uff0c\u6210\u529f\u5c06\u5c0f\u9f20\u4f53\u7ec6\u80de\u201c\u53d8\u56de\u201d\u591a\u80fd\u5e72\u7ec6\u80de\u30022022\u5e74\uff0c\u8be5\u56e2\u961f\u53c8\u5c06\u8fd9\u4e00\u6280\u672f\u6210\u529f\u5e94\u7528\u4e8e\u4eba\u7c7b\u4f53\u7ec6\u80de\uff0c\u8bde\u751f\u4e86<strong>\u4eba\u7c7b\u5316\u5b66\u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de\uff08hCiPS\u7ec6\u80de\uff09<\/strong>The<span dir=\"auto\">\u91cd\u8981\u7684\u662f\uff0c\u6211\u4eec\u540e\u7eed\u7684\u4e34\u5e8a\u7ed3\u679c\u8868\u660e\uff0c\u5c06\u81ea\u4f53hCiPS\u7ec6\u80de\u884d\u751f\u7684\u80f0\u5c9b\u79fb\u690d\u52301\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u4f53\u5185\u53ef\u4f7f\u5176\u6301\u7eed\u6446\u8131\u80f0\u5c9b\u7d20\u4f9d\u8d56<\/span><span dir=\"auto\">\uff0c\u8fd9\u51f8\u663e\u4e86\u60a3\u8005\u7279\u5f02\u6027hCiPS\u7ec6\u80de\u5728\u6cbb\u7597\u91cd\u5927\u75be\u75c5\u65b9\u9762\u7684\u6cbb\u7597\u6f5c\u529b\u3002\u8fd9\u4e9b\u8fdb\u5c55\u8868\u660e\uff0c\u5316\u5b66\u91cd\u7f16\u7a0b\u662f\u4e00\u79cd\u6781\u5177\u524d\u666f\u7684\u5e72\u7ec6\u80de\u751f\u4ea7\u7b56\u7565\uff0c\u4e5f\u662f\u4e2a\u6027\u5316\u7ec6\u80de\u4e34\u5e8a\u5e94\u7528\u7684\u5f3a\u5927\u5e73\u53f0\u3002<\/span><\/p>\n<p>\u800c\u6b64\u6b21\u7814\u7a76\uff0c\u6b63\u662f\u8be5\u56e2\u961f\u5728\u5316\u5b66\u91cd\u7f16\u7a0b\u6280\u672f\u4e0a\u7684\u53c8\u4e00\u91cd\u5927\u7a81\u7834\uff0c\u805a\u7126\u4e8e\u89e3\u51b3\u4e34\u5e8a\u9002\u7528\u7684\u8840\u6db2\u7ec6\u80de\u91cd\u7f16\u7a0b\u96be\u9898\u3002<\/p>\n<div id=\"attachment_21149\" style=\"width: 1985px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-21149\" class=\"wp-image-21149 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/\u5fae\u4fe1\u56fe\u7247_2025-12-26_154710_001.png\" alt=\"\" width=\"1975\" height=\"2077\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/\u5fae\u4fe1\u56fe\u7247_2025-12-26_154710_001.png 1975w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/\u5fae\u4fe1\u56fe\u7247_2025-12-26_154710_001-285x300.png 285w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/\u5fae\u4fe1\u56fe\u7247_2025-12-26_154710_001-974x1024.png 974w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/\u5fae\u4fe1\u56fe\u7247_2025-12-26_154710_001-768x808.png 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/\u5fae\u4fe1\u56fe\u7247_2025-12-26_154710_001-1461x1536.png 