{"id":21323,"date":"2026-01-27T01:11:43","date_gmt":"2026-01-26T09:11:43","guid":{"rendered":"https:\/\/www.hjtdsm.cn\/stem-cells\/stem-cell-therapy\/21323.html"},"modified":"2026-01-27T01:11:43","modified_gmt":"2026-01-26T09:11:43","slug":"%e9%97%b4%e5%85%85%e8%b4%a8%e5%b9%b2%e7%bb%86%e8%83%9e%e6%b2%bb%e7%96%97%e9%98%bf%e5%b0%94%e8%8c%a8%e6%b5%b7%e9%bb%98%e7%97%85%e6%9c%89%e6%95%88%e5%90%97%ef%bc%9f%e4%ba%94%e5%a4%a7%e4%b8%b4%e5%ba%8a","status":"publish","type":"post","link":"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/21323.html","title":{"rendered":"\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6cbb\u7597\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u6709\u6548\u5417\uff1f\u4e94\u5927\u4e34\u5e8a\u6848\u4f8b\u63ed\u793a\u7597\u6548\u4e0e\u5b89\u5168\u6027"},"content":{"rendered":"<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p>\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\uff08Alzheimer\u2019s Disease, AD\uff09\u4f5c\u4e3a\u4e00\u79cd\u8fdb\u884c\u6027\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\uff0c\u6b63\u65e5\u76ca\u6210\u4e3a\u5168\u7403\u516c\u5171\u536b\u751f\u7684\u91cd\u5927\u6311\u6218\u3002\u968f\u7740\u4eba\u53e3\u8001\u9f84\u5316\u52a0\u5267\uff0c\u4f20\u7edf\u7684\u836f\u7269\u6cbb\u7597\u4ec5\u80fd\u6682\u65f6\u7f13\u89e3\u75c7\u72b6\uff0c\u65e0\u6cd5\u9006\u8f6c\u75be\u75c5\u8fdb\u7a0b\u3002<\/p>\n<\/blockquote>\n<p>\u5728\u8fd9\u4e00\u80cc\u666f\u4e0b\uff0c\u57fa\u4e8e<span class=\"xintheme_tag_link\">mesenchymal stem cell MSC (in cell biology)<\/span>\uff08Mesenchymal Stem Cells, MSCs\uff09\u7684\u7ec6\u80de\u7597\u6cd5\uff0c\u4ee5\u5176\u72ec\u7279\u7684\u6297\u708e\u3001\u795e\u7ecf\u4fdd\u62a4\u53ca\u518d\u751f\u6f5c\u80fd\uff0c\u4e3a\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u6cbb\u7597\u5f00\u8f9f\u4e86\u5168\u65b0\u8def\u5f84\u3002\u4ee5\u4e0b\u5c06\u5206\u522b\u9610\u8ff0\u4e94\u9879\u5177\u6709\u4ee3\u8868\u6027\u7684\u4e34\u5e8a\u7814\u7a76\u6848\u4f8b\uff0c\u63ed\u793a\u95f4\u5145\u8d28<span class=\"xintheme_tag_link\">\u5e72\u7ec6\u80de\u6cbb\u7597\u963f\u5c14\u8328\u6d77\u9ed8\u75c5<\/span>\u7684\u6f5c\u529b\u4e0e\u8fdb\u5c55\u3002<\/p>\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" loading=\"lazy\" width=\"612\" height=\"408\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2026\/01\/20260126171141-69772fcda4777.jpg\" alt=\"\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6cbb\u7597\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u6709\u6548\u5417\uff1f\u4e94\u5927\u4e34\u5e8a\u6848\u4f8b\u63ed\u793a\u7597\u6548\u4e0e\u5b89\u5168\u6027\" class=\"wp-image-58899\" title=\"\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6cbb\u7597\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u6709\u6548\u5417\uff1f\u4e94\u5927\u4e34\u5e8a\u6848\u4f8b\u63ed\u793a\u7597\u6548\u4e0e\u5b89\u5168\u6027\"><figcaption class=\"wp-element-caption\">\u95f4\u5145\u8d28<span class=\"xintheme_tag_link\">stem cell therapy<\/span>\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u6709\u6548\u5417\uff1f\u4e94\u5927\u4e34\u5e8a\u6848\u4f8b\u63ed\u793a\u7597\u6548\u4e0e\u5b89\u5168\u6027<\/figcaption><\/figure>\n<p><button type=\"button\" id=\"ftwp-trigger\" class=\"ftwp-shape-round ftwp-border-medium\" title=\"click To Maximize The Table Of Contents\"><span class=\"ftwp-trigger-icon ftwp-icon-number\"><\/span><\/button><\/p>\n<nav id=\"ftwp-contents\" class=\"ftwp-shape-square ftwp-border-medium\">\n<header id=\"ftwp-header\"><span id=\"ftwp-header-control\" class=\"ftwp-icon-number\"><\/span><button type=\"button\" id=\"ftwp-header-minimize\" class=\"ftwp-icon-expand\" 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ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-27\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/21323.html\/#%E8%AE%A8%E8%AE%BA%E4%B8%8E%E5%90%AF%E7%A4%BA%EF%BC%9A%E8%87%AA%E4%BD%93%E7%96%97%E6%B3%95%E7%9A%84%E7%8B%AC%E7%89%B9%E6%8C%91%E6%88%98%E4%B8%8E%E6%96%B9%E6%A1%88%E5%8F%8D%E6%80%9D\" >\u8ba8\u8bba\u4e0e\u542f\u793a\uff1a\u81ea\u4f53\u7597\u6cd5\u7684\u72ec\u7279\u6311\u6218\u4e0e\u65b9\u6848\u53cd\u601d<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-28\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/21323.html\/#%E6%80%BB%E7%BB%93\" >\u603b\u7ed3<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-29\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/21323.html\/#%E5%8F%91%E5%B1%95%E8%84%89%E7%BB%9C%E4%B8%8E%E6%A0%B8%E5%BF%83%E5%8F%91%E7%8E%B0\" 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class=\"ftwp-text\">\u7ed3\u8bba\u4e0e\u542f\u793a\uff1a\u4f4e\u5242\u91cf\u4f18\u52bf\u4e0e\u672a\u6765\u65b9\u5411<\/span><\/li>\n<li class=\"ftwp-item\"><span class=\"ftwp-text\">\u4e34\u5e8a\u7814\u7a76\u6848\u4f8b\u56db\uff1alarmestrocel\u6cbb\u7597\u8f7b\u5ea6\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u540c\u79cd\u5f02\u4f53\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u7597\u6cd5\uff1a\u4e00\u9879\u968f\u673a\u5bf9\u71672a\u671f\u8bd5\u9a8c\u201d\u3002<\/span><\/li>\n<li class=\"ftwp-item\"><span class=\"ftwp-text\">\u8fdb\u9636\u7684\u968f\u673a\u5bf9\u7167\u4e0e\u591a\u5242\u91cf\u65b9\u6848\u8bbe\u8ba1<\/span><\/li>\n<li class=\"ftwp-item\"><span class=\"ftwp-text\">\u4f18\u5f02\u7684\u5b89\u5168\u6027\uff1a\u65e0ARIA\u98ce\u9669\u662f\u7a81\u51fa\u4eae\u70b9<\/span><\/li>\n<li class=\"ftwp-item\"><span class=\"ftwp-text\">\u79ef\u6781\u7684\u7597\u6548\u4fe1\u53f7\uff1a\u8ba4\u77e5\u3001\u529f\u80fd\u4e0e\u8111\u7ed3\u6784\u7684\u6539\u5584<\/span><\/li>\n<li class=\"ftwp-item\"><span class=\"ftwp-text\">\u7ed3\u8bba\u4e0e\u5c55\u671b\uff1a\u786e\u7acb\u75be\u75c5\u4fee\u9970\u6f5c\u529b\u4e0e\u4f18\u5316\u7ed9\u836f\u7b56\u7565<\/span><\/li>\n<li class=\"ftwp-item\"><span class=\"ftwp-text\">\u4e34\u5e8a\u7814\u7a76\u6848\u4f8b\u4e94\uff1aAstroStem\u6cbb\u7597\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u7684\u7814\u7a76\u3002<\/span><\/li>\n<li class=\"ftwp-item\"><span class=\"ftwp-text\">\u957f\u5468\u671f\u3001\u9ad8\u5f3a\u5ea6\u7684\u81ea\u4f53\u7ec6\u80de\u6cbb\u7597\u8bbe\u8ba1<\/span><\/li>\n<li class=\"ftwp-item\"><span class=\"ftwp-text\">\u5b89\u5168\u6027\u603b\u4f53\u53ef\u63a5\u53d7\uff0c\u4f46\u5b58\u5728\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\u62a5\u544a<\/span><\/li>\n<li class=\"ftwp-item\"><span class=\"ftwp-text\">\u7597\u6548\u7ed3\u679c\u672a\u663e\u793a\u79ef\u6781\u4fe1\u53f7\uff0c\u8ba4\u77e5\u4e0b\u964d\u8d8b\u52bf\u66f4\u4e3a\u660e\u663e<\/span><\/li>\n<li class=\"ftwp-item\"><span class=\"ftwp-text\">\u8ba8\u8bba\u4e0e\u542f\u793a\uff1a\u81ea\u4f53\u7597\u6cd5\u7684\u72ec\u7279\u6311\u6218\u4e0e\u65b9\u6848\u53cd\u601d<\/span><\/li>\n<li class=\"ftwp-item\"><span class=\"ftwp-text\">\u603b\u7ed3<\/span><\/li>\n<li class=\"ftwp-item\"><span class=\"ftwp-text\">\u53d1\u5c55\u8109\u7edc\u4e0e\u6838\u5fc3\u53d1\u73b0<\/span><\/li>\n<\/ol>\n<\/li>\n<\/ol>\n<\/nav>\n<h2 id=\"ftoc-heading-1\" class=\"wp-block-heading ftwp-heading\"><span class=\"ez-toc-section\" id=\"%E9%97%B4%E5%85%85%E8%B4%A8%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E9%98%BF%E5%B0%94%E8%8C%A8%E6%B5%B7%E9%BB%98%E7%97%85%E7%96%97%E6%95%88%E5%8F%8A%E5%AE%89%E5%85%A8%E6%80%A7%E6%80%8E%E4%B9%88%E6%A0%B7%EF%BC%9F%E4%BA%94%E9%A1%B9%E4%B8%B4%E5%BA%8A%E6%A1%88%E4%BE%8B%E5%88%86%E6%9E%90%E4%B8%8E%E6%9C%AA%E6%9D%A5%E5%B1%95%E6%9C%9B\"><\/span>\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6cbb\u7597\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7597\u6548\u53ca\u5b89\u5168\u6027\u600e\u4e48\u6837\uff1f\u4e94\u9879\u4e34\u5e8a\u6848\u4f8b\u5206\u6790\u4e0e\u672a\u6765\u5c55\u671b<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<h3 id=\"ftoc-heading-2\" class=\"wp-block-heading ftwp-heading\"><span