{"id":21350,"date":"2026-01-27T01:12:15","date_gmt":"2026-01-26T09:12:15","guid":{"rendered":"https:\/\/www.hjtdsm.cn\/stem-cells\/stem-cell-therapy\/21350.html"},"modified":"2026-01-27T01:12:15","modified_gmt":"2026-01-26T09:12:15","slug":"%e5%b9%b2%e7%bb%86%e8%83%9e%e6%b2%bb%e7%96%97%e5%b8%95%e9%87%91%e6%a3%ae%e7%97%85%ef%bc%9a%e6%8f%90%e9%ab%98%e4%ba%ba%e5%b9%b2%e7%bb%86%e8%83%9e%e6%ba%90%e5%a4%9a%e5%b7%b4%e8%83%ba%e8%83%bd%e7%a5%9e","status":"publish","type":"post","link":"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/21350.html","title":{"rendered":"\u5e72\u7ec6\u80de\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\uff1a\u63d0\u9ad8\u4eba\u5e72\u7ec6\u80de\u6e90\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u5b58\u6d3b\u7387\u7684\u4e24\u79cd\u65b9\u6cd5"},"content":{"rendered":"<p><strong>\u6458\u8981<\/strong>\uff1a\u5e15\u91d1\u68ee\u75c5\uff08PD\uff09\u7684\u5e72\u7ec6\u80de\u66ff\u4ee3\u7597\u6cd5\u867d\u524d\u666f\u5e7f\u9614\uff0c\u4f46\u79fb\u690d\u540e\u591a\u5df4\u80fa\u80fd\uff08DA\uff09\u795e\u7ecf\u5143\u6781\u4f4e\u7684\u5b58\u6d3b\u7387\uff08&gt;90%\u7684\u4e22\u5931\uff09\u4e25\u91cd\u963b\u788d\u5176\u7597\u6548\u3002\u672c\u6587\u805a\u7126\u4e8e\u8fd9\u4e00\u6838\u5fc3\u6311\u6218\uff0c\u7efc\u8ff0\u4e86\u8fd1\u671f\u7a81\u7834\u6027\u7814\u7a76\u63ed\u793a\u7684\u7ec6\u80de\u6b7b\u4ea1\u5173\u952e\u673a\u5236\u2014\u2014<strong>TNF\u03b1-NF\u03baB-p53\u4fe1\u53f7\u8f74<\/strong>\uff0c\u5e76\u63d0\u51fa\u4e86\u4e24\u9879\u6838\u5fc3\u89e3\u51b3\u65b9\u6848\uff1a<\/p>\n<ul class=\"wp-block-list\">\n<li><strong>1\uff09\u77ed\u671f\u4f7f\u7528\u4e34\u5e8a\u6279\u51c6\u7684TNF\u03b1\u6291\u5236\u5242\uff08\u5982\u963f\u8fbe\u6728\u5355\u6297\uff09<\/strong>\u00a0\u4ee5\u963b\u65ad\u8be5\u6b7b\u4ea1\u901a\u8def\uff1b<\/li>\n<li><strong>2\uff09\u5229\u7528\u7279\u5b9a\u7ec6\u80de\u8868\u9762\u6807\u5fd7\u7269\uff08CD49e^low\/CD184^high\uff09\u8fdb\u884c\u65e0\u57fa\u56e0\u5de5\u7a0b\u5316\u7684DA\u795e\u7ecf\u5143\u7eaf\u5316<\/strong>\uff0c\u4ee5\u6d88\u9664\u975e\u76ee\u6807\u7ec6\u80de\u5e26\u6765\u7684\u98ce\u9669\u3002<\/li>\n<\/ul>\n<p>\u8fd9\u4e24\u5927\u7b56\u7565\u76f8\u8f85\u76f8\u6210\uff0c\u4e3a\u63d0\u5347\u79fb\u690d\u7ec6\u80de\u5b58\u6d3b\u7387\u3001\u63a8\u52a8PD\u7ec6\u80de\u7597\u6cd5\u8d70\u5411\u5b89\u5168\u6709\u6548\u7684\u4e34\u5e8a\u8f6c\u5316\u63d0\u4f9b\u4e86\u660e\u786e\u8def\u5f84\u3002<\/p>\n<p><button type=\"button\" id=\"ftwp-trigger\" class=\"ftwp-shape-round ftwp-border-medium\" title=\"click To Maximize The Table Of Contents\"><span class=\"ftwp-trigger-icon ftwp-icon-number\"><\/span><\/button><\/p>\n<nav id=\"ftwp-contents\" class=\"ftwp-shape-square ftwp-border-medium\">\n<header id=\"ftwp-header\"><span id=\"ftwp-header-control\" class=\"ftwp-icon-number\"><\/span><button type=\"button\" id=\"ftwp-header-minimize\" class=\"ftwp-icon-expand\" aria-labelledby=\"ftwp-header-title\" aria-label=\"Expand or