1461w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/\u5fae\u4fe1\u56fe\u7247_2025-12-26_154710_001-1947x2048.png 1947w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/\u5fae\u4fe1\u56fe\u7247_2025-12-26_154710_001-11x12.png 11w\" sizes=\"(max-width: 1975px) 100vw, 1975px\" \/><p id=\"caption-attachment-21149\" class=\"wp-caption-text\">\u56fe1\uff1a\u5efa\u7acb\u7b26\u5408\u4e34\u5e8a\u89c4\u8303\u7684\u8840\u7ec6\u80de\u91cd\u7f16\u7a0b\u65b9\u6848\u3002<\/p><\/div>\n<h2><span class=\"ez-toc-section\" id=\"02%E3%80%81%E8%AF%B1%E5%AF%BC%E5%A4%9A%E8%83%BD%E5%B9%B2%E7%BB%86%E8%83%9E%E6%8A%80%E6%9C%AF%E7%9A%84%E7%AA%81%E7%A0%B4%EF%BC%9A%E4%BB%8E%E2%80%9C%E5%BE%AE%E9%87%8F%E8%A1%80%E6%B6%B2%E2%80%9D%E5%88%B0%E2%80%9C%E6%97%A0%E9%99%90%E6%BD%9C%E8%83%BD%E2%80%9D\"><\/span>02\u3001\u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de\u6280\u672f\u7684\u7a81\u7834\uff1a\u4ece\u201c\u5fae\u91cf\u8840\u6db2\u201d\u5230\u201c\u65e0\u9650\u6f5c\u80fd\u201d<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p class=\"ds-markdown-paragraph\">\u5c3d\u7ba1\u53d6\u5f97\u4e86\u521d\u6b65\u6210\u529f\uff0c\u4f46\u65e9\u671f\u7684hCiPS\u7ec6\u80de\u591a\u6765\u6e90\u4e8e\u8102\u80aa\u6216\u76ae\u80a4\u7ec4\u7ec7\uff0c<strong>\u83b7\u53d6\u8fc7\u7a0b\u6709\u521b\uff0c\u9650\u5236\u4e86\u5176\u5e7f\u6cdb\u5e94\u7528<\/strong>The<\/p>\n<p class=\"ds-markdown-paragraph\">\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u8840\u6db2\uff0c\u5c24\u5176\u662f\u5916\u5468\u8840\uff0c\u56e0\u5176<strong>\u6613\u83b7\u53d6\u3001\u5fae\u521b\u3001\u6765\u6e90\u4e30\u5bcc<\/strong>\uff0c\u6210\u4e3a\u5236\u5907\u60a3\u8005\u7279\u5f02\u6027\u5e72\u7ec6\u80de\u7684\u6700\u7406\u60f3\u8d77\u70b9\u3002\u5168\u7403\u6d77\u91cf\u7684\u8840\u6db2\u6837\u672c\u5e93\uff0c\u66f4\u662f\u4e3a\u8fd9\u9879\u6280\u672f\u63d0\u4f9b\u4e86\u5de8\u5927\u7684\u8d44\u6e90\u5b9d\u5e93\u3002<\/p>\n<p class=\"ds-markdown-paragraph\"><strong>\u7136\u800c\uff0c\u5982\u4f55\u7528\u65e0\u5316\u5b66\u6210\u5206\u660e\u786e\u7684\u65e0\u8840\u6e05\u4f53\u7cfb\uff0c\u9ad8\u6548\u5730\u5c06\u8840\u6db2\u7ec6\u80de\u91cd\u7f16\u7a0b\uff0c\u662f\u4e00\u4e2a\u60ac\u800c\u672a\u51b3\u7684\u96be\u9898\u3002<\/strong><\/p>\n<p class=\"ds-markdown-paragraph\">\u7814\u7a76\u56e2\u961f\u9996\u5148\u9762\u4e34\u4e00\u4e2a\u5173\u952e\u969c\u788d\uff1a\u53bb\u9664\u4e34\u5e8a\u7981\u7528\u7684\u52a8\u7269\u8840\u6e05\uff08\u5982\u80ce\u725b\u8840\u6e05\uff09\u540e\uff0c\u8840\u6db2\u7ec6\u80de\u5b8c\u5168\u5931\u53bb\u4e86\u542f\u52a8\u91cd\u7f16\u7a0b\u7684\u80fd\u529b\u3002<\/p>\n<p