{"id":21165,"date":"2025-12-29T18:12:58","date_gmt":"2025-12-29T10:12:58","guid":{"rendered":"https:\/\/www.hjtdsm.cn\/?p=21165"},"modified":"2025-12-29T18:13:26","modified_gmt":"2025-12-29T10:13:26","slug":"https-www-hjtdsm-cn-stem-cells-stem-cell-therapy-21165-html","status":"publish","type":"post","link":"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/21165.html","title":{"rendered":"\u8111\u5185\u6ce8\u5c04\u201c\u667a\u6167\u79cd\u5b50\u201d\uff1a\u9996\u6b21\u4eba\u4f53\u8bd5\u9a8c\u663e\u793a\uff0c\u65b0\u578b\u5e72\u7ec6\u80de\u6cbb\u7597\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u80fd\u591f\u7ed9\u5e7f\u5927\u60a3\u8005\u5e26\u6765\u8f6c\u673a"},"content":{"rendered":"<blockquote>\n<p class=\"ds-markdown-paragraph\">\u4e00\u9879\u7a81\u7834\u6027\u7684\u4e34\u5e8a\u7814\u7a76\u9996\u6b21\u5c06\u7ecf\u8fc7\u7279\u6b8a\u6fc0\u6d3b\u7684\u8102\u80aa\u5e72\u7ec6\u80de\u76f4\u63a5\u6ce8\u5165\u60a3\u8005\u8111\u5ba4\uff0c\u65e9\u671f\u6570\u636e\u663e\u793a\uff0c\u8fd9\u79cd\u65b0\u578b\u5e72\u7ec6\u80de\u6cbb\u7597\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u7597\u6cd5\u4e0d\u4ec5\u5b89\u5168\uff0c\u8fd8\u80fd\u663e\u8457\u964d\u4f4e\u5173\u952e\u81f4\u75c5\u86cb\u767d\u5e76\u6539\u5584\u8ba4\u77e5\u529f\u80fd\u3002<\/p>\n<\/blockquote>\n<p class=\"ds-markdown-paragraph\">\u8102\u80aa\u62bd\u5438\u672f\u7684\u8fdb\u884c\u6807\u5fd7\u7740\u6cbb\u7597\u5f00\u59cb\uff0c\u533b\u751f\u4ece\u60a3\u8005\u4f53\u5185\u83b7\u53d6\u8102\u80aa\u7ec4\u7ec7\u3002\u968f\u540e\uff0c\u8fd9\u4e9b\u8102\u80aa\u7ec4\u7ec7\u4e2d\u7684\u5e72\u7ec6\u80de\u5728\u5b9e\u9a8c\u5ba4\u4e2d\u88ab\u5206\u79bb\u3001\u6269\u589e\uff0c\u5e76\u901a\u8fc7\u7279\u6b8a\u6280\u672f\u6fc0\u6d3b\u5176\u5173\u952e\u7684 Wnt \u4fe1\u53f7\u901a\u8def\u3002<\/p>\n<p class=\"ds-markdown-paragraph\">\u5b8c\u6210\u5236\u5907\u7684\u7ec6\u80de\uff0c\u901a\u8fc7\u4e00\u4e2a\u9884\u5148\u690d\u5165\u5934\u76ae\u7684\u3001\u540d\u4e3aOmmaya\u50a8\u6db2\u56ca\u7684\u5fae\u578b\u88c5\u7f6e\uff0c\u88ab\u7cbe\u51c6\u8f93\u6ce8\u5230\u60a3\u8005\u8111\u5ba4\u7684\u8111\u810a\u6db2\u4e2d\u3002<\/p>\n<p class=\"ds-markdown-paragraph\">\u8fd9\u662f\u8fd1\u671f\u4e00\u9879\u53d1\u8868\u5728\u9876\u5c16\u533b\u5b66\u671f\u520a\u300a<em>Alzheimer&#8217;s &amp; Dementia<\/em>\u00ae\u300b\u4e0a\u4e00\u7bc7\u9488\u5bf9<a href=\"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz70861_108493\" target=\"_blank\" rel=\"nofollow noopener\">\u8f7b\u5ea6\u81f3\u4e2d\u5ea6\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u60a3\u8005\u7684\u9996\u6b21\u4eba\u4f53 I \u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u7814\u7a76<\/a>\u3002\u622a\u81f3\u6ce8\u5c04\u540e\u6700\u957f55\u5468\u7684\u968f\u8bbf\u671f\u5185\uff0c\u6240\u6709\u63a5\u53d7\u6cbb\u7597\u7684\u60a3\u8005\u5747\u672a\u51fa\u73b0\u4e0e\u7ec6\u80de\u6ce8\u5c04\u76f8\u5173\u7684\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6<sup>[1]<\/sup>The<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-21169 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-29_175131_870.png\" alt=\"\u65b0\u578b\u5e72\u7ec6\u80de\u6cbb\u7597\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u80fd\u591f\u7ed9\u5e7f\u5927\u60a3\u8005\u5e26\u6765\u8f6c\u673a\" width=\"712\" height=\"359\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-29_175131_870.png 712w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-29_175131_870-300x151.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/ScreenShot_2025-12-29_175131_870-18x9.png 18w\" sizes=\"(max-width: 712px) 100vw, 712px\" \/><\/p>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_79_2 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewbox=\"0 0 24 24\" version=\"1.2\" baseprofile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/21165.html\/#%E8%84%91%E5%86%85%E6%B3%A8%E5%B0%84%E2%80%9C%E6%99%BA%E6%85%A7%E7%A7%8D%E5%AD%90%E2%80%9D%EF%BC%9A%E9%A6%96%E6%AC%A1%E4%BA%BA%E4%BD%93%E8%AF%95%E9%AA%8C%E6%98%BE%E7%A4%BA%EF%BC%8C%E6%96%B0%E5%9E%8B%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E9%98%BF%E5%B0%94%E8%8C%A8%E6%B5%B7%E9%BB%98%E7%97%85%E8%83%BD%E5%A4%9F%E7%BB%99%E5%B9%BF%E5%A4%A7%E6%82%A3%E8%80%85%E5%B8%A6%E6%9D%A5%E8%BD%AC%E6%9C%BA\" >\u8111\u5185\u6ce8\u5c04\u201c\u667a\u6167\u79cd\u5b50\u201d\uff1a\u9996\u6b21\u4eba\u4f53\u8bd5\u9a8c\u663e\u793a\uff0c\u65b0\u578b\u5e72\u7ec6\u80de\u6cbb\u7597\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u80fd\u591f\u7ed9\u5e7f\u5927\u60a3\u8005\u5e26\u6765\u8f6c\u673a<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/21165.html\/#01_%E7%A0%94%E7%A9%B6%E8%83%8C%E6%99%AF\" >01 \u7814\u7a76\u80cc\u666f<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/21165.html\/#02_%E4%B8%BA%E4%BB%80%E4%B9%88%E6%98%AF%E5%AE%83%EF%BC%9F\" >02 \u4e3a\u4ec0\u4e48\u662f\u5b83\uff1f<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/21165.html\/#03_%E7%A0%94%E7%A9%B6%E6%96%B9%E6%B3%95\" >03 \u7814\u7a76\u65b9\u6cd5<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/21165.html\/#04_%E7%A0%94%E7%A9%B6%E7%BB%93%E6%9E%9C\" >04 \u7814\u7a76\u7ed3\u679c<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/21165.html\/#05_%E6%9B%99%E5%85%89%E4%B8%8E%E6%8C%91%E6%88%98\" >05 \u66d9\u5149\u4e0e\u6311\u6218<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/21165.html\/#06_%E7%BB%93%E8%AE%BA\" >06 \u7ed3\u8bba<\/a><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"%E8%84%91%E5%86%85%E6%B3%A8%E5%B0%84%E2%80%9C%E6%99%BA%E6%85%A7%E7%A7%8D%E5%AD%90%E2%80%9D%EF%BC%9A%E9%A6%96%E6%AC%A1%E4%BA%BA%E4%BD%93%E8%AF%95%E9%AA%8C%E6%98%BE%E7%A4%BA%EF%BC%8C%E6%96%B0%E5%9E%8B%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E9%98%BF%E5%B0%94%E8%8C%A8%E6%B5%B7%E9%BB%98%E7%97%85%E8%83%BD%E5%A4%9F%E7%BB%99%E5%B9%BF%E5%A4%A7%E6%82%A3%E8%80%85%E5%B8%A6%E6%9D%A5%E8%BD%AC%E6%9C%BA\"><\/span>\u8111\u5185\u6ce8\u5c04\u201c\u667a\u6167\u79cd\u5b50\u201d\uff1a\u9996\u6b21\u4eba\u4f53\u8bd5\u9a8c\u663e\u793a\uff0c\u65b0\u578b\u5e72\u7ec6\u80de\u6cbb\u7597\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u80fd\u591f\u7ed9\u5e7f\u5927\u60a3\u8005\u5e26\u6765\u8f6c\u673a<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<hr \/>\n<h2><span class=\"ez-toc-section\" id=\"01_%E7%A0%94%E7%A9%B6%E8%83%8C%E6%99%AF\"><\/span>01 \u7814\u7a76\u80cc\u666f<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p class=\"ds-markdown-paragraph\">\u5728\u5168\u7403\u8001\u9f84\u5316\u8d8b\u52bf\u4e0b\uff0c<a href=\"https:\/\/www.hjtdsm.cn\/en\/research\/ns\/ad\/20831.html\/\" target=\"_blank\" rel=\"noopener\">senile dementia<\/a>\u5df2\u6210\u4e3a\u6700\u5177\u6311\u6218\u7684\u516c\u5171\u536b\u751f\u95ee\u9898\u4e4b\u4e00\u3002\u4f20\u7edf\u7684\u836f\u7269\u7814\u53d1\u4e3b\u8981\u805a\u7126\u4e8e\u5355\u4e00\u9776\u70b9\uff0c\u4f46AD\u75c5\u56e0\u590d\u6742\uff0c\u6d89\u53ca\u03b2-\u6dc0\u7c89\u6837\u86cb\u767d\u6c89\u79ef\u3001Tau\u86cb\u767d\u8fc7\u5ea6\u78f7\u9178\u5316\u3001\u795e\u7ecf\u708e\u75c7\u7b49\u591a\u91cd\u673a\u5236\u3002<\/p>\n<p class=\"ds-markdown-paragraph\">\u5355\u4e00\u9776\u70b9\u836f\u7269\u5c61\u5c61\u5728\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u6298\u621f\uff0c\u4f7f\u5f97\u5b66\u754c\u5c06\u76ee\u5149\u6295\u5411\u66f4\u5177\u6574\u4f53\u8c03\u8282\u6f5c\u80fd\u7684<strong>\u7ec6\u80de\u7597\u6cd5<\/strong>The<\/p>\n<p class=\"ds-markdown-paragraph\">\u7136\u800c\uff0c\u5c06\u7ec6\u80de\u7597\u6cd5\u5e94\u7528\u4e8e AD \u7684\u6cbb\u7597\uff0c\u5c24\u5176\u662f\u901a\u8fc7\u76f4\u63a5\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u7ed9\u836f\u7684\u65b9\u5f0f\uff0c\u4e34\u5e8a\u7ecf\u9a8c\u51e0\u4e4e\u7a7a\u767d\uff0c\u5176\u5b89\u5168\u6027\u4e0e\u53ef\u884c\u6027\u662f\u6a2a\u4e98\u5728\u7814\u7a76\u8005\u9762\u524d\u7684\u9996\u8981\u95ee\u9898\u3002<\/p>\n<h2><span class=\"ez-toc-section\" id=\"02_%E4%B8%BA%E4%BB%80%E4%B9%88%E6%98%AF%E5%AE%83%EF%BC%9F\"><\/span>02 \u4e3a\u4ec0\u4e48\u662f\u5b83\uff1f<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p class=\"ds-markdown-paragraph\">\u672c\u6b21\u8bd5\u9a8c\u7684\u6838\u5fc3\u2014\u2014\u201cWnt \u6fc0\u6d3b\u7684\u8102\u80aa\u6765\u6e90\u5e72\u7ec6\u80de\u201d\uff0c\u5176\u8bbe\u8ba1\u8574\u542b\u7740\u7cbe\u5bc6\u7684\u79d1\u5b66\u903b\u8f91\u3002\u8102\u80aa\u6765\u6e90\u7684\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6613\u4e8e\u83b7\u53d6\u3001\u6269\u589e\u80fd\u529b\u5f3a\uff0c\u4e14\u5177\u6709\u514d\u75ab\u8c03\u8282\u548c\u5206\u6ccc\u795e\u7ecf\u8425\u517b\u56e0\u5b50\u7684\u6f5c\u80fd\u3002<\/p>\n<p class=\"ds-markdown-paragraph\">(indicates contrast)\u00a0<strong>Wnt \u4fe1\u53f7\u901a\u8def<\/strong>\u00a0\u7684\u6fc0\u6d3b\u662f\u70b9\u775b\u4e4b\u7b14\u3002\u8be5\u901a\u8def\u662f\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u4e2d\u8c03\u63a7\u7ec6\u80de\u5b58\u6d3b\u3001\u7a81\u89e6\u53ef\u5851\u6027\u548c\u795e\u7ecf\u53d1\u751f\u7684\u5173\u952e\u9014\u5f84\u3002\u5728 AD \u60a3\u8005\u5927\u8111\u4e2d\uff0cWnt \u901a\u8def\u529f\u80fd\u5e38\u5e38\u53d7\u635f\u3002<\/p>\n<p class=\"ds-markdown-paragraph\">\u7814\u7a76\u8005\u901a\u8fc7\u4f53\u5916\u9884\u6fc0\u6d3b\uff0c\u76f8\u5f53\u4e8e\u5728\u8f93\u6ce8\u524d\u4e3a\u5e72\u7ec6\u80de\u201c\u8d4b\u80fd\u201d\uff0c\u4f7f\u5176\u80fd\u66f4\u597d\u5730\u9002\u5e94\u75c5\u7406\u6027\u8111\u73af\u5883\uff0c\u5e76\u53ef\u80fd\u66f4\u5f3a\u5730\u53d1\u6325\u4fee\u590d\u4f5c\u7528\u3002<\/p>\n<p class=\"ds-markdown-paragraph\">\u7ed9\u836f\u9014\u5f84\u9009\u62e9\u00a0<strong>\u8111\u5ba4\u5185\u6ce8\u5c04<\/strong>\uff0c\u662f\u5c06\u7ec6\u80de\u76f4\u63a5\u9012\u9001\u81f3\u8111\u810a\u6db2\u5faa\u73af\u7cfb\u7edf\uff0c\u4f7f\u5176\u80fd\u5e7f\u6cdb\u63a5\u89e6\u5927\u8111\u8868\u9762\u548c\u6df1\u90e8\u533a\u57df\uff0c\u7a81\u7834\u4e86\u8840\u8111\u5c4f\u969c\u7684\u9650\u5236\u3002<\/p>\n<h2><span class=\"ez-toc-section\" id=\"03_%E7%A0%94%E7%A9%B6%E6%96%B9%E6%B3%95\"><\/span>03 \u7814\u7a76\u65b9\u6cd5<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p class=\"ds-markdown-paragraph\">\u8fd9\u9879\u7531\u7f8e\u56fd FDA \u6279\u51c6\u7684\u5f00\u653e\u6807\u7b7e I \u671f\u8bd5\u9a8c\uff0c\u9996\u8981\u76ee\u6807\u662f\u8bc4\u4f30\u6cbb\u7597\u7684\u5b89\u5168\u6027\u3002\u7814\u7a76\u91c7\u7528\u4e86\u6807\u51c6\u7684\u5242\u91cf\u9012\u589e\u8bbe\u8ba1\u3002<\/p>\n<p class=\"ds-markdown-paragraph\">\u524d5\u540d\u53d7\u8bd5\u8005\u88ab\u5206\u4e3a\u4e24\u7ec4\uff0c\u5206\u522b\u63a5\u53d7\u4f4e\u5242\u91cf\uff08200\u4e07\u4e2a\u7ec6\u80de\uff09\u548c\u4e2d\u5242\u91cf\uff08500\u4e07\u4e2a\u7ec6\u80de\uff09\u7684\u6cbb\u7597\u3002\u6240\u6709\u60a3\u8005\u5e74\u9f84\u572880\u5c81\u4ee5\u4e0b\uff0c\u5904\u4e8e\u963f\u5c14\u8328\u6d77\u9ed8\u75c5 FAST \u5206\u671f\u7684\u7b2c4\u62165\u671f\u3002<\/p>\n<p class=\"ds-markdown-paragraph\">\u5728\u8ba4\u77e5\u91cf\u8868\u3001\u8111\u810a\u6db2\u751f\u7269\u6807\u5fd7\u7269\u548c\u6dc0\u7c89\u6837\u86cb\u767d PET \u5f71\u50cf\u5b66\u4e0a\u5747\u7b26\u5408 AD \u8bca\u65ad\u6807\u51c6\u3002\u6cbb\u7597\u6d41\u7a0b\u5206\u4e3a\u4e09\u6b65\uff1a\u83b7\u53d6\u8102\u80aa\u5e76\u5236\u5907\u7ec6\u80de\u3001\u624b\u672f\u690d\u5165 Ommaya \u50a8\u6db2\u56ca\u3001\u901a\u8fc7\u8be5\u50a8\u6db2\u56ca\u5355\u6b21\u8f93\u6ce8\u7ec6\u80de\u4ea7\u54c1\u3002<\/p>\n<p class=\"ds-markdown-paragraph\">\u7814\u7a76\u7684\u4e3b\u8981\u7ec8\u70b9\u662f\u6cbb\u7597\u7684\u5b89\u5168\u6027\u3002\u6b21\u8981\u7ec8\u70b9\u5219\u7740\u773c\u4e8e<strong>\u7597\u6548\u63a2\u7d22<\/strong>\uff0c\u5305\u62ec\u8111\u810a\u6db2\u4e2d\u78f7\u9178\u5316 Tau \u86cb\u767d\u548c \u03b2-\u6dc0\u7c89\u6837\u86cb\u767d\u6c34\u5e73\u7684\u964d\u4f4e\uff0c\u4ee5\u53ca ADAS-cog \u548c MMSE \u8ba4\u77e5\u91cf\u8868\u8bc4\u5206\u7684\u6539\u5584\u3002<\/p>\n<h2><span class=\"ez-toc-section\" id=\"04_%E7%A0%94%E7%A9%B6%E7%BB%93%E6%9E%9C\"><\/span>04 \u7814\u7a76\u7ed3\u679c<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p class=\"ds-markdown-paragraph\">\u5b89\u5168\u6027\u6570\u636e\u663e\u793a\u51fa\u4e86\u4ee4\u4eba\u9f13\u821e\u7684\u524d\u666f\u3002\u6240\u6709\u62a5\u544a\u7684\u4e0d\u826f\u4e8b\u4ef6\u5747\u4e0e\u524d\u671f\u7684\u624b\u672f\u64cd\u4f5c\u6709\u5173\uff0c\u4ec5\u4e3a\u8f7b\u5fae\u7684\u7600\u4f24\u548c\u4e0d\u9002\u3002<strong>\u5728\u7ec6\u80de\u4ea7\u54c1\u8f93\u6ce8\u540e\u957f\u8fbe23\u81f355\u5468\u7684\u89c2\u5bdf\u671f\u5185\uff0c\u6ca1\u6709\u53d1\u751f\u4efb\u4f55\u4e0e\u6ce8\u5c04\u76f4\u63a5\u76f8\u5173\u7684\u5934\u75db\u3001\u6076\u5fc3\u6216\u5176\u4ed6\u795e\u7ecf\u7cfb\u7edf\u4e0d\u826f\u4e8b\u4ef6\uff08\u56fe1\uff09<\/strong>The<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-21168 aligncenter\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/alz108493-gra-0001-m.jpg\" alt=\"\" width=\"1000\" height=\"643\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/alz108493-gra-0001-m.jpg 1000w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/alz108493-gra-0001-m-300x193.jpg 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/alz108493-gra-0001-m-768x494.jpg 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/alz108493-gra-0001-m-18x12.jpg 18w\" sizes=\"(max-width: 1000px) 100vw, 1000px\" \/><\/p>\n<p class=\"ds-markdown-paragraph\">\u8fd9\u4e3a\u9996\u4e2a\u5173\u952e\u95ee\u9898\u2014\u2014\u8111\u5ba4\u5185\u6ce8\u5c04\u81ea\u4f53\u6fc0\u6d3b\u5e72\u7ec6\u80de\u7684\u5b89\u5168\u6027\uff0c\u63d0\u4f9b\u4e86\u521d\u6b65\u7684\u80af\u5b9a\u7b54\u6848\u3002<\/p>\n<p class=\"ds-markdown-paragraph\">\u5728\u7597\u6548\u63a2\u7d22\u6027\u6307\u6807\u4e0a\uff0c\u6570\u636e\u5448\u73b0\u51fa\u79ef\u6781\u7684\u4fe1\u53f7\u3002\u6ce8\u5c04\u540e\u7b2c12\u5468\uff0c<strong>80%\u7684\u53d7\u8bd5\u8005\u8111\u810a\u6db2\u4e2d\u78f7\u9178\u5316Tau\u86cb\u767d\u6c34\u5e73\u4ece\u57fa\u7ebf\u4e2d\u4f4d\u657060.2 