collapse\"><\/button><\/p>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_79_2 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewbox=\"0 0 24 24\" version=\"1.2\" baseprofile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1' ><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/21350.html\/#Contents\" >Contents<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/21350.html\/#%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E5%B8%95%E9%87%91%E6%A3%AE%E7%97%85%EF%BC%9A%E6%8F%90%E9%AB%98%E4%BA%BA%E5%B9%B2%E7%BB%86%E8%83%9E%E6%BA%90%E5%A4%9A%E5%B7%B4%E8%83%BA%E8%83%BD%E7%A5%9E%E7%BB%8F%E5%85%83%E5%AD%98%E6%B4%BB%E7%8E%87%E7%9A%84%E4%B8%A4%E7%A7%8D%E6%96%B9%E6%B3%95\" >\u5e72\u7ec6\u80de\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\uff1a\u63d0\u9ad8\u4eba\u5e72\u7ec6\u80de\u6e90\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u5b58\u6d3b\u7387\u7684\u4e24\u79cd\u65b9\u6cd5<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/21350.html\/#%E6%A0%B8%E5%BF%83%E6%8C%91%E6%88%98%E5%89%96%E6%9E%90%EF%BC%9A%E7%A7%BB%E6%A4%8D%E7%A5%9E%E7%BB%8F%E5%85%83%E4%B8%BA%E4%BD%95%E5%A4%A7%E9%87%8F%E6%AD%BB%E4%BA%A1%EF%BC%9F\" >\u6838\u5fc3\u6311\u6218\u5256\u6790\uff1a\u79fb\u690d\u795e\u7ecf\u5143\u4e3a\u4f55\u5927\u91cf\u6b7b\u4ea1\uff1f<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/21350.html\/#%E8%A7%A3%E5%86%B3%E6%96%B9%E6%A1%88%E4%B8%80%EF%BC%9A%E9%9D%B6%E5%90%91%E6%AD%BB%E4%BA%A1%E9%80%9A%E8%B7%AF%E2%80%94%E2%80%94%E7%9F%AD%E6%9A%82%E6%8A%91%E5%88%B6TNF%CE%B1%E4%BF%A1%E5%8F%B7\" >\u89e3\u51b3\u65b9\u6848\u4e00\uff1a\u9776\u5411\u6b7b\u4ea1\u901a\u8def\u2014\u2014\u77ed\u6682\u6291\u5236TNF\u03b1\u4fe1\u53f7<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/21350.html\/#%E8%A7%A3%E5%86%B3%E6%96%B9%E6%A1%88%E4%BA%8C%EF%BC%9A%E4%BC%98%E5%8C%96%E7%A7%BB%E6%A4%8D%E7%BB%86%E8%83%9E%E4%BA%A7%E5%93%81%E2%80%94%E2%80%94%E6%97%A0%E5%9F%BA%E5%9B%A0%E6%A0%87%E8%AE%B0%E7%9A%84DA%E7%A5%9E%E7%BB%8F%E5%85%83%E7%BA%AF%E5%8C%96\" >\u89e3\u51b3\u65b9\u6848\u4e8c\uff1a\u4f18\u5316\u79fb\u690d\u7ec6\u80de\u4ea7\u54c1\u2014\u2014\u65e0\u57fa\u56e0\u6807\u8bb0\u7684DA\u795e\u7ecf\u5143\u7eaf\u5316<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/21350.html\/#%E4%B8%B4%E5%BA%8A%E8%BD%AC%E5%8C%96%E5%89%8D%E6%99%AF%E4%B8%8E%E7%BB%BC%E5%90%88%E5%BA%94%E7%94%A8\" >\u4e34\u5e8a\u8f6c\u5316\u524d\u666f\u4e0e\u7efc\u5408\u5e94\u7528<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/21350.html\/#%E6%9C%AA%E6%9D%A5%E5%B1%95%E6%9C%9B%E4%B8%8E%E5%BE%85%E8%A7%A3%E9%97%AE%E9%A2%98\" >\u672a\u6765\u5c55\u671b\u4e0e\u5f85\u89e3\u95ee\u9898<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/21350.html\/#%E7%BB%93%E8%AE%BA\" >reach a verdict<\/a><\/li><\/ul><\/nav><\/div>\n<h3 id=\"ftwp-header-title\"><span class=\"ez-toc-section\" id=\"Contents\"><\/span>Contents<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<\/header>\n<ol id=\"ftwp-list\" class=\"ftwp-liststyle-decimal ftwp-effect-bounce-to-right