class=\"ds-markdown-paragraph\"><strong>\u4ed6\u4eec\u901a\u8fc7\u7cfb\u7edf\u6027\u7b5b\u9009\uff0c\u627e\u5230\u4e86B27\u4e0eKSR\u8fd9\u4e24\u79cd\u6210\u5206\u7684\u7ec4\u5408\uff0c\u6210\u529f\u66ff\u4ee3\u4e86\u8840\u6e05\u529f\u80fd\u3002<\/strong><\/p>\n<p class=\"ds-markdown-paragraph\">\u7d27\u63a5\u7740\uff0c\u56e2\u961f\u901a\u8fc7\u9ad8\u901a\u91cf\u7b5b\u9009\uff0c\u53d1\u73b0\u4e86\u4e00\u4e2a\u540d\u4e3a\u00a0<strong>\u201cPY-60\u201d\u7684\u5c0f\u5206\u5b50\u5316\u5408\u7269<\/strong>\uff0c\u5b83\u80fd\u663e\u8457\u4fc3\u8fdb\u8840\u6db2\u7ec6\u80de\u5728\u91cd\u7f16\u7a0b\u65e9\u671f\u5411\u4e0a\u76ae\u6837\u7ec6\u80de\u8f6c\u53d8\uff0c\u8fd9\u662f\u542f\u52a8\u6574\u4e2a\u7a0b\u5e8f\u7684\u5173\u952e\u201c\u5f00\u5173\u201d\u3002<\/p>\n<p class=\"ds-markdown-paragraph\">\u7ecf\u8fc7\u5bf9\u57f9\u517b\u57fa\u6210\u5206\u548c\u5c0f\u5206\u5b50\u201c\u9e21\u5c3e\u9152\u201d\u914d\u65b9\u7684\u53cd\u590d\u4f18\u5316\uff0c\u4e00\u5957<strong>\u6210\u5206\u5b8c\u5168\u660e\u786e\u3001\u9ad8\u6548\u7a33\u5b9a\u7684\u65e0\u8840\u6e05\u5316\u5b66\u91cd\u7f16\u7a0b\u65b9\u6848<\/strong>\u7ec8\u4e8e\u8bde\u751f\u3002<\/p>\n<p class=\"ds-markdown-paragraph\">\u8fd9\u5957\u65b9\u6848\u6709\u591a\u5f3a\u5927\uff1f<\/p>\n<ul>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>\u9ad8\u6548\u7387<\/strong>\uff1a\u4ece\u5355\u5b54\u8840\u6837\u4e2d\u80fd\u83b7\u5f97\u8d85\u8fc7100\u4e2a\u9ad8\u8d28\u91cfhCiPS\u7ec6\u80de\u96c6\u843d\u3002<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>\u901f\u5ea6\u5feb<\/strong>\uff1a\u6700\u5feb\u4ec5\u970018-24\u5929\u5373\u53ef\u5b8c\u6210\u91cd\u7f16\u7a0b\u3002<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>\u6750\u6599\u5fae\u521b<\/strong>\uff1a\u4e0d\u4ec5\u53ef\u7528\u5e38\u89c4\u9759\u8109\u8840\uff0c\u751a\u81f3<strong>50-100\u5fae\u5347\u7684\u5fae\u91cf\u9759\u8109\u8840\u6216\u7b80\u5355\u7684\u6307\u5c16\u91c7\u8840<\/strong>\uff0c\u5c31\u8db3\u4ee5\u6210\u529f\u5236\u5907\u51fa\u5e72\u7ec6\u80de\u3002<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>\u666e\u9002\u6027\u5f3a<\/strong>\uff1a\u5728\u6765\u81ea14\u4f4d\u4e0d\u540c\u4f9b\u8005\u7684\u8840\u6db2\u6837\u672c\u4e2d\u5747\u83b7\u6210\u529f\uff0c\u8bc1\u660e\u4e86\u5176<strong>\u5353\u8d8a\u7684\u7a33\u5b9a\u6027\u548c\u53ef\u91cd\u590d\u6027<\/strong>The<\/p>\n<\/li>\n<\/ul>\n<p