{"id":21174,"date":"2025-12-30T16:21:00","date_gmt":"2025-12-30T08:21:00","guid":{"rendered":"https:\/\/www.hjtdsm.cn\/?p=21174"},"modified":"2025-12-30T16:22:28","modified_gmt":"2025-12-30T08:22:28","slug":"https-www-hjtdsm-cn-stem-cells-stem-cell-therapy-21174-html","status":"publish","type":"post","link":"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/21174.html","title":{"rendered":"\u5e72\u7ec6\u80de\u4e3a\u4ec0\u4e48\u80fd\u591f\u6cbb\u7597\u4e2d\u98ce\uff1f\u51ed\u501f\u7684\u673a\u5236\u539f\u7406\u662f\u4ec0\u4e48\uff1f\u2014\u2014\u7ed3\u5408\u6700\u65b0\u4e34\u5e8a\u8bd5\u9a8c\u6570\u636e\u7684\u7ed3\u679c\u6765\u4e86"},"content":{"rendered":"<section 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id=\"%E5%B9%B2%E7%BB%86%E8%83%9E%E4%B8%BA%E4%BB%80%E4%B9%88%E8%83%BD%E5%A4%9F%E6%B2%BB%E7%96%97%E4%B8%AD%E9%A3%8E%EF%BC%9F%E5%87%AD%E5%80%9F%E7%9A%84%E6%9C%BA%E5%88%B6%E5%8E%9F%E7%90%86%E6%98%AF%E4%BB%80%E4%B9%88%EF%BC%9F%E2%80%94%E2%80%94%E7%BB%93%E5%90%88%E6%9C%80%E6%96%B0%E4%B8%B4%E5%BA%8A%E8%AF%95%E9%AA%8C%E6%95%B0%E6%8D%AE%E7%9A%84%E7%BB%93%E6%9E%9C%E6%9D%A5%E4%BA%86\"><\/span>\u5e72\u7ec6\u80de\u4e3a\u4ec0\u4e48\u80fd\u591f\u6cbb\u7597\u4e2d\u98ce\uff1f\u51ed\u501f\u7684\u673a\u5236\u539f\u7406\u662f\u4ec0\u4e48\uff1f\u2014\u2014\u7ed3\u5408\u6700\u65b0\u4e34\u5e8a\u8bd5\u9a8c\u6570\u636e\u7684\u7ed3\u679c\u6765\u4e86<span class=\"ez-toc-section-end\"><\/span><\/h2><div id=\"ez-toc-container\" class=\"ez-toc-v2_0_79_2 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right 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href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/21174.html\/#02%E3%80%81%E5%8D%92%E4%B8%AD%E6%81%A2%E5%A4%8D%E4%B8%AD%E7%9A%84%E4%BD%9C%E7%94%A8%E6%9C%BA%E5%88%B6%EF%BC%9A%E5%85%A8%E8%83%BD%E5%88%86%E5%8C%96%E4%B8%8E%E5%A4%9A%E6%95%88%E4%BF%AE%E5%A4%8D%E7%9A%84%E7%BB%93%E5%90%88\" >02\u3001\u5352\u4e2d\u6062\u590d\u4e2d\u7684\u4f5c\u7528\u673a\u5236\uff1a\u5168\u80fd\u5206\u5316\u4e0e\u591a\u6548\u4fee\u590d\u7684\u7ed3\u5408<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/21174.html\/#03%E3%80%81%E4%B8%B4%E5%BA%8A%E7%A0%94%E7%A9%B6%E8%BF%9B%E5%B1%95%EF%BC%9A%E4%B8%B4%E5%BA%8A%E5%89%8D%E8%AF%81%E6%8D%AE%E5%85%85%E5%88%86%EF%BC%8C%E5%8D%92%E4%B8%AD%E4%B8%B4%E5%BA%8A%E5%BA%94%E7%94%A8%E6%96%B9%E5%85%B4%E6%9C%AA%E8%89%BE\" 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href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/21174.html\/#04%E3%80%81%E4%B8%AA%E4%BD%93%E5%8C%96%E4%B8%8E%E7%B2%BE%E5%87%86%E5%8C%96%E7%9A%84%E9%80%92%E9%80%81%E7%AD%96%E7%95%A5\" >04\u3001\u4e2a\u4f53\u5316\u4e0e\u7cbe\u51c6\u5316\u7684\u9012\u9001\u7b56\u7565<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-21\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/21174.html\/#%E4%BA%94%E3%80%81%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E4%B8%AD%E9%A3%8E%E7%9A%84%E4%B8%B4%E5%BA%8A%E8%AF%95%E9%AA%8C%E5%8E%86%E5%8F%B2\" >\u4e94\u3001\u5e72\u7ec6\u80de\u6cbb\u7597\u4e2d\u98ce\u7684\u4e34\u5e8a\u8bd5\u9a8c\u5386\u53f2<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-22\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/21174.html\/#%E5%85%AD%E3%80%81%E7%BB%93%E8%AE%BA%E4%B8%8E%E6%9C%AA%E6%9D%A5%E5%B1%95%E6%9C%9B\" 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srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/istockphoto-1927703857-612x612-1.jpg 612w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/istockphoto-1927703857-612x612-1-300x163.jpg 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/istockphoto-1927703857-612x612-1-18x10.jpg 18w\" sizes=\"(max-width: 612px) 100vw, 612px\" \/><\/p>\n<h2><span class=\"ez-toc-section\" id=\"%E4%B8%80%E3%80%81_%E9%97%B4%E5%85%85%E8%B4%A8%E5%B9%B2%E7%BB%86%E8%83%9E%EF%BC%88MSCs%EF%BC%89%EF%BC%9A%E4%BB%A5%E6%97%81%E5%88%86%E6%B3%8C%E4%B8%BA%E6%A0%B8%E5%BF%83%E7%9A%84%E2%80%9C%E5%BE%AE%E7%8E%AF%E5%A2%83%E8%B0%83%E8%8A%82%E8%80%85%E2%80%9D\"><\/span><strong>\u4e00\u3001 \u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09\uff1a\u4ee5\u65c1\u5206\u6ccc\u4e3a\u6838\u5fc3\u7684\u201c\u5fae\u73af\u5883\u8c03\u8282\u8005\u201d<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<h3 data-spm-anchor-id=\"5176.28103460.0.i10.96a07551yM2FXP\"><span class=\"ez-toc-section\" id=\"01%E3%80%81%E8%B5%B7%E6%BA%90%E4%B8%8E%E7%89%B9%E6%80%A7%EF%BC%9A%E5%B9%BF%E6%B3%9B%E7%9A%84%E7%BB%84%E7%BB%87%E6%9D%A5%E6%BA%90%E4%B8%8E%E5%A4%9A%E8%83%BD%E7%89%B9%E6%80%A7\"><\/span>01\u3001\u8d77\u6e90\u4e0e\u7279\u6027\uff1a\u5e7f\u6cdb\u7684\u7ec4\u7ec7\u6765\u6e90\u4e0e\u591a\u80fd\u7279\u6027<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p data-spm-anchor-id=\"5176.28103460.0.i10.96a07551yM2FXP\"><a href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/mscs\/20558.html\/\" target=\"_blank\" rel=\"noopener\">mesenchymal stem cell MSC (in cell biology)<\/a>\u662f\u4e00\u7c7b\u5177\u6709\u81ea\u6211\u66f4\u65b0\u548c\u591a\u5411\u5206\u5316\u6f5c\u80fd\u7684\u6210\u4f53\u5e72\u7ec6\u80de\u3002\u5b83\u4eec\u5e76\u975e\u6e90\u81ea\u5355\u4e00\u8c31\u7cfb\uff0c\u800c\u662f\u5e7f\u6cdb\u5b58\u5728\u4e8e\u591a\u79cd\u7ec4\u7ec7\u7684\u5fae\u8840\u7ba1\u5468\u56f4\uff0c\u88ab\u8ba4\u4e3a\u662f\u5468\u7ec6\u80de\u6216\u5468\u7ec6\u80de\u6837\u7ec6\u80de\u3002<\/p>\n<p>\u5176\u7ecf\u5178\u6765\u6e90\u5305\u62ec\u9aa8\u9ad3\u3001\u8102\u80aa\u7ec4\u7ec7\u3001\u8110\u5e26\u8840\u4ee5\u53ca\u7259\u9ad3\u7b49\u3002\u8fd9\u4e9b\u7ec6\u80de\u5177\u6709\u4f4e\u514d\u75ab\u539f\u6027\u7684\u5173\u952e\u4f18\u52bf\uff0c\u5e76\u80fd\u5206\u5316\u4e3a\u6210\u9aa8\u3001\u6210\u8102\u3001\u6210\u8f6f\u9aa8\u4e43\u81f3\u795e\u7ecf\u8c31\u7cfb\u7b49\u591a\u79cd\u7ec6\u80de\uff0c\u8fd9\u79cd\u591a\u80fd\u6027\u662f\u5176\u5e94\u7528\u4e8e\u518d\u751f\u533b\u5b66\u7684\u7ec6\u80de\u5b66\u57fa\u7840\u3002<\/p>\n<h3><span class=\"ez-toc-section\" id=\"02%E3%80%81%E5%8D%92%E4%B8%AD%E6%81%A2%E5%A4%8D%E4%B8%AD%E7%9A%84%E4%BD%9C%E7%94%A8%E6%9C%BA%E5%88%B6\"><\/span>02\u3001\u5352\u4e2d\u6062\u590d\u4e2d\u7684\u4f5c\u7528\u673a\u5236<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><a href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/20635.html\/\" target=\"_blank\" rel=\"noopener\">\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6cbb\u7597\u7f3a\u8840\u6027\u5352\u4e2d<\/a>\u7684\u6838\u5fc3\u673a\u5236\u5e76\u975e\u76f4\u63a5\u5206\u5316\u4e3a\u795e\u7ecf\u5143\uff0c\u800c\u662f\u901a\u8fc7\u5f3a\u5927\u7684 \u201c\u65c1\u5206\u6ccc\u201d\u4f5c\u7528\u5b9e\u73b0\u7cfb\u7edf\u6027\u4fee\u590d\u3002\u79fb\u690d\u540e\u7684MSCs\u4f1a\u91ca\u653e\u4e00\u4e2a\u590d\u6742\u7684\u751f\u7269\u6d3b\u6027\u56e0\u5b50\u96c6\u5408\uff08\u5373\u201c\u5206\u6ccc\u7ec4\u201d\uff09\uff0c<span dir=\"auto\" data-pm-slice=\"0 0 []\">MSC\u7684\u591a\u65b9\u9762\u6cbb\u7597\u673a\u5236\u603b\u7ed3\u4e8e\u56fe1<\/span><span dir=\"auto\">The<\/span>\u5305\u62ec\uff1a<\/p>\n<section data-role=\"list\">\n<ul class=\"list-paddingleft-1\">\n<li>\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\uff08VEGF\uff09\uff1a\u4fc3\u8fdb\u7f3a\u8840\u533a\u8840\u7ba1\u65b0\u751f\uff0c\u6539\u5584\u8840\u4f9b\u3002<\/li>\n<li>\u8111\u6e90\u6027\u795e\u7ecf\u8425\u517b\u56e0\u5b50\uff08BDNF\uff09\uff1a\u652f\u6301\u795e\u7ecf\u5143\u5b58\u6d3b\uff0c\u589e\u5f3a\u7a81\u89e6\u53ef\u5851\u6027\u3002<\/li>\n<li>\u591a\u79cd\u6297\u708e\u56e0\u5b50\uff08\u5982PGE2\u3001IL-10\uff09\uff1a\u8c03\u8282\u514d\u75ab\u53cd\u5e94\uff0c\u6291\u5236\u6709\u5bb3\u708e\u75c7\uff0c\u4fc3\u8fdb\u5c0f\u80f6\u8d28\u7ec6\u80de\u5411\u4fdd\u62a4\u578b\u8f6c\u5316\u3002<\/li>\n<\/ul>\n<\/section>\n<section>\n<div id=\"attachment_21179\" style=\"width: 610px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-21179\" class=\"wp-image-21179 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/sci3734659-fig-0002-m.jpg\" alt=\"\" width=\"600\" height=\"497\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/sci3734659-fig-0002-m.jpg 600w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/sci3734659-fig-0002-m-300x249.jpg 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/sci3734659-fig-0002-m-14x12.jpg 14w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><p id=\"caption-attachment-21179\" class=\"wp-caption-text\">\u56fe1\uff1a\u56fe\u793a\u4e3a\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09\u5728\u8111\u6897\u6b7b\u533a\u57df\u7684\u8840\u8111\u5c4f\u969c\uff08BBB\uff09\u4fdd\u62a4\u548c\u8fc1\u79fb\u80fd\u529b\u3002MSCs\u901a\u8fc7\u4e0b\u8c03\u6c34\u901a\u9053\u86cb\u767d4\uff08AQP4\uff09\u548c\u4e2d\u6027\u7c92\u7ec6\u80de\u91d1\u5c5e\u86cb\u767d\u91769\uff08NMP-9\uff09\u6765\u7ef4\u6301BBB\u7684\u5b8c\u6574\u6027\u3002\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u548c\u5c0f\u80f6\u8d28\u7ec6\u80de\u5206\u6cccSDF-1\uff0c\u4ece\u800c\u4fc3\u8fdbMSCs\u5411\u6897\u6b7b\u533a\u8d8b\u5316\u3002MSCs\u5206\u6ccc\u7684\u7ec6\u80de\u7ec4\u4fc3\u8fdb\u6297\u708e\u6027\u5c0f\u80f6\u8d28\u7ec6\u80de\uff08M2\uff09\u5206\u5316\uff0c\u5e76\u4e0b\u8c03\u5355\u6838\u7ec6\u80de\u548c\u5de8\u566c\u7ec6\u80de\u5206\u5316\u3002<\/p><\/div>\n<\/section>\n<p>\u8fd9\u4e9b\u56e0\u5b50\u534f\u540c\u4f5c\u7528\uff0c\u5728\u514d\u75ab\u8c03\u8282\u3001\u4fc3\u8fdb\u8840\u7ba1\u65b0\u751f\u548c\u589e\u5f3a\u5185\u6e90\u6027\u795e\u7ecf\u53ef\u5851\u6027\u4e09\u5927\u65b9\u5411\u4e0a\u4fee\u590d\u5352\u4e2d\u540e\u53d7\u635f\u7684\u8111\u5fae\u73af\u5883\u3002<\/p>\n<h3><span class=\"ez-toc-section\" id=\"03%E3%80%81%E4%B8%B4%E5%BA%8A%E7%A0%94%E7%A9%B6%E8%BF%9B%E5%B1%95\"><\/span>03\u3001\u4e34\u5e8a\u7814\u7a76\u8fdb\u5c55<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>MSCs\u7684\u4e34\u5e8a\u8f6c\u5316\u7814\u7a76\u6700\u4e3a\u6d3b\u8dc3\u3002\u5728ClinicalTrials.gov\u4e0a\u6ce8\u518c\u7684\u76f8\u5173\u4e34\u5e8a\u8bd5\u9a8c\u5df2\u8d85\u8fc730\u9879\uff0c\u591a\u6570\u5904\u4e8eI\/II\u671f\u3002\u65e9\u671f\u8bd5\u9a8c\uff08\u5982NCT00174323\uff09\u4e00\u81f4\u8bc1\u5b9e\uff0c\u901a\u8fc7\u9759\u8109\u6216\u5c40\u90e8\u6ce8\u5c04MSCs\u6cbb\u7597\u5352\u4e2d\u60a3\u8005\u5b89\u5168\u6027\u826f\u597d\uff0c\u8010\u53d7\u6027\u9ad8\u3002<\/p>\n<p>\u8fd1\u5e74\u6765\uff0c\u89c4\u6a21\u66f4\u5927\u7684II\u671f\u8bd5\u9a8c\uff08\u5982MASTERS\u3001TREASURE\uff09\u867d\u672a\u5b8c\u5168\u8fbe\u5230\u4e3b\u8981\u7597\u6548\u7ec8\u70b9\uff0c\u4f46\u4e3a\u4f18\u5316\u7ed9\u836f\u65f6\u673a\u3001\u5242\u91cf\u548c\u60a3\u8005\u9009\u62e9\u63d0\u4f9b\u4e86\u5173\u952e\u6570\u636e\u3002\u76ee\u524d\uff0cIII\u671f\u8bd5\u9a8c\uff08\u5982MASTERS-2, NCT03545607\uff09\u6b63\u5728\u8fdb\u884c\u4e2d\uff0c\u65e8\u5728\u8fdb\u4e00\u6b65\u9a8c\u8bc1\u5176\u7597\u6548\u3002<\/p>\n<h2><span class=\"ez-toc-section\" id=\"04%E3%80%81%E8%BD%AC%E5%8C%96%E5%BA%94%E7%94%A8%E7%9A%84%E5%85%B3%E9%94%AE%E9%99%90%E5%88%B6%EF%BC%9A%E5%BC%82%E8%B4%A8%E6%80%A7%E3%80%81%E6%9C%BA%E5%88%B6%E5%A4%8D%E6%9D%82%E6%80%A7%E4%B8%8E%E6%A0%87%E5%87%86%E5%8C%96%E6%8C%91%E6%88%98\"><\/span>04\u3001\u8f6c\u5316\u5e94\u7528\u7684\u5173\u952e\u9650\u5236\uff1a\u5f02\u8d28\u6027\u3001\u673a\u5236\u590d\u6742\u6027\u4e0e\u6807\u51c6\u5316\u6311\u6218<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>\u5c3d\u7ba1\u524d\u666f\u5e7f\u9614\uff0c\u4f46MSCs\u7684\u5e7f\u6cdb\u5e94\u7528\u4ecd\u9762\u4e34\u82e5\u5e72\u6839\u672c\u6027\u6311\u6218\u3002\u9996\u8981\u9650\u5236\u662f\u7ec6\u80de\u7684\u5f02\u8d28\u6027\uff0c\u4e0d\u540c\u7ec4\u7ec7\u6765\u6e90\u3001\u4f9b\u4f53\u4e2a\u4f53\u5dee\u5f02\u53ca\u5236\u5907\u5de5\u827a\u4f1a\u5bfc\u81f4\u7ec6\u80de\u4ea7\u54c1\u5728\u6548\u80fd\u548c\u7279\u6027\u4e0a\u4e0d\u4e00\u81f4\uff0c\u4e3a\u6cbb\u7597\u6807\u51c6\u5316\u5e26\u6765\u5de8\u5927\u56f0\u96be\u3002<\/p>\n<p>\u5176\u6b21\uff0c\u5176\u4f5c\u7528\u673a\u5236\u9ad8\u5ea6\u590d\u6742\u4e14\u4f9d\u8d56\u4e8e\u5fae\u73af\u5883\uff0c\u5982\u4f55\u7cbe\u786e\u8c03\u63a7\u5176\u65c1\u5206\u6ccc\u6548\u5e94\u4ee5\u8fbe\u5230\u6700\u4f73\u7597\u6548\u4ecd\u9700\u6df1\u5165\u9610\u660e\u3002<\/p>\n<p>\u6b64\u5916\uff0c\u786e\u5b9a\u6700\u4f18\u7684\u6cbb\u7597\u65f6\u95f4\u7a97\u3001\u7ed9\u836f\u9014\u5f84\u3001\u7ec6\u80de\u5242\u91cf\uff0c\u4ee5\u53ca\u901a\u8fc7\u5927\u89c4\u6a21III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u83b7\u5f97\u786e\u5207\u7684\u7597\u6548\u8bc1\u636e\uff0c\u90fd\u662f\u5176\u8fc8\u5411\u5e38\u89c4\u4e34\u5e8a\u5b9e\u8df5\u524d\u5fc5\u987b\u89e3\u51b3\u7684\u5173\u952e\u95ee\u9898\u3002<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%E4%BA%8C%E3%80%81_%E7%A5%9E%E7%BB%8F%E5%B9%B2%E7%BB%86%E8%83%9E%EF%BC%88NSCs%EF%BC%89%EF%BC%9A%E7%9B%B4%E6%8E%A5%E7%9A%84%E2%80%9C%E7%BB%86%E8%83%9E%E6%9B%BF%E4%BB%A3%E8%80%85%E2%80%9D\"><\/span><strong>\u4e8c\u3001 \u795e\u7ecf\u5e72\u7ec6\u80de\uff08NSCs\uff09\uff1a\u76f4\u63a5\u7684\u201c\u7ec6\u80de\u66ff\u4ee3\u8005\u201d<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<h3><span class=\"ez-toc-section\" id=\"01%E3%80%81%E8%B5%B7%E6%BA%90%E4%B8%8E%E7%89%B9%E6%80%A7%EF%BC%9A%E5%8F%91%E8%82%B2%E4%B8%8E%E6%88%90%E5%B9%B4%E7%9A%84%E5%8A%A8%E6%80%81%E5%AD%98%E5%9C%A8\"><\/span>01\u3001\u8d77\u6e90\u4e0e\u7279\u6027\uff1a\u53d1\u80b2\u4e0e\u6210\u5e74\u7684\u52a8\u6001\u5b58\u5728<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><a href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/nsc\/20778.html\/\" target=\"_blank\" rel=\"noopener\">neural stem cell<\/a>\u662f\u5177\u6709\u81ea\u6211\u66f4\u65b0\u548c\u591a\u5411\u5206\u5316\u6f5c\u80fd\u7684\u6210\u4f53\u5e72\u7ec6\u80de\uff0c\u662f\u6784\u5efa\u548c\u4fee\u590d\u795e\u7ecf\u7cfb\u7edf\u7684\u57fa\u7840\u7ec6\u80de\u3002\u5728\u80da\u80ce\u53d1\u80b2\u9636\u6bb5\uff0c\u5b83\u4eec\u8d77\u6e90\u4e8e\u795e\u7ecf\u7ba1\uff0c\u901a\u8fc7\u5bf9\u79f0\u4e0e\u4e0d\u5bf9\u79f0\u5206\u88c2\u4ea7\u751f\u795e\u7ecf\u5143\u548c\u5404\u7c7b\u80f6\u8d28\u7ec6\u80de\uff0c\u662f\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u7684\u201c\u79cd\u5b50\u201d\u3002<\/p>\n<p>\u5728\u6210\u5e74\u5927\u8111\u4e2d\uff0cNSCs\u4e3b\u8981\u5b58\u5728\u4e8e\u8111\u5ba4\u4e0b\u533a\u548c\u6d77\u9a6c\u9f7f\u72b6\u56de\u7b49\u7279\u5b9a\u533a\u57df\uff0c\u901a\u5e38\u4fdd\u6301\u9759\u606f\u72b6\u6001\uff0c\u4f46\u5728\u8111\u7f3a\u8840\u3001\u635f\u4f24\u7b49\u75c5\u7406\u523a\u6fc0\u4e0b\u53ef\u88ab\u6fc0\u6d3b\uff0c\u4ea7\u751f\u65b0\u7684\u795e\u7ecf\u7ec6\u80de\u3002\u7136\u800c\uff0c\u5185\u6e90\u6027NSCs\u7684\u6fc0\u6d3b\u7a0b\u5ea6\u548c\u518d\u751f\u80fd\u529b\u6781\u5176\u6709\u9650\uff0c\u65e0\u6cd5\u6709\u6548\u5e94\u5bf9\u5982\u5352\u4e2d\u5bfc\u81f4\u7684\u5927\u89c4\u6a21\u795e\u7ecf\u7ec6\u80de\u6b7b\u4ea1\uff0c\u8fd9\u6784\u6210\u4e86\u5916\u6e90\u6027NSCs\u79fb\u690d\u6cbb\u7597\u7684\u7406\u8bba\u57fa\u7840\u3002<\/p>\n<h3><span class=\"ez-toc-section\" id=\"02%E3%80%81%E5%8D%92%E4%B8%AD%E6%81%A2%E5%A4%8D%E4%B8%AD%E7%9A%84%E4%BD%9C%E7%94%A8%E6%9C%BA%E5%88%B6%EF%BC%9A%E7%9B%B4%E6%8E%A5%E6%9B%BF%E4%BB%A3%E4%B8%8E%E8%90%A5%E5%85%BB%E6%94%AF%E6%8C%81%E5%8F%8C%E8%BD%A8%E5%B9%B6%E8%A1%8C\"><\/span>02\u3001\u5352\u4e2d\u6062\u590d\u4e2d\u7684\u4f5c\u7528\u673a\u5236\uff1a\u76f4\u63a5\u66ff\u4ee3\u4e0e\u8425\u517b\u652f\u6301\u53cc\u8f68\u5e76\u884c<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>NSCs\u6cbb\u7597\u5352\u4e2d\u7684\u4f5c\u7528\u673a\u5236\u5448\u73b0\u53cc\u91cd\u7279\u6027\uff0c<span dir=\"auto\" data-pm-slice=\"0 0 []\">Figure 2<\/span><span dir=\"auto\">\u603b\u7ed3\u4e86\u795e\u7ecf\u5e72\u7ec6\u80de\u7279\u6709\u7684\u6cbb\u7597\u673a\u5236\u3002<\/span><\/p>\n<section data-role=\"list\">\n<ul class=\"list-paddingleft-1\">\n<li>\u4e00\u65b9\u9762\uff0c\u5176\u6838\u5fc3\u4f18\u52bf\u5728\u4e8e\u56fa\u6709\u7684\u795e\u7ecf\u8c31\u7cfb\u5b9a\u5411\u5206\u5316\u6f5c\u80fd\uff0c\u80fd\u591f\u76f4\u63a5\u8fc1\u79fb\u81f3\u635f\u4f24\u533a\u57df\uff0c\u5e76\u5206\u5316\u4e3a\u795e\u7ecf\u5143\u3001\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u548c\u5c11\u7a81\u80f6\u8d28\u7ec6\u80de\uff0c\u76f4\u63a5\u66ff\u4ee3\u4e22\u5931\u7684\u7ec6\u80de\uff0c\u91cd\u5efa\u795e\u7ecf\u73af\u8def\u3002<\/li>\n<li>\u53e6\u4e00\u65b9\u9762\uff0c\u4e0e\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u7c7b\u4f3c\uff0cNSCs\u4e5f\u901a\u8fc7\u5f3a\u5927\u7684\u65c1\u5206\u6ccc\u4f5c\u7528\u53d1\u6325\u7597\u6548\uff0c\u91ca\u653e\u8111\u6e90\u6027\u795e\u7ecf\u8425\u517b\u56e0\u5b50\uff08BDNF\uff09\u3001\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\uff08VEGF\uff09\u3001\u8840\u5c0f\u677f\u53cd\u5e94\u86cb\u767d\uff08TSP1\/2\uff09\u7b49\u591a\u79cd\u56e0\u5b50\u3002<\/li>\n<\/ul>\n<\/section>\n<section>\n<div id=\"attachment_21178\" style=\"width: 610px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-21178\" class=\"wp-image-21178 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/sci3734659-fig-0003-m.jpg\" alt=\"\" width=\"600\" height=\"447\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/sci3734659-fig-0003-m.jpg 600w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/sci3734659-fig-0003-m-300x224.jpg 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/sci3734659-fig-0003-m-16x12.jpg 16w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><p id=\"caption-attachment-21178\" class=\"wp-caption-text\">\u56fe2\uff1a\u56fe\u793a\u79fb\u690d\u7684\u795e\u7ecf\u5e72\u7ec6\u80de\uff08NSCs\uff09\u7684\u795e\u7ecf\u8c03\u63a7\u529f\u80fd\u3002GAP-43\u7684\u8868\u8fbe\u8868\u660e\u7a81\u89e6\u751f\u6210\u6d3b\u8dc3\u3002NSCs\u79ef\u6781\u5206\u88c2\u5e76\u66ff\u6362\u51cb\u4ea1\u7684\u795e\u7ecf\u5143\uff0c\u540c\u65f6\u4fc3\u8fdb\u6811\u7a81\u53ef\u5851\u6027\u548c\u8f74\u7a81\u840c\u751f\u3002NSCs\u901a\u8fc7\u5206\u6cccGDNF\u3001TSP1\/2\u3001IGF-1\u548cVEGF\u4fc3\u8fdb\u795e\u7ecf\u53d1\u751f\uff08\u84dd\u8272\uff09\u548c\u8840\u7ba1\u751f\u6210\uff08\u7eff\u8272\uff09\u3002<\/p><\/div>\n<\/section>\n<p>\u8fd9\u4e9b\u56e0\u5b50\u534f\u540c\u4f5c\u7528\uff0c\u53ef\u6291\u5236\u708e\u75c7\u3001\u4fc3\u8fdb\u8840\u7ba1\u65b0\u751f\u3001\u4fdd\u62a4\u73b0\u5b58\u795e\u7ecf\u5143\u5e76\u589e\u5f3a\u5185\u6e90\u6027\u795e\u7ecf\u53ef\u5851\u6027\uff0c\u4e3a\u7ec6\u80de\u66ff\u4ee3\u548c\u65b0\u7ec6\u80de\u7684\u6574\u5408\u521b\u9020\u6709\u5229\u7684\u5fae\u73af\u5883\u3002<\/p>\n<h3><span class=\"ez-toc-section\" id=\"03%E3%80%81%E4%B8%B4%E5%BA%8A%E7%A0%94%E7%A9%B6%E8%BF%9B%E5%B1%95%EF%BC%9A%E6%97%A9%E6%9C%9F%E6%8E%A2%E7%B4%A2%E4%B8%8E%E6%9D%A5%E6%BA%90%E5%AE%89%E5%85%A8%E6%80%A7%E7%9A%84%E6%BC%94%E8%BF%9B\"><\/span>03\u3001\u4e34\u5e8a\u7814\u7a76\u8fdb\u5c55\uff1a\u65e9\u671f\u63a2\u7d22\u4e0e\u6765\u6e90\u5b89\u5168\u6027\u7684\u6f14\u8fdb<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>NSCs\u7684\u4e34\u5e8a\u63a2\u7d22\u8f83\u65e9\u4f46\u9053\u8def\u66f2\u6298\u3002\u65e9\u671f\u7814\u7a76\uff08\u5982\u4f7f\u7528NT2\/D1\u7ec6\u80de\u7cfb\uff09\u663e\u793a\u4e86\u5b89\u5168\u6027\u53ca\u521d\u6b65\u529f\u80fd\u6539\u5584\u8ff9\u8c61\u3002PISCES\u7cfb\u5217\u4e34\u5e8a\u8bd5\u9a8c\uff08\u4f7f\u7528\u4eba\u80ce\u513f\u76ae\u5c42\u6765\u6e90\u7684CTX0E03\u7ec6\u80de\uff09\u662f\u91cd\u8981\u91cc\u7a0b\u7891\uff0c\u8bc1\u5b9e\u4e86\u9885\u5185\u79fb\u690dNSCs\u7684\u957f\u671f\u5b89\u5168\u6027\uff0c\u5e76\u5728\u7279\u5b9a\u60a3\u8005\u4e9a\u7ec4\u4e2d\u89c2\u5bdf\u5230\u4e0a\u80a2\u8fd0\u52a8\u529f\u80fd\u6539\u5584\u3002\u76ee\u524d\uff0c\u7814\u7a76\u91cd\u70b9\u8f6c\u5411\u66f4\u5b89\u5168\u3001\u53ef\u518d\u751f\u7684iPSCs\u6765\u6e90\u7684NSCs\u3002<\/p>\n<h3><span