ftwp-list-nest ftwp-strong-first ftwp-colexp ftwp-colexp-icon\">\n<li class=\"ftwp-item ftwp-has-sub ftwp-expand\"><button type=\"button\" aria-label=\"Expand or collapse\" class=\"ftwp-icon-expand\"><\/button><span class=\"ftwp-text\">\u5e72\u7ec6\u80de\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\uff1a\u63d0\u9ad8\u4eba\u5e72\u7ec6\u80de\u6e90\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u5b58\u6d3b\u7387\u7684\u4e24\u79cd\u65b9\u6cd5<\/span>\n<ol class=\"ftwp-sub\">\n<li class=\"ftwp-item\"><span class=\"ftwp-text\">\u6838\u5fc3\u6311\u6218\u5256\u6790\uff1a\u79fb\u690d\u795e\u7ecf\u5143\u4e3a\u4f55\u5927\u91cf\u6b7b\u4ea1\uff1f<\/span><\/li>\n<li class=\"ftwp-item\"><span class=\"ftwp-text\">\u89e3\u51b3\u65b9\u6848\u4e00\uff1a\u9776\u5411\u6b7b\u4ea1\u901a\u8def\u2014\u2014\u77ed\u6682\u6291\u5236TNF\u03b1\u4fe1\u53f7<\/span><\/li>\n<li class=\"ftwp-item\"><span class=\"ftwp-text\">\u89e3\u51b3\u65b9\u6848\u4e8c\uff1a\u4f18\u5316\u79fb\u690d\u7ec6\u80de\u4ea7\u54c1\u2014\u2014\u65e0\u57fa\u56e0\u6807\u8bb0\u7684DA\u795e\u7ecf\u5143\u7eaf\u5316<\/span><\/li>\n<\/ol>\n<\/li>\n<li class=\"ftwp-item\"><span class=\"ftwp-text\">\u4e34\u5e8a\u8f6c\u5316\u524d\u666f\u4e0e\u7efc\u5408\u5e94\u7528<\/span><\/li>\n<li class=\"ftwp-item\"><span class=\"ftwp-text\">\u672a\u6765\u5c55\u671b\u4e0e\u5f85\u89e3\u95ee\u9898<\/span><\/li>\n<li class=\"ftwp-item\"><span class=\"ftwp-text\">reach a verdict<\/span><\/li>\n<\/ol>\n<\/nav>\n<h2 id=\"jcl-p-7\" class=\"wp-block-heading ftwp-heading\"><span class=\"ez-toc-section\" id=\"%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E5%B8%95%E9%87%91%E6%A3%AE%E7%97%85%EF%BC%9A%E6%8F%90%E9%AB%98%E4%BA%BA%E5%B9%B2%E7%BB%86%E8%83%9E%E6%BA%90%E5%A4%9A%E5%B7%B4%E8%83%BA%E8%83%BD%E7%A5%9E%E7%BB%8F%E5%85%83%E5%AD%98%E6%B4%BB%E7%8E%87%E7%9A%84%E4%B8%A4%E7%A7%8D%E6%96%B9%E6%B3%95\"><\/span><strong><span class=\"xintheme_tag_link\">Stem cell therapy for Parkinson's disease<\/span>\uff1a\u63d0\u9ad8\u4eba\u5e72\u7ec6\u80de\u6e90\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u5b58\u6d3b\u7387\u7684\u4e24\u79cd\u65b9\u6cd5<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p id=\"JCL-P-7\">\u5e15\u91d1\u68ee\u75c5\uff08PD\uff09\u4f5c\u4e3a\u7b2c\u4e8c\u5e38\u89c1\u7684\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\uff0c\u5176\u6838\u5fc3\u75c5\u7406\u7279\u5f81\u662f\u4e2d\u8111\u9ed1\u8d28\u591a\u5df4\u80fa\uff08DA\uff09\u80fd\u795e\u7ecf\u5143\u7684\u8fdb\u884c\u6027\u9000\u5316\uff0c\u5bfc\u81f4\u8fd0\u52a8\u529f\u80fd\u4e25\u91cd\u53d7\u635f\u3002\u73b0\u6709\u836f\u7269\u5982\u5de6\u65cb\u591a\u5df4\u4ec5\u80fd\u5bf9\u75c7\u6cbb\u7597\uff0c\u65e0\u6cd5\u9006\u8f6c\u75be\u75c5\u8fdb\u7a0b\u3002\u57fa\u4e8e\u4eba\u591a\u80fd\u5e72\u7ec6\u80de\uff08hPSC\uff0c\u5305\u62ec\u80da\u80ce\u5e72\u7ec6\u80de\u548c\u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de\uff09\u7684\u7ec6\u80de\u66ff\u4ee3\u7597\u6cd5\uff0c\u65e8\u5728\u901a\u8fc7