{"id":21914,"date":"2026-05-08T17:55:09","date_gmt":"2026-05-08T09:55:09","guid":{"rendered":"https:\/\/www.hjtdsm.cn\/?p=21914"},"modified":"2026-05-08T17:55:34","modified_gmt":"2026-05-08T09:55:34","slug":"https-www-hjtdsm-cn-stem-cells-stem-cell-therapy-21914-html","status":"publish","type":"post","link":"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/21914.html","title":{"rendered":"\u8de8\u8d8a\u6570\u5341\u8f7d\u9635\u75db\uff0c2025\u5e743\u9879\u91cc\u7a0b\u7891\u7814\u7a76\u8bc1\u5b9e\uff1a\u5e72\u7ec6\u80de\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\u5df2\u89e6\u624b\u53ef\u53ca"},"content":{"rendered":"<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\"><p><strong>\u63cf\u8ff0\uff1a<\/strong>2025\u5e74\u300a\u81ea\u7136\u300b\u7b49\u591a\u9876\u520a\u53d1\u8868\u4e09\u9879\u91cc\u7a0b\u7891\u4e34\u5e8a\u8bd5\u9a8c\uff1aiPSC\u53cahESC\u884d\u751f\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u79fb\u690d\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\uff0c\u9996\u6b21\u5728\u4eba\u4f53\u8bc1\u5b9e\u5b89\u5168\u6027\u3001\u53ef\u884c\u6027\u548c\u5242\u91cf\u4f9d\u8d56\u6027\u8fd0\u52a8\u529f\u80fd\u6539\u5584\u3002\u672c\u6587\u7cfb\u7edf\u89e3\u8bfb\u80ce\u513f\u7ec4\u7ec7\u79fb\u690d\u6559\u8bad\u3001\u73b0\u4ee3\u7ec6\u80de\u7597\u6cd5\u8bbe\u8ba1\u539f\u5219\u3001\u4e09\u9879<span class=\"xintheme_tag_link\">Stem cell therapy for Parkinson's disease<\/span>\u7684\u5173\u952e\u8bd5\u9a8c\u6570\u636e\u53ca\u672a\u6765\u6311\u6218\u3002<\/p><\/blockquote>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_79_2 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewbox=\"0 0 24 24\" version=\"1.2\" baseprofile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 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class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/21914.html\/#%E5%BC%95%E8%A8%80%EF%BC%9A%E5%B8%95%E9%87%91%E6%A3%AE%E7%97%85%E5%86%8D%E7%94%9F%E5%8C%BB%E5%AD%A6%E7%9A%84%E8%BD%AC%E6%8A%98%E6%97%B6%E5%88%BB\" >\u5f15\u8a00\uff1a\u5e15\u91d1\u68ee\u75c5\u518d\u751f\u533b\u5b66\u7684\u8f6c\u6298\u65f6\u523b<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/21914.html\/#%E4%B8%80%E3%80%81%E5%8E%86%E5%8F%B2%E5%9F%BA%E7%9F%B3%EF%BC%9A%E4%BB%8E%E8%83%8E%E5%84%BF%E7%BB%84%E7%BB%87%E7%A7%BB%E6%A4%8D%E4%B8%AD%E6%B1%B2%E5%8F%96%E7%9A%84%E6%95%99%E8%AE%AD\" >\u4e00\u3001\u5386\u53f2\u57fa\u77f3\uff1a\u4ece\u80ce\u513f\u7ec4\u7ec7\u79fb\u690d\u4e2d\u6c72\u53d6\u7684\u6559\u8bad<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/21914.html\/#11_%E6%97%A9%E6%9C%9F%E6%88%90%E5%B0%B1%EF%BC%9A%E6%A6%82%E5%BF%B5%E9%AA%8C%E8%AF%81%E7%9A%84%E5%A5%A0%E5%AE%9A\" >1.1 \u65e9\u671f\u6210\u5c31\uff1a\u6982\u5ff5\u9a8c\u8bc1\u7684\u5960\u5b9a<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/21914.html\/#12_%E5%A4%B1%E8%B4%A5%E4%B8%AD%E6%8F%AD%E7%A4%BA%E7%9A%84%E6%A0%B9%E6%9C%AC%E5%B1%80%E9%99%90\" >1.2 \u5931\u8d25\u4e2d\u63ed\u793a\u7684\u6839\u672c\u5c40\u9650<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/21914.html\/#13_%E6%A0%B8%E5%BF%83%E6%95%99%E8%AE%AD\" >1.3 \u6838\u5fc3\u6559\u8bad<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/21914.html\/#%E4%BA%8C%E3%80%81%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E5%B8%95%E9%87%91%E6%A3%AE%E7%97%85%E7%9A%84%E6%A0%B8%E5%BF%83%E5%8E%9F%E5%88%99\" >\u4e8c\u3001\u5e72\u7ec6\u80de\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\u7684\u6838\u5fc3\u539f\u5219<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/21914.html\/#21_%E7%B2%BE%E7%A1%AE%E9%87%8D%E5%BB%BAA9%E5%9E%8B%E4%B8%AD%E8%84%91%E5%A4%9A%E5%B7%B4%E8%83%BA%E8%83%BD%E7%A5%9E%E7%BB%8F%E5%85%83%E5%91%BD%E8%BF%90\" >2.1 \u7cbe\u786e\u91cd\u5efaA9\u578b\u4e2d\u8111\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u547d\u8fd0<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/21914.html\/#22_%E7%B2%BE%E5%87%86%E9%9D%B6%E5%90%91%E5%A3%B3%E6%A0%B8%E8%BF%9B%E8%A1%8C%E8%A7%A3%E5%89%96%E5%AD%A6%E9%87%8D%E5%BB%BA\" >2.2 \u7cbe\u51c6\u9776\u5411\u58f3\u6838\u8fdb\u884c\u89e3\u5256\u5b66\u91cd\u5efa<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/21914.html\/#23_%E5%BA%94%E5%AF%B9%E5%BC%82%E4%BD%93%E7%A7%BB%E6%A4%8D%E7%9A%84%E5%85%8D%E7%96%AB%E6%8C%91%E6%88%98\" >2.3 \u5e94\u5bf9\u5f02\u4f53\u79fb\u690d\u7684\u514d\u75ab\u6311\u6218<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/21914.html\/#%E4%B8%89%E3%80%812025%E5%B9%B4%E4%B8%89%E9%A1%B9%E9%87%8C%E7%A8%8B%E7%A2%91%E4%B8%B4%E5%BA%8A%E8%AF%95%E9%AA%8C%E8%AF%A6%E8%A7%A3\" >\u4e09\u30012025\u5e74\u4e09\u9879\u91cc\u7a0b\u7891\u4e34\u5e8a\u8bd5\u9a8c\u8be6\u89e3<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/21914.html\/#31_%E8%AF%95%E9%AA%8C%E4%B8%80%EF%BC%9A%E6%97%A5%E6%9C%ACiPSC%E6%BA%90%E5%A4%9A%E5%B7%B4%E8%83%BA%E8%83%BD%E7%BB%86%E8%83%9EIII%E6%9C%9F%E8%AF%95%E9%AA%8C%EF%BC%88Sawamoto%E7%AD%89%EF%BC%8C%E3%80%8A%E8%87%AA%E7%84%B6%E3%80%8B2025%EF%BC%89\" >3.1 \u8bd5\u9a8c\u4e00\uff1a\u65e5\u672ciPSC\u6e90\u591a\u5df4\u80fa\u80fd\u7ec6\u80deI\/II\u671f\u8bd5\u9a8c\uff08Sawamoto\u7b49\uff0c\u300a\u81ea\u7136\u300b2025\uff09<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/21914.html\/#32_%E8%AF%95%E9%AA%8C%E4%BA%8C%EF%BC%9A%E7%BE%8E%E5%9B%BD%E5%8A%A0%E6%8B%BF%E5%A4%A7%E4%BA%BA%E8%83%9A%E8%83%8E%E5%B9%B2%E7%BB%86%E8%83%9E%E6%BA%90%E5%A4%9A%E5%B7%B4%E8%83%BA%E8%83%BD%E7%A5%9E%E7%BB%8F%E5%85%83I%E6%9C%9F%E8%AF%95%E9%AA%8C%EF%BC%88Tabar%E7%AD%89%EF%BC%8CBemdaneprocel%EF%BC%89\" >3.2 \u8bd5\u9a8c\u4e8c\uff1a\u7f8e\u56fd\/\u52a0\u62ff\u5927\u4eba\u80da\u80ce\u5e72\u7ec6\u80de\u6e90\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143I\u671f\u8bd5\u9a8c\uff08Tabar\u7b49\uff0cBemdaneprocel\uff09<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/21914.html\/#33_%E8%AF%95%E9%AA%8C%E4%B8%89%EF%BC%9A%E9%9F%A9%E5%9B%BD%E4%BA%BA%E8%83%9A%E8%83%8E%E5%B9%B2%E7%BB%86%E8%83%9E%E6%BA%90%E5%A4%9A%E5%B7%B4%E8%83%BA%E8%83%BD%E5%89%8D%E4%BD%93%E7%BB%86%E8%83%9E12a%E6%9C%9F%E8%AF%95%E9%AA%8C%EF%BC%88Chang%E7%AD%89%EF%BC%8CTED-A9%EF%BC%89\" >3.3 \u8bd5\u9a8c\u4e09\uff1a\u97e9\u56fd\u4eba\u80da\u80ce\u5e72\u7ec6\u80de\u6e90\u591a\u5df4\u80fa\u80fd\u524d\u4f53\u7ec6\u80de1\/2a\u671f\u8bd5\u9a8c\uff08Chang\u7b49\uff0cTED-A9\uff09<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/21914.html\/#%E5%9B%9B%E3%80%81%E5%89%8D%E7%9E%BB%E4%B8%8E%E6%8C%91%E6%88%98%EF%BC%9A%E9%A9%B6%E5%90%91%E6%9B%B4%E5%B9%BF%E4%B9%89%E7%9A%84%E4%BF%AE%E5%A4%8D\" >\u56db\u3001\u524d\u77bb\u4e0e\u6311\u6218\uff1a\u9a76\u5411\u66f4\u5e7f\u4e49\u7684\u4fee\u590d<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-16\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/21914.html\/#41_%E6%A0%B8%E5%BF%83%E6%8A%80%E6%9C%AF%E7%93%B6%E9%A2%88%EF%BC%9A%E5%86%8D%E7%A5%9E%E7%BB%8F%E6%94%AF%E9%85%8D%E4%B8%8D%E5%9D%87\" >4.1 \u6838\u5fc3\u6280\u672f\u74f6\u9888\uff1a\u518d\u795e\u7ecf\u652f\u914d\u4e0d\u5747<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-17\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/21914.html\/#42_%E7%96%97%E6%95%88%E9%9C%80%E8%B6%85%E8%B6%8A%E7%8E%B0%E6%9C%89%E7%96%97%E6%B3%95\" >4.2 \u7597\u6548\u9700\u8d85\u8d8a\u73b0\u6709\u7597\u6cd5<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-18\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/21914.html\/#43_%E8%81%94%E5%90%88%E6%B2%BB%E7%96%97%E4%BD%93%E7%B3%BB%E7%9A%84%E6%9E%84%E5%BB%BA\" >4.3 \u8054\u5408\u6cbb\u7597\u4f53\u7cfb\u7684\u6784\u5efa<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-19\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/21914.html\/#44_%E6%8A%80%E6%9C%AF%E8%BF%AD%E4%BB%A3%E6%96%B9%E5%90%91\" >4.4 \u6280\u672f\u8fed\u4ee3\u65b9\u5411<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-20\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/21914.html\/#45_%E9%95%BF%E6%9C%9F%E5%AE%89%E5%85%A8%E6%80%A7\" >4.5 \u957f\u671f\u5b89\u5168\u6027<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-21\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/21914.html\/#%E4%BA%94%E3%80%81%E5%B8%B8%E8%A7%81%E9%97%AE%E9%A2%98%E8%A7%A3%E7%AD%94%EF%BC%88FAQ%EF%BC%89\" >\u4e94\u3001\u5e38\u89c1\u95ee\u9898\u89e3\u7b54\uff08FAQ\uff09<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-22\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/21914.html\/#%E9%97%AE1%EF%BC%9A%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E5%B8%95%E9%87%91%E6%A3%AE%E7%97%85%E7%9B%AE%E5%89%8D%E6%88%90%E7%86%9F%E5%90%97%EF%BC%9F%E6%88%91%E5%AE%B6%E4%BA%BA%E8%83%BD%E7%94%A8%E4%B8%8A%E5%90%97%EF%BC%9F\" >\u95ee1\uff1a\u5e72\u7ec6\u80de\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\u76ee\u524d\u6210\u719f\u5417\uff1f\u6211\/\u5bb6\u4eba\u80fd\u7528\u4e0a\u5417\uff1f<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-23\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/21914.html\/#%E9%97%AE2%EF%BC%9A%E8%BF%99%E4%B8%89%E9%A1%B9%E8%AF%95%E9%AA%8C%E7%9A%84%E7%BB%93%E6%9E%9C%E5%88%B0%E5%BA%95%E6%9C%89%E5%A4%9A%E5%A5%BD%EF%BC%9F%E8%83%BD%E6%B2%BB%E5%A5%BD%E5%90%97%EF%BC%9F\" >\u95ee2\uff1a\u8fd9\u4e09\u9879\u8bd5\u9a8c\u7684\u7ed3\u679c\u5230\u5e95\u6709\u591a\u597d\uff1f\u80fd\u6cbb\u597d\u5417\uff1f<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-24\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/21914.html\/#%E9%97%AE3%EF%BC%9AiPSC%E5%92%8ChESC%E6%9C%89%E4%BB%80%E4%B9%88%E5%8C%BA%E5%88%AB%EF%BC%9F%E5%93%AA%E4%B8%AA%E6%9B%B4%E5%A5%BD%EF%BC%9F\" >\u95ee3\uff1aiPSC\u548chESC\u6709\u4ec0\u4e48\u533a\u522b\uff1f\u54ea\u4e2a\u66f4\u597d\uff1f<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-25\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/21914.html\/#%E9%97%AE4%EF%BC%9A%E6%B2%BB%E7%96%97%E8%BF%87%E7%A8%8B%E6%98%AF%E6%80%8E%E6%A0%B7%E7%9A%84%EF%BC%9F%E9%9C%80%E8%A6%81%E5%BC%80%E9%A2%85%E5%90%97%EF%BC%9F\" >\u95ee4\uff1a\u6cbb\u7597\u8fc7\u7a0b\u662f\u600e\u6837\u7684\uff1f\u9700\u8981\u5f00\u9885\u5417\uff1f<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-26\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/21914.html\/#%E9%97%AE5%EF%BC%9A%E6%B2%BB%E7%96%97%E5%90%8E%E8%BF%98%E9%9C%80%E8%A6%81%E5%90%83%E8%8D%AF%E5%90%97%EF%BC%9F%E5%85%8D%E7%96%AB%E6%8A%91%E5%88%B6%E5%89%82%E8%A6%81%E6%9C%8D%E5%A4%9A%E4%B9%85%EF%BC%9F\" >\u95ee5\uff1a\u6cbb\u7597\u540e\u8fd8\u9700\u8981\u5403\u836f\u5417\uff1f\u514d\u75ab\u6291\u5236\u5242\u8981\u670d\u591a\u4e45\uff1f<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-27\" 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href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/21914.html\/#%E9%97%AE8%EF%BC%9A%E9%A2%84%E8%AE%A1%E4%BB%80%E4%B9%88%E6%97%B6%E5%80%99%E8%83%BD%E5%9C%A8%E4%B8%AD%E5%9B%BD%E5%BC%80%E5%B1%95%E4%B8%B4%E5%BA%8A%E8%AF%95%E9%AA%8C%E6%88%96%E4%B8%8A%E5%B8%82%EF%BC%9F\" >\u95ee8\uff1a\u9884\u8ba1\u4ec0\u4e48\u65f6\u5019\u80fd\u5728\u4e2d\u56fd\u5f00\u5c55\u4e34\u5e8a\u8bd5\u9a8c\u6216\u4e0a\u5e02\uff1f<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-30\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/21914.html\/#%E9%97%AE9%EF%BC%9A%E8%AF%95%E9%AA%8C%E4%B8%AD%E6%8F%90%E5%88%B0%E7%9A%84%E2%80%9C%E7%A7%BB%E6%A4%8D%E7%89%A9%E8%AF%B1%E5%AF%BC%E7%9A%84%E8%BF%90%E5%8A%A8%E9%9A%9C%E7%A2%8D%EF%BC%88GIDs%EF%BC%89%E2%80%9D%E6%98%AF%E4%BB%80%E4%B9%88%EF%BC%9F%E4%B8%BA%E4%BB%80%E4%B9%88%E8%BF%99%E6%AC%A1%E8%AF%95%E9%AA%8C%E6%B2%A1%E6%9C%89%EF%BC%9F\" >\u95ee9\uff1a\u8bd5\u9a8c\u4e2d\u63d0\u5230\u7684\u201c\u79fb\u690d\u7269\u8bf1\u5bfc\u7684\u8fd0\u52a8\u969c\u788d\uff08GIDs\uff09\u201d\u662f\u4ec0\u4e48\uff1f\u4e3a\u4ec0\u4e48\u8fd9\u6b21\u8bd5\u9a8c\u6ca1\u6709\uff1f<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-31\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/21914.html\/#%E9%97%AE10%EF%BC%9A%E5%9B%BD%E5%86%85%E6%82%A3%E8%80%85%E5%A6%82%E4%BD%95%E8%8E%B7%E5%8F%96%E6%9C%80%E6%96%B0%E4%BF%A1%E6%81%AF%EF%BC%9F%E6%9C%89%E6%8E%A8%E8%8D%90%E7%9A%84%E5%8C%BB%E9%99%A2%E6%88%96%E4%B8%93%E5%AE%B6%E5%90%97%EF%BC%9F\" >\u95ee10\uff1a\u56fd\u5185\u60a3\u8005\u5982\u4f55\u83b7\u53d6\u6700\u65b0\u4fe1\u606f\uff1f\u6709\u63a8\u8350\u7684\u533b\u9662\u6216\u4e13\u5bb6\u5417\uff1f<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-32\" href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/21914.html\/#%E5%85%AD%E3%80%81%E7%BB%93%E8%AF%AD%EF%BC%9A%E4%BB%8E%E5%8F%AF%E8%83%BD%E8%BF%88%E5%90%91%E6%9B%B4%E4%BC%98\" >\u516d\u3001\u7ed3\u8bed\uff1a\u4ece\u53ef\u80fd\u8fc8\u5411\u66f4\u4f18<\/a><\/li><\/ul><\/li><\/ul><\/nav><\/div>\n<h1 id=\"ftoc-heading-1\" class=\"wp-block-heading ftwp-heading\"><span class=\"ez-toc-section\" id=\"%E8%B7%A8%E8%B6%8A%E6%95%B0%E5%8D%81%E8%BD%BD%E9%98%B5%E7%97%9B%EF%BC%8C2025%E5%B9%B43%E9%A1%B9%E9%87%8C%E7%A8%8B%E7%A2%91%E7%A0%94%E7%A9%B6%E8%AF%81%E5%AE%9E%EF%BC%9A%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E5%B8%95%E9%87%91%E6%A3%AE%E7%97%85%E5%B7%B2%E8%A7%A6%E6%89%8B%E5%8F%AF%E5%8F%8A\"><\/span>\u8de8\u8d8a\u6570\u5341\u8f7d\u9635\u75db\uff0c2025\u5e743\u9879\u91cc\u7a0b\u7891\u7814\u7a76\u8bc1\u5b9e\uff1a<span class=\"xintheme_tag_link\">stem cell therapy<\/span>\u5e15\u91d1\u68ee\u75c5\u5df2\u89e6\u624b\u53ef\u53ca<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<h2 id=\"ftoc-heading-2\" class=\"wp-block-heading ftwp-heading\"><span class=\"ez-toc-section\" id=\"%E5%BC%95%E8%A8%80%EF%BC%9A%E5%B8%95%E9%87%91%E6%A3%AE%E7%97%85%E5%86%8D%E7%94%9F%E5%8C%BB%E5%AD%A6%E7%9A%84%E8%BD%AC%E6%8A%98%E6%97%B6%E5%88%BB\"><\/span>\u5f15\u8a00\uff1a\u5e15\u91d1\u68ee\u75c5\u518d\u751f\u533b\u5b66\u7684\u8f6c\u6298\u65f6\u523b<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><a href=\"https:\/\/www.hjtdsm.cn\/en\/stem-cells\/stem-cell-therapy\/21123.html\/\" target=\"_blank\" rel=\"noopener\">\u5e15\u91d1\u68ee\u75c5\uff08PD\uff09<\/a>\u518d\u751f\u533b\u5b66\u5df2\u6b65\u5165\u8f6c\u6298\u65f6\u523b\u3002\u7ecf\u8fc7\u6570\u5341\u5e74\u7684\u4e34\u5e8a\u524d\u79ef\u6dc0\uff0c\u8fd1\u671f<strong>\u9996\u6b21\u4eba\u4f53\u8bd5\u9a8c<\/strong>\u8bc1\u5b9e\uff0c\u5229\u7528\u5e72\u7ec6\u80de\u884d\u751f\u7684\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u8fdb\u884c\u7ec6\u80de\u66ff\u4ee3\u4e0d\u4ec5\u5b89\u5168\u53ef\u884c\uff0c\u66f4\u663e\u73b0\u51fa\u4ee4\u4eba\u9f13\u821e\u7684\u7597\u6548\u3002<\/p>\n<p>\u4eba\u7c7b\u591a\u80fd\u5e72\u7ec6\u80de\u2014\u2014\u5305\u62ec<strong>\u4eba\u80da\u80ce\u5e72\u7ec6\u80de\uff08hESC\uff09\u4e0e\u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de\uff08iPSC\uff09<\/strong>\u2014\u2014\u5728\u7406\u8bba\u4e0a\u4e3a\u5236\u5907\u6240\u9700\u7684\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u63d0\u4f9b\u4e86\u65e0\u9650\u3001\u6807\u51c6\u5316\u4e14\u4f26\u7406\u53ef\u63a5\u53d7\u7684\u7ec6\u80de\u6765\u6e90\u3002\u4f34\u968f\u7740\u5206\u5316\u65b9\u6848\u7684\u6301\u7eed\u4f18\u5316\uff0c\u53d1\u8868\u4e8e\u300a\u81ea\u7136\u300b\u7684\u9996\u4e2a\u540c\u79cd\u5f02\u4f53iPSC\u884d\u751f\u591a\u5df4\u80fa\u80fd\u7956\u7ec6\u80deI\/II\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u4ee5\u53ca\u540c\u671f\u5176\u4ed6\u8bd5\u9a8c\uff0c\u5171\u540c\u63d0\u4f9b\u4e86\u5b89\u5168\u6027\u3001\u53ef\u884c\u6027\u548c\u65e9\u671f\u7597\u6548\u7684\u5173\u952e\u8bc1\u636e\uff0c\u4f7f\u5e72\u7ec6\u80de\u7597\u6cd5\u4ece\u9065\u8fdc\u7684\u6784\u60f3\u8d70\u5411\u89e6\u624b\u53ef\u53ca\u7684\u73b0\u5b9e\uff0c\u7531\u6b64\u6380\u5f00\u4e86<strong>\u795e\u7ecf\u4fee\u590d\u5b66\u7684\u65b0\u7bc7\u7ae0<\/strong>The<\/p>\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-59838\" src=\"https:\/\/www.hjtdsm.com\/wp-content\/uploads\/2026\/05\/2026050709390058.png\" sizes=\"auto, (max-width: 789px) 100vw, 789px\" srcset=\"https:\/\/www.hjtdsm.com\/wp-content\/uploads\/2026\/05\/2026050709390058.png 789w, https:\/\/www.hjtdsm.com\/wp-content\/uploads\/2026\/05\/2026050709390058-768x371.png 768w\" alt=\"\u8de8\u8d8a\u6570\u5341\u8f7d\u9635\u75db\uff0c2025\u5e743\u9879\u91cc\u7a0b\u7891\u7814\u7a76\u8bc1\u5b9e\uff1a\u5e72\u7ec6\u80de\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\u5df2\u89e6\u624b\u53ef\u53ca\" width=\"789\" height=\"381\" title=\"\"><figcaption><\/figcaption><\/figure>\n<p>\u672c\u6587\u4ee5\u53d1\u8868\u4e8e\u300aTranslational Neurodegeneration\u300b\u4e0a\u7684\u7efc\u8ff0\u201c\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\u7684\u65b0\u66d9\u5149\uff1a\u5173\u4e8e\u5e72\u7ec6\u80de\u7597\u6cd5\u5174\u8d77\u7684\u8bc4\u8bba\u201d\u4e3a\u6846\u67b6<sup><a href=\"https:\/\/link.springer.com\/article\/10.1186\/s40035-026-00556-2\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">[1]<\/a><\/sup>\uff0c\u7cfb\u7edf\u68b3\u7406\u4e09\u98792025\u5e74\u91cc\u7a0b\u7891\u7814\u7a76\uff0c\u56de\u987e\u80ce\u513f\u7ec4\u7ec7\u79fb\u690d\u7684\u5386\u53f2\u542f\u793a\uff0c\u9610\u91ca\u73b0\u4ee3\u7ec6\u80de\u7597\u6cd5\u7684\u8bbe\u8ba1\u539f\u5219\uff0c\u5e76\u5ba1\u89c6\u5f53\u524d\u6311\u6218\u4e0e\u672a\u6765\u65b9\u5411\u3002<\/p>\n<h2 id=\"ftoc-heading-3\" class=\"wp-block-heading ftwp-heading\"><span class=\"ez-toc-section\" id=\"%E4%B8%80%E3%80%81%E5%8E%86%E5%8F%B2%E5%9F%BA%E7%9F%B3%EF%BC%9A%E4%BB%8E%E8%83%8E%E5%84%BF%E7%BB%84%E7%BB%87%E7%A7%BB%E6%A4%8D%E4%B8%AD%E6%B1%B2%E5%8F%96%E7%9A%84%E6%95%99%E8%AE%AD\"><\/span>\u4e00\u3001\u5386\u53f2\u57fa\u77f3\uff1a\u4ece\u80ce\u513f\u7ec4\u7ec7\u79fb\u690d\u4e2d\u6c72\u53d6\u7684\u6559\u8bad<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"11_%E6%97%A9%E6%9C%9F%E6%88%90%E5%B0%B1%EF%BC%9A%E6%A6%82%E5%BF%B5%E9%AA%8C%E8%AF%81%E7%9A%84%E5%A5%A0%E5%AE%9A\"><\/span>1.1 \u65e9\u671f\u6210\u5c31\uff1a\u6982\u5ff5\u9a8c\u8bc1\u7684\u5960\u5b9a<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u80ce\u513f\u7ec4\u7ec7\u79fb\u690d\u7684\u65e9\u671f\u5f00\u653e\u6807\u7b7e\u8bd5\u9a8c\u9996\u6b21\u4ee4\u4eba\u4fe1\u670d\u5730\u8bc1\u660e\uff1a\u79fb\u690d\u7684\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u80fd\u591f\u5728\u4eba\u8111\u4e2d<strong>\u957f\u671f\u5b58\u6d3b\u3001\u6574\u5408\u5165\u5bbf\u4e3b\u795e\u7ecf\u56de\u8def<\/strong>\uff0c\u5e76\u6301\u7eed\u6539\u5584\u4e34\u5e8a\u75c7\u72b6\u3002\u8fd9\u786e\u7acb\u4e86\u7ec6\u80de\u66ff\u4ee3\u7b56\u7565\u6cbb\u7597\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u7684\u53ef\u80fd\u6027\u3002<\/p>\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"12_%E5%A4%B1%E8%B4%A5%E4%B8%AD%E6%8F%AD%E7%A4%BA%E7%9A%84%E6%A0%B9%E6%9C%AC%E5%B1%80%E9%99%90\"><\/span>1.2 \u5931\u8d25\u4e2d\u63ed\u793a\u7684\u6839\u672c\u5c40\u9650<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u968f\u540e\u7684<strong>\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u8bd5\u9a8c<\/strong>\u672a\u8fbe\u5230\u4e3b\u8981\u7ec8\u70b9\uff0c\u8fd8\u66b4\u9732\u51fa\u8f83\u9ad8\u7684<strong>\u79fb\u690d\u7269\u8bf1\u5bfc\u7684\u8fd0\u52a8\u969c\u788d\uff08GIDs\uff09<\/strong>\u00a0\u53d1\u751f\u7387\uff0c\u8feb\u4f7f\u9886\u57df\u4ece\u201c\u80fd\u4e0d\u80fd\u505a\u201d\u8f6c\u5411\u201c\u5982\u4f55\u505a\u5f97\u66f4\u5b89\u5168\u3001\u66f4\u4e00\u81f4\u201d\u3002<\/p>\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"13_%E6%A0%B8%E5%BF%83%E6%95%99%E8%AE%AD\"><\/span>1.3 \u6838\u5fc3\u6559\u8bad<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<figure class=\"wp-block-table is-style-stripes\">\n<table class=\"has-fixed-layout\" style=\"width: 64.916%; height: 216px;\">\n<thead>\n<tr style=\"height: 24px;\">\n<th style=\"height: 24px;\">\u6559\u8bad<\/th>\n<th style=\"height: 24px;\">\u5177\u4f53\u5185\u5bb9<\/th>\n<th style=\"height: 24px;\">\u73b0\u4ee3\u5bf9\u7b56<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr style=\"height: 48px;\">\n<td style=\"height: 48px;\"><strong>\u7ec6\u80de\u7eaf\u5ea6<\/strong><\/td>\n<td style=\"height: 48px;\">\u80ce\u513f\u7ec4\u7ec7\u4e2d\u6df7\u6742\u7684\u8840\u6e05\u7d20\u80fd\u795e\u7ecf\u5143\u662fGIDs\u7684\u5173\u952e\u56e0\u7d20<\/td>\n<td style=\"height: 48px;\">\u751f\u6210\u9ad8\u7eaf\u5ea6\u3001\u6807\u51c6\u5316\u7684\u591a\u5df4\u80fa\u80fd\u7956\u7ec6\u80de\uff0c\u5254\u9664\u8131\u9776\u7ec6\u80de<\/td>\n<\/tr>\n<tr style=\"height: 48px;\">\n<td style=\"height: 48px;\"><strong>\u60a3\u8005\u9009\u62e9<\/strong><\/td>\n<td style=\"height: 48px;\">\u5e74\u8f7b\u3001\u65e9\u671f\u60a3\u8005\u83b7\u76ca\u66f4\u5927\uff0c\u75c5\u7406\u73af\u5883\u5f71\u54cd\u79fb\u690d\u6548\u679c<\/td>\n<td style=\"height: 48px;\">\u4e25\u683c\u7b5b\u9009\u5408\u9002\u65f6\u95f4\u7a97\u7684\u60a3\u8005<\/td>\n<\/tr>\n<tr style=\"height: 48px;\">\n<td style=\"height: 48px;\"><strong>\u514d\u75ab\u6291\u5236<\/strong><\/td>\n<td style=\"height: 48px;\">\u8fc7\u53bb\u65b9\u6848\u4e0d\u5145\u5206\uff0c\u9690\u533f\u6027\u6392\u65a5\u5bfc\u81f4\u7597\u6548\u6ce2\u52a8<\/td>\n<td style=\"height: 48px;\">\u5f3a\u6548\u3001\u6807\u51c6\u5316\u514d\u75ab\u6291\u5236\uff08\u4ed6\u514b\u83ab\u53f8\u7ea615\u4e2a\u6708\uff09<\/td>\n<\/tr>\n<tr style=\"height: 48px;\">\n<td style=\"height: 48px;\"><strong>\u79fb\u690d\u5206\u5e03<\/strong><\/td>\n<td style=\"height: 48px;\">\u58f3\u6838\u201c\u6591\u7247\u72b6\u201d\u795e\u7ecf\u652f\u914d\u5f62\u6210\u5c40\u90e8\u591a\u5df4\u80fa\u70ed\u70b9<\/td>\n<td style=\"height: 48px;\">\u591a\u901a\u9053\u6ce8\u5c04\u6a21\u5f0f\uff0c\u5b9e\u73b0\u66f4\u5747\u5300\u8986\u76d6<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/figure>\n<h2 id=\"ftoc-heading-4\" class=\"wp-block-heading ftwp-heading\"><span class=\"ez-toc-section\" id=\"%E4%BA%8C%E3%80%81%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E5%B8%95%E9%87%91%E6%A3%AE%E7%97%85%E7%9A%84%E6%A0%B8%E5%BF%83%E5%8E%9F%E5%88%99\"><\/span><strong>\u4e8c\u3001\u5e72\u7ec6\u80de\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\u7684\u6838\u5fc3\u539f\u5219<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>\u5e15\u91d1\u68ee\u75c5\u7ec6\u80de\u6cbb\u7597\u7684\u76ee\u6807\u662f<strong>\u901a\u8fc7\u79fb\u690d\u80fd\u591f\u53d1\u80b2\u4e3a\u771f\u6b63\u7684\u3001\u5177\u6709\u529f\u80fd\u7684A9\u578b\u4e2d\u8111\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u7684\u7ec6\u80de\uff0c\u4ece\u800c\u91cd\u5efa\u53d7\u635f\u7684\u795e\u7ecf\u56de\u8def<\/strong>\u2014\u2014\u800cA9\u578b\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u6b63\u662f\u5e15\u91d1\u68ee\u75c5\u4e2d\u4e27\u5931\u7684\u795e\u7ecf\u5143\u4e9a\u7fa4\u3002\u8fd9\u4e9bA9\u578b\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u4e13\u95e8\u6295\u5c04\u81f3\u80cc\u4fa7\u58f3\u6838\uff0c\u5373\u7eb9\u72b6\u4f53\u7684\u8fd0\u52a8\u533a\u3002<\/p>\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-59839\" title=\"\u8de8\u8d8a\u6570\u5341\u8f7d\u9635\u75db\uff0c2025\u5e743\u9879\u91cc\u7a0b\u7891\u7814\u7a76\u8bc1\u5b9e\uff1a\u5e72\u7ec6\u80de\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\u5df2\u89e6\u624b\u53ef\u53ca\" src=\"https:\/\/www.hjtdsm.com\/wp-content\/uploads\/2026\/05\/2026050709401373.png\" sizes=\"auto, (max-width: 1376px) 100vw, 1376px\" srcset=\"https:\/\/www.hjtdsm.com\/wp-content\/uploads\/2026\/05\/2026050709401373.png 1376w, https:\/\/www.hjtdsm.com\/wp-content\/uploads\/2026\/05\/2026050709401373-768x429.png 768w\" alt=\"\u8de8\u8d8a\u6570\u5341\u8f7d\u9635\u75db\uff0c2025\u5e743\u9879\u91cc\u7a0b\u7891\u7814\u7a76\u8bc1\u5b9e\uff1a\u5e72\u7ec6\u80de\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\u5df2\u89e6\u624b\u53ef\u53ca\" width=\"1376\" height=\"768\" \/><figcaption class=\"wp-element-caption\">\u8de8\u8d8a\u6570\u5341\u8f7d\u9635\u75db\uff0c2025\u5e743\u9879\u91cc\u7a0b\u7891\u7814\u7a76\u8bc1\u5b9e\uff1a\u5e72\u7ec6\u80de\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\u5df2\u89e6\u624b\u53ef\u53ca<\/figcaption><\/figure>\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"21_%E7%B2%BE%E7%A1%AE%E9%87%8D%E5%BB%BAA9%E5%9E%8B%E4%B8%AD%E8%84%91%E5%A4%9A%E5%B7%B4%E8%83%BA%E8%83%BD%E7%A5%9E%E7%BB%8F%E5%85%83%E5%91%BD%E8%BF%90\"><\/span><strong>2.1 \u7cbe\u786e\u91cd\u5efaA9\u578b\u4e2d\u8111\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u547d\u8fd0<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u5e72\u7ec6\u80de\u7597\u6cd5\u7684\u9996\u8981\u539f\u5219\uff0c\u662f<strong>\u901a\u8fc7\u6a21\u62df\u80da\u80ce\u53d1\u80b2\u4fe1\u53f7\uff0c\u5c06\u4eba\u591a\u80fd\u5e72\u7ec6\u80de\u5b9a\u5411\u5206\u5316\u4e3a\u529f\u80fd\u6027A9\u578b\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143<\/strong>\u3002\u8fd9\u4e00\u8fc7\u7a0b\u5305\u62ec\uff1a\u901a\u8fc7\u53cc\u91cdSMAD\u6291\u5236\u963b\u65adBMP\u7b49\u975e\u795e\u7ecf\u901a\u8def\uff0c\u5b8c\u6210\u795e\u7ecf\u5b9a\u5411\u8bf1\u5bfc\uff1b\u5229\u7528\u97f3\u732c\u56e0\u5b50\u63d0\u4f9b\u8179\u4fa7\u5316\u4fe1\u53f7\uff0c\u5e76\u65f6\u5e8f\u6027\u8c03\u63a7Wnt\u901a\u8def\u4ee5\u786e\u7acb\u4e2d\u8111\u8eab\u4efd\uff1b\u8bf1\u5bfc\u8868\u8fbe\u5e95\u677f\u4e2d\u95f4\u9636\u6bb5\u6807\u5fd7\u7269LMX1A\u4e0eFOXA2\uff0c\u5e76\u5171\u8868\u8fbeOTX2\u3001EN1\uff0c\u4ee5\u9501\u5b9a\u771f\u6b63\u7684A9\u7956\u7ec6\u80de\u8eab\u4efd\uff1b\u79fb\u690d\u540e\uff0c\u7956\u7ec6\u80de\u5728\u5bbf\u4e3b\u73af\u5883\u4e2d\u5386\u7ecf\u6570\u6708\u7ec8\u672b\u5206\u5316\uff0c\u5b9e\u73b0\u7a81\u89e6\u5f62\u6210\u548c\u529f\u80fd\u6027\u591a\u5df4\u80fa\u91ca\u653e\uff0c\u6700\u7ec8\u91cd\u5efa\u53d7\u635f\u795e\u7ecf\u56de\u8def\u3002<\/p>\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"22_%E7%B2%BE%E5%87%86%E9%9D%B6%E5%90%91%E5%A3%B3%E6%A0%B8%E8%BF%9B%E8%A1%8C%E8%A7%A3%E5%89%96%E5%AD%A6%E9%87%8D%E5%BB%BA\"><\/span><strong>2.2 \u7cbe\u51c6\u9776\u5411\u58f3\u6838\u8fdb\u884c\u89e3\u5256\u5b66\u91cd\u5efa<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u6cbb\u7597\u7b56\u7565\u7684\u6838\u5fc3\u539f\u5219\u662f\u5c06\u7956\u7ec6\u80de\u7acb\u4f53\u5b9a\u5411\u79fb\u690d\u81f3\u58f3\u6838\uff0c\u5c24\u5176\u662f\u80cc\u4fa7\u8fd0\u52a8\u533a\uff0c\u4ee5\u8fbe\u6210\u5f02\u4f4d\u4f46\u529f\u80fd\u6027\u7684\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u652f\u914d\u3002<strong>\u76f4\u63a5\u7ed5\u8fc7\u5931\u9000\u5316\u7684\u9ed1\u8d28\uff0c\u5c06\u4ea7\u591a\u5df4\u80fa\u7ec6\u80de\u9012\u9001\u81f3\u7eb9\u72b6\u4f53\u8fd0\u52a8\u533a\u5ba4\uff0c\u65e8\u5728\u6062\u590d\u8fd0\u52a8\u73af\u8def\u529f\u80fd<\/strong>The<\/p>\n<p>\u624b\u672f\u4e0a\uff0c\u91c7\u7528\u591a\u9488\u9053\u3001\u591a\u70b9\u6c89\u79ef\u201c\u7a81\u89e6\u5c0f\u4f53\u201d\u7684\u65b9\u5f0f\uff0c\u786e\u4fdd\u5e7f\u6cdb\u800c\u5747\u5300\u7684\u795e\u7ecf\u652f\u914d\uff0c\u907f\u514d\u6591\u7247\u72b6\u591a\u5df4\u80fa\u6c34\u5e73\uff1b\u540c\u65f6\u4f7f\u7528\u4e13\u7528\u5fae\u578b\u5957\u7ba1\u4ee5\u51cf\u8f7b\u5bbf\u4e3b\u7ec4\u7ec7\u673a\u68b0\u635f\u4f24\u4e0e\u5c40\u90e8\u708e\u75c7\uff0c\u63d0\u9ad8\u7ec6\u80de\u5b58\u6d3b\u7387\u3002\u6b64\u5916\uff0c\u8f6c\u5411\u540c\u79cd\u5f02\u4f53HLA\u7eaf\u5408\u4f9b\u4f53iPSC\u7cfb\uff0c\u53ef\u63a8\u52a8\u6807\u51c6\u5316\u751f\u4ea7\u3001\u5242\u91cf\u4e00\u81f4\u6027\u4e0e\u53ef\u6269\u5c55\u6027\uff0c\u8fc8\u5411\u5373\u7528\u578b\u7ec6\u80de\u4ea7\u54c1\u3002<\/p>\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"23_%E5%BA%94%E5%AF%B9%E5%BC%82%E4%BD%93%E7%A7%BB%E6%A4%8D%E7%9A%84%E5%85%8D%E7%96%AB%E6%8C%91%E6%88%98\"><\/span><strong>2.3 \u5e94\u5bf9\u5f02\u4f53\u79fb\u690d\u7684\u514d\u75ab\u6311\u6218<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u9488\u5bf9\u540c\u79cd\u5f02\u4f53\u201c\u5373\u7528\u578b\u201d\u7ec6\u80de\u4ea7\u54c1\uff0c\u987b\u606a\u5b88\u514d\u75ab\u6291\u5236\u4e0e\u672a\u6765\u514d\u75ab\u9003\u9038\u7684\u539f\u5219\u3002\u79fb\u690d\u540e\u9700\u4f7f\u7528\u4ed6\u514b\u83ab\u53f8\u7b49\u836f\u7269\u7ea615\u4e2a\u6708\uff0c\u6291\u5236T\u7ec6\u80de\u6d3b\u5316\uff0c\u964d\u4f4e\u56e0\u8840\u8111\u5c4f\u969c\u7834\u574f\u548c\u5916\u6e90\u6027HLA\u6807\u8bb0\u6240\u5f15\u53d1\u7684\u514d\u75ab\u653b\u51fb\u3002\u9009\u7528\u5e38\u89c1HLA\u5355\u500d\u578b\u4f9b\u4f53\u7ec6\u80de\u7cfb\u53ef\u7f29\u5c0f\u514d\u75ab\u8ddd\u79bb\uff0c\u4f46\u4e34\u5e8a\u6570\u636e\u663e\u793a\uff0c\u5339\u914d\u4e0e\u5426\u5bf9\u5b89\u5168\u6027\u53ca\u7597\u6548\u5f71\u54cd\u5e76\u4e0d\u663e\u8457\u3002<\/p>\n<p>\u5f53\u524d\u5b9e\u8df5\u901a\u5e38\u5728\u672f\u540e1\u81f31.5\u5e74\u505c\u7528\u514d\u75ab\u6291\u5236\u5242\uff0c\u7136\u800c\u6162\u6027\u4f4e\u5ea6\u708e\u75c7\u6216\u5ef6\u8fdf\u6392\u65a5\u7684\u98ce\u9669\u4f9d\u7136\u5b58\u5728\uff0c\u6210\u4e3a\u9886\u57df\u5185\u60ac\u800c\u672a\u51b3\u7684\u6838\u5fc3\u95ee\u9898\u3002\u672a\u6765\uff0c\u501f\u52a9CRISPR\/Cas9\u7f16\u8f91MHC\u5206\u5b50\uff0c\u5f00\u53d1\u201c\u514d\u75ab\u9003\u9038\u201d\u6216\u901a\u7528\u4f9b\u4f53\u7ec6\u80de\uff0c\u6709\u671b\u5f7b\u5e95\u514d\u9664\u957f\u671f\u5168\u8eab\u514d\u75ab\u6291\u5236\uff0c\u4f7f\u518d\u751f\u7597\u6cd5\u771f\u6b63\u53ef\u53ca\u3002<\/p>\n<h2 id=\"ftoc-heading-5\" class=\"wp-block-heading ftwp-heading\"><span class=\"ez-toc-section\" id=\"%E4%B8%89%E3%80%812025%E5%B9%B4%E4%B8%89%E9%A1%B9%E9%87%8C%E7%A8%8B%E7%A2%91%E4%B8%B4%E5%BA%8A%E8%AF%95%E9%AA%8C%E8%AF%A6%E8%A7%A3\"><\/span><strong>\u4e09\u30012025\u5e74\u4e09\u9879\u91cc\u7a0b\u7891\u4e34\u5e8a\u8bd5\u9a8c\u8be6\u89e3<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>2025\u5e74\u662f\u795e\u7ecf\u4fee\u590d\u5b66\u9886\u57df\u7684\u4e00\u4e2a\u91cc\u7a0b\u7891\uff0c\u6807\u5fd7\u7740\u4e09\u9879\u5730\u57df\u548c\u6280\u672f\u5404\u5f02\u7684\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u51e0\u4e4e\u540c\u65f6\u53d1\u8868\u3002\u8fd9\u4e9b\u7814\u7a76\u5171\u540c\u786e\u7acb\u4e86\u5b89\u5168\u6027\u662f\u5e15\u91d1\u68ee\u75c5\u5e72\u7ec6\u80de\u7597\u6cd5\u7684\u4e00\u9879\u57fa\u7840\u6027\u91cc\u7a0b\u7891\uff08\u56fe1\uff09\u3002\u4e3a\u4e86\u5bf9\u8fd9\u4e09\u9879\u5177\u6709\u91cc\u7a0b\u7891\u610f\u4e49\u76842025\u5e74\u4e34\u5e8a\u8bd5\u9a8c\u8fdb\u884c\u5168\u9762\u9610\u8ff0\uff0c\u4e0b\u6587\u5c06\u603b\u7ed3\u6bcf\u9879\u7814\u7a76\u7684\u8bd5\u9a8c\u8bbe\u8ba1\u3001\u5b89\u5168\u6027\u7ed3\u679c\u548c\u7597\u6548\u4fe1\u53f7\uff08\u88681\uff09\u3002<\/p>\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-59837\" title=\"\u56fe1-2025\u5e74\u5e15\u91d1\u68ee\u75c5\u5e72\u7ec6\u80de\u6cbb\u7597\u4e09\u9879\u91cc\u7a0b\u7891\u4e34\u5e8a\u8bd5\u9a8c\u6bd4\u8f83\" src=\"https:\/\/www.hjtdsm.com\/wp-content\/uploads\/2026\/05\/202605070938566.png\" sizes=\"auto, (max-width: 1960px) 100vw, 1960px\" srcset=\"https:\/\/www.hjtdsm.com\/wp-content\/uploads\/2026\/05\/202605070938566.png 1960w, https:\/\/www.hjtdsm.com\/wp-content\/uploads\/2026\/05\/202605070938566-768x500.png 768w, https:\/\/www.hjtdsm.com\/wp-content\/uploads\/2026\/05\/202605070938566-1536x1000.png 1536w\" alt=\"\u56fe1\u8bf4\u660e\uff1a\u4e09\u9879\u9996\u4e2a\u4eba\u4f53\u4e34\u5e8a\u8bd5\u9a8c\u6bd4\u8f83\u6982\u8ff0\u2014\u2014\u65e5\u672c\u7684Sawamoto\u8bd5\u9a8c\uff08iPSC\uff09\u3001\u7f8e\u56fd\/\u52a0\u62ff\u5927\u7684Tabar\u8bd5\u9a8c\uff08hESC\uff0cBemdaneprocel\uff09\u3001\u97e9\u56fd\u7684Chang\u8bd5\u9a8c\uff08hESC\uff0cTED-A9\uff09\u3002\" width=\"1960\" height=\"1276\" \/><figcaption class=\"wp-element-caption\"><strong>\u56fe1\u8bf4\u660e<\/strong>\uff1a\u4e09\u9879\u9996\u4e2a\u4eba\u4f53\u4e34\u5e8a\u8bd5\u9a8c\u6bd4\u8f83\u6982\u8ff0\u2014\u2014\u65e5\u672c\u7684Sawamoto\u8bd5\u9a8c\uff08iPSC\uff09\u3001\u7f8e\u56fd\/\u52a0\u62ff\u5927\u7684Tabar\u8bd5\u9a8c\uff08hESC\uff0cBemdaneprocel\uff09\u3001\u97e9\u56fd\u7684Chang\u8bd5\u9a8c\uff08hESC\uff0cTED-A9\uff09\u3002<\/figcaption><\/figure>\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-59836\" title=\"\u88681\uff1a\u5e15\u91d1\u68ee\u75c5\u6cbb\u7597\u4e2d\u5e94\u7528hPSCs\u7684\u4e34\u5e8a\u8bd5\u9a8c\u603b\u7ed3\" src=\"https:\/\/www.hjtdsm.com\/wp-content\/uploads\/2026\/05\/2026050709385365.png\" sizes=\"auto, (max-width: 1254px) 100vw, 1254px\" srcset=\"https:\/\/www.hjtdsm.com\/wp-content\/uploads\/2026\/05\/2026050709385365.png 1254w, https:\/\/www.hjtdsm.com\/wp-content\/uploads\/2026\/05\/2026050709385365-768x282.png 768w\" alt=\"\u88681\uff1a\u5e15\u91d1\u68ee\u75c5\u6cbb\u7597\u4e2d\u5e94\u7528hPSCs\u7684\u4e34\u5e8a\u8bd5\u9a8c\u603b\u7ed3\" width=\"1254\" height=\"460\" \/><figcaption class=\"wp-element-caption\">\u88681\uff1a\u5e15\u91d1\u68ee\u75c5\u6cbb\u7597\u4e2d\u5e94\u7528hPSCs\u7684\u4e34\u5e8a\u8bd5\u9a8c\u603b\u7ed3<\/figcaption><\/figure>\n<h3><span class=\"ez-toc-section\" id=\"31_%E8%AF%95%E9%AA%8C%E4%B8%80%EF%BC%9A%E6%97%A5%E6%9C%ACiPSC%E6%BA%90%E5%A4%9A%E5%B7%B4%E8%83%BA%E8%83%BD%E7%BB%86%E8%83%9EIII%E6%9C%9F%E8%AF%95%E9%AA%8C%EF%BC%88Sawamoto%E7%AD%89%EF%BC%8C%E3%80%8A%E8%87%AA%E7%84%B6%E3%80%8B2025%EF%BC%89\"><\/span><strong>3.1 \u8bd5\u9a8c\u4e00\uff1a\u65e5\u672ciPSC\u6e90\u591a\u5df4\u80fa\u80fd\u7ec6\u80deI\/II\u671f\u8bd5\u9a8c\uff08Sawamoto\u7b49\uff0c\u300a\u81ea\u7136\u300b2025\uff09<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u8fd9\u9879\u91cc\u7a0b\u7891\u5f0f\u7814\u7a76\u4f7f\u7528\u4e86\u6e90\u81ea\u4e34\u5e8a\u7ea7iPSC\u7ec6\u80de\u7cfb\u7684\u65b0\u9c9c\u591a\u5df4\u80fa\u80fd\u7956\u7ec6\u80de\u3002\u4e3a\u517c\u987e\u53ef\u6269\u5c55\u6027\u4e0e\u4f4e\u6392\u65a5\u98ce\u9669\uff0c\u7814\u7a76\u4eba\u5458\u91c7\u7528\u4e00\u540d\u5065\u5eb7\u4f9b\u4f53\u7684\u540c\u79cd\u5f02\u4f53\u7ec6\u80de\uff0c\u8be5\u4f9b\u4f53\u643a\u5e26\u5e38\u89c1HLA\u5355\u500d\u578b\u7684\u7eaf\u5408\u5b50\uff0c\u4e0e\u7ea617%\u7684\u65e5\u672c\u4eba\u7fa4\u76f8\u5339\u914d\u3002\u8bd5\u9a8c\u91c7\u7528\u5242\u91cf\u9012\u589e\u8bbe\u8ba1\uff0c\u4f4e\u5242\u91cf\u7ec43\u4f8b\uff08\u6bcf\u4fa7\u534a\u74032.1\u20132.6\u00d710\u2076\u4e2a\u7ec6\u80de\uff09\uff0c\u9ad8\u5242\u91cf\u7ec44\u4f8b\uff08\u6bcf\u4fa7\u534a\u74035.3\u20135.5\u00d710\u2076\u4e2a\u7ec6\u80de\uff09\uff0c\u672f\u540e\u5747\u7ef4\u6301\u4ed6\u514b\u83ab\u53f815\u4e2a\u6708\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u65e0\u8bba\u60a3\u8005\u4e0e\u4f9b\u4f53\u7ec6\u80de\u7cfbHLA\u5339\u914d\u4e0e\u5426\uff0c\u5747\u88ab\u7eb3\u5165\u7814\u7a76<sup>[2]<\/sup>The<\/p>\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-59835\" title=\"\u5e15\u91d1\u68ee\u75c5iPS\u7ec6\u80de\u884d\u751f\u591a\u5df4\u80fa\u80fd\u7ec6\u80de\u7684I\/II\u671f\u4e34\u5e8a\u8bd5\u9a8c\" src=\"https:\/\/www.hjtdsm.com\/wp-content\/uploads\/2026\/05\/2026050709385078.png\" sizes=\"auto, (max-width: 770px) 100vw, 770px\" srcset=\"https:\/\/www.hjtdsm.com\/wp-content\/uploads\/2026\/05\/2026050709385078.png 770w, https:\/\/www.hjtdsm.com\/wp-content\/uploads\/2026\/05\/2026050709385078-768x511.png 768w\" alt=\"\u5e15\u91d1\u68ee\u75c5iPS\u7ec6\u80de\u884d\u751f\u591a\u5df4\u80fa\u80fd\u7ec6\u80de\u7684I\/II\u671f\u4e34\u5e8a\u8bd5\u9a8c\" width=\"770\" height=\"512\" \/><figcaption class=\"wp-element-caption\">\u5e15\u91d1\u68ee\u75c5iPS\u7ec6\u80de\u884d\u751f\u591a\u5df4\u80fa\u80fd\u7ec6\u80de\u7684I\/II\u671f\u4e34\u5e8a\u8bd5\u9a8c<\/figcaption><\/figure>\n<p>24\u4e2a\u6708\u7684\u5b89\u5168\u6027\u7ed3\u679c\u6781\u4e3a\u79ef\u6781\uff1a\u65e0\u79fb\u690d\u7269\u76f8\u5173\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\uff0c\u65e0\u6b7b\u4ea1\u3001\u80bf\u7624\u6216\u79fb\u690d\u7269\u8fc7\u5ea6\u751f\u957f\u3002\u8fde\u7eed\u78c1\u5171\u632f\u6210\u50cf\u53ca\u00b9\u2078F-FLT PET\u5747\u672a\u53d1\u73b0\u589e\u6b96\u4fe1\u53f7\u3002\u5c24\u4e3a\u5173\u952e\u7684\u662f\uff0c\u672a\u62a5\u544a\u4efb\u4f55\u79fb\u690d\u7269\u8bf1\u5bfc\u7684\u8fd0\u52a8\u969c\u788d\uff0c\u8fd9\u88ab\u5f52\u529f\u4e8e\u9ad8\u7eaf\u5ea6CORIN\u9633\u6027\u7956\u7ec6\u80de\u4ee5\u53ca\u8840\u6e05\u7d20\u80fd\u795e\u7ecf\u5143\u7684\u5254\u9664\u3002<strong>\u7597\u6548\u4fe1\u53f7\u540c\u6837\u4ee4\u4eba\u9f13\u821e\uff1a6\u4f8b\u53ef\u8bc4\u4f30\u60a3\u8005\u4e2d\uff0c4\u4f8b\u5728\u201c\u505c\u836f\u201d\u72b6\u6001\u4e0bMDS-UPDRS\u7b2c\u4e09\u90e8\u5206\u51fa\u73b0\u6539\u5584\uff0c\u5e73\u5747\u964d\u4f4e9.5\u5206\uff0820.4%\uff09<\/strong>\u3002\u00b9\u2078F-L-DOPA