class=\"ez-toc-section\" id=\"%E4%B8%B4%E5%BA%8A%E7%A0%94%E7%A9%B6%E6%A1%88%E4%BE%8B%E4%B8%80%EF%BC%9A%E4%BA%BA%E8%84%90%E5%B8%A6%E8%A1%80%E6%9D%A5%E6%BA%90%E7%9A%84MSC%E7%AB%8B%E4%BD%93%E5%AE%9A%E5%90%91%E8%84%91%E6%B3%A8%E5%B0%84%E5%88%B0%E9%98%BF%E5%B0%94%E8%8C%A8%E6%B5%B7%E9%BB%98%E7%97%85%E6%82%A3%E8%80%85%E4%BD%93%E5%86%85%EF%BC%9A%E4%B8%80%E9%A1%B91%E6%9C%9F%E4%B8%B4%E5%BA%8A%E8%AF%95%E9%AA%8C\"><\/span>\u4e34\u5e8a\u7814\u7a76\u6848\u4f8b\u4e00\uff1a\u4eba\u8110\u5e26\u8840\u6765\u6e90\u7684MSC\u7acb\u4f53\u5b9a\u5411\u8111\u6ce8\u5c04\u5230\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u60a3\u8005\u4f53\u5185\uff1a\u4e00\u98791\u671f\u4e34\u5e8a\u8bd5\u9a8c<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>2015\u5e74\uff0cKim\u7b49\u4eba\u8fdb\u884c\u4e86\u4e00\u9879 \u201c\u9488\u5bf9\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u60a3\u8005\u8fdb\u884c\u4eba\u8110\u5e26\u8840\u6765\u6e90\u7684\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u7acb\u4f53\u5b9a\u5411\u8111\u6ce8\u5c04\u76841\u671f\u4e34\u5e8a\u8bd5\u9a8c\u201d\uff08\u4e34\u5e8a\u8bd5\u9a8c\u6ce8\u518c\u53f7\uff1aNCT01297218\u548cNCT01696591\uff09<sup>[1]<\/sup>The<\/p>\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" loading=\"lazy\" width=\"708\" height=\"394\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2026\/01\/20260126171141-69772fcdc3c06.png\" alt=\"\u4eba\u8110\u5e26\u8840\u6765\u6e90\u7684MSC\u7acb\u4f53\u5b9a\u5411\u8111\u6ce8\u5c04\u5230\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u60a3\u8005\u4f53\u5185\uff1a\u4e00\u98791\u671f\u4e34\u5e8a\u8bd5\u9a8c\" class=\"wp-image-58898\" title=\"\u4eba\u8110\u5e26\u8840\u6765\u6e90\u7684MSC\u7acb\u4f53\u5b9a\u5411\u8111\u6ce8\u5c04\u5230\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u60a3\u8005\u4f53\u5185\uff1a\u4e00\u98791\u671f\u4e34\u5e8a\u8bd5\u9a8c\"><figcaption class=\"wp-element-caption\">\u4eba\u8110\u5e26\u8840\u6765\u6e90\u7684MSC\u7acb\u4f53\u5b9a\u5411\u8111\u6ce8\u5c04\u5230\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u60a3\u8005\u4f53\u5185\uff1a\u4e00\u98791\u671f\u4e34\u5e8a\u8bd5\u9a8c<\/figcaption><\/figure>\n<h3 id=\"ftoc-heading-3\" class=\"wp-block-heading ftwp-heading\"><span class=\"ez-toc-section\" id=\"%E7%B2%BE%E5%87%86%E7%9A%84%E7%AB%8B%E4%BD%93%E5%AE%9A%E5%90%91%E7%BB%99%E8%8D%AF%E6%96%B9%E6%A1%88\"><\/span>\u7cbe\u51c6\u7684\u7acb\u4f53\u5b9a\u5411\u7ed9\u836f\u65b9\u6848<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u8be5\u7814\u7a76\u662f\u4e00\u9879\u5f00\u653e\u6807\u7b7e\u3001\u5355\u4e2d\u5fc3\u7684\u2160\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5176\u6838\u5fc3\u662f\u901a\u8fc7\u9ad8\u5ea6\u7cbe\u786e\u7684\u7acb\u4f53\u5b9a\u5411\u624b\u672f\uff0c\u5c06\u4eba\u8110\u5e26\u8840\u6765\u6e90\u7684\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08hUCB-MSCs\uff09\u76f4\u63a5\u9012\u9001\u81f3\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\uff08AD\uff09\u7684\u65e9\u671f\u75c5\u53d8\u8111\u533a\u3002<\/p>\n<p>\u7814\u7a76\u91c7\u7528\u5242\u91cf\u9012\u589e\u8bbe\u8ba1\uff0c\u5c069\u540d\u5e74\u9f84\u572850-85\u5c81\u3001\u7b26\u5408NINCDS-ADRDA\u8bca\u65ad\u6807\u51c6\u4e14\u7ecfPiB-PET\u786e\u8ba4\u5b58\u5728\u6dc0\u7c89\u6837\u86cb\u767d\u75c5\u7406\u7684\u8f7b\u4e2d\u5ea6AD\u60a3\u8005\uff08MMSE\u8bc4\u520618-26\u5206\uff09\u5206\u4e3a\u4e24\u7ec4\uff1a<strong>\u4f4e\u5242\u91cf\u7ec4\uff083 \u00d7 10\u2076\u4e2a\u7ec6\u80de\uff09\u548c\u9ad8\u5242\u91cf\u7ec4\uff086 \u00d7 10\u2076\u4e2a\u7ec6\u80de\uff09<\/strong>\u3002\u5229\u7528MRI\u5f15\u5bfc\uff0c\u7ec6\u80de\u88ab\u6ce8\u5c04\u5230\u53cc\u4fa7\u6d77\u9a6c\u4f53\u548c\u53f3\u4fa7\u6954\u524d\u53f6\uff0c\u6bcf\u4e2a\u9776\u533a\u901a\u8fc74\u6761\u6ce8\u5c04\u8f68\u8ff9\u3001\u57284\u4e2a\u4e0d\u540c\u6df1\u5ea6\uff08\u95f4\u96945\u6beb\u7c73\uff09\u8fdb\u884c\u6c89\u79ef\uff0c\u4ee5\u786e\u4fdd\u7ec6\u80de\u5206\u5e03\u3002<\/p>\n<p>\u4e3b\u8981\u7ec8\u70b9\u662f\u8bc4\u4f30\u64cd\u4f5c\u5b89\u5168\u6027\u4e0e\u5242\u91cf\u9650\u5236\u6027\u6bd2\u6027\uff08DLT\uff09\uff0c\u6b21\u8981\u7ec8\u70b9\u5219\u63a2\u7d22\u6027\u5730\u8bc4\u4f30\u8ba4\u77e5\u529f\u80fd\uff08ADAS-Cog, MMSE\uff09\u3001\u65e5\u5e38\u751f\u6d3b\u80fd\u529b\uff08S-IADL\uff09\u3001\u795e\u7ecf\u5f71\u50cf\u5b66\uff08PiB-PET, FDG-PET\uff09\u53ca\u8111\u810a\u6db2\u751f\u7269\u6807\u5fd7\u7269\uff08A\u03b2, Tau, p-Tau\uff09\u7684\u53d8\u5316\uff0c\u968f\u8bbf\u671f\u957f\u8fbe24\u4e2a\u6708\u3002<\/p>\n<h3 id=\"ftoc-heading-4\" class=\"wp-block-heading ftwp-heading\"><span class=\"ez-toc-section\" id=\"%E6%98%8E%E7%A1%AE%E7%9A%84%E5%AE%89%E5%85%A8%E6%80%A7%E4%B8%8E%E8%89%AF%E5%A5%BD%E8%80%90%E5%8F%97%E6%80%A7\"><\/span>\u660e\u786e\u7684\u5b89\u5168\u6027\u4e0e\u826f\u597d\u8010\u53d7\u6027<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u7814\u7a76\u8be6\u7ec6\u7684\u5b89\u5168\u6027\u8bc4\u4f30\u8bc1\u5b9e\uff0c\u7acb\u4f53\u5b9a\u5411\u8111\u5185\u6ce8\u5c04hUCB-MSCs\u5177\u6709\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u3002\u6240\u67099\u540d\u60a3\u8005\u5747\u987a\u5229\u5b8c\u6210\u624b\u672f\uff0c\u672f\u540e\u5f71\u50cf\u5b66\uff08MRI\/CT\uff09\u672a\u53d1\u73b0\u9885\u5185\u51fa\u8840\u3001\u6025\u6027\u75c5\u7076\u6216\u7ed3\u6784\u6027\u635f\u4f24\u3002<\/p>\n<p>\u76d1\u6d4b\u671f\u95f4<strong>\u672a\u51fa\u73b0\u53d1\u70ed\u3001\u5168\u8eab\u611f\u67d3\u6216\u514d\u75ab\u6392\u65a5\u8ff9\u8c61<\/strong>\u3002\u8bb0\u5f55\u5230\u7684\u4e0d\u826f\u4e8b\u4ef6\u5747\u4e3a\u77ed\u6682\u4e14\u53ef\u81ea\u6108\u7684\u672f\u540e\u53cd\u5e94\uff0c\u5177\u4f53\u53d1\u751f\u7387\u4e3a\uff1a<strong>\u4f24\u53e3\u75bc\u75db\uff08100%\uff09\u3001\u5934\u75db\uff0844.4%\uff09\u3001\u5934\u6655\uff0833.3%\uff09\u3001\u8f7b\u5ea6\u8c35\u5984\uff0833.3%\uff09\u3001\u6076\u5fc3\u6216\u80cc\u75db\uff08\u540422.2%\uff09<\/strong>\u3002\u81f3\u5173\u91cd\u8981\u7684\u662f\uff0c<strong>\u672a\u89c2\u5bdf\u5230\u4efb\u4f55\u5242\u91cf\u9650\u5236\u6027\u6bd2\u6027\uff08DLT\uff09<\/strong>\uff0c\u4e14\u6ca1\u6709\u4e0d\u826f\u4e8b\u4ef6\u88ab\u76f4\u63a5\u5f52\u56e0\u4e8e\u7ec6\u80de\u5236\u54c1\u672c\u8eab\u3002<\/p>\n<p>\u957f\u8fbe24\u4e2a\u6708\u7684\u957f\u671f\u968f\u8bbf\u4e5f\u672a\u53d1\u73b0\u5ef6\u8fdf\u6027\u5e76\u53d1\u75c7\u3001\u80bf\u7624\u5f62\u6210\u6216\u795e\u7ecf\u708e\u75c7\u8ff9\u8c61\uff0c\u4ece\u64cd\u4f5c\u5c42\u9762\u786e\u7acb\u4e86\u8be5\u65b9\u6cd5\u7684\u5b89\u5168\u6027\u3002<\/p>\n<h3 id=\"ftoc-heading-5\" class=\"wp-block-heading ftwp-heading\"><span class=\"ez-toc-section\" id=\"%E7%96%97%E6%95%88%E8%AF%81%E6%8D%AE%E6%9C%AA%E8%BE%BE%E6%98%BE%E8%91%97%EF%BC%8C%E4%BD%86%E6%8F%90%E7%A4%BA%E5%89%82%E9%87%8F%E7%9B%B8%E5%85%B3%E8%B6%8B%E5%8A%BF\"><\/span>\u7597\u6548\u8bc1\u636e\u672a\u8fbe\u663e\u8457\uff0c\u4f46\u63d0\u793a\u5242\u91cf\u76f8\u5173\u8d8b\u52bf<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u5c3d\u7ba1\u8be5\u7814\u7a76\u7edf\u8ba1\u529f\u6548\u4e0d\u8db3\u4ee5\u5f97\u51fa\u786e\u5207\u7684\u7597\u6548\u7ed3\u8bba\uff0c\u4f46\u63a2\u7d22\u6027\u8bc4\u4f30\u63d0\u4f9b\u4e86\u8be6\u5c3d\u7684\u91cf\u5316\u6570\u636e\uff0c\u4e14\u672a\u663e\u793a\u51fa\u7edf\u8ba1\u5b66\u4e0a\u7684\u663e\u8457\u6539\u5584\u3002\u5728\u8ba4\u77e5\u529f\u80fd\u65b9\u9762\uff0c\u6cbb\u759712\u5468\u65f6\uff0c\u4f4e\u5242\u91cf\u7ec4ADAS-Cog\u8bc4\u5206\u6076\u5316<strong>+5.3 \u00b1 3.5<\/strong>\uff0c\u9ad8\u5242\u91cf\u7ec4\u6076\u5316<strong>+3.5\u00b15.6<\/strong>\uff1bMMSE\u8bc4\u5206\u5728\u4f4e\u5242\u91cf\u7ec4\u4e0b\u964d<strong>-1.7\u00b10.6<\/strong>\uff0c\u9ad8\u5242\u91cf\u7ec4\u8f7b\u5fae\u6539\u5584<strong>+0.5 \u00b1 2.1<\/strong>\u3002\u81f324\u4e2a\u6708\u65f6\uff0c\u8ba4\u77e5\u8870\u9000\u6301\u7eed\uff1a\u4f4e\u5242\u91cf\u7ec4ADAS-Cog\u589e\u52a0<strong>+20.0\u00b19.9<\/strong>\uff0cMMSE\u4e0b\u964d<strong>-9.5 \u00b1 0.7<\/strong>\uff1b\u9ad8\u5242\u91cf\u7ec4ADAS-Cog\u589e\u52a0<strong>+8.6 \u00b1 13.1<\/strong>\uff0cMMSE\u4e0b\u964d<strong>-8.4\u00b15.6<\/strong>\u3002\u6240\u6709\u7ec4\u5185\u4e0e\u7ec4\u95f4\u6bd4\u8f83\u5747<strong>\u65e0\u7edf\u8ba1\u5b66\u663e\u8457\u6027\uff08p &gt; 0.05\uff09<\/strong>\uff0c\u4f46\u9ad8\u5242\u91cf\u7ec4\u7684\u6570\u503c\u6076\u5316\u7a0b\u5ea6\u76f8\u5bf9\u66f4\u8f7b\uff0c\u63d0\u793a\u53ef\u80fd\u5b58\u5728\u5242\u91cf\u76f8\u5173\u7684\u75be\u75c5\u8fdb\u5c55\u5ef6\u7f13\u8d8b\u52bf\u3002<\/p>\n<p>\u540c\u6837\uff0c\u65e5\u5e38\u751f\u6d3b\u80fd\u529b\uff08S-IADL\uff09\u5728\u4e24\u7ec4\u5206\u522b\u6076\u5316<strong>+19.5 \u00b1 6.4<\/strong>respond in singing<strong>+12.0 \u00b1 6.0<\/strong>\uff0c\u4e5f\u65e0\u663e\u8457\u6027\u3002\u5728\u751f\u7269\u5b66\u5c42\u9762\uff0c<strong>PiB-PET\u663e\u793a\u7684\u8111\u5185\u6dc0\u7c89\u6837\u86cb\u767d\u8d1f\u8377\u3001FDG-PET\u6d4b\u91cf\u7684\u8111\u8461\u8404\u7cd6\u4ee3\u8c22\u4ee5\u53ca\u8111\u810a\u6db2\u4e2d\u7684A\u03b2\u3001\u603btau\u548cp-tau\u86cb\u767d\u6c34\u5e73\uff0c\u5728\u6240\u6709\u65f6\u95f4\u70b9\u5747\u672a\u68c0\u6d4b\u5230\u663e\u8457\u53d8\u5316\uff08p &gt; 0.05\uff09<\/strong>The<\/p>\n<h3 id=\"ftoc-heading-6\" class=\"wp-block-heading ftwp-heading\"><span class=\"ez-toc-section\" id=\"%E7%BB%93%E8%AE%BA%E4%B8%8E%E6%9C%AA%E6%9D%A5%E6%96%B9%E5%90%91%EF%BC%9A%E5%AE%89%E5%85%A8%E5%85%88%E4%BE%8B%E4%B8%8E%E6%96%B9%E6%A1%88%E4%BC%98%E5%8C%96\"><\/span>\u7ed3\u8bba\u4e0e\u672a\u6765\u65b9\u5411\uff1a\u5b89\u5168\u5148\u4f8b\u4e0e\u65b9\u6848\u4f18\u5316<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u8be5\u7814\u7a76\u6700\u91cd\u8981\u7684\u8d21\u732e\u5728\u4e8e\uff0c\u9996\u6b21\u7cfb\u7edf\u5730\u8bc1\u5b9e\u4e86\u5728AD\u60a3\u8005\u8111\u5185\u8fdb\u884c\u7acb\u4f53\u5b9a\u5411hUCB-MSCs\u6ce8\u5c04\u7684<strong>\u64cd\u4f5c\u53ef\u884c\u6027\u4e0e\u957f\u671f\u5b89\u5168\u6027<\/strong>\uff0c\u4e3a\u6b64\u540e\u66f4\u6df1\u5165\u7684\u4e34\u5e8a\u7814\u7a76\u6811\u7acb\u4e86\u5173\u952e\u5148\u4f8b\u3002\u7136\u800c\uff0c\u5355\u6b21\u3001\u6709\u9650\u5242\u91cf\u7684\u7ec6\u80de\u6ce8\u5c04\u5e76\u672a\u5728\u8ba4\u77e5\u3001\u529f\u80fd\u6216\u6838\u5fc3AD\u75c5\u7406\u751f\u7269\u6807\u5fd7\u7269\u4e0a\u4ea7\u751f\u53ef\u6d4b\u91cf\u7684\u6cbb\u7597\u6548\u76ca\u3002\u8ba8\u8bba\u90e8\u5206\u5206\u6790\uff0c\u8fd9\u53ef\u80fd\u6e90\u4e8e\u79fb\u690d\u540e\u7ec6\u80de\u5b58\u6d3b\u6709\u9650\u3001\u6076\u52a3\u7684\u8111\u5185\u5fae\u73af\u5883\u4ee5\u53caAD\u590d\u6742\u7684\u75c5\u7406\u673a\u5236\u3002\u57fa\u4e8e\u6b64\uff0c\u7814\u7a76\u8005\u660e\u786e\u6307\u51fa\u672a\u6765\u4f18\u5316\u7684\u6838\u5fc3\u65b9\u5411\uff1a<strong>\u63a2\u7d22\u91cd\u590d\u7ed9\u836f\u65b9\u6848<\/strong>\u3001\u901a\u8fc7<strong>\u57fa\u56e0\u5de5\u7a0b\u6539\u9020\u589e\u5f3aMSCs\u7684\u5b58\u6d3b\u7387\u4e0e\u795e\u7ecf\u8425\u517b\u529f\u80fd<\/strong>\uff0c\u4ee5\u53ca\u5f00\u5c55<strong>\u66f4\u5927\u89c4\u6a21\u3001\u8bbe\u7f6e\u5bf9\u7167\u7684\u4e34\u5e8a\u8bd5\u9a8c<\/strong>\u3002\u8fd9\u9879\u7814\u7a76\u6807\u5fd7\u7740\u7ec6\u80de\u7597\u6cd5\u4ece\u5355\u7eaf\u7684\u5b89\u5168\u9a8c\u8bc1\uff0c\u5411\u8ffd\u6c42\u6709\u6548\u75be\u75c5\u4fee\u9970\u76ee\u6807\u8fc8\u51fa\u4e86\u5fc5\u8981\u7684\u4e00\u6b65\u3002<\/p>\n<h3 id=\"ftoc-heading-7\" class=\"wp-block-heading ftwp-heading\"><span class=\"ez-toc-section\" id=\"%E4%B8%B4%E5%BA%8A%E7%A0%94%E7%A9%B6%E6%A1%88%E4%BE%8B%E4%BA%8C%EF%BC%9A%E2%80%9C%E5%90%91%E9%98%BF%E5%B0%94%E8%8C%A8%E6%B5%B7%E9%BB%98%E7%97%85%E6%82%A3%E8%80%85%E8%84%91%E5%AE%A4%E5%86%85%E6%B3%A8%E5%B0%84%E4%BA%BA%E8%84%90%E5%B8%A6%E8%A1%80%E6%9D%A5%E6%BA%90%E7%9A%84%E9%97%B4%E5%85%85%E8%B4%A8%E5%B9%B2%E7%BB%86%E8%83%9E%EF%BC%9A%E4%B8%80%E9%A1%B91%E6%9C%9F%E4%B8%B4%E5%BA%8A%E8%AF%95%E9%AA%8C%E2%80%9D%EF%BC%88NCT02054208%E5%92%8CNCT03172117%EF%BC%89\"><\/span>\u4e34\u5e8a\u7814\u7a76\u6848\u4f8b\u4e8c\uff1a\u201c\u5411\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u60a3\u8005\u8111\u5ba4\u5185\u6ce8\u5c04\u4eba\u8110\u5e26\u8840\u6765\u6e90\u7684\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff1a\u4e00\u98791\u671f\u4e34\u5e8a\u8bd5\u9a8c\u201d\uff08NCT02054208\u548cNCT03172117\uff09<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<h3 id=\"ftoc-heading-8\" class=\"wp-block-heading ftwp-heading\"><span class=\"ez-toc-section\" id=\"%E5%88%9B%E6%96%B0%E7%9A%84%E9%87%8D%E5%A4%8D%E7%BB%99%E8%8D%AF%E4%B8%8E%E7%B2%BE%E5%87%86%E9%80%92%E9%80%81%E6%96%B9%E6%A1%88\"><\/span>\u521b\u65b0\u7684\u91cd\u590d\u7ed9\u836f\u4e0e\u7cbe\u51c6\u9012\u9001\u65b9\u6848<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>2021\u5e74\uff0ckim\u7b49\u4eba\u201c\u5411\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u60a3\u8005\u8111\u5ba4\u5185\u6ce8\u5c04\u4eba\u8110\u5e26\u8840\u6765\u6e90\u7684\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff1a\u4e00\u98791\u671f\u4e34\u5e8a\u8bd5\u9a8c\u201d\u3002\u672c\u7814\u7a76\u662f\u4e00\u9879\u5f00\u653e\u6807\u7b7e\u3001\u5355\u4e2d\u5fc3\u76841\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u6838\u5fc3\u521b\u65b0\u70b9\u5728\u4e8e\u8bc4\u4f30<strong>\u901a\u8fc7\u9884\u5148\u690d\u5165\u7684Ommaya\u50a8\u6db2\u56ca\uff0c\u5bf9\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\uff08AD\uff09\u60a3\u8005\u8fdb\u884c\u91cd\u590d\u8111\u5ba4\u5185\u6ce8\u5c04\u4eba\u8110\u5e26\u8840\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08hUCB-MSCs\uff0c\u4ea7\u54c1\u540dNEUROSTEM-AD\uff09\u7684\u5b89\u5168\u6027\u4e0e\u53ef\u884c\u6027<\/strong><sup>[2]<\/sup>The<\/p>\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" loading=\"lazy\" width=\"771\" height=\"487\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2026\/01\/20260126171141-69772fcde527d.png\" alt=\"\u5411\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u60a3\u8005\u8111\u5ba4\u5185\u6ce8\u5c04\u4eba\u8110\u5e26\u8840\u6765\u6e90\u7684\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff1a\u4e00\u98791\u671f\u4e34\u5e8a\u8bd5\u9a8c\" class=\"wp-image-58897\" title=\"\u5411\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u60a3\u8005\u8111\u5ba4\u5185\u6ce8\u5c04\u4eba\u8110\u5e26\u8840\u6765\u6e90\u7684\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff1a\u4e00\u98791\u671f\u4e34\u5e8a\u8bd5\u9a8c\"><figcaption class=\"wp-element-caption\">\u5411\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u60a3\u8005\u8111\u5ba4\u5185\u6ce8\u5c04\u4eba\u8110\u5e26\u8840\u6765\u6e90\u7684\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff1a\u4e00\u98791\u671f\u4e34\u5e8a\u8bd5\u9a8c<\/figcaption><\/figure>\n<p>\u7814\u7a76\u5171\u7eb3\u51659\u540d\u5e74\u9f84\u572850-85\u5c81\u3001\u7ecf\u751f\u7269\u6807\u5fd7\u7269\uff08\u6dc0\u7c89\u6837\u86cb\u767dPET\u9633\u6027\uff09\u786e\u8bca\u7684\u8f7b\u5ea6\u81f3\u4e2d\u5ea6AD\u60a3\u8005\uff08MMSE\u8bc4\u520618-26\u5206\uff09\uff0c\u6240\u6709\u60a3\u8005\u5747\u5728\u670d\u7528\u7a33\u5b9a\u7684\u6807\u51c6\u5bf9\u75c7\u836f\u7269\u3002\u60a3\u8005\u88ab\u5206\u4e3a<strong>\u4f4e\u5242\u91cf\u7ec4\uff083\u4eba\uff0c\u6bcf\u6b211.0\u00d710\u2077\u4e2a\u7ec6\u80de\uff09\u548c\u9ad8\u5242\u91cf\u7ec4\uff086\u4eba\uff0c\u6bcf\u6b213.0\u00d710\u2077\u4e2a\u7ec6\u80de\uff09<\/strong>\uff0c\u901a\u8fc7\u50a8\u6db2\u56ca<strong>\u57284\u5468\u95f4\u9694\u5185\u5b8c\u6210\u4e86\u51713\u6b21\u6ce8\u5c04<\/strong>\uff0c\u4e3b\u8981\u968f\u8bbf\u671f\u4e3a12\u5468\u3002\u6b64\u8bbe\u8ba1\u65e8\u5728\u63a2\u7d22\u76f8\u8f83\u4e8e\u5355\u6b21\u7ed9\u836f\uff0c\u91cd\u590d\u7ed9\u836f\u80fd\u5426\u7ef4\u6301\u66f4\u6301\u4e45\u7684\u6cbb\u7597\u6548\u679c\u3002<\/p>\n<h3 id=\"ftoc-heading-9\" class=\"wp-block-heading ftwp-heading\"><span class=\"ez-toc-section\" id=\"%E5%8F%AF%E6%8E%A7%E7%9A%84%E6%80%A5%E6%80%A7%E7%82%8E%E7%97%87%E5%8F%8D%E5%BA%94%E4%B8%8E%E6%98%8E%E7%A1%AE%E7%9A%84%E5%AE%89%E5%85%A8%E6%80%A7\"><\/span>\u53ef\u63a7\u7684\u6025\u6027\u708e\u75c7\u53cd\u5e94\u4e0e\u660e\u786e\u7684\u5b89\u5168\u6027<span 