class=\"ez-toc-section\" id=\"04%E3%80%81%E8%BD%AC%E5%8C%96%E5%BA%94%E7%94%A8%E7%9A%84%E5%85%B3%E9%94%AE%E9%99%90%E5%88%B6%EF%BC%9A%E6%9D%A5%E6%BA%90%E3%80%81%E5%AD%98%E6%B4%BB%E4%B8%8E%E6%95%B4%E5%90%88%E7%9A%84%E4%B8%A5%E5%B3%BB%E6%8C%91%E6%88%98\"><\/span>04\u3001\u8f6c\u5316\u5e94\u7528\u7684\u5173\u952e\u9650\u5236\uff1a\u6765\u6e90\u3001\u5b58\u6d3b\u4e0e\u6574\u5408\u7684\u4e25\u5cfb\u6311\u6218<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>NSCs\u7684\u4e34\u5e8a\u5e94\u7528\u9762\u4e34\u4e00\u7cfb\u5217\u4e25\u5cfb\u7684\u79d1\u5b66\u4e0e\u6280\u672f\u74f6\u9888\u3002\u9996\u5148\uff0c\u7ec6\u80de\u6765\u6e90\u4e0e\u5236\u5907\u662f\u6839\u672c\u6311\u6218\uff0c\u539f\u4ee3\u83b7\u53d6\u56f0\u96be\u4e14\u5177\u6709\u4f26\u7406\u4e89\u8bae\uff0c\u800c\u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de\u6765\u6e90\u5219\u9700\u89e3\u51b3\u81f4\u7624\u98ce\u9669\u4e0e\u5206\u5316\u7eaf\u5ea6\u95ee\u9898\u3002\u5176\u6b21\uff0c\u79fb\u690d\u540e\u7ec6\u80de\u7684\u5b58\u6d3b\u7387\u4f4e\u3001\u529f\u80fd\u6574\u5408\u6548\u7387\u5dee\u662f\u4e3b\u8981\u969c\u788d\uff0c\u7f3a\u8840\u533a\u57df\u7684\u6076\u52a3\u5fae\u73af\u5883\u4e25\u91cd\u963b\u788d\u4e86\u79fb\u690d\u7ec6\u80de\u7684\u5b9a\u690d\u4e0e\u7a81\u89e6\u8fde\u63a5\u3002<\/p>\n<p>\u6b64\u5916\uff0c\u514d\u75ab\u6392\u65a5\u98ce\u9669\uff08\u5c24\u5176\u5f02\u79cd\u79fb\u690d\uff09\u3001\u4f9b\u4f53\u7ec6\u80de\u7684\u9ad8\u5ea6\u53d8\u5f02\u6027\u4ee5\u53ca\u6700\u4f73\u79fb\u690d\u65f6\u673a\u3001\u9014\u5f84\u548c\u5242\u91cf\u7684\u4e0d\u786e\u5b9a\u6027\uff0c\u5171\u540c\u5236\u7ea6\u4e86\u5176\u6cbb\u7597\u6548\u679c\u7684\u53ef\u9760\u6027\u4e0e\u53ef\u91cd\u590d\u6027\u3002\u56e0\u6b64\uff0c\u5982\u4f55\u4fdd\u969c\u5b89\u5168\u3001\u7a33\u5b9a\u4e14\u529f\u80fd\u5b8c\u5584\u7684NSCs\u6765\u6e90\uff0c\u5e76\u63d0\u9ad8\u5176\u5728\u5bbf\u4e3b\u8111\u5185\u7684\u5b58\u6d3b\u4e0e\u6574\u5408\u6548\u7387\uff0c\u662f\u5f53\u524d\u8f6c\u5316\u7814\u7a76\u7684\u6838\u5fc3\u8bfe\u9898\u3002<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%E4%B8%89%E3%80%81_%E8%AF%B1%E5%AF%BC%E5%A4%9A%E8%83%BD%E5%B9%B2%E7%BB%86%E8%83%9E%EF%BC%88iPSCs%EF%BC%89%EF%BC%9A%E4%B8%AA%E6%80%A7%E5%8C%96%E7%9A%84%E2%80%9C%E5%85%A8%E8%83%BD%E7%A7%8D%E5%AD%90%E5%BA%93%E2%80%9D\"><\/span><strong>\u4e09\u3001 \u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de\uff08iPSCs\uff09\uff1a\u4e2a\u6027\u5316\u7684\u201c\u5168\u80fd\u79cd\u5b50\u5e93\u201d<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<h3><span class=\"ez-toc-section\" id=\"01%E3%80%81%E8%B5%B7%E6%BA%90%E4%B8%8E%E6%A0%B8%E5%BF%83%E4%BC%98%E5%8A%BF%EF%BC%9A%E4%BD%93%E7%BB%86%E8%83%9E%E9%87%8D%E7%BC%96%E7%A8%8B%E5%BC%80%E5%90%AF%E4%B8%AA%E6%80%A7%E5%8C%96%E6%B2%BB%E7%96%97%E6%97%B6%E4%BB%A3\"><\/span>01\u3001\u8d77\u6e90\u4e0e\u6838\u5fc3\u4f18\u52bf\uff1a\u4f53\u7ec6\u80de\u91cd\u7f16\u7a0b\u5f00\u542f\u4e2a\u6027\u5316\u6cbb\u7597\u65f6\u4ee3<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de\u5e76\u975e\u6e90\u81ea\u80da\u80ce\u6216\u7279\u5b9a\u6210\u4f53\u7ec4\u7ec7\uff0c\u800c\u662f\u901a\u8fc7\u751f\u7269\u6280\u672f\u5c06\u6210\u719f\u4f53\u7ec6\u80de\uff08\u5982\u76ae\u80a4\u6210\u7ea4\u7ef4\u7ec6\u80de\uff09\u201c\u9006\u8f6c\u201d\u56de\u80da\u80ce\u6837\u591a\u80fd\u72b6\u6001\u800c\u83b7\u5f97\uff08\u56fe3\uff09\u3002\u5176\u6838\u5fc3\u6280\u672f\u7a81\u7834\u6e90\u4e8e2006\u5e74\u5c71\u4e2d\u4f38\u5f25\u56e2\u961f\u53d1\u73b0\u7684\u201cOSKM\u201d\u8f6c\u5f55\u56e0\u5b50\u7ec4\u5408\uff0c\u901a\u8fc7\u75c5\u6bd2\u8f7d\u4f53\u5bfc\u5165\u53ef\u5b9e\u73b0\u91cd\u7f16\u7a0b\u3002<\/p>\n<section>\n<div id=\"attachment_21180\" style=\"width: 610px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-21180\" class=\"wp-image-21180 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/sci3734659-fig-0001-m.jpg\" alt=\"\" width=\"600\" height=\"420\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/sci3734659-fig-0001-m.jpg 600w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/sci3734659-fig-0001-m-300x210.jpg 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/sci3734659-fig-0001-m-18x12.jpg 18w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><p id=\"caption-attachment-21180\" class=\"wp-caption-text\">\u56fe3\uff1a\u56fe\u793a\u4e3a\u76ee\u524d\u5c06\u4f53\u7ec6\u80de\u91cd\u7f16\u7a0b\u4e3a\u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de\uff08iPSCs\uff09\u7684\u673a\u5236\u3002\u7ec6\u80de\u91cd\u7f16\u7a0b\u53ef\u901a\u8fc7OKSM\u548cThompson\u7c07\u8f6c\u5f55\u56e0\u5b50\u7684\u7ec4\u5408\uff0c\u6216\u901a\u8fc7CRISPR-Cas9\u57fa\u56e0\u7f16\u8f91\u5b9e\u73b0\u3002<\/p><\/div>\n<\/section>\n<p>\u6b64\u540e\uff0c\u6280\u672f\u4e0d\u65ad\u6f14\u8fdb\uff0c\u5f00\u53d1\u4e86\u975e\u6574\u5408\u578b\u4ed9\u53f0\u75c5\u6bd2\u3001\u5fae\u73afDNA\u7b49\u66f4\u5b89\u5168\u7684\u8f7d\u4f53\u4ee5\u964d\u4f4e\u81f4\u7624\u98ce\u9669\u3002iPSCs\u6700\u9769\u547d\u6027\u7684\u4f18\u52bf\u5728\u4e8e\u5176\u81ea\u4f53\u6765\u6e90\u7684\u53ef\u80fd\u6027\uff0c\u5373\u7528\u60a3\u8005\u81ea\u8eab\u7684\u7ec6\u80de\u5236\u9020\u6cbb\u7597\u7528\u7ec6\u80de\uff0c\u4ece\u800c\u5728\u7406\u8bba\u4e0a\u907f\u514d\u4e86\u514d\u75ab\u6392\u65a5\uff0c\u5e76\u4e3a\u518d\u751f\u533b\u5b66\u63d0\u4f9b\u4e86\u8fd1\u4e4e\u65e0\u9650\u7684\u3001\u7b26\u5408\u4f26\u7406\u7684\u4e2a\u6027\u5316\u7ec6\u80de\u6765\u6e90\u3002<\/p>\n<h3><span class=\"ez-toc-section\" id=\"02%E3%80%81%E5%8D%92%E4%B8%AD%E6%81%A2%E5%A4%8D%E4%B8%AD%E7%9A%84%E4%BD%9C%E7%94%A8%E6%9C%BA%E5%88%B6%EF%BC%9A%E5%85%A8%E8%83%BD%E5%88%86%E5%8C%96%E4%B8%8E%E5%A4%9A%E6%95%88%E4%BF%AE%E5%A4%8D%E7%9A%84%E7%BB%93%E5%90%88\"><\/span>02\u3001\u5352\u4e2d\u6062\u590d\u4e2d\u7684\u4f5c\u7528\u673a\u5236\uff1a\u5168\u80fd\u5206\u5316\u4e0e\u591a\u6548\u4fee\u590d\u7684\u7ed3\u5408<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>iPSCs\u672c\u8eab\u5e76\u975e\u76f4\u63a5\u7528\u4e8e\u79fb\u690d\uff0c\u800c\u662f\u4f5c\u4e3a\u201c<span