PET\u663e\u50cf\u63d0\u4f9b\u4e86\u79fb\u690d\u7269\u529f\u80fd\u7684\u5ba2\u89c2\u8bc1\u636e\uff0c\u5e76\u5448\u73b0\u663e\u8457\u7684\u5242\u91cf\u4f9d\u8d56\u6027\u6548\u5e94\u2014\u2014\u9ad8\u5242\u91cf\u7ec4\u591a\u5df4\u80fa\u5408\u6210\u589e\u52a063.5%\uff0c\u800c\u4f4e\u5242\u91cf\u7ec4\u4ec5\u589e\u52a07.0%\u3002<\/p>\n<h3><span class=\"ez-toc-section\" id=\"32_%E8%AF%95%E9%AA%8C%E4%BA%8C%EF%BC%9A%E7%BE%8E%E5%9B%BD%E5%8A%A0%E6%8B%BF%E5%A4%A7%E4%BA%BA%E8%83%9A%E8%83%8E%E5%B9%B2%E7%BB%86%E8%83%9E%E6%BA%90%E5%A4%9A%E5%B7%B4%E8%83%BA%E8%83%BD%E7%A5%9E%E7%BB%8F%E5%85%83I%E6%9C%9F%E8%AF%95%E9%AA%8C%EF%BC%88Tabar%E7%AD%89%EF%BC%8CBemdaneprocel%EF%BC%89\"><\/span><strong>3.2 \u8bd5\u9a8c\u4e8c\uff1a\u7f8e\u56fd\/\u52a0\u62ff\u5927\u4eba\u80da\u80ce\u5e72\u7ec6\u80de\u6e90\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143I\u671f\u8bd5\u9a8c\uff08Tabar\u7b49\uff0cBemdaneprocel\uff09<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>BlueRock Therapeutics\u516c\u53f8\u7684\u8bd5\u9a8c\uff08\u7814\u7a76bemdaneprocel\uff0c\u5e38\u4ee5\u9996\u5e2d\u5916\u79d1\u533b\u751f\u547d\u540d\u79f0\u4e3a\u201cTabar\u8bd5\u9a8c\u201d\uff09\u4f7f\u7528\u4e86\u6e90\u81ea\u4eba\u80da\u80ce\u5e72\u7ec6\u80de\uff08hESC\uff09\u7684\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u524d\u4f53\u7ec6\u80de\u3002\u8fd9\u9879\u591a\u4e2d\u5fc3\u3001\u5f00\u653e\u6807\u7b7e\u7814\u7a76\u5171\u7eb3\u516512\u540d\u53c2\u4e0e\u8005\uff0c\u5206\u4e3a\u4e24\u4e2a\u961f\u5217\uff1a\u4f4e\u5242\u91cf\u7ec4\u6bcf\u4fa7\u58f3\u6838\u63a5\u53d790\u4e07\u4e2a\u7ec6\u80de\uff0c\u9ad8\u5242\u91cf\u7ec4\u6bcf\u4fa7\u58f3\u6838\u63a5\u53d7270\u4e07\u4e2a\u7ec6\u80de\u3002\u4e0eiPSC\u8bd5\u9a8c\u7c7b\u4f3c\uff0c\u53c2\u4e0e\u8005\u63a5\u53d7\u4e86\u4e3a\u671f\u4e00\u5e74\u7684\u514d\u75ab\u6291\u5236\u6cbb\u7597\u4ee5\u4fc3\u8fdb\u79fb\u690d\u7269\u5b58\u6d3b<sup>[3]<\/sup>The<\/p>\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-59834\" title=\"\u5229\u7528\u4eba\u80da\u80ce\u5e72\u7ec6\u80de\u884d\u751f\u7684\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\u7684I\u671f\u4e34\u5e8a\u8bd5\u9a8c\" src=\"https:\/\/www.hjtdsm.com\/wp-content\/uploads\/2026\/05\/2026050709384822.png\" alt=\"\u5229\u7528\u4eba\u80da\u80ce\u5e72\u7ec6\u80de\u884d\u751f\u7684\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\u7684I\u671f\u4e34\u5e8a\u8bd5\u9a8c\" width=\"749\" height=\"446\" \/><figcaption class=\"wp-element-caption\">\u5229\u7528\u4eba\u80da\u80ce\u5e72\u7ec6\u80de\u884d\u751f\u7684\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\u7684I\u671f\u4e34\u5e8a\u8bd5\u9a8c<\/figcaption><\/figure>\n<p>\u8bd5\u9a8c\u8fbe\u5230\u4e86\u8bc1\u660e\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u7684\u4e3b\u8981\u7ec8\u70b9\uff0c\u5728\u968f\u8bbf\u671f\u95f4\u672a\u62a5\u544a\u4e0e\u7ec6\u80de\u4ea7\u54c1\u76f8\u5173\u7684\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\u3002\u8fde\u7eed\u5f71\u50cf\u5b66\u548c\u4e34\u5e8a\u8bc4\u4f30\u8bc1\u5b9e\u4e86\u65e0\u80bf\u7624\u6216\u79fb\u690d\u7269\u8bf1\u5bfc\u7684\u8fd0\u52a8\u969c\u788d\uff08GIDs\uff09\u3002\u63a2\u7d22\u6027\u7597\u6548\u6570\u636e\u975e\u5e38\u4ee4\u4eba\u9f13\u821e\uff0c<strong>\u5c24\u5176\u662f\u5728\u9ad8\u5242\u91cf\u7ec4\u4e2d\uff0c\u8be5\u7ec4\u60a3\u8005\u5728\u4e00\u5e74\u65f6\u7684MDS-UPDRS\u7b2c\u4e09\u90e8\u5206\u201c\u505c\u836f\u201d\u72b6\u6001\u4e0b\u5e73\u5747\u6539\u5584\u4e8623.0\u5206\u3002\u8fd0\u52a8\u83b7\u76ca\u5728\u79fb\u690d\u540e18\u4e2a\u6708\u4ecd\u5f97\u4ee5\u7ef4\u6301\uff0c\u4e14\u9ad8\u5242\u91cf\u7ec4\u5728\u514d\u75ab\u6291\u5236\u505c\u836f\u540e\u89c2\u5bdf\u5230\u6301\u7eed\u6539\u5584<\/strong>\u3002PET\u663e\u50cf\u8bc1\u5b9e\u4e86\u8fd9\u4e9b\u4e34\u5e8a\u53d1\u73b0\uff0c\u663e\u793a\u4e86\u7ec6\u80de\u5b58\u6d3b\u548c\u529f\u80fd\u6027\u79fb\u690d\u7269\u6574\u5408\u7684\u6301\u7eed\u8bc1\u636e\u3002<\/p>\n<h3><span class=\"ez-toc-section\" id=\"33_%E8%AF%95%E9%AA%8C%E4%B8%89%EF%BC%9A%E9%9F%A9%E5%9B%BD%E4%BA%BA%E8%83%9A%E8%83%8E%E5%B9%B2%E7%BB%86%E8%83%9E%E6%BA%90%E5%A4%9A%E5%B7%B4%E8%83%BA%E8%83%BD%E5%89%8D%E4%BD%93%E7%BB%86%E8%83%9E12a%E6%9C%9F%E8%AF%95%E9%AA%8C%EF%BC%88Chang%E7%AD%89%EF%BC%8CTED-A9%EF%BC%89\"><\/span><strong>3.3 \u8bd5\u9a8c\u4e09\uff1a\u97e9\u56fd\u4eba\u80da\u80ce\u5e72\u7ec6\u80de\u6e90\u591a\u5df4\u80fa\u80fd\u524d\u4f53\u7ec6\u80de1\/2a\u671f\u8bd5\u9a8c\uff08Chang\u7b49\uff0cTED-A9\uff09<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u8be5\u9879\u5728\u97e9\u56fd\u5f00\u5c55\u7684\u5355\u4e2d\u5fc3\u3001\u5242\u91cf\u9012\u589e\u8bd5\u9a8c\uff0c\u8bc4\u4f30\u4e86\u540c\u6837\u6e90\u81ea\u4eba\u80da\u80ce\u5e72\u7ec6\u80de\u7684\u9ad8\u7eaf\u5ea6A9\u578b\u591a\u5df4\u80fa\u80fd\u524d\u4f53\u7ec6\u80deTED-A9\uff0c\u5171\u7eb3\u516512\u4f8b\u4e2d\u91cd\u5ea6\u5e15\u91d1\u68ee\u75c5\u60a3\u8005\uff0c\u884c\u53cc\u4fa7\u58f3\u6838\u79fb\u690d\u3002\u60a3\u8005\u5206\u4e3a\u4f4e\u5242\u91cf\u7ec4\uff08315\u4e07\u4e2a\u7ec6\u80de\uff09\u548c\u9ad8\u5242\u91cf\u7ec4\uff08630\u4e07\u4e2a\u7ec6\u80de\uff09\uff0c\u5e76\u63a5\u53d7\u6807\u51c6\u5316\u4e00\u5e74\u514d\u75ab\u6291\u5236\u65b9\u6848<sup>[4]<\/sup>The<\/p>\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-59833 aligncenter\" title=\"\u5e15\u91d1\u68ee\u75c5\u4e2d\u4eba\u80da\u80ce\u5e72\u7ec6\u80de\u884d\u751f\u591a\u5df4\u80fa\u7956\u7ec6\u80de\u76841\/2a\u671f\u4e34\u5e8a\u8bd5\u9a8c\" src=\"https:\/\/www.hjtdsm.com\/wp-content\/uploads\/2026\/05\/2026050709384568.png\" sizes=\"auto, (max-width: 1121px) 100vw, 1121px\" srcset=\"https:\/\/www.hjtdsm.com\/wp-content\/uploads\/2026\/05\/2026050709384568.png 1121w, https:\/\/www.hjtdsm.com\/wp-content\/uploads\/2026\/05\/2026050709384568-768x276.png 768w\" alt=\"\u5e15\u91d1\u68ee\u75c5\u4e2d\u4eba\u80da\u80ce\u5e72\u7ec6\u80de\u884d\u751f\u591a\u5df4\u80fa\u7956\u7ec6\u80de\u76841\/2a\u671f\u4e34\u5e8a\u8bd5\u9a8c\" width=\"1121\" height=\"403\" \/><figcaption class=\"wp-element-caption\">\u5e15\u91d1\u68ee\u75c5\u4e2d\u4eba\u80da\u80ce\u5e72\u7ec6\u80de\u884d\u751f\u591a\u5df4\u80fa\u7956\u7ec6\u80de\u76841\/2a\u671f\u4e34\u5e8a\u8bd5\u9a8c<\/figcaption><\/figure>\n<p>\u5b89\u5168\u6027\u7ed3\u679c\u4e0e\u5176\u4ed6\u91cc\u7a0b\u7891\u8bd5\u9a8c\u4e00\u81f4\uff1a\u65e0\u5242\u91cf\u9650\u5236\u6027\u6bd2\u6027\uff0c\u65e0\u79fb\u690d\u7269\u76f8\u5173\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\uff0c\u65e0\u80bf\u7624\u5f62\u6210\u6216\u8fc7\u5ea6\u751f\u957f\u8bc1\u636e\u3002<strong>12\u4e2a\u6708\u65f6\uff0cMDS-UPDRS\u7b2c\u4e09\u90e8\u5206\u201c\u505c\u836f\u201d\u72b6\u6001\u4e0b\u5e73\u5747\u964d\u4f4e14.1\u5206\uff0c\u9ad8\u5242\u91cf\u7ec4\u83b7\u76ca\u66f4\u4e3a\u663e\u8457<\/strong>The<\/p>\n<p>\u5c3d\u7ba1\u6539\u5584\u5e45\u5ea6\u8f83Tabar\u8bd5\u9a8c18\u4e2a\u6708\u65f6\u768423\u5206\u964d\u5e45\u7565\u663e\u6e29\u548c\uff0c\u4f46\u4ecd\u5c5e\u4e09\u9879\u7814\u7a76\u4e2d\u6700\u4e3a\u7a81\u51fa\u7684\u7597\u6548\u4e4b\u4e00\u3002\u00b9\u2078F-FP-CIT PET\u663e\u50cf\u663e\u793a\u540e\u58f3\u6838\u591a\u5df4\u80fa\u8f6c\u8fd0\u4f53\u6444\u53d6\u663e\u8457\u589e\u52a0\uff0c\u4e3a\u79fb\u690d\u7269\u5b58\u6d3b\u548c\u518d\u795e\u7ecf\u652f\u914d\u63d0\u4f9b\u4e86\u5ba2\u89c2\u786e\u8ba4\uff0c\u8fdb\u4e00\u6b65\u5de9\u56fa\u4e86\u79fb\u690d\u7ec6\u80de\u6570\u91cf\u4e0e\u4e34\u5e8a\u6539\u5584\u7a0b\u5ea6\u4e4b\u95f4\u7684\u5242\u91cf\u4f9d\u8d56\u6027\u5173\u7cfb\u3002<\/p>\n<p>\u5c0f\u7ed3\uff1a\u4e09\u9879\u8bd5\u9a8c\u6c47\u96c6\u51fa\u4e00\u7cfb\u5217\u5171\u8bc6\uff1a\u5e72\u7ec6\u80de\u6765\u6e90\u7684\u591a\u5df4\u80fa\u80fd\u524d\u4f53\u7ec6\u80de\u5b89\u5168\uff0c\u80fd\u5728\u5bbf\u4e3b\u8111\u5185\u5b58\u6d3b\u3001\u4ea7\u751f\u591a\u5df4\u80fa\uff0c\u5e76\u4ee5\u5242\u91cf\u4f9d\u8d56\u6027\u65b9\u5f0f\u6539\u5584\u8fd0\u52a8\u75c7\u72b6\u3002\u5c3d\u7ba1\u7ec6\u80de\u6765\u6e90\u3001\u751f\u4ea7\u65b9\u6cd5\u4e0e\u5730\u57df\u5404\u4e0d\u76f8\u540c\uff0c\u8fd9\u4e9b\u7ed3\u679c\u5171\u540c\u6807\u5fd7\u7740\u9886\u57df\u5df2\u8de8\u8d8a\u80ce\u513f\u7ec4\u7ec7\u79fb\u690d\u7684\u5386\u53f2\u5c40\u9650\uff0c\u4e3a\u66f4\u5927\u89c4\u6a21\u5bf9\u7167\u7814\u7a76\u94fa\u5e73\u4e86\u9053\u8def\uff0c\u540e\u8005\u5c06\u8fdb\u4e00\u6b65\u660e\u786e\u8be5\u6cbb\u7597\u7b56\u7565\u7684\u957f\u671f\u6709\u6548\u6027\u4e0e\u6301\u4e45\u6027\u3002<\/p>\n<p>\u4e09\u9879\u8bd5\u9a8c\u6c47\u603b\u5bf9\u6bd4\u8868<\/p>\n<figure class=\"wp-block-table is-style-stripes\">\n<table