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class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u572812\u5468\u7684\u7597\u6548\u63a2\u7d22\u4e2d\uff0c\u4e34\u5e8a\u8ba4\u77e5\u91cf\u8868\u672a\u663e\u793a\u663e\u8457\u6539\u5584\uff1a<strong>ADAS-Cog\u8bc4\u5206\u6574\u4f53\u6076\u5316+1.8\u00b10.9\uff0cMMSE\u8bc4\u5206\u4ec5\u8f7b\u5fae\u6539\u5584+0.4\u00b10.6<\/strong>\uff08\u5747p&gt;0.05\uff09\uff0c\u4e14\u7ec4\u95f4\u65e0\u5dee\u5f02\uff0c\u529f\u80fd\u91cf\u8868\u4fdd\u6301\u7a33\u5b9a\u3002\u7136\u800c\uff0c\u7814\u7a76\u68c0\u6d4b\u5230\u4e86\u660e\u786e\u7684<strong>\u77ed\u671f\u751f\u7269\u6d3b\u6027\u4fe1\u53f7<\/strong>\uff1a\u8f93\u6ce8\u540e24\u5c0f\u65f6\uff0c\u8111\u810a\u6db2\u4e2dAD\u6838\u5fc3\u75c5\u7406\u86cb\u767d\uff08A\u03b2\u3001\u603btau\u3001p-tau\uff09\u51fa\u73b0\u77ed\u6682\u4e0b\u964d\uff08\u672a\u8fbe\u663e\u8457\u6c34\u5e73\uff09\uff1b\u540c\u65f6\uff0c<strong>\u7531MSCs\u5206\u6ccc\u7684\u6d3b\u6027\u56e0\u5b50\u534a\u4e73\u7cd6\u51dd\u96c6\u7d20-3\u548csICAM-1\u6c34\u5e73\u663e\u8457\u63d0\u5347\uff08\u5206\u522b\u5347\u9ad8\u7ea63\u500d\u548c2\u500d\uff09<\/strong>\uff0c\u8bc1\u5b9e\u79fb\u690d\u7ec6\u80de\u53d1\u6325\u4e86\u4f5c\u7528\u3002\u6b64\u5916\uff0c\u9ad8\u5242\u91cf\u7ec4\u90e8\u5206\u60a3\u8005\u7684\u6dc0\u7c89\u6837\u86cb\u767dPET\u626b\u63cf\u663e\u793a\u51fa\u6807\u51c6\u6444\u53d6\u503c\u6bd4\uff08SUVR\uff09\u964d\u4f4e\u7684\u8d8b\u52bf\uff08p=0.12\uff09\uff0c\u63d0\u793a\u6709\u51cf\u5c11\u6dc0\u7c89\u6837\u86cb\u767d\u8d1f\u8377\u7684\u6f5c\u5728\u53ef\u80fd\u3002\u8fd9\u4e9b\u53d8\u5316\u5747\u57284\u5468\u540e\u56de\u843d\u81f3\u57fa\u7ebf\uff0c\u8868\u660e\u5355\u6b21\u6ce8\u5c04\u7684\u751f\u7269\u6548\u5e94\u6301\u7eed\u65f6\u95f4\u6709\u9650\u3002<\/p>\n<h3 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id=\"ftoc-heading-12\" class=\"wp-block-heading ftwp-heading\"><span class=\"ez-toc-section\" id=\"%E4%B8%B4%E5%BA%8A%E7%A0%94%E7%A9%B6%E6%A1%88%E4%BE%8B%E4%B8%89%EF%BC%9ALomecel-B%E6%B2%BB%E7%96%97%E9%98%BF%E5%B0%94%E8%8C%A8%E6%B5%B7%E9%BB%98%E7%97%85%E7%9A%841%E6%9C%9F%E4%B8%B4%E5%BA%8A%E8%AF%95%E9%AA%8C%E7%BB%93%E6%9E%9C%E5%92%8C%E8%A7%81%E8%A7%A3%E2%80%9D%E3%80%82\"><\/span>\u4e34\u5e8a\u7814\u7a76\u6848\u4f8b\u4e09\uff1aLomecel-B\u6cbb\u7597\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u76841\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u548c\u89c1\u89e3\u201d\u3002<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<h3 id=\"ftoc-heading-13\" class=\"wp-block-heading ftwp-heading\"><span class=\"ez-toc-section\" id=\"%E4%B8%A5%E8%B0%A8%E7%9A%84%E9%9A%8F%E6%9C%BA%E5%8F%8C%E7%9B%B2%E5%AE%89%E6%85%B0%E5%89%82%E5%AF%B9%E7%85%A7%E8%AE%BE%E8%AE%A1\"><\/span>\u4e25\u8c28\u7684\u968f\u673a\u53cc\u76f2\u5b89\u6170\u5242\u5bf9\u7167\u8bbe\u8ba1<span 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src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2026\/01\/20260126171142-69772fce37bb3.png\" alt=\"Lomecel-B\u6cbb\u7597\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u76841\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u548c\u89c1\u89e3\" class=\"wp-image-58895\" title=\"Lomecel-B\u6cbb\u7597\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u76841\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u548c\u89c1\u89e3\"><figcaption class=\"wp-element-caption\">Lomecel-B\u6cbb\u7597\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u76841\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u548c\u89c1\u89e3<\/figcaption><\/figure>\n<p>\u7814\u7a76\u5171\u7eb3\u5165<strong>33\u540d<\/strong>\u5e73\u5747\u5e74\u9f84\u7ea671\u5c81\u7684\u53d7\u8bd5\u8005\uff0c\u6309<strong>1:1:1<\/strong>\u7684\u6bd4\u4f8b\u968f\u673a\u5206\u4e3a\u4e09\u7ec4\uff1a<strong>\u4f4e\u5242\u91cf\u7ec4\uff08\u5355\u6b21\u9759\u8109\u8f93\u6ce82\u00d710\u2077\u4e2a\u7ec6\u80de\uff09\u3001\u9ad8\u5242\u91cf\u7ec4\uff081\u00d710\u2078\u4e2a\u7ec6\u80de\uff09\u4ee5\u53ca\u5b89\u6170\u5242\u7ec4<\/strong>\u3002\u6240\u6709\u53d7\u8bd5\u8005\u5747\u7ecf\u4e34\u5e8a\u8bc4\u4f30\u3001\u8111\u90e8MRI\u53ca\u6dc0\u7c89\u6837\u86cb\u767dPET\u6210\u50cf\u786e\u8bca\uff0c\u57fa\u7ebf\u5e73\u5747\u7b80\u6613\u7cbe\u795e\u72b6\u6001\u68c0\u67e5\u91cf\u8868\uff08MMSE\uff09\u8bc4\u5206\u7ea6\u4e3a20\u5206\u3002\u7814\u7a76\u91c7\u7528\u5355\u6b21\u7ed9\u836f\uff0c\u5e76\u8fdb\u884c\u4e86\u957f\u8fbe<strong>52\u5468<\/strong>\u7684\u968f\u8bbf\uff0c\u4e3b\u8981\u7ec8\u70b9\u4e3a\u5b89\u5168\u6027\uff0c\u540c\u65f6\u591a\u7ef4\u5ea6\u63a2\u7d22\u4e86\u7597\u6548\u4fe1\u53f7\u3002<\/p>\n<h3 id=\"ftoc-heading-14\" class=\"wp-block-heading ftwp-heading\"><span class=\"ez-toc-section\" id=\"%E8%89%AF%E5%A5%BD%E7%9A%84%E5%AE%89%E5%85%A8%E6%80%A7%E4%B8%8E%E8%80%90%E5%8F%97%E6%80%A7%E8%AE%B0%E5%BD%95\"><\/span>\u826f\u597d\u7684\u5b89\u5168\u6027\u4e0e\u8010\u53d7\u6027\u8bb0\u5f55<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u5b89\u5168\u6027\u7ed3\u679c\u663e\u793a\uff0cLomecel-B\u5355\u6b21\u9759\u8109\u8f93\u6ce8\u5728\u8f7b\u5ea6AD\u60a3\u8005\u4e2d<strong>\u5b89\u5168\u4e14\u8010\u53d7\u6027\u826f\u597d<\/strong>\u3002\u6574\u4e2a\u7814\u7a76\u671f\u95f4<strong>\u672a\u53d1\u751f\u4e0e\u6cbb\u7597\u76f4\u63a5\u76f8\u5173\u7684\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\uff08SAE\uff09<\/strong>\u3002\u62a5\u544a\u7684\u4e0d\u826f\u4e8b\u4ef6\uff08AE\uff09\u901a\u5e38\u4e3a\u8f7b\u5fae\u3001\u77ed\u6682\u7684\u75c7\u72b6\uff0c\u5982\u75b2\u52b3\u3001\u5934\u75db\u548c\u6076\u5fc3\u3002\u552f\u4e00\u4e00\u4f8b\u9700\u4f4f\u9662\u7684SAE\uff08\u80cc\u75db\uff09\u53d1\u751f\u5728\u9ad8\u5242\u91cf\u7ec4\uff0c\u4f46\u88ab\u8bc4\u4f30\u4e3a\u4e0e\u6cbb\u7597\u65e0\u5173\u3002\u4e00\u4e2a\u5173\u952e\u7684\u5b89\u5168\u53d1\u73b0\u662f\uff0c<strong>\u6240\u6709\u53d7\u8bd5\u8005\u5747\u672a\u68c0\u6d4b\u5230\u6dc0\u7c89\u6837\u86cb\u767d\u76f8\u5173\u5f71\u50cf\u5b66\u5f02\u5e38\uff08ARIA\uff09<\/strong>\u2014\u2014\u8fd9\u662f\u76ee\u524d\u9488\u5bf9AD\u75c5\u7406\u7684\u6297\u4f53\u836f\u7269\u5e38\u89c1\u4e14\u9700\u91cd\u70b9\u76d1\u6d4b\u7684\u98ce\u9669\u3002\u5b9a\u671f\u5b9e\u9a8c\u5ba4\u68c0\u67e5\u548c\u751f\u547d\u4f53\u5f81\u76d1\u6d4b\u4e5f\u672a\u663e\u793a\u4e0e\u6cbb\u7597\u76f8\u5173\u7684\u5f02\u5e38\u8d8b\u52bf\u3002<\/p>\n<h3 id=\"ftoc-heading-15\" class=\"wp-block-heading ftwp-heading\"><span class=\"ez-toc-section\" id=\"%E5%A4%9A%E7%BB%B4%E5%BA%A6%E7%96%97%E6%95%88%E4%BF%A1%E5%8F%B7%EF%BC%9A%E8%AE%A4%E7%9F%A5%E3%80%81%E7%BB%93%E6%9E%84%E4%B8%8E%E7%94%9F%E7%89%A9%E6%A0%87%E5%BF%97%E7%89%A9\"><\/span>\u591a\u7ef4\u5ea6\u7597\u6548\u4fe1\u53f7\uff1a\u8ba4\u77e5\u3001\u7ed3\u6784\u4e0e\u751f\u7269\u6807\u5fd7\u7269<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u5c3d\u7ba1\u6837\u672c\u91cf\u6709\u9650\uff0c\u4f46\u7814\u7a76\u5728\u591a\u4e2a\u7ef4\u5ea6\u68c0\u6d4b\u5230\u4e86\u79ef\u6781\u7684\u63a2\u7d22\u6027\u7597\u6548\u4fe1\u53f7\uff0c\u5c24\u5176\u5728<strong>\u4f4e\u5242\u91cf\u7ec4<\/strong>\u8868\u73b0\u66f4\u4e3a\u4e00\u81f4\uff1a<\/p>\n<ul class=\"wp-block-list\">\n<li><strong>\u8ba4\u77e5\u4e0e\u751f\u6d3b\u8d28\u91cf<\/strong>\uff1a\u5728<strong>13\u5468<\/strong>\u65f6\uff0c<strong>\u4f4e\u5242\u91cf\u7ec4MMSE\u8bc4\u5206\u8f83\u5b89\u6170\u5242\u7ec4\u9ad8\u51fa2.7\u5206\uff08p=0.0182\uff09<\/strong>\uff0c\u663e\u793a\u51fa\u8ba4\u77e5\u4e0b\u964d\u901f\u5ea6\u7684\u51cf\u7f13\uff0c\u6b64\u4f18\u52bf\u6301\u7eed\u81f326\u5468\u3002\u540c\u65f6\uff0c\u4f4e\u5242\u91cf\u7ec4\u572826\u5468\u65f6<strong>\u751f\u6d3b\u8d28\u91cf\u8bc4\u5206\uff08QOL-AD\uff09\u8f83\u5b89\u6170\u5242\u7ec4\u663e\u8457\u63d0\u9ad83.85\u5206\uff08p=0.0444\uff09<\/strong>The<\/li>\n<li><strong>\u8111\u7ed3\u6784\u5f71\u50cf<\/strong>::<strong>\u9ad8\u5242\u91cf\u7ec4<\/strong>\u572813\u5468\u65f6\u89c2\u5bdf\u5230<strong>\u5de6\u4fa7\u6d77\u9a6c\u4f53\u79ef\u51fa\u73b0\u77ed\u6682\u6027\u589e\u52a0\uff08p=0.0311\uff09<\/strong>\uff0c\u63d0\u793a\u6f5c\u5728\u7684\u795e\u7ecf\u4fdd\u62a4\u4f5c\u7528\uff0c\u4f46\u8be5\u6548\u5e94\u672a\u5728\u540e\u7eed\u65f6\u95f4\u70b9\u6301\u7eed\u3002<\/li>\n<li><strong>\u5916\u5468\u751f\u7269\u6807\u5fd7\u7269<\/strong>\uff1a\u6cbb\u7597\u7ec4\uff08\u7279\u522b\u662f\u9ad8\u5242\u91cf\u7ec4\uff09\u7684\u5916\u5468\u8840\u663e\u793a<strong>\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\uff08VEGF\uff09\u548c\u6297\u708e\u7ec6\u80de\u56e0\u5b50\uff08\u5982IL-4\u3001IL-10\uff09\u6c34\u5e73\u663e\u8457\u5347\u9ad8<\/strong>\uff0c\u8868\u660e\u6cbb\u7597\u53ef\u80fd\u6539\u5584\u4e86\u8840\u7ba1\u529f\u80fd\u5e76\u8c03\u8282\u4e86\u795e\u7ecf\u708e\u75c7\u3002<\/li>\n<\/ul>\n<h3 