\u79fb\u690d\u65b0\u7684DA\u795e\u7ecf\u5143\u4ece\u6839\u672c\u4e0a\u6062\u590d\u795e\u7ecf\u73af\u8def\u529f\u80fd\uff0c\u88ab\u89c6\u4e3a\u6781\u5177\u524d\u666f\u7684\u6cbb\u6108\u6027\u7b56\u7565\uff0c\u5e76\u5df2\u8fdb\u5165\u4e34\u5e8a\u8bd5\u9a8c\u9636\u6bb5\u3002<\/p>\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" loading=\"lazy\" width=\"612\" height=\"459\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2026\/01\/20260126171214-69772fee75726.jpg\" alt=\"\u5e72\u7ec6\u80de\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\uff1a\u63d0\u9ad8\u4eba\u5e72\u7ec6\u80de\u6e90\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u5b58\u6d3b\u7387\u7684\u4e24\u79cd\u65b9\u6cd5\" class=\"wp-image-58776\" title=\"\u5e72\u7ec6\u80de\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\uff1a\u63d0\u9ad8\u4eba\u5e72\u7ec6\u80de\u6e90\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u5b58\u6d3b\u7387\u7684\u4e24\u79cd\u65b9\u6cd5\"><figcaption class=\"wp-element-caption\"><span class=\"xintheme_tag_link\">stem cell therapy<\/span>\u5e15\u91d1\u68ee\u75c5\uff1a\u63d0\u9ad8\u4eba\u5e72\u7ec6\u80de\u6e90\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u5b58\u6d3b\u7387\u7684\u4e24\u79cd\u65b9\u6cd5<\/figcaption><\/figure>\n<p>\u7136\u800c\uff0c\u8be5\u7597\u6cd5\u7684\u8f6c\u5316\u9762\u4e34\u4e25\u5cfb\u6311\u6218\u3002\u5176\u4e2d\u6700\u7a81\u51fa\u7684\u662f<strong>\u79fb\u690d\u540eDA\u795e\u7ecf\u5143\u7684\u5b58\u6d3b\u7387\u6781\u4f4e<\/strong>\uff0c\u8d85\u8fc790%\u7684\u7ec6\u80de\u5728\u79fb\u690d\u540e\u6b7b\u4ea1\uff0c\u5bfc\u81f4\u7597\u6548\u4e0d\u7a33\u5b9a\u4e14\u4e0d\u53ef\u9884\u6d4b\u3002\u540c\u65f6\uff0c\u79fb\u690d\u4ea7\u7269\u4e2d\u6df7\u6742\u7684\u975eDA\u7ec6\u80de\uff08\u5982\u8840\u6e05\u7d20\u80fd\u795e\u7ecf\u5143\uff09\u53ef\u80fd\u5f15\u53d1\u79fb\u690d\u7269\u8bf1\u5bfc\u7684\u8fd0\u52a8\u969c\u788d\u7b49\u526f\u4f5c\u7528\u3002\u56e0\u6b64\uff0c<strong>\u5982\u4f55\u63d0\u9ad8\u79fb\u690dDA\u795e\u7ecf\u5143\u7684\u5b58\u6d3b\u7387\u5e76\u786e\u4fdd\u4ea7\u7269\u7eaf\u5ea6<\/strong>\uff0c\u6210\u4e3a\u9886\u57df\u5185\u4e9f\u5f85\u89e3\u51b3\u7684\u6838\u5fc3\u79d1\u5b66\u95ee\u9898\u3002<\/p>\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" loading=\"lazy\" width=\"840\" height=\"441\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2026\/01\/20260126171214-69772fee850f3.png\" alt=\"\" class=\"wp-image-58775\" title=\"\"><figcaption><\/figcaption><\/figure>\n<h3 id=\"ftoc-heading-2\" class=\"wp-block-heading ftwp-heading\"><span