class=\"ds-markdown-paragraph\">\u7ecf\u4e25\u683c\u68c0\u6d4b\uff0c\u8fd9\u4e9b\u7531\u8840\u6db2\u201c\u53d8\u8eab\u201d\u800c\u6765\u7684hCiPS\u7ec6\u80de<strong>\u67d3\u8272\u4f53\u6b63\u5e38\uff0c\u9ad8\u8868\u8fbe\u591a\u80fd\u6027\u6838\u5fc3\u86cb\u767d\uff0c\u5728\u57fa\u56e0\u8868\u8fbe\u8c31\u4e0a\u4e0e\u4eba\u7c7b\u80da\u80ce\u5e72\u7ec6\u80de\u9ad8\u5ea6\u76f8\u4f3c<\/strong>\uff0c\u5e76\u5177\u5907\u5206\u5316\u4e3a\u4eba\u4f53\u6240\u6709\u4e09\u5927\u80da\u5c42\u7ec4\u7ec7\u7684\u80fd\u529b\uff0c\u5b8c\u5168\u7b26\u5408\u591a\u80fd\u5e72\u7ec6\u80de\u7684\u6240\u6709\u6807\u51c6\u3002<\/p>\n<h2><span class=\"ez-toc-section\" id=\"03%E3%80%81%E4%B8%A5%E6%A0%BC%E9%AA%8C%E8%AF%81%EF%BC%9A%E7%BB%86%E8%83%9E%E8%B4%A8%E9%87%8F%E7%AC%A6%E5%90%88%E4%B8%B4%E5%BA%8A%E6%A0%87%E5%87%86\"><\/span>03\u3001\u4e25\u683c\u9a8c\u8bc1\uff1a\u7ec6\u80de\u8d28\u91cf\u7b26\u5408\u4e34\u5e8a\u6807\u51c6<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>\u4e00\u9879\u6280\u672f\u80fd\u5426\u7528\u4e8e\u4e34\u5e8a\uff0c\u5173\u952e\u5728\u4e8e\u5176\u751f\u6210\u7ec6\u80de\u7684\u5b89\u5168\u6027\u548c\u529f\u80fd\u6027\u3002\u7814\u7a76\u56e2\u961f\u5bf9\u65e0\u8840\u6e05\u7cfb\u7edf\u751f\u6210\u7684 hCiPS \u7ec6\u80de\u8fdb\u884c\u4e86\u5168\u9762\u7684\u8868\u5f81\u9a8c\u8bc1\uff0c\u7ed3\u679c\u663e\u793a\u8fd9\u4e9b\u7ec6\u80de\u5b8c\u5168\u7b26\u5408\u4e34\u5e8a\u7ea7\u5e72\u7ec6\u80de\u7684\u6807\u51c6\uff1a<\/p>\n<p>\u5728\u5f62\u6001\u548c\u9057\u4f20\u7a33\u5b9a\u6027\u4e0a\uff0chCiPS \u7ec6\u80de\u5f62\u6210\u4e86\u8fb9\u754c\u6e05\u6670\u3001\u6838\u4ec1\u660e\u663e\u7684\u7ec6\u80de\u96c6\u843d\uff0c\u4e0e\u4eba\u7c7b\u80da\u80ce\u5e72\u7ec6\u80de\uff08hESCs\uff09\u9ad8\u5ea6\u76f8\u4f3c\uff1b\u67d3\u8272\u4f53\u6838\u578b\u5206\u6790\u8bc1\u5b9e\u7ec6\u80de\u65e0\u67d3\u8272\u4f53\u5f02\u5e38\uff0c\u9057\u4f20\u6307\u7eb9\u56fe\u8c31\u4e5f\u9a8c\u8bc1\u4e86\u8fd9\u4e9b\u7ec6\u80de\u786e\u5b9e\u6765\u6e90\u4e8e\u6350\u8d60\u8005\u81ea\u8eab\u7684\u8840\u6db2\u7ec6\u80de\uff0c\u6392\u9664\u4e86\u4ea4\u53c9\u6c61\u67d3\u7684\u53ef\u80fd\u3002<\/p>\n<p>\u5728\u591a\u80fd\u6027\u65b9\u9762\uff0c\u514d\u75ab\u8367\u5149\u67d3\u8272\u663e\u793a hCiPS \u7ec6\u80de\u540c\u65f6\u8868\u8fbe OCT4\u3001SOX2\u3001NANOG 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