id=\"ftoc-heading-16\" class=\"wp-block-heading ftwp-heading\"><span class=\"ez-toc-section\" id=\"%E7%BB%93%E8%AE%BA%E4%B8%8E%E5%90%AF%E7%A4%BA%EF%BC%9A%E4%BD%8E%E5%89%82%E9%87%8F%E4%BC%98%E5%8A%BF%E4%B8%8E%E6%9C%AA%E6%9D%A5%E6%96%B9%E5%90%91\"><\/span>\u7ed3\u8bba\u4e0e\u542f\u793a\uff1a\u4f4e\u5242\u91cf\u4f18\u52bf\u4e0e\u672a\u6765\u65b9\u5411<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u672c\u7814\u7a76\u4e3a\u9759\u8109\u8f93\u6ce8LMSCs\u6cbb\u7597\u8f7b\u5ea6AD\u63d0\u4f9b\u4e86\u8fc4\u4eca\u6700\u4e25\u8c28\u7684\u65e9\u671f\u4e34\u5e8a\u8bc1\u636e\u3002\u5176\u6838\u5fc3\u53d1\u73b0\u63d0\u793a\uff0c<strong>\u4f4e\u5242\u91cf\uff082\u00d710\u2077\u4e2a\u7ec6\u80de\uff09\u5355\u6b21\u8f93\u6ce8\u53ef\u80fd\u5728\u51cf\u7f13\u8ba4\u77e5\u8870\u9000\u3001\u6539\u5584\u751f\u6d3b\u8d28\u91cf\u65b9\u9762\u5177\u6709\u66f4\u4f18\u7684\u6f5c\u529b<\/strong>\uff0c\u800c\u9ad8\u5242\u91cf\u7ec4\u672a\u663e\u793a\u4e00\u81f4\u4f18\u52bf\uff0c\u8fd9\u53ef\u80fd\u4e0e\u5242\u91cf\u53cd\u5e94\u590d\u6742\u6027\u6709\u5173\u3002\u8be5\u7814\u7a76\u4e0d\u4ec5\u8bc1\u5b9e\u4e86\u826f\u597d\u7684\u5b89\u5168\u6027\uff0c\u66f4\u901a\u8fc7\u8ba4\u77e5\u91cf\u8868\u3001\u5f71\u50cf\u5b66\u548c\u5206\u5b50\u751f\u7269\u6807\u5fd7\u7269\u7b49\u591a\u91cd\u8bc1\u636e\uff0c\u4e3aMSCs\u7684\u75be\u75c5\u4fee\u9970\u6f5c\u529b\u63d0\u4f9b\u4e86\u652f\u6301\u3002\u57fa\u4e8e\u8fd9\u4e9b\u9f13\u821e\u6027\u7ed3\u679c\uff0c\u7814\u7a76\u8005\u5df2\u542f\u52a8\u4e00\u9879\u66f4\u5927\u89c4\u6a21\u7684IIa\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08NCT05233774\uff09\uff0c\u4ee5\u8fdb\u4e00\u6b65\u9a8c\u8bc1\u7597\u6548\u5e76\u63a2\u7d22\u91cd\u590d\u7ed9\u836f\u7684\u65b9\u6848\u3002<\/p>\n<h3 id=\"ftoc-heading-17\" class=\"wp-block-heading ftwp-heading\"><span class=\"ez-toc-section\" id=\"%E4%B8%B4%E5%BA%8A%E7%A0%94%E7%A9%B6%E6%A1%88%E4%BE%8B%E5%9B%9B%EF%BC%9Alarmestrocel%E6%B2%BB%E7%96%97%E8%BD%BB%E5%BA%A6%E9%98%BF%E5%B0%94%E8%8C%A8%E6%B5%B7%E9%BB%98%E7%97%85%E7%9A%84%E5%90%8C%E7%A7%8D%E5%BC%82%E4%BD%93%E9%97%B4%E5%85%85%E8%B4%A8%E5%B9%B2%E7%BB%86%E8%83%9E%E7%96%97%E6%B3%95%EF%BC%9A%E4%B8%80%E9%A1%B9%E9%9A%8F%E6%9C%BA%E5%AF%B9%E7%85%A72a%E6%9C%9F%E8%AF%95%E9%AA%8C%E2%80%9D%E3%80%82\"><\/span>\u4e34\u5e8a\u7814\u7a76\u6848\u4f8b\u56db\uff1alarmestrocel\u6cbb\u7597\u8f7b\u5ea6\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u540c\u79cd\u5f02\u4f53\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u7597\u6cd5\uff1a\u4e00\u9879\u968f\u673a\u5bf9\u71672a\u671f\u8bd5\u9a8c\u201d\u3002<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<h3 id=\"ftoc-heading-18\" class=\"wp-block-heading ftwp-heading\"><span class=\"ez-toc-section\" id=\"%E8%BF%9B%E9%98%B6%E7%9A%84%E9%9A%8F%E6%9C%BA%E5%AF%B9%E7%85%A7%E4%B8%8E%E5%A4%9A%E5%89%82%E9%87%8F%E6%96%B9%E6%A1%88%E8%AE%BE%E8%AE%A1\"><\/span>\u8fdb\u9636\u7684\u968f\u673a\u5bf9\u7167\u4e0e\u591a\u5242\u91cf\u65b9\u6848\u8bbe\u8ba1<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>2025\u5e74\uff0cRash\u7b49\u4eba\u4f7f\u7528\u201dlarmestrocel\u6cbb\u7597\u8f7b\u5ea6\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u540c\u79cd\u5f02\u4f53\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u7597\u6cd5\uff1a\u4e00\u9879\u968f\u673a\u5bf9\u71672a\u671f\u8bd5\u9a8c\u201d\uff08NCT05233774\uff09\u3002\u672c\u7814\u7a76\uff08CLEAR-MIND\u8bd5\u9a8c\uff09\u662f\u4e00\u9879\u8bbe\u8ba1\u66f4\u4e3a\u590d\u6742\u548c\u6df1\u5165\u7684<strong>IIa\u671f\u3001\u591a\u4e2d\u5fc3\u3001\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167<\/strong>\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u65e8\u5728\u7cfb\u7edf\u8bc4\u4f30\u4e0d\u540c\u7ed9\u836f\u65b9\u6848\u4e0bLomecel-B\u6cbb\u7597\u8f7b\u5ea6\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\uff08AD\uff09\u7684\u7597\u6548\u3002\u7814\u7a76\u5171\u7eb3\u5165<strong>50\u540d<\/strong>\u5e73\u5747\u5e74\u9f84\u7ea674\u5c81\u3001\u7ecf\u6dc0\u7c89\u6837\u86cb\u767dPET\u786e\u8ba4\u7684\u8f7b\u5ea6AD\u60a3\u8005<sup>[4]<\/sup>The<\/p>\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" loading=\"lazy\" width=\"752\" height=\"446\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2026\/01\/20260126171142-69772fce52612.png\" alt=\"larmestrocel\u6cbb\u7597\u8f7b\u5ea6\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u540c\u79cd\u5f02\u4f53\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u7597\u6cd5\uff1a\u4e00\u9879\u968f\u673a\u5bf9\u71672a\u671f\u8bd5\u9a8c\" class=\"wp-image-58894\" title=\"larmestrocel\u6cbb\u7597\u8f7b\u5ea6\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u540c\u79cd\u5f02\u4f53\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u7597\u6cd5\uff1a\u4e00\u9879\u968f\u673a\u5bf9\u71672a\u671f\u8bd5\u9a8c\"><figcaption class=\"wp-element-caption\">larmestrocel\u6cbb\u7597\u8f7b\u5ea6\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u540c\u79cd\u5f02\u4f53\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u7597\u6cd5\uff1a\u4e00\u9879\u968f\u673a\u5bf9\u71672a\u671f\u8bd5\u9a8c<\/figcaption><\/figure>\n<p>\u5173\u952e\u521b\u65b0\u5728\u4e8e\u5176<strong>\u56db\u7ec4\u3001\u591a\u5242\u91cf\u3001\u591a\u6b21\u7ed9\u836f<\/strong>\u7684\u8bbe\u8ba1\uff1a\u60a3\u8005\u4ee51:1:1:1\u6bd4\u4f8b\u968f\u673a\u5206\u5165<strong>\u5b89\u6170\u5242\u7ec4\uff084\u6b21\u8f93\u6ce8\uff09\u30011\u00d7\u4f4e\u5242\u91cf\u7ec4\uff08\u5355\u6b212.5\u00d710\u2077\u7ec6\u80de+3\u6b21\u5b89\u6170\u5242\uff09\u30014\u00d7\u4f4e\u5242\u91cf\u7ec4\uff084\u6b21\u8f93\u6ce8\uff0c\u6bcf\u6b212\u00d710\u2077\u7ec6\u80de\uff09\u548c4\u00d7\u9ad8\u5242\u91cf\u7ec4\uff084\u6b21\u8f93\u6ce8\uff0c\u6bcf\u6b211\u00d710\u2078\u7ec6\u80de\uff09<\/strong>\u3002\u7814\u7a76\u6301\u7eed<strong>39\u5468<\/strong>\uff0c\u5728\u591a\u4e2a\u65f6\u95f4\u70b9\u8fdb\u884c\u7efc\u5408\u8bc4\u4f30\uff0c\u5176\u6838\u5fc3\u76ee\u6807\u662f\u8d85\u8d8a\u5355\u7eaf\u7684\u5b89\u5168\u6027\u9a8c\u8bc1\uff0c\u521d\u6b65\u63a2\u7d22\u7597\u6548\u4fe1\u53f7\u548c\u6700\u4f18\u7ed9\u836f\u7b56\u7565\u3002<\/p>\n<h3 id=\"ftoc-heading-19\" class=\"wp-block-heading ftwp-heading\"><span class=\"ez-toc-section\" id=\"%E4%BC%98%E5%BC%82%E7%9A%84%E5%AE%89%E5%85%A8%E6%80%A7%EF%BC%9A%E6%97%A0ARIA%E9%A3%8E%E9%99%A9%E6%98%AF%E7%AA%81%E5%87%BA%E4%BA%AE%E7%82%B9\"><\/span>\u4f18\u5f02\u7684\u5b89\u5168\u6027\uff1a\u65e0ARIA\u98ce\u9669\u662f\u7a81\u51fa\u4eae\u70b9<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u8bd5\u9a8c\u7ed3\u679c\u518d\u6b21\u8bc1\u5b9e\u5e76\u5f3a\u5316\u4e86Lomecel-B<strong>\u5353\u8d8a\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027<\/strong>\u3002\u5728\u6240\u6709\u6cbb\u7597\u7ec4\u4e2d\uff0c<strong>\u672a\u53d1\u751f\u4efb\u4f55\u8f93\u6ce8\u76f8\u5173\u53cd\u5e94\u3001\u8d85\u654f\u53cd\u5e94\u6216\u6dc0\u7c89\u6837\u86cb\u767d\u76f8\u5173\u5f71\u50cf\u5b66\u5f02\u5e38\uff08ARIA\uff09\u75c5\u4f8b<\/strong>\u3002\u8003\u8651\u5230\u7814\u7a76\u4e2d\u5305\u542b\u4e86APOE 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id=\"%E7%A7%AF%E6%9E%81%E7%9A%84%E7%96%97%E6%95%88%E4%BF%A1%E5%8F%B7%EF%BC%9A%E8%AE%A4%E7%9F%A5%E3%80%81%E5%8A%9F%E8%83%BD%E4%B8%8E%E8%84%91%E7%BB%93%E6%9E%84%E7%9A%84%E6%94%B9%E5%96%84\"><\/span>\u79ef\u6781\u7684\u7597\u6548\u4fe1\u53f7\uff1a\u8ba4\u77e5\u3001\u529f\u80fd\u4e0e\u8111\u7ed3\u6784\u7684\u6539\u5584<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u5c3d\u7ba1\u6837\u672c\u91cf\u6240\u9650\uff0c\u63a2\u7d22\u6027\u5206\u6790\u63ed\u793a\u4e86\u591a\u65b9\u9762\u5177\u6709\u7edf\u8ba1\u5b66\u610f\u4e49\u7684\u79ef\u6781\u4fe1\u53f7\uff1a<\/p>\n<ul