class=\"ez-toc-section\" id=\"%E6%A0%B8%E5%BF%83%E6%8C%91%E6%88%98%E5%89%96%E6%9E%90%EF%BC%9A%E7%A7%BB%E6%A4%8D%E7%A5%9E%E7%BB%8F%E5%85%83%E4%B8%BA%E4%BD%95%E5%A4%A7%E9%87%8F%E6%AD%BB%E4%BA%A1%EF%BC%9F\"><\/span><strong>\u6838\u5fc3\u6311\u6218\u5256\u6790\uff1a\u79fb\u690d\u795e\u7ecf\u5143\u4e3a\u4f55\u5927\u91cf\u6b7b\u4ea1\uff1f<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u8fd1\u671f\u7814\u7a76\u4e3a\u63ed\u793a\u7ec6\u80de\u6b7b\u4ea1\u673a\u5236\u5e26\u6765\u4e86\u7a81\u7834\u3002Kim\u7b49\u4eba\uff082024\uff09\u5229\u7528\u4f53\u5185CRISPR-Cas9\u7b5b\u9009\u6280\u672f\u53d1\u73b0\uff0c\u80bf\u7624\u6291\u5236\u86cb\u767d<strong>p53\u662f\u9650\u5236\u79fb\u690d\u540eDA\u795e\u7ecf\u5143\u5b58\u6d3b\u7684\u5173\u952e\u56e0\u5b50<\/strong>\uff08\u56fe1\uff09\u3002\u8fd9\u4e00\u53d1\u73b0\u4e0ePD\u75c5\u7406\u4e2dp53\u6c34\u5e73\u5347\u9ad8\u7684\u73b0\u8c61\u76f8\u543b\u5408\u3002\u8fdb\u4e00\u6b65\u7814\u7a76\u53d1\u73b0\uff0c\u5728\u79fb\u690d\u65e9\u671f\uff0c<strong>\u80bf\u7624\u574f\u6b7b\u56e0\u5b50-\u03b1\uff08TNF\u03b1\uff09<\/strong>\u00a0\u901a\u8fc7\u6fc0\u6d3b\u6838\u56e0\u5b50\u03baB\uff08NF\u03baB\uff09\u4fe1\u53f7\uff0c\u8fdb\u800c\u4e0a\u8c03\u5e76\u6fc0\u6d3bp53\uff0c\u6700\u7ec8\u542f\u52a8DA\u795e\u7ecf\u5143\u7684\u7a0b\u5e8f\u6027\u6b7b\u4ea1\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u8fd9\u79cdTNF\u03b1\u4e0d\u4ec5\u6765\u6e90\u4e8e\u5bbf\u4e3b\u514d\u75ab\u53cd\u5e94\uff0c<strong>\u79fb\u690d\u7684DA\u795e\u7ecf\u5143\u81ea\u8eab\u4e5f\u4f1a\u8868\u8fbeTNF\u03b1<\/strong>\uff0c\u5f62\u6210\u4e00\u79cd\u81ea\u6211\u9650\u5236\u7684\u201c\u7ec6\u80de\u81ea\u4e3b\u6027\u6b7b\u4ea1\u201d\u73af\u8def\u3002<\/p>\n<figure class=\"wp-block-image size-full is-resized\"><img decoding=\"async\" loading=\"lazy\" width=\"660\" height=\"342\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2026\/01\/20260126171214-69772feeb3615.jpeg\" alt=\"\u56fe1\uff1a\u672c\u6587\u63a2\u8ba8\u4e86\u63d0\u9ad8\u79fb\u690d\u540e\u7ecfNURR1\u9a71\u52a8\u7684GFP\u8868\u8fbe\u6216\u57fa\u4e8eCD49e\u548cCD184\u6807\u8bb0\u5206\u79bb\u7eaf\u5316\u7684\u6709\u4e1d\u5206\u88c2\u540e\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u4f53\u5185\u5b58\u6d3b\u7387\u7684\u7b56\u7565\u3002\" class=\"wp-image-58774\" style=\"width:840px;height:auto\" title=\"\"><figcaption class=\"wp-element-caption\">\u56fe1\uff1a\u672c\u6587\u63a2\u8ba8\u4e86\u63d0\u9ad8\u79fb\u690d\u540e\u7ecfNURR1\u9a71\u52a8\u7684GFP\u8868\u8fbe\u6216\u57fa\u4e8eCD49e\u548cCD184\u6807\u8bb0\u5206\u79bb\u7eaf\u5316\u7684\u6709\u4e1d\u5206\u88c2\u540e\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u4f53\u5185\u5b58\u6d3b\u7387\u7684\u7b56\u7565\u3002<\/figcaption><\/figure>\n<h3 id=\"ftoc-heading-3\" class=\"wp-block-heading ftwp-heading\"><span class=\"ez-toc-section\" id=\"%E8%A7%A3%E5%86%B3%E6%96%B9%E6%A1%88%E4%B8%80%EF%BC%9A%E9%9D%B6%E5%90%91%E6%AD%BB%E4%BA%A1%E9%80%9A%E8%B7%AF%E2%80%94%E2%80%94%E7%9F%AD%E6%9A%82%E6%8A%91%E5%88%B6TNF%CE%B1%E4%BF%A1%E5%8F%B7\"><\/span><strong>\u89e3\u51b3\u65b9\u6848\u4e00\uff1a\u9776\u5411\u6b7b\u4ea1\u901a\u8def\u2014\u2014\u77ed\u6682\u6291\u5236TNF\u03b1\u4fe1\u53f7<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u65e2\u7136TNF\u03b1-NF\u03baB-p53\u8f74\u662f\u5bfc\u81f4\u6b7b\u4ea1\u7684\u5173\u952e\u901a\u8def\uff0c\u6291\u5236\u8be5\u901a\u8def\u5c31\u6210\u4e3a\