class=\"has-fixed-layout\">\n<thead>\n<tr>\n<th>\u7ef4\u5ea6<\/th>\n<th>Sawamoto\uff08\u65e5\u672c\uff0ciPSC\uff09<\/th>\n<th>Tabar\uff08\u7f8e\/\u52a0\uff0chESC\uff09<\/th>\n<th>Chang\uff08\u97e9\u56fd\uff0chESC\uff09<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><strong>\u7ec6\u80de\u7c7b\u578b<\/strong><\/td>\n<td>iPSC\u6e90CORIN+\u7956\u7ec6\u80de<\/td>\n<td>hESC\u6e90\u524d\u4f53\uff08Bemdaneprocel\uff09<\/td>\n<td>hESC\u6e90A9-DPCs\uff08TED-A9\uff09<\/td>\n<\/tr>\n<tr>\n<td><strong>\u7ec6\u80de\u5242\u91cf\uff08\u9ad8\u5242\u91cf\u7ec4\uff09<\/strong><\/td>\n<td>5.3-5.5\u00d710\u2076\/\u4fa7<\/td>\n<td>2.7\u00d710\u2076\/\u4fa7<\/td>\n<td>6.3\u00d710\u2076\/\u4fa7\uff08\u603b\u91cf\uff09<\/td>\n<\/tr>\n<tr>\n<td><strong>\u514d\u75ab\u6291\u5236\u65f6\u957f<\/strong><\/td>\n<td>15\u4e2a\u6708<\/td>\n<td>12\u4e2a\u6708<\/td>\n<td>12\u4e2a\u6708<\/td>\n<\/tr>\n<tr>\n<td><strong>\u968f\u8bbf\u65f6\u95f4<\/strong><\/td>\n<td>24\u4e2a\u6708<\/td>\n<td>18\u4e2a\u6708<\/td>\n<td>12\u4e2a\u6708<\/td>\n<\/tr>\n<tr>\n<td><strong>MDS-UPDRS III\u6539\u5584<\/strong><\/td>\n<td>20.4%\u964d\u5e45\uff08\u7ea69.5\u5206\uff09<\/td>\n<td>23.0\u5206\u964d\u5e45<\/td>\n<td>14.1\u5206\u964d\u5e45<\/td>\n<\/tr>\n<tr>\n<td><strong>PET\u8bc1\u636e<\/strong><\/td>\n<td>\u9ad8\u5242\u91cf\u7ec4\u591a\u5df4\u80fa\u5408\u6210\u219163.5%<\/td>\n<td>\u79fb\u690d\u7269\u5b58\u6d3b<\/td>\n<td>\u591a\u5df4\u80fa\u8f6c\u8fd0\u4f53\u6444\u53d6\u2191<\/td>\n<\/tr>\n<tr>\n<td><strong>GIDs<\/strong><\/td>\n<td>not have<\/td>\n<td>not have<\/td>\n<td>not have<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/figure>\n<h2 id=\"ftoc-heading-6\" class=\"wp-block-heading ftwp-heading\"><span class=\"ez-toc-section\" id=\"%E5%9B%9B%E3%80%81%E5%89%8D%E7%9E%BB%E4%B8%8E%E6%8C%91%E6%88%98%EF%BC%9A%E9%A9%B6%E5%90%91%E6%9B%B4%E5%B9%BF%E4%B9%89%E7%9A%84%E4%BF%AE%E5%A4%8D\"><\/span>\u56db\u3001\u524d\u77bb\u4e0e\u6311\u6218\uff1a\u9a76\u5411\u66f4\u5e7f\u4e49\u7684\u4fee\u590d<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"41_%E6%A0%B8%E5%BF%83%E6%8A%80%E6%9C%AF%E7%93%B6%E9%A2%88%EF%BC%9A%E5%86%8D%E7%A5%9E%E7%BB%8F%E6%94%AF%E9%85%8D%E4%B8%8D%E5%9D%87\"><\/span>4.1 \u6838\u5fc3\u6280\u672f\u74f6\u9888\uff1a\u518d\u795e\u7ecf\u652f\u914d\u4e0d\u5747<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u5f53\u524dPET\u663e\u50cf\u5e38\u663e\u793a\u4ec5\u5f62\u6210<strong>\u5c40\u7076\u6027\u201c\u70ed\u70b9\u201d<\/strong>\uff0c\u8fdc\u672a\u5b9e\u73b0\u5168\u7eb9\u72b6\u4f53\u5747\u5300\u8986\u76d6\u3002\u540e\u7eed\u9700\u63a2\u7d22\uff1a<\/p>\n<ul class=\"wp-block-list\">\n<li>\u66f4\u9ad8\u7ec6\u80de\u5242\u91cf<\/li>\n<li>\u66f4\u7cbe\u7ec6\u7684\u591a\u8f68\u9053\u7acb\u4f53\u5b9a\u5411\u6ce8\u5c04<\/li>\n<li>\u660e\u786e\u6700\u4f73\u79fb\u690d\u90e8\u4f4d\u4e0e\u7ec6\u80de\u6570\u91cf<\/li>\n<\/ul>\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"42_%E7%96%97%E6%95%88%E9%9C%80%E8%B6%85%E8%B6%8A%E7%8E%B0%E6%9C%89%E7%96%97%E6%B3%95\"><\/span>4.2 \u7597\u6548\u9700\u8d85\u8d8a\u73b0\u6709\u7597\u6cd5<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u672a\u6765\u8bd5\u9a8c\u5fc5\u987b\u5728\u4e34\u5e8a\u6539\u5584\u7a0b\u5ea6\u4e0a\u5b9e\u73b0\u5bf9<strong>\u73b0\u6709\u836f\u7269\u53ca\u6df1\u90e8\u8111\u523a\u6fc0\uff08DBS\uff09<\/strong>\u00a0\u7684\u660e\u786e\u8d85\u8d8a\uff0c\u800c\u4e0d\u4ec5\u662f\u91cd\u590d\u65e9\u671f\u5f00\u653e\u6807\u7b7e\u7814\u7a76\u7684\u6548\u5e94\u5e45\u5ea6\u3002<\/p>\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"43_%E8%81%94%E5%90%88%E6%B2%BB%E7%96%97%E4%BD%93%E7%B3%BB%E7%9A%84%E6%9E%84%E5%BB%BA\"><\/span>4.3 \u8054\u5408\u6cbb\u7597\u4f53\u7cfb\u7684\u6784\u5efa<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\u5355\u7eaf\u7684\u591a\u5df4\u80fa\u80fd\u7ec6\u80de\u66ff\u4ee3\u65e0\u6cd5\u963b\u6b62\u75be\u75c5\u672c\u8eab\u7684\u6301\u7eed\u8fdb\u5c55\u3002\u9700\u8981\uff1a<\/p>\n<ul class=\"wp-block-list\">\n<li><strong>\u795e\u7ecf\u4fdd\u62a4\u5242<\/strong>respond in singing<strong>\u6297\u03b1-\u7a81\u89e6\u6838\u86cb\u767d\u7597\u6cd5<\/strong>\u534f\u540c\u4fdd\u62a4\u65b0\u751f\u795e\u7ecf\u5143<\/li>\n<li><strong>\u4e13\u95e8\u7684\u7269\u7406\u5eb7\u590d<\/strong>\u4fc3\u8fdb\u65b0\u795e\u7ecf\u56de\u8def\u7684\u529f\u80fd\u6027\u6574\u5408<\/li>\n<\/ul>\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"44_%E6%8A%80%E6%9C%AF%E8%BF%AD%E4%BB%A3%E6%96%B9%E5%90%91\"><\/span>4.4 \u6280\u672f\u8fed\u4ee3\u65b9\u5411<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<figure class=\"wp-block-table is-style-stripes\">\n<table class=\"has-fixed-layout\">\n<thead>\n<tr>\n<th>\u65b9\u5411<\/th>\n<th>\u76ee\u6807<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>CRISPR\/Cas9\u7f16\u8f91<\/td>\n<td>\u5236\u9020\u201c\u4f4e\u514d\u75ab\u539f\u6027\u201d\u6216\u201c\u901a\u7528\u201d\u4f9b\u4f53\u7ec6\u80de\uff0c\u6446\u8131\u957f\u671f\u514d\u75ab\u6291\u5236<\/td>\n<\/tr>\n<tr>\n<td>\u4e0b\u4e00\u4ee3\u5206\u9009\u65b9\u6848<\/td>\n<td>\u63d0\u9ad8\u524d\u4f53\u7ec6\u80de\u5411\u529f\u80fd\u6027\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u7684\u6210\u719f\u6548\u7387<\/td>\n<\/tr>\n<tr>\n<td>\u7cbe\u7ec6\u60a3\u8005\u7b5b\u9009<\/td>\n<td>\u5c06\u5bbf\u4e3b\u56e0\u7d20\u548c\u8111\u5fae\u73af\u5883\u7eb3\u5165\u8003\u91cf\uff0c\u786e\u4fdd\u5b89\u5168\u6574\u5408<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/figure>\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"45_%E9%95%BF%E6%9C%9F%E5%AE%89%E5%85%A8%E6%80%A7\"><\/span>4.5 \u957f\u671f\u5b89\u5168\u6027<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><strong>\u6700\u5927\u7684\u5e95\u7ebf\u95ee\u9898<\/strong>\uff1a\u786e\u8bc1iPSC\u6765\u6e90\u524d\u4f53\u7ec6\u80de\u4e0e\u5206\u5316\u795e\u7ecf\u5143\u7684<strong>\u957f\u671f\u5b89\u5168\u6027<\/strong>\uff08\u81f4\u7624\u98ce\u9669\u3001\u5f02\u5e38\u6574\u5408\u7b49\uff09\uff0c\u8fd9\u9700\u8981\u957f\u671f\u968f\u8bbf\u548c\u5927\u89c4\u6a21\u9a8c\u8bc1\u3002<\/p>\n<h2 id=\"ftoc-heading-7\" class=\"wp-block-heading ftwp-heading\"><span class=\"ez-toc-section\" id=\"%E4%BA%94%E3%80%81%E5%B8%B8%E8%A7%81%E9%97%AE%E9%A2%98%E8%A7%A3%E7%AD%94%EF%BC%88FAQ%EF%BC%89\"><\/span>\u4e94\u3001\u5e38\u89c1\u95ee\u9898\u89e3\u7b54\uff08FAQ\uff09<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E9%97%AE1%EF%BC%9A%E5%B9%B2%E7%BB%86%E8%83%9E%E6%B2%BB%E7%96%97%E5%B8%95%E9%87%91%E6%A3%AE%E7%97%85%E7%9B%AE%E5%89%8D%E6%88%90%E7%86%9F%E5%90%97%EF%BC%9F%E6%88%91%E5%AE%B6%E4%BA%BA%E8%83%BD%E7%94%A8%E4%B8%8A%E5%90%97%EF%BC%9F\"><\/span>\u95ee1\uff1a\u5e72\u7ec6\u80de\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\u76ee\u524d\u6210\u719f\u5417\uff1f\u6211\/\u5bb6\u4eba\u80fd\u7528\u4e0a\u5417\uff1f<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><strong>\u7b54<\/strong>::<strong>\u5c1a\u672a\u6210\u719f<\/strong>\u30022025\u5e74\u53d1\u8868\u7684\u4e09\u9879\u4e34\u5e8a\u8bd5\u9a8c\u662f<strong>\u9996\u6b21\u4eba\u4f53I\/II\u671f\u7814\u7a76<\/strong>\uff0c\u8bc1\u5b9e\u4e86\u5b89\u5168\u6027\u548c\u521d\u6b65\u7597\u6548\uff0c\u4f46<strong>\u5c1a\u672a\u6210\u4e3a\u5e38\u89c4\u4e34\u5e8a\u6cbb\u7597<\/strong>\u3002\u76ee\u524d\u5168\u7403\u65e0\u4efb\u4f55\u5e72\u7ec6\u80de\u4ea7\u54c1\u6b63\u5f0f\u83b7\u6279\u7528\u4e8e\u5e15\u91d1\u68ee\u75c5\u3002\u60a3\u8005\u53ef\u901a\u8fc7\u53c2\u52a0\u6b63\u89c4\u4e34\u5e8a\u8bd5\u9a8c\uff08\u514d\u8d39\uff09\u83b7\u5f97\u6cbb\u7597\u3002\u4efb\u4f55\u58f0\u79f0\u201c\u6210\u719f\u5e94\u7528\u201d\u5e76\u6536\u8d39\u7684\u673a\u6784\u5747\u5c5e\u8fdd\u89c4\u3002<\/p>\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E9%97%AE2%EF%BC%9A%E8%BF%99%E4%B8%89%E9%A1%B9%E8%AF%95%E9%AA%8C%E7%9A%84%E7%BB%93%E6%9E%9C%E5%88%B0%E5%BA%95%E6%9C%89%E5%A4%9A%E5%A5%BD%EF%BC%9F%E8%83%BD%E6%B2%BB%E5%A5%BD%E5%90%97%EF%BC%9F\"><\/span>\u95ee2\uff1a\u8fd9\u4e09\u9879\u8bd5\u9a8c\u7684\u7ed3\u679c\u5230\u5e95\u6709\u591a\u597d\uff1f\u80fd\u6cbb\u597d\u5417\uff1f<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><strong>\u7b54<\/strong>\uff1a\u7ed3\u679c<strong>\u4ee4\u4eba\u9f13\u821e\u4f46\u6709\u5c40\u9650\u6027<\/strong>::<\/p>\n<ul class=\"wp-block-list\">\n<li><strong>safety<\/strong>\uff1a\u4e09\u9879\u8bd5\u9a8c\u5747\u672a\u62a5\u544a\u79fb\u690d\u7269\u8bf1\u5bfc\u7684\u8fd0\u52a8\u969c\u788d\uff08GIDs\uff09\u3001\u80bf\u7624\u6216\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\uff0c\u8fd9\u662f\u91cd\u5927\u8fdb\u6b65\u3002<\/li>\n<li><strong>\u7597\u6548<\/strong>\uff1a\u5728\u201c\u505c\u836f\u201d\u72b6\u6001\u4e0b\uff0c\u8fd0\u52a8\u75c7\u72b6\u8bc4\u5206\uff08MDS-UPDRS