class=\"wp-block-list\">\n<li><strong>\u8ba4\u77e5\u4e0e\u529f\u80fd<\/strong>::<strong>1\u00d7\u4f4e\u5242\u91cf\u7ec4<\/strong>\u572839\u5468\u65f6<strong>\u8499\u7279\u5229\u5c14\u8ba4\u77e5\u8bc4\u4f30\u91cf\u8868\uff08MoCA\uff09\u8bc4\u5206\u8f83\u5b89\u6170\u5242\u7ec4\u6709\u663e\u8457\u6539\u5584\uff08p=0.009\uff09<\/strong>The<strong>4\u00d7\u9ad8\u5242\u91cf\u7ec4<\/strong>\u5728\u5de5\u5177\u6027\u65e5\u5e38\u751f\u6d3b\u80fd\u529b\uff08ADCS-ADL\uff09\u4e0a\u7684\u8868\u73b0\u4e5f\u663e\u8457\u4f18\u4e8e\u5b89\u6170\u5242\u7ec4\uff08p=0.040\uff09\u3002<\/li>\n<li><strong>\u8111\u7ed3\u6784\u4fdd\u62a4\uff08\u6838\u5fc3\u53d1\u73b0\uff09<\/strong>\uff1aMRI\u5f71\u50cf\u5b66\u63d0\u4f9b\u4e86\u6700\u6709\u529b\u7684\u75be\u75c5\u4fee\u9970\u8bc1\u636e\u3002\u4e0e\u5b89\u6170\u5242\u7ec4\u76f8\u6bd4\uff0c<strong>4\u00d7\u4f4e\u5242\u91cf\u7ec4\u548c4\u00d7\u9ad8\u5242\u91cf\u7ec4\u7684\u5168\u8111\u840e\u7f29\u7387\u663e\u8457\u964d\u4f4e\uff08p\u503c\u5206\u522b\u4e3a0.006\u548c0.009\uff09<\/strong>\u3002\u540c\u65f6\uff0c<strong>\u6240\u6709\u6cbb\u7597\u7ec4\uff081\u00d7\u4f4e\u30014\u00d7\u4f4e\u53ca\u5408\u5e76\u7ec4\uff09\u7684\u53cc\u4fa7\u6d77\u9a6c\u840e\u7f29\u4e5f\u663e\u8457\u51cf\u5c11\uff08p\u503c\u8303\u56f40.013-0.029\uff09<\/strong>\u3002\u9ad8\u5242\u91cf\u7ec4\u8fd8\u5728\u7279\u5b9a\u8111\u533a\uff08\u5982\u5de6\u4fa7\u5185\u4fa7\u989e\u53f6\uff09\u663e\u793a\u51fa\u66f4\u663e\u8457\u7684\u840e\u7f29\u51cf\u7f13\u3002<\/li>\n<li><strong>\u673a\u5236\u6027\u751f\u7269\u6807\u5fd7\u7269<\/strong>\uff1a\u5f25\u6563\u5f20\u91cf\u6210\u50cf\uff08DTI\uff09\u63d0\u793a\u6cbb\u7597\u7ec4\u795e\u7ecf\u708e\u75c7\u51cf\u8f7b\uff08\u59821\u00d7\u4f4e\u5242\u91cf\u7ec4\u6263\u5e26\u56de\u5e73\u5747\u5f25\u6563\u7387\u964d\u4f4e\uff0cp=0.048\uff09\u3002\u8840\u6e05\u4e2d\u53cd\u6620\u5185\u76ae\u529f\u80fd\u969c\u788d\u7684\u6807\u5fd7\u7269<strong>sTIE2\u57284\u00d7\u4f4e\u5242\u91cf\u7ec4\u591a\u4e2a\u65f6\u95f4\u70b9\u663e\u8457\u964d\u4f4e\uff08\u5982\u7b2c4\u5468p=0.01\uff09<\/strong>\uff0c\u63d0\u793a\u8840\u7ba1\u529f\u80fd\u5f97\u5230\u6539\u5584\u3002<\/li>\n<\/ul>\n<h3 id=\"ftoc-heading-21\" class=\"wp-block-heading ftwp-heading\"><span class=\"ez-toc-section\" id=\"%E7%BB%93%E8%AE%BA%E4%B8%8E%E5%B1%95%E6%9C%9B%EF%BC%9A%E7%A1%AE%E7%AB%8B%E7%96%BE%E7%97%85%E4%BF%AE%E9%A5%B0%E6%BD%9C%E5%8A%9B%E4%B8%8E%E4%BC%98%E5%8C%96%E7%BB%99%E8%8D%AF%E7%AD%96%E7%95%A5\"><\/span>\u7ed3\u8bba\u4e0e\u5c55\u671b\uff1a\u786e\u7acb\u75be\u75c5\u4fee\u9970\u6f5c\u529b\u4e0e\u4f18\u5316\u7ed9\u836f\u7b56\u7565<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u672c\u9879IIa\u671f\u7814\u7a76\u6807\u5fd7\u7740\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6cbb\u7597AD\u4ece\u5b89\u5168\u6027\u63a2\u7d22\u8fc8\u5411\u4e86\u521d\u6b65\u7597\u6548\u9a8c\u8bc1\u7684\u65b0\u9636\u6bb5\u3002\u5176\u6838\u5fc3\u4ef7\u503c\u5728\u4e8e\uff0c\u901a\u8fc7\u4e25\u8c28\u7684\u5bf9\u7167\u8bbe\u8ba1\uff0c\u9996\u6b21\u63d0\u4f9b\u4e86<strong>Lomecel-B\u53ef\u80fd\u5177\u6709\u51cf\u7f13\u8111\u7ed3\u6784\u840e\u7f29\uff08\u5168\u8111\u53ca\u6d77\u9a6c\uff09\u8fd9\u4e00\u75be\u75c5\u4fee\u9970\u4f5c\u7528\u7684\u76f4\u63a5\u5f71\u50cf\u5b66\u8bc1\u636e<\/strong>\u3002\u540c\u65f6\uff0c\u5176<strong>\u5b8c\u5168\u65e0ARIA\u98ce\u9669\u7684\u5b89\u5168\u7279\u6027<\/strong>\uff0c\u4f7f\u5176\u53ef\u80fd\u6210\u4e3a\u73b0\u6709\u6297\u4f53\u7597\u6cd5\uff08\u5c24\u5176\u5bf9APOE \u03b54\u643a\u5e26\u8005\uff09\u7684\u66f4\u5b89\u5168\u66ff\u4ee3\u6216\u8865\u5145\u3002\u7814\u7a76\u4e5f\u63d0\u793a\u4e86\u7ed9\u836f\u7b56\u7565\u7684\u91cd\u8981\u6027\uff1a<strong>\u5355\u6b21\u4f4e\u5242\u91cf\u8f93\u6ce8\u5728\u90e8\u5206\u8ba4\u77e5\u6307\u6807\u4e0a\u8868\u73b0\u7a81\u51fa\uff0c\u800c\u591a\u6b21\u8f93\u6ce8\uff08\u5c24\u5176\u662f\u9ad8\u5242\u91cf\uff09\u5728\u4fdd\u62a4\u8111\u7ed3\u6784\u548c\u7ef4\u6301\u529f\u80fd\u65b9\u9762\u66f4\u5177\u4f18\u52bf<\/strong>\u3002\u8fd9\u4e9b\u7ed3\u679c\u4e3a\u540e\u7eed\u5f00\u5c55\u5927\u89c4\u6a21III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4ee5\u786e\u8bc1\u7597\u6548\u3001\u5e76\u6700\u7ec8\u786e\u5b9a\u6700\u4f18\u7ed9\u836f\u65b9\u6848\uff08\u5242\u91cf\u3001\u9891\u7387\uff09\u5960\u5b9a\u4e86\u575a\u5b9e\u7684\u57fa\u7840\u3002<\/p>\n<h3 id=\"ftoc-heading-22\" class=\"wp-block-heading ftwp-heading\"><span class=\"ez-toc-section\" id=\"%E4%B8%B4%E5%BA%8A%E7%A0%94%E7%A9%B6%E6%A1%88%E4%BE%8B%E4%BA%94%EF%BC%9AAstroStem%E6%B2%BB%E7%96%97%E9%98%BF%E5%B0%94%E8%8C%A8%E6%B5%B7%E9%BB%98%E7%97%85%E5%AE%89%E5%85%A8%E6%80%A7%E5%92%8C%E6%9C%89%E6%95%88%E6%80%A7%E7%9A%84%E7%A0%94%E7%A9%B6%E3%80%82\"><\/span>\u4e34\u5e8a\u7814\u7a76\u6848\u4f8b\u4e94\uff1aAstroStem\u6cbb\u7597\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u7684\u7814\u7a76\u3002<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<h3 id=\"ftoc-heading-23\" class=\"wp-block-heading ftwp-heading\"><span class=\"ez-toc-section\" id=\"%E9%95%BF%E5%91%A8%E6%9C%9F%E3%80%81%E9%AB%98%E5%BC%BA%E5%BA%A6%E7%9A%84%E8%87%AA%E4%BD%93%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E8%AE%BE%E8%AE%A1\"><\/span>\u957f\u5468\u671f\u3001\u9ad8\u5f3a\u5ea6\u7684\u81ea\u4f53\u7ec6\u80de\u6cbb\u7597\u8bbe\u8ba1<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>2021\u5e74\uff0c\u8fdb\u884c\u4e86\u4e00\u9879\u8bc4\u4f30AstroStem\u6cbb\u7597\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u7684\u7814\u7a76\u3002\u672c\u7814\u7a76\u662f\u4e00\u9879<strong>\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u7684I\/II\u671f\u4e34\u5e8a\u8bd5\u9a8c<\/strong>\uff0c\u63a2\u7d22\u4e86<strong>\u81ea\u4f53\u8102\u80aa\u6765\u6e90\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08AdMSCs\uff09<\/strong>\u00a0\u6cbb\u7597\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\uff08AD\uff09\u7684\u5b89\u5168\u6027\u4e0e\u6709\u6548\u6027<sup>[5]<\/sup>The<\/p>\n<p>\u7814\u7a76\u5171\u7eb3\u5165<strong>31\u540d<\/strong>\u60a3\u8005\uff0c\u5176\u4e2d<strong>21\u540d<\/strong>\u88ab\u5206\u914d\u81f3\u6cbb\u7597\u7ec4\uff0c<strong>10\u540d<\/strong>\u5206\u914d\u81f3\u5b89\u6170\u5242\u7ec4\u3002\u6cbb\u7597\u65b9\u6848\u5f3a\u5ea6\u8f83\u9ad8\uff1a\u6cbb\u7597\u7ec4\u60a3\u8005<strong>\u6bcf2\u5468\u63a5\u53d7\u4e00\u6b21\u9759\u8109\u8f93\u6ce8\uff0c\u6bcf\u6b21\u5242\u91cf\u4e3a2\u00d710\u2078\u4e2a\u7ec6\u80de\uff0c\u572818\u5468\u5185\u5171\u5b8c\u62109\u6b21\u8f93\u6ce8<\/strong>\u3002\u5b89\u6170\u5242\u5219\u4e3a\u542b30%\u81ea\u4f53\u8840\u6e05\u7684\u751f\u7406\u76d0\u6c34\u3002\u7814\u7a76\u7684\u4e3b\u8981\u968f\u8bbf\u89c2\u5bdf\u671f\u957f\u8fbe<strong>52\u5468<\/strong>\uff0c\u65e8\u5728\u8bc4\u4f30\u8fd9\u79cd\u957f\u671f\u3001\u91cd\u590d\u7ed9\u836f\u7b56\u7565\u7684\u6548\u679c\u3002<\/p>\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" loading=\"lazy\" width=\"1359\" height=\"400\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2026\/01\/20260126171142-69772fce72039.png\" alt=\"\u4e00\u9879\u8bc4\u4f30AstroStem\u6cbb\u7597\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u7684\u7814\u7a76\" class=\"wp-image-58893\" title=\"\u4e00\u9879\u8bc4\u4f30AstroStem\u6cbb\u7597\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u7684\u7814\u7a76\"><figcaption class=\"wp-element-caption\">\u4e00\u9879\u8bc4\u4f30AstroStem\u6cbb\u7597\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u7684\u7814\u7a76<\/figcaption><\/figure>\n<h3 id=\"ftoc-heading-24\" class=\"wp-block-heading ftwp-heading\"><span