u63d0\u9ad8\u5b58\u6d3b\u7387\u7684\u76f4\u63a5\u7b56\u7565\u3002\u7814\u7a76\u8868\u660e\uff0c\u5728\u79fb\u690d\u540e\u5173\u952e\u7a97\u53e3\u671f\uff0c\u77ed\u671f\u4f7f\u7528\u4e34\u5e8a\u5df2\u5e7f\u6cdb\u5e94\u7528\u7684<strong>TNF\u03b1\u6291\u5236\u5242\uff08\u5982\u963f\u8fbe\u6728\u5355\u6297\uff09<\/strong>\uff0c\u80fd\u663e\u8457\u63d0\u9ad8\u4e34\u5e8a\u524d\u52a8\u7269\u6a21\u578b\u4e2d\u79fb\u690dDA\u795e\u7ecf\u5143\u7684\u5b58\u6d3b\u7387\uff0c\u5e76\u4f34\u968f\u8fd0\u52a8\u529f\u80fd\u7684\u6539\u5584\u3002<\/p>\n<p>\u6b64\u7b56\u7565\u7684\u4f18\u52bf\u5728\u4e8e\uff1a<\/p>\n<ul class=\"wp-block-list\">\n<li>1\uff09<strong>\u8f6c\u5316\u901f\u5ea6\u5feb<\/strong>\uff1a\u963f\u8fbe\u6728\u5355\u6297\u7b49\u836f\u7269\u5b89\u5168\u6027\u5df2\u77e5\uff0c\u201c\u8001\u836f\u65b0\u7528\u201d\u53ef\u5927\u5e45\u7f29\u77ed\u7814\u53d1\u5468\u671f\uff1b<\/li>\n<li>2\uff09<strong>\u6cbb\u7597\u7a97\u53e3\u660e\u786e<\/strong>\uff1a\u4ec5\u5728\u79fb\u690d\u524d\u540e\u77ed\u671f\u7ed9\u836f\uff0c\u5373\u53ef\u6709\u6548\u963b\u65ad\u65e9\u671f\u6b7b\u4ea1\u6f6e\uff0c\u907f\u514d\u957f\u671f\u514d\u75ab\u6291\u5236\u7684\u6f5c\u5728\u98ce\u9669\u3002<\/li>\n<\/ul>\n<h3 id=\"ftoc-heading-4\" class=\"wp-block-heading ftwp-heading\"><span class=\"ez-toc-section\" id=\"%E8%A7%A3%E5%86%B3%E6%96%B9%E6%A1%88%E4%BA%8C%EF%BC%9A%E4%BC%98%E5%8C%96%E7%A7%BB%E6%A4%8D%E7%BB%86%E8%83%9E%E4%BA%A7%E5%93%81%E2%80%94%E2%80%94%E6%97%A0%E5%9F%BA%E5%9B%A0%E6%A0%87%E8%AE%B0%E7%9A%84DA%E7%A5%9E%E7%BB%8F%E5%85%83%E7%BA%AF%E5%8C%96\"><\/span><strong>\u89e3\u51b3\u65b9\u6848\u4e8c\uff1a\u4f18\u5316\u79fb\u690d\u7ec6\u80de\u4ea7\u54c1\u2014\u2014\u65e0\u57fa\u56e0\u6807\u8bb0\u7684DA\u795e\u7ecf\u5143\u7eaf\u5316<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u63d0\u9ad8\u5b58\u6d3b\u7387\u4e0d\u4ec5\u9700\u8981\u201c\u6551\u6d3b\u201d\u7ec6\u80de\uff0c\u8fd8\u9700\u4ece\u6e90\u5934\u4f18\u5316\u79fb\u690d\u7ec6\u80de\u672c\u8eab\u3002\u4f20\u7edf\u4f9d\u8d56\u9057\u4f20\u62a5\u544a\u57fa\u56e0\uff08\u5982NURR1-GFP\uff09\u7684\u7eaf\u5316\u65b9\u6cd5\u56e0\u6d89\u53ca\u57fa\u56e0\u5de5\u7a0b\u800c\u4e0d\u9002\u4e8e\u4e34\u5e8a\u3002\u4e3a\u89e3\u51b3\u6b64\u95ee\u9898\uff0c\u7814\u7a76\u8005\u901a\u8fc7\u7b5b\u9009\u9274\u5b9a\u51fa\u4e00\u7ec4\u7ec6\u80de\u8868\u9762\u6807\u5fd7\u7269\u7ec4\u5408\uff1a<strong>CD49e (\u4f4e\u8868\u8fbe) \u548c CD184 (\u9ad8\u8868\u8fbe)<\/strong>\u3002\u5229\u7528\u6d41\u5f0f\u7ec6\u80de\u672f\u5206\u9009\u8be5\u6807\u5fd7\u7269\u9633\u6027\u7684\u7ec6\u80de\uff0c\u5373\u53ef\u5728\u4e0d\u8fdb\u884c\u57fa\u56e0\u6539\u9020\u7684\u524d\u63d0\u4e0b\uff0c\u9ad8\u6548\u5bcc\u96c6\u5230\u9ad8\u7eaf\u5ea6\u7684\u3001\u6709\u4e1d\u5206\u88c2\u540e\u7684DA\u795e\u7ecf\u5143\u3002<\/p>\n<p>\u8fd9\u4e00\u7eaf\u5316\u7b56\u7565\u7684\u610f\u4e49\u91cd\u5927\uff1a<\/p>\n<ul