pg\/ml\u4e0b\u964d\u81f336.8 pg\/ml<\/strong>\uff0c\u8d8b\u5411\u4e8e\u6b63\u5e38\u8303\u56f4\u3002<\/p>\n<p class=\"ds-markdown-paragraph\">\u6dc0\u7c89\u6837\u86cb\u767d PET \u626b\u63cf\u663e\u793a\uff0c<span dir=\"auto\">60%\u7684\u53d7\u8bd5\u8005\u6dc0\u7c89\u6837\u86cb\u767dPET\u626b\u63cf\u767e\u5206\u4f4d\u8bc4\u5206\u7531\u6ce8\u5c04\u524d\u4e2d\u4f4d\u6570137.2\uff08\u8303\u56f4\uff1a55.33-155.47\uff09\u964d\u4f4e\u81f3\u4e2d\u4f4d\u6570100.53\uff08\u8303\u56f4\uff1a55.58-168.1\uff09\uff08\u56fe2\uff09<\/span>\u3002\u66f4\u4e3a\u91cd\u8981\u7684\u662f\u8ba4\u77e5\u529f\u80fd\u7684\u6539\u53d8\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-21167 aligncenter\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/alz108493-gra-0002-m.jpg\" alt=\"\" width=\"1000\" height=\"462\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/alz108493-gra-0002-m.jpg 1000w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/alz108493-gra-0002-m-300x139.jpg 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/alz108493-gra-0002-m-768x355.jpg 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/alz108493-gra-0002-m-18x8.jpg 18w\" sizes=\"(max-width: 1000px) 100vw, 1000px\" \/><\/p>\n<p class=\"ds-markdown-paragraph\">\u5230\u7b2c12\u5468\uff0c80%\u7684\u60a3\u8005\u5728 ADAS-cog \u8bc4\u5206\u4e0a\u663e\u793a\u51fa\u6539\u5584\uff0c\u4e2d\u4f4d\u6570\u4ece53\u5206\u63d0\u5347\u81f338\u5206\uff08\u56fe3\uff09\uff1b60%\u7684\u60a3\u8005 MMSE \u8bc4\u5206\u4ece\u4e2d\u4f4d\u657016\u5206\u63d0\u5347\u81f318\u5206\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-21166 aligncenter\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/alz108493-gra-0003-m.jpg\" alt=\"\" width=\"1000\" height=\"457\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/alz108493-gra-0003-m.jpg 1000w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/alz108493-gra-0003-m-300x137.jpg 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/alz108493-gra-0003-m-768x351.jpg 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/alz108493-gra-0003-m-18x8.jpg 18w\" sizes=\"(max-width: 1000px) 100vw, 1000px\" \/><\/p>\n<h2><span class=\"ez-toc-section\" id=\"05_%E6%9B%99%E5%85%89%E4%B8%8E%E6%8C%91%E6%88%98\"><\/span>05 \u66d9\u5149\u4e0e\u6311\u6218<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p class=\"ds-markdown-paragraph\">\u8fd9\u9879\u201c\u9996\u6b21\u4eba\u4f53\u201d\u8bd5\u9a8c\u7684\u7ed3\u679c\uff0c\u65e0\u7591\u4e3a\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u7ec6\u80de\u6cbb\u7597\u9886\u57df\u6295\u4e0b\u4e86\u4e00\u7f15\u66d9\u5149\u3002\u5b83\u9996\u6b21\u7cfb\u7edf\u5730\u8bc1\u660e\u4e86\uff0c<strong>\u7ecf\u8111\u5ba4\u5185\u9014\u5f84\u9012\u9001\u7279\u5b9a\u7c7b\u578b\u7684\u81ea\u4f53\u5e72\u7ec6\u80de\uff0c\u5728\u77ed\u671f\u5230\u4e2d\u671f\u5185\u5177\u6709\u826f\u597d\u7684\u8010\u53d7\u6027\u548c\u5b89\u5168\u6027<\/strong>The<\/p>\n<p