III\uff09\u5e73\u5747\u6539\u5584<strong>14-23\u5206<\/strong>\uff08\u6700\u4f73\u8fbe23\u5206\uff09\uff0c\u4e14\u5448\u5242\u91cf\u4f9d\u8d56\u6027\u3002<strong>\u4f46\u8fd9\u4e0d\u662f\u6cbb\u6108<\/strong>\u2014\u2014\u60a3\u8005\u4ecd\u9700\u7ee7\u7eed\u670d\u7528\u5e38\u89c4\u836f\u7269\uff0c\u4e14\u975e\u8fd0\u52a8\u75c7\u72b6\uff08\u5982\u8ba4\u77e5\u969c\u788d\u3001\u81ea\u4e3b\u795e\u7ecf\u529f\u80fd\u7d0a\u4e71\uff09\u6539\u5584\u6709\u9650\u3002<\/li>\n<li><strong>\u957f\u671f\u6548\u679c<\/strong>\uff1a\u968f\u8bbf\u4ec512-24\u4e2a\u6708\uff0c\u6301\u4e45\u6027\u5c1a\u5f85\u9a8c\u8bc1\u3002<\/li>\n<\/ul>\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E9%97%AE3%EF%BC%9AiPSC%E5%92%8ChESC%E6%9C%89%E4%BB%80%E4%B9%88%E5%8C%BA%E5%88%AB%EF%BC%9F%E5%93%AA%E4%B8%AA%E6%9B%B4%E5%A5%BD%EF%BC%9F\"><\/span>\u95ee3\uff1aiPSC\u548chESC\u6709\u4ec0\u4e48\u533a\u522b\uff1f\u54ea\u4e2a\u66f4\u597d\uff1f<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><strong>\u7b54<\/strong>::<\/p>\n<figure class=\"wp-block-table is-style-stripes\">\n<table class=\"has-fixed-layout\">\n<thead>\n<tr>\n<th>\u7ef4\u5ea6<\/th>\n<th>iPSC<\/th>\n<th>hESC<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><strong>\u6765\u6e90<\/strong><\/td>\n<td>\u91cd\u7f16\u7a0b\u6210\u4f53\u7ec6\u80de\uff08\u5982\u76ae\u80a4\u3001\u8840\u7ec6\u80de\uff09<\/td>\n<td>\u80da\u80ce\u56ca\u80da\u671f\u5185\u7ec6\u80de\u56e2<\/td>\n<\/tr>\n<tr>\n<td><strong>\u4f26\u7406\u4e89\u8bae<\/strong><\/td>\n<td>\u65e0\uff08\u4e0d\u7834\u574f\u80da\u80ce\uff09<\/td>\n<td>\u6709\uff08\u4f20\u7edf\u6765\u6e90\u5b58\u5728\u4e89\u8bae\uff0c\u4f46\u5df2\u5efa\u7acb\u7ec6\u80de\u7cfb\u53ef\u8c41\u514d\uff09<\/td>\n<\/tr>\n<tr>\n<td><strong>\u4e2a\u4f53\u5316<\/strong><\/td>\n<td>\u53ef\u81ea\u4f53\uff08\u4f46\u6210\u672c\u6781\u9ad8\uff09\uff0c\u4e5f\u53ef\u5f02\u4f53<\/td>\n<td>\u4ec5\u5f02\u4f53<\/td>\n<\/tr>\n<tr>\n<td><strong>\u81f4\u7624\u98ce\u9669<\/strong><\/td>\n<td>\u7406\u8bba\u66f4\u9ad8\uff08\u9700\u4e25\u683c\u8d28\u63a7\uff09<\/td>\n<td>\u8f83\u4f4e\uff08\u4f46\u4ecd\u9700\u5173\u6ce8\uff09<\/td>\n<\/tr>\n<tr>\n<td><strong>\u6807\u51c6\u5316<\/strong><\/td>\n<td>\u9700\u6bcf\u4e2a\u4f9b\u4f53\u91cd\u5efa<\/td>\n<td>\u53ef\u5efa\u7acb\u7a33\u5b9a\u7ec6\u80de\u7cfb<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/figure>\n<p>\u76ee\u524d\u5c1a\u65e0\u5934\u5bf9\u5934\u6bd4\u8f83\u3002\u4e09\u9879\u8bd5\u9a8c\u4e2diPSC\u548chESC\u5747\u663e\u793a\u4e86\u826f\u597d\u5b89\u5168\u6027\u548c\u7597\u6548\u3002<\/p>\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E9%97%AE4%EF%BC%9A%E6%B2%BB%E7%96%97%E8%BF%87%E7%A8%8B%E6%98%AF%E6%80%8E%E6%A0%B7%E7%9A%84%EF%BC%9F%E9%9C%80%E8%A6%81%E5%BC%80%E9%A2%85%E5%90%97%EF%BC%9F\"><\/span>\u95ee4\uff1a\u6cbb\u7597\u8fc7\u7a0b\u662f\u600e\u6837\u7684\uff1f\u9700\u8981\u5f00\u9885\u5417\uff1f<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><strong>\u7b54<\/strong>\uff1a\u9700\u8981<strong>\u7acb\u4f53\u5b9a\u5411\u795e\u7ecf\u5916\u79d1\u624b\u672f<\/strong>\uff0c\u4f46\u5c5e\u4e8e\u5fae\u521b\u64cd\u4f5c\uff1a<\/p>\n<ul class=\"wp-block-list\">\n<li>\u672f\u524d\u5f71\u50cf\u5b9a\u4f4d\u58f3\u6838\u9776\u70b9<\/li>\n<li>\u5c40\u90e8\u9ebb\u9189\u6216\u8f7b\u5ea6\u9547\u9759<\/li>\n<li>\u9885\u9aa8\u94bb\u4e00\u5c0f\u5b54\uff0c\u901a\u8fc7<strong>\u5fae\u578b\u5957\u7ba1<\/strong>\u5c06\u7ec6\u80de\u60ac\u6db2\u7f13\u6162\u6ce8\u5165\u58f3\u6838\uff08\u591a\u9488\u9053\u3001\u591a\u70b9\u6c89\u79ef\uff09<\/li>\n<li>\u624b\u672f\u65f6\u95f4\u7ea62-4\u5c0f\u65f6\uff0c\u4f4f\u96623-7\u5929<\/li>\n<\/ul>\n<p>\u76f8\u6bd4\u6df1\u90e8\u8111\u523a\u6fc0\uff08DBS\uff09\u9700\u690d\u5165\u6c38\u4e45\u7535\u6781\uff0c\u7ec6\u80de\u79fb\u690d<strong>\u4e0d\u7559\u7f6e\u5f02\u7269<\/strong>\uff0c\u521b\u4f24\u66f4\u5c0f\u3002<\/p>\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E9%97%AE5%EF%BC%9A%E6%B2%BB%E7%96%97%E5%90%8E%E8%BF%98%E9%9C%80%E8%A6%81%E5%90%83%E8%8D%AF%E5%90%97%EF%BC%9F%E5%85%8D%E7%96%AB%E6%8A%91%E5%88%B6%E5%89%82%E8%A6%81%E6%9C%8D%E5%A4%9A%E4%B9%85%EF%BC%9F\"><\/span>\u95ee5\uff1a\u6cbb\u7597\u540e\u8fd8\u9700\u8981\u5403\u836f\u5417\uff1f\u514d\u75ab\u6291\u5236\u5242\u8981\u670d\u591a\u4e45\uff1f<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><strong>\u7b54<\/strong>::<\/p>\n<ul class=\"wp-block-list\">\n<li><strong>\u6297\u5e15\u91d1\u68ee\u75c5\u836f\u7269<\/strong>\uff1a\u672f\u540e\u4ecd\u9700\u8981\u3002\u79fb\u690d\u7269\u4ea7\u751f\u7684\u591a\u5df4\u80fa\u662f\u5c40\u90e8\u7684\uff0c\u65e0\u6cd5\u66ff\u4ee3\u5168\u8eab\u6027\u836f\u7269\uff0c\u4f46\u90e8\u5206\u60a3\u8005\u53ef\u80fd\u9010\u6e10\u51cf\u5c11\u5242\u91cf\u3002<\/li>\n<li><strong>\u514d\u75ab\u6291\u5236\u5242<\/strong>\uff1a\u5f02\u4f53\u79fb\u690d\u9700\u8981\u3002\u76ee\u524d\u65b9\u6848\u4e3a<strong>\u672f\u540e\u4f7f\u7528\u4ed6\u514b\u83ab\u53f8\u7ea612-15\u4e2a\u6708<\/strong>\uff0c\u4e4b\u540e\u505c\u836f\u3002\u672a\u6765\u82e5\u91c7\u7528\u201c\u514d\u75ab\u9003\u9038\u201d\u901a\u7528\u7ec6\u80de\uff0c\u53ef\u80fd\u5b8c\u5168\u514d\u9664\u3002<\/li>\n<\/ul>\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E9%97%AE6%EF%BC%9A%E6%B2%BB%E7%96%97%E8%B4%B9%E7%94%A8%E5%A4%9A%E5%B0%91%EF%BC%9F%E5%8C%BB%E4%BF%9D%E8%83%BD%E6%8A%A5%E9%94%80%E5%90%97%EF%BC%9F\"><\/span>\u95ee6\uff1a\u6cbb\u7597\u8d39\u7528\u591a\u5c11\uff1f\u533b\u4fdd\u80fd\u62a5\u9500\u5417\uff1f<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><strong>\u7b54<\/strong>\uff1a\u76ee\u524d\u4ec5\u9650<strong>\u4e34\u5e8a\u8bd5\u9a8c\u9636\u6bb5\uff0c\u5b8c\u5168\u514d\u8d39<\/strong>\uff08\u5305\u62ec\u7ec6\u80de\u4ea7\u54c1\u3001\u624b\u672f\u3001\u76f8\u5173\u68c0\u67e5\uff09\u3002\u6b63\u5f0f\u4e0a\u5e02\u540e\uff0c\u4ef7\u683c\u9884\u8ba1\u6602\u8d35\uff08\u53ef\u80fd\u6570\u5341\u4e07\u7f8e\u5143\uff09\u3002\u77ed\u671f\u5185\u65e0\u6cd5\u8fdb\u5165\u533b\u4fdd\u3002\u5efa\u8bae\u5173\u6ce8\u6b63\u89c4\u4e34\u5e8a\u8bd5\u9a8c\u62db\u52df\u4fe1\u606f\u3002<\/p>\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E9%97%AE7%EF%BC%9A%E5%93%AA%E4%BA%9B%E5%B8%95%E9%87%91%E6%A3%AE%E7%97%85%E6%82%A3%E8%80%85%E9%80%82%E5%90%88%E5%8F%82%E5%8A%A0%E8%BF%99%E7%B1%BB%E4%B8%B4%E5%BA%8A%E8%AF%95%E9%AA%8C%EF%BC%9F\"><\/span>\u95ee7\uff1a\u54ea\u4e9b\u5e15\u91d1\u68ee\u75c5\u60a3\u8005\u9002\u5408\u53c2\u52a0\u8fd9\u7c7b\u4e34\u5e8a\u8bd5\u9a8c\uff1f<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><strong>\u7b54<\/strong>\uff1a\u6839\u636e\u5386\u53f2\u7ecf\u9a8c\u548c\u73b0\u6709\u8bd5\u9a8c\u5165\u6392\u6807\u51c6\uff0c\u901a\u5e38\u8981\u6c42\uff1a<\/p>\n<ul class=\"wp-block-list\">\n<li><strong>\u5e74\u9f84<\/strong>\uff1a\u4e00\u822c50-70\u5c81<\/li>\n<li><strong>\u75c5\u7a0b<\/strong>\uff1a\u901a\u5e38\u22655\u5e74\uff0c\u4e14\u5bf9\u5de6\u65cb\u591a\u5df4\u53cd\u5e94\u826f\u597d\uff08\u8bc1\u660e\u591a\u5df4\u80fa\u80fd\u7cfb\u7edf\u4ecd\u5b58\u5728\uff09<\/li>\n<li><strong>\u75be\u75c5\u9636\u6bb5<\/strong>\uff1aHoehn-Yahr\u5206\u671f2-3\u671f\uff08\u4e2d\u5ea6\uff0c\u975e\u5367\u5e8a\u56f0\u96be\u6216\u4e25\u91cd\u6b8b\u75be\uff09<\/li>\n<li><strong>\u65e0\u4e25\u91cd\u8ba4\u77e5\u969c\u788d<\/strong>\uff1aMMSE\u6216MoCA\u8bc4\u5206\u8fbe\u6807<\/li>\n<li><strong>\u65e0\u6d3b\u52a8\u6027\u80bf\u7624\u3001\u4e25\u91cd\u611f\u67d3\u3001\u514d\u75ab\u7f3a\u9677<\/strong><\/li>\n<\/ul>\n<p>\u65e9\u671f\u60a3\u8005\u548c\u665a\u671f\u60a3\u8005\u901a\u5e38\u4e0d\u662f\u6700\u4f73\u5019\u9009\u8005\u3002\u5177\u4f53\u9700\u54a8\u8be2\u7814\u7a76\u56e2\u961f\u3002<\/p>\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E9%97%AE8%EF%BC%9A%E9%A2%84%E8%AE%A1%E4%BB%80%E4%B9%88%E6%97%B6%E5%80%99%E8%83%BD%E5%9C%A8%E4%B8%AD%E5%9B%BD%E5%BC%80%E5%B1%95%E4%B8%B4%E5%BA%8A%E8%AF%95%E9%AA%8C%E6%88%96%E4%B8%8A%E5%B8%82%EF%BC%9F\"><\/span>\u95ee8\uff1a\u9884\u8ba1\u4ec0\u4e48\u65f6\u5019\u80fd\u5728\u4e2d\u56fd\u5f00\u5c55\u4e34\u5e8a\u8bd5\u9a8c\u6216\u4e0a\u5e02\uff1f<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><strong>\u7b54<\/strong>::<\/p>\n<ul