class=\"ez-toc-section\" id=\"%E5%AE%89%E5%85%A8%E6%80%A7%E6%80%BB%E4%BD%93%E5%8F%AF%E6%8E%A5%E5%8F%97%EF%BC%8C%E4%BD%86%E5%AD%98%E5%9C%A8%E4%B8%A5%E9%87%8D%E4%B8%8D%E8%89%AF%E4%BA%8B%E4%BB%B6%E6%8A%A5%E5%91%8A\"><\/span>\u5b89\u5168\u6027\u603b\u4f53\u53ef\u63a5\u53d7\uff0c\u4f46\u5b58\u5728\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\u62a5\u544a<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u5b89\u5168\u6027\u7ed3\u679c\u663e\u793a\uff0cAdMSCs\u7684\u91cd\u590d\u8f93\u6ce8\u603b\u4f53\u4e0a\u88ab\u60a3\u8005\u8010\u53d7\u3002<strong>\u6cbb\u7597\u7ec4\u4e0e\u5b89\u6170\u5242\u7ec4\u7684\u6cbb\u7597\u671f\u95f4\u51fa\u73b0\u7684\u4e0d\u826f\u4e8b\u4ef6\uff08TE-AE\uff09\u53d1\u751f\u7387\u76f8\u4f3c<\/strong>\uff08\u6cbb\u7597\u7ec421\u4eba\u4e2d\u768411\u4eba vs. \u5b89\u6170\u5242\u7ec410\u4eba\u4e2d\u76843\u4eba\uff09\u3002<strong>\u672a\u62a5\u544a\u5242\u91cf\u9650\u5236\u6027\u6bd2\u6027\uff08DLT\uff09<\/strong>\uff0c\u5927\u591a\u6570\u4e0d\u826f\u4e8b\u4ef6\u4e3a\u8f7b\u5ea6\u81f3\u4e2d\u5ea6\u3002\u7136\u800c\uff0c\u6cbb\u7597\u7ec4\u62a5\u544a\u4e86<strong>3\u4f8b\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\uff08SAE\uff09<\/strong>\uff0c\u5206\u522b\u4e3a\u8179\u6cfb\u3001IV\u671f\u98df\u7ba1\u9cde\u72b6\u7ec6\u80de\u764c\u548c\u80ba\u6813\u585e\u3002\u7814\u7a76\u8005\u8bc4\u4f30\u8ba4\u4e3a\uff0c\u8fd9\u4e9bSAE\u5747<strong>\u4e0eAdMSCs\u8f93\u6ce8\u6cbb\u7597\u65e0\u5173<\/strong>\u3002\u5176\u4ed6\u975e\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\u5305\u62ec\u75b2\u4e4f\u3001\u4f53\u91cd\u51cf\u8f7b\u7b49\u3002<\/p>\n<h3 id=\"ftoc-heading-25\" class=\"wp-block-heading ftwp-heading\"><span class=\"ez-toc-section\" id=\"%E7%96%97%E6%95%88%E7%BB%93%E6%9E%9C%E6%9C%AA%E6%98%BE%E7%A4%BA%E7%A7%AF%E6%9E%81%E4%BF%A1%E5%8F%B7%EF%BC%8C%E8%AE%A4%E7%9F%A5%E4%B8%8B%E9%99%8D%E8%B6%8B%E5%8A%BF%E6%9B%B4%E4%B8%BA%E6%98%8E%E6%98%BE\"><\/span>\u7597\u6548\u7ed3\u679c\u672a\u663e\u793a\u79ef\u6781\u4fe1\u53f7\uff0c\u8ba4\u77e5\u4e0b\u964d\u8d8b\u52bf\u66f4\u4e3a\u660e\u663e<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u672c\u7814\u7a76\u7684\u7597\u6548\u7ed3\u679c\u672a\u80fd\u663e\u793aAdMSCs\u6cbb\u7597\u7684\u76ca\u5904\uff0c\u53cd\u800c\u63d0\u793a\u6cbb\u7597\u7ec4\u8ba4\u77e5\u4e0b\u964d\u66f4\u591a\u3002\u5728\u6cbb\u7597\u540e<strong>30\u5468<\/strong>\u7684\u8bc4\u4f30\u4e2d\uff1a<\/p>\n<ul class=\"wp-block-list\">\n<li><strong>ADAS-Cog\u8bc4\u5206<\/strong>\uff08\u5206\u503c\u589e\u52a0\u8868\u793a\u6076\u5316\uff09\uff1a\u6cbb\u7597\u7ec4\u589e\u52a0\u4e86<strong>+5.9 \u00b1 6.8<\/strong>\uff0c\u800c\u5b89\u6170\u5242\u7ec4\u589e\u52a0\u4e86<strong>+3.0 \u00b1 5.4<\/strong>The<\/li>\n<li><strong>MMSE\u8bc4\u5206<\/strong>\uff08\u5206\u503c\u4e0b\u964d\u8868\u793a\u6076\u5316\uff09\uff1a\u6cbb\u7597\u7ec4\u4e0b\u964d\u4e86<strong>-3.4 \u00b1 2.8<\/strong>\uff0c\u800c\u5b89\u6170\u5242\u7ec4\u4e0b\u964d\u4e86<strong>-1.4 \u00b1 2.8<\/strong>The<br \/>\u8fd9\u4e9b\u6570\u636e\u8868\u660e\uff0c\u4e24\u7ec4\u7684\u8ba4\u77e5\u529f\u80fd\u5747\u968f\u75be\u75c5\u81ea\u7136\u8fdb\u7a0b\u6709\u6240\u4e0b\u964d\uff0c\u4f46<strong>\u6cbb\u7597\u7ec4\u7684\u4e0b\u964d\u5e45\u5ea6\u5728\u6570\u503c\u4e0a\u5927\u4e8e\u5b89\u6170\u5242\u7ec4<\/strong>\u3002\u7814\u7a76\u62a5\u544a<strong>\u672a\u63d0\u4f9b\u8fd9\u4e9b\u53d8\u5316\u7684p\u503c<\/strong>\uff0c\u56e0\u6b64\u65e0\u6cd5\u5224\u65ad\u7edf\u8ba1\u5b66\u663e\u8457\u6027\uff0c\u4f46\u660e\u786e\u7684\u6570\u503c\u8d8b\u52bf\u4e0d\u652f\u6301\u5176\u6709\u6548\u6027\u3002\u6b64\u5916\uff0c\u7814\u7a76<strong>\u672a\u62a5\u544a\u4efb\u4f55\u5728\u795e\u7ecf\u5f71\u50cf\u6216\u8111\u810a\u6db2\u751f\u7269\u6807\u5fd7\u7269\u65b9\u9762\u7684\u79ef\u6781\u53d8\u5316<\/strong>\uff0c\u7f3a\u4e4f\u5176\u53d1\u6325\u673a\u5236\u6d3b\u6027\u7684\u8bc1\u636e\u3002<\/li>\n<\/ul>\n<h3 id=\"ftoc-heading-26\" class=\"wp-block-heading ftwp-heading\"><span class=\"ez-toc-section\" id=\"%E8%AE%A8%E8%AE%BA%E4%B8%8E%E5%90%AF%E7%A4%BA%EF%BC%9A%E8%87%AA%E4%BD%93%E7%96%97%E6%B3%95%E7%9A%84%E7%8B%AC%E7%89%B9%E6%8C%91%E6%88%98%E4%B8%8E%E6%96%B9%E6%A1%88%E5%8F%8D%E6%80%9D\"><\/span>\u8ba8\u8bba\u4e0e\u542f\u793a\uff1a\u81ea\u4f53\u7597\u6cd5\u7684\u72ec\u7279\u6311\u6218\u4e0e\u65b9\u6848\u53cd\u601d<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u8be5\u7814\u7a76\u521d\u6b65\u8bc1\u5b9e\u4e86\u957f\u671f\u3001\u9ad8\u5242\u91cf\u9759\u8109\u8f93\u6ce8\u81ea\u4f53AdMSCs\u7684<strong>\u57fa\u672c\u5b89\u5168\u6027<\/strong>\uff0c\u4f46<strong>\u672a\u80fd\u63d0\u4f9b\u4efb\u4f55\u652f\u6301\u5176\u6709\u6548\u7684\u8bc1\u636e<\/strong>\u3002\u8fd9\u4e0e\u524d\u51e0\u4e2a\u5f02\u4f53\u6765\u6e90\uff08\u8110\u5e26\u8840\u3001\u9aa8\u9ad3\uff09MSCs\u7684\u7814\u7a76\u5f62\u6210\u4e86\u5bf9\u6bd4\u3002\u8ba8\u8bba\u8ba4\u4e3a\uff0c\u8fd9\u4e00\u9634\u6027\u7ed3\u679c\u53ef\u80fd\u6e90\u4e8e\u591a\u79cd\u56e0\u7d20\uff1a<strong>\u7814\u7a76\u6837\u672c\u91cf\u8f83\u5c0f<\/strong>\u53ef\u80fd\u5f71\u54cd\u4e86\u7ed3\u679c\u7684\u7a33\u5b9a\u6027\uff1b\u6240\u91c7\u7528\u7684<strong>\u9ad8\u9891\u7387\u3001\u9ad8\u5242\u91cf\u7684\u81ea\u4f53\u7ec6\u80de\u8f93\u6ce8\u65b9\u6848\u672c\u8eab\u53ef\u80fd\u5e76\u975e\u6700\u4f18<\/strong>\uff1b\u6b64\u5916\uff0c<strong>\u8102\u80aa\u6765\u6e90MSCs\u7684\u7279\u6027<\/strong>\uff08\u4e0e\u8110\u5e26\u8840\u6216\u9aa8\u9ad3\u6765\u6e90\u76f8\u6bd4\uff09\u662f\u5426\u9002\u5408\u6cbb\u7597AD\uff0c\u4e5f\u503c\u5f97\u8fdb\u4e00\u6b65\u63a2\u8ba8\u3002\u8fd9\u4e00\u6848\u4f8b\u63d0\u793a\uff0c\u5e76\u975e\u6240\u6709\u7684MSCs\u6cbb\u7597\u65b9\u6848\u90fd\u80fd\u4ea7\u751f\u79ef\u6781\u4fe1\u53f7\uff0c<strong>\u7ec6\u80de\u6765\u6e90\u3001\u7ed9\u836f\u65b9\u6848\u7b49\u56e0\u7d20\u5bf9\u7597\u6548\u6709\u51b3\u5b9a\u6027\u5f71\u54cd<\/strong>\u3002\u672a\u6765\u7684\u7814\u7a76\u9700\u8981\u66f4\u7cbe\u7ec6\u5730\u4f18\u5316\u8fd9\u4e9b\u53d8\u91cf\u3002<\/p>\n<h3 id=\"ftoc-heading-27\" class=\"wp-block-heading ftwp-heading\"><span class=\"ez-toc-section\" id=\"%E6%80%BB%E7%BB%93\"><\/span>\u603b\u7ed3<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u4e3a\u4e86\u8ba9\u4e0d\u540c\u7814\u7a76\u7684\u5173\u952e\u4fe1\u606f\u4e00\u76ee\u4e86\u7136\uff0c\u6211\u5148\u5c06\u5b83\u4eec\u6c47\u603b\u5728\u4e0b\u8868\u4e2d\uff1a<\/p>\n<figure class=\"wp-block-table is-style-stripes\" style=\"font-size:15px\">\n<table class=\"has-fixed-layout\">\n<thead>\n<tr>\n<th>\u7814\u7a76\u7b80\u79f0<\/th>\n<th>\u7ec6\u80de\u6765\u6e90\u4e0e\u7c7b\u578b<\/th>\n<th>\u6838\u5fc3\u8bbe\u8ba1<\/th>\n<th>\u7ed9\u836f\u9014\u5f84\u4e0e\u65b9\u6848<\/th>\n<th>\u4e3b\u8981\u5b89\u5168\u7ed3\u8bba<\/th>\n<th>\u4e3b\u8981\u7597\u6548\u4fe1\u53f7<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><strong>Kim\u7b49\u4eba (2018)<\/strong><\/td>\n<td>\u5f02\u4f53\u8110\u5e26\u8840MSCs<\/td>\n<td>\u5f00\u653e\u6807\u7b7e\u3001I\u671f\u3001\u5242\u91cf\u9012\u589e<\/td>\n<td><strong>\u7acb\u4f53\u5b9a\u5411\u8111\u5185\u6ce8\u5c04<\/strong>\uff08\u5355\u6b21\uff0c\u81f3\u6d77\u9a6c\/\u6954\u524d\u53f6\uff09<\/td>\n<td>\u5b89\u5168\uff0c\u65e0DLT\uff0c\u4e3b\u8981\u4e3a\u624b\u672f\u76f8\u5173\u4e00\u8fc7\u6027\u53cd\u5e94<\/td>\n<td><strong>\u9634\u6027<\/strong>\uff1a\u8ba4\u77e5\u3001\u5f71\u50cf\u3001\u751f\u7269\u6807\u5fd7\u7269\u5747\u65e0\u663e\u8457\u6539\u5584<\/td>\n<\/tr>\n<tr>\n<td><strong>\u91cd\u590d\u8111\u5ba4\u5185\u6ce8\u5c04 (2021)<\/strong><\/td>\n<td>\u5f02\u4f53\u8110\u5e26\u8840MSCs<\/td>\n<td>\u5f00\u653e\u6807\u7b7e\u3001I\u671f<\/td>\n<td><strong>\u8111\u5ba4\u5185\u6ce8\u5c04<\/strong>\uff08\u7ecfOmmaya\u50a8\u6db2\u56ca\uff0c<strong>\u91cd\u590d3\u6b21<\/strong>\uff09<\/td>\n<td>\u53ef\u884c\uff0c\u4f46\u5f15\u53d1\u53ef\u63a7\u7684<strong>\u6025\u6027\u708e\u75c7\u53cd\u5e94<\/strong>\uff08\u5982\u53d1\u70ed\uff09<\/td>\n<td><strong>\u6df7\u5408<\/strong>\uff1a\u68c0\u6d4b\u5230\u77ed\u671f\u751f\u7269\u6d3b\u6027\uff0c\u4f46<strong>\u65e0\u6301\u7eed\u8ba4\u77e5\u83b7\u76ca<\/strong><\/td>\n<\/tr>\n<tr>\n<td><strong>Lomecel-B I\u671f (2021)<\/strong><\/td>\n<td>\u5f02\u4f53\u9aa8\u9ad3MSCs<\/td>\n<td><strong>\u968f\u673a\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167<\/strong>\u3001I\u671f<\/td>\n<td><strong>intravenous infusion<\/strong>\uff08\u5355\u6b21\uff09<\/td>\n<td>\u5b89\u5168\u4e14\u8010\u53d7\u6027\u826f\u597d\uff0c<strong>\u65e0ARIA<\/strong><\/td>\n<td><strong>\u79ef\u6781<\/strong>::<strong>\u4f4e\u5242\u91cf\u7ec4<\/strong>\u5728\u8ba4\u77e5\u3001\u751f\u6d3b\u8d28\u91cf\u3001\u6d77\u9a6c\u4f53\u79ef\u6709\u79ef\u6781\u4fe1\u53f7<\/td>\n<\/tr>\n<tr>\n<td><strong>CLEAR-MIND IIa\u671f<\/strong><\/td>\n<td>\u5f02\u4f53\u9aa8\u9ad3MSCs<\/td>\n<td><strong>\u968f\u673a\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167<\/strong>\u3001IIa\u671f<\/td>\n<td><strong>intravenous infusion<\/strong>\uff08<strong>\u591a\u5242\u91cf\u7ec4<\/strong>(math.) genus<strong>\u91cd\u590d4\u6b21<\/strong>\uff09<\/td>\n<td>\u5b89\u5168\uff0c<strong>\u65e0ARIA<\/strong>\uff0cSAE\u4e0e\u836f\u7269\u65e0\u5173<\/td>\n<td><strong>\u79ef\u6781<\/strong>\uff1a\u7279\u5b9a\u5242\u91cf\u7ec4\u6539\u5584\u8ba4\u77e5\/\u529f\u80fd\uff0c<strong>\u663e\u8457\u51cf\u7f13\u8111\u840e\u7f29<\/strong>\uff08\u5168\u8111\/\u6d77\u9a6c\uff09<\/td>\n<\/tr>\n<tr>\n<td><strong>\u81ea\u4f53\u8102\u80aaMSCs\u7814\u7a76<\/strong><\/td>\n<td><strong>\u81ea\u4f53\u8102\u80aaMSCs<\/strong><\/td>\n<td>\u968f\u673a\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u3001I\/II\u671f<\/td>\n<td><strong>intravenous infusion<\/strong>\uff08<strong>\u9ad8\u98919\u6b21<\/strong>\uff09<\/td>\n<td>\u603b\u4f53\u53ef\u63a5\u53d7\uff0c\u62a5\u544a\u65e0\u5173SAE<\/td>\n<td><strong>\u9634\u6027<\/strong>\uff1a\u8ba4\u77e5\u8bc4\u5206<strong>\u672a\u663e\u793a\u83b7\u76ca\u8d8b\u52bf<\/strong><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/figure>\n<h3 id=\"ftoc-heading-28\" class=\"wp-block-heading ftwp-heading\"><span class=\"ez-toc-section\" id=\"%E5%8F%91%E5%B1%95%E8%84%89%E7%BB%9C%E4%B8%8E%E6%A0%B8%E5%BF%83%E5%8F%91%E7%8E%B0\"><\/span>\u53d1\u5c55\u8109\u7edc\u4e0e\u6838\u5fc3\u53d1\u73b0<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u8fd9\u4e94\u9879\u7814\u7a76\u6e05\u6670\u5730\u52fe\u52d2\u51fa\u8be5\u9886\u57df\u4ece\u201c\u63a2\u7d22\u80fd\u5426\u5b89\u5168\u7ed9\u836f\u201d\u5411\u201c\u9a8c\u8bc1\u662f\u5426\u6709\u6548\u201d\u6f14\u8fdb\u7684\u8fc7\u7a0b\uff1a<\/p>\n<p><strong>\u4ece\u5b89\u5168\u9a8c\u8bc1\u5230\u7597\u6548\u521d\u73b0<\/strong><\/p>\n<p>\u65e9\u671f\u7814\u7a76\uff08\u5982Kim\u7b49\u4eba\uff09\u6838\u5fc3\u8d21\u732e\u662f<strong>\u786e\u7acb\u4e86\u4e0d\u540c\u4fb5\u5165\u6027\u7ed9\u836f\u9014\u5f84\uff08\u8111\u5185\u3001\u8111\u5ba4\u5185\uff09\u7684\u64cd\u4f5c\u5b89\u5168\u6027<\/strong>\u3002\u968f\u540e\u7684\u7814\u7a76\uff0c\u5c24\u5176\u662f\u4e24\u9879\u5173\u4e8e<strong>Lomecel-B\uff08\u5f02\u4f53\u9aa8\u9ad3MSCs\uff09<\/strong>\u00a0\u7684\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\uff0c\u5728\u4e25\u8c28\u8bbe\u8ba1\u4e0b\uff0c\u4e0d\u4ec5\u53cd\u590d\u9a8c\u8bc1\u4e86\u9759\u8109\u8f93\u6ce8\u7684\u4f18\u5f02\u5b89\u5168\u6027\uff08\u7279\u522b\u662f<strong>\u65e0ARIA\u98ce\u9669<\/strong>\u8fd9\u4e00\u7a81\u51fa\u4f18\u52bf\uff09\uff0c\u66f4\u9996\u6b21\u63d0\u4f9b\u4e86<strong>\u53ef\u80fd\u5177\u6709\u75be\u75c5\u4fee\u9970\u4f5c\u7528<\/strong>\u7684\u79ef\u6781\u4fe1\u53f7\u2014\u2014\u5305\u62ec\u5ef6\u7f13\u8ba4\u77e5\u4e0b\u964d\u3001\u6539\u5584\u751f\u6d3b\u8d28\u91cf\uff0c\u4ee5\u53ca\u6700\u5177\u8bf4\u670d\u529b\u7684<strong>\u51cf\u7f13\u8111\u7ed3\u6784\uff08\u5168\u8111\u53ca\u6d77\u9a6c\uff09\u840e\u7f29<\/strong>\u7684\u5f71\u50cf\u5b66\u8bc1\u636e\u3002<\/p>\n<p><strong>\u5173\u952e\u53d8\u91cf\u51b3\u5b9a\u6210\u8d25\uff1a\u6765\u6e90\u3001\u9014\u5f84\u4e0e\u65b9\u6848<\/strong><\/p>\n<ul class=\"wp-block-list\">\n<li><strong>Cell Source<\/strong>\uff1a\u76ee\u524d\u6700\u6709\u5e0c\u671b\u7684\u4fe1\u53f7\u6765\u81ea<strong>\u5f02\u4f53\u9aa8\u9ad3\uff08Lomecel-B\uff09\u548c\u8110\u5e26\u8840\u6765\u6e90<\/strong>\u7684MSCs\u3002\u800c<strong>\u81ea\u4f53\u8102\u80aa\u6765\u6e90MSCs<\/strong>\u7684\u9ad8\u9891\u9759\u8109\u8f93\u6ce8\u65b9\u6848\u5e76\u672a\u663e\u793a\u76ca\u5904\uff0c\u63d0\u793a\u6765\u6e90\u548c\u65b9\u6848\u53ef\u80fd\u81f3\u5173\u91cd\u8981\u3002<\/li>\n<li><strong>\u7ed9\u836f\u9014\u5f84<\/strong>::<strong>intravenous infusion<\/strong>\u56e0\u65e0\u521b\u3001\u5b89\u5168\u4e14\u663e\u793a\u51fa\u6f5c\u529b\uff0c\u5df2\u6210\u4e3a\u4e3b\u6d41\u65b9\u5411\u3002\u66f4\u5177\u4fb5\u5165\u6027\u7684<strong>\u76f4\u63a5\u8111\u5185\/\u5ba4\u5185\u6ce8\u5c04<\/strong>\u867d\u80fd\u7cbe\u51c6\u9012\u9001\uff0c\u4f46\u64cd\u4f5c\u590d\u6742\u4e14\u53ef\u80fd\u5f15\u53d1\u66f4\u5f3a\u708e\u75c7\u53cd\u5e94\uff0c\u5176\u4f18\u52bf\u4ecd\u9700\u8fdb\u4e00\u6b65\u9a8c\u8bc1\u3002<\/li>\n<li><strong>treatment plan<\/strong>::<strong>\u91cd\u590d\u7ed9\u836f<\/strong>\uff08\u5982CLEAR-MIND\u8bd5\u9a8c\uff09\u76f8\u6bd4\u5355\u6b21\u7ed9\u836f\uff0c\u5728\u4ea7\u751f\u751f\u7269\u6548\u5e94\u548c\u4fdd\u62a4\u8111\u7ed3\u6784\u65b9\u9762\u53ef\u80fd\u66f4\u5177\u4f18\u52bf\u3002\u540c\u65f6\uff0c<strong>\u5e76\u975e\u5242\u91cf\u8d8a\u9ad8\u8d8a\u597d<\/strong>\uff0c\u591a\u9879\u7814\u7a76\u63d0\u793a\u5b58\u5728\u201c\u6700\u4f73\u5242\u91cf\u7a97\u53e3\u201d\uff0c\u4f4e\u5242\u91cf\u6709\u65f6\u6548\u679c\u66f4\u4f18\u3002<\/li>\n<\/ul>\n<p><strong>\u672a\u6765\u6311\u6218\u4e0e\u65b9\u5411<\/strong>\uff1a\u5c3d\u7ba1\u524d\u666f\u53ef\u671f\uff0c\u4f46\u6240\u6709\u7814\u7a76\u90fd\u6307\u51fa\uff0c\u5f53\u524d\u8bc1\u636e\u4ecd\u5904\u4e8e\u65e9\u671f\u9636\u6bb5\u3002\u8981\u5c06\u8fd9\u4e9b\u79ef\u6781\u4fe1\u53f7\u8f6c\u5316\u4e3a\u786e\u51ff\u7597\u6548\uff0c\u5fc5\u987b\u5f00\u5c55<strong>\u5927\u89c4\u6a21\u3001\u957f\u671f\u7684\u4e09\u671f\u4e34\u5e8a\u8bd5\u9a8c<\/strong>\u3002\u672a\u6765\u7814\u7a76\u7684\u6838\u5fc3\u5c06\u805a\u7126\u4e8e\uff1a<strong>\u786e\u5b9a\u6700\u4f18\u5316\u7684\u4eba\u7fa4\uff08\u5982\u57fa\u4e8e\u751f\u7269\u6807\u5fd7\u7269\u5206\u578b\uff09\u3001\u7ec6\u80de\u4ea7\u54c1\u3001\u7ed9\u836f\u65b9\u6848\uff08\u5242\u91cf\u3001\u9891\u7387\u3001\u5468\u671f\uff09<\/strong>\uff0c\u5e76\u6df1\u5165\u63a2\u7d22\u5176<strong>mechanism of action<\/strong>\uff08\u6297\u708e\u3001\u4fc3\u8fdb\u8840\u7ba1\u4fee\u590d\u3001\u795e\u7ecf\u4fdd\u62a4\u7b49\uff09\u3002<\/p>\n<ol start=\"1\" class=\"wp-block-list\"><\/ol>\n<p>\u603b\u800c\u8a00\u4e4b\uff0c\u8fd9\u4e94\u4e2a\u6848\u4f8b\u5171\u540c\u8868\u660e\uff0cMSCs\u7597\u6cd5\uff0c\u7279\u522b\u662f\u5f02\u4f53\u6765\u6e90\u3001\u7ecf\u9759\u8109\u91cd\u590d\u8f93\u6ce8\u7684\u65b9\u6848\uff0c\u5df2\u6210\u4e3aAD\u6cbb\u7597\u4e2d\u4e00\u4e2a<strong>\u5b89\u5168\u6027\u660e\u786e\u4e14\u6781\u5177\u6f5c\u529b\u7684\u65b0\u65b9\u5411<\/strong>\u3002\u5176\u771f\u6b63\u7684\u7597\u6548\u4ef7\u503c\uff0c\u6b63\u5f85\u672a\u6765\u5927\u89c4\u6a21\u786e\u8bc1\u6027\u7814\u7a76\u63ed\u6653\u3002<\/p>\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">","protected":false},"excerpt":{"rendered":"<p>[db:\u63cf\u8ff0]<\/p>","protected":false},"author":2,"featured_media":21317,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"image","meta":{"footnotes":""},"categories":[76],"tags":[269],"_links":{"self":[{"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/posts\/21323"}],"collection":[{"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/comments?post=21323"}],"version-history":[{"count":0,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/posts\/21323\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/media\/21317"}],"wp:attachment":[{"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/media?parent=21323"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/categories?post=21323"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/tags?post=21323"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}