{"id":21678,"date":"2026-02-05T18:09:30","date_gmt":"2026-02-05T10:09:30","guid":{"rendered":"https:\/\/www.hjtdsm.cn\/?p=21678"},"modified":"2026-02-05T18:10:04","modified_gmt":"2026-02-05T10:10:04","slug":"https-www-hjtdsm-cn-stem-cells-stem-cell-therapy-21678-html","status":"publish","type":"post","link":"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/21678.html","title":{"rendered":"\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u5916\u6ccc\u4f53\u6cbb\u7597\u81ea\u95ed\u75c7\u8c31\u7cfb\u969c\u788d\uff1a\u4f5c\u7528\u673a\u5236\u3001\u7814\u7a76\u8fdb\u5c55\u4e0e\u4e34\u5e8a\u8f6c\u5316\u524d\u666f"},"content":{"rendered":"<section data-role=\"outer\" data-pm-slice=\"0 0 []\">\n<section data-role=\"paragraph\">\n<section data-role=\"outer\" data-pm-slice=\"0 0 []\">\n<section data-role=\"paragraph\">\n<blockquote><p>\u81ea\u95ed\u75c7\u8c31\u7cfb\u969c\u788d\uff08ASD\uff09\u662f\u4e00\u79cd\u590d\u6742\u7684\u795e\u7ecf\u53d1\u80b2\u969c\u788d\uff0c\u5176\u7279\u5f81\u8868\u73b0\u4e3a\u663e\u8457\u7684\u9057\u4f20\u5f02\u8d28\u6027\u548c\u591a\u79cd\u73af\u5883\u56e0\u7d20\u7684\u5171\u540c\u5f71\u54cd\u3002\u76ee\u524d\u7684\u6cbb\u7597\u65b9\u6cd5\u4e3b\u8981\u96c6\u4e2d\u4e8e\u75c7\u72b6\u7ba1\u7406\uff0c\u800c\u9488\u5bf9\u75be\u75c5\u6f5c\u5728\u75c5\u56e0\u7684\u6709\u6548\u5e72\u9884\u624b\u6bb5\u4ecd\u5341\u5206\u6709\u9650\u3002\u8fd1\u5e74\u6765\uff0c\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09\u53ca\u5176\u884d\u751f\u7684\u5916\u6ccc\u4f53\uff08MSC-Exos\uff09\u56e0\u5176\u5f3a\u5927\u7684\u514d\u75ab\u8c03\u8282\u3001\u795e\u7ecf\u4fdd\u62a4\u548c\u9776\u5411\u9012\u9001\u7279\u6027\uff0c\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u5916\u6ccc\u4f53\u6cbb\u7597\u81ea\u95ed\u75c7\u5df2\u6210\u4e3aASD\u6cbb\u7597\u9886\u57df\u5907\u53d7\u5173\u6ce8\u7684\u6f5c\u5728\u5019\u9009\u7b56\u7565\u3002<\/p><\/blockquote>\n<h2><span 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href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/21678.html\/#%E9%97%B4%E5%85%85%E8%B4%A8%E5%B9%B2%E7%BB%86%E8%83%9E%E5%8F%8A%E5%85%B6%E8%A1%8D%E7%94%9F%E7%9A%84%E5%A4%96%E6%B3%8C%E4%BD%93%E5%9C%A8%E8%87%AA%E9%97%AD%E7%97%87%E8%B0%B1%E7%B3%BB%E9%9A%9C%E7%A2%8D%E4%B8%AD%E7%9A%84%E4%BD%9C%E7%94%A8%EF%BC%9A%E7%A0%94%E7%A9%B6%E4%B8%8E%E5%BA%94%E7%94%A8\" >\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u53ca\u5176\u884d\u751f\u7684\u5916\u6ccc\u4f53\u5728\u81ea\u95ed\u75c7\u8c31\u7cfb\u969c\u788d\u4e2d\u7684\u4f5c\u7528\uff1a\u7814\u7a76\u4e0e\u5e94\u7528<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/21678.html\/#%E9%97%B4%E5%85%85%E8%B4%A8%E5%B9%B2%E7%BB%86%E8%83%9E%E7%9A%84%E7%94%9F%E7%89%A9%E5%AD%A6%E7%89%B9%E6%80%A7%E5%92%8C%E5%85%8D%E7%96%AB%E8%B0%83%E8%8A%82%E4%BD%9C%E7%94%A8%E6%9C%BA%E5%88%B6\" 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>\u5e72\u7ec6\u80de\u548c\u5916\u6ccc\u4f53\u6cbb\u7597\u81ea\u95ed\u75c7\u8c31\u7cfb\u969c\u788d\u4e2d\u7684\u4e34\u5e8a\u8fdb\u5c55<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/21678.html\/#%E4%B8%B4%E5%BA%8A%E7%A0%94%E7%A9%B6%E7%8E%B0%E7%8A%B6%E5%8F%8A%E4%B8%BB%E8%A6%81%E5%8F%91%E7%8E%B0\" >\u4e34\u5e8a\u7814\u7a76\u73b0\u72b6\u53ca\u4e3b\u8981\u53d1\u73b0<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/21678.html\/#%E5%B9%B2%E7%BB%86%E8%83%9E%E5%A4%96%E6%B3%8C%E4%BD%93%E6%B2%BB%E7%96%97%E8%87%AA%E9%97%AD%E7%97%87%E7%9A%84%E6%A0%B8%E5%BF%83%E4%BC%98%E5%8A%BF%E5%92%8C%E5%A4%9A%E6%96%B9%E9%9D%A2%E6%9C%BA%E5%88%B6\" >\u5e72\u7ec6\u80de\u5916\u6ccc\u4f53\u6cbb\u7597\u81ea\u95ed\u75c7\u7684\u6838\u5fc3\u4f18\u52bf\u548c\u591a\u65b9\u9762\u673a\u5236<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/21678.html\/#%E6%A0%B8%E5%BF%83%E4%BC%98%E5%8A%BF%E5%92%8C%E5%A4%9A%E6%96%B9%E9%9D%A2%E6%9C%BA%E5%88%B6\" >\u6838\u5fc3\u4f18\u52bf\u548c\u591a\u65b9\u9762\u673a\u5236<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/21678.html\/#%E7%BB%93%E8%AE%BA\" >reach a verdict<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-16\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/21678.html\/#%E6%9C%AA%E6%9D%A5%E6%8A%80%E6%9C%AF%E5%88%9B%E6%96%B0%E6%96%B9%E5%90%91\" >\u672a\u6765\u6280\u672f\u521b\u65b0\u65b9\u5411<\/a><\/li><\/ul><\/li><\/ul><\/nav><\/div>\n\n<p>\u8fd1\u671f\uff0c\u300a\u56fd\u9645\u5206\u5b50\u533b\u5b66\u6742\u5fd7\u300b\u53d1\u8868\u7684\u4e00\u7bc7\u9898\u4e3a\u201c\u5229\u7528\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6765\u6e90\u7684\u5916\u6ccc\u4f53\u8c03\u8282\u81ea\u95ed\u75c7\u8c31\u7cfb\u969c\u788d\u7684\u75c5\u7406\u751f\u7406\uff1a\u6700\u65b0\u8fdb\u5c55\u548c\u6cbb\u7597\u610f\u4e49\u201d\u7684\u7efc\u8ff0\u6587\u7ae0\uff0c\u7cfb\u7edf\u603b\u7ed3\u4e86MSC-Exos\u7684\u529f\u80fd\u53ca\u5176\u5728ASD\u6cbb\u7597\u4e2d\u7684\u6f5c\u5728\u5e94\u7528\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-21688 size-full\" title=\"\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u5916\u6ccc\u4f53\u6cbb\u7597\u81ea\u95ed\u75c7\u8c31\u7cfb\u969c\u788d\uff1a\u4f5c\u7528\u673a\u5236\u3001\u7814\u7a76\u8fdb\u5c55\u4e0e\u4e34\u5e8a\u8f6c\u5316\u524d\u666f\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2026\/02\/ScreenShot_2026-02-05_145135_704.png\" alt=\"\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u5916\u6ccc\u4f53\u6cbb\u7597\u81ea\u95ed\u75c7\u8c31\u7cfb\u969c\u788d\uff1a\u4f5c\u7528\u673a\u5236\u3001\u7814\u7a76\u8fdb\u5c55\u4e0e\u4e34\u5e8a\u8f6c\u5316\u524d\u666f\" width=\"1760\" height=\"492\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2026\/02\/ScreenShot_2026-02-05_145135_704.png 1760w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2026\/02\/ScreenShot_2026-02-05_145135_704-300x84.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2026\/02\/ScreenShot_2026-02-05_145135_704-1024x286.png 1024w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2026\/02\/ScreenShot_2026-02-05_145135_704-768x215.png 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2026\/02\/ScreenShot_2026-02-05_145135_704-1536x429.png 1536w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2026\/02\/ScreenShot_2026-02-05_145135_704-18x5.png 18w\" sizes=\"(max-width: 1760px) 100vw, 1760px\" \/><\/p>\n<p>\u6587\u7ae0\u6307\u51fa\uff0cMSC-Exos\u901a\u8fc7\u9012\u9001\u591a\u79cd\u751f\u7269\u6d3b\u6027\u5206\u5b50\uff0c\u80fd\u591f\u6709\u6548\u6539\u5584\u81ea\u95ed\u75c7\u60a3\u8005\u7684\u795e\u7ecf\u708e\u75c7\u3001\u589e\u5f3a\u7a81\u89e6\u53ef\u5851\u6027\uff0c\u5e76\u6709\u52a9\u4e8e\u6062\u590d\u795e\u7ecf\u7f51\u7edc\u529f\u80fd\u3002\u6b64\u5916\uff0cMSC-Exos\u8fd8\u5177\u6709\u4f4e\u514d\u75ab\u539f\u6027\u3001\u826f\u597d\u7684\u5b89\u5168\u6027\u4ee5\u53ca\u6613\u4e8e\u89c4\u6a21\u5316\u751f\u4ea7\u7b49\u7a81\u51fa\u4f18\u70b9[1]\u3002<\/p>\n<p>\u603b\u800c\u8a00\u4e4b\uff0cMSC-Exos\u4ee3\u8868\u4e86\u4e00\u79cd\u7a81\u7834\u6027\u7684\u65e0\u7ec6\u80de\u6cbb\u7597\u7b56\u7565\uff0c\u5177\u6709\u9776\u5411\u5e72\u9884ASD\u6838\u5fc3\u75c5\u7406\u751f\u7406\u673a\u5236\u7684\u5de8\u5927\u6f5c\u529b\u3002\u672a\u6765\uff0c\u5f00\u5c55\u591a\u4e2d\u5fc3\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\u5e76\u52a0\u5f3a\u8de8\u5b66\u79d1\u5408\u4f5c\uff0c\u5bf9\u4e8e\u5c06\u4e34\u5e8a\u524d\u7814\u7a76\u6210\u679c\u8f6c\u5316\u4e3a\u6709\u6548\u4e14\u5177\u6709\u53d8\u9769\u610f\u4e49\u7684ASD\u7597\u6cd5\u81f3\u5173\u91cd\u8981\u3002<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%E8%87%AA%E9%97%AD%E7%97%87%E8%B0%B1%E7%B3%BB%E9%9A%9C%E7%A2%8D%E7%9A%84%E5%88%86%E5%AD%90%E9%81%97%E4%BC%A0%E5%AD%A6%E5%92%8C%E7%A5%9E%E7%BB%8F%E7%97%85%E7%90%86%E5%AD%A6\"><\/span><strong>\u81ea\u95ed\u75c7\u8c31\u7cfb\u969c\u788d\u7684\u5206\u5b50\u9057\u4f20\u5b66\u548c\u795e\u7ecf\u75c5\u7406\u5b66<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>\u968f\u7740\u5bf9\u81ea\u95ed\u75c7\u8c31\u7cfb\u969c\u788d\u8ba4\u8bc6\u7684\u4e0d\u65ad\u6df1\u5165\uff0c\u5176\u75c5\u56e0\u4e0e\u53d1\u75c5\u673a\u5236\u7684\u7814\u7a76\u5df2\u4ece\u65e9\u671f\u7b80\u5355\u7684\u9057\u4f20\u5173\u8054\u5206\u6790\uff0c\u9010\u6b65\u6269\u5c55\u5230\u6db5\u76d6\u5206\u5b50\u75c5\u7406\u5b66\u3001\u795e\u7ecf\u7f51\u7edc\u7d0a\u4e71\u53ca\u591a\u5b66\u79d1\u4ea4\u53c9\u7684\u7efc\u5408\u6846\u67b6\u3002\u8fd1\u5e74\u6765\uff0c\u9ad8\u901a\u91cf\u5355\u7ec6\u80de\u6d4b\u5e8f\u548c\u8111\u7c7b\u5668\u5b98\u6a21\u578b\u7b49\u65b0\u5174\u6280\u672f\u7684\u8fc5\u901f\u53d1\u5c55\uff0c\u4e3a\u6df1\u5165\u89e3\u6790 