class=\"ds-markdown-paragraph\">\u8fd9\u4e3a\u66f4\u5927\u89c4\u6a21\u7684\u4e34\u5e8a\u8bd5\u9a8c\u626b\u6e05\u4e86\u6700\u521d\u3001\u4e5f\u662f\u6700\u91cd\u8981\u7684\u969c\u788d\u3002<\/p>\n<p class=\"ds-markdown-paragraph\">\u5728\u7597\u6548\u6307\u6807\u4e0a\u770b\u5230\u7684\u751f\u7269\u6807\u5fd7\u7269\u6539\u5584\u548c\u8ba4\u77e5\u8bc4\u5206\u63d0\u5347\u8d8b\u52bf\uff0c\u867d\u7136\u6765\u81ea\u5c0f\u6837\u672c\u7684\u63a2\u7d22\u6027\u5206\u6790\uff0c\u4f46\u4e3a\u201c\u7ec6\u80de\u6cbb\u7597\u53ef\u80fd\u5bf9 AD \u75c5\u7406\u8fc7\u7a0b\u548c\u4e34\u5e8a\u75c7\u72b6\u4ea7\u751f\u79ef\u6781\u5f71\u54cd\u201d\u7684\u5047\u8bf4\u63d0\u4f9b\u4e86\u521d\u6b65\u7684\u4eba\u7c7b\u6570\u636e\u652f\u6301\u3002<\/p>\n<p class=\"ds-markdown-paragraph\">\u7136\u800c\uff0c\u89e3\u8bfb\u8fd9\u4e9b\u7ed3\u679c\u65f6\u5fc5\u987b\u4fdd\u6301\u5ba1\u614e\u7684\u7406\u6027\u3002\u8fd9\u662f\u4e00\u9879<strong>\u6ca1\u6709\u8bbe\u7f6e\u5b89\u6170\u5242\u5bf9\u7167\u7684\u65e9\u671f\u7814\u7a76<\/strong>\uff0c\u6837\u672c\u91cf\u5f88\u5c0f\uff0c\u89c2\u5bdf\u671f\u76f8\u5bf9\u8f83\u77ed\uff0c\u5176\u7ed3\u679c\u4e3b\u8981\u7528\u4e8e\u6307\u5bfc\u540e\u7eed\u7814\u7a76\u8bbe\u8ba1\u3002<\/p>\n<p class=\"ds-markdown-paragraph\">\u6211\u4eec\u65e0\u6cd5\u6392\u9664\u5b89\u6170\u5242\u6548\u5e94\u6216\u75be\u75c5\u81ea\u7136\u6ce2\u52a8\u5bf9\u8ba4\u77e5\u8bc4\u5206\u7684\u5f71\u54cd\u3002AD \u662f\u4e00\u79cd\u6162\u6027\u8fdb\u5c55\u6027\u75be\u75c5\uff0c<strong>\u77ed\u671f\u6539\u5584\u80fd\u5426\u8f6c\u5316\u4e3a\u957f\u671f\u7684\u75c5\u7a0b\u5ef6\u7f13\uff0c\u662f\u66f4\u4e25\u5cfb\u7684\u8003\u9a8c<\/strong>The<\/p>\n<h2><span class=\"ez-toc-section\" id=\"06_%E7%BB%93%E8%AE%BA\"><\/span>06 \u7ed3\u8bba<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p class=\"ds-markdown-paragraph\">\u8fd9\u9879\u5f00\u521b\u6027\u7684 I \u671f\u4e34\u5e8a\u7814\u7a76\uff0c\u6210\u529f\u5730\u5c06\u201cWnt \u6fc0\u6d3b\u7684\u8102\u80aa\u5e72\u7ec6\u80de\u201d\u901a\u8fc7\u8111\u5ba4\u5185\u6ce8\u5c04\u5e94\u7528\u4e8e\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u60a3\u8005\uff0c\u5e76\u5b8c\u6210\u4e86\u521d\u6b65\u7684\u5b89\u5168\u6027\u4e0e\u53ef\u884c\u6027\u9a8c\u8bc1\u3002<\/p>\n<p class=\"ds-markdown-paragraph\">\u65e9\u671f\u6570\u636e\u4e0d\u4ec5\u663e\u793a\u4e86\u826f\u597d\u7684\u8010\u53d7\u6027\uff0c\u66f4\u5728<strong>Tau\u86cb\u767d\u78f7\u9178\u5316\u3001\u03b2-\u6dc0\u7c89\u6837\u86cb\u767d\u6c89\u79ef\u4ee5\u53ca\u8ba4\u77e5\u529f\u80fd<\/strong>\u00a0\u7b49\u591a\u4e2a\u6838\u5fc3\u7ef4\u5ea6\u4e0a\uff0c\u89c2\u5bdf\u5230\u4e86\u4ee4\u4eba\u632f\u594b\u7684\u6539\u5584\u8d8b\u52bf\u3002<\/p>\n<p