class=\"\">\u79cd\u5b50\u7ec6\u80de\u5e93<\/span>\u201d\uff0c\u9884\u5148\u5206\u5316\u4e3a\u6240\u9700\u7684\u529f\u80fd\u7ec6\u80de\uff08\u5982\u795e\u7ecf\u5e72\u7ec6\u80de\u3001\u7279\u5b9a\u795e\u7ecf\u5143\u6216\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6837\u7ec6\u80de\uff09\u540e\u518d\u8fdb\u884c\u79fb\u690d\u3002<\/p>\n<p>\u56e0\u6b64\uff0c\u5176\u6cbb\u7597\u673a\u5236\u878d\u5408\u5e76\u6269\u5c55\u4e86NSCs\u548cMSCs\u7684\u4f18\u52bf\uff1a<\/p>\n<section data-role=\"list\">\n<ul class=\"list-paddingleft-1\">\n<li>\u4e00\u65b9\u9762\uff0c\u5b83\u80fd\u5206\u5316\u4e3a\u771f\u6b63\u7684\u795e\u7ecf\u5143\uff0c\u76f4\u63a5\u66ff\u6362\u5352\u4e2d\u533a\u6b7b\u4ea1\u7ec6\u80de\uff0c\u5e76\u80fd\u5728\u5bbf\u4e3b\u8111\u5185\u5f62\u6210\u529f\u80fd\u6027\u7a81\u89e6\u8fde\u63a5\uff1b<\/li>\n<li>\u53e6\u4e00\u65b9\u9762\uff0c\u5b83\u53ca\u5176\u5206\u5316\u4ea7\u7269\u80fd\u901a\u8fc7\u5f3a\u5927\u7684\u65c1\u5206\u6ccc\u4f5c\u7528\uff0c\u5206\u6cccVEGF\u3001BDNF\u7b49\u591a\u79cd\u8425\u517b\u56e0\u5b50\uff0c\u53d1\u6325\u4e0eMSCs\u7c7b\u4f3c\u7684\u514d\u75ab\u8c03\u8282\uff08\u5982\u6291\u5236\u4fc3\u708e\u56e0\u5b50\uff09\u3001\u4fc3\u8fdb\u8840\u7ba1\u65b0\u751f\u548c\u4fdd\u62a4\u73b0\u5b58\u795e\u7ecf\u5143\u7684\u4f5c\u7528\u3002<\/li>\n<\/ul>\n<\/section>\n<p>\u8fd9\u79cd\u201c\u7ec6\u80de\u66ff\u4ee3\u201d\u4e0e\u201c\u8425\u517b\u652f\u6301\u201d\u7684\u53cc\u91cd\u80fd\u529b\uff0c\u4f7f\u5176\u4fee\u590d\u6f5c\u529b\u7406\u8bba\u4e0a\u6700\u4e3a\u5168\u9762\u3002<\/p>\n<h3><span class=\"ez-toc-section\" id=\"03%E3%80%81%E4%B8%B4%E5%BA%8A%E7%A0%94%E7%A9%B6%E8%BF%9B%E5%B1%95%EF%BC%9A%E4%B8%B4%E5%BA%8A%E5%89%8D%E8%AF%81%E6%8D%AE%E5%85%85%E5%88%86%EF%BC%8C%E5%8D%92%E4%B8%AD%E4%B8%B4%E5%BA%8A%E5%BA%94%E7%94%A8%E6%96%B9%E5%85%B4%E6%9C%AA%E8%89%BE\"><\/span>03\u3001\u4e34\u5e8a\u7814\u7a76\u8fdb\u5c55\uff1a\u4e34\u5e8a\u524d\u8bc1\u636e\u5145\u5206\uff0c\u5352\u4e2d\u4e34\u5e8a\u5e94\u7528\u65b9\u5174\u672a\u827e<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u76ee\u524d\uff0ciPSCs\u5728\u7f3a\u8840\u6027\u5352\u4e2d\u6cbb\u7597\u9886\u57df\u5c1a\u5904\u4e8e\u4e34\u5e8a\u524d\u7814\u7a76\u5411\u65e9\u671f\u4e34\u5e8a\u8fc7\u6e21\u7684\u5173\u952e\u9636\u6bb5\u3002\u5176\u7597\u6548\u5df2\u5728\u5927\u91cf\u52a8\u7269\u6a21\u578b\u4e2d\u5f97\u5230\u9a8c\u8bc1\uff0c\u8bc1\u5b9e\u5176\u5728\u6539\u5584\u795e\u7ecf\u529f\u80fd\u3001\u4fc3\u8fdb\u7ec4\u7ec7\u4fee\u590d\u65b9\u9762\u7684\u6f5c\u529b\u3002<\/p>\n<p>\u5728\u66f4\u5e7f\u6cdb\u7684\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u9886\u57df\uff0c\u5982\u5e15\u91d1\u68ee\u75c5\uff0c\u57fa\u4e8eiPSCs\u5206\u5316\u7684\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u79fb\u690d\u5df2\u8fdb\u5165\u9996\u4f8b\u60a3\u8005\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u4e3a\u5176\u795e\u7ecf\u7cfb\u7edf\u5e94\u7528\u7684\u5b89\u5168\u6027\u548c\u53ef\u884c\u6027\u63d0\u4f9b\u4e86\u5148\u884c\u53c2\u8003\u3002\u5c3d\u7ba1\u9488\u5bf9\u5352\u4e2d\u7684\u76f4\u63a5\u4e34\u5e8a\u8bd5\u9a8c\u5c1a\u672a\u5927\u89c4\u6a21\u5c55\u5f00\uff0c\u4f46\u5176\u5f3a\u5927\u7684\u6f5c\u529b\u6b63\u63a8\u52a8\u7814\u7a76\u8005\u81f4\u529b\u4e8e\u5efa\u7acb\u6807\u51c6\u5316\u3001\u5b89\u5168\u7684\u5206\u5316\u65b9\u6848\uff0c\u4e3a\u5373\u5c06\u5230\u6765\u7684\u4e34\u5e8a\u63a2\u7d22\u5960\u5b9a\u57fa\u7840\u3002<\/p>\n<p>04\u3001\u8f6c\u5316\u5e94\u7528\u7684\u5173\u952e\u9650\u5236\uff1a\u5b89\u5168\u3001\u6210\u672c\u4e0e\u5236\u5907\u5de5\u827a\u7684\u4e25\u5cfb\u6311\u6218<\/p>\n<p>iPSCs\u8d70\u5411\u4e34\u5e8a\u9762\u4e34\u4e00\u7cfb\u5217\u6781\u9ad8\u95e8\u69db\u7684\u9650\u5236\u3002\u9996\u8981\u4e14\u6838\u5fc3\u7684\u9650\u5236\u662f\u5b89\u5168\u6027\u95ee\u9898\uff0c\u5c24\u5176\u662f\u81f4\u7624\u98ce\u9669\uff0c\u8fd9\u65e2\u53ef\u80fd\u6765\u6e90\u4e8e\u91cd\u7f16\u7a0b\u56e0\u5b50\uff08\u5982c-Myc\uff09\u7684\u6b8b\u7559\u6216\u518d\u6fc0\u6d3b\uff0c\u4e5f\u53ef\u80fd\u6765\u81ea\u672a\u5b8c\u5168\u5206\u5316\u7684iPSCs\u6c61\u67d3\u3002<\/p>\n<p>\u5176\u6b21\uff0c\u590d\u6742\u7684\u751f\u4ea7\u5de5\u827a\u5bfc\u81f4\u6210\u672c\u9ad8\u6602\u3001\u5468\u671f\u957f\u4e14\u96be\u4ee5\u6807\u51c6\u5316\uff0c\u4ece\u4f53\u7ec6\u80de\u91c7\u96c6\u3001\u91cd\u7f16\u7a0b\u3001\u5b9a\u5411\u5206\u5316\u5230\u4e25\u683c\u7684\u8d28\u63a7\uff08\u6392\u9664\u9057\u4f20\u5f02\u5e38\u548c\u81f4\u7624\u6027\uff09\uff0c\u6bcf\u4e00\u6b65\u90fd\u5145\u6ee1\u6280\u672f\u6311\u6218\uff0c\u4e25\u91cd\u963b\u788d\u5176\u6210\u4e3a\u53ef\u666e\u53ca\u7684\u7597\u6cd5\u3002<\/p>\n<p>\u6b64\u5916\uff0c\u5373\u4f7f\u4f7f\u7528\u81ea\u4f53iPSCs\uff0c\u5176\u8868\u89c2\u9057\u4f20\u8bb0\u5fc6\u548c\u5206\u5316\u8fc7\u7a0b\u4e2d\u7684\u514d\u75ab\u539f\u6027\u53d8\u5316\u4e5f\u53ef\u80fd\u5f15\u53d1\u610f\u60f3\u4e0d\u5230\u7684\u514d\u75ab\u53cd\u5e94\u3002\u56e0\u6b64\uff0c\u5982\u4f55\u5728\u786e\u4fdd\u7edd\u5bf9\u5b89\u5168\u7684\u524d\u63d0\u4e0b\uff0c\u5b9e\u73b0\u89c4\u6a21\u5316\u3001\u7ecf\u6d4e\u4e14\u7a33\u5b9a\u7684\u7ec6\u80de\u4ea7\u54c1\u751f\u4ea7\uff0c\u662f\u5176\u8f6c\u5316\u9053\u8def\u4e0a\u5fc5\u987b\u653b\u514b\u7684\u5821\u5792\u3002<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%E5%9B%9B%E3%80%81_%E5%B9%B2%E7%BB%86%E8%83%9E%E7%BB%99%E8%8D%AF%E9%80%94%E5%BE%84%EF%BC%9A%E7%96%97%E6%95%88%E7%9A%84%E5%85%B3%E9%94%AE%E5%86%B3%E5%AE%9A%E5%9B%A0%E7%B4%A0\"><\/span><strong>\u56db\u3001 \u5e72\u7ec6\u80de\u7ed9\u836f\u9014\u5f84\uff1a\u7597\u6548\u7684\u5173\u952e\u51b3\u5b9a\u56e0\u7d20<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p data-spm-anchor-id=\"5176.28103460.0.i10.96a07551yM2FXP\">\u5e72\u7ec6\u80de\u7684\u7ed9\u836f\u9014\u5f84\u548c\u65f6\u673a\u662f\u5352\u4e2d\u6cbb\u7597\u6548\u679c\u7684\u5173\u952e\u51b3\u5b9a\u56e0\u7d20\uff0c\u7ed9\u836f\u65b9\u5f0f\u53ef\u4ee5\u662f\u5168\u8eab\u7ed9\u836f\u6216\u5c40\u90e8\u7ed9\u836f\u3002\u56fe4\u6982\u8ff0\u4e86\u76ee\u524d\u7684\u7ed9\u836f\u9014\u5f84\u53ca\u5176\u5404\u81ea\u7684\u4f18\u52bf\u548c\u5c40\u9650\u6027\u3002<\/p>\n<section>\n<div id=\"attachment_21177\" style=\"width: 610px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-21177\" class=\"wp-image-21177 