class=\"wp-block-list\">\n<li><strong>\u56fd\u5185\u4e34\u5e8a\u8bd5\u9a8c<\/strong>\uff1a\u5df2\u6709\u591a\u4e2a\u5e72\u7ec6\u80de\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\u9879\u76ee\u5728\u56fd\u5bb6\u5907\u6848\uff08\u53ef\u67e5\u8be2\u4e2d\u56fd\u4e34\u5e8a\u8bd5\u9a8c\u6ce8\u518c\u4e2d\u5fc3\uff09\uff0c\u4f46\u591a\u4e3aMSCs\u6216\u5176\u5b83\u7c7b\u578b\u7ec6\u80de\uff0c<strong>\u5c1a\u672a\u6709iPSC\/hESC\u6e90\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u79fb\u690d\u7684I\/III\u671f\u8bd5\u9a8c\u516c\u5f00\u62db\u52df<\/strong>\u3002\u9884\u8ba1\u672a\u67652-3\u5e74\u53ef\u80fd\u51fa\u73b0\u3002<\/li>\n<li><strong>\u4e0a\u5e02<\/strong>\uff1a\u82e5III\u671f\u8bd5\u9a8c\u987a\u5229\uff0c<strong>\u81f3\u5c11\u8fd8\u97005-8\u5e74<\/strong>\uff08\u6b27\u7f8e\u53ef\u80fd\u66f4\u65e9\uff09\u3002\u8bf7\u7406\u6027\u770b\u5f85\uff0c\u4e0d\u8981\u8f7b\u4fe1\u5546\u4e1a\u673a\u6784\u5ba3\u4f20\u3002<\/li>\n<\/ul>\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E9%97%AE9%EF%BC%9A%E8%AF%95%E9%AA%8C%E4%B8%AD%E6%8F%90%E5%88%B0%E7%9A%84%E2%80%9C%E7%A7%BB%E6%A4%8D%E7%89%A9%E8%AF%B1%E5%AF%BC%E7%9A%84%E8%BF%90%E5%8A%A8%E9%9A%9C%E7%A2%8D%EF%BC%88GIDs%EF%BC%89%E2%80%9D%E6%98%AF%E4%BB%80%E4%B9%88%EF%BC%9F%E4%B8%BA%E4%BB%80%E4%B9%88%E8%BF%99%E6%AC%A1%E8%AF%95%E9%AA%8C%E6%B2%A1%E6%9C%89%EF%BC%9F\"><\/span>\u95ee9\uff1a\u8bd5\u9a8c\u4e2d\u63d0\u5230\u7684\u201c\u79fb\u690d\u7269\u8bf1\u5bfc\u7684\u8fd0\u52a8\u969c\u788d\uff08GIDs\uff09\u201d\u662f\u4ec0\u4e48\uff1f\u4e3a\u4ec0\u4e48\u8fd9\u6b21\u8bd5\u9a8c\u6ca1\u6709\uff1f<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><strong>\u7b54<\/strong>\uff1aGIDs\u662f\u8fc7\u53bb\u80ce\u513f\u7ec4\u7ec7\u79fb\u690d\u4e2d\u51fa\u73b0\u7684\u4e25\u91cd\u5e76\u53d1\u75c7\u2014\u2014\u79fb\u690d\u7269\u4e2d\u6df7\u6742\u7684<strong>\u8840\u6e05\u7d20\u80fd\u795e\u7ecf\u5143<\/strong>\u91ca\u653e\u8fc7\u591a\u8840\u6e05\u7d20\uff0c\u5bfc\u81f4\u4e0d\u81ea\u4e3b\u7684\u821e\u8e48\u6837\u6216\u808c\u5f20\u529b\u969c\u788d\u6027\u8fd0\u52a8\u3002\u73b0\u4ee3\u65b9\u6848\u901a\u8fc7<strong>\u9ad8\u7eaf\u5ea6\u5206\u9009\uff08\u5982CORIN\u9633\u6027\u9009\u62e9\uff09<\/strong>\u00a0\u5254\u9664\u8840\u6e05\u7d20\u80fd\u7ec6\u80de\uff0c\u4ece\u6839\u672c\u4e0a\u907f\u514d\u4e86GIDs\u3002\u4e09\u9879\u8bd5\u9a8c\u5747\u672a\u62a5\u544aGIDs\uff0c\u662f\u91cd\u5927\u5b89\u5168\u8fdb\u6b65\u3002<\/p>\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E9%97%AE10%EF%BC%9A%E5%9B%BD%E5%86%85%E6%82%A3%E8%80%85%E5%A6%82%E4%BD%95%E8%8E%B7%E5%8F%96%E6%9C%80%E6%96%B0%E4%BF%A1%E6%81%AF%EF%BC%9F%E6%9C%89%E6%8E%A8%E8%8D%90%E7%9A%84%E5%8C%BB%E9%99%A2%E6%88%96%E4%B8%93%E5%AE%B6%E5%90%97%EF%BC%9F\"><\/span>\u95ee10\uff1a\u56fd\u5185\u60a3\u8005\u5982\u4f55\u83b7\u53d6\u6700\u65b0\u4fe1\u606f\uff1f\u6709\u63a8\u8350\u7684\u533b\u9662\u6216\u4e13\u5bb6\u5417\uff1f<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><strong>\u7b54<\/strong>::<\/p>\n<ul class=\"wp-block-list\">\n<li><strong>\u5173\u6ce8\u5b98\u65b9\u5e73\u53f0<\/strong>\uff1a\u56fd\u5bb6\u536b\u5065\u59d4\u5e72\u7ec6\u80de\u4e34\u5e8a\u7814\u7a76\u5907\u6848\u7cfb\u7edf\u3001\u4e2d\u56fd\u4e34\u5e8a\u8bd5\u9a8c\u6ce8\u518c\u4e2d\u5fc3\uff08<a href=\"https:\/\/www.chictr.org.cn\/\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">www.chictr.org.cn<\/a>\uff09<\/li>\n<li><strong>\u641c\u7d22\u5173\u952e\u8bcd<\/strong>\uff1a\u201c\u5e15\u91d1\u68ee\u75c5 + \u5e72\u7ec6\u80de + \u4e34\u5e8a\u8bd5\u9a8c\u201d<\/li>\n<li><strong>\u5efa\u8bae\u54a8\u8be2\u7684\u9876\u5c16\u4e2d\u5fc3<\/strong>\uff1a\u5317\u4eac\u5ba3\u6b66\u533b\u9662\u3001\u4e0a\u6d77\u745e\u91d1\u533b\u9662\u3001\u4e2d\u5c71\u5927\u5b66\u9644\u5c5e\u7b2c\u4e00\u533b\u9662\u3001\u7a7a\u519b\u519b\u533b\u5927\u5b66\u897f\u4eac\u533b\u9662\u7b49\uff08\u5747\u6709\u5e15\u91d1\u68ee\u75c5\u7ec6\u80de\u6cbb\u7597\u7814\u7a76\u65b9\u5411\uff09<\/li>\n<li><strong>\u91cd\u8981\u63d0\u793a<\/strong>\uff1a\u5207\u52ff\u4f7f\u7528\u641c\u7d22\u5f15\u64ce\u4e2d\u201c\u5e72\u7ec6\u80de\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\u201d\u7684\u5546\u4e1a\u5e7f\u544a\uff0c\u8fd9\u4e9b\u591a\u4e3a\u975e\u6b63\u89c4\u673a\u6784\u3002<\/li>\n<\/ul>\n<h2 id=\"ftoc-heading-8\" class=\"wp-block-heading ftwp-heading\"><span class=\"ez-toc-section\" id=\"%E5%85%AD%E3%80%81%E7%BB%93%E8%AF%AD%EF%BC%9A%E4%BB%8E%E5%8F%AF%E8%83%BD%E8%BF%88%E5%90%91%E6%9B%B4%E4%BC%98\"><\/span>\u516d\u3001\u7ed3\u8bed\uff1a\u4ece\u53ef\u80fd\u8fc8\u5411\u66f4\u4f18<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>\u7ec6\u80de\u66ff\u4ee3\u7597\u6cd5\u5df2\u4ece\u6982\u5ff5\u9a8c\u8bc1\u8fc8\u5165\u4e34\u5e8a\u53ef\u884c\u6027\u9636\u6bb5\u3002\u4ee5\u4eac\u90fd\u5927\u5b66\u8bd5\u9a8c\u4e3a\u4ee3\u8868\u7684\u540c\u79cd\u5f02\u4f53iPSC\u6e90\u6027\u591a\u5df4\u80fa\u80fd\u524d\u4f53\u7ec6\u80de\u79fb\u690d\uff0c\u63d0\u4f9b\u4e86\u9996\u4e2a\u5f3a\u6709\u529b\u7684\u540c\u884c\u8bc4\u5ba1\u8bc1\u636e\uff0c\u8bc1\u5b9e\u8be5\u5e72\u9884\u624b\u6bb5<strong>\u5b89\u5168\u4e14\u53ef\u884c<\/strong>\u2014\u2014\u672a\u89c1\u81f4\u7624\u6027\uff0c\u672a\u73b0GIDs\uff0c\u5e76\u89c2\u5bdf\u5230\u5242\u91cf\u4f9d\u8d56\u6027\u8fd0\u52a8\u529f\u80fd\u6539\u5584\u548cPET\u5f71\u50cf\u4e0a\u7684\u79fb\u690d\u7269\u5b58\u6d3b\u8bc1\u636e\u3002\u4e0e\u6b64\u540c\u65f6\uff0c\u65e8\u5728\u901a\u8fc7\u81ea\u4f53iPSC\u6d88\u9664\u514d\u75ab\u6291\u5236\u7684ASPIRO\u8bd5\u9a8c\uff08NCT06344026\uff09\uff0c\u4ee5\u53ca\u63a2\u7d22\u5242\u91cf\u9012\u589e\u7684STEM-PD\u8bd5\u9a8c\uff08NCT05635409\uff09\uff0c\u6b63\u4ece\u4e0d\u540c\u7ef4\u5ea6\u540c\u6b65\u63a8\u52a8\u9886\u57df\u524d\u884c\u3002<\/p>\n<p>\u7136\u800c\uff0c\u5f53\u524d\u7ed3\u679c\u4ecd\u987b\u8c28\u614e\u89e3\u8bfb\uff1a\u4e34\u5e8a\u6539\u5584\u7a0b\u5ea6\u5c1a\u672a\u660e\u786e\u8d85\u8d8a\u73b0\u6709\u836f\u7269\u548cDBS\uff0c\u4e14\u957f\u671f\u5b89\u5168\u6027\u59cb\u7ec8\u662f\u60ac\u800c\u672a\u51b3\u7684\u9996\u8981\u95ee\u9898\u3002\u9886\u57df\u7684\u6838\u5fc3\u547d\u9898\u5df2\u4ece\u00a0<strong>\u201c\u662f\u5426\u53ef\u80fd\u201d\u63a8\u8fdb\u4e3a\u201c\u5982\u4f55\u505a\u5f97\u66f4\u597d\u5e76\u60e0\u53ca\u6240\u6709\u60a3\u8005\u201d<\/strong>The<\/p>\n<p>\u5c3d\u7ba1\u6311\u6218\u91cd\u91cd\uff0c\u8fd9\u4e9b\u8bd5\u9a8c\u5df2\u5c06\u66ff\u6362\u4e27\u5931\u795e\u7ecf\u5143\u8fd9\u4e00\u4fee\u590d\u6027\u6cbb\u7597\u7684\u68a6\u60f3\uff0c\u4ece\u6982\u5ff5\u8f6c\u5316\u4e3a\u4e00\u79cd\u5177\u4f53\u4e14\u521d\u89c1\u6210\u6548\u7684\u4e34\u5e8a\u7b56\u7565\uff0c\u9884\u793a\u7740\u4e00\u4e2a\u5145\u6ee1\u5e0c\u671b\u7684\u65b0\u9ece\u660e\u3002<\/p>\n<hr class=\"wp-block-separator has-alpha-channel-opacity\" \/>\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\"><p>\u53c2\u8003\u8d44\u6599<\/p>\n<p>[1] Elvira, R., Chooi, W.H., Wang, H. et al. A new dawn for Parkinson\u2019s disease: commentary on the emergence of stem cell-based therapies.\u00a0<em>Transl Neurodegener<\/em>\u00a015, 20 (2026).\u00a0<a href=\"https:\/\/doi.org\/10.1186\/s40035-026-00556-2\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">https:\/\/doi.org\/10.1186\/s40035-026-00556-2<\/a><\/p>\n<p>[2] Sawamoto, N., Doi, D., Nakanishi, E. et al. Phase I\/II trial of iPS-cell-derived dopaminergic cells for Parkinson\u2019s disease.\u00a0<em>Nature<\/em>\u00a0641, 971\u2013977 (2025).\u00a0<a href=\"https:\/\/doi.org\/10.1038\/s41586-025-08700-0\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">https:\/\/doi.org\/10.1038\/s41586-025-08700-0<\/a><\/p>\n<p>[3] Tabar, V., Sarva, H., Lozano, A.M. et al. Phase I trial of hES cell-derived dopaminergic neurons for Parkinson\u2019s disease.\u00a0<em>Nature<\/em>\u00a0641, 978\u2013983 (2025).\u00a0<a href=\"https:\/\/doi.org\/10.1038\/s41586-025-08845-y\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">https:\/\/doi.org\/10.1038\/s41586-025-08845-y<\/a><\/p>\n<p>[4] Chang et al.\u00a0<em>Cell<\/em>\u00a0(2025).\u00a0<a href=\"https:\/\/www.cell.com\/action\/showCitFormats?pii=S0092-8674(25)01041-4\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">https:\/\/www.cell.com\/action\/showCitFormats?pii=S0092-8674(25)01041-4<\/a><\/p>\n<p><strong>\u514d\u8d23\u8bf4\u660e<\/strong>\uff1a\u672c\u6587\u4ec5\u7528\u4e8e\u4f20\u64ad\u79d1\u666e\u77e5\u8bc6\uff0c\u5206\u4eab\u884c\u4e1a\u89c2\u70b9\uff0c\u4e0d\u6784\u6210\u4efb\u4f55\u4e34\u5e8a\u8bca\u65ad\u5efa\u8bae\u6216\u6cbb\u7597\u63a8\u8350\u3002\u672c\u6587\u5185\u5bb9\u4e0d\u80fd\u66ff\u4ee3\u533b\u751f\u6216\u836f\u5242\u5e08\u7684\u4e13\u4e1a\u5efa\u8bae\u3002\u6240\u6709\u6cbb\u7597\u51b3\u7b56\u8bf7\u54a8\u8be2\u6b63\u89c4\u533b\u7597\u673a\u6784\u4e13\u79d1\u533b\u751f\u3002\u676d\u5409\u5e72\u7ec6\u80de\u6240\u53d1\u5e03\u7684\u4fe1\u606f\u4ec5\u4f9b\u53c2\u8003\u3002\u5982\u6709\u7248\u6743\u7b49\u7591\u95ee\uff0c\u8bf7\u968f\u65f6\u8054\u7cfb\u3002<\/p><\/blockquote>","protected":false},"excerpt":{"rendered":"<p>\u63cf\u8ff0\uff1a2025\u5e74\u300a\u81ea\u7136\u300b\u7b49\u591a\u9876\u520a\u53d1\u8868\u4e09\u9879\u91cc\u7a0b\u7891\u4e34\u5e8a\u8bd5\u9a8c\uff1aiPSC\u53cahESC\u884d\u751f\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u79fb\u690d\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\uff0c [&hellip;]<\/p>","protected":false},"author":1,"featured_media":21916,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[76],"tags":[159,150,158],"_links":{"self":[{"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/posts\/21914"}],"collection":[{"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/comments?post=21914"}],"version-history":[{"count":2,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/posts\/21914\/revisions"}],"predecessor-version":[{"id":21917,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/posts\/21914\/revisions\/21917"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/media\/21916"}],"wp:attachment":[{"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/media?parent=21914"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/categories?post=21914"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hjtdsm.cn\/en\/wp-json\/wp\/v2\/tags?post=21914"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}