ASD \u4e2d\u57fa\u56e0\u2011\u73af\u5883\u76f8\u4e92\u4f5c\u7528\u53ca\u795e\u7ecf\u53d1\u80b2\u5f02\u5e38\u63d0\u4f9b\u4e86\u6709\u529b\u5de5\u5177\u3002<\/p>\n<p>\u8fd9\u4e9b\u8fdb\u5c55\u4e5f\u4e3a\u5f00\u53d1\u65b0\u7684\u5e72\u9884\u4e0e\u6cbb\u7597\u9014\u5f84\u5960\u5b9a\u4e86\u7406\u8bba\u57fa\u7840\u3002\u5728\u6b64\u80cc\u666f\u4e0b\uff0c\u4e0b\u6587\u5c06\u7cfb\u7edf\u56de\u987e\u5f53\u524dASD\u7684\u7814\u7a76\u73b0\u72b6\uff0c\u91cd\u70b9\u5173\u6ce8\u5176\u9057\u4f20\u56fe\u8c31\u3001\u7a81\u89e6\u5931\u8861\u3001\u708e\u75c7\u8c03\u63a7\u3001\u80f6\u8d28\u7ec6\u80de\u6d3b\u5316\u53ca\u514d\u75ab\u5931\u8c03\u7b49\u6838\u5fc3\u65b9\u9762\u3002<\/p>\n<section><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-21679 aligncenter\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2026\/02\/75f5e71c-9950-4239-9a5b-24bd54f3a6c5.png\" alt=\"\" width=\"1024\" height=\"1536\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2026\/02\/75f5e71c-9950-4239-9a5b-24bd54f3a6c5.png 1024w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2026\/02\/75f5e71c-9950-4239-9a5b-24bd54f3a6c5-200x300.png 200w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2026\/02\/75f5e71c-9950-4239-9a5b-24bd54f3a6c5-683x1024.png 683w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2026\/02\/75f5e71c-9950-4239-9a5b-24bd54f3a6c5-768x1152.png 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2026\/02\/75f5e71c-9950-4239-9a5b-24bd54f3a6c5-8x12.png 8w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/section>\n<p>\u56fe\u6e90\uff1aAI\u751f\u6210<\/p>\n<h3><span class=\"ez-toc-section\" id=\"%E8%87%AA%E9%97%AD%E7%97%87%E8%B0%B1%E7%B3%BB%E9%9A%9C%E7%A2%8D%E7%9A%84%E9%81%97%E4%BC%A0%E7%89%B9%E5%BE%81%E5%92%8C%E5%A4%9A%E5%9F%BA%E5%9B%A0%E5%A4%8D%E6%9D%82%E6%80%A7\"><\/span><strong>\u81ea\u95ed\u75c7\u8c31\u7cfb\u969c\u788d\u7684\u9057\u4f20\u7279\u5f81\u548c\u591a\u57fa\u56e0\u590d\u6742\u6027<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u81ea\u95ed\u75c7\u8c31\u7cfb\u969c\u788d\uff08ASD\uff09\u5177\u6709\u663e\u8457\u7684\u9057\u4f20\u57fa\u7840\uff0c\u9057\u4f20\u56e0\u7d20\u5728\u5176\u4e2d\u5360\u636e\u4e3b\u5bfc\u4f5c\u7528\u3002\u53cc\u751f\u5b50\u7814\u7a76\u4e3a\u6b64\u63d0\u4f9b\u4e86\u5173\u952e\u8bc1\u636e\uff1a\u5355\u5375\u53cc\u751f\u5b50\uff08MZ\uff09\u7684ASD\u4e00\u81f4\u7387\uff08\u7ea658-98%\uff09\u8fdc\u9ad8\u4e8e\u53cc\u5375\u53cc\u751f\u5b50\uff08DZ\uff0c\u7ea621-36%\uff09\uff0c\u8fd9\u8868\u660e\u9057\u4f20\u7387\u4f30\u8ba1\u503c\u53ef\u9ad8\u8fbe64-91%\u3002\u8fd9\u79cd\u5de8\u5927\u7684\u5dee\u5f02\u51f8\u663e\u4e86\u9057\u4f20\u56e0\u7d20\u5728ASD\u53d1\u75c5\u4e2d\u7684\u6838\u5fc3\u5730\u4f4d\uff0c\u800c\u5171\u540c\u73af\u5883\u56e0\u7d20\u7684\u4f5c\u7528\u5219\u76f8\u5bf9\u8f83\u5c0f\u4e14\u5bf9\u6a21\u578b\u5047\u8bbe\u8f83\u4e3a\u654f\u611f\u3002<\/p>\n<p>ASD\u7684\u9057\u4f20\u7ed3\u6784\u5177\u6709\u9ad8\u5ea6\u591a\u57fa\u56e0\u6027\u548c\u5f02\u8d28\u6027\uff0c\u6d89\u53ca\u591a\u79cd\u7c7b\u578b\u7684\u9057\u4f20\u53d8\u5f02\u3002\u5927\u89c4\u6a21\u7684\u57fa\u56e0\u7814\u7a76\u5df2\u9274\u5b9a\u51fa\u6570\u767e\u4e2a\u76f8\u5173\u57fa\u56e0\u4f4d\u70b9\uff0c\u5305\u62ecCHD8\u3001NRXN1\u3001SHANK3\u3001CNTNAP2\u7b49\u5173\u952e\u57fa\u56e0\uff0c\u5b83\u4eec\u4e3b\u8981\u53c2\u4e0e\u67d3\u8272\u8d28\u91cd\u5851\u3001\u7a81\u89e6\u5f62\u6210\u4e0e\u529f\u80fd\u7b49\u795e\u7ecf\u53d1\u80b2\u8fc7\u7a0b\u3002\u98ce\u9669\u65e2\u6765\u81ea\u9ad8\u5916\u663e\u7387\u7684\u7f55\u89c1\u53d8\u5f02\uff08\u5982\u65b0\u751f\u86cb\u767d\u8d28\u622a\u65ad\u53d8\u5f02\u3001\u6709\u5bb3\u9519\u4e49\u53d8\u5f02\u548c\u62f7\u8d1d\u6570\u53d8\u5f02\uff09\uff0c\u4e5f\u6765\u81ea\u4f17\u591a\u5e38\u89c1\u53d8\u5f31\u7684\u7d2f\u79ef\u6548\u5e94\u3002\u5176\u4e2d\uff0c\u62f7\u8d1d\u6570\u53d8\u5f02\uff08CNV\uff09\u5c24\u4e3a\u91cd\u8981\uff0c\u5b83\u4eec\u901a\u8fc7\u6539\u53d8\u57fa\u56e0\u5242\u91cf\u3001\u5f71\u54cd\u591a\u4e2a\u57fa\u56e0\u5e76\u7834\u574f\u8c03\u63a7\u7f51\u7edc\uff0c\u5e26\u6765\u4e86\u6781\u9ad8\u7684\u76f8\u5bf9\u98ce\u9669\uff0c\u8fd9\u89e3\u91ca\u4e86ASD\u5728\u9057\u4f20\u4e0a\u7684\u6781\u7aef\u590d\u6742\u6027\u3002<\/p>\n<p>\u8fd9\u4e9b\u9057\u4f20\u98ce\u9669\u56e0\u7d20\u5728\u795e\u7ecf\u53d1\u80b2\u7684\u4e0d\u540c\u9636\u6bb5\u548c\u4e0d\u540c\u7ec6\u80de\u7c7b\u578b\u4e2d\u53d1\u6325\u7279\u5f02\u6027\u4f5c\u7528\uff0c\u6784\u6210\u4e86ASD\u7684\u591a\u57fa\u56e0\u590d\u6742\u6027\u3002\u4e0eASD\u5f3a\u76f8\u5173\u7684\u57fa\u56e0\u503e\u5411\u4e8e\u5728\u6210\u719f\u795e\u7ecf\u5143\u4e2d\u9ad8\u8868\u8fbe\uff0c\u5f71\u54cd\u7a81\u89e6\u8fde\u63a5\u548c\u795e\u7ecf\u73af\u8def\u529f\u80fd\uff1b\u800c\u4e0e\u4e00\u822c\u6027\u53d1\u80b2\u8fdf\u7f13\u76f8\u5173\u7684\u57fa\u56e0\u5219\u66f4\u591a\u5728\u672a\u6210\u719f\u7684\u795e\u7ecf\u7956\u7ec6\u80de\u4e2d\u6d3b\u8dc3\u3002\u8fd9\u79cd\u65f6\u7a7a\u8868\u8fbe\u7279\u5f02\u6027\u610f\u5473\u7740\uff0cASD\u7684\u9057\u4f20\u98ce\u9669\u662f\u901a\u8fc7\u4e00\u4e2a\u5e9e\u5927\u800c\u76f8\u4e92\u5173\u8054\u7684\u57fa\u56e0\u7f51\u7edc\u5728\u7279\u5b9a\u53d1\u80b2\u7a97\u53e3\u671f\u88ab\u89e6\u53d1\u7684\uff0c\u6700\u7ec8\u5bfc\u81f4\u793e\u4ea4\u6c9f\u901a\u969c\u788d\u3001\u91cd\u590d\u884c\u4e3a\u7b49\u6838\u5fc3\u8868\u578b\u3002\u56e0\u6b64\uff0cASD\u5e76\u975e\u7531\u5355\u4e00\u57fa\u56e0\u7f3a\u9677\u5f15\u8d77\uff0c\u800c\u662f\u591a\u57fa\u56e0\u53d8\u5f02\u4e0e\u73af\u5883\u56e0\u7d20\u590d\u6742\u4e92\u52a8\u7684\u7ed3\u679c\u3002<\/p>\n<h3><span 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class=\"ez-toc-section\" id=\"%E8%87%AA%E9%97%AD%E7%97%87%E8%B0%B1%E7%B3%BB%E9%9A%9C%E7%A2%8D%E7%A5%9E%E7%BB%8F%E7%82%8E%E7%97%87%E7%9A%84%E7%BB%86%E8%83%9E%E5%AD%A6%E5%9F%BA%E7%A1%80\"><\/span><strong>\u81ea\u95ed\u75c7\u8c31\u7cfb\u969c\u788d\u795e\u7ecf\u708e\u75c7\u7684\u7ec6\u80de\u5b66\u57fa\u7840<\/strong><span 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class=\"wp-caption-text\">\u56fe1\uff1a\u81ea\u95ed\u75c7\u8c31\u7cfb\u969c\u788d\u60a3\u8005\u5927\u8111\u4e2d\u5c0f\u80f6\u8d28\u7ec6\u80de\u3001\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u548c\u795e\u7ecf\u5143\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u3002M1\u578b\u5c0f\u80f6\u8d28\u7ec6\u80de\u548cA1\u578b\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u91ca\u653e\u4fc3\u708e\u7ec6\u80de\u56e0\u5b50\uff08\u4f8b\u5982TNF-\u03b1\u3001IL-1\u03b2\u548cIL-6\uff09\uff0c\u8fd9\u4e9b\u7ec6\u80de\u56e0\u5b50\u4f1a\u52a0\u5267\u795e\u7ecf\u708e\u75c7\u5e76\u8bf1\u5bfc\u7a81\u89e6\u635f\u4f24\u3002\u76f8\u53cd\uff0cM2\u578b\u5c0f\u80f6\u8d28\u7ec6\u80de\u548cA2\u578b\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u5206\u6ccc\u6297\u708e\u56e0\u5b50\u548c\u795e\u7ecf\u8425\u517b\u56e0\u5b50\uff08\u4f8b\u5982IL-10\u3001TGF-\u03b2\u3001BDNF\u548cCNTF\uff09\uff0c\u4ece\u800c\u4fc3\u8fdb\u7a81\u89e6\u4fee\u590d\u3001\u8840\u8111\u5c4f\u969c\u7a33\u5b9a\u6027\u548c\u4f53\u5185\u5e73\u8861\u3002<\/p><\/div>\n<\/section>\n<h2><span