class=\"wp-block-list\">\n<li>1\uff09<strong>\u4e34\u5e8a\u517c\u5bb9\u6027\u597d<\/strong>\uff1a\u9002\u7528\u4e8e\u4efb\u4f55hPSC\/iPSC\u7cfb\uff0c\u4e3a\u81ea\u4f53\u6216\u5f02\u4f53\u6cbb\u7597\u63d0\u4f9b\u4e86\u901a\u7528\u65b9\u6848\uff1b<\/li>\n<li>2\uff09<strong>\u63d0\u5347\u5b89\u5168\u6027\u4e0e\u7597\u6548<\/strong>\uff1a\u53bb\u9664\u975e\u76ee\u6807\u7ec6\u80de\uff0c\u964d\u4f4e\u4e86\u8fd0\u52a8\u969c\u788d\u7b49\u526f\u4f5c\u7528\u98ce\u9669\uff0c\u5e76\u53ef\u80fd\u5bcc\u96c6\u5bf9PD\u6cbb\u7597\u81f3\u5173\u91cd\u8981\u7684\u3001\u6613\u53d7\u635f\u7684A9\u4e9a\u578bDA\u795e\u7ecf\u5143\uff1b<\/li>\n<li>3\uff09<strong>\u4fdd\u8bc1\u4ea7\u54c1\u4e00\u81f4\u6027<\/strong>\uff1a\u4e3a\u6807\u51c6\u5316\u7ec6\u80de\u5236\u5242\u751f\u4ea7\u5960\u5b9a\u4e86\u57fa\u7840\u3002<\/li>\n<\/ul>\n<h2 id=\"ftoc-heading-5\" class=\"wp-block-heading ftwp-heading\"><span class=\"ez-toc-section\" id=\"%E4%B8%B4%E5%BA%8A%E8%BD%AC%E5%8C%96%E5%89%8D%E6%99%AF%E4%B8%8E%E7%BB%BC%E5%90%88%E5%BA%94%E7%94%A8\"><\/span><strong>\u4e34\u5e8a\u8f6c\u5316\u524d\u666f\u4e0e\u7efc\u5408\u5e94\u7528<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>\u5c06\u4e0a\u8ff0\u4e24\u5927\u7b56\u7565\u2014\u2014<strong>\u56f4\u79fb\u690d\u671f\u77ed\u671fTNF\u03b1\u6291\u5236<\/strong>\u4e0e<strong>\u79fb\u690d\u524d\u57fa\u4e8e\u8868\u9762\u6807\u5fd7\u7269\u7684DA\u795e\u7ecf\u5143\u7eaf\u5316<\/strong>\u2014\u2014\u76f8\u7ed3\u5408\uff0c\u6784\u6210\u4e86\u4e00\u4e2a\u534f\u540c\u589e\u5f3a\u7684\u89e3\u51b3\u65b9\u6848\u3002\u524d\u8005\u4e3a\u79fb\u690d\u7ec6\u80de\u521b\u9020\u4e86\u521d\u59cb\u751f\u5b58\u7a97\u53e3\uff0c\u540e\u8005\u5219\u63d0\u4f9b\u4e86\u6700\u4f18\u5316\u7684\u201c\u79cd\u5b50\u201d\u7ec6\u80de\u3002<br \/>\u8fd9\u4e00\u7b56\u7565\u7684\u4ef7\u503c\u4e0d\u4ec5\u9650\u4e8ePD\u3002TNF\u03b1\u4ecb\u5bfc\u7684\u708e\u75c7\u6027\u6b7b\u4ea1\u662f\u8bb8\u591a\u7ec6\u80de\u79fb\u690d\u9762\u4e34\u7684\u5171\u6027\u969c\u788d\uff0c\u56e0\u6b64\u8be5\u65b9\u6848\u4e3a\u5176\u4ed6\u75be\u75c5\u7684\u7ec6\u80de\u6cbb\u7597\uff08\u5982\u89c6\u7f51\u819c\u7ec6\u80de\u6cbb\u7597\u9ec4\u6591\u53d8\u6027\u3001\u80f0\u5c9b\u7ec6\u80de\u6cbb\u7597\u7cd6\u5c3f\u75c5\uff09\u63d0\u4f9b\u4e86\u91cd\u8981\u53c2\u8003\u3002\u6b64\u5916\uff0c\u6d41\u884c\u75c5\u5b66\u6570\u636e\u63d0\u793a\uff0c\u957f\u671f\u4f7f\u7528TNF\u03b1\u6291\u5236\u5242\u7684\u60a3\u8005PD\u53d1\u75c5\u7387\u964d\u4f4e\uff0c\u6697\u793a\u8be5\u7b56\u7565\u53ef\u80fd\u5bf9\u539f\u751f\u795e\u7ecf\u5143\u4e5f\u6709\u4fdd\u62a4\u4f5c\u7528\uff0c\u6216\u6709\u5229\u4e8e\u79fb\u690d\u7269\u7684\u957f\u671f\u6574\u5408\u3002<\/p>\n<h2 id=\"ftoc-heading-6\" class=\"wp-block-heading ftwp-heading\"><span