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/sci3734659-fig-0004-m.jpg\" alt=\"\" width=\"600\" height=\"405\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/sci3734659-fig-0004-m.jpg 600w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/sci3734659-fig-0004-m-300x203.jpg 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/sci3734659-fig-0004-m-18x12.jpg 18w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><p id=\"caption-attachment-21177\" class=\"wp-caption-text\">\u56fe4\uff1a\u5168\u8eab\uff08\u9759\u8109\u6ce8\u5c04\u3001\u52a8\u8109\u6ce8\u5c04\uff09\u548c\u5c40\u90e8\uff08\u8111\u5ba4\u5185\u6ce8\u5c04\u3001\u9f3b\u5185\u6ce8\u5c04\uff09\u5e72\u7ec6\u80de\u8f93\u9001\u65b9\u6cd5\u3002<\/p><\/div>\n<\/section>\n<p data-spm-anchor-id=\"5176.28103460.0.i10.96a07551yM2FXP\">\u65f6\u673a\u5c24\u4e3a\u91cd\u8981\uff1a\u5728\u5352\u4e2d\u540e24\u5c0f\u65f6\u5185\u4e14\u4e0d\u665a\u4e8e72\u5c0f\u65f6\u5185\u8fdb\u884c\u5e72\u7ec6\u80de\u79fb\u690d\uff0c\u53ef\u89c2\u5bdf\u5230\u6897\u6b7b\u4f53\u79ef\u6700\u5927\u7a0b\u5ea6\u7684\u51cf\u5c11\u548c\u529f\u80fd\u6539\u5584\u3002\u5728\u5352\u4e2d\u540e0-8\u5c0f\u65f6\u5185\u8fdb\u884c\u7684\u79fb\u690d\u53ef\u663e\u8457\u7f29\u5c0f\u6897\u6b7b\u9762\u79ef\uff0c\u800c24\u5c0f\u65f6\u540e\u8fdb\u884c\u7684\u79fb\u690d\u4ecd\u80fd\u6539\u5584\u884c\u4e3a\u8868\u73b0\u3002<\/p>\n<p data-spm-anchor-id=\"5176.28103460.0.i10.96a07551yM2FXP\">\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u5728\u4e9a\u6025\u6027\u671f\u548c\u6162\u6027\u671f\uff08\u5352\u4e2d\u540e7-30\u5929\uff09\u8fdb\u884c\u7684\u6cbb\u7597\u901a\u5e38\u6548\u679c\u8f83\u5dee\u3002\u8fd9\u4e9b\u53d1\u73b0\u5f3a\u8c03\u4e86\u5e72\u7ec6\u80de\u6cbb\u7597\u7684\u65f6\u95f4\u654f\u611f\u6027\uff0c\u4ee5\u53ca\u4f18\u5316\u6cbb\u7597\u7a97\u53e3\u4ee5\u8fbe\u5230\u6700\u4f73\u4e34\u5e8a\u7597\u6548\u7684\u5fc5\u8981\u6027\u3002<\/p>\n<ul class=\"list-paddingleft-1\">\n<li>\n<p data-spm-anchor-id=\"5176.28103460.0.i10.96a07551yM2FXP\"><a class=\"normal_text_link mp_article_text_link\" href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzkwOTEzMDY0Nw==&amp;mid=2247517222&amp;idx=1&amp;sn=72d7afffb1346e2daccadcdd13477cc8&amp;scene=21#wechat_redirect\" target=\"_blank\" rel=\"noopener nofollow\" data-itemshowtype=\"0\" data-linktype=\"2\">\u9798\u5185\u4e0e\u9759\u8109\u6ce8\u5c04\u5e72\u7ec6\u80de\u6cbb\u7597\u4e2d\u98ce\u540e\u9057\u75c7\uff1a\u5747\u80fd\u6539\u5584\u60a3\u8005\u795e\u7ecf\u529f\u80fd\u6062\u590d\u548c\u751f\u6d3b\u8d28\u91cf\uff0c\u4f46\u9759\u8109\u6ce8\u5c04\u5b89\u5168\u6027\u66f4\u4f18\uff01<\/a><\/p>\n<\/li>\n<\/ul>\n<h3><span class=\"ez-toc-section\" id=\"01%E3%80%81%E4%B8%BB%E8%A6%81%E7%BB%99%E8%8D%AF%E9%80%94%E5%BE%84%E7%9A%84%E5%88%86%E7%B1%BB%E4%B8%8E%E5%9F%BA%E6%9C%AC%E5%8E%9F%E7%90%86\"><\/span>01\u3001\u4e3b\u8981\u7ed9\u836f\u9014\u5f84\u7684\u5206\u7c7b\u4e0e\u57fa\u672c\u539f\u7406<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u5e72\u7ec6\u80de\u6cbb\u7597\u8111\u5352\u4e2d\u7684\u7ed9\u836f\u9014\u5f84\u4e3b\u8981\u5206\u4e3a\u5168\u8eab\u6027\u4e0e\u5c40\u90e8\u6027\u4e24\u5927\u7c7b\u3002\u5168\u8eab\u7ed9\u836f\u4ee5\u9759\u8109\u6ce8\u5c04\uff08IV\uff09 \u548c\u52a8\u8109\u6ce8\u5c04\uff08IA\uff09 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class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u4e0d\u540c\u7ed9\u836f\u9014\u5f84\u5728\u7597\u6548\u4e0e\u5b89\u5168\u6027\u95f4\u5b58\u5728\u663e\u8457\u6743\u8861\u3002\u7597\u6548\u65b9\u9762\uff0c\u52a8\u8109\u6ce8\u5c04\u56e0\u5176\u76f8\u5bf9\u7cbe\u51c6\u7684\u9776\u5411\u6027\uff0c\u5728\u52a8\u7269\u6a21\u578b\u4e2d\u663e\u793a\u51fa\u4f18\u4e8e\u9759\u8109\u6ce8\u5c04\u7684\u795e\u7ecf\u529f\u80fd\u6062\u590d\uff1b\u800c\u5c40\u90e8\u7ed9\u836f\u7684\u8111\u5ba4\u5185\u6ce8\u5c04\u5219\u80fd\u8ba9\u6700\u591a\u7ec6\u80de\u6ede\u7559\u4e8e\u75c5\u7076\uff0c\u7406\u8bba\u4e0a\u5c40\u90e8\u6cbb\u7597\u6548\u5e94\u6700\u5f3a\u3002<\/p>\n<p>\u5b89\u5168\u6027\u65b9\u9762\uff0c\u6570\u636e\u663e\u793a\u9759\u8109\u6ce8\u5c04\u7684\u4e0d\u826f\u4e8b\u4ef6\u603b\u53d1\u751f\u7387\u6700\u9ad8\uff08\u8fbe65.42%\uff09\uff0c\u4f46\u591a\u4e3a\u8f7b\u5ea6\u6216\u7cfb\u7edf\u6027\u53cd\u5e94\uff1b\u800c\u4fb5\u5165\u6027\u6700\u5f3a\u7684\u8111\u5ba4\u5185\u6ce8\u5c04\uff0c\u5176\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\uff08\u5982\u51fa\u8840\u3001\u611f\u67d3\uff09\u7684\u6bd4\u4f8b\u6700\u9ad8\uff0844.44%\uff09\u3002\u975e\u4fb5\u5165\u6027\u7684\u9f3b\u5185\u7ed9\u836f\u867d\u524d\u666f\u5e7f\u9614\uff0c\u4f46\u7597\u6548\u4e0e\u673a\u5236\u5c1a\u9700\u66f4\u591a\u4e34\u5e8a\u9a8c\u8bc1\u3002\u56e0\u6b64\uff0c\u9014\u5f84\u9009\u62e9\u9700\u7efc\u5408\u8003\u91cf\u6025\u6027\u671f\u8fd8\u662f\u6062\u590d\u671f\u6cbb\u7597\u3001\u60a3\u8005\u6574\u4f53\u72b6\u51b5\u53ca\u624b\u672f\u8010\u53d7\u80fd\u529b\u3002<\/p>\n<h3><span class=\"ez-toc-section\" id=\"03%E3%80%81%E7%94%9F%E7%89%A9%E6%9D%90%E6%96%99%E8%BE%85%E5%8A%A9%E9%80%92%E9%80%81%E7%9A%84%E6%8A%80%E6%9C%AF%E8%BF%9B%E5%B1%95\"><\/span>03\u3001\u751f\u7269\u6750\u6599\u8f85\u52a9\u9012\u9001\u7684\u6280\u672f\u8fdb\u5c55<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u4e3a\u514b\u670d\u4f20\u7edf\u7ed9\u836f\u7684\u5c40\u9650\uff0c\u751f\u7269\u6750\u6599\u5de5\u7a0b\u6b63\u6210\u4e3a\u4f18\u5316\u9012\u9001\u7b56\u7565\u7684\u5173\u952e\u65b9\u5411\u3002\u5176\u6838\u5fc3\u76ee\u6807\u662f\u63d0\u9ad8\u79fb\u690d\u7ec6\u80de\u7684\u5b58\u6d3b\u7387\u3001\u9776\u5411\u6027\u4e0e\u529f\u80fd\u6301\u7eed\u6027\u3002<\/p>\n<p>\u4f8b\u5982\uff0c\u53ef\u6ce8\u5c04\u7684\u6c34\u51dd\u80f6\u80fd\u4e3a\u7ec6\u80de\u63d0\u4f9b\u4e09\u7ef4\u4fdd\u62a4\u6027\u5fae\u73af\u5883\uff0c\u5e76\u6301\u7eed\u91ca\u653e\u8425\u517b\u56e0\u5b50\uff1b\u7eb3\u7c73\u9897\u7c92\u53ef\u4f5c\u4e3a\u8f7d\u4f53\uff0c\u589e\u5f3a\u7ec6\u80de\u7684\u9776\u5411\u8fc1\u79fb\u6216\u5b9e\u73b0\u6cbb\u7597\u56e0\u5b50\u7684\u53ef\u63a7\u91ca\u653e\uff1b\u7ea4\u7ef4\u86cb\u767d\u80f6\u7b49\u652f\u67b6\u6750\u6599\u53ef\u76f4\u63a5\u586b\u5145\u6897\u6b7b\u8154\uff0c\u5c06\u7ec6\u80de\u56fa\u5b9a\u4e8e\u635f\u4f24\u533a\u57df\uff0c\u4fc3\u8fdb\u5176\u5b9a\u690d\u4e0e\u5206\u5316\u3002<\/p>\n<p>\u672a\u6765\uff0c\u590d\u5408\u7cfb\u7edf\uff08\u5982\u8f7d\u7eb3\u7c73\u9897\u7c92\u7684\u6c34\u51dd\u80f6\uff09\u6709\u671b\u901a\u8fc7\u534f\u540c\u4f5c\u7528\uff0c\u66f4\u667a\u80fd\u5730\u5bf9\u6297\u5352\u4e2d\u540e\u6709\u5bb3\u5fae\u73af\u5883\uff0c\u5b9e\u73b0\u7cbe\u51c6\u4fee\u590d\u3002<\/p>\n<h3><span