class=\"ez-toc-section\" id=\"%E9%97%B4%E5%85%85%E8%B4%A8%E5%B9%B2%E7%BB%86%E8%83%9E%E5%8F%8A%E5%85%B6%E8%A1%8D%E7%94%9F%E7%9A%84%E5%A4%96%E6%B3%8C%E4%BD%93%E5%9C%A8%E8%87%AA%E9%97%AD%E7%97%87%E8%B0%B1%E7%B3%BB%E9%9A%9C%E7%A2%8D%E4%B8%AD%E7%9A%84%E4%BD%9C%E7%94%A8%EF%BC%9A%E7%A0%94%E7%A9%B6%E4%B8%8E%E5%BA%94%E7%94%A8\"><\/span><strong>\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u53ca\u5176\u884d\u751f\u7684\u5916\u6ccc\u4f53\u5728\u81ea\u95ed\u75c7\u8c31\u7cfb\u969c\u788d\u4e2d\u7684\u4f5c\u7528\uff1a\u7814\u7a76\u4e0e\u5e94\u7528<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<h3><span class=\"ez-toc-section\" id=\"%E9%97%B4%E5%85%85%E8%B4%A8%E5%B9%B2%E7%BB%86%E8%83%9E%E7%9A%84%E7%94%9F%E7%89%A9%E5%AD%A6%E7%89%B9%E6%80%A7%E5%92%8C%E5%85%8D%E7%96%AB%E8%B0%83%E8%8A%82%E4%BD%9C%E7%94%A8%E6%9C%BA%E5%88%B6\"><\/span>\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u7684\u751f\u7269\u5b66\u7279\u6027\u548c\u514d\u75ab\u8c03\u8282\u4f5c\u7528\u673a\u5236<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><a href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/novel-stem-cell-therapy\/21672.html\/\" target=\"_blank\" rel=\"noopener\">\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09<\/a>\u662f\u5177\u6709\u591a\u5411\u5206\u5316\u6f5c\u80fd\u548c\u81ea\u6211\u66f4\u65b0\u80fd\u529b\u7684\u6210\u4f53\u5e72\u7ec6\u80de\uff0c\u6700\u521d\u7531Friedenstein\u7b49\u4eba\u5728\u9aa8\u9ad3\u4e2d\u53d1\u73b0\u3002\u8fd9\u4e9b\u7ec6\u80de\u80fd\u591f\u9ecf\u9644\u4e8e\u5851\u6599\u57f9\u517b\u74f6\uff0c\u5e76\u8868\u73b0\u51fa\u5f3a\u5927\u7684\u751f\u7269\u5b66\u529f\u80fd\u3002\u5b83\u4eec\u5e7f\u6cdb\u5206\u5e03\u4e8e\u5404\u79cd\u7ec4\u7ec7\u4e2d\uff0c\u4f8b\u5982\u9aa8\u9ad3\u3001\u8102\u80aa\u7ec4\u7ec7\u3001\u8110\u5e26\u3001\u80ce\u76d8\u548c\u7259\u9ad3\u3002MSCs\u6765\u6e90\u7684\u793a\u610f\u56fe\u5982\u56fe\u6240\u793a\u3002\u56fe2\u7531\u4e8e\u5176\u6765\u6e90\u591a\u6837\u4e14\u529f\u80fd\u7279\u6027\u72ec\u7279\uff0c\u7ec6\u80de\u5df2\u6210\u4e3a\u518d\u751f\u533b\u5b66\u548c\u7ec6\u80de\u6cbb\u7597\u9886\u57df\u7684\u91cd\u8981\u7814\u7a76\u91cd\u70b9\u3002<\/p>\n<section>\n<div id=\"attachment_21686\" style=\"width: 2041px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-21686\" class=\"wp-image-21686 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2026\/02\/ijmm-57-03-05731-g01.jpg\" alt=\"\" width=\"2031\" height=\"1435\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2026\/02\/ijmm-57-03-05731-g01.jpg 2031w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2026\/02\/ijmm-57-03-05731-g01-300x212.jpg 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2026\/02\/ijmm-57-03-05731-g01-1024x724.jpg 1024w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2026\/02\/ijmm-57-03-05731-g01-768x543.jpg 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2026\/02\/ijmm-57-03-05731-g01-1536x1085.jpg 1536w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2026\/02\/ijmm-57-03-05731-g01-18x12.jpg 18w\" sizes=\"(max-width: 2031px) 100vw, 2031px\" \/><p id=\"caption-attachment-21686\" class=\"wp-caption-text\">\u56fe2\uff1a\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u7684\u6765\u6e90\u3002\u6210\u4eba\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u53ef\u6765\u6e90\u4e8e\u9aa8\u9ad3\u3001\u8102\u80aa\u7ec4\u7ec7\u3001\u5916\u5468\u8840\u3001\u9aa8\u9abc\u808c\u548c\u7259\u9ad3\u3002\u56f4\u4ea7\u671f\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u901a\u5e38\u53d6\u81ea\u80ce\u76d8\u3001\u8110\u5e26\u3001\u8110\u5e26\u8840\u3001\u7f8a\u6c34\u548c\u7f8a\u819c\u3002<\/p><\/div>\n<\/section>\n<h3><span class=\"ez-toc-section\" id=\"%E9%97%B4%E5%85%85%E8%B4%A8%E5%B9%B2%E7%BB%86%E8%83%9E%E5%A4%96%E6%B3%8C%E4%BD%93%E6%B2%BB%E7%96%97%E8%87%AA%E9%97%AD%E7%97%87%E8%B0%B1%E7%B3%BB%E9%9A%9C%E7%A2%8D%E4%B8%AD%E7%9A%84%E7%A0%94%E7%A9%B6%E8%BF%9B%E5%B1%95\"><\/span>\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u5916\u6ccc\u4f53\u6cbb\u7597\u81ea\u95ed\u75c7\u8c31\u7cfb\u969c\u788d\u4e2d\u7684\u7814\u7a76\u8fdb\u5c55<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u5728\u81ea\u95ed\u75c7\u8c31\u7cfb\u969c\u788d\u4e2d\u7684\u7814\u7a76\u8fdb\u5c55\u4e3b\u8981\u4f53\u73b0\u5728\u5176\u6cbb\u7597\u6f5c\u529b\u4e0e\u4f5c\u7528\u673a\u5236\u7684\u63a2\u7d22\uff0c\u4ee5\u53ca\u65b0\u578b\u6cbb\u7597\u7b56\u7565\u7684\u884d\u751f\u4e0a\u3002<\/p>\n<p>\u4e00\u65b9\u9762\uff0c\u4e34\u5e8a\u524d\u7814\u7a76\u8868\u660eMSCs\u79fb\u690d\u5bf9\u6539\u5584ASD\u6838\u5fc3\u884c\u4e3a\u75c7\u72b6\u5177\u6709\u6f5c\u529b\u3002\u5728\u4e19\u620a\u9178\u8bf1\u5bfc\u7684ASD\u5927\u9f20\u6a21\u578b\u4e2d\uff0cMSCs\u79fb\u690d\u80fd\u591f\u663e\u8457\u6539\u5584\u52a8\u7269\u7684\u793e\u4ea4\u4e92\u52a8\u3001\u51cf\u8f7b\u91cd\u590d\u523b\u677f\u884c\u4e3a\u5e76\u7f13\u89e3\u7126\u8651\u3002\u5176\u4f5c\u7528\u673a\u5236\u4e3b\u8981\u5f52\u56e0\u4e8eMSCs\u591a\u91cd\u7684\u795e\u7ecf\u4fdd\u62a4\u4e0e\u514d\u75ab\u8c03\u8282\u529f\u80fd\uff1a\u901a\u8fc7\u5206\u6ccc\u8111\u6e90\u6027\u795e\u7ecf\u8425\u517b\u56e0\u5b50\u7b49\u795e\u7ecf\u8425\u517b\u56e0\u5b50\uff0c\u6fc0\u6d3bPI3K\/Akt\u7b49\u4fe1\u53f7\u901a\u8def\u4ee5\u589e\u5f3a\u795e\u7ecf\u5143\u5b58\u6d3b\u4e0e\u7a81\u89e6\u53ef\u5851\u6027\uff1b\u540c\u65f6\uff0c\u6709\u6548\u51cf\u8f7b\u795e\u7ecf\u708e\u75c7\u548c\u6c27\u5316\u5e94\u6fc0\uff0c\u4ece\u800c\u4ece\u591a\u4e2a\u5c42\u9762\u6539\u5584ASD\u76f8\u5173\u7684\u795e\u7ecf\u75c5\u7406\u73af\u5883\u3002<\/p>\n<p>\u53e6\u4e00\u65b9\u9762\uff0c\u4e3a\u514b\u670dMSCs\u7ec6\u80de\u7597\u6cd5\u81ea\u8eab\u7684\u5c40\u9650\u6027\uff08\u5982\u514d\u75ab\u6392\u65a5\u3001\u6269\u589e\u80fd\u529b\u4e0b\u964d\uff09\uff0c\u7814\u7a76\u524d\u6cbf\u5df2\u8f6c\u5411\u5176\u884d\u751f\u7684\u5916\u6ccc\u4f53\u3002MSCs\u6765\u6e90\u7684\u5916\u6ccc\u4f53\u4f5c\u4e3a\u4e00\u79cd\u201c\u65e0\u7ec6\u80de\u7597\u6cd5\u201d\uff0c\u7ee7\u627f\u4e86\u6bcd\u7ec6\u80de\u7684\u514d\u75ab\u8c03\u8282\u548c\u7ec4\u7ec7\u4fee\u590d\u529f\u80fd\uff0c\u540c\u65f6\u5177\u6709\u4f53\u79ef\u5c0f\u3001\u514d\u75ab\u539f\u6027\u4f4e\u3001\u6613\u4e8e\u50a8\u5b58\u548c\u6807\u51c6\u5316\u751f\u4ea7\u7b49\u663e\u8457\u4f18\u52bf\u3002\u8fd9\u4e00\u65b0\u7b56\u7565\u4e3a\u63d0\u9ad8ASD\u6cbb\u7597\u7684\u4e34\u5e8a\u8f6c\u5316\u53ef\u884c\u6027\u3001\u53d1\u5c55\u66f4\u5b89\u5168\u7cbe\u51c6\u7684\u5e72\u9884\u624b\u6bb5\u63d0\u4f9b\u4e86\u6781\u5177\u524d\u666f\u7684\u65b0\u65b9\u5411\u3002<\/p>\n<h3><span class=\"ez-toc-section\" id=\"%E5%A4%96%E6%B3%8C%E4%BD%93%E7%9A%84%E7%BB%93%E6%9E%84%E5%92%8C%E7%94%9F%E7%89%A9%E5%AD%A6%E5%8A%9F%E8%83%BD\"><\/span><strong>\u5916\u6ccc\u4f53\u7684\u7ed3\u6784\u548c\u751f\u7269\u5b66\u529f\u80fd<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u5916\u6ccc\u4f53\u662f\u76f4\u5f84\u7ea6\u4e3a30-150nm\u7684\u7ec6\u80de\u5916\u56ca\u6ce1\uff0c\u8d77\u6e90\u4e8e\u5185\u4f53\u9014\u5f84\uff0c\u5e76\u901a\u8fc7\u591a\u56ca\u6ce1\u4f53\u4e0e\u7ec6\u80de\u819c\u878d\u5408\u91ca\u653e\u5230\u4f53\u6db2\u4e2d\u3002\u5916\u6ccc\u4f53\u7531\u8102\u8d28\u53cc\u5c42\u5305\u88f9\uff0c\u5bcc\u542b\u591a\u79cd\u751f\u7269\u6d3b\u6027\u6210\u5206\uff0c\u5305\u62ec\u86cb\u767d\u8d28\u3001\u6838\u9178\uff08mRNA\u3001miRNA\u548clncRNA\u7b49\uff09\u548c\u8102\u8d28\u3002\u5176\u7a33\u5b9a\u7684\u7ed3\u6784\u4f7f\u5916\u6ccc\u4f53\u80fd\u591f\u4f5c\u4e3a\u7ec6\u80de\u95f4\u901a\u8baf\u548c\u8c03\u63a7\u7684\u72ec\u7279\u4ecb\u8d28\uff0c\u4ece\u800c\u4e3a\u6f5c\u5728\u7684\u6cbb\u7597\u5e94\u7528\u63d0\u4f9b\u4e86\u7406\u8bba\u57fa\u7840\u3002<\/p>\n<p>MSC\u6765\u6e90\u7684\u5916\u6ccc\u4f53\u7684\u7ec4\u6210\u548c\u751f\u7269\u53d1\u751f\u9014\u5f84\uff0c\u4ee5\u53ca\u5b83\u4eec\u5728ASD\u6a21\u578b\u4e2d\u5bf9\u795e\u7ecf\u5143\u548c\u80f6\u8d28\u7ec6\u80de\u7684\u4e0b\u6e38\u6548\u5e94\uff0c\u5df2\u5728\u6587\u732e\u4e2d\u8fdb\u884c\u4e86\u603b\u7ed3\u3002\u56fe3\u5916\u6ccc\u4f53\u4e3b\u8981\u901a\u8fc7\u4e0e\u53d7\u4f53\u7ec6\u80de\u5185\u7684\u8f7d\u4f53\u76f8\u4e92\u4f5c\u7528\u53d1\u6325\u5176\u6cbb\u7597\u4f5c\u7528\u3002\u5916\u6ccc\u4f53\u901a\u8fc7\u4e0e\u8d28\u819c\u878d\u5408\u6216\u8fdb\u884c\u53d7\u4f53\u4ecb\u5bfc\u7684\u5185\u541e\u4f5c\u7528\uff0c\u5c06\u5176\u5185\u5bb9\u7269\u76f4\u63a5\u9012\u9001\u81f3\u9776\u7ec6\u80de\uff0c\u4ece\u800c\u8c03\u8282\u57fa\u56e0\u8868\u8fbe\u548c\u4fe1\u53f7\u901a\u8def\u3002<\/p>\n<section>\n<div