class=\"ez-toc-section\" id=\"%E6%9C%AA%E6%9D%A5%E5%B1%95%E6%9C%9B%E4%B8%8E%E5%BE%85%E8%A7%A3%E9%97%AE%E9%A2%98\"><\/span><strong>\u672a\u6765\u5c55\u671b\u4e0e\u5f85\u89e3\u95ee\u9898<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>\u5c3d\u7ba1\u524d\u666f\u5149\u660e\uff0c\u4ecd\u6709\u8bf8\u591a\u95ee\u9898\u6709\u5f85\u63a2\u7d22\uff1a<\/p>\n<p>\u9996\u5148\uff0cTNF\u03b1\u6291\u5236\u4ec5\u89e3\u51b3\u4e86\u7ea630%\u7684\u7ec6\u80de\u6b7b\u4ea1\uff0c\u5176\u4f59\u6b7b\u4ea1\u673a\u5236\uff08\u5982\u79fb\u690d\u8fc7\u7a0b\u4e2d\u7684\u7f3a\u6c27\u5e94\u6fc0\uff09\u9700\u8981\u8fdb\u4e00\u6b65\u9610\u660e\u3002<\/p>\n<p>\u5176\u6b21\uff0c\u9700\u8981\u4f18\u5316TNF\u03b1\u6291\u5236\u5242\u7684\u6700\u4f73\u7ed9\u836f\u65b9\u6848\uff08\u65f6\u673a\u3001\u5242\u91cf\u3001\u7597\u7a0b\uff09\u3002<\/p>\n<p>\u6700\u540e\uff0c\u63a2\u7d22\u5c06\u4e0a\u8ff0\u7b56\u7565\u4e0e\u795e\u7ecf\u8425\u517b\u56e0\u5b50\u8f93\u9001\u3001\u6216\u4e0e\u5177\u6709\u514d\u75ab\u8c03\u8282\u529f\u80fd\u7684\u7ec6\u80de\uff08\u5982\u8c03\u8282\u6027T\u7ec6\u80de\uff09\u5171\u79fb\u690d\u7b49\u8054\u5408\u65b9\u6848\uff0c\u6709\u671b\u8fdb\u4e00\u6b65\u4f18\u5316\u79fb\u690d\u5fae\u73af\u5883\uff0c\u5b9e\u73b0\u5b58\u6d3b\u7387\u7684\u9636\u68af\u5f0f\u63d0\u5347\u3002<\/p>\n<h2 id=\"jcl-p-7-2\" class=\"wp-block-heading ftwp-heading\"><span class=\"ez-toc-section\" id=\"%E7%BB%93%E8%AE%BA\"><\/span><strong>reach a verdict<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p id=\"JCL-P-7\">\u7efc\u4e0a\u6240\u8ff0\uff0c\u901a\u8fc7\u7cbe\u51c6\u89e3\u6790\u79fb\u690d\u540eDA\u795e\u7ecf\u5143\u6b7b\u4ea1\u7684\u6838\u5fc3\u901a\u8def\uff08TNF\u03b1-NF\u03baB-p53\u8f74\uff09\uff0c\u5e76\u636e\u6b64\u5f00\u53d1\u51fa\u836f\u7406\u5b66\u5e72\u9884\u4e0e\u7ec6\u80de\u4ea7\u54c1\u5de5\u7a0b\u5316\u7684\u53cc\u8f68\u7b56\u7565\uff0c\u6211\u4eec\u4e3a\u7a81\u7834\u5e15\u91d1\u68ee\u75c5\u5e72\u7ec6\u80de\u7597\u6cd5\u5b58\u6d3b\u7387\u4f4e\u7684\u74f6\u9888\u63d0\u4f9b\u4e86\u6e05\u6670\u3001\u53ef\u8f6c\u5316\u7684\u8def\u5f84\u3002\u8fd9\u4e9b\u8fdb\u5c55\u4e0d\u4ec5\u63a8\u52a8\u4e86PD\u7ec6\u80de\u6cbb\u7597\u5411\u4e34\u5e8a\u73b0\u5b9e\u8fc8\u8fdb\uff0c\u4e5f\u4e3a\u6574\u4e2a\u7ec6\u80de\u66ff\u4ee3\u6cbb\u7597\u9886\u57df\u6811\u7acb\u4e86\u653b\u514b\u79fb\u690d\u5b58\u6d3b\u96be\u9898\u7684\u5178\u8303\u3002<\/p>\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\" style=\"font-size:12px\">","protected":false},"excerpt":{"rendered":"<p>[db:\u63cf\u8ff0]<\/p>","protected":false},"author":2,"featured_media":21347,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"image","meta":{"footnotes":""},"categories":[76],"tags":[269],"_links":{"self":[{"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/posts\/21350"}],"collection":[{"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/comments?post=21350"}],"version-history":[{"count":0,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/posts\/21350\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/media\/21347"}],"wp:attachment":[{"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/media?parent=21350"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/categories?post=21350"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/tags?post=21350"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}