class=\"ez-toc-section\" id=\"04%E3%80%81%E4%B8%AA%E4%BD%93%E5%8C%96%E4%B8%8E%E7%B2%BE%E5%87%86%E5%8C%96%E7%9A%84%E9%80%92%E9%80%81%E7%AD%96%E7%95%A5\"><\/span>04\u3001\u4e2a\u4f53\u5316\u4e0e\u7cbe\u51c6\u5316\u7684\u9012\u9001\u7b56\u7565<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u7efc\u4e0a\u6240\u8ff0\uff0c\u4e0d\u5b58\u5728\u201c\u6700\u4f18\u201d\u7684\u901a\u7528\u7ed9\u836f\u9014\u5f84\uff0c\u5176\u9009\u62e9\u9ad8\u5ea6\u4f9d\u8d56\u4e8e\u6cbb\u7597\u76ee\u6807\u3001\u65f6\u95f4\u7a97\u548c\u7ec6\u80de\u7c7b\u578b\u3002\u6025\u6027\u671f\u6cbb\u7597\u53ef\u80fd\u66f4\u770b\u91cd\u5feb\u901f\u4e0e\u53ef\u53ca\u6027\uff0c\u800c\u6062\u590d\u671f\u4fee\u590d\u53ef\u80fd\u8ffd\u6c42\u75c5\u7076\u5185\u66f4\u9ad8\u7684\u7ec6\u80de\u9a7b\u7559\u3002<\/p>\n<p>\u672a\u6765\u7684\u53d1\u5c55\u8d8b\u52bf\u5c06\u662f\u5f00\u53d1\u4e2a\u4f53\u5316\u3001\u7cbe\u51c6\u5316\u7684\u9012\u9001\u65b9\u6848\uff0c\u5e76\u7ed3\u5408\u751f\u7269\u6750\u6599\u6280\u672f\u4ee5\u6700\u5927\u5316\u7597\u6548\u5e76\u63a7\u5236\u98ce\u9669\u3002\u901a\u8fc7\u5c06\u7279\u5b9a\u7ec6\u80de\u7c7b\u578b\u4e0e\u6700\u9002\u914d\u7684\u9012\u9001\u9014\u5f84\u53ca\u751f\u7269\u6750\u6599\u76f8\u7ed3\u5408\uff0c\u6709\u671b\u7cfb\u7edf\u6027\u63d0\u5347\u5e72\u7ec6\u80de\u6cbb\u7597\u8111\u5352\u4e2d\u7684\u53ef\u9760\u6027\u3001\u5b89\u5168\u6027\u4e0e\u6709\u6548\u6027\uff0c\u63a8\u52a8\u5176\u4ece\u5b9e\u9a8c\u7814\u7a76\u5411\u6210\u719f\u4e34\u5e8a\u6cbb\u7597\u7684\u8f6c\u5316\u3002<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%E4%BA%94%E3%80%81%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E4%B8%AD%E9%A3%8E%E7%9A%84%E4%B8%B4%E5%BA%8A%E8%AF%95%E9%AA%8C%E5%8E%86%E5%8F%B2\"><\/span><strong>\u4e94\u3001\u5e72\u7ec6\u80de\u6cbb\u7597\u4e2d\u98ce\u7684\u4e34\u5e8a\u8bd5\u9a8c\u5386\u53f2<\/strong><span 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id=\"attachment_21182\" style=\"width: 2560px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-21182\" class=\"wp-image-21182 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/\u5de5\u4f5c\u7c3f1_Sheet137.png\" alt=\"\" width=\"2550\" height=\"5344\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/\u5de5\u4f5c\u7c3f1_Sheet137.png 2550w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/\u5de5\u4f5c\u7c3f1_Sheet137-143x300.png 143w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/\u5de5\u4f5c\u7c3f1_Sheet137-489x1024.png 489w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/\u5de5\u4f5c\u7c3f1_Sheet137-768x1609.png 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/\u5de5\u4f5c\u7c3f1_Sheet137-733x1536.png 733w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/\u5de5\u4f5c\u7c3f1_Sheet137-977x2048.png 977w, 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class=\"wp-caption-text\">\u88681\uff1a\u4f7f\u7528\u5e72\u7ec6\u80de\u6cbb\u7597\u4e2d\u98ce\u7684\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/p><\/div>\n<\/section>\n<p>\u9020\u8840\u5e72\u7ec6\u80de\/\u9aa8\u9ad3\u5355\u6838\u7ec6\u80de\uff1a\u65e9\u671f\u8bd5\u9a8c\u8bc1\u5b9e\u4e86\u5b89\u5168\u6027\uff0c\u4f46\u5927\u89c4\u6a21III\u671f\u8bd5\u9a8c\uff08\u5982TREASURE\uff09\u672a\u663e\u793a\u663e\u8457\u4e34\u5e8a\u83b7\u76ca\uff0c\u63d0\u793a\u9700\u4f18\u5316\u60a3\u8005\u9009\u62e9\u4e0e\u7ed9\u836f\u7b56\u7565\u3002<\/p>\n<p>\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff1a\u79ef\u7d2f\u4e86\u6700\u591a\u7684\u5b89\u5168\u6027\u4e0e\u53ef\u884c\u6027\u6570\u636e\u3002\u5c3d\u7ba1\u90e8\u5206II\u671f\u8bd5\u9a8c\u7ed3\u679c\u672a\u8fbe\u7ec8\u70b9\uff0c\u4f46\u957f\u671f\u968f\u8bbf\u663e\u793a\u90e8\u5206\u60a3\u8005\u529f\u80fd\u6301\u7eed\u6539\u5584\u3002III\u671f\u8bd5\u9a8c\u6b63\u5728\u8fdb\u884c\u4e2d\u3002<\/p>\n<ul class=\"list-paddingleft-1\">\n<li><a class=\"normal_text_link mp_article_text_link\" href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzkwOTEzMDY0Nw==&amp;mid=2247514950&amp;idx=1&amp;sn=01191057bc41a6438063e67d72071af3&amp;scene=21#wechat_redirect\" target=\"_blank\" rel=\"noopener nofollow\" data-itemshowtype=\"0\" data-linktype=\"2\">\u6700\u65b0\u7efc\u8ff0\uff1a\u8c08\u8c08\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6cbb\u7597\u4e2d\u98ce\u7684\u673a\u5236\u3001\u6848\u4f8b\u53ca\u672a\u6765\u53d1\u5c55\u65b9\u5411<\/a><\/li>\n<\/ul>\n<p>\u795e\u7ecf\u8c31\u7cfb\u5e72\u7ec6\u80de\uff1aPISCES\u8bd5\u9a8c\u8bc1\u660e\u4e86\u9885\u5185\u79fb\u690d\u7684\u5b89\u5168\u6027\uff0c\u5e76\u5728\u9884\u8bbe\u4e9a\u7ec4\u4e2d\u89c2\u5bdf\u5230\u529f\u80fd\u6539\u5584\u3002\u672a\u6765\u65b9\u5411\u805a\u7126\u4e8eiPSCs\u6765\u6e90\u7684NSCs\u3002<\/p>\n<ul class=\"list-paddingleft-1\">\n<li><a class=\"normal_text_link mp_article_text_link\" href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzkwOTEzMDY0Nw==&amp;mid=2247514655&amp;idx=1&amp;sn=c2e87ad6cb22b184d8537f341cc7a8c5&amp;scene=21#wechat_redirect\" target=\"_blank\" rel=\"noopener nofollow\" data-itemshowtype=\"0\" data-linktype=\"2\">\u9996\u6b21\u4eba\u4f53\u8bd5\u9a8c\uff1a\u80da\u80ce\u795e\u7ecf\u5e72\u7ec6\u80de\u6cbb\u7597\u7f3a\u8840\u6027\u4e2d\u98ce\u7684\u4e34\u5e8a\u7814\u7a76\u8868\u660e\u8fd0\u52a8\u529f\u80fd\u6539\u5584\uff0c\u5b89\u5168\u4e14\u8010\u53d7\u6027\u826f\u597d<\/a><\/li>\n<\/ul>\n<h2><span class=\"ez-toc-section\" id=\"%E5%85%AD%E3%80%81%E7%BB%93%E8%AE%BA%E4%B8%8E%E6%9C%AA%E6%9D%A5%E5%B1%95%E6%9C%9B\"><\/span><strong>\u516d\u3001\u7ed3\u8bba\u4e0e\u672a\u6765\u5c55\u671b<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>\u5e72\u7ec6\u80de\u7597\u6cd5\u4e3a\u5352\u4e2d\u4fee\u590d\u5e26\u6765\u4e86\u8303\u5f0f\u8f6c\u53d8\uff0c\u5176\u6838\u5fc3\u673a\u5236\u5e76\u975e\u7b80\u5355\u7684\u7ec6\u80de\u66ff\u6362\uff0c\u800c\u662f\u901a\u8fc7\u65c1\u5206\u6ccc\u4ecb\u5bfc\u7684\u591a\u5143\u4fee\u590d\uff08\u795e\u7ecf\u4fdd\u62a4\u3001\u514d\u75ab\u8c03\u8282\u3001\u8840\u7ba1\u65b0\u751f\u3001\u4fc3\u8fdb\u5185\u6e90\u6027\u518d\u751f\uff09\u6765\u91cd\u5851\u635f\u4f24\u5fae\u73af\u5883\u3002<\/p>\n<p><span dir=\"auto\" data-pm-slice=\"0 0 []\">\u5c3d\u7ba1\u4e0d\u540c\u7c7b\u578b\u7684\u5e72\u7ec6\u80de\u90fd\u5c55\u73b0\u51fa\u6cbb\u7597\u6f5c\u529b\uff0c\u4f46\u5b83\u4eec\u7684\u5c40\u9650\u6027\u5bf9\u4e34\u5e8a\u8f6c\u5316\u81f3\u5173\u91cd\u8981\u3002\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09\u9762\u4e34\u4f9b\u4f53\u5dee\u5f02\u548c\u5f02\u8d28\u6027\uff0c\u5f71\u54cd\u5176\u53ef\u91cd\u590d\u6027\uff1b\u795e\u7ecf\u5e72\u7ec6\u80de\uff08NSCs\uff09\u7531\u4e8e\u4f9d\u8d56\u4e8e\u80ce\u513f\u6216\u80bf\u7624\u6765\u6e90\u7684\u7ec6\u80de\u7cfb\uff0c\u5f15\u53d1\u4e86\u4f26\u7406\u548c\u6765\u6e90\u65b9\u9762\u7684\u62c5\u5fe7\uff1b\u800c\u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de\uff08iPSCs\uff09\u5219\u5b58\u5728\u81f4\u7624\u6027\u548c\u9ad8\u6602\u7684\u751f\u4ea7\u6210\u672c\u98ce\u9669\u3002<\/span><\/p>\n<p><span dir=\"auto\" data-pm-slice=\"0 0 []\">Figure 5<\/span><span dir=\"auto\">\u6bd4\u8f83\u4e86MSCs\u3001NSCs\u548ciPSCs\u7684\u6838\u5fc3\u7279\u5f81\uff0c\u91cd\u70b9\u9610\u8ff0\u4e86\u5b83\u4eec\u5404\u81ea\u7684\u4f18\u52bf\u548c\u5c40\u9650\u6027\u5982\u4f55\u5f71\u54cd\u6cbb\u7597\u65b9\u6848\u7684\u9009\u62e9\u3002<\/span><\/p>\n<section>\n<div id=\"attachment_21176\" style=\"width: 610px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-21176\" class=\"wp-image-21176 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/sci3734659-fig-0005-m.jpg\" alt=\"\" width=\"600\" height=\"641\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/sci3734659-fig-0005-m.jpg 600w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/sci3734659-fig-0005-m-281x300.jpg 281w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2025\/12\/sci3734659-fig-0005-m-11x12.jpg 11w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><p id=\"caption-attachment-21176\" class=\"wp-caption-text\">\u56fe5\uff1a\u56fe\u8868\u603b\u7ed3\u4e86\u95f4\u5145\u8d28\u5e72\u7ec6\u80de (MSC)\u3001\u795e\u7ecf\u5e72\u7ec6\u80de (NSC) \u548c\u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de (iPSC) \u5728\u4e2d\u98ce\u6cbb\u7597\u4e2d\u5e94\u7528\u7684\u5173\u952e\u7279\u5f81\u3002\u6bd4\u8f83\u7684\u7c7b\u522b\u5305\u62ec\u7ec6\u80de\u6765\u6e90\u3001\u5206\u5316\u80fd\u529b\u3001\u6cbb\u7597\u4f18\u52bf\u3001\u6cbb\u7597\u52a3\u52bf\u548c\u5f53\u524d\u4e34\u5e8a\u5e94\u7528\u72b6\u51b5\u3002<\/p><\/div>\n<\/section>\n<p>\u5f53\u524d\u7684\u7814\u7a76\u524d\u6cbf\u6b63\u4ece\u201c\u662f\u5426\u6709\u6548\u201d\u8f6c\u5411\u201c\u5982\u4f55\u4f18\u5316\u201d\uff0c\u7b56\u7565\u5305\u62ec\uff1a<\/p>\n<section data-role=\"list\">\n<section data-role=\"list\">\n<ul class=\"list-paddingleft-2\">\n<li>\u5229\u7528\u57fa\u56e0\u7f16\u8f91\uff08\u5982CRISPR\uff09\u589e\u5f3a\u7ec6\u80de\u529f\u80fd\u6216\u5b89\u5168\u6027\u3002<\/li>\n<li>\u5f00\u53d1\u65e0\u7ec6\u80de\u7684\u201c\u5206\u6ccc\u7ec4\u201d\u7597\u6cd5\uff0c\u89c4\u907f\u7ec6\u80de\u79fb\u690d\u98ce\u9669\u3002<\/li>\n<li>\u7ed3\u5408\u751f\u7269\u6750\u6599\u4f18\u5316\u9012\u9001\u6548\u7387\u3002<\/li>\n<li>\u4e25\u683c\u9075\u5faaSTEPS\u7b49\u8f6c\u5316\u6846\u67b6\uff0c\u7cbe\u7ec6\u5316\u5b9a\u4e49\u60a3\u8005\u5206\u5c42\u3001\u6cbb\u7597\u65f6\u95f4\u7a97\u53ca\u5eb7\u590d\u8054\u5408\u65b9\u6848\u3002<\/li>\n<\/ul>\n<\/section>\n<\/section>\n<p>\u672a\u6765\u7a81\u7834\u5c06\u4f9d\u8d56\u4e8e\u8de8\u5b66\u79d1\u7684\u7cfb\u7edf\u6027\u6574\u5408\u2014\u2014\u5c06\u7ec6\u80de\u751f\u7269\u5b66\u3001\u6750\u6599\u79d1\u5b66\u3001\u5f71\u50cf\u5b66\u4e0e\u4e34\u5e8a\u795e\u7ecf\u75c5\u5b66\u7d27\u5bc6\u7ed3\u5408\uff0c\u63a8\u52a8\u5e72\u7ec6\u80de\u7597\u6cd5\u4ece\u4e00\u9879\u524d\u666f\u5e7f\u9614\u7684\u7814\u7a76\uff0c\u8f6c\u5316\u4e3a\u53ef\u91cd\u590d\u3001\u5b89\u5168\u4e14\u60e0\u53ca\u5e7f\u5927\u5352\u4e2d\u60a3\u8005\u7684\u5e38\u89c4\u6cbb\u7597\u624b\u6bb5\u3002<\/p>\n<blockquote><p>\u4e3b\u8981\u53c2\u8003\u8d44\u6599\uff1a<\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">[1] <\/span><\/span><span data-pm-slice=\"0 0 []\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">Waszczuk, Daniel<\/span><\/span><\/span><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> , Manikandan, Shrivats, Manikandan, Varsha, Stone, Erian, Buehre, Shannon, Shore, Steiv, Panchatcharam, Manikandan, Miriyala, Sumitra, \u4ece\u5b9e\u9a8c\u5ba4\u5230\u4e34\u5e8a\uff1a\u5e72\u7ec6\u80de\u7597\u6cd5\u5728\u5352\u4e2d\u5eb7\u590d\u4e2d\u7684\u53d1\u5c55\u73b0\u72b6\uff0c\u00a0 <\/span><\/span><i><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u300a\u5e72\u7ec6\u80de\u56fd\u9645\u300b<\/span><\/span><\/i><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff0c2025\uff0c3734659\uff0c15\u9875\uff0c2025\u3002https:\/\/doi.org\/10.1155\/sci\/3734659<\/span><\/span><\/p>\n<p data-pm-slice=\"0 0 []\">Disclaimer: This article is intended only to disseminate scientific knowledge and share industry perspectives, and does not constitute any clinical diagnostic advice! The information published by Hangi Stem Cells is not a substitute for the professional advice of a physician or pharmacist. If you have any questions about copyright or other issues, please feel free to contact me.<\/p>\n<\/blockquote>","protected":false},"excerpt":{"rendered":"<p>\u5728\u5168\u7403\u8303\u56f4\u5185\uff0c\u4e2d\u98ce\uff08\u8111\u5352\u4e2d\uff09\u662f\u5bfc\u81f4\u6b7b\u4ea1\u548c\u6b8b\u75be\u7684\u4e3b\u8981\u539f\u56e0\u4e4b\u4e00\uff0c\u60a3\u8005\u5e38\u9762\u4e34\u6f2b\u957f\u7684\u5eb7\u590d\u8fc7\u7a0b\u4e0e\u4e0d\u53ef\u9006\u7684\u795e\u7ecf\u529f\u80fd\u7f3a\u635f\u3002\u4f20 [&hellip;]<\/p>","protected":false},"author":1,"featured_media":21175,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[76],"tags":[150,179,223],"_links":{"self":[{"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/posts\/21174"}],"collection":[{"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/comments?post=21174"}],"version-history":[{"count":2,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/posts\/21174\/revisions"}],"predecessor-version":[{"id":21184,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/posts\/21174\/revisions\/21184"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/media\/21175"}],"wp:attachment":[{"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/media?parent=21174"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/categories?post=21174"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/tags?post=21174"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}