id=\"attachment_21685\" style=\"width: 2042px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-21685\" class=\"wp-image-21685 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2026\/02\/ijmm-57-03-05731-g02.jpg\" alt=\"\" width=\"2032\" height=\"1529\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2026\/02\/ijmm-57-03-05731-g02.jpg 2032w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2026\/02\/ijmm-57-03-05731-g02-300x226.jpg 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2026\/02\/ijmm-57-03-05731-g02-1024x771.jpg 1024w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2026\/02\/ijmm-57-03-05731-g02-768x578.jpg 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2026\/02\/ijmm-57-03-05731-g02-1536x1156.jpg 1536w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2026\/02\/ijmm-57-03-05731-g02-16x12.jpg 16w\" sizes=\"(max-width: 2032px) 100vw, 2032px\" \/><p id=\"caption-attachment-21685\" class=\"wp-caption-text\">\u56fe3\uff1a\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSC\uff09\u6765\u6e90\u5916\u6ccc\u4f53\u5728\u81ea\u95ed\u75c7\u8c31\u7cfb\u969c\u788d\uff08ASD\uff09\u6cbb\u7597\u4e2d\u7684\u751f\u7269\u53d1\u751f\u3001\u5206\u5b50\u7ec4\u6210\u548c\u673a\u5236\u3002<\/p><\/div>\n<\/section>\n<h3><span class=\"ez-toc-section\" id=\"%E5%A4%96%E6%B3%8C%E4%BD%93%E5%9C%A8%E8%87%AA%E9%97%AD%E7%97%87%E8%B0%B1%E7%B3%BB%E9%9A%9C%E7%A2%8D%E6%B2%BB%E7%96%97%E4%B8%AD%E7%9A%84%E6%BD%9C%E5%9C%A8%E4%BB%B7%E5%80%BC\"><\/span><strong>\u5916\u6ccc\u4f53\u5728\u81ea\u95ed\u75c7\u8c31\u7cfb\u969c\u788d\u6cbb\u7597\u4e2d\u7684\u6f5c\u5728\u4ef7\u503c<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u5916\u6ccc\u4f53\uff0c\u5c24\u5176\u662f\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6765\u6e90\u7684\u5916\u6ccc\u4f53\uff0c\u4f5c\u4e3a\u65b0\u5174\u7684\u201c\u65e0\u7ec6\u80de\u7597\u6cd5\u201d\uff0c\u5728\u81ea\u95ed\u75c7\u8c31\u7cfb\u969c\u788d\u6cbb\u7597\u4e2d\u5c55\u73b0\u51fa\u72ec\u7279\u7684\u6f5c\u5728\u4ef7\u503c\u3002\u76f8\u8f83\u4e8e\u4f20\u7edf\u7684\u5e72\u7ec6\u80de\u79fb\u690d\uff0c\u5916\u6ccc\u4f53\u5177\u6709\u66f4\u9ad8\u7684\u5b89\u5168\u6027\u3001\u66f4\u4f4e\u7684\u514d\u75ab\u539f\u6027\u3001\u6613\u4e8e\u50a8\u5b58\u548c\u6807\u51c6\u5316\u751f\u4ea7\u7b49\u4f18\u52bf\u3002\u5b83\u4eec\u4f5c\u4e3a\u5929\u7136\u7684\u751f\u7269\u9012\u9001\u8f7d\u4f53\uff0c\u5c01\u88c5\u4e86\u591a\u79cd\u5177\u6709\u6cbb\u7597\u6f5c\u529b\u7684\u751f\u7269\u6d3b\u6027\u5206\u5b50\uff0c\u80fd\u591f\u7a7f\u8d8a<a class=\"normal_text_link mp_article_text_link\" href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzkwOTEzMDY0Nw==&amp;mid=2247511161&amp;idx=1&amp;sn=700d2c9cb6a8fbb2f590311e4eb057dc&amp;scene=21#wechat_redirect\" target=\"_blank\" rel=\"noopener nofollow\" data-itemshowtype=\"0\" data-linktype=\"2\">blood-brain barrier<\/a>\uff0c\u5728\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u5185\u7cbe\u51c6\u5730\u53d1\u6325\u514d\u75ab\u8c03\u8282\u3001\u795e\u7ecf\u4fdd\u62a4\u548c\u4fc3\u8fdb\u7a81\u89e6\u4fee\u590d\u7b49\u591a\u91cd\u529f\u80fd\u3002<\/p>\n<p>\u52a8\u7269\u6a21\u578b\u7814\u7a76\u4e3a\u5916\u6ccc\u4f53\u7684\u7597\u6548\u63d0\u4f9b\u4e86\u76f4\u63a5\u8bc1\u636e\u3002\u901a\u8fc7\u9f3b\u5185\u7ed9\u836f\u7b49\u9014\u5f84\u9012\u9001MSC-Exos\uff0c\u80fd\u591f\u663e\u8457\u6539\u5584ASD\u6a21\u578b\u52a8\u7269\u7684\u793e\u4ea4\u7f3a\u9677\u3001\u8ba4\u77e5\u969c\u788d\u548c\u91cd\u590d\u523b\u677f\u884c\u4e3a\u3002\u5176\u4f5c\u7528\u673a\u5236\u5f52\u56e0\u4e8e\u5916\u6ccc\u4f53\u6240\u643a\u5e26\u7684\u7279\u5b9a\u5185\u5bb9\u7269\uff0c\u4f8b\u5982miR-21-5p\u7b49miRNA\u53ef\u8c03\u8282\u795e\u7ecf\u708e\u75c7\u53cd\u5e94\uff0c\u800cHSP70\u3001TGF-\u03b2\u7b49\u86cb\u767d\u8d28\u5219\u80fd\u589e\u5f3a\u7a81\u89e6\u53ef\u5851\u6027\u548c\u795e\u7ecf\u53d1\u751f\u3002\u8fd9\u4e9b\u5206\u5b50\u534f\u540c\u4f5c\u7528\uff0c\u901a\u8fc7\u51cf\u8f7b\u8111\u5185\u708e\u75c7\u3001\u6062\u590d\u5174\u594b\/\u6291\u5236\u5e73\u8861\u3001\u4fc3\u8fdb\u795e\u7ecf\u7f51\u7edc\u529f\u80fd\u6574\u5408\uff0c\u4ece\u800c\u4ece\u75c5\u7406\u6838\u5fc3\u5c42\u9762\u6539\u5584\u884c\u4e3a\u8868\u578b\u3002<\/p>\n<p>\u7efc\u4e0a\u6240\u8ff0\uff0c\u57fa\u4e8e\u5916\u6ccc\u4f53\u4e30\u5bcc\u7684\u6d3b\u6027\u6210\u5206\u548c\u7a33\u5b9a\u7684\u9012\u9001\u7279\u6027\uff0c\u5176\u5728ASD\u6cbb\u7597\u4e2d\u4ee3\u8868\u4e86\u4e00\u79cd\u6781\u5177\u524d\u666f\u7684\u7cbe\u51c6\u5e72\u9884\u7b56\u7565\u3002\u5f53\u524d\u7684\u7814\u7a76\u91cd\u70b9\u6b63\u8f6c\u5411\u6df1\u5165\u9610\u660e\u5176\u5177\u4f53\u4f5c\u7528\u673a\u5236\u3001\u4f18\u5316\u5916\u6ccc\u4f53\u7684\u5236\u5907\u4e0e\u7ed9\u836f\u65b9\u6848\uff0c\u5e76\u901a\u8fc7\u8de8\u5b66\u79d1\u5408\u4f5c\u63a8\u52a8\u5176\u4e34\u5e8a\u8f6c\u5316\u3002\u8fd9\u4e9b\u52aa\u529b\u6709\u671b\u5f00\u53d1\u51fa\u5b89\u5168\u3001\u6709\u6548\u4e14\u53ef\u89c4\u6a21\u5316\u7684\u65b0\u578b\u7597\u6cd5\uff0c\u63a8\u52a8ASD\u6cbb\u7597\u9886\u57df\u5411\u66f4\u7cbe\u51c6\u3001\u66f4\u5b9e\u7528\u7684\u65b9\u5411\u8fc8\u8fdb\u3002<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%E5%B9%B2%E7%BB%86%E8%83%9E%E5%92%8C%E5%A4%96%E6%B3%8C%E4%BD%93%E6%B2%BB%E7%96%97%E8%87%AA%E9%97%AD%E7%97%87%E8%B0%B1%E7%B3%BB%E9%9A%9C%E7%A2%8D%E4%B8%AD%E7%9A%84%E4%B8%B4%E5%BA%8A%E8%BF%9B%E5%B1%95\"><\/span><strong>\u5e72\u7ec6\u80de\u548c\u5916\u6ccc\u4f53\u6cbb\u7597\u81ea\u95ed\u75c7\u8c31\u7cfb\u969c\u788d\u4e2d\u7684\u4e34\u5e8a\u8fdb\u5c55<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>\u8fd1\u5e74\u6765\uff0c\u57fa\u4e8e\u5e72\u7ec6\u80de\u7684\u7597\u6cd5\u5df2\u6210\u4e3a\u81ea\u95ed\u75c7\u8c31\u7cfb\u969c\u788d\u6cbb\u7597\u7684\u5173\u952e\u7814\u7a76\u65b9\u5411\u4e4b\u4e00\u3002\u7814\u7a76\u4eba\u5458\u5229\u7528\u5e72\u7ec6\u80de\u6216\u5176\u5916\u6ccc\u4f53\uff0c\u65e8\u5728\u8c03\u8282ASD\u60a3\u8005\u7684\u514d\u75ab\u53cd\u5e94\u3001\u6539\u5584\u8111\u8840\u6d41\u5e76\u4fc3\u8fdb\u795e\u7ecf\u5143\u4fee\u590d\u3002\u65e9\u671f\u4e34\u5e8a\u8bd5\u9a8c\u8868\u660e\uff0c\u63a5\u53d7\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6cbb\u7597\u7684ASD\u60a3\u8005\u5728\u884c\u4e3a\u3001\u8bed\u8a00\u6280\u80fd\u548c\u793e\u4ea4\u80fd\u529b\u65b9\u9762\u5747\u6709\u4e0d\u540c\u7a0b\u5ea6\u7684\u6539\u5584\uff0c\u4e14\u4e0d\u826f\u53cd\u5e94\u6781\u5c11\u3002\u6b64\u5916\uff0c\u8fd9\u4e9b\u8bd5\u9a8c\u8fd8\u89c2\u5bdf\u5230\u708e\u75c7\u6807\u5fd7\u7269\u6c34\u5e73\u964d\u4f4e\u3001\u8111\u4ee3\u8c22\u6d3b\u52a8\u589e\u5f3a\uff0c\u8fdb\u4e00\u6b65\u652f\u6301\u4e86MSCs\u5728ASD\u6cbb\u7597\u4e2d\u7684\u6f5c\u5728\u4f5c\u7528\u3002<\/p>\n<h3><span