class=\"ds-markdown-paragraph\">\u5b83\u4e3a\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u8fd9\u79cd\u590d\u6742\u75be\u75c5\u7684\u6cbb\u7597\uff0c\u5f00\u8f9f\u4e86\u4e00\u6761\u5168\u65b0\u7684\u3001\u7740\u773c\u4e8e\u7cfb\u7edf\u8c03\u8282\u800c\u975e\u5355\u4e00\u9776\u70b9\u7684\u5e72\u9884\u8def\u5f84\u3002\u5f53\u7136\uff0c\u4ece\u521d\u6b65\u66d9\u5149\u5230\u786e\u8bc1\u7597\u6548\uff0c\u8fd8\u6709\u6f2b\u957f\u7684\u9053\u8def\u8981\u8d70\u3002<\/p>\n<p class=\"ds-markdown-paragraph\">\u672a\u6765\u9700\u8981\u5f00\u5c55\u8bbe\u8ba1\u66f4\u4e3a\u4e25\u8c28\u7684\u00a0<strong>II \u671f\u968f\u673a\u53cc\u76f2\u5bf9\u7167\u8bd5\u9a8c<\/strong>\uff0c\u5728\u66f4\u5927\u7684\u60a3\u8005\u7fa4\u4f53\u4e2d\u9a8c\u8bc1\u7597\u6548\uff0c\u786e\u5b9a\u6700\u4f73\u6cbb\u7597\u5242\u91cf\u548c\u7597\u7a0b\uff0c\u5e76\u8fdb\u4e00\u6b65\u63a2\u7d22\u5176\u53d1\u6325\u4f5c\u7528\u7684\u7ec6\u80de\u4e0e\u5206\u5b50\u673a\u5236\u3002<\/p>\n<p class=\"ds-markdown-paragraph\">\u8fd9\u9879\u7814\u7a76\u7684\u610f\u4e49\u5728\u4e8e\uff0c\u5b83\u52c7\u6562\u5730\u8fc8\u51fa\u4e86\u4ece\u5b9e\u9a8c\u5ba4\u5230\u4e34\u5e8a\u7684\u5173\u952e\u7b2c\u4e00\u6b65\uff0c\u4e3a\u4e00\u4e2a\u5145\u6ee1\u6311\u6218\u7684\u9886\u57df\u6253\u5f00\u4e86\u4e00\u6247\u5145\u6ee1\u53ef\u80fd\u6027\u7684\u65b0\u5927\u95e8\u3002<\/p>\n<hr \/>\n<p class=\"ds-markdown-paragraph\"><strong>\u540e\u7eed\u7814\u7a76\u7684\u91cd\u70b9\u5c06\u8f6c\u5411\u66f4\u5927\u89c4\u6a21\u7684\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c<\/strong>\uff0c\u4ee5\u786e\u8bc1\u5176\u7597\u6548\uff0c\u5e76\u6df1\u5165\u63a2\u7d22\u5176\u9006\u8f6c\u75be\u75c5\u8fdb\u7a0b\u7684\u957f\u671f\u6f5c\u529b\u4e0e\u5177\u4f53\u673a\u5236\u3002\u5bf9\u4e8e\u6570\u767e\u4e07\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u60a3\u8005\u5bb6\u5ead\u800c\u8a00\uff0c\u6bcf\u4e00\u9879\u5ba1\u614e\u800c\u575a\u5b9e\u7684\u79d1\u5b66\u8fdb\u6b65\uff0c\u90fd\u627f\u8f7d\u7740\u4e00\u4efd\u539a\u91cd\u7684\u5e0c\u671b\u3002<\/p>\n<blockquote><p>\u53c2\u8003\u8d44\u6599\uff1a[1]:https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz70861_108493<\/p><\/blockquote>","protected":false},"excerpt":{"rendered":"<p>\u4e00\u9879\u7a81\u7834\u6027\u7684\u4e34\u5e8a\u7814\u7a76\u9996\u6b21\u5c06\u7ecf\u8fc7\u7279\u6b8a\u6fc0\u6d3b\u7684\u8102\u80aa\u5e72\u7ec6\u80de\u76f4\u63a5\u6ce8\u5165\u60a3\u8005\u8111\u5ba4\uff0c\u65e9\u671f\u6570\u636e\u663e\u793a\uff0c\u8fd9\u79cd\u65b0\u578b\u5e72\u7ec6\u80de\u6cbb\u7597\u963f\u5c14\u8328\u6d77\u9ed8 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