class=\"ez-toc-section\" id=\"%E4%B8%B4%E5%BA%8A%E7%A0%94%E7%A9%B6%E7%8E%B0%E7%8A%B6%E5%8F%8A%E4%B8%BB%E8%A6%81%E5%8F%91%E7%8E%B0\"><\/span>\u4e34\u5e8a\u7814\u7a76\u73b0\u72b6\u53ca\u4e3b\u8981\u53d1\u73b0<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u5168\u7403\u5df2\u5b8c\u6210\u591a\u9879\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u7814\u7a76\u4e86\u5e72\u7ec6\u80de\u7597\u6cd5\u5728\u6cbb\u7597\u81ea\u95ed\u75c7\u8c31\u7cfb\u969c\u788d\uff08ASD\uff09\u4e2d\u7684\u5e94\u7528\u3002\u4ee5\u4e0b\u6bb5\u843d\u603b\u7ed3\u4e86\u4e3b\u8981\u4e34\u5e8a\u7814\u7a76\u53ca\u5176\u4e3b\u8981\u7ed3\u679c\uff1a<\/p>\n<p><strong>i) \u5229\u7528\u8110\u5e26\u8840\u5e72\u7ec6\u80de\uff1a<\/strong>2013\u5e74\uff0cLv\u7b49\u4eba\u5f00\u5c55\u4e86\u4e00\u9879\u7814\u7a76\uff0c\u5c06\u8110\u5e26\u8840\u5355\u6838\u7ec6\u80de(CBMNCs)\u4e0e\u8110\u5e26\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u8054\u5408\u6cbb\u7597\uff0c\u5171\u7eb3\u516537\u4f8b\u81ea\u95ed\u75c7\u8c31\u7cfb\u969c\u788d(ASD)\u60a3\u8005\u3002\u7ed3\u679c\u663e\u793a\uff0c\u4e0e\u4ec5\u63a5\u53d7CBMNCs\u6cbb\u7597\u7ec4\u6216\u4ec5\u63a5\u53d7\u5eb7\u590d\u5e72\u9884\u7684\u5bf9\u7167\u7ec4\u76f8\u6bd4\uff0c\u8054\u5408\u6cbb\u7597\u7ec4\u5728\u513f\u7ae5\u5b64\u72ec\u75c7\u8bc4\u5b9a\u91cf\u8868(CARS)\u548c\u5f02\u5e38\u884c\u4e3a\u91cf\u8868(ABC)\u8bc4\u5206\u65b9\u9762\u5747\u6709\u663e\u8457\u6539\u5584\u3002\u7814\u7a76\u671f\u95f4\u672a\u62a5\u544a\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\uff0c\u51f8\u663e\u4e86\u8054\u5408\u6cbb\u7597\u7684\u5b89\u5168\u6027\u548c\u4f18\u8d8a\u7597\u6548<span data-pm-slice=\"1 1 [&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;outer&quot;,&quot;label&quot;:&quot;edit by 135editor&quot;,&quot;data-pm-slice&quot;:&quot;0 0 []&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;paragraph&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;outer&quot;,&quot;label&quot;:&quot;edit by 135editor&quot;,&quot;data-pm-slice&quot;:&quot;0 0 []&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;paragraph&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;outer&quot;,&quot;label&quot;:&quot;edit by 135editor&quot;,&quot;data-pm-slice&quot;:&quot;0 0 []&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;paragraph&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;p&quot;,&quot;attributes&quot;:{},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;node&quot;,{&quot;tagName&quot;:&quot;span&quot;,&quot;attributes&quot;:{&quot;style&quot;:&quot;font-size:15px;&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;}]\">[2]<\/span>The<\/p>\n<\/section>\n<section data-role=\"paragraph\">\n<section><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-21684\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2026\/02\/ScreenShot_2026-02-05_152044_997.png\" alt=\"\" width=\"859\" height=\"323\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2026\/02\/ScreenShot_2026-02-05_152044_997.png 859w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2026\/02\/ScreenShot_2026-02-05_152044_997-300x113.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2026\/02\/ScreenShot_2026-02-05_152044_997-768x289.png 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2026\/02\/ScreenShot_2026-02-05_152044_997-18x7.png 18w\" sizes=\"(max-width: 859px) 100vw, 859px\" \/><\/section>\n<p><strong>ii) \u5229\u7528\u4eba\u7c7b\u80da\u80ce\u5e72\u7ec6\u80de\u7684\u521d\u6b65\u5c1d\u8bd5\uff1a<\/strong>2017\u5e74\uff0cShroff\u62a5\u544a\u4e863\u4f8b\u63a5\u53d7\u4eba\u7c7b\u80da\u80ce\u5e72\u7ec6\u80de\u6cbb\u7597\u7684\u81ea\u95ed\u75c7\u8c31\u7cfb\u969c\u788d (ASD) \u60a3\u8005\u7684\u6cbb\u7597\u7ed3\u679c\u3002\u60a3\u8005\u7684\u8fd0\u52a8\u6280\u80fd\u3001\u8ba4\u77e5\u80fd\u529b\u3001\u793e\u4ea4\u4e92\u52a8\u80fd\u529b\u548c\u611f\u89c9\u654f\u611f\u6027\u5747\u6709\u6240\u6539\u5584\uff0c\u4e14\u672a\u89c2\u5bdf\u5230\u4e0d\u826f\u53cd\u5e94\u3002\u5c3d\u7ba1\u6837\u672c\u91cf\u8f83\u5c0f\uff0c\u4f46\u8fd9\u9879\u7814\u7a76\u51f8\u663e\u4e86\u5e72\u7ec6\u80de\u7597\u6cd5\u5728\u7f13\u89e3<span class=\"\">ASD\u6838\u5fc3\u75c7\u72b6<\/span>\u65b9\u9762\u7684\u6f5c\u529b<span data-pm-slice=\"1 1 [&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;outer&quot;,&quot;label&quot;:&quot;edit by 135editor&quot;,&quot;data-pm-slice&quot;:&quot;0 0 []&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;paragraph&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;outer&quot;,&quot;label&quot;:&quot;edit by 135editor&quot;,&quot;data-pm-slice&quot;:&quot;0 0 []&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;paragraph&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;outer&quot;,&quot;label&quot;:&quot;edit by 135editor&quot;,&quot;data-pm-slice&quot;:&quot;0 0 []&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;paragraph&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;p&quot;,&quot;attributes&quot;:{},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;node&quot;,{&quot;tagName&quot;:&quot;span&quot;,&quot;attributes&quot;:{&quot;style&quot;:&quot;font-size:15px;&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;}]\">[3]<\/span>The<\/p>\n<\/section>\n<section data-role=\"paragraph\">\n<section>\n<div id=\"attachment_21683\" style=\"width: 750px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-21683\" class=\"wp-image-21683 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2026\/02\/ScreenShot_2026-02-05_152151_838.png\" alt=\"\" width=\"740\" height=\"332\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2026\/02\/ScreenShot_2026-02-05_152151_838.png 740w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2026\/02\/ScreenShot_2026-02-05_152151_838-300x135.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2026\/02\/ScreenShot_2026-02-05_152151_838-18x8.png 18w\" sizes=\"(max-width: 740px) 100vw, 740px\" \/><p id=\"caption-attachment-21683\" class=\"wp-caption-text\">\u4eba\u7c7b\u80da\u80ce\u5e72\u7ec6\u80de\u6cbb\u7597\u81ea\u95ed\u75c7\uff1a\u75c5\u4f8b\u7cfb\u5217\u7814\u7a76<\/p><\/div>\n<\/section>\n<\/section>\n<section data-role=\"paragraph\"><strong>iii) \u81ea\u4f53\u8110\u5e26\u8840\u7597\u6cd5\u7684\u6f5c\u529b\uff1a<\/strong>2018\u5e74\uff0cChez\u7b49\u4eba\u5f00\u5c55\u4e86\u4e00\u9879\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u4ea4\u53c9\u7814\u7a76\uff0c\u7eb3\u516529\u540d2\u81f36\u5c81\u7684\u81ea\u95ed\u75c7\u8c31\u7cfb\u969c\u788d(ASD)\u513f\u7ae5\uff0c\u8bc4\u4f30\u81ea\u4f53\u8110\u5e26\u8840\u8f93\u6ce8\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002\u5c3d\u7ba1\u6cbb\u7597\u5e76\u672a\u663e\u8457\u6539\u5584\u4e3b\u8981\u7ec8\u70b9\uff0c\u4f46\u90e8\u5206\u53d7\u8bd5\u8005\u8868\u73b0\u51fa\u793e\u4ea4\u548c\u8bed\u8a00\u6280\u80fd\u6539\u5584\u7684\u8d8b\u52bf\u3002\u672a\u53d1\u751f\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\uff0c\u63d0\u793a\u5e72\u7ec6\u80de\u7597\u6cd5\u53ef\u80fd\u5177\u6709\u6539\u5584\u793e\u4ea4\u529f\u80fd\u7684\u6f5c\u529b<span data-pm-slice=\"1 1 [&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;outer&quot;,&quot;label&quot;:&quot;edit by 135editor&quot;,&quot;data-pm-slice&quot;:&quot;0 0 []&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;paragraph&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;outer&quot;,&quot;label&quot;:&quot;edit by 135editor&quot;,&quot;data-pm-slice&quot;:&quot;0 0 []&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;paragraph&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;outer&quot;,&quot;label&quot;:&quot;edit by 135editor&quot;,&quot;data-pm-slice&quot;:&quot;0 0 []&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;paragraph&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;p&quot;,&quot;attributes&quot;:{},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;node&quot;,{&quot;tagName&quot;:&quot;span&quot;,&quot;attributes&quot;:{&quot;style&quot;:&quot;font-size:15px;&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;}]\">[4]<\/span>The<\/section>\n<section data-role=\"paragraph\">\n<section>\n<div id=\"attachment_21682\" style=\"width: 656px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-21682\" class=\"wp-image-21682 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2026\/02\/ScreenShot_2026-02-05_152222_085.png\" alt=\"\" width=\"646\" height=\"328\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2026\/02\/ScreenShot_2026-02-05_152222_085.png 646w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2026\/02\/ScreenShot_2026-02-05_152222_085-300x152.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2026\/02\/ScreenShot_2026-02-05_152222_085-18x9.png 18w\" sizes=\"(max-width: 646px) 100vw, 646px\" \/><p id=\"caption-attachment-21682\" class=\"wp-caption-text\">\u4e00\u9879\u5b89\u6170\u5242\u5bf9\u7167\u4ea4\u53c9\u7814\u7a76\u7684\u5b89\u5168\u6027\u548c\u89c2\u5bdf\u7ed3\u679c\uff0c\u65e8\u5728\u8bc4\u4f30\u81ea\u4f53\u8110\u5e26\u8840\u5e72\u7ec6\u80de\u5728\u6539\u5584\u81ea\u95ed\u75c7\u513f\u7ae5\u75c7\u72b6\u65b9\u9762\u7684\u5e94\u7528<\/p><\/div>\n<\/section>\n<\/section>\n<section data-role=\"paragraph\"><strong>\u56db\uff09\u8111\u7f51\u7edc\u8fde\u63a5\u7684\u53d8\u5316\uff1a<\/strong>Simhal\u7b49\u4eba\u5229\u7528\u5f25\u6563\u5f20\u91cf\u6210\u50cf\u6280\u672f\u8bc4\u4f30\u4e86\u8110\u5e26\u8840\u5e72\u7ec6\u80de\u7597\u6cd5\u5bf9\u81ea\u95ed\u75c7\u8c31\u7cfb\u969c\u788d(ASD)\u60a3\u8005\u767d\u8d28\u7f51\u7edc\u7684\u5f71\u54cd\u3002\u4ed6\u4eec\u7684\u7814\u7a76\u8868\u660e\uff0c\u6cbb\u7597\u540e\u767d\u8d28\u7f51\u7edc\u7684\u7a33\u5065\u6027\u663e\u8457\u589e\u5f3a\uff0c\u5c24\u5176\u662f\u5728\u4e0e\u793e\u4ea4\u548c\u6c9f\u901a\u529f\u80fd\u76f8\u5173\u7684\u533a\u57df\u3002\u8fd9\u4e9b\u53d1\u73b0\u53ef\u80fd\u4e0e\u5e72\u7ec6\u80de\u8c03\u8282\u795e\u7ecf\u708e\u75c7\u548c\u4fc3\u8fdb\u795e\u7ecf\u53ef\u5851\u6027\u7684\u80fd\u529b\u6709\u5173<span data-pm-slice=\"1 1 [&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;outer&quot;,&quot;label&quot;:&quot;edit by 135editor&quot;,&quot;data-pm-slice&quot;:&quot;0 0 []&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;paragraph&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;outer&quot;,&quot;label&quot;:&quot;edit by 135editor&quot;,&quot;data-pm-slice&quot;:&quot;0 0 []&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;paragraph&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;outer&quot;,&quot;label&quot;:&quot;edit by 135editor&quot;,&quot;data-pm-slice&quot;:&quot;0 0 []&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;paragraph&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;p&quot;,&quot;attributes&quot;:{},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;node&quot;,{&quot;tagName&quot;:&quot;span&quot;,&quot;attributes&quot;:{&quot;style&quot;:&quot;font-size:15px;&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;}]\">[5]<\/span>The<\/section>\n<section data-role=\"paragraph\">\n<section><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-21681 aligncenter\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2026\/02\/ScreenShot_2026-02-05_152419_071.png\" alt=\"\" width=\"721\" height=\"444\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2026\/02\/ScreenShot_2026-02-05_152419_071.png 721w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2026\/02\/ScreenShot_2026-02-05_152419_071-300x185.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2026\/02\/ScreenShot_2026-02-05_152419_071-18x12.png 18w\" sizes=\"(max-width: 721px) 100vw, 721px\" \/><\/section>\n<p><strong>\u4e94\uff09\u5e72\u7ec6\u80de\u7ed3\u5408\u884c\u4e3a\u5e72\u9884\uff1a<\/strong>Thanh\u7b49\u4eba\u5728\u8d8a\u5357\u5f00\u5c55\u4e86\u4e00\u9879\u5f00\u653e\u6807\u7b7e\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u7eb3\u5165\u4e8630\u540d3\u81f37\u5c81\u7684\u81ea\u95ed\u75c7\u8c31\u7cfb\u969c\u788d (ASD) \u513f\u7ae5\u3002\u5e72\u9884\u63aa\u65bd\u7ed3\u5408\u4e86\u81ea\u4f53\u9aa8\u9ad3\u5355\u6838\u7ec6\u80de\u79fb\u690d\u548c\u65e9\u671f\u884c\u4e3a\u5e72\u9884 (ESDM)<span data-pm-slice=\"1 1 [&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;outer&quot;,&quot;label&quot;:&quot;edit by 135editor&quot;,&quot;data-pm-slice&quot;:&quot;0 0 []&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;paragraph&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;outer&quot;,&quot;label&quot;:&quot;edit by 135editor&quot;,&quot;data-pm-slice&quot;:&quot;0 0 []&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;paragraph&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;outer&quot;,&quot;label&quot;:&quot;edit by 135editor&quot;,&quot;data-pm-slice&quot;:&quot;0 0 []&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;section&quot;,&quot;attributes&quot;:{&quot;data-role&quot;:&quot;paragraph&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;para&quot;,{&quot;tagName&quot;:&quot;p&quot;,&quot;attributes&quot;:{},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;},&quot;node&quot;,{&quot;tagName&quot;:&quot;span&quot;,&quot;attributes&quot;:{&quot;style&quot;:&quot;font-size:15px;&quot;},&quot;namespaceURI&quot;:&quot;http:\/\/www.w3.org\/1999\/xhtml&quot;}]\">[6]<\/span>The<\/p>\n<\/section>\n<section data-role=\"paragraph\">\n<section>\n<div id=\"attachment_21680\" style=\"width: 948px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-21680\" class=\"wp-image-21680 size-full\" src=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2026\/02\/ScreenShot_2026-02-05_152519_694.png\" alt=\"\" width=\"938\" height=\"596\" title=\"\" srcset=\"https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2026\/02\/ScreenShot_2026-02-05_152519_694.png 938w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2026\/02\/ScreenShot_2026-02-05_152519_694-300x191.png 300w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2026\/02\/ScreenShot_2026-02-05_152519_694-768x488.png 768w, https:\/\/www.hjtdsm.cn\/wp-content\/uploads\/2026\/02\/ScreenShot_2026-02-05_152519_694-18x12.png 18w\" sizes=\"(max-width: 938px) 100vw, 938px\" \/><p id=\"caption-attachment-21680\" class=\"wp-caption-text\">\u9aa8\u9ad3\u5355\u6838\u7ec6\u80de\u79fb\u690d\u8054\u5408\u5e72\u9884\u6559\u80b2\u6cbb\u7597\u81ea\u95ed\u75c7\u8c31\u7cfb\u969c\u788d\u7684\u7597\u6548<\/p><\/div>\n<\/section>\n<\/section>\n<section data-role=\"paragraph\">\u7ed3\u679c\u663e\u793a\uff0c\u513f\u7ae5\u81ea\u95ed\u75c7\u8bc4\u5b9a\u91cf\u8868 (CARS) \u4e2d\u4f4d\u6570\u8bc4\u5206\u4ece50\u5206\u964d\u81f346.5\u5206 (P&lt;0.05)\uff0c\u6587\u5170\u9002\u5e94\u6027\u884c\u4e3a\u91cf\u8868 (Vineland Adaptive Behavior Scale) \u8bc4\u5206\u4ece53.5\u5206\u5347\u81f360.5\u5206\uff0c\u8868\u660e\u513f\u7ae5\u7684\u793e\u4ea4\u4e92\u52a8\u3001\u8bed\u8a00\u80fd\u529b\u548c\u65e5\u5e38\u751f\u6d3b\u6280\u80fd\u5747\u5f97\u5230\u663e\u8457\u6539\u5584\uff0c\u4e14\u672a\u62a5\u544a\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\u3002\u4e0a\u8ff0\u4e34\u5e8a\u7814\u7a76\u5171\u540c\u8868\u660e\uff0c\u57fa\u4e8e\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u53ca\u5176\u5916\u6ccc\u4f53\u7684\u7597\u6cd5\u6709\u671b\u6539\u5584 ASD \u60a3\u8005\u7684\u793e\u4ea4\u6c9f\u901a\u3001\u8bed\u8a00\u6280\u80fd\u3001\u884c\u4e3a\u6311\u6218\u548c\u8ba4\u77e5\u80fd\u529b\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u8054\u5408\u6cbb\u7597\u7684\u6709\u6548\u6027\u53ef\u80fd\u4e0e\u5176\u591a\u9776\u70b9\u4f5c\u7528\u673a\u5236\u6709\u5173\u3002\u5927\u591a\u6570\u7814\u7a76\u672a\u62a5\u544a\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\uff0c\u8868\u660e\u5176\u603b\u4f53\u5b89\u5168\u6027\u826f\u597d\u3002<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%E5%B9%B2%E7%BB%86%E8%83%9E%E5%A4%96%E6%B3%8C%E4%BD%93%E6%B2%BB%E7%96%97%E8%87%AA%E9%97%AD%E7%97%87%E7%9A%84%E6%A0%B8%E5%BF%83%E4%BC%98%E5%8A%BF%E5%92%8C%E5%A4%9A%E6%96%B9%E9%9D%A2%E6%9C%BA%E5%88%B6\"><\/span><strong>\u5e72\u7ec6\u80de\u5916\u6ccc\u4f53\u6cbb\u7597\u81ea\u95ed\u75c7\u7684\u6838\u5fc3\u4f18\u52bf\u548c\u591a\u65b9\u9762\u673a\u5236<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>\u7531\u4e8e\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u5177\u6709\u663e\u8457\u7684\u514d\u75ab\u8c03\u8282\u7279\u6027\u3001\u7ec4\u7ec7\u4fee\u590d\u6f5c\u80fd\u548c\u826f\u597d\u7684\u5b89\u5168\u6027\uff0c\u8fd1\u5e74\u6765\u5907\u53d7\u5173\u6ce8\uff0c\u5e76\u9010\u6e10\u6210\u4e3a\u5e72\u7ec6\u80de\u7597\u6cd5\u7684\u91cd\u8981\u7814\u7a76\u65b9\u5411\u3002\u968f\u7740MSCs\u7814\u7a76\u7684\u6df1\u5165\uff0c\u5176\u5206\u6ccc\u7684\u5916\u6ccc\u4f53\u5df2\u88ab\u786e\u5b9a\u4e3a\u4e00\u79cd\u5173\u952e\u7684\u529f\u80fd\u6027\u4ecb\u8d28\uff0c\u6709\u671b\u5728ASD\u7684\u5e72\u9884\u4e2d\u53d1\u6325\u6f5c\u5728\u4f5c\u7528\u3002\u76ee\u524d\uff0c\u5927\u591a\u6570\u5173\u4e8eMSCs \u548cMSC-Exos\u7684\u4e34\u5e8a\u7814\u7a76\u4ecd\u5904\u4e8eI\/II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u9636\u6bb5\u3002<\/p>\n<p>\u65e9\u671f\u6570\u636e\u663e\u793a\uff0c\u63a5\u53d7\u8fd9\u4e9b\u7597\u6cd5\u6cbb\u7597\u7684ASD\u60a3\u8005\u7684\u793e\u4ea4\u4e92\u52a8\u548c\u8bed\u8a00\u80fd\u529b\u6709\u6240\u6539\u5584\uff0c\u708e\u75c7\u6807\u5fd7\u7269\u6c34\u5e73\u4e5f\u6709\u6240\u964d\u4f4e\u3002\u4e0b\u6587\u5c06\u63a2\u8ba8\u5176\u4e34\u5e8a\u8f6c\u5316\u8fc7\u7a0b\u4e2d\u7684\u6838\u5fc3\u4f18\u52bf\u4e0e\u591a\u65b9\u9762\u673a\u5236\uff1a<\/p>\n<h3><span class=\"ez-toc-section\" id=\"%E6%A0%B8%E5%BF%83%E4%BC%98%E5%8A%BF%E5%92%8C%E5%A4%9A%E6%96%B9%E9%9D%A2%E6%9C%BA%E5%88%B6\"><\/span>\u6838\u5fc3\u4f18\u52bf\u548c\u591a\u65b9\u9762\u673a\u5236<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><strong>i) \u591a\u529f\u80fd\u6027\uff1a\u514d\u75ab\u8c03\u8282\u4e0e\u795e\u7ecf\u4fdd\u62a4<\/strong><\/p>\n<p>\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u53ca\u5176\u5916\u6ccc\u4f53\u7684\u514d\u75ab\u8c03\u8282\u548c\u795e\u7ecf\u4fdd\u62a4\u7279\u6027\u4f7f\u5176\u6210\u4e3a\u6cbb\u7597ASD\u591a\u79cd\u75c5\u7406\u673a\u5236\u7684\u7406\u60f3\u9009\u62e9\u3002\u7814\u7a76\u8868\u660e\uff0cMSC-Exos\u80fd\u591f\u8c03\u8282T\u7ec6\u80de\u548cB\u7ec6\u80de\u7684\u6d3b\u5316\uff0c\u8bf1\u5bfc\u514d\u75ab\u8010\u53d7\uff0c\u5e76\u6291\u5236\u708e\u75c7\u7ec6\u80de\u56e0\u5b50\u7684\u5206\u6ccc\uff0c\u4ece\u800c\u6539\u5584\u795e\u7ecf\u708e\u75c7\u72b6\u6001\u3002<\/p>\n<p>\u6b64\u5916\uff0cMSC-Exos\u4e2d\u7684\u751f\u957f\u56e0\u5b50\u3001miRNA\u548c\u5176\u4ed6\u751f\u7269\u6d3b\u6027\u7269\u8d28\u8fd8\u80fd\u4fc3\u8fdb\u795e\u7ecf\u5143\u5b58\u6d3b\u548c\u7a81\u89e6\u53ef\u5851\u6027\u3002\u7531\u4e8e\u5176\u5206\u5316\u6f5c\u80fd\uff0cMSCs\u53ca\u5176\u5916\u6ccc\u4f53\u4e5f\u53ef\u4f5c\u4e3a\u795e\u7ecf\u4fee\u590d\u7684\u5de5\u5177\uff0c\u4e3a\u6cbb\u7597ASD\u76f8\u5173\u7684\u795e\u7ecf\u53d1\u80b2\u5f02\u5e38\u63d0\u4f9b\u6f5c\u5728\u4ef7\u503c\u3002<\/p>\n<p><strong>ii) \u514d\u75ab\u539f\u6027\u4f4e\uff0c\u5b89\u5168\u6027\u826f\u597d<\/strong><\/p>\n<p>\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u5728\u540c\u79cd\u5f02\u4f53\u79fb\u690d\u4e2d\u8868\u73b0\u51fa\u76f8\u5bf9\u8f83\u4f4e\u7684\u514d\u75ab\u539f\u6027\u3002\u5176\u5916\u6ccc\u4f53\u7f3a\u4e4f\u5b8c\u6574\u7684\u7ec6\u80de\u8868\u9762\u6297\u539f\u8868\u8fbe\uff0c\u4e14\u4e0d\u542b\u7ec6\u80de\u6838\u6216\u5b8c\u6574\u7684\u57fa\u56e0\u7ec4\uff0c\u8fdb\u4e00\u6b65\u964d\u4f4e\u4e86\u514d\u75ab\u6392\u65a5\u548c\u80bf\u7624\u53d1\u751f\u7684\u98ce\u9669\u3002\u56e0\u6b64\uff0cMSC-Exos\u79fb\u690d\u65e0\u9700\u50cf\u540c\u79cd\u5f02\u4f53MSCs\u90a3\u6837\u4e25\u683c\u5339\u914d\u4f9b\u4f53\u548c\u53d7\u4f53\uff0c\u4ece\u800c\u51cf\u5c11\u4e86\u6f5c\u5728\u7684\u5e76\u53d1\u75c7\u548c\u4f26\u7406\u95ee\u9898\u3002<\/p>\n<p><strong>iii) \u9776\u5411\u6cbb\u7597\u4e0e\u4e2a\u6027\u5316\u6cbb\u7597<\/strong><\/p>\n<p>\u5916\u6ccc\u4f53\u53ef\u901a\u8fc7\u53d7\u4f53\u4ecb\u5bfc\u7684\u5185\u541e\u4f5c\u7528\u6216\u819c\u878d\u5408\u8fdb\u5165\u9776\u7ec6\u80de\uff0c\u9012\u9001\u591a\u79cd\u6d3b\u6027\u5206\u5b50\uff0c\u4ece\u800c\u5f71\u54cd\u7ec6\u80de\u589e\u6b96\u3001\u5206\u5316\u3001\u51cb\u4ea1\u548c\u514d\u75ab\u53cd\u5e94\u3002\u7531\u4e8e\u5176\u7eb3\u7c73\u7ea7\u5c3a\u5bf8\u548c\u8102\u8d28\u53cc\u5c42\u7ed3\u6784\uff0c\u5916\u6ccc\u4f53\u5177\u6709\u8f83\u9ad8\u7684\u8de8\u819c\u9012\u9001\u6548\u7387\uff0c\u4e14\u7814\u7a76\u8868\u660e\u5176\u80fd\u591f\u7a7f\u8fc7\u8840\u8111\u5c4f\u969c\u3002<\/p>\n<p>\u9274\u4e8eASD\u7684\u53d1\u75c5\u673a\u5236\u6d89\u53ca\u5f02\u5e38\u7684\u795e\u7ecf\u7f51\u7edc\u548c\u4e2d\u67a2\u795e\u7ecf\u708e\u75c7\uff0c\u80fd\u591f\u7a7f\u900f\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u7684MSC-Exos\u53ef\u80fd\u6709\u52a9\u4e8e\u91cd\u5851\u8111\u5fae\u73af\u5883\u5e76\u6539\u5584\u6cbb\u7597\u6548\u679c\u3002\u6b64\u5916\uff0c\u57fa\u4e8e\u4e2a\u4f53\u60a3\u8005\u7684\u75c5\u7406\u7279\u5f81\u5bf9MSCs\u8fdb\u884c\u5de5\u7a0b\u6539\u9020\u6216\u4fee\u9970\u5916\u6ccc\u4f53\u8f7d\u8377\uff0c\u53ef\u80fd\u5b9e\u73b0\u66f4\u7cbe\u51c6\u3001\u4e2a\u6027\u5316\u7684\u6cbb\u7597\u3002<\/p>\n<p><strong>iv) \u5927\u89c4\u6a21\u751f\u4ea7\u3001\u8fd0\u8f93\u4e0e\u50a8\u5b58<\/strong><\/p>\n<p>\u5728\u7279\u5b9a\u7684\u57f9\u517b\u6761\u4ef6\u4e0b\uff0c\u5916\u6ccc\u4f53\u53ef\u4ee5\u5927\u91cf\u751f\u4ea7\u548c\u7eaf\u5316\u3002\u4e0e\u9700\u8981\u8db3\u591f\u6570\u91cf\u4e14\u5177\u6709\u9ad8\u6d3b\u6027\u3001\u7279\u6027\u660e\u786e\u7684\u6d3b\u7ec6\u80de\u76f8\u6bd4\uff0c\u5916\u6ccc\u4f53\u66f4\u5bb9\u6613\u6807\u51c6\u5316\u548c\u5927\u89c4\u6a21\u751f\u4ea7\uff0c\u4ece\u800c\u4f7f\u5176\u4e34\u5e8a\u5e94\u7528\u66f4\u5177\u53ef\u884c\u6027\u3002\u6b64\u5916\uff0c\u5728\u9002\u5f53\u6761\u4ef6\u4e0b\uff0c\u5916\u6ccc\u4f53\u53ef\u4ee5\u957f\u671f\u50a8\u5b58\u5e76\u4fdd\u6301\u5176\u751f\u7269\u6d3b\u6027\uff0c\u907f\u514d\u4e86\u6d3b\u4f53 MSCs \u6240\u9762\u4e34\u7684\u8bb8\u591a\u7a33\u5b9a\u6027\u6311\u6218\uff0c\u6709\u5229\u4e8e\u5927\u89c4\u6a21\u751f\u4ea7\u3001\u4e34\u5e8a\u50a8\u5907\u548c\u66f4\u5e7f\u6cdb\u7684\u5730\u57df\u5206\u53d1\u3002<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%E7%BB%93%E8%AE%BA\"><\/span><strong>reach a verdict<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u53ca\u5176\u5916\u6ccc\u4f53\u5728\u81ea\u95ed\u75c7\u8c31\u7cfb\u969c\u788d\u7684\u6cbb\u7597\u4e2d\u5c55\u73b0\u51fa\u5de8\u5927\u7684\u6f5c\u529b\u3002\u5b83\u4eec\u53ef\u901a\u8fc7\u514d\u75ab\u8c03\u8282\u548c\u795e\u7ecf\u4fdd\u62a4\u4f5c\u7528\u51cf\u8f7b\u795e\u7ecf\u708e\u75c7\u3001\u589e\u5f3a\u7a81\u89e6\u53ef\u5851\u6027\u5e76\u4fc3\u8fdb\u795e\u7ecf\u7f51\u7edc\u4fee\u590d\u3002MSC-Exos\u5728ASD\u6cbb\u7597\u65b9\u9762\u5177\u6709\u591a\u65b9\u9762\u6cbb\u7597\u673a\u5236\u3001\u4f4e\u514d\u75ab\u539f\u6027\u548c\u6613\u4e8e\u89c4\u6a21\u5316\u751f\u4ea7\u7b49\u663e\u8457\u4f18\u52bf\u3002<\/p>\n<p>\u7136\u800c\uff0c\u5728MSC-Exos\u80fd\u591f\u5e7f\u6cdb\u5e94\u7528\u4e8eASD\u6cbb\u7597\u4e4b\u524d\uff0c\u4ecd\u9700\u514b\u670d\u4e00\u4e9b\u5173\u952e\u969c\u788d\uff0c\u5305\u62ec\u751f\u4ea7\u6d41\u7a0b\u6807\u51c6\u5316\u3001\u8d28\u91cf\u63a7\u5236\u3001\u4f5c\u7528\u673a\u5236\u6df1\u5165\u9610\u660e\u3001\u957f\u671f\u5b89\u5168\u6027\u8bc4\u4f30\u4ee5\u53ca\u4e2a\u4f53\u5316\u5e94\u7528\u7b56\u7565\u7b49\u3002\u901a\u8fc7\u591a\u5b66\u79d1\u5408\u4f5c\u4e0e\u8fdb\u4e00\u6b65\u7814\u7a76\u5e94\u5bf9\u8fd9\u4e9b\u6311\u6218\uff0c\u5c06\u4e3a\u5f00\u53d1\u66f4\u7cbe\u51c6\u3001\u5b89\u5168\u548c\u6709\u6548\u7684\u5e72\u9884\u63aa\u65bd\u94fa\u5e73\u9053\u8def\u3002<\/p>\n<p>\u5916\u6ccc\u4f53\u5177\u6709\u4f4e\u514d\u75ab\u539f\u6027\u3001\u80fd\u591f\u7a7f\u8d8a\u8840\u8111\u5c4f\u969c\u4ee5\u53ca\u9ad8\u6548\u9012\u9001\u751f\u7269\u6d3b\u6027\u5206\u5b50\u7b49\u4f18\u70b9\uff0c\u662f\u6cbb\u7597ASD\u548c\u5176\u4ed6\u795e\u7ecf\u53d1\u80b2\u969c\u788d\u7684\u7406\u60f3\u5019\u9009\u7b56\u7565\u3002\u7136\u800c\uff0c\u76ee\u524d\u4ecd\u5b58\u5728\u8bf8\u591a\u5173\u952e\u6311\u6218\uff0c\u5305\u62ec\u5927\u89c4\u6a21\u751f\u4ea7\u3001\u8d28\u91cf\u63a7\u5236\u4ee5\u53ca\u6f5c\u5728\u673a\u5236\u9610\u660e\u7b49\u95ee\u9898\u3002\u6b64\u5916\uff0c\u8fd8\u9700\u8981\u5728\u4e25\u683c\u7684\u76d1\u7ba1\u548c\u4f26\u7406\u6846\u67b6\u4e0b\u5f00\u5c55\u4e25\u8c28\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u4ee5\u9a8c\u8bc1MSC-Exos\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002<\/p>\n<p>\u56e0\u6b64\uff0c\u4e9f\u9700\u9610\u660e\u5176\u4f5c\u7528\u673a\u5236\uff0c\u5236\u5b9a\u6807\u51c6\u5316\u7684\u751f\u4ea7\u548c\u8d28\u91cf\u63a7\u5236\u65b9\u6848\uff0c\u5e76\u4f18\u5316\u5176\u957f\u671f\u5b89\u5168\u6027\u548c\u4e2a\u4f53\u5316\u6cbb\u7597\u7b56\u7565\u3002\u968f\u7740\u9ad8\u901a\u91cf\u7ec4\u5b66\u6280\u672f\u3001\u8de8\u5b66\u79d1\u5408\u4f5c\u548c\u6301\u7eed\u521b\u65b0\u7684\u878d\u5408\uff0cMSC-Exos\u6709\u671b\u5728\u57fa\u7840\u7814\u7a76\u548c\u4e34\u5e8a\u5e94\u7528\u65b9\u9762\u53d6\u5f97\u8fdb\u5c55\uff0c\u4e3aASD\u7684\u6cbb\u7597\u63d0\u4f9b\u66f4\u9ad8\u7684\u7cbe\u51c6\u5ea6\u548c\u66f4\u5e7f\u6cdb\u7684\u6cbb\u7597\u6f5c\u529b\u3002\u6700\u7ec8\uff0c\u53ea\u6709\u514b\u670d\u5173\u952e\u7684\u79d1\u5b66\u4e0e\u6280\u672f\u969c\u788d\uff0cMSC-Exos\u624d\u80fd\u6210\u4e3a\u4e2a\u4f53\u5316\u5e72\u9884\u7684\u53ef\u884c\u7b56\u7565\u3002<\/p>\n<h3><span class=\"ez-toc-section\" id=\"%E6%9C%AA%E6%9D%A5%E6%8A%80%E6%9C%AF%E5%88%9B%E6%96%B0%E6%96%B9%E5%90%91\"><\/span>\u672a\u6765\u6280\u672f\u521b\u65b0\u65b9\u5411<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u672a\u6765\u7814\u7a76\u5c06\u901a\u8fc7\u591a\u7ef4\u5ea6\u7684\u6280\u672f\u521b\u65b0\u6765\u63d0\u9ad8\u7597\u6548\u548c\u4e34\u5e8a\u8f6c\u5316\u6548\u7387\u3002\u4f8b\u5982\uff0c\u5f00\u53d1\u78c1\u6027\u7eb3\u7c73\u9897\u7c92\u3001\u6c34\u51dd\u80f6\u7b49\u9012\u9001\u5e73\u53f0\u4ee5\u589e\u5f3a\u5916\u6ccc\u4f53\u5728\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u4e2d\u7684\u9776\u5411\u6027\u548c\u7a33\u5b9a\u6027\uff1b\u5229\u7528\u5316\u5b66\u4fee\u9970\u548c\u57fa\u56e0\u5de5\u7a0b\u6280\u672f\u5bf9 MSC-Exos \u8fdb\u884c\u5de5\u7a0b\u5316\u6539\u9020\uff0c\u8fc7\u8868\u8fbe\u795e\u7ecf\u8425\u517b\u56e0\u5b50\u6216\u6297\u708e\u5206\u5b50\uff0c\u4ece\u800c\u63d0\u5347\u5176\u795e\u7ecf\u4fdd\u62a4\u548c\u514d\u75ab\u8c03\u8282\u80fd\u529b\u3002<\/p>\n<p>\u540c\u65f6\uff0c\u7ed3\u5408\u9ad8\u901a\u91cf\u7ec4\u5b66\u6280\u672f\uff08\u5982\u57fa\u56e0\u7ec4\u5b66\u3001\u86cb\u767d\u8d28\u7ec4\u5b66\uff09\u63ed\u793a\u5916\u6ccc\u4f53\u8c03\u63a7\u795e\u7ecf\u4fee\u590d\u7684\u5173\u952e\u5206\u5b50\u7f51\u7edc\uff0c\u4e3a\u4e2a\u6027\u5316\u533b\u7597\u2014\u2014\u5373\u5b9a\u5236\u5916\u6ccc\u4f53\u5236\u5242\u548c\u4e2a\u4f53\u5316\u6cbb\u7597\u65b9\u6848\u2014\u2014\u5960\u5b9a\u57fa\u7840\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<blockquote><p>References:<\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">[1] <\/span><\/span><span data-pm-slice=\"0 0 []\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">Sun Z, Amjad N, Muhammad M \u548c Li Z: &lt;p&gt;\u5229\u7528 MSC \u884d\u751f\u7684\u5916\u6ccc\u4f53\u8c03\u8282 ASD \u7684\u75c5\u7406\u751f\u7406\u5b66\uff1a\u6700\u65b0\u8fdb\u5c55\u548c\u6cbb\u7597\u610f\u4e49\uff08\u7efc\u8ff0\uff09&lt;\/p&gt;\u3002Int J Mol Med 57: 60, 2026\u3002<\/span><\/span><\/span><\/p>\n<p><span data-pm-slice=\"0 0 []\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">[2] Lv YT, Zhang Y, Liu M, Qiuwaxi JN, Ashwood P, Cho SC, Huan Y, Ge RC, Chen XW, Wang ZJ, et al: \u4eba\u8110\u5e26\u8840\u5355\u6838\u7ec6\u80de\u548c\u8110\u5e26\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u79fb\u690d\u6cbb\u7597\u81ea\u95ed\u75c7\u3002J Transl Med. 11:1962013\u3002\u67e5\u770b\u6587\u7ae0\uff1aGoogle Scholar\uff1aPubMed\/NCBI<\/span><\/span><\/span><\/p>\n<p><span data-pm-slice=\"0 0 []\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">[3] <\/span><\/span><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">Shroff G\uff1a\u4eba\u7c7b\u80da\u80ce\u5e72\u7ec6\u80de\u5728\u81ea\u95ed\u75c7\u6cbb\u7597\u4e2d\u7684\u5e94\u7528\uff1a\u75c5\u4f8b\u7cfb\u5217\u7814\u7a76\u3002Innov Clin Neurosci. 14:12\u201316. 2017. PubMed\/NCBI<\/span><\/span><\/span><\/p>\n<p><span data-pm-slice=\"0 0 []\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">[4] <\/span><\/span><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">Chez M\u3001Lepage C\u3001Parise C\u3001Dang-Chu A\u3001Hankins A \u548c Carroll M\uff1a\u4e00\u9879\u5b89\u6170\u5242\u5bf9\u7167\u4ea4\u53c9\u7814\u7a76\u7684\u5b89\u5168\u6027\u548c\u89c2\u5bdf\u7ed3\u679c\uff0c\u8be5\u7814\u7a76\u65e8\u5728\u8bc4\u4f30\u81ea\u4f53\u8110\u5e26\u8840\u5e72\u7ec6\u80de\u5728\u6539\u5584\u81ea\u95ed\u75c7\u513f\u7ae5\u75c7\u72b6\u65b9\u9762\u7684\u5e94\u7528\u3002\u300a\u5e72\u7ec6\u80de\u8f6c\u5316\u533b\u5b66\u300b7:333\u2013341\u30022018\u3002\u67e5\u770b\u6587\u7ae0\uff1aGoogle Scholar\uff1aPubMed\/NCBI<\/span><\/span><\/span><\/p>\n<p><span data-pm-slice=\"0 0 []\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">[5] <\/span><\/span><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">Simhal AK, Carpenter KLH, Nadeem S, Kurtzberg J, Song A, Tannenbaum A, Sapiro G \u548c Dawson G\uff1a\u5229\u7528\u91cc\u5947\u66f2\u7387\u6d4b\u91cf\u81ea\u95ed\u75c7\u8c31\u7cfb\u969c\u788d\u60a3\u8005\u8111\u7f51\u7edc\u7684\u7a33\u5065\u6027\u3002Sci Rep. 10:108192020\u3002\u67e5\u770b\u6587\u7ae0\uff1aGoogle Scholar\uff1aPubMed\/NCBI<\/span><\/span><\/span><\/p>\n<p><span data-pm-slice=\"0 0 []\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">[6] <\/span><\/span><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">Thanh LN, Nguyen HP, Ngo MD, Bui VA, Dam PTM, Bui HTP, Ngo DV, Tran KT, Dang TTT, Duong BD \u7b49\uff1a\u9aa8\u9ad3\u5355\u6838\u7ec6\u80de\u79fb\u690d\u8054\u5408\u5e72\u9884\u6559\u80b2\u6cbb\u7597\u81ea\u95ed\u75c7\u8c31\u7cfb\u969c\u788d\u7684\u7597\u6548\u3002\u5e72\u7ec6\u80de\u8f6c\u5316\u533b\u5b66\u300210:14\u201326\u30022021\u3002\u67e5\u770b\u6587\u7ae0\uff1aGoogle Scholar<\/span><\/span><\/span><\/p>\n<p>Disclaimer: This article is intended only to disseminate scientific knowledge and share industry perspectives, and does not constitute any clinical diagnostic advice! The information published by Hangi Stem Cells is not a substitute for the professional advice of a physician or pharmacist. If you have any questions about copyright or other issues, please feel free to contact me.<\/p><\/blockquote>","protected":false},"excerpt":{"rendered":"<p>\u81ea\u95ed\u75c7\u8c31\u7cfb\u969c\u788d\uff08ASD\uff09\u662f\u4e00\u79cd\u590d\u6742\u7684\u795e\u7ecf\u53d1\u80b2\u969c\u788d\uff0c\u5176\u7279\u5f81\u8868\u73b0\u4e3a\u663e\u8457\u7684\u9057\u4f20\u5f02\u8d28\u6027\u548c\u591a\u79cd\u73af\u5883\u56e0\u7d20\u7684\u5171\u540c\u5f71\u54cd\u3002\u76ee\u524d\u7684 [&hellip;]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[76],"tags":[197,150,151],"_links":{"self":[{"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/posts\/21678"}],"collection":[{"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/comments?post=21678"}],"version-history":[{"count":2,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/posts\/21678\/revisions"}],"predecessor-version":[{"id":21690,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/posts\/21678\/revisions\/21690"}],"wp:attachment":[{"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/